Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma

Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) has an improved outcome and may allow for treatment de-escalation. High-risk HPV (HR-HPV) infection is associated with deregulat...

https://ift.tt/2QeP40F

Trigeminal neuralgia associated with ophthalmic surgery: a case series

Trigeminal neuralgia is a rare cause of postoperative pain after ophthalmic surgery and has only been described twice in the international literature: one case of pain after vitrectomy with a crystalline lens ...

https://ift.tt/2NsmTNi

The impact of the number of harvested central lymph nodes on the lymph node ratio

The purpose of this study was to analyze the impact of lymph node harvest on the lymph node ratio (LNR).

https://ift.tt/2Qb2JGa

Vibrant Soundbridge implantation via a retrofacial approach in a patient with congenital aural atresia

A method of Vibrant Soundbridge (VSB) placement to the round window (RW) via the retrofacial approach with preoperative evaluation of the relationship between the facial nerve (FN) and RW by 3D-CT reconstruction was proposed for the treatment of congenital aural atresia (CAA) patient.

https://ift.tt/2CxL0px

The accuracy of virtual-surgical-planning-assisted treatment of hemifacial microsomia in adult patients: distraction osteogenesis vs. orthognathic surgery

Hemifacial microsomia (HFM) is a common congenital craniofacial deformity with a high prevalence. Orthognathic surgery and distraction osteogenesis are two conventionally used treatments of HFM. The main objective of this retrospective study was to evaluate the accuracy of two treatments with the help of virtual surgical planning in adult HFM patients. Sixty-eight adult patients with unilateral HFM were enrolled in this study. Preoperative surgical planning and simulation were performed on three-dimensional computed tomography models.

https://ift.tt/2N0HLfq

88thAnnual Meeting of the American Thyroid Association October 3–7, 2018 Marriott Marquis, Washington, DC

Thyroid, Ahead of Print.


https://ift.tt/2MSyGoN

Primary classic Hodgkin lymphoma of the ileum and Epstein-Barr virus mucocutaneous ulcer of the colon: two entities compared

Abstract

Primary classic Hodgkin lymphoma of the gastrointestinal tract represents a rare occurrence. A full patient's work-up is essential in order to exclude a secondary intestinal involvement. Histologically Epstein-Barr virus mucocutaneous ulcer closely resembles Hodgkin lymphoma. The differential diagnosis between these two entities is relevant, since both the therapeutic approach and the clinical behavior are different. Herein, we describe a case of primary classic Hodgkin lymphoma arising in the ileum and a case of Epstein-Barr virus mucocutaneous ulcer of the colon, focusing on the main clinicopathological differences.

https://ift.tt/2wQbEos

Blood Sample Collection to Evaluate Biomarkers in Subjects With Untreated Solid Tumors

Conditions:   Breast Cancer;   Lung Cancer;   Colorectal Cancer;   Prostate Cancer;   Bladder Cancer;   Uterine Cancer;   Kidney Cancer;   Renal Pelvis Cancer;   Pancreatic Cancer;   Liver Cancer;   Stomach Cancer;   Ovarian Cancer;   Esophageal Cancer
Intervention:   Other: Blood Sample Collection
Sponsor:   Exact Sciences Corporation
Recruiting

https://ift.tt/2CvEi3r

Effect of Guided Imagery for Radiotherapy-Related Distress in Patients With Head and Neck Cancer

Condition:   Head and Neck Cancer
Interventions:   Behavioral: Guided Imagery;   Other: Treatment as Usual
Sponsor:   University of Colorado, Denver
Not yet recruiting

https://ift.tt/2Q9PHIV

Relevante Interaktionen von Analgetika und Koanalgetika mit onkologischen Systemtherapeutika – wann wird es gefährlich?

Zusammenfassung

Hintergrund

Schmerz ist ein gefürchtetes und zugleich auch das häufigste Symptom bei Krebspatienten. Gleichzeitig ist es aber etwas, für dessen Behandlung effektive und gut verträgliche Medikamente zur Verfügung stehen. Da behandlungsbedürftige Schmerzen in jeder Phase der Erkrankung auftreten können, werden Schmerztherapie und tumorgerichtete Systemtherapie häufig gleichzeitig durchgeführt. Während die Zahl der verfügbaren analgetisch wirksamen Substanzen seit Jahrzehnten stagniert (es wurden lediglich neue galenische Zubereitungen entwickelt), entwickelt sich der Markt der verfügbaren und oft hoch wirksamen Onkologika nahezu explosionsartig. Damit steigt auch die Wahrscheinlichkeit klinisch relevanter und u. U. sogar tödlicher „drug-drug-interactions". Ein Drittel aller ambulanten onkologischen Patienten soll ein Risiko für das Auftreten einer Interaktion haben. Eine Sonderstellung nimmt hierbei Methadon ein, für dessen Antitumorwirkung es bis dato keinen wissenschaftlichen Beweis gibt, wohl aber für sein hohes Risikoprofil.

Ziel

Ziel dieses Artikels ist die Sensibilisierung des Onkologen und Palliativmediziners für die Bedeutung von Interaktionen. Exemplarisch werden einzelne Interaktionen erläutert und bewertet. Keineswegs wird an dieser Stelle der Anspruch auf Vollständigkeit erhoben. Hierzu wird auf (frei verfügbare) Datenbanken verwiesen.

Material und Methoden

Dieser Beitrag wurde unter Bezug auf die wissenschaftlichen Fachinformationen der erwähnten Substanzen, klinische Erfahrungsberichte sowie unter Zuhilfenahme einschlägiger Interaktionsportale erstellt. Die Auswahl der Substanzen erfolgte auf der Basis langjähriger internistisch onkologischer Erfahrung und der S3-Leitlinie Schmerz des Leitlinienprogramms Onkologie der AWMF (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V.)

https://ift.tt/2QcQaKl

Precise control of maxillary multidirectional movement in Le Fort I osteotomy using a surgical guiding device

