Curcumin is a promising nutraceutical for chemoprevention of head and neck squamous cell carcinoma (HNSCC)
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Enhanced Systemic Bioavailability of Curcumin Through Transmucosal Administration of a Novel Microgranular Formulation: Background/Aim: Curcumin is a promising nutraceutical for chemoprevention of head and neck squamous cell carcinoma (HNSCC). Capsular formulations of curcumin demonstrate low systemic bioavailability. We aimed to determine if curcumin levels were higher in healthy volunteers and cancer patients with microgranular curcumin that allows for transmucosal absorption and identify a consistent biomarker. Patients and Methods: Eight healthy volunteers and 15 HNSCC patients ...περισσότερα »
Predicting Incidence and Severity of Microtubule-targeting Agent-induced Peripheral Neuropathy
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Establishment of a Novel In Vitro Model for Predicting Incidence and Severity of Microtubule-targeting Agent-induced Peripheral Neuropathy: Peripheral neuropathy (PN) is a major dose-limiting side-effect of microtubule-targeting agents (MTAs), considered to be induced by inhibition of axonal microtubules. Therefore, it was thought that a useful method for predicting the frequencies of severe sensory-PN (FPN) would be to evaluate the neurite-disrupting effects of MTAs. Using neurite outgrowth from neuron-like cell lines, we comprehensively evaluated the neurite-disrupting effects of ... περισσότερα »
Ferredoxin Reductase Is Useful for Predicting the Effect of Chemoradiation Therapy on Esophageal Squamous Cell Carcinoma
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Ferredoxin Reductase Is Useful for Predicting the Effect of Chemoradiation Therapy on Esophageal Squamous Cell Carcinoma: Background: Ferredoxin reductase (Fdxr) is the mitochondrial cytochrome P-450 NADPH reductase. Fdxr overexpression increases the sensitivity of tumor cells to apoptosis in response to chemotherapy through reactive oxygen species (ROS) production. The aim of the present study was to examine the Fdxr expression in esophageal squamous cell carcinoma (ESCC) and determine if the expression is useful for predicting response to chemoradiation therapy (CRT). Materials an... περισσότερα »
Copper transporter 1 (CTR1) represents an important determinant of cisplatin resistance
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Molecular Docking Analysis of Steroid-based Copper Transporter 1 Inhibitors: Copper transporter 1 (CTR1) represents an important determinant of cisplatin resistance. A series of 35 semi-substituted steroids were recently investigated on cisplatin-resistant CTR1-expressing A2780cis ovarian carcinoma cells as well as their parental sensitive counterparts regarding their cytotoxic and resistance-reversing features. In the present investigation, three compounds (*4*, *5*, *25*) were selected for molecular docking analysis on the homology-modelled human CTR1 transmembrane domain. Steroid...περισσότερα »
Vascular Innervation in Benign Neurofibromas of Patients with Neurofibromatosis Type 1
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Vascular Innervation in Benign Neurofibromas of Patients with Neurofibromatosis Type 1: Neurofibroma constitutes a heterogeneous group of solid tumours occurring sporadically or in association with syndromes. The aspect of these peripheral nerve sheath tumours may vary considerably, with disseminated tumours covering various parts of the body or nodular/diffuse plexiform neurofibroma that can grow to an impressive size. Although neurofibromas have vascular density comparable to that of normal tissue, they have tendency to bleed upon surgery which is poorly understood. Herein we inv...περισσότερα »
Cytological and Immunocytological Monitoring of Oropharyngeal Dysplasia and Squamous Cell Carcinomas
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Cytological and Immunocytological Monitoring of Oropharyngeal Dysplasia and Squamous Cell Carcinomas: Background/Aim: Due to the high recurrence rates of squamous cell carcinoma of the head and neck (SCCHN) and de-novo local secondary carcinomas, a close monitoring of patients is mandatory. In doubtful cases, a clearance by histological biopsy is necessary. This, however, bears potential complications. We analyzed the application of combined cytology and immunocytology in cytological brush smears for diagnosing pre-malignant and malignant lesions of the oral/oropharyngeal cavity. Ma... περισσότερα »
Meningothelial Meningiomas: ADC Fractions,Cell Count,Ki-67,Total Nucleic Areas and Average Nucleic Areas
