Increased Incidence of Tapia's Syndrome Cases Since the COVID-19 Pandemic

xlomafota13 shared this article with you from Inoreader Increased Incidence of Tapia's Syndrome Cases Since the COVID-19 Pandemic Via ear nose throat Ear Nose Throat J. 2021 Dec 30:1455613211068570. doi: 10.1177/01455613211068570. Online ahead of print. NO ABSTRACT PMID:34969313 | DOI:10.1177/01455613211068570 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Administrative delays of temporary recommendation for use: Impact on access to innovation in melanoma

xlomafota13 shared this article with you from Inoreader Administrative delays of temporary recommendation for use: Impact on access to innovation in melanoma Via Association française pour l'étude du cancer Bull Cancer. 2021 Dec 28:S0007-4551(21)00514-2. doi: 10.1016/j.bulcan.2021.11.007. Online ahead of print. ABSTRACT INTRODUCTION: Melanoma has benefited in recent years from therapeutic innovations, which have improved overall survival of patients. France has developed a regulatory arsenal allowing faster access to innovative drugs before marketing authorization: temporary authorization for use (ATU) and temporary recommendation for use (RTU). METHOD: We describe here the decision-making processes that led to the non-publication of the decree on the funding of three RTU in adjuvant melanoma therapy: nivolumab, pembrolizumab and the combination of dabrafenib and trametinib, and we analyse the fate of these drugs in order to quantify the potential loss of chance. RESULTS: On 03AUG2018, the French National Agency for Medicines and Health Product Safety (ANSM) published 3 RTU in order to give rapid access to major innovations in adjuvant melanoma therapy: nivolumab, pembrolizumab and the combination of dabrafenib and trametinib. These drugs have respectively demonstrated reductions in the risk of recurrence by 35 %, 43% and 55% for target populations of 2200, 1900 and 650 patients per year. Despite a favourable opinion on reimbursement from the French National Authority for Health (HAS), the decrees on reimbursement will never be published, prohibiting the use of these products before the marketing authorisation, and depriving many patients of a potential cure. CONCLUSION: Despite a favourable opinion from scientists and health agencies for the rapid availability of a drug, the French public health code does not systematically imply access to a therapeutic innovation. The reform of access to innovation implemented on 01JUL2021 may help tackle this issue. PMID:34972538 | DOI:10.1016/j.bulcan.2021.11.007 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Restoration of Homeostasis in the Tracheal Mucosa After Thyroid Surgery in a Rat Model

xlomafota13 shared this article with you from Inoreader Restoration of Homeostasis in the Tracheal Mucosa After Thyroid Surgery in a Rat Model Via In vivo (Athens, Greece) In Vivo. 2022 Jan-Feb;36(1):161-169. doi: 10.21873/invivo.12687. ABSTRACT BACKGROUND/AIM: This study aimed to investigate the process of homeostatic restoration in the tracheal mucosa (TM) after thyroid surgery. MATERIALS AND METHODS: Fifty-four rats were divided into normal controls (NC) and three experimental groups: (i) flap elevation (FE), (ii) thyroid exposure (TE), and (iii) thyroid isthmusectomy (TI). Expression of mRNA and proteins of key factors regulating homeostasis were evaluated in the TM obtained 3, 7, and 21 days after thyroid surgery. RESULTS: Increased mRNA expression of transforming growth factor-β1 (TGF-β1), hypoxia-inducible factor-1α (HIF-1α), and matrix metalloproteinase-9 (MMP-9) were observed 21 days after thyroid surgery in all experimental groups compared to that of NC group. CONCLUSION: Thyroid surgery leads to an actual increase of TGF-β1, HIF-1α, and MMP-9 expression in the TM. This increased expression of key regulators of homeostatic restoration in the TM lasts for a considerable period of time after surgery, especially if the extent of surgery increased. PMID:34972711 | DOI:10.21873/invivo.12687 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Prone Positioning in Patients With COVID-19: Analysis of Multicenter Registry Data and Meta-analysis of Aggregate Data