Publication date: Available online 6 September 2018

Source: British Journal of Oral and Maxillofacial Surgery

Author(s): C. Xue, H. Xu, Y. Tian, X. Yang, E. Luo, D. Bai

Abstract

We introduced a surgical protocol to achieve accurate maxillary multidirectional movement in Le Fort I osteotomies. This comprised a way of controlling precision and a guiding device together with prebent titanium plates. We evaluated the protocol using a semiautomated 3-dimensional assessment in 22 patients with maxillary multidirectional movement (movement in three or more of six directions). Operations were all done between October 2015 and April 2017 by the same surgeon, who followed the protocol strictly. To evaluate the accuracy, we measured the deviation of the orientation of landmarks and of the upper dentition. All cases were followed up for at least a year. They all involved maxillary movement in at least three directions, and nine involved movement in six. The guiding device was used intraoperatively in all cases. Vertical deviation of the segments of bone was often detected during removal of bone, and sagittal deviation in three cases, but we found no transverse deviations. The assessment of accuracy showed that the mediolateral, anteroposterior, and superoinferior translations of landmarks were all less than 1 mm, with mean values of 0.29, 0.43, and 0.39 mm, respectively. The pitch, roll, and yaw of the upper dentition were also less than 1°, with mean values of 0.60°, 0.35°, 0.36°, respectively. The proposed protocol allowed accurate reposition of the maxilla with multidirectional movement during Le Fort I osteotomy.

https://ift.tt/2NWlnjo

Erratum zu: Europäische PanCare-Studien zu Spätfolgen nach Krebs im Kindes- und Jugendalter

Erratum zu:

Der Onkologe 2018

https://ift.tt/2QbXCFC

Im vorletzten Abschnitt zur Überschrift „Projekte PanCareSurFup und PanCareLIFE" muss es korrekt heißen (Ergänzung in kursiv):

… Von den 25 datenbereitstellenden Einrichtungen wurden demografische, klinische (z. B. zur …

https://ift.tt/2CBZrJ8

Commentary: Dimensions of the maxillary sinus drainage system associated with pathology of the sinus

Publication date: Available online 6 September 2018

Source: Archives of Oral Biology

Author(s): Yongchun Gu

https://ift.tt/2oOVEhY

Commentary: Dimensions of the maxillary sinus drainage system associated with pathology of the sinus

Publication date: Available online 6 September 2018

Source: Archives of Oral Biology

Author(s): Yongchun Gu

https://ift.tt/2oOVEhY

MCM3: A reliable proliferation marker in odontogenic cysts and ameloblastoma

Publication date: Available online 6 September 2018

Source: Journal of Oral Biology and Craniofacial Research

Author(s): Zohreh Jaafari Ashkavandi, Fatemeh Mehranmehr, Elham Roosta

Abstract

Background

MCM3 is a marker of proliferation that has been used as a diagnostic or prognostic marker in many pathologic lesions.

Purpose

The purpose of this study is to investigate the proliferative activity of dentigerous cysts, odontogenic keratocyst and ameloblastoma using minichromosome maintenance 3 (MCM3) and compare it with Ki-67 proliferation marker.

Methods

In this cross-sectional study, 40 cases including 11 cases of dentigerous cyst, 14 odontogenic keratocyst, and 15 ameloblastoma were included. Immunohistochemical expression of MCM3 and Ki-67 were investigated and compared statistically using ANOVA, Chi-square, Tukey and Spearman's correlation tests.

Results

All subjects were positive for Ki-67 and MCM3. There was a significant difference in MCM3 and Ki-67 expression among all groups. Compared to Ki-67, MCM3 exhibited a higher level of expression. Ameloblastoma and odontogenic keratocyst revealed higher expression rate of both markers in comparison to dentigerous cysts.

Conclusion

The results showed MCM3 expression in the most common odontogenic cysts and tumors, especially more aggressive lesions. This marker might have a role in pathogenesis of these lesions and could be a reliable marker for assessing proliferation activity.

https://ift.tt/2Q8B48Z

Evaluation of the expression of Glypican-3 in benign and malignant salivary gland tumors

Publication date: Available online 6 September 2018

Source: Journal of Oral Biology and Craniofacial Research

Author(s): Azadeh Andisheh-Tadbir, Mohammad Javad Ashraf, Ali Gudarzi, Razieh Zare

Abstract

Introduction

Glypican-3 (GPC3) is involved in regulation of cell proliferation and morphogenesis. It is abundant in embryonic tissue, but limited in most adult tissues. GPC3 deletion or mutation can disturb the balance between cell apoptosis and proliferation, which may result in tumorigenesis. This study aimed to investigate the GPC3 expression in salivary gland tumors (SGTs) and the adjacent non-neoplastic tissues.

Methods

This study reviewed 50 samples of salivary tumors from the archive of Khalili Hospital, Shiraz, Iran, including 17 cases of pleomorphic adenoma (PA), 16 cases of mucoepidermoid carcinoma (MEC), and 17 cases of adenoid cystic carcinoma (ACC); as well as a control group of 23 cases of normal salivary gland tissues. GPC3 expression was investigated through immunohistochemistry.

Results

GPC3 expression was significantly higher in malignant tumors (MEC and ACC) than in PA, and higher in PA than in the normal salivary glands (P < 0.001). The expression intensity was moderate to strong in malignant tumors and weak to moderate in benign tumors. No strong positivity was observed in normal salivary gland tissues (P < 0.001). Nor was any association detected between the GPC3 expression and intensity with the clinicopathologic parameters.

Conclusion

Although GPC3 overexpression was observed at the protein level in SGTs, and its expression was not related with the clinicopathologic factors, the potential use of GPC3 for diagnostic, therapeutic, and prognostic purposes requires further investigations.

https://ift.tt/2NWaSN2

Corneal Blood Staining after Complicated Cataract Surgery

Purpose: To report the case of a patient with corneal blood staining after a complicated cataract surgery. Observations: We report on a 68-year-old woman who developed corneal blood staining secondary to hyphema after cataract surgery, despite the fact that intraocular pressure was not increased for a prolonged time. The corneal staining spontaneously cleared from the periphery towards the center. It was fully resolved after 2.5 years of follow-up. Conclusions and Importance: In case of hyphema induced by cataract surgery, performance of early anterior chamber washout should be considered to prevent corneal blood staining and poor visual outcome.
Case Rep Ophthalmol 2018;9:421–424

https://ift.tt/2CtY4fG

CISH is a negative regulator of IL-13-induced CCL26 production in lung fibroblasts

Publication date: Available online 6 September 2018

Source: Allergology International

Author(s): Hideyuki Takeshima, Masafumi Horie, Yu Mikami, Kosuke Makita, Naoya Miyashita, Hirotaka Matsuzaki, Satoshi Noguchi, Hirokazu Urushiyama, Yoshihisa Hiraishi, Akihisa Mitani, Zea Borok, Takahide Nagase, Yasuhiro Yamauchi

Abstract

Background

Bronchial asthma is a chronic airway disease characterized by eosinophilic airway inflammation. Lung fibroblasts activated by IL-13 serve as important sources of chemokines, such as eotaxins, contributing to persistent eosinophilic inflammation. Src-homology 2-containing protein (CISH), belonging to the suppressor of cytokine signaling (SOCS) family, acts as a negative regulator of cytokine induction. The aim of this study was to elucidate the role of CISH in the production of eosinophil chemotactic chemokines in human lung fibroblasts.