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Correlation Between Different ADC Fractions, Cell Count, Ki-67, Total Nucleic Areas and Average Nucleic Areas in Meningothelial Meningiomas: Background: Meningioma is the most common intracranial tumor. The aim of the present study was to correlate apparent diffusion coefficient (ADC) values with cellularity, Ki-67 and nucleic area in meningioma cases. Patients and Methods: Twenty-four meningothelial meningiomas were included in the study. Diffusion-weighted imaging was performed using a multi-slice single-shot echo-planar imaging sequence. In all lesions minimal ADC values (ADCmin)... περισσότερα »
Ipsilateral Sphenoid Wing Dysplasia, Orbital Plexiform Neurofibroma and Fronto-Parietal Dermal Cylindroma in a Patient with Segmental Neurofibromatosis
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Ipsilateral Sphenoid Wing Dysplasia, Orbital Plexiform Neurofibroma and Fronto-Parietal Dermal Cylindroma in a Patient with Segmental Neurofibromatosis: Neurofibromatosis type 1 (NF1) is an autosomal-dominant inherited disease affecting various parts of the body. Penetrance is almost complete but the phenotype varies considerably. Recently, mosaicism in NF1 has come into the focus of scientific interest. This report refers to a patient with orbitotemporal-confined neurofibromatosis who developed a rare skin tumor in the region. from #Med Blogs by Alexandros G.Sfakianakis via Alex...περισσότερα »
Radiosurgery Using Tomotherapy for Patients with Brain Oligo-metastasis
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Radiosurgery Using Tomotherapy for Patients with Brain Oligo-metastasis: A Retrospective Analysis on Feasibility and Tolerance: Aim: Aim of the study was to evaluate feasibility and toxicities of exclusive radiosurgery using tomotherapy in patients with brain oligo-metastases. Patients and Methods: Between 2008 and 2013 68 patients underwent stereotactic radiosurgery (SRS). Mean patient age was 63 years. Brain was the only site involved in 32 patients, while 36 had extracranial disease. Pre-SRS MRI 56 patients had sovratentorial lesions, 10 subtentorial and 2 patients had both. Fift...περισσότερα »
Concurrent Chemoradiotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) in Patients with Nasopharyngeal Carcinoma
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Concurrent Chemoradiotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) in Patients with Nasopharyngeal Carcinoma: Background/Aim: Several randomized trials have shown that concurrent chemoradiotherapy (CCRT) either with or without adjuvant chemotherapy is more effective than radiotherapy-alone for treating nasopharyngeal carcinoma (NPC). The present study retrospectively evaluated the efficacy and toxicity of CCRT with docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy in patients with NPC. Patients and Methods: The study regimen consisted of two cycles of TPF chem... περισσότερα »
Comparison of Failure Patterns Between Conventional and Intensity-modulated Radiotherapy for Stage III and IV Head and Neck Squamous Cell Carcinoma
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Comparison of Failure Patterns Between Conventional and Intensity-modulated Radiotherapy for Stage III and IV Head and Neck Squamous Cell Carcinoma: Background: We compared the patterns of failure between 3-dimensional radiotherapy (3D-RT) and intensity-modulated radiotherapy (IMRT) for head and neck squamous cell carcinoma (HNSCC). Patients and Methods: We reviewed the medical records of 49 patients with stage III-IV HNSCC treated with concurrent chemoradiotherapy. The treatment outcome, patterns of failure, and toxicities were compared between 3D-RT and IMRT. Results: There were 13... περισσότερα »
Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases from Breast Cancer: Aim: To generate a tool that estimates the probability of developing new cerebral metastases after stereotactic radiosurgery (SRS) in breast cancer patients. Patients and Methods: SRS dose plus seven characteristics (age, performance score, number of cerebral metastases, maximum diameter of all metastases, location of metastases, extra-cerebral spread and time from breast cancer diagnosis until SRS) were analyzed regarding their ability to predict the probabilit... περισσότερα »
Fluorouracil-induced Hyperammonemia
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Fluorouracil-induced Hyperammonemia in a Patient with Colorectal Cancer: Fluorouracil (5-FU; Adrucil®) is a pyrimidine analog antineoplastic chemotherapy agent which works by interfering with DNA and RNA synthesis. It has an uncommon toxicity called hyperammonemic encephalopathy. This neurotoxicity is associated with a high-dose administration of 5-FU (2,600 mg/m2/week), with an incidence rate of 5.7%, and is not normally seen with the current dose of 1,200 mg/m2 infused over 46 h. The mechanism behind this neurotoxicity is not known but is possibly due to accumulation of fluorocitr...περισσότερα »
Assessing Response to New Treatments and Prognosis in Melanoma Patients, by the Biomarker S-100{beta}