xlomafota13 shared this article with you from Inoreader Prone Positioning in Patients With COVID-19: Analysis of Multicenter Registry Data and Meta-analysis of Aggregate Data Via In vivo (Athens, Greece) In Vivo. 2022 Jan-Feb;36(1):361-370. doi: 10.21873/invivo.12711. ABSTRACT BACKGROUND/AIM: Evidence suggests a beneficial effect of prone positioning (PP) in COVID-19. MATERIALS AND METHODS: Meta-analysis of individual (7 investigators' groups) and aggregate data (PubMed/EMBASE) regarding the impact of PP on the ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PO2/FiO2) in patients with COVID-19. RESULTS: Among 121 patients (mean age±SD 59.1±10.7 years, 55% males, 57% intubated) the mean post-versus pre- PP PO2/FiO2 difference was: (i) 50.4±64.3 mmHg, p<0.01, (ii) similar in awake (58.7±72.1 mmHg) versus intubated patients (44.1±57.5 mmHg, p=NS), (iii) inversely correlated with body mass index (r=-0.43, p<0.01). Meta-analysis of 23 studies (n=547, weighted age 58.3±4.1, 73% males, 59% intubated) showed a pooled PO2/FiO2 difference of 61.8 [95% confidence intervals=49.9-73.6] mmHg. Meta-regression analysis revealed no associations with baseline demographics, the time in PP before assessment, and the risk of bias of the studies. CONCLUSION: PP seems to improve oxygenation of patients with COVID-19. PMID:34972735 | DOI:10.21873/invivo.12711 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Impact of Pectoral Muscle Values on Clinical Outcomes in Patients With Severe Covid-19 Disease

xlomafota13 shared this article with you from Inoreader Impact of Pectoral Muscle Values on Clinical Outcomes in Patients With Severe Covid-19 Disease Via In vivo (Athens, Greece) In Vivo. 2022 Jan-Feb;36(1):375-380. doi: 10.21873/invivo.12713. ABSTRACT BACKGROUND/AIM: The effect of sarcopenia on patients with severe Covid-19 disease is unknown. We aimed to assess the influence of baseline computed tomography (CT)-based body composition parameters (pectoralis muscle area, pectoralis muscle index, skeletal muscle gauge) on clinical variables in patients with severe Covid-19 disease. PATIENTS AND METHODS: Chest CT scans of adult patients with confirmed Covid-19 who were hospitalized from March 2020 to May 2021 at a level-one medical center in Germany were retrospectively analyzed. Pectoralis muscle area, pectoralis muscle index and skeletal muscle gauge were measured on the first CT scan after admission. Body composition parameters were assessed for association with clinical variables and 30-day mortality. RESULTS: A total of 46 patients were included. None of the body composition parameters was a pred ictor for 30-day mortality, duration of hospital stay, duration of intensive care unit treatment, or duration of invasive mechanical ventilation. CONCLUSION: Pectoralis muscle composition parameters in CT chest scans did not predict outcomes in adult patients with severe Covid-19 infection. PMID:34972737 | DOI:10.21873/invivo.12713 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Surgical Techniques of Y-Sleeve Lobectomy in Patients With Primary Lung Cancer