Methods

Normal human lung fibroblasts were stimulated by IL-13, and global gene expression profile was assessed by cDNA microarray. Expression changes and downstream of IL-13 signaling were evaluated by quantitative RT-PCR, ELISA or western blotting. Loss- and gain-of-function analyses of CISH were performed by small interfering RNA and vector overexpression, respectively.

Results

Ingenuity pathway analysis revealed that IL-13 induced chemokine signaling, including the eotaxin family, while significantly suppressing IFN-α/β signaling. Among eight SOCS family members, CISH was most strongly induced by IL-13 via phosphorylation of signal transducer and activator of transcription 6 (STAT6). Loss- and gain-of-function studies demonstrated that CISH negatively regulated the expression of CCL26.

Conclusions

These findings suggest that CISH plays a key role in the eosinophilic inflammation associated with bronchial asthma by regulating IL-13-induced CCL26 production. Augmentation of CISH function could be a novel approach for treating eosinophilic inflammation in severe asthma.

https://ift.tt/2NXmCz8

Nécroses digitales révélant une maladie des agglutinines froides : traitement par rituximab

Publication date: Available online 7 September 2018

Source: Annales de Dermatologie et de Vénéréologie

Author(s): T. Klejtman, B. Garel, P. Senet, L. Tribout, C. Bachmeyer, A. Barbaud, J.-B. Monfort

Résumé

Introduction

Les nécroses des doigts sont rares en comparaison de celles des membres inférieurs. Elles sont une urgence médico-chirurgicale. Un bilan étiologique approfondi est indispensable. La maladie des agglutinines froides est une cause rare de nécroses digitales, de diagnostic difficile et souvent non recherchée.

Observation

Nous rapportons le cas d'un homme de 57 ans qui présentait un phénomène de Raynaud de la main gauche d'apparition récente, compliqué secondairement de nécroses digitales survenues après exposition professionnelle au froid (conducteur d'un chariot de manutention). Le bilan étiologique permettait de poser le diagnostic de maladie des agglutinines froides idiopathique. Un traitement par rituximab et des soins locaux ont permis une cicatrisation complète.

Discussion

La maladie des agglutinines froides est une cause rare d'anémie hémolytique auto-immune. Les signes cliniques cutanés, paroxystiques, déclenchés par le froid, sont au premier plan. Il existe une forme idiopathique et une forme secondaire à une hémopathie lymphoïde chronique, une maladie auto-immune ou une infection ; un bilan étiologique est indispensable. Le traitement qui permet d'obtenir le meilleur taux de réponse, associé à une bonne tolérance, est à ce jour le rituximab en perfusions hebdomadaires pendant 1 mois.

Summary

Background

Digital necrosis is rarer than lower limb necrosis and constitutes a medical or surgical emergency. Etiological evaluation is required. Cold agglutinin disease is a cause of digital necrosis but diagnosis is difficult.

Patients and methods

Herein we report the case of a 57-year-old man presenting recent paroxysmal acrosyndrome of the left hand subsequently complicated by digital necrosis following occupational exposure to cold in his work as a forklift driver. After etiological evaluation, a diagnosis of primary cold agglutinin disease was made. Intravenous rituximab and topical treatment resulted in complete healing.

Discussion

Cold agglutinin disease is a rare type of auto-immune hemolytic anemia. Following exposure to cold, paroxysmal cutaneous signs are frequent. The disease may be either primary or secondary with B-cell lymphoproliferative disorder, auto-immune disease or infection. A thorough workup is required. To date, the treatment combining the best positive response rate and good safety is rituximab in weekly perfusions over a 1-month period.

https://ift.tt/2NYnIux

Efficacité spectaculaire de l’ivermectine topique dans un cas de granulome facial aseptique idiopathique

Publication date: Available online 6 September 2018

Source: Annales de Dermatologie et de Vénéréologie

Author(s): E. Blind, N. Ropars, G. Safa

https://ift.tt/2wRb3D3

Shared Decision Making for the Allergist

In the age of personalized medicine, patients are playing a greater role in their treatment decisions. The internet has allowed patients to better educate themselves about their health and come prepared to office visits with questions and opinions. In a survey of 300 patients who attended an allergy clinic, 53% indicated they searched online for information on allergy before their consultation.1 In consideration of the informed patient and increasing patient empowerment in healthcare decisions, personalized medicine cannot be implemented without shared decision making (SDM) between patients and healthcare providers.

https://ift.tt/2CtfKb9

The therapeutic effects of lipoxin A4 during treadmill exercise on monosodium iodoacetate-induced osteoarthritis in rats

Publication date: November 2018

Source: Molecular Immunology, Volume 103

Author(s): Yue Yang, Yang Wang, Yawei Kong, Xiaoning Zhang, He Zhang, Yi Gang, Lunhao Bai

Abstract

Lipoxin A₄ (LXA₄), a kind of adipokines, is a potent stop signal of inflammation. Our preliminary study found that LXA₄ of serum and intra-articular lavage fluid (IALF) was rapidly elevated in 2 h and rapidly reduced to normal level at 4 h after moderate-intensity treadmill exercise. The aim was to confirm the therapeutic effects of LXA₄ during treadmill exercise on rat model of monosodium iodoacetate (MIA)-induced OA and the detailed mechanism of LXA₄ on OA. One hundred and twenty-four male Sprague-Dawley rats were submitted to two different protocols. A single session of treadmill exercise: sixty-four rats were randomly divided into treadmill exercise of different intensities for 60 min only once (n = 4). Formal treadmill exercise: sixty rats were randomly divided into six groups (n = 10): control group (CG), knee OA group (OAG), OA with treadmill exercise of different intensities (OAL, OAM and OAH), and OAM + BOC-2 (an antagonist of LXA₄ receptor). The rats were evaluated by ELISA, histology, immunohistochemistry and western blotting. Fibroblast-like synoviocytes (FLSs) were obtained from knee joint of rats. The effects of LXA₄ on interleukin (IL)-1β induced FLSs were evaluated by western blotting and immunofluorescence. The results of ELISA, histological evaluation, western blotting and immunohistochemistry indicated that OAM had a better treatment which could be suppressed by BOC-2. Moreover, LXA₄ could attenuate the expression of matrix metalloproteinase (MMP)-3 and MMP-13 and suppress the expression of nuclear factor-kappa B (NF-κB) p65 induced by IL-1β in FLSs. The therapeutic effects of LXA₄ during treadmill exercise on MIA-induced OA via inhibiting NF-κB signaling pathway.