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Assessing Response to New Treatments and Prognosis in Melanoma Patients, by the Biomarker S-100{beta}: Background/Aim: Malignant melanoma incidence is increasing over the last years, while mortality is strongly decreasing due to improved early detection, close monitoring of patients including disease biomarkers as well as introduction of new therapies. The aim of the present study was to evaluate biomarkers, mainly S-100β in melanoma patients, regarding its ability to assess treatment response, especially to new immunotherapies (anti-BRAF, ipilimumab, anti-PD-1) and evaluation of pr... περισσότερα »
Individuals negative for Helicbacter pylori antibody and with a normal pepsinogen test (group A)
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Predictors of Gastric Neoplasia in Cases Negative for Helicobacter pylori Antibody and with Normal Pepsinogen: Background/Aim: Individuals negative for Helicbacter pylori antibody and with a normal pepsinogen test (group A) are regarded as being at low risk in serum gastric cancer screening known as the ABC method, and endoscopy is not recommended; however, this group may include 2-10% of gastric cancer cases. Patients and Methods: A total of 345 individuals who underwent upper gastrointestinal endoscopy and were classified by ABC as group A (H. pylori antibody titer <10 U/ml, and p... περισσότερα »
Molecular Pathogenesis of Human Papillomavirus Type 16 in Tonsillar Squamous Cell Carcinoma
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Molecular Pathogenesis of Human Papillomavirus Type 16 in Tonsillar Squamous Cell Carcinoma: Aim: The present study aimed to explore the etiological role of human papillomavirus (HPV) in tonsillar squamous cell carcinoma (TSCC). Materials and Methods: HPV status, including viral load and E6 variants, and the expression of P53, p16INK4A, and FANCD2, in tissues of TSCC (n=24) and tonsillitis (n=31) were investigated. Results: The frequency of high-risk HPV (HPV-16) in TSCCs (42%) was higher than that of tonsillitis (16%). HPV-16 genome was partially or fully integrated in all HPV-16-p...περισσότερα »
Synergistic Cytotoxicity of Bendamustine and the BTK Inhibitor in a Mantle Cell Lymphoma Cell Line
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Synergistic Cytotoxicity of Bendamustine and the BTK Inhibitor in a Mantle Cell Lymphoma Cell Line: Background: Bendamustine is effective in B-cell malignancies, including mantle cell lymphoma (MCL), alone and in combination with other agents. This study investigated the combination effect of bendamustine and the Bruton tyrosine kinase (BTK) inhibitor PCI-32765 on MCL cell death and the underlying mechanisms. Materials and Methods: Cytotoxicity was examined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MIT) assay. Apoptosis was assessed by annexin V/propidium ...περισσότερα »
Suppression of AKT Potentiates Synergistic Cytotoxicity of Apigenin with TRAIL in Anaplastic Thyroid Carcinoma Cells
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Suppression of AKT Potentiates Synergistic Cytotoxicity of Apigenin with TRAIL in Anaplastic Thyroid Carcinoma Cells: Background: We studied the effect of apigenin in combination with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) on cell survival and the influence of AKT inhibition on the combined effect of apigenin with TRAIL in anaplastic thyroid carcinoma (ATC) cells. Materials and Methods: The human 8505C and CAL62 ATC cell lines were used. Results: Apigenin in combination with TRAIL, compared to apigenin alone, reduced cell viability and Bcl2 protein lev... περισσότερα »
Biomarker Analysis in a Phase II Study of Sunitinib in Patients with Advanced Melanoma
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Biomarker Analysis in a Phase II Study of Sunitinib in Patients with Advanced Melanoma: Aim: To investigate the efficacy of sunitinib in patients with advanced melanoma and to correlate angiogenic biomarkers with response and survival. Patients and Methods: We performed a phase II study in patients with advanced pre-treated melanoma. The primary endpoint was tumor response. Blood samples for biomarker analysis including vascular endothelial growth factor (VEGF), and its receptors VEGFR1 and -2, placental growth factor (PlGF) and circulating endothelial cells (CEC) were collected at ...περισσότερα »
Biochemical Effects of Levothyroxine Withdrawal in Patients with Differentiated Thyroid Cancer
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 2 δευτερόλεπτα
Biochemical Effects of Levothyroxine Withdrawal in Patients with Differentiated Thyroid Cancer: Background: Patients with differentiated thyroid carcinoma (DTC) are submitted to withdrawal of levothyroxine (LT4) aftter thyroidectomy, in order to undergo radiodine (131I) treatment. Patients and Methods: A total of 345 patients with a history of DTC were enrolled in the study. Their biochemical profile and serum free triiodothyronine (FT3), free thyroxine (FT4) and thyrotropin (TSH) levels were measured during withdrawal of LT4 treatment, and several months after restarting LT4. Resul... περισσότερα »
