Reduksjon av hjertedød skyldes ikke statiner
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
I kampen mot hjerteinfarkt er statiner blitt en av de mest solgte medikamentgruppene fra norske apotek. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1s4wXh6 via IFTTT
Abseil to pay back cancer treatment – Oxfordshire Guardian
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Abseil to pay back cancer treatment Oxfordshire Guardian Last May, Iain’s world fell apart after a trip to the dentist led to him being diagnosed with cancer of the tonsil, throat, back of the tongue and two lymph nodes in the neck. Under the care of the Churchill Hospital, he underwent treatment which … from […]
Prof Leisha Emmens describes the challenges of designing combination immunotherapy clinical trials for breast cancer https://t.co/xPz3uwEOCN
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Prof Leisha Emmens describes the challenges of designing combination immunotherapy clinical trials for breast cancer https://t.co/xPz3uwEOCN from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/734701583678722048 via IFTTT
BRAF inhibitor treatment of primary BRAF-mutant ameloblastoma with pathologic assessment of response.
*BRAF inhibitor treatment of primary BRAF-mutant ameloblastoma with pathologic assessment of response.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Feb 23; Authors: Tan S, Pollack JR, Kaplan MJ, Colevas AD, West RB Abstract OBJECTIVE: Molecular characterization of ameloblastoma has indicated a high frequency of driver mutations in BRAF and SMO. Preclinical data suggest that Food and Drug Administration-approved BRAF-targeted therapies may be immediately relevant for patients with ameloblastoma positive for the BRAF V600E mutation. METHODS: A neoadjuvant treatment regime of da... περισσότερα »
Accuracy of virtual surgical planning in two-jaw orthognathic surgery: comparison of planned and actual results.
*Accuracy of virtual surgical planning in two-jaw orthognathic surgery: comparison of planned and actual results.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Mar 14; Authors: Zhang N, Liu S, Hu Z, Hu J, Zhu S, Li Y Abstract OBJECTIVE: This study aims to evaluate the accuracy of virtual surgical planning in two-jaw orthognathic surgery via quantitative comparison of preoperative planned and postoperative actual skull models. STUDY DESIGN: Thirty consecutive patients who required two-jaw orthognathic surgery were included. A composite skull model was reconstructed by using Dig...περισσότερα »
Synergistic retention strategy of RGD active targeting and radiofrequency-enhanced permeability for intensified RF & chemotherapy synergistic tumor treatment.
*Synergistic retention strategy of RGD active targeting and radiofrequency-enhanced permeability for intensified RF & chemotherapy synergistic tumor treatment.* Biomaterials. 2016 May 12;99:34-46 Authors: Zhang K, Li P, He Y, Bo X, Li X, Li D, Chen H, Xu H Abstract Despite gaining increasing attention, chelation of multiple active targeting ligands greatly increase the formation probability of protein corona, disabling active targeting. To overcome it, a synergistic retention strategy of RGD-mediated active targeting and radiofrequency (RF) electromagnetic field-enhanced permeabi... περισσότερα »
Preventive effects of electrical stimulation on inflammation-induced muscle mitochondrial dysfunction.
*Preventive effects of electrical stimulation on inflammation-induced muscle mitochondrial dysfunction.* Acta Histochem. 2016 May 18; Authors: Tanaka K, Tanaka M, Takegaki J, Fujino H Abstract Cachexia is a complex metabolic syndrome associated with underlying chronic diseases and is characterized by the overexpression of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α), which impair muscle oxidative metabolism. We hypothesized that electrical stimulation (ES) would prevent decrement in muscle oxidative metabolism by suppressing the phosphorylation of p38 MA...περισσότερα »
Scientific Achievements May Not Reach Everyone: Understanding Disparities in Acute Leukemia.
*Scientific Achievements May Not Reach Everyone: Understanding Disparities in Acute Leukemia.* Curr Hematol Malig Rep. 2016 May 21; Authors: Patel MI Abstract Over the past decade, scientific advancements have resulted in improved survival from acute leukemia. Continued advancements are expected given the attention to precision medicine and the resulting growth in development and adoption of risk-stratified, personalized therapies. While precision medicine has great potential to improve acute leukemia outcomes, there remain significant barriers to ensuring equitable access to the...περισσότερα »
Challenges of diagnosing and managing the adolescent with heavy menstrual bleeding.
*Challenges of diagnosing and managing the adolescent with heavy menstrual bleeding.* Thromb Res. 2016 May 3;143:91-100 Authors: Zia A, Rajpurkar M Abstract Unpredictable, prolonged or heavy menstrual bleeding (HMB) may be expected for many adolescents soon after menarche. A decade of clinical experience and research has now established firmly that bleeding disorders (BD) are common in adolescents with HMB. Despite these advances, many questions remain, and several aspects of the diagnosis and management of BDs in adolescents are not supported by rigorous clinical trials. In this... περισσότερα »
BRAF inhibitor treatment of primary BRAF-mutant ameloblastoma with pathologic assessment of response.
*BRAF inhibitor treatment of primary BRAF-mutant ameloblastoma with pathologic assessment of response.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Feb 23; Authors: Tan S, Pollack JR, Kaplan MJ, Colevas AD, West RB Abstract OBJECTIVE: Molecular characterization of ameloblastoma has indicated a high frequency of driver mutations in BRAF and SMO. Preclinical data suggest that Food and Drug Administration-approved BRAF-targeted therapies may be immediately relevant for patients with ameloblastoma positive for the BRAF V600E mutation. METHODS: A neoadjuvant treatment regime of da... περισσότερα »
Accuracy of virtual surgical planning in two-jaw orthognathic surgery: comparison of planned and actual results.
*Accuracy of virtual surgical planning in two-jaw orthognathic surgery: comparison of planned and actual results.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Mar 14; Authors: Zhang N, Liu S, Hu Z, Hu J, Zhu S, Li Y Abstract OBJECTIVE: This study aims to evaluate the accuracy of virtual surgical planning in two-jaw orthognathic surgery via quantitative comparison of preoperative planned and postoperative actual skull models. STUDY DESIGN: Thirty consecutive patients who required two-jaw orthognathic surgery were included. A composite skull model was reconstructed by using Dig...περισσότερα »
Synthesis of novel fused quinazolinone derivatives.
*Synthesis of novel fused quinazolinone derivatives.* Mol Divers. 2016 May 21; Authors: Mahdavi M, Lotfi V, Saeedi M, Kianmehr E, Shafiee A Abstract A four-step synthetic route was developed for the synthesis of novel fused quinazolinones, quinazolino[3,4-a]quinazolinones, and isoinodolo[2,1-a]quinazolino[1,2-c]quinazolineones. Reaction of isatoic anhydride and different amines gave various 2-aminobenzamides. Then, reaction of 2-aminobenzamides with 2-nitrobenzaldehyde followed by the reduction of nitro group afforded 2-(2-aminophenyl)-3-aryl-2,3-dihydroquinazolin-4(1H)-one deriv... περισσότερα »
Quinazolinones-Phenylquinoxaline hybrids with unsaturation/saturation linkers as novel anti-proliferative agents.
*Quinazolinones-Phenylquinoxaline hybrids with unsaturation/saturation linkers as novel anti-proliferative agents.* Bioorg Med Chem Lett. 2016 May 11; Authors: Palem JD, Alugubelli GR, Bantu R, Nagarapu L, Polepalli S, Jain SN, Bathini R, Manga V Abstract A new series of novel quinazolinones with allylphenyl quinoxaline hybrids 9a-n were efficiently synthesized in good yields by the reaction of 3-allyl-2-methylquinazolin-4(3H)-one (5a-n) with bromophenyl)quinoxaline (8) utilizing Pd catalyzed Heck-cross coupling and evaluated for anti-proliferative activity against four cancer ce... περισσότερα »
Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance.
*Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance.* Diabetologia. 2016 May 21; Authors: Schulz TJ, Graja A, Huang TL, Xue R, An D, Poehle-Kronawitter S, Lynes MD, Tolkachov A, O'Sullivan LE, Hirshman MF, Schupp M, Goodyear LJ, Mishina Y, Tseng YH Abstract AIMS/HYPOTHESIS: Adipose tissue dysfunction is a prime risk factor for the development of metabolic disease. Bone morphogenetic proteins (BMPs) have previously been implicated in adipocyte formation. Here, we investigate the role of BMP signalling in adipose tissue health a... περισσότερα »
Human pericoronary adipose tissue as storage and possible supply site for oxidized low-density lipoprotein and high-density lipoprotein in coronary artery.