https://ift.tt/2oMjbjJ

Biological function of SPNS2: From zebrafish to human

Publication date: November 2018

Source: Molecular Immunology, Volume 103

Author(s): Xiao Zhu, Kun Ren, Yong-Zhi Zeng, Zhi Zheng, Guang-Hui Yi

Abstract

Sphingosine-1-phosphate (S1P), a bioactive metabolite of sphingolipid, has an important role in lymphocyte trafficking, immune responses, vascular and embryonic development, cancer, bone homeostasis, etc. S1P is produced intracellularly and then secreted into the circulation to engage in the above physiological or pathological processes by regulating the proliferation, differentiation and survival of target cells; however, the underlying mechanisms of S1P secretion and function remain poorly understood. Recently, Spinster 2 (SPNS2), a newly identified transporter of S1P, was shown to act as a mediator of intracellular S1P release and play an important role in the regulation of S1P. In this review, we focus on the primary biological characteristics and functions of SPNS2 and provide novel insights into the development of therapies for S1P-related disorders.

https://ift.tt/2M7mZ8c

Revealing the protective and pathogenic potential of MAIT cells

Publication date: November 2018

Source: Molecular Immunology, Volume 103

Author(s): Criselle D'Souza, Zhenjun Chen, Alexandra J. Corbett

Abstract

Mucosal-associated Invariant T (MAIT) cells represent a large proportion of T cells in human blood, and are also present throughout the body, being concentrated at mucosal sites. Their high level of conservation throughout mammalian evolution and recognition of conserved microbial antigens, derived from precursors of riboflavin (vitamin B2) biosynthesis, suggest an important role in protective immunity to pathogens. However, the picture that is emerging of MAIT cell immune function is increasingly complex, with numerous correlations of MAIT cell numbers with human diseases, and with recent studies demonstrating their pathogenic potential. The conditions that drive MAIT cell responses towards a protective versus pathogenic role are only beginning to be deciphered and, yet, must be understood for any attempt to harness MAIT cells therapeutically. In this review we summarise our current knowledge of immune protection and pathology driven by MAIT cells, models used to study their role in immunity and steps towards elucidating the immune signals driving these responses.

Graphical abstract

https://ift.tt/2wQgiTu

Pathophysiology and inhibition of IL-23 signaling in psoriatic arthritis: A molecular insight

Publication date: Available online 6 September 2018

Source: Clinical Immunology

Author(s): Cuong Thach Nguyen, Yehudi Bloch, Katarzyna Składanowska, Savvas N. Savvides, Iannis E. Adamopoulos

Abstract

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis of unknown etiology, and currently the cellular and molecular interactions that dictate its pathogenesis remain elusive. A role of the interleukin-23 (IL-23)/IL-23R (IL-23 receptor) interaction in the development of psoriasis and PsA is well established. As IL-23 regulates the differentiation and activation of innate and adaptive immunity, it pertains to a very complex pathophysiology involving a plethora of effectors and transducers. In this review, we will discuss recent advances on the cellular and molecular pathophysiological mechanisms that regulate the initiation and progression of PsA as well as new therapeutic approaches for IL-23/IL-23R targeted therapeutics.

https://ift.tt/2NWbtye

Corrigendum to “The role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck” [Oral Oncol. 81 (2018) 100–108]

Publication date: Available online 7 September 2018

Source: Oral Oncology

Author(s): Vassiliki Saloura, Theodore Vougiouklakis, Kyunghee Burkitt, Yusuke Nakamura, Gordon L. Hager, Carter van Waes

https://ift.tt/2wOtsQ1

Potential clinical implications of HPV status and expressions of p53 and cyclin D1 among oropharyngeal cancer patients

Journal of Oral Pathology &Medicine, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MRv4U1

Issue Information

Journal of Oral Pathology &Medicine, Volume 47, Issue 8, Page ii-v, September 2018.


https://ift.tt/2wRYDd1

Cover Image

Journal of Oral Pathology &Medicine, Volume 47, Issue 8, Page i-i, September 2018.


https://ift.tt/2MSO1FM

Panorama Dermatologische Praxis

https://ift.tt/2M77mxy

Es brennt uns wieder auf den Nägeln

https://ift.tt/2oKSsE9

Tinea faciei durch Nannizzia persicolor

Zusammenfassung

Wir berichten über eine Tinea faciei durch Nannizzia (N.) persicolor. Der 4‑jährige Junge hatte sich vermutlich an einem Meerschweinchen infiziert. Gesicherte Infektionen durch N. persicolor sind in Deutschland sehr selten. Möglicherweise wird dieser zoo- und geophile Dermatophyt aber aufgrund seiner Ähnlichkeit mit Trichophyton (T.) mentagrophytes auch nur selten erkannt. Die diagnostischen Merkmale von N. persicolor und seine Unterscheidung von T. mentagrophytes werden deshalb dargestellt. Insbesondere bei Kontakt zu Nagetieren sollte auch an N. persicolor gedacht werden.

https://ift.tt/2McJyJ2

Bullosis diabeticorum

Zusammenfassung

Wir berichten über 2 Patienten mit Diabetes mellitus, bei denen sich an den Fingern oder Zehen bis zu 2 cm durchmessende Blasen entwickelten, die nach Ausschluss der zu diskutierenden Differenzialdiagnosen als Bullosis diabeticorum (BD) eingeordnet werden konnten. Die BD ist eine seltene Blasenbildung, die bei Menschen mit Diabetes hauptsächlich palmoplantar beobachtet wird. Das klinische Bild ist gekennzeichnet durch bis zu 10 cm durchmessende, prallelastisch gefüllte Blasen mit klarem bis hämorrhagischem Inhalt. Die Abheilung erfolgt narbenlos, seltener unter Hinterlassung postinflammatorischer Pigmentierung oder zarter Narben. Histopathologisch finden sich sowohl intra- als auch subepidermale Spaltbildungen bei weitgehend fehlendem entzündlichen Infiltrat. Die Ätiopathogenese der BD ist nicht geklärt.

https://ift.tt/2oOjdHJ

Schmerzhafte rezidivierende Ulzerationen am Bein

https://ift.tt/2NWioYz

Type 1 Laryngeal Cleft and feeding and swallowing difficulties in infants and toddlers: A Review

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2oM4lK3

A comprehensive analysis of the allergenicity and IgE epitopes of myosinogen allergens in Scylla paramamosain

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2NS7q67

Is the Duodenum Trustworthy?