Doxycycline release collagen membrane on surgically created and contaminated defects
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 3 δευτερόλεπτα
Efficacy of doxycycline release collagen membrane on surgically created and contaminated defects in rat tibiae: A histopathological and microbiological study via Oral Biology Publication date: March 2016 *Source:*Archives of Oral Biology, Volume 63 Author(s): Esma Kütan, Gonca Duygu-Çapar, Ceyda Özçakir-Tomruk, Ozkan Cem Dilek, Fatma Özen, Özge Erdoğan, Ipek Özdemir, May Kroachi, Aydin Gürel BackgroundThe effects of systemic antibiotics on controlling infective pathogens after guided bone regeneration(GBR) procedures especially in membrane exposures are limited. However, local administ... περισσότερα »
Chronic Migraine Treatment With Botulinum Toxin-A: an Investigation of Functional Magnetic Resonance Imaging Changes.
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 3 δευτερόλεπτα
Chronic Migraine Treatment With Botulinum Toxin-A: an Investigation of Functional Magnetic Resonance Imaging Changes.: *Condition*: Chronic Migraine *Intervention*: Drug: Botulinum Toxin-A *Sponsor*: University of Manitoba *Recruiting* - verified December 2015 ArmsAssigned InterventionsExperimental: Treatment with Botox and fMRI screening Following baseline screening, participants will receive two subsequent treatments with botulinum-A toxin, each separated by 12 weeks. Participants will receive standardized botulinum-A toxin dosing for chronic migraine prophylaxis, comp...περισσότερα »
EMS assessment and treatment of asthma
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 3 δευτερόλεπτα
EMS assessment and treatment of asthma: 5 things to know: By Bob Sullivan Asthma is a chronic disease that affects 24 million people in the United States and causes 5,000 to 6,000 deaths each year [1,2]. Prompt recognition and treatment of asthma, a leading cause of respiratory compromise, by EMS providers can quickly relieve symptoms and improve patient outcomes. Here are five things you should know about caring for patients with asthma: *1. Asthma causes more problems with ventilation than oxygenation* Asthma attacks are caused by an exaggerated immune response, which triggers...περισσότερα »
Homologous Lipoblastic Differentiation in Dedifferentiated Liposarcoma
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 3 δευτερόλεπτα
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DOG1 Expression in Soft Tissue Tumors
Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 3 δευτερόλεπτα
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Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults in Western countries; it affects primarily older persons, with a median age at diagnosis of 72 years. Chlorambucil has been a standard first-line therapy in CLL, especially for older patients or those with coexisting… from Medicine via xlomafota13 on Inoreader http://ift.tt/1LXnLNe via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OJl08T via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt... περισσότερα »
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
The landscape of treatment for relapsed chronic lymphocytic leukemia (CLL) has recently changed with the introduction of agents that inhibit intracellular B-cell receptor signaling. Ibrutinib monotherapy and idelalisib in combination with rituximab induce responses in the majority of patients in… from Medicine via xlomafota13 on Inoreader http://ift.tt/1QpCKpM via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OJl20r via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://i... περισσότερα »
Letter: cytomegalovirus colitis in a patient treated with ipilimumab for metastatic melanoma
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
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Letter: management of post-operative Crohn's disease - thiopurines vs adalimumab– authors' reply
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Editors' declarations of interest
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
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Letter: cytomegalovirus colitis in a patient treated with ipilimumab for metastatic melanoma – authors' reply
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
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Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults in Western countries; it affects primarily older persons, with a median age at diagnosis of 72 years. Chlorambucil has been a standard first-line therapy in CLL, especially for older patients or those with coexisting… from #Medicine via ola Kala on Inoreader http://ift.tt/1LXnLNe via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QpUCkg via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1... περισσότερα »
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