*Human pericoronary adipose tissue as storage and possible supply site for oxidized low-density lipoprotein and high-density lipoprotein in coronary artery.* J Cardiol. 2016 May 18; Authors: Uchida Y, Uchida Y, Shimoyama E, Hiruta N, Kishimoto T, Watanabe S Abstract BACKGROUND: Thickening of the pericoronary adipose tissue (PCAT) is a proven risk factor for coronary artery disease, but it is poorly understood whether PCAT stores pro-atherogenic substances with oxidized low-density lipoprotein (oxLDL) and low-density lipoprotein (LDL), and an anti-atherogenic substance with high-d...περισσότερα »
The clinical significance of the MIF homolog d-dopachrome tautomerase (MIF-2) and its circulating receptor (sCD74) in burn.
*The clinical significance of the MIF homolog d-dopachrome tautomerase (MIF-2) and its circulating receptor (sCD74) in burn.* Burns. 2016 May 18; Authors: Kim BS, Stoppe C, Grieb G, Leng L, Sauler M, Assis D, Simons D, Boecker AH, Schulte W, Piecychna M, Hager S, Bernhagen J, Pallua N, Bucala R Abstract BACKGROUND: We reported earlier that the cytokine macrophage migration inhibitory factor (MIF) is a potential biomarker in burn injury. In the present study, we investigated the clinical significance of the newly discovered MIF family member d-dopachrome tautomerase (DDT or MIF-2) ... περισσότερα »
Influence of pollution control on lead inhalation bioaccessibility in PM2.5: A case study of 2014 Youth Olympic Games in Nanjing.
*Influence of pollution control on lead inhalation bioaccessibility in PM2.5: A case study of 2014 Youth Olympic Games in Nanjing.* Environ Int. 2016 May 19;94:69-75 Authors: Li SW, Li HB, Luo J, Li HM, Qian X, Liu MM, Bi J, Cui XY, Ma LQ Abstract Pollution controls were implemented to improve the air quality for the 2014 Youth Olympic Games (YOG) in Nanjing. To investigate the influence of pollution control on Pb inhalation bioaccessibility in PM2.5, samples were collected before, during, and after YOG. The objectives were to identify Pb sources in PM2.5 using stable isotope fing... περισσότερα »
An uncommon manifestation of paraneoplastic cerebellar degeneration in a patient with high grade urothelial, carcinoma with squamous differentiation: A case report and literature review.
*An uncommon manifestation of paraneoplastic cerebellar degeneration in a patient with high grade urothelial, carcinoma with squamous differentiation: A case report and literature review.* BMC Cancer. 2016;16(1):324 Authors: Zhu Y, Chen S, Chen S, Song J, Chen F, Guo H, Shang Z, Wang Y, Zhou C, Shi B Abstract BACKGROUND: Paraneoplastic neurological syndromes (PNS) are rare disorders associated with malignant tumours, which are triggered by autoimmune reactions. Paraneoplastic cerebellar degeneration (PCD) is the PNS type most commonly associated with ovarian and breast cancer. Tw... περισσότερα »
Drug-induced liver injury caused by iodine-131.
*Drug-induced liver injury caused by iodine-131.* Clin Mol Hepatol. 2016 May 20; Authors: Kim CW, Park JS, Oh SH, Park JH, Shim HI, Yoon JW, Park JS, Hong SB, Kim JM, Le TB, Lee JW Abstract Iodine-131 is a radioisotope that is routinely used for the treatment of differentiated thyroid cancer after total or near-total thyroidectomy. However, there is some evidence that iodine-131 can induce liver injury . Here we report a rare case of drug-induced liver injury (DILI) caused by iodine-131 in a patient with regional lymph node metastasis after total thyroidectomy. A 47-year-old woma... περισσότερα »
Hypopituitarism in the elderly: a narrative review on clinical management of hypothalamic-pituitary-gonadal, hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes dysfunction.
*Hypopituitarism in the elderly: a narrative review on clinical management of hypothalamic-pituitary-gonadal, hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes dysfunction.* J Endocrinol Invest. 2016 May 21; Authors: Curtò L, Trimarchi F Abstract Hypopituitarism is an uncommon and under-investigated endocrine disorder in old age since signs and symptoms are unspecific and, at least in part, can be attributed to the physiological effects of aging and related co-morbidities. Clinical presentation is often insidious being characterized by non-specific manifestat... περισσότερα »
Interleukin (IL)-24 transforms the tumor microenvironment and induces anticancer immunity in a murine model of colon cancer.
*Interleukin (IL)-24 transforms the tumor microenvironment and induces anticancer immunity in a murine model of colon cancer.* Mol Immunol. 2016 May 19;75:11-20 Authors: Ma YF, Ren Y, Wu CJ, Zhao XH, Xu H, Wu DZ, Xu J, Zhang XL, Ji Y Abstract Interleukin-24 (IL-24) is a novel tumor suppressor and can mediate the induction of Th1-type cytokines from peripheral blood mononuclear cells. The individual properties of IL-24 have been previously examined; however, its in vivo immunological consequences and antitumor properties have not been previously evaluated with respect to colon canc...περισσότερα »
High Femoral Anteversion Is Related to Femoral Trochlea Dysplasia.
*High Femoral Anteversion Is Related to Femoral Trochlea Dysplasia.* Arthroscopy. 2016 May 18; Authors: Liebensteiner MC, Ressler J, Seitlinger G, Djurdjevic T, El Attal R, Ferlic PW Abstract PURPOSE: To investigate the possible relation between femoral anteversion (AV) and trochlear morphology. METHODS: Among 560 available lower-limb computed tomography (CT) scans, those with previous fracture, arthroplasty, or osteotomy were excluded and 40 cases were randomly selected. The following 4 lines were determined from the CT scans: 1 through the center of the femoral head and neck; 1 ... περισσότερα »
Folate-conjugated gold nanoparticle as a new nanoplatform for targeted cancer therapy.
*Folate-conjugated gold nanoparticle as a new nanoplatform for targeted cancer therapy.* J Cancer Res Clin Oncol. 2016 May 21; Authors: Samadian H, Hosseini-Nami S, Kamrava SK, Ghaznavi H, Shakeri-Zadeh A Abstract Conventional cancer treatment methods suffer from many limitations such as non-specificity and low efficacy in discrimination between healthy and cancer cells. Recent developments in nanotechnology have introduced novel and smart therapeutic nanomaterials that basically take advantage of various targeting approaches. Targeted nanomaterials selectively bind to the cance...περισσότερα »
Effect of p16 Status on the Quality-of-Life Experience During Chemoradiation for Locally Advanced Oropharyngeal Cancer: A Substudy of Randomized Trial Trans-Tasman Radiation Oncology Group (TROG) 02.02 (HeadSTART).
*Effect of p16 Status on the Quality-of-Life Experience During Chemoradiation for Locally Advanced Oropharyngeal Cancer: A Substudy of Randomized Trial Trans-Tasman Radiation Oncology Group (TROG) 02.02 (HeadSTART).* Int J Radiat Oncol Biol Phys. 2016 Mar 23; Authors: Ringash J, Fisher R, Peters L, Trotti A, O'Sullivan B, Corry J, Kenny L, Van Den Bogaert W, Wratten C, Rischin D Abstract PURPOSE: Human papillomavirus-associated oropharyngeal cancer (OPC) has a favorable prognosis. Current research de-escalates treatment, aiming to improve quality of life (QOL). Understanding the ...περισσότερα »
High E6 Gene Expression Predicts for Distant Metastasis and Poor Survival in Patients With HPV-Positive Oropharyngeal Squamous Cell Carcinoma.
*High E6 Gene Expression Predicts for Distant Metastasis and Poor Survival in Patients With HPV-Positive Oropharyngeal Squamous Cell Carcinoma.* Int J Radiat Oncol Biol Phys. 2016 Mar 10; Authors: Khwaja SS, Baker C, Haynes W, Spencer CR, Gay H, Thorstad W, Adkins DR, Nussenbaum B, Chernock RD, Lewis JS, Wang X Abstract PURPOSE: Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) have a favorable prognosis. As a result, de-escalation clinical trials are under way. However, approximately 10% of patients will experience distant recurrence ... περισσότερα »
Radiation Therapy for Head and Neck Cancer and Angioneogenesis: Good for Cancer, Bad for Carotids?