No abstract available

https://ift.tt/2Nuw1Bi

“Over the Internet” sale of prescription‐level topical corticosteroids and dilemma of dermatologists

International Journal of Dermatology, EarlyView.


https://ift.tt/2wKURlG

Activation of melanoblasts and melanocytes after treatment with monochromatic excimer light and narrowband‐ultraviolet B of skin of vitiligo patients

International Journal of Dermatology, EarlyView.


https://ift.tt/2NpKsWX

Nodular fasciitis, a forgotten entity

International Journal of Dermatology, EarlyView.


https://ift.tt/2wSTbXq

Correlation of clinical and pathologic evaluation of scarring alopecia

International Journal of Dermatology, EarlyView.


https://ift.tt/2Niod5x

Pemphigus foliaceus induced by topical imiquimod treatment

International Journal of Dermatology, EarlyView.


https://ift.tt/2wPg4eo

Issue Information

International Journal of Dermatology, Volume 57, Issue 10, Page i-iii,1147-1148, October 2018.


https://ift.tt/2Nn39e0

Temporal trends in prenatal risk factors for the development of infantile hemangiomas

Pediatric Dermatology, EarlyView.


https://ift.tt/2NpKnCD

Chronic granulomatous skin lesions leading to a diagnosis of TAP1 deficiency syndrome

Pediatric Dermatology, EarlyView.


https://ift.tt/2MSEkam

Management of a rare presentation of Kindler disease with digital constriction bands—Case report

Pediatric Dermatology, EarlyView.


https://ift.tt/2wOuYS9

Teaching and Learning Tips 12: Peer observation of teaching

International Journal of Dermatology, Volume 57, Issue 10, Page 1233-1236, October 2018.


https://ift.tt/2Mcv8Zq

Trimethoprim‐sulfamethoxazole‐induced drug reaction with eosinophilia and systemic symptoms in a child with congenital renal disease

Pediatric Dermatology, EarlyView.


https://ift.tt/2wLtIzc

Thyroid dermopathy and acropachy in pediatric patients

Pediatric Dermatology, EarlyView.


https://ift.tt/2NmMQhk

Neonatal urticaria: Could it be CAPS?

Pediatric Dermatology, EarlyView.


https://ift.tt/2M88Ibp

A unique case of pressure‐induced alopecia following EEG monitoring

Pediatric Dermatology, EarlyView.


https://ift.tt/2Np30GN

Subcutaneous fat necrosis of the newborn and associated hypercalcemia: A systematic review of the literature

Pediatric Dermatology, EarlyView.


https://ift.tt/2M5q2Oo

Diffuse cutaneous mastocytosis: Case report and literature review

Pediatric Dermatology, EarlyView.


https://ift.tt/2NqsMup

Natural history and extracutaneous involvement of congenital morphea: Multicenter retrospective cohort study and literature review

Pediatric Dermatology, EarlyView.


https://ift.tt/2M7LXV8

Surgical treatment outcomes of infantile hemangioma in children: Does prior medical treatment matter

Pediatric Dermatology, EarlyView.


https://ift.tt/2NmcEKw

Cytomegalovirus ulcers following radiotherapy for a Marjolin ulcer in a renal transplant recipient

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2CuwMG9

Author Index 2018

Australasian Journal of Dermatology, Volume 59, Issue S2, Page 24-24, August 2018.


https://ift.tt/2MVANs0

Issue Information

Australasian Journal of Dermatology, Volume 59, Issue S2, Page 1-2, August 2018.


https://ift.tt/2Csibe3

WCCS18 World Congress on Cancers of the Skin 2018 Sydney International Convention Centre 15‐18 August 2018

Australasian Journal of Dermatology, Volume 59, Issue S2, Page 3-23, August 2018.


https://ift.tt/2Nr4UXw

Systemic treatments for alopecia areata: A systematic review

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2Cp3Pey

Itching in a trichophytin contact dermatitis mouse model and the antipruritic effect of antifungal agents

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2M5rMHB

The Impact of Tobacco Cigarette Smoking on Spinal Cord Stimulation Effectiveness in Chronic Spine–Related Pain Patients

Background and Objectives Despite the observation that select nicotine receptor agonists have analgesic effects, smokers report higher pain scores and more functional impairments than lifelong nonsmokers, attributable to exaggerated stress responses, receptor desensitization, and altered pharmacokinetics compounded by accelerated structural damage resulting from impaired bone healing, osteoporosis, and advancement of disk disease. We hypothesized that smoking diminishes the analgesic response to spinal cord stimulation (SCS) in patients with chronic spine–related pain conditions. Methods A retrospective cohort study was performed at Cleveland Clinic by collecting and assessing data of 213 patients who had been implanted with SCS for spine-pain indications. History of tobacco smoking was subcategorized into 3 categories: past (former smoker), present (current smoker), or those who had never previously smoked (lifelong nonsmokers), and a multivariable linear regression was run to measure the correlation, if any, between smoking status and numerical rating scale pain score. In addition, opioid consumption at baseline and 12-month follow-up, expressed in milligram oral morphine equivalents, was collected and compared. Results Adjusted for differences, at 1-year follow-up, current smokers (n = 62) reported numerical rating scale pain score of 7.0, which is 1.93 (P

https://ift.tt/2wQYGXw

Sweet syndrome in association with enterobiasis

The Journal of Dermatology, EarlyView.


https://ift.tt/2Now8yc

Primary cicatricial alopecia in a single‐race Asian population: A 10‐year nationwide population‐based study in South Korea

The Journal of Dermatology, EarlyView.


https://ift.tt/2CF53mj

Clinical effectiveness of multi-wavelength photobiomodulation therapy as an adjunct to extracorporeal shock wave therapy in the management of plantar fasciitis: a randomized controlled trial