The landscape of treatment for relapsed chronic lymphocytic leukemia (CLL) has recently changed with the introduction of agents that inhibit intracellular B-cell receptor signaling. Ibrutinib monotherapy and idelalisib in combination with rituximab induce responses in the majority of patients in… from #Medicine via ola Kala on Inoreader http://ift.tt/1QpCKpM via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OcIgHw via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift... περισσότερα »
Letter: wide variation in faecal calprotectin values according to the assay
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
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Letter: coffee consumption and gallstone disease – a cautionary note on the assignment of exposure values in dose–response meta-analyses. Authors' reply
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
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Editorial: what can be done when infliximab stops working in ulcerative colitis? Authors' reply
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
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Letter: management of post-operative Crohn's disease - thiopurines vs adalimumab
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
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Editorial: what can be done when infliximab stops working in ulcerative colitis?
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
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Letter: prostaglandin E1 therapy with alprostadil and risk reduction of early hepatic cellular carcinoma after liver transplantation – authors' reply
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
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ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
Background: Glioblastoma (GBM) is the most common and malignant intracranial tumor in adults and currently incurable. To specifically target natural killer (NK) cell activity to GBM, we employed NK-92/5.28.z cells that are continuously expanding human NK cells expressing an ErbB2-specific chimeric antigen receptor (CAR). Methods: ErbB2 expression in 56 primary tumors, four primary cell cultures, and seven established cell lines was assessed by immunohistochemistry and flow cytometry. Cell killing activity of NK-92/5.28.z cells was analyzed in in vitro cytotoxicity assays. In viv... περισσότερα »
Changes in Receipt of Cancer Screening in Medicare Beneficiaries Following the Affordable Care Act
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
Background: The Affordable Care Act (ACA) removed copayments for screening mammography and colonoscopy in Medicare beneficiaries, but its clinical impact is unknown. Methods: Using a 5% random sample of Medicare claims from 2009 through 2012 in individuals age 70 years or older who were due for screening, we examined claims for screening mammography and screening or surveillance colonoscopy for two years prior to ACA (2009–2010) and two years post-ACA (2011–2012). Receipt of the procedures at the patient level was compared across years using generalized estimating equations. Sta... περισσότερα »
Prostaglandin E1 therapy with alprostadil and risk reduction in early hepatic cellular carcinoma after liver transplantation
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
from Pharmacology via ola Kala on Inoreader http://ift.tt/1LXA24s via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QpUC3Q via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OcIOxh via IFTTT
Letter: coffee consumption and gallstone disease – a cautionary note on the assignment of exposure values in dose–response meta-analyses
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
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Letter: factors determining liver fibrosis – more to come
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
from Pharmacology via ola Kala on Inoreader http://ift.tt/1XNPGeQ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QpUz87 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OcIMpc via IFTTT
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
The landscape of treatment for relapsed chronic lymphocytic leukemia (CLL) has recently changed with the introduction of agents that inhibit intracellular B-cell receptor signaling. Ibrutinib monotherapy and idelalisib in combination with rituximab induce responses in the majority of patients in… from #Medicine via ola Kala on Inoreader http://ift.tt/1QpCKpM via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TQyhMJ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift... περισσότερα »
Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults in Western countries; it affects primarily older persons, with a median age at diagnosis of 72 years. Chlorambucil has been a standard first-line therapy in CLL, especially for older patients or those with coexisting… from Medicine via xlomafota13 on Inoreader http://ift.tt/1LXnLNe via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OJl08T via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt... περισσότερα »