*Radiation Therapy for Head and Neck Cancer and Angioneogenesis: Good for Cancer, Bad for Carotids?* JACC Cardiovasc Imaging. 2016 May 11; Authors: Arbustini E, Kodama T, Favalli V PMID: 27209104 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1U8Lam8
Plaque Neovascularization Is Increased in Human Carotid Atherosclerosis Related to Prior Neck Radiotherapy: A Contrast-Enhanced Ultrasound Study.
*Plaque Neovascularization Is Increased in Human Carotid Atherosclerosis Related to Prior Neck Radiotherapy: A Contrast-Enhanced Ultrasound Study.* JACC Cardiovasc Imaging. 2016 May 11; Authors: Shah BN, Gujral DM, Chahal NS, Harrington KJ, Nutting CM, Senior R Abstract OBJECTIVES: The aim of this study was to determine the effect of radiotherapy (RT) on intraplaque neovascularization (IPN) in human carotid arteries. BACKGROUND: Exposure of the carotid arteries to RT during treatment for head and neck cancer is associated with increased risk for stroke. However, the effect of RT o... περισσότερα »
TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens.
*TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens.* Allergol Int. 2016 May 18; Authors: Hiraishi Y, Nambu A, Shibui A, Nakanishi W, Yamaguchi S, Morita H, Iikura M, McKenzie AN, Matsumoto K, Sudo K, Yamasoba T, Nagase T, Nakae S Abstract BACKGROUND: T cell immunoglobulin domain and mucin domain-containing molecule 3 (TIM-3), which is preferentially expressed on Th1 cells rather than Th2 cells, is considered to be a negative regulator of Th1 cell function. This suggests that TIM-3 indirectly enhances Th2-type immune responses by sup...περισσότερα »
Physiologic and Acoustic Effects of Opera Performance.
*Physiologic and Acoustic Effects of Opera Performance.* J Voice. 2016 May 18; Authors: Kwak PE, Stasney CR, Hathway JR, Guffey D, Minard CG, Ongkasuwan J Abstract INTRODUCTION/HYPOTHESIS: Opera performance is physiological and emotional, and singing performers utilize their larynges in often strenuous ways. Historically, the training of a classical voice has been considered the paragon of healthy singing. However, the natural history of a performing larynx has not been studied systematically. There is paucity of scientific studies to guide practice patterns, particularly with reg... περισσότερα »
[Cranial trepanation in primitive cultures].
*[Cranial trepanation in primitive cultures].* Neurocirugia (Astur). 2016 May 18; Authors: González-Darder JM Abstract A review is presented on cranial trepanations performed by primitive cultures. The scientific interest in this topic began after the discovery in 1965 by Ephraim G. Squier of a pre-Columbian trepanated skull, and studied by Paul Broca in Paris. Pseudotrepanation and other types of cranial manipulation are reviewed. The techniques, technology, and instruments for every type of trepanation are well known. There are a surprisingly high percentage of cases showing si... περισσότερα »
Delir bei kritisch kranken Patienten
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 30 δευτερόλεπτα
Häufig unerkannt Trotz seiner Signifikanz wird das Delir in der Routineversorgung vom intensivmedizinischen Team in vielen Fällen nicht adäquat diagnostiziert. Die Therapie des Delirs ist bestimmt durch nichtpharmakologische Maßnahmen. Ziele sind die frühe Identifikation, Reorientierung und Mobilisierung des Patienten, darüber hinaus die Förderung der geistigen Aktivität und die Etablierung eines adäquaten Tag-Nacht-Rhythmus. from #Medicine-SfakianakisAlexandros via […]
Verschlussikterus aufgrund einer …
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 30 δευτερόλεπτα
Diagnose aufgelöst! Der 50-Jährige hatte sich mit rechtsseitigen Oberbauchschmerzen, Ikterus, Stuhlentfärbung, dunklem Urin und Fieber vorgestellt. Die Überweisung in die Gastroenterologie war nach frustraner endoskopischer Sondierung des Gallengangs erfolgt. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qEsC2T via IFTTT
Verschlussikterus bei einem 50-jährigen Patienten
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 30 δευτερόλεπτα
Wie lautet Ihre Diagnose? Der 50-Jährige hatte sich mit rechtsseitigen Oberbauchschmerzen, Ikterus, Stuhlentfärbung, dunklem Urin und Fieber vorgestellt. Die Überweisung in die Gastroenterologie erfolgte nach frustraner endoskopischer Sondierung des Gallengangs. Um ein Malignom handelt es sich nicht, aber um was dann? from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/25htKN2 via IFTTT
Atmosphere, Vol. 7, Pages 73: Composition and Sources of Particulate Matter Measured near Houston, TX: Anthropogenic-Biogenic Interactions
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 30 δευτερόλεπτα
Particulate matter was measured in Conroe, Texas (~60 km north of downtown Houston, Texas) during the September 2013 DISCOVER-AQ campaign to determine the sources of particulate matter in the region. The measurement site is influenced by high biogenic emission rates as well as transport of anthropogenic pollutants from the Houston metropolitan area and is therefore […]
Systematic Review of the Application of Lean and Six Sigma Quality Improvement Methodologies in Radiology.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Systematic Review of the Application of Lean and Six Sigma Quality Improvement Methodologies in Radiology. J Am Coll Radiol. 2016 May 18; Authors: Amaratunga T, Dobranowski J Abstract PURPOSE: Preventable yet clinically significant rates of medical error remain systemic, while health care spending is at a historic high. Industry-based quality improvement (QI) methodologies show potential […]
Cost Utility of Omalizumab Compared with Standard of Care for the Treatment of Chronic Spontaneous Urticaria.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Cost Utility of Omalizumab Compared with Standard of Care for the Treatment of Chronic Spontaneous Urticaria. Pharmacoeconomics. 2016 May 21; Authors: Graham J, McBride D, Stull D, Halliday A, Alexopoulos ST, Balp MM, Griffiths M, Agirrezabal I, Zuberbier T, Brennan A Abstract BACKGROUND: Chronic spontaneous urticaria (CSU) negatively impacts patient quality of life and productivity […]
Brazilian oral herbal medication for osteoarthritis: a systematic review protocol.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Brazilian oral herbal medication for osteoarthritis: a systematic review protocol. Syst Rev. 2016;5(1):86 Authors: Moura MD, Lopes LC, Biavatti MW, Busse JW, Wang L, Kennedy SA, Bhatnaga N, Bergamaschi CC Abstract BACKGROUND: Osteoarthritis affects 1 % of the world’s population and is the most common cause of musculoskeletal impairment in the elderly. Herbal medications are […]
The magnitude and mechanisms of the weekend effect in hospital admissions: A protocol for a mixed methods review incorporating a systematic review and framework synthesis.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
The magnitude and mechanisms of the weekend effect in hospital admissions: A protocol for a mixed methods review incorporating a systematic review and framework synthesis. Syst Rev. 2016;5(1):84 Authors: Chen YF, Boyal A, Sutton E, Armoiry X, Watson S, Bion J, Tarrant C, HiSLAC Collaborative Abstract BACKGROUND: Growing literature has demonstrated that patients admitted to […]
Allergy and Asthma Care in the Mobile Phone Era.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Allergy and Asthma Care in the Mobile Phone Era. Clin Rev Allergy Immunol. 2016 May 21; Authors: Huang X, Matricardi PM Abstract Strategies to improve patients’ adherence to treatment are essential to reduce the great health and economic burden of allergic rhinitis and asthma. Mobile phone applications (apps) for a better management of allergic diseases […]
Prescriber knowledge and attitudes regarding non-administration of prescribed pharmacologic venous thromboembolism prophylaxis.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Prescriber knowledge and attitudes regarding non-administration of prescribed pharmacologic venous thromboembolism prophylaxis. J Thromb Thrombolysis. 2016 May 21; Authors: Piechowski KL, Elder S, Efird LE, Haut ER, Streiff MB, Lau BD, Kraus PS, Rand CS, Popoola VO, Hobson DB, Farrow NE, Shaffer D, Shermock KM Abstract Pharmacologic venous thromboembolism (VTE) prophylaxis is important patient safety […]
Persistence, temporal and spatial profiles of ultraviolet absorbents and phenolic personal care products in riverine and estuarine sediment of the Pearl River catchment, China.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Persistence, temporal and spatial profiles of ultraviolet absorbents and phenolic personal care products in riverine and estuarine sediment of the Pearl River catchment, China. J Hazard Mater. 2016 May 9; Authors: Peng X, Xiong S, Ou W, Wang Z, Tan J, Jin J, Tang C, Liu J, Fan Y Abstract A variety of personal care […]
The relevancy of controlled nanocrystallization on rifampicin characteristics and cytotoxicity
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Salma M Mohyeldin, Mohammed M Mehanna, Nazik A Elgindy Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt Purpose: This article investigated the influence of novel rifampicin nanosuspension (RIF NS) for enhancing drug delivery properties. Methods: RIF NS was fabricated using the antisolvent precipitation technique. The impact of solvent type and flow rate, […]
In vitro and in vivo targeting imaging of pancreatic cancer using a Fe3O4@SiO2 nanoprobe modified with anti-mesothelin antibody
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Fang Liu,1,* Wenjun Le,2,* Tianxiao Mei,2 Tiegong Wang,1 Luguang Chen,1 Yi Lei,1 Shaobin Cui,2 Bingdi Chen,2 Zheng Cui,2,3 Chengwei Shao1 1Radiology Department of Changhai Hospital, Second Military Medical University, 2Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai, People’s Republic of China; 3Department of Pathology, Wake Forest […]
Fatigue behaviors of HP-Mg, Mg-Ca and Mg-Zn-Ca biodegradable metals in air and simulated body fluid
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Publication date: Available online 21 May 2016 Source:Acta Biomaterialia Author(s): Dong Bian, Weirui Zhou, Yang Liu, Nan Li, Yufeng Zheng, Zhili Sun The dynamic loading in human body, along with the corrosive body fluid, presents a great challenge for the practical use of biodegradable magnesium implants. In this study, a high purity magnesium (99.99 wt.%) […]
Bleak allergy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
: First case report via Allergology International Dear Editor, The prevalence of fish allergy in the general population is 0.1%–3%.1 Bleak (Alburnus alburnus) is a river fish belonging to the Cyprinidae family ( Fig. 1).2 Different fish-related panallergens have been described. 1, 3 and 4 We report the first case of allergy to bleak where […]
Enteral Access is not Required for Esophageal Cancer Patients Undergoing Neoadjuvant Therapy.