Abstract

The goal of our study was to investigate the cumulative effect of combining medium-energy extracorporeal shock wave therapy (ESWT) and photobiomodulation therapy (PBMT), as well as to compare between their relative effectiveness in the management of plantar fasciitis (PF). One hundred twenty participants with chronic PF, more than 6 months with failure to respond to conservative treatment, were randomly assigned into four equal groups. Participants received either ESWT with PBMT, ESWT (once a week), PBMT (three times a week), or sham-PBMT (three times a week) for three consecutive weeks. A home exercise program was also included for all four groups. Outcome measures included pressure pain threshold (PPT), visual analogue scale (VAS), and functional foot index disability subscale (FFI-d) that were collected prior to the first treatment session and at the end of the 3-week treatment period, as well as at a follow-up session, 12 weeks after the final treatment session. There were statistically significant improvements in post-intervention and follow-up PPT, VAS, and FFI-d values in all treatment groups (P < 0.0001). As for the sham-PBMT, no significant difference was found between the pre-, post-intervention and follow-up values (P > 0.05). Bonferroni correction test revealed that there was a significant difference between all the four groups in PPT, VAS, and FFI-d values (P < 0.0001). All active treatment groups maintained the treatment effect at the 12-week follow-up. Both ESWT and PBMT were effective in increasing PPT values, decreasing pain and increasing functional ability. Additionally, application of PBMT after ESWT was shown to be superior over ESWT and PBMT alone, and ESWT was superior over PBMT in terms of reducing pain sensitivity and increasing function.

Level of Evidence II.

https://ift.tt/2wQy1de

Evaluation the Efficacy of Hilotherm Cooling System in Reducing Postoperative Pain and Edema in Maxillofacial Traumatized Patients and Orthognathic Surgeries

Surgical treatment in patients with facial bone surgeries governs a meaningful extent of tissue trauma prompting prevalent postoperative portents of pain, facial swelling, and inconvenience. Beneficial effects of local cold therapy following surgery, facial swelling, pain, and inflammation have been discussed. The aim of study is to evaluate the efficacy of hilotherm cooling system in reducing postoperative pain and edema in patients following maxillofacial trauma and orthognathic surgeries. A clinical prospective study was done in the postoperative period for patients with facial trauma or those subjected to orthognathic surgery, 34 patients divided randomly into 2 groups; study group treated with the hilotherm cooling system and control group without. Facial swelling was quantified by 5 linear distances (A, B, C, D, and E). Pain was reported on day 1, 2, and 7 postoperatively. Satisfaction with cooling therapy at day 7 following surgery was recorded. The means of swelling variation in study group were less than in control group with highly significant difference (P  0.05). All patients in the study group were very satisfied. Address correspondence and reprint requests to Auday M. AL-Anee, BDS, FIBMS, Lecturer at Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Baghdad, and Oral and Maxillofacial Surgeon at Maxillofacial Surgery Department, Al-Shaheed Ghazi Al Hariri Teaching Hospital, Medical City, Bab-Almoadham, PO Box 1417, Baghdad, Iraq; E-mail: audayalanee@gmail.com Received 12 November, 2017 Accepted 17 July, 2018 The authors report no conflicts of interest. © 2018 by Mutaz B. Habal, MD.

https://ift.tt/2oP5dxC

Effect of Septoplasty on Cardiopulmonary Functions in the Patients With Nasal Obstruction

Objective: In this study, the authors aimed to investigate whether septoplasty has an effect on cardiopulmonary functions in the patients with nasal obstruction. Methods: A total of 53 patients with nasal obstruction due to septum deviation were included in the study. All the patients were performed septoplasty operation. Echocardiography and spirometric analysis were performed to assess cardiopulmonary functions before and after the operation (6 months postoperatively). The same evaluation was done for the degree of nasal obstruction by visual analogue scale. The preoperative and postoperative values were compared with each other. Results: Of the total 53 patients, 44 were males (83%) and 9 were female (17%). The mean age was 31.71 ± 9.46. The preoperative and postoperative mean right ventricular volumes were 2.0736 and 2.0906, respectively. The preoperative and postoperative mean left ventricular volumes were 4.4264 and 4.3528, respectively. The preoperative and postoperative mean cardiac septal thicknesses were 0.9642 and 0.9358, respectively. The mean value of preoperative cardiac posterior wall thicknesses was 0.8849, whereas the postoperative value was measured as 0.8340. The preoperative and postoperative mean pulmonary artery pressures were 27.8302 mmHg and 23.6415, respectively, and this was statistically significant (P 

https://ift.tt/2Cqd26g

Do Mandibular Third Molars Play a Role in Fractures of the Mandibular Angle and Condyle?

Introduction: The relationship between impacted mandibular third molars with angle and condylar fractures is subject of many publications, yet their conclusions differ widely, hence the authors wanted to investigate this topic in their patients. Methods: The authors designed a retrospective study including 241 patients who presented with angle and/or mandibular condyle fractures over a 13-year period at the authors' institution. The study variable was the presence/absence of third molars. The authors used the Pell and Gregory system to classify their position, whereas the angulation was classified using Archer classification. The outcome variables were the presence of angle and condylar fractures. Other study variables included fracture etiology. Results: Assaults were the most frequent cause of angle fractures (62.7%), whereas falls were mostly responsible for condylar fractures (79.6%). Angle fractures were mostly isolated (66.3%), whereas condylar fractures were mostly associated with other fractures (62.6%). The majority of the angle fractures occurred in patients with third molars (63.6%), on the contrary the majority of the condylar fractures occurred in patients without mandibular third molars (78.3%). Angle fractures were mostly associated with fully erupted or superficially impacted third molars (90,9%). Finally in the presence of mesioangulated third molars, condylar fractures did not happen in 83.8% of patients. Conclusions: According to the authors' findings, fully erupted or superficially impacted mandibular third molars are a risk factor for angle fractures but at the same time a protective factor for the condyle. On the contrary, the absence of mandibular third molars "strengthens" the angle and represents a risk factor for condylar fractures. Address correspondence and reprint requests to Shinnosuke Nogami, DDS, PhD, Division of Oral and Maxillofacial Surgery, Department of Oral Medicine, and Surgery, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Miyagi, Japan; E-mail: s-nogami@dent.tohoku.ac.jp, bnr32panda@yahoo.co.jp Received 26 January, 2018 Accepted 19 July, 2018 The authors performed this research with no financial support or incentive from any third party. The authors report no conflicts of interest. © 2018 by Mutaz B. Habal, MD.