xlomafota13 shared this article with you from Inoreader Surgical Techniques of Y-Sleeve Lobectomy in Patients With Primary Lung Cancer Via In vivo (Athens, Greece) In Vivo. 2022 Jan-Feb;36(1):350-354. doi: 10.21873/invivo.12709. ABSTRACT BACKGROUND/AIM: The directions of distal and proximal airway stumps were different in Y-sleeve lobectomy. This difference might make Y-sleeve lobectomy a difficult procedure. In this article, we present our surgical techniques and analyse short-term outcomes of Y-sleeve lobectomy. PATIENTS AND METHODS: Right middle and lower, left lower, and left lower and lingular segment sleeve lobectomies are categorized in Y-sleeve lobectomy. We retrospectively investigated the clinical courses of 17 patients who underwent Y-sleeve lobectomy from January 2017 to December 2020. RESULTS: No treatment-related deaths occurred. One patient developed a bronchopleural fistula. Four patients developed pneumonia and were cured by repeated bronchoscopies and antibiotic therapy. Three patients had retention of pleural effusion, and two had prolonged air leakage. One patient had empyema after prolonged air leakage and was cured by thoracic drainage and antibiotic therapy. CONCLUSION: A major complication was observed only in one patient. Y-sleeve lobectomy is a reliable surgical method to avoid pneumonectomy. PMID:34972733 | DOI:10.21873/invivo.12709 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Vesico-uterine Fistula Following C-section - A Case Report and Literature Review

xlomafota13 shared this article with you from Inoreader Vesico-uterine Fistula Following C-section - A Case Report and Literature Review Via In vivo (Athens, Greece) In Vivo. 2022 Jan-Feb;36(1):528-532. doi: 10.21873/invivo.12734. ABSTRACT BACKGROUND/AIM: Vesico-uterine fistulas represent a rare type of genito-urinary fistulas; however, due to the increasing incidence of Caesarean section (C-section) in the last decade, this abnormal communication between the urinary and genital tracts has been reported more often after such surgical procedures. The aim of the current article was to report the case of a 28-year-old patient who was submitted to surgery for a vesico-uterine fistula seven years after a C-section. CASE REPORT: The 28-year-old patient with a previous history of four vaginal deliveries and one C-section was self-presented to the Gynecology Department for cyclic hematuria and diagnosed with a vesico-uterine fistula after injecting methylene blue in the uterine cavity during hysteroscopy. The patient was further submitted to surgery, and a parcelar myometrectomy en bloc with parcelar cystectomy, cystography, and prophylactic salpingectomy was performed. The postoperative outcome was uneventful. CONCLUSION: Although vesico-uterine fistulas represent rare events, they should be considered, especially in young patients with a previous history of C-section. PMID:34972758 | DOI:10.21873/invivo.12734 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

VsN, a Reliability-index of Shear-wave Measurement in Sonoelastography, Is Useful for the Diagnosis of Thyroid Tumor Malignancy

xlomafota13 shared this article with you from Inoreader VsN, a Reliability-index of Shear-wave Measurement in Sonoelastography, Is Useful for the Diagnosis of Thyroid Tumor Malignancy Via In vivo (Athens, Greece) In Vivo. 2022 Jan-Feb;36(1):264-273. doi: 10.21873/invivo.12700. ABSTRACT BACKGROUND/AIM: Shear wave measurement (SWM) is a new elastography modality that quantifies the shear wave velocity (Vs) and the percentage of the net effective shear wave velocity (VsN). This study examined whether these parameters could be used to differentiate between malignant and benign thyroid tumors. PATIENTS AND METHODS: The study of SWM enrolled 111 patients (133 nodules) who underwent thyroid surgery. Overall, 61 nodules were diagnosed as benign and 72 as malignant, of which 68 nodules were diagnosed as papillary thyroid carcinoma (PTC) and 4 as follicular thyroid carcinoma (FTC). RESULTS: A preoperative SWM revealed that Vs was significantly higher and VsN significantly lower in the PTC compared to the benign nodules. The VsN of FTC was significantly lower than that of follicular adenoma. Multivariate analysis revealed that VsN significantl y correlated with nodule malignancy. CONCLUSION: SWM parameters, especially VsN, can potentially differentiate between benign and malignant thyroid nodules non-invasively. PMID:34972724 | DOI:10.21873/invivo.12700 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Sternocleidomastoid Muscle Transfer for Treatment of Longstanding Facial Paralysis: Long-term Outcomes and Complications