*Enteral Access is not Required for Esophageal Cancer Patients Undergoing Neoadjuvant Therapy.* Ann Thorac Surg. 2016 May 18; Authors: Huerter ME, Charles EJ, Downs EA, Hu Y, Lau CL, Isbell JM, McMurry TL, Kozower BD Abstract BACKGROUND: The nutritional status of esophageal cancer patients during neoadjuvant therapy remains a challenging problem. The objective of this study was to determine whether routine enteral feeding tube placement improved nutritional status and perioperative outcomes for patients undergoing neoadjuvant therapy for esophageal cancer. METHODS: The Society of... περισσότερα »
Nuclear inclusions mimicking poly(A)-binding protein nuclear 1 inclusions in a case of inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia with a novel mutation in the valosin-containing protein gene.
*Nuclear inclusions mimicking poly(A)-binding protein nuclear 1 inclusions in a case of inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia with a novel mutation in the valosin-containing protein gene.* Neuromuscul Disord. 2016 May 5; Authors: Matsubara S, Shimizu T, Komori T, Mori-Yoshimura M, Minami N, Hayashi YK Abstract A middle-aged Japanese man presented with slowly progressive asymmetric weakness of legs and arm but had neither ptosis nor dysphagia. He had a family history of similar condition suggestive of autosomal dominant inherita...περισσότερα »
Traumatic aortic aneurysm diagnosed by computed tomography angiography in a 22-year-old man presenting with progressive dyspnea and dysphagia.
*Traumatic aortic aneurysm diagnosed by computed tomography angiography in a 22-year-old man presenting with progressive dyspnea and dysphagia.* Int J Cardiovasc Imaging. 2016 May 21; Authors: Ma X, Ma YT, Liu AH, Wang YL Abstract Traumatic aortic aneurysm is a rare and potentially fatal complication that can occur secondary to acute chest trauma. However, early diagnosis of this complication is often neglected due to the presence of severe chest and abdominal trauma. We report a case of delayed traumatic aortic aneurysm that was diagnosed by computed tomography angiography on day... περισσότερα »
Biomarkers to distinguish functional constipation from irritable bowel syndrome with constipation
Abstract Treatments for functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C) differ, but symptom criteria do not reliably distinguish between them; some regard FC and IBS-C as parts of a single constipation spectrum. Our goal was to review studies comparing FC and IBS-C to identify possible biomarkers that separate them. A systematic review identified 15 studies that compared physiologic tests in FC *vs* IBS-C. Pain thresholds were lower in IBS-C than FC for 3/5 studies and not different in 2/5. Colonic motility was decreased more in FC than IBS-C for ... περισσότερα »
BRAF inhibitor treatment of primary BRAF-mutant ameloblastoma with pathologic assessment of response.
*BRAF inhibitor treatment of primary BRAF-mutant ameloblastoma with pathologic assessment of response.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Feb 23; Authors: Tan S, Pollack JR, Kaplan MJ, Colevas AD, West RB Abstract OBJECTIVE: Molecular characterization of ameloblastoma has indicated a high frequency of driver mutations in BRAF and SMO. Preclinical data suggest that Food and Drug Administration-approved BRAF-targeted therapies may be immediately relevant for patients with ameloblastoma positive for the BRAF V600E mutation. METHODS: A neoadjuvant treatment regime of da... περισσότερα »
Accuracy of virtual surgical planning in two-jaw orthognathic surgery: comparison of planned and actual results.
*Accuracy of virtual surgical planning in two-jaw orthognathic surgery: comparison of planned and actual results.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Mar 14; Authors: Zhang N, Liu S, Hu Z, Hu J, Zhu S, Li Y Abstract OBJECTIVE: This study aims to evaluate the accuracy of virtual surgical planning in two-jaw orthognathic surgery via quantitative comparison of preoperative planned and postoperative actual skull models. STUDY DESIGN: Thirty consecutive patients who required two-jaw orthognathic surgery were included. A composite skull model was reconstructed by using Dig...περισσότερα »
IJMS, Vol. 17, Pages 791: Circulating MicroRNAs as Biomarkers in Biliary Tract Cancers
[image: ag] Biliary tract cancers (BTCs) are a group of highly aggressive malignant tumors with a poor prognosis. The current diagnosis is based mainly on imaging and intraoperative exploration due to brush cytology havinga low sensitivity and the standard markers, such as carcinoembryonic antigen (CEA) and carbohydrate 19-9 (CA19-9), not having enough sensitivity nor specificity to be used in a differential diagnosis and early stage detection. Thus, better non-invasive methods that can distinguish between normal and pathological tissue are needed. MicroRNAs (miRNAs) are small, si... περισσότερα »
IJMS, Vol. 17, Pages 793: The Role of Proanthocyanidins Complex in Structure and Nutrition Interaction in Alfalfa Forage
Alfalfa (Medicago sativa L.) is one of the main forages grown in the world. Alfalfa is a winter hardy, drought tolerant, N-fixing legume with a good longevity, high yield, high nutrient levels, high digestibility, unique structural to non-structural components ratio, high dry matter intake, and high animal productivity per hectare. However, its main limitation is its excessively rapid initial rate of protein degradation in the rumen, which results in pasture bloat and inefficient use of protein with consequent excessive excretions of nitrogen into the environment. Proanthocyanidins... περισσότερα »
IJMS, Vol. 17, Pages 794: Gibberellic Acid: A Key Phytohormone for Spikelet Fertility in Rice Grain Production
[image: ag] The phytohormone gibberellic acid (GA) has essential signaling functions in multiple processes during plant development. In the "Green Revolution", breeders developed high-yield rice cultivars that exhibited both semi-dwarfism and altered GA responses, thus improving grain production. Most studies of GA have concentrated on germination and cell elongation, but GA also has a pivotal role in floral organ development, particularly in stamen/anther formation. In rice, GA signaling plays an important role in spikelet fertility; however, the molecular genetic and biochemical ... περισσότερα »
IJMS, Vol. 17, Pages 793: The Role of Proanthocyanidins Complex in Structure and Nutrition Interaction in Alfalfa Forage
Alfalfa (Medicago sativa L.) is one of the main forages grown in the world. Alfalfa is a winter hardy, drought tolerant, N-fixing legume with a good longevity, high yield, high nutrient levels, high digestibility, unique structural to non-structural components ratio, high dry matter intake, and high animal productivity per hectare. However, its main limitation is its excessively rapid initial rate of protein degradation in the rumen, which results in pasture bloat and inefficient use of protein with consequent excessive excretions of nitrogen into the environment. Proanthocyanidins... περισσότερα »
IJMS, Vol. 17, Pages 794: Gibberellic Acid: A Key Phytohormone for Spikelet Fertility in Rice Grain Production
[image: ag] The phytohormone gibberellic acid (GA) has essential signaling functions in multiple processes during plant development. In the "Green Revolution", breeders developed high-yield rice cultivars that exhibited both semi-dwarfism and altered GA responses, thus improving grain production. Most studies of GA have concentrated on germination and cell elongation, but GA also has a pivotal role in floral organ development, particularly in stamen/anther formation. In rice, GA signaling plays an important role in spikelet fertility; however, the molecular genetic and biochemical ... περισσότερα »
Symmetry, Vol. 8, Pages 37: Optional Frame Selection Algorithm for Adaptive Symmetric Service of Augmented Reality Big Data on Smart Devices
Following recent technological advances in diverse mobile devices, including smartphones, tablets and smartwatches, in-depth studies aimed at improving the quality of augmented reality (AR) are currently ongoing. Smartphones feature the essential elements of AR implementation, such as a camera, a processor and a display in a single device. As a result, additional hardware expansion for AR implementation has become unnecessary, popularizing AR technology at the user level. In the early stages, low-level AR technology was used mainly in limited fields, including simple road guides a...περισσότερα »