https://ift.tt/2wUyCuB

Microvascular Replantation of the Avulsed Lip

Traumatic facial soft tissue injury often creates both aesthetic and functional deficits. In complete lip avulsions, microvascular replantation is a reconstructive option that has the potential to fulfill both of these goals. However, lip replantations remain rare and there are few reports in the literature. The authors aim to present a clinical report of a young male who sustained a human bite injury and underwent microvascular replantation of a completely avulsed lower lip and to review the literature and management of these complex injuries. Address correspondence and reprint requests to Mustafa Akyurek, MD, Division of Plastic Surgery, 55 Lake Avenue North, Worcester, MA 01655; E-mail: akyurekm@ummhc.org Received 1 February, 2018 Accepted 19 July, 2018 The authors report no conflicts of interest. © 2018 by Mutaz B. Habal, MD.

https://ift.tt/2CuL1uu

Ophthalmic Injuries Related to Maxillofacial Trauma Due to Urban Warfare

Midfacial trauma commonly causes ocular injuries of varying degrees. Eye injuries account for approximately 10% of all battle injuries. Severity of injuries may range from a subconjunctival haemorrhage to optic nerve injury and globe laceration and rupture. Aim of Study: Is to evaluate the associated ophthalmic injuries in maxillofacial trauma due to war and to emphasize the need for proper ophthalmic examination to exclude and manage any associated ophthalmic injuries. Materials and Methods: A total of 66 patients with maxillofacial trauma due to war were considered in this study and underwent classification of the fractures to know patterns of fractures and to specify the ophthalmic injuries which might be associated with each fracture. Referral to ophthalmologist was considered to determine the exact nature of ophthalmic injuries. Results by a maxillofacial surgeon and ophthalmologist were evaluated. Results: Midfacial trauma particularly those associated with zygomatic bone fracture was highly significant due to blast and bullets can lead to serious ophthalmic injuries. This was related to 57% of ophthalmic injuries. The related ocular injuries which were subconjunctival hemorrhage and the rupture or lacerated eye globe found to be highly significant war injuries while the preretinal hemorrhage and diplopia were significant. Conclusion: A thorough proper ophthalmic examination should be carried out for every patient with these fractures and suspected cases should be placed under close observation so that immediate and active treatment can be taken if necessary. Address correspondence and reprint requests to Akmam H. Al-Mahdi, FICMS, FDSRCS, Consultant Oral and Maxillofacial Surgeon, Chair of Arab Board Scientific Council of Maxillofacial Surgery in Iraq, Iraq-Baghdad-Medical City Hospital, POB 61123, Baghdad, Iraq; E mail: akmam65@yahoo.com Received 3 March, 2018 Accepted 19 July, 2018 The authors report no conflicts of interest. © 2018 by Mutaz B. Habal, MD.

https://ift.tt/2wRKjSR

Oculocardiac Reflex as a Late Presentation of Orbital Floor Fracture

Delayed repair of orbital trapdoor fractures can jeopardize the viability of entrapped contents and prolong recovery. Variation in presentations, both clinically and radiographically, complicate prompt diagnosis. The oculocardiac reflex may be the only indication of fracture with entrapped orbital contents, but, unfortunately, the reflex has variable onset patterns and can mimic common diagnoses. Therefore, the authors present the case of a 14-year-old male with a right orbital floor fracture, who presented with delayed symptoms secondary to an oculocardiac reflex. The vagal sequelae of the reflex, including gastric hyperactivity and headache, were experienced approximately 1 week after the injury and caused the patient to be misdiagnosed with gastroenteritis and status migrainosus, on 2 separate hospital visits. After admission to the hospital due to progressive symptoms, a CT scan showed concerns for a subacute orbital blowout fracture. The patient underwent orbital floor exploration with findings of scarred orbital fat herniating into a healing fracture site. Repositioning of the fat into the orbit resulted in immediate resolution of the patient's symptoms. Awareness of the presenting characteristics of the oculocardiac reflex can lead to prompt diagnosis and maximize clinical outcomes. Address correspondence and reprint requests to Renata S. Maricevich, MD, 6701 Fannin St, CC 610.00, Houston, TX 77030; E-mail: Renata.Maricevich@bcm.edu Received 5 June, 2018 Accepted 20 July, 2018 The authors report no conflicts of interest. © 2018 by Mutaz B. Habal, MD.

https://ift.tt/2CtKn0h

Porous Polyethylene Implant Associated With Delayed Orbital Complications and Osteomyelitis After Orbital Reconstruction

Orbital implants are commonly used to repair orbital blowout fractures, to restore the functional and anatomical structure of the orbit. Porous polyethylene implants are a type of alloplastic implant and are widely used for orbital reconstruction as micropores facilitate the growth of fibers and blood vessels through the material. Rare complications associated with porous polyethylene implants used to treat blowout fractures include delayed orbital inflammation and osteomyelitis. The authors describe a 68-year-old man who presented with a 5-year delayed porous polyethylene implant infection and cicatricial ectropion with osteomyelitis after an orbital blowout fracture repair. The patient underwent surgery to incision and drainage of orbital abscess with ectropion correction surgery. He was treated with intravenous antibiotics for 6 weeks due to osteomyelitis and made a good recovery. Address correspondence and reprint requests to Jung Hyo Ahn, MD, Department of Ophthalmology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20 Geumo-ro, Mulgum, Yangsan, Gyeongnam 50612, South Korea; E-mail: jhahn77@daum.net Received 25 May, 2018 Accepted 27 July, 2018 The authors report no conflicts of interest. © 2018 by Mutaz B. Habal, MD.

https://ift.tt/2wQLcuZ

Epineurial Nerve Coaptation: A Biological Nonliving Training Model Using Gradually Thawed Cryopreserved Sciatic Nerves