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
The landscape of treatment for relapsed chronic lymphocytic leukemia (CLL) has recently changed with the introduction of agents that inhibit intracellular B-cell receptor signaling. Ibrutinib monotherapy and idelalisib in combination with rituximab induce responses in the majority of patients in… from Medicine via xlomafota13 on Inoreader http://ift.tt/1QpCKpM via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OJl20r via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://i... περισσότερα »
Letter: cytomegalovirus colitis in a patient treated with ipilimumab for metastatic melanoma
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
from Pharmacology via ola Kala on Inoreader http://ift.tt/1XNPMTK via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QpUCki via IFTTT
Letter: management of post-operative Crohn's disease - thiopurines vs adalimumab– authors' reply
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
from Pharmacology via ola Kala on Inoreader http://ift.tt/1LXA1h1 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OcIePX via IFTTT
Editors' declarations of interest
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
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Letter: cytomegalovirus colitis in a patient treated with ipilimumab for metastatic melanoma – authors' reply
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
from Pharmacology via ola Kala on Inoreader http://ift.tt/1LXA2kZ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OcIgHA via IFTTT
Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults in Western countries; it affects primarily older persons, with a median age at diagnosis of 72 years. Chlorambucil has been a standard first-line therapy in CLL, especially for older patients or those with coexisting… from #Medicine via ola Kala on Inoreader http://ift.tt/1LXnLNe via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QpUCkg via IFTTT
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
The landscape of treatment for relapsed chronic lymphocytic leukemia (CLL) has recently changed with the introduction of agents that inhibit intracellular B-cell receptor signaling. Ibrutinib monotherapy and idelalisib in combination with rituximab induce responses in the majority of patients in… from #Medicine via ola Kala on Inoreader http://ift.tt/1QpCKpM via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OcIgHw via IFTTT
Letter: wide variation in faecal calprotectin values according to the assay
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
from Pharmacology via ola Kala on Inoreader http://ift.tt/1XNPMmS via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QpUzox via IFTTT
Letter: coffee consumption and gallstone disease – a cautionary note on the assignment of exposure values in dose–response meta-analyses. Authors' reply
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
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Editorial: what can be done when infliximab stops working in ulcerative colitis? Authors' reply
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
from Pharmacology via ola Kala on Inoreader http://ift.tt/1XNPJaC via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QpUCk6 via IFTTT
Letter: management of post-operative Crohn's disease - thiopurines vs adalimumab
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
from Pharmacology via ola Kala on Inoreader http://ift.tt/1LXA10r via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QpUCkc via IFTTT
Editorial: what can be done when infliximab stops working in ulcerative colitis?
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
from Pharmacology via ola Kala on Inoreader http://ift.tt/1XNPJr2 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OcIezx via IFTTT
Letter: prostaglandin E1 therapy with alprostadil and risk reduction of early hepatic cellular carcinoma after liver transplantation – authors' reply
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
from Pharmacology via ola Kala on Inoreader http://ift.tt/1LXA10h via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OcIezo via IFTTT
ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma
Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες
Background: Glioblastoma (GBM) is the most common and malignant intracranial tumor in adults and currently incurable. To specifically target natural killer (NK) cell activity to GBM, we employed NK-92/5.28.z cells that are continuously expanding human NK cells expressing an ErbB2-specific chimeric antigen receptor (CAR). Methods: ErbB2 expression in 56 primary tumors, four primary cell cultures, and seven established cell lines was assessed by immunohistochemistry and flow cytometry. Cell killing activity of NK-92/5.28.z cells was analyzed in in vitro cytotoxicity assays. In viv... περισσότερα »