IJERPH, Vol. 13, Pages 520: Antifungal Effect of Henna against Candida albicans Adhered to Acrylic Resin as a Possible Method for Prevention of Denture Stomatitis
Denture stomatitis is a very common disease affecting the oral mucosa of denture wearers. The aim of this study was to measure the antifungal effect of henna against Candida albicans adhered to acrylic resin as a possible method for prevention of denture stomatitis. One-hundred-eighty acrylic plates were prepared of heat-cured acrylic denture resin. The specimens were divided into six groups of 30 samples each. The first group was only polymer and monomer following the conventional manufacturer instruction for processing complete dentures. The other five groups were processed by a... περισσότερα »
Atmosphere, Vol. 7, Pages 73: Composition and Sources of Particulate Matter Measured near Houston, TX: Anthropogenic-Biogenic Interactions
[image: ag] Particulate matter was measured in Conroe, Texas (~60 km north of downtown Houston, Texas) during the September 2013 DISCOVER-AQ campaign to determine the sources of particulate matter in the region. The measurement site is influenced by high biogenic emission rates as well as transport of anthropogenic pollutants from the Houston metropolitan area and is therefore an ideal location to study anthropogenic-biogenic interactions. Data from an Aerosol Chemical Speciation Monitor (ACSM) suggest that on average 64 percent of non-refractory PM1 was organic material, including... περισσότερα »
Water, Vol. 8, Pages 216: Opening the Black Box: Using a Hydrological Model to Link Stakeholder Engagement with Groundwater Management
Stakeholder participation is a foundation of good water governance. Good groundwater governance typically involves the co-production of knowledge about the groundwater system. Models provide a vehicle for producing this knowledge, as well as a "boundary object" around which scientists and stakeholders can convene the co-production process. Through co-production, stakeholders and scientific experts can engage in exchanges that create system knowledge not otherwise achievable. The process involves one-way transfer of information, active two-way conversations, and integration of mult... περισσότερα »
Enteral Access is not Required for Esophageal Cancer Patients Undergoing Neoadjuvant Therapy.
*Enteral Access is not Required for Esophageal Cancer Patients Undergoing Neoadjuvant Therapy.* Ann Thorac Surg. 2016 May 18; Authors: Huerter ME, Charles EJ, Downs EA, Hu Y, Lau CL, Isbell JM, McMurry TL, Kozower BD Abstract BACKGROUND: The nutritional status of esophageal cancer patients during neoadjuvant therapy remains a challenging problem. The objective of this study was to determine whether routine enteral feeding tube placement improved nutritional status and perioperative outcomes for patients undergoing neoadjuvant therapy for esophageal cancer. METHODS: The Society of... περισσότερα »
Nuclear inclusions mimicking poly(A)-binding protein nuclear 1 inclusions in a case of inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia with a novel mutation in the valosin-containing protein gene.
*Nuclear inclusions mimicking poly(A)-binding protein nuclear 1 inclusions in a case of inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia with a novel mutation in the valosin-containing protein gene.* Neuromuscul Disord. 2016 May 5; Authors: Matsubara S, Shimizu T, Komori T, Mori-Yoshimura M, Minami N, Hayashi YK Abstract A middle-aged Japanese man presented with slowly progressive asymmetric weakness of legs and arm but had neither ptosis nor dysphagia. He had a family history of similar condition suggestive of autosomal dominant inherita...περισσότερα »
Traumatic aortic aneurysm diagnosed by computed tomography angiography in a 22-year-old man presenting with progressive dyspnea and dysphagia.
*Traumatic aortic aneurysm diagnosed by computed tomography angiography in a 22-year-old man presenting with progressive dyspnea and dysphagia.* Int J Cardiovasc Imaging. 2016 May 21; Authors: Ma X, Ma YT, Liu AH, Wang YL Abstract Traumatic aortic aneurysm is a rare and potentially fatal complication that can occur secondary to acute chest trauma. However, early diagnosis of this complication is often neglected due to the presence of severe chest and abdominal trauma. We report a case of delayed traumatic aortic aneurysm that was diagnosed by computed tomography angiography on day... περισσότερα »
Hearing Aid Selection and Fitting Tips Gleaned from Recent Research
The first thing I would like to talk about is the Acceptable Noise Level (ANL) test that was developed at the University of Tennessee, based on the research of Anna Nabelek dating back to 1991. For those of you who are not familiar with this test, here is a quick review of how it works: The test usually is conducted bilaterally in the sound field, not under earphones. You first determine the patient's most comfortable listening level (MCL) for continuous discourse. The standard material is a travelogue about Arizona. It's a loudness task, not a speech recognition task, so the actua... περισσότερα »
Hearing Aid Directionality with Binaural Processing
The fact that two ears are better than one is well-established. The human auditory system integrates information from both ears providing benefits in terms of loudness, localization, sound quality, noise suppression, speech clarity and listening in noise. The ability to selectively attend to particular sounds, like a single voice among many talkers, is one of the most amazing and significant benefits of binaural hearing. [image: 1XLZ80h] from #Audiology via ola Kala on Inoreader http://ift.tt/1OIhsAd via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis... περισσότερα »
The Early Days of PEG and PEGylation (1970s-1990s)
Publication date: Available online 21 May 2016 *Source:*Acta Biomaterialia Author(s): Allan S. Hoffman The idea to conjugate PEG [poly(ethylene glycol)] to a protein, i.e., to "PEGylate" a protein, was first proposed by Prof. Frank Davis (Rutgers Univ.) in the late 1960s. He wanted to make the new recombinant proteins less immunogenic in our bodies, and thereby enhance their circulation and activity lifetimes. He thought that if he could conjugate a hydrophilic polymer to the "new" protein, it might not be recognized by the immune system as a foreign molecule. This article is a cont... περισσότερα »
Biomimetic contact lenses eluting olopatadine for allergic conjunctivitis
Publication date: Available online 21 May 2016 *Source:*Acta Biomaterialia Author(s): Clara González-Chomón, Maite Silva, Angel Concheiro, Carmen Alvarez-Lorenzo Combination of the ability of contact lenses (CLs) to act as a physical barrier against airborne antigen and to serve as a sustained depot of antihistaminic drugs may improve the efficiency of treatments of some ocular allergic diseases. The aim of this work was to develop CLs that exhibit affinity to olopatadine by mimicking the composition of the natural H1-receptor for which olopatadine behaves as a selective antagonist.... περισσότερα »
Development of a new family of monolithic calcium (pyro)phosphate glasses by soft chemistry
Publication date: Available online 21 May 2016 *Source:*Acta Biomaterialia Author(s): Jérémy Soulié, Pierre Gras, Olivier Marsan, Danielle Laurencin, Christian Rey, Christèle Combes The development of bioactive phosphate-based glasses is essential in biomaterials science, and especially for bone substitution applications. In this context, the preparation of amorphous calcium-phosphorus hydroxide/oxide monoliths at low temperature is a key challenge for being able to develop novel hybrid materials for these applications. We herein report for the first time the synthesis and physical ... περισσότερα »
IJMS, Vol. 17, Pages 771: Analysis of 2-(2-Phenylethyl)chromones by UPLC-ESI-QTOF-MS and Multivariate Statistical Methods in Wild and Cultivated Agarwood
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Agarwood is the fragrant resinous material mainly formed from species of Aquilaria. 2-(2-phenylethyl)chromones, especially the highly oxidized 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones, are the main representative compounds from agarwood. It is important to determine whether agarwood in trade is from cultivated trees or natural trees in the Convention on the International Trade in Endangered Species (CITES). We characterized the […]
IJMS, Vol. 17, Pages 795: Cold-Induced Browning Dynamically Alters the Expression Profiles of Inflammatory Adipokines with Tissue Specificity in Mice