The authors present a novel biological nonliving epineurial nerve coaptation training model, which allows cost-efficient practicing on organic mammal nerves and offers an objective performance control on the basis of successful suturing and respecting the 3R model. Anatomic dissection of 40 rat cadavers was performed. Four residents without prior microneurosurgical experience were included. Each trainee performed 20 epineurial nerve coaptations. The number of successful sutures served as qualitative variable and operation time as a quantitative variable for efficiency control. The rate for successful sutures was 51.9% in the first half of trials and improved to 94.4% in the second half. Whereas, the trainees needed a mean time of 34 minutes for the first 10 coaptations, the last 10 coaptations were performed within 24.5 minutes. The authors' presented model is an easily accessible, low-cost microneurosurgical simulation model, allowing a realistic and instructive performance of epineurial nerve coaptation. Because cadaveric nerves are used, an approval of the local ethics committee is not needed. Furthermore, anatomic knowledge about the topography related to the harvest of the sciatic nerve of rats is provided in this study. Address correspondence and reprint requests to Dr Ali-Farid Safi, MD, DMD, Kerpener Straße 62, 50937 Cologne, Germany; E-mail: asafi@outlook.de Received 26 June, 2018 Accepted 19 July, 2018 The authors report no conflicts of interest. © 2018 by Mutaz B. Habal, MD.

https://ift.tt/2CF31CH

The Boomerang Epicanthoplasty: A Technique That Avoids Hooding

Redraping is an increasingly common epicanthoplasty method. However, hooding usually remains at the medial part of the upper eyelid. The authors innovated a modification of redraping epicanthoplasty using excision, resulting in a boomerang-shaped defect that does not lead to hooding of the medial upper eyelid. Medial line (M-line) was drawn at the most medial point of the palpebral fissure. The canthus point (C-point) was marked approximately 1 to 3 mm laterally from the M-point, depending on the amount of widening needed. From the C-point, upper incision was designed to meet the double eyelid line. A V-shaped lower incision was designed 3 to 4 mm below the ciliary margin. A flap was elevated about 7 mm superiorly, 10 mm medially, and 5 mm inferiorly. The elevated skin flap was redraped and the M'-point, which reflected the M-point on the redraped skin, was marked. A curvilinear incision line reflecting previous incision lines was drawn. The crescent-shaped excess skin was excised and the medial canthus was retracted medially, and then the boomerang-shaped defect was observed. The M-point and M'-point were coapted with a suture. The dog-ear at the lower side was trimmed. The 525 patients were followed up for ≥3 months postoperatively. The average increase in the palpebral fissure length was 1.2 ± 0.5 mm. The average decrease in the interepicanthal distance was 2.4 ± 0.9 mm. The average satisfaction score was 4.6 ± 0.6. Boomerang epicanthoplasty can prevent hooding on the medial aspect of the upper eyelid. It is easy to design, requires marking only 1 point, and is tension-free, thereby reducing scar widening. Address correspondence and reprint requests to Kun Hwang, MD, PhD, Department of Plastic Surgery, Inha University School of Medicine, 27 Inhang-ro, Jung-gu, Incheon 22332, Korea; E-mail: jokerhg@inha.ac.kr Received 4 April, 2018 Accepted 6 August, 2018 This study was supported by a grant from National Research Foundation of Korea (NRF-2017R1A2B4005787). The authors report no conflicts of interest. © 2018 by Mutaz B. Habal, MD.

https://ift.tt/2oKQ6oC

Respiratory Pathway and Swallowing Management in a Patient With Epiglottis Loss After Life-Threatening Penetrating Laryngeal Trauma

Laryngeal trauma is a rare but potentially life-threatening injury. Damage to larynx structures may occur in forms of a simple contusion, fractures of the laryngeal cartilage, and may even result in laryngotracheal disjunction depending on the ossification level of the larynx and the severity of the trauma. However, in almost all cases, damaged laryngeal tissue is also observed in the trauma area. Because thyroid cartilage protects the endolaryngeal tissues like a shield against trauma. Epiglottis prevents escape of the food to respiratory tract and directs food to digestive system. In this article, a case of knife attack resulted in deep neck incision with loss of epiglottis in the incision area, the surgical operation, and the postoperative recovery period which had a clinical significance due to loss of epiglottis were presented. To the best of our knowledge, this is the first laryngeal trauma case with loss of epiglottis. Address correspondence and reprint requests to Suha Ertugrul, Sirinevler mahallesi, Alpaslan caddesi, no: 1, Merkez, Karabuk 78200, Turkey; E-mail: drsuhaertugrul@hotmail.com Received 14 July, 2018 Accepted 6 August, 2018 The authors report no conflicts of interest. © 2018 by Mutaz B. Habal, MD.

https://ift.tt/2CuC0BG

Intraoral Anastomosis of Deep Circumflex Iliac Artery Perforator Flap for Maxillary Reconstruction

Maxillary reconstruction is one of the most challenging areas of reconstructive surgery. This report describes a case of a 33-year-old male with osteoblastic osteosarcoma of the maxillary. The patient received radical resection and reconstruction with a deep circumflex iliac artery perforator flap (DCIAPF). The flap was harvested with a 4 × 2 cm2 osseous flap and a 6 × 8 cm2 skin island supplied by terminal perforators from the deep circumflex iliac artery. Anastomosis was accomplished on the ipsilateral facial vessels with deep circumflex iliac vessels through an intraoral approach. The donor site and the flap were observed to have completed primary healing 2 weeks after the surgery. The DCIAPF may be a satisfactory single-flap option for maxillary reconstruction with less donor-site complications. Address correspondence and reprint requests to Lei Zheng, MD, Department of Oral and Maxillofacial Surgery, 22# Zhongguancun South Avenue, Peking University School and Hospital of Stomatology, Beijing 100081, China; E-mail: zhenglei2bh@163.com Received 10 May, 2018 Accepted 12 July, 2018 This study was supported by Program for New Clinical Techniques and Therapies of Peking University School and Hospital of Stomatology (Number: PKUSSNCT-16A02). The authors report no conflicts of interest. © 2018 by Mutaz B. Habal, MD.

https://ift.tt/2wQWuzg

Addition of oral mini pulse dexamethasone to NBUVB phototherapy and topical steroids helps arrest disease activity in patients with vitiligo

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2M35d6g

“GENIPSO”: a French prospective study assessing instantaneous prevalence, clinical features and impact on quality of life of genital psoriasis among patients consulting for psoriasis

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MVEWMj

Local interventions for actinic keratosis in organ transplant recipients: A systematic review

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2wQYg2C

Benefit‐risk of tofacitinib in patients with moderate to severe chronic plaque psoriasis: Pooled analysis across 6 clinical trials

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MVEVYL

A new clinical variant of acquired reactive perforating dermatosis‐like bullous pemphigoid

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2wPZkUh