xlomafota13 shared this article with you from Inoreader Sternocleidomastoid Muscle Transfer for Treatment of Longstanding Facial Paralysis: Long-term Outcomes and Complications Via In vivo (Athens, Greece) In Vivo. 2022 Jan-Feb;36(1):501-509. doi: 10.21873/invivo.12731. ABSTRACT BACKGROUND/AIM: The use of sternocleidomastoid muscle (SCM) flap for facial reanimation was established in the 1980s by the senior author of this paper. We aimed to analyze long-term outcome and complications of this procedure. PATIENTS AND METHODS: We conducted a retrospective chart review of all patients undergoing SCM reanimation for longstanding facial palsy between January 2009 and December 2015. Patients with follow-up longer than 12 months (range=12-96) were included in the study. Facial muscle function was evaluated before and at each follow-up after the surgery with the House-Brackmann (HB) scale-facial nerve grading system and Facegram analysis. Donor site morbidity and overall complication rates were documented and analyzed. RESULTS: Forty-two patients aged 18-66 years (mean age=37) with a mean duration of facial palsy of 5 years (range=2-4 8) met the inclusion criteria. The HB score 2 years after surgery improved significantly (p<0.05) in comparison to the pre-operative condition (3.6 vs. 4.7). Twelve months after surgery, oral commissure excursion improved by mean 8.95 mm. No flap necrosis occurred, nor compromise of neck and shoulder function despite an obvious contour defect in the SCM donor site. None of the patients presented head posture or movement issues. CONCLUSION: The SCM flap transfer is a reliable and effective procedure to achieve moderate improvement of the oral commissure excursion using a local method with moderate donor site morbidity. It can be regarded as a valuable option for dynamic facial reanimation in case of longstanding facial palsy. PMID:34972755 | DOI:10.21873/invivo.12731 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Colonic Metastasis from Breast Cancer: A Case Report and Review of the Literature

xlomafota13 shared this article with you from Inoreader Colonic Metastasis from Breast Cancer: A Case Report and Review of the Literature Via In vivo (Athens, Greece) In Vivo. 2022 Jan-Feb;36(1):522-527. doi: 10.21873/invivo.12733. ABSTRACT BACKGROUND: Breast cancer often metastasizes to the lungs, bones, liver, and brain, colon metastasis from breast cancer (CMBC) is extremely rare. CASE REPORT: The patient was a 63-year-old female. Mastectomy had been performed for breast cancer (pStage IIB) 15 years earlier at another hospital. Metastasis to the lumbar spine had been detected 4 years prior to referral to us and the patient had undergone hormonal therapy with an aromatase inhibitor. Furthermore, early primary sigmoid colon cancer had been endoscopically resected 2 years before referral. The patient was diagnosed with cancer recurrence in the colon at follow-up examinations performed 2 years after that endoscopic resection. After referral to our hospital, laparoscopic sigmoidectomy was performed. Based on the histopathological examination and immunohistological staining results (positive for cytokeratin 7, GATA-binding protein 3, estrogen receptor and human epidermal growth factor receptor-related 2 (2+); negative for cytokeratin 20, progesterone receptor, E-cadherin, gross cystic disease fluid protein 15 and caudal-related homeobox 2) the final pathological diagnosis was CMBC. CONCLUSION: Although extremely rare, the possibility of CMBC should be considered in the case of colonic tumors in patients with a history of breast cancer. PMID:34972757 | DOI:10.21873/invivo.12733 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Framework for Indirect Spatial Calibration of the Horizontal Plane of Endoscopic Laryngeal Images

xlomafota13 shared this article with you from Inoreader Framework for Indirect Spatial Calibration of the Horizontal Plane of Endoscopic Laryngeal Images Via Journal of Voice Calibrated horizontal-plane measurements from laryngeal images could contribute significantly to refining evidence-based practice and developing patient-specific models and precision-medicine approaches. Laser-projection endoscopes can address the need for direct calibrated measures; however, these systems are not widely available. This study presents the framework for an alternative indirect horizontal-plane calibration approach. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.