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Cold exposure or β3-adrenoceptor agonist treatment induces the adipose tissues remodeling, relevant for beige adipogenesis within white adipose tissue (WAT). It remains unclear whether this process influences inflammatory adipokines expression in adipose tissues. We determine the temporal profile of cold or β3-adrenoceptor agonist (CL316,243)-induced changes in the expression of inflammatory adipokines in adipose tissues in […]
IJMS, Vol. 17, Pages 791: Circulating MicroRNAs as Biomarkers in Biliary Tract Cancers
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Biliary tract cancers (BTCs) are a group of highly aggressive malignant tumors with a poor prognosis. The current diagnosis is based mainly on imaging and intraoperative exploration due to brush cytology havinga low sensitivity and the standard markers, such as carcinoembryonic antigen (CEA) and carbohydrate 19-9 (CA19-9), not having enough sensitivity nor specificity to be […]
IJMS, Vol. 17, Pages 793: The Role of Proanthocyanidins Complex in Structure and Nutrition Interaction in Alfalfa Forage
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Alfalfa (Medicago sativa L.) is one of the main forages grown in the world. Alfalfa is a winter hardy, drought tolerant, N-fixing legume with a good longevity, high yield, high nutrient levels, high digestibility, unique structural to non-structural components ratio, high dry matter intake, and high animal productivity per hectare. However, its main limitation is […]
IJMS, Vol. 17, Pages 794: Gibberellic Acid: A Key Phytohormone for Spikelet Fertility in Rice Grain Production
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The phytohormone gibberellic acid (GA) has essential signaling functions in multiple processes during plant development. In the “Green Revolution”, breeders developed high-yield rice cultivars that exhibited both semi-dwarfism and altered GA responses, thus improving grain production. Most studies of GA have concentrated on germination and cell elongation, but GA also has a pivotal role in […]
Expression of OATP2B1 as determinant of drug effects in the microcompartment of the coronary artery
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Clinical success of coronary drug-eluting stents (DES) is hampered by simultaneous reduction of smooth muscle cell (HCASMC) and endothelial cell proliferation due to unspecific cytotoxicity of currently used compounds. Previous in vitro data showing SMC-specific inhibition of proliferation suggested that statins may be suitable candidates for DES. It was aim of this study to further […]
Dpp spreading is required for medial but not for lateral wing disc growth
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Drosophila Decapentaplegic (Dpp) has served as a paradigm to study morphogen-dependent growth control. However, the role of a Dpp gradient in tissue growth remains highly controversial. Two fundamentally different models have been proposed: the ‘temporal rule’ model suggests that all cells of the wing imaginal disc divide upon a 50% increase in Dpp signalling, whereas […]
mTORC1 and mTORC2 have largely distinct functions in Purkinje cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The mammalian target of rapamycin (mTOR) is a key regulator of cellular growth which associates with other proteins to form two multi-protein complexes called mTORC1 and mTORC2. Dysregulation of mTORC1 signalling in brain is implicated in neuropathological conditions such as autism spectrum or neurodegenerative disorders. Accordingly, allosteric mTOR inhibitors are currently in clinical trials for […]
Photoredox Properties of Homoleptic d6 Metal Complexes with the Electron-Rich 4,4′,5,5′-Tetramethoxy-2,2′-bipyridine Ligand
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
A synthetic procedure leading to 4,4′,5,5′-tetramethoxy-2,2′-bipyridine [(MeO)4bpy] was developed, and the first three metal complexes with this ligand were synthesized. A few ligand precursor compounds, the final ligand, and its homoleptic iron(II) complex were characterized structurally by X-ray diffraction. The combination of cyclic voltammetry, optical absorption, luminescence, and transient absorption spectroscopy provided detailed insight into […]
Ice nucleation active particles are efficiently removed by precipitating clouds
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Ice nucleation in cold clouds is a decisive step in the formation of rain and snow. Observations and modelling suggest that variations in the concentrations of ice nucleating particles (INPs) affect timing, location and amount of precipitation. A quantitative description of the abundance and variability of INPs is crucial to assess and predict their influence […]
Abstracts: 44th Annual Meeting of the Japanese Society for Wound Healing
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/25bchCd via IFTTT
Biomarkers to distinguish functional constipation from irritable bowel syndrome with constipation
Abstract Treatments for functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C) differ, but symptom criteria do not reliably distinguish between them; some regard FC and IBS-C as parts of a single constipation spectrum. Our goal was to review studies comparing FC and IBS-C to identify possible biomarkers that separate them. A systematic review identified 15 studies that compared physiologic tests in FC *vs* IBS-C. Pain thresholds were lower in IBS-C than FC for 3/5 studies and not different in 2/5. Colonic motility was decreased more in FC than IBS-C for... περισσότερα »
Drug-induced liver injury caused by iodine-131.
*Drug-induced liver injury caused by iodine-131.* Clin Mol Hepatol. 2016 May 20; Authors: Kim CW, Park JS, Oh SH, Park JH, Shim HI, Yoon JW, Park JS, Hong SB, Kim JM, Le TB, Lee JW Abstract Iodine-131 is a radioisotope that is routinely used for the treatment of differentiated thyroid cancer after total or near-total thyroidectomy. However, there is some evidence that iodine-131 can induce liver injury . Here we report a rare case of drug-induced liver injury (DILI) caused by iodine-131 in a patient with regional lymph node metastasis after total thyroidectomy. A 47-year-old woma... περισσότερα »
Hypopituitarism in the elderly: a narrative review on clinical management of hypothalamic-pituitary-gonadal, hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes dysfunction.
*Hypopituitarism in the elderly: a narrative review on clinical management of hypothalamic-pituitary-gonadal, hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes dysfunction.* J Endocrinol Invest. 2016 May 21; Authors: Curtò L, Trimarchi F Abstract Hypopituitarism is an uncommon and under-investigated endocrine disorder in old age since signs and symptoms are unspecific and, at least in part, can be attributed to the physiological effects of aging and related co-morbidities. Clinical presentation is often insidious being characterized by non-specific manifestat... περισσότερα »
Interleukin (IL)-24 transforms the tumor microenvironment and induces anticancer immunity in a murine model of colon cancer.
*Interleukin (IL)-24 transforms the tumor microenvironment and induces anticancer immunity in a murine model of colon cancer.* Mol Immunol. 2016 May 19;75:11-20 Authors: Ma YF, Ren Y, Wu CJ, Zhao XH, Xu H, Wu DZ, Xu J, Zhang XL, Ji Y Abstract Interleukin-24 (IL-24) is a novel tumor suppressor and can mediate the induction of Th1-type cytokines from peripheral blood mononuclear cells. The individual properties of IL-24 have been previously examined; however, its in vivo immunological consequences and antitumor properties have not been previously evaluated with respect to colon canc...περισσότερα »
High Femoral Anteversion Is Related to Femoral Trochlea Dysplasia.
*High Femoral Anteversion Is Related to Femoral Trochlea Dysplasia.* Arthroscopy. 2016 May 18; Authors: Liebensteiner MC, Ressler J, Seitlinger G, Djurdjevic T, El Attal R, Ferlic PW Abstract PURPOSE: To investigate the possible relation between femoral anteversion (AV) and trochlear morphology. METHODS: Among 560 available lower-limb computed tomography (CT) scans, those with previous fracture, arthroplasty, or osteotomy were excluded and 40 cases were randomly selected. The following 4 lines were determined from the CT scans: 1 through the center of the femoral head and neck; 1 ... περισσότερα »
Folate-conjugated gold nanoparticle as a new nanoplatform for targeted cancer therapy.
*Folate-conjugated gold nanoparticle as a new nanoplatform for targeted cancer therapy.* J Cancer Res Clin Oncol. 2016 May 21; Authors: Samadian H, Hosseini-Nami S, Kamrava SK, Ghaznavi H, Shakeri-Zadeh A Abstract Conventional cancer treatment methods suffer from many limitations such as non-specificity and low efficacy in discrimination between healthy and cancer cells. Recent developments in nanotechnology have introduced novel and smart therapeutic nanomaterials that basically take advantage of various targeting approaches. Targeted nanomaterials selectively bind to the cance...περισσότερα »
Effect of p16 Status on the Quality-of-Life Experience During Chemoradiation for Locally Advanced Oropharyngeal Cancer: A Substudy of Randomized Trial Trans-Tasman Radiation Oncology Group (TROG) 02.02 (HeadSTART).
*Effect of p16 Status on the Quality-of-Life Experience During Chemoradiation for Locally Advanced Oropharyngeal Cancer: A Substudy of Randomized Trial Trans-Tasman Radiation Oncology Group (TROG) 02.02 (HeadSTART).* Int J Radiat Oncol Biol Phys. 2016 Mar 23; Authors: Ringash J, Fisher R, Peters L, Trotti A, O'Sullivan B, Corry J, Kenny L, Van Den Bogaert W, Wratten C, Rischin D Abstract PURPOSE: Human papillomavirus-associated oropharyngeal cancer (OPC) has a favorable prognosis. Current research de-escalates treatment, aiming to improve quality of life (QOL). Understanding the ...περισσότερα »
High E6 Gene Expression Predicts for Distant Metastasis and Poor Survival in Patients With HPV-Positive Oropharyngeal Squamous Cell Carcinoma.
*High E6 Gene Expression Predicts for Distant Metastasis and Poor Survival in Patients With HPV-Positive Oropharyngeal Squamous Cell Carcinoma.* Int J Radiat Oncol Biol Phys. 2016 Mar 10; Authors: Khwaja SS, Baker C, Haynes W, Spencer CR, Gay H, Thorstad W, Adkins DR, Nussenbaum B, Chernock RD, Lewis JS, Wang X Abstract PURPOSE: Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) have a favorable prognosis. As a result, de-escalation clinical trials are under way. However, approximately 10% of patients will experience distant recurrence ... περισσότερα »
Radiation Therapy for Head and Neck Cancer and Angioneogenesis: Good for Cancer, Bad for Carotids?
*Radiation Therapy for Head and Neck Cancer and Angioneogenesis: Good for Cancer, Bad for Carotids?* JACC Cardiovasc Imaging. 2016 May 11; Authors: Arbustini E, Kodama T, Favalli V PMID: 27209104 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1U8Lam8
Plaque Neovascularization Is Increased in Human Carotid Atherosclerosis Related to Prior Neck Radiotherapy: A Contrast-Enhanced Ultrasound Study.
*Plaque Neovascularization Is Increased in Human Carotid Atherosclerosis Related to Prior Neck Radiotherapy: A Contrast-Enhanced Ultrasound Study.* JACC Cardiovasc Imaging. 2016 May 11; Authors: Shah BN, Gujral DM, Chahal NS, Harrington KJ, Nutting CM, Senior R Abstract OBJECTIVES: The aim of this study was to determine the effect of radiotherapy (RT) on intraplaque neovascularization (IPN) in human carotid arteries. BACKGROUND: Exposure of the carotid arteries to RT during treatment for head and neck cancer is associated with increased risk for stroke. However, the effect of RT o... περισσότερα »
TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens.
*TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens.* Allergol Int. 2016 May 18; Authors: Hiraishi Y, Nambu A, Shibui A, Nakanishi W, Yamaguchi S, Morita H, Iikura M, McKenzie AN, Matsumoto K, Sudo K, Yamasoba T, Nagase T, Nakae S Abstract BACKGROUND: T cell immunoglobulin domain and mucin domain-containing molecule 3 (TIM-3), which is preferentially expressed on Th1 cells rather than Th2 cells, is considered to be a negative regulator of Th1 cell function. This suggests that TIM-3 indirectly enhances Th2-type immune responses by sup...περισσότερα »
Physiologic and Acoustic Effects of Opera Performance.
*Physiologic and Acoustic Effects of Opera Performance.* J Voice. 2016 May 18; Authors: Kwak PE, Stasney CR, Hathway JR, Guffey D, Minard CG, Ongkasuwan J Abstract INTRODUCTION/HYPOTHESIS: Opera performance is physiological and emotional, and singing performers utilize their larynges in often strenuous ways. Historically, the training of a classical voice has been considered the paragon of healthy singing. However, the natural history of a performing larynx has not been studied systematically. There is paucity of scientific studies to guide practice patterns, particularly with reg... περισσότερα »
[Cranial trepanation in primitive cultures].
*[Cranial trepanation in primitive cultures].* Neurocirugia (Astur). 2016 May 18; Authors: González-Darder JM Abstract A review is presented on cranial trepanations performed by primitive cultures. The scientific interest in this topic began after the discovery in 1965 by Ephraim G. Squier of a pre-Columbian trepanated skull, and studied by Paul Broca in Paris. Pseudotrepanation and other types of cranial manipulation are reviewed. The techniques, technology, and instruments for every type of trepanation are well known. There are a surprisingly high percentage of cases showing si... περισσότερα »
Three-dimensional organotypic culture of human salivary glands: the slice culture model
Abstract Objective A challenge in studying human salivary glands is to maintain the cells ex vivo in their three-dimensional (3D) morphology with an intact native extracellular matrix (ECM) environment. This paper established a human salivary 3D-organotypic slice culture model that could maintain its physiological functions as well as allowing a direct visualization of the cells. Methods Human salivary biopsies from six patients were embedded in agarose and submerged in cold buffer for thin (50 *μ*m) sectioning using a vibratome. ‘Salivary slices’ were mechanically supported by a p... περισσότερα »
Do smear-layer removal agents affect the push-out bond strength of calcium-silicate based endodontic sealers?
Abstract Aim To evaluate the effect of 17% ethylenediaminetetracetic acid (EDTA), 2.25% Peracetic Acid (PA) or 10% Citric Acid (CA) on the push-out bond strength of calcium-silicate based endodontic sealers [MTA Fillapex (Angelus, Londrina, Brazil) and Total Fill BC Sealer (FKG, La Chaux-de-Fonds, Switzerland)] to root dentine after different periods of immersion in phosphate-buffered saline (PBS). AH Plus (Dentsply DeTrey, Konstaz, Germany) was used as a reference material for comparison. Methodology Thirty human maxillary incisors were selected and three 1-mm discs were obtained ...περισσότερα »
Evaluation of the in vitro biocompatibility of a new fast-setting ready-to-use root filling and repair material
Abstract Aim To evaluate the *in vitro* biocompatibility of iRoot FS (Innovative BioCeramix Inc., Vancouver, BC, Canada) and to compare its performance with those of iRoot BP Plus (Innovative BioCeramix Inc. Vancouver, BC, Canada) and ProRoot mineral trioxide aggregate (MTA; Dentsply Tulsa Dental, Tulsa, OK, USA). Methodology MC3T3-E1 cells were cultured for 1, 2 and 3 days in various dilutions of iRoot FS, iRoot BP Plus and MTA extracts after 7 days of setting to assess cell viability using a cell counting kit-8 (Dojindo, Kumamoto, Japan). The cell apoptosis induced by the set mat... περισσότερα »
Reversible hearing loss following cryptococcal meningitis: case study
Rapid Communication W L Neo, N Durisala, E C Ho The Journal of Laryngology & Otology,FirstView Article(s), 5 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #ORL via xlomafota13 on Inoreader http://ift.tt/1WKb8Qw via IFTTT
Does topical use of autologous serum help to reduce post-tonsillectomy morbidity? A prospective, controlled preliminary study
Research Articles M Kara, H Erdoğan, H B Altinişik, H Aylanç, O Güçlü, F S Dereköy The Journal of Laryngology & Otology,FirstView Article(s), 7 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #ORL via xlomafota13 on Inoreader http://ift.tt/1Tu2Kid via IFTTT
Age of onset of Ménière's disease in the Netherlands: data from a specialised dizziness clinic
Research Articles B F Van Esch, P P G Van Benthem, H J Van Der Zaag-Loonen, TJ D Bruintjes The Journal of Laryngology & Otology,FirstView Article(s), 4 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #ORL via xlomafota13 on Inoreader http://ift.tt/1Tu3dkF via IFTTT
Reversible hearing loss following cryptococcal meningitis: case study
Rapid Communication W L Neo, N Durisala, E C Ho The Journal of Laryngology & Otology,FirstView Article(s), 5 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #ENT via xlomafota13 on Inoreader http://ift.tt/1WKb8Qw via IFTTT
Does topical use of autologous serum help to reduce post-tonsillectomy morbidity? A prospective, controlled preliminary study
Research Articles M Kara, H Erdoğan, H B Altinişik, H Aylanç, O Güçlü, F S Dereköy The Journal of Laryngology & Otology,FirstView Article(s), 7 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #ENT via xlomafota13 on Inoreader http://ift.tt/1Tu2Kid via IFTTT
Age of onset of Ménière's disease in the Netherlands: data from a specialised dizziness clinic
Research Articles B F Van Esch, P P G Van Benthem, H J Van Der Zaag-Loonen, TJ D Bruintjes The Journal of Laryngology & Otology,FirstView Article(s), 4 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #ENT via xlomafota13 on Inoreader http://ift.tt/1Tu3dkF via IFTTT
Reversible hearing loss following cryptococcal meningitis: case study
Rapid Communication W L Neo, N Durisala, E C Ho The Journal of Laryngology & Otology,FirstView Article(s), 5 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #ENT via xlomafota13 on Inoreader http://ift.tt/1WKb8Qw via IFTTT
Does topical use of autologous serum help to reduce post-tonsillectomy morbidity? A prospective, controlled preliminary study
Research Articles M Kara, H Erdoğan, H B Altinişik, H Aylanç, O Güçlü, F S Dereköy The Journal of Laryngology & Otology,FirstView Article(s), 7 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #ENT via xlomafota13 on Inoreader http://ift.tt/1Tu2Kid via IFTTT
Age of onset of Ménière's disease in the Netherlands: data from a specialised dizziness clinic
Research Articles B F Van Esch, P P G Van Benthem, H J Van Der Zaag-Loonen, TJ D Bruintjes The Journal of Laryngology & Otology,FirstView Article(s), 4 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #ENT via xlomafota13 on Inoreader http://ift.tt/1Tu3dkF via IFTTT
Free fatty acids sensitize dendritic cells to amplify TH1/TH17-immune responses
[image: cover.gif?v=1&s=da614e72e3219d8335c602a9] Obesity is associated with body fat gain and impaired glucose metabolism. Here, we identified both body fat gain in obesity and impaired glucose metabolism as two independent risk factors for increased serum levels of free fatty acids (FFAs). Since obesity is associated with increased and/or delayed resolution of inflammation observed in various chronic inflammatory diseases such as psoriasis, we investigated the impact of FFAs on human monocyte-derived and mouse bone marrow-derived dendritic cell (DCs) functions relevant for the p...περισσότερα »
IJMS, Vol. 17, Pages 771: Analysis of 2-(2-Phenylethyl)chromones by UPLC-ESI-QTOF-MS and Multivariate Statistical Methods in Wild and Cultivated Agarwood
[image: ag] Agarwood is the fragrant resinous material mainly formed from species of Aquilaria. 2-(2-phenylethyl)chromones, especially the highly oxidized 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones, are the main representative compounds from agarwood. It is important to determine whether agarwood in trade is from cultivated trees or natural trees in the Convention on the International Trade in Endangered Species (CITES). We characterized the 2-(2-phenylethyl)chromones in agarwood by ultra-performance liquid chromatography coupled with electrospray ionization mass spectrometry (... περισσότερα »
Biology, Vol. 5, Pages 22: Effect of Different Broad Waveband Lights on Membrane Lipids of a Cyanobacterium, Synechococcus sp., as Determined by UPLC-QToF-MS and Vibrational Spectroscopy
Differential profile of membrane lipids and pigments of a Synechococcus sp. cyanobacterial strain cells exposed to blue, green, red and white light are determined by means of liquid chromatography and mass spectrometry or diode array detection. Raman and ATR-IR spectra of intact cells under the diverse light wavebands are also reported. Blue light cells exhibited an increased content of photosynthetic pigments as well as specific species of membrane glycerolipids as compared to cells exposed to other wavebands. The A630/A680 ratio indicated an increased content of phycobilisomes (P...περισσότερα »
Molecules, Vol. 21, Pages 679: New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.
[image: ag] A new rare casbane-type diterpenoid 1 and two new cembrane diterpenoids 2, 3 were isolated from an Okinawan soft coral, Lobophytum sp., together with four known cembrane diterpenoids 4–7. Their structures were elucidated by extensive analysis of spectroscopic data (1D and 2D NMR, IR, and MS) and a molecular modeling study. The new isolates showed weak anti-bacterial activity, mild cytotoxicity against HCT116 cells, and anti-inflammatory effect in LPS/IFN-γ-stimulated RAW 264.7 macrophage cells. from #Medicine via ola Kala on Inoreader http://ift.tt/1Wc6iLL via IFTTT
Steamed and Fermented Ethanolic Extract from Codonopsis lanceolata Attenuates Amyloid-β-Induced Memory Impairment in Mice
Codonopsis lanceolata (C. lanceolata) is a traditional medicinal plant used for the treatment of certain inflammatory diseases such as asthma, tonsillitis, and pharyngitis. We evaluated whether steamed and fermented C. lanceolata (SFC) extract improves amyloid-β- (Aβ-) induced learning and memory impairment in mice. The Morris water maze and passive avoidance tests were used to evaluate the effect of SFC extract. Moreover, we investigated acetylcholinesterase (AChE) activity and brain-derived neurotrophic factor (BDNF), cyclic AMP response element-binding protein (CREB), and extra...περισσότερα »
Implementing Pharmacogenomics at Your Institution: Establishment and Overcoming Implementation Challenges
With advancements in pharmacogenomics research and genotyping technology, implementation of pharmacogenomics into clinical practice is now feasible. The aim of this publication is to serve as a tutorial for institutions interested in developing pharmacogenomics services. Topics covered include resources needed, clinical decision support establishment, choosing a genotyping platform, and challenges faced with pharmacogenomics service implementation. This tutorial provides practical advice, drawing upon experience of two established clinical pharmacogenomics services. This article ... περισσότερα »
The Interface of Syntax with Pragmatics and Prosody in Children with Autism Spectrum Disorders.
*The Interface of Syntax with Pragmatics and Prosody in Children with Autism Spectrum Disorders.* J Autism Dev Disord. 2016 May 21; Authors: Terzi A, Marinis T, Francis K Abstract In order to study problems of individuals with Autism Spectrum Disorders (ASD) with morphosyntax, we investigated twenty high-functioning Greek-speaking children (mean age: 6;11) and twenty age- and language-matched typically developing children on environments that allow or forbid object clitics or their corresponding noun phrase. Children with ASD fell behind typically developing children in comprehen... περισσότερα »
Listening to the calls of the wild: The role of experience in linking language and cognition in young infants.
*Listening to the calls of the wild: The role of experience in linking language and cognition in young infants.* Cognition. 2016 May 19;153:175-181 Authors: Perszyk DR, Waxman SR Abstract Well before they understand their first words, infants have begun to link language and cognition. This link is initially broad: At 3months, listening to both human and nonhuman primate vocalizations supports infants' object categorization, a building block of cognition. But by 6months, the link has narrowed: Only human vocalizations support categorization. What mechanisms underlie this rapid tun... περισσότερα »
The Interface of Syntax with Pragmatics and Prosody in Children with Autism Spectrum Disorders.
*The Interface of Syntax with Pragmatics and Prosody in Children with Autism Spectrum Disorders.* J Autism Dev Disord. 2016 May 21; Authors: Terzi A, Marinis T, Francis K Abstract In order to study problems of individuals with Autism Spectrum Disorders (ASD) with morphosyntax, we investigated twenty high-functioning Greek-speaking children (mean age: 6;11) and twenty age- and language-matched typically developing children on environments that allow or forbid object clitics or their corresponding noun phrase. Children with ASD fell behind typically developing children in comprehen... περισσότερα »
