Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy
Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy via ScienceDirect Publication: European Journal of Cancer Publication date: Available online 13 April 2016 *Source:*European Journal of Cancer Author(s): Lars Hofmann, Andrea Forschner, Carmen Loquai, Simone M. Goldinger, Lisa Zimmer, Selma Ugurel, Maria I. Schmidgen, Ralf Gutzmer, Jochen S. Utikal, Daniela Göppner, Jessica C. Hassel, Friedegund Meier, Julia K. Tietze, Ioannis Thomas, Carsten Weishaupt, Martin Leverkus, Renate Wahl, Ursula Dietrich, Claus Garbe, Michael C. Kirchberger, Thomas ...περισσότερα »
Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy
Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy via ScienceDirect Publication: European Journal of Cancer Publication date: Available online 13 April 2016 *Source:*European Journal of Cancer Author(s): Lisa Zimmer, Simone M. Goldinger, Lars Hofmann, Carmen Loquai, Selma Ugurel, Ioannis Thomas, Maria I. Schmidgen, Ralf Gutzmer, Jochen S. Utikal, Daniela Göppner, Jessica C. Hassel, Friedegund Meier, Julia K. Tietze, Andrea Forschner, Carsten Weishaupt, Martin Leverkus, Renate Wahl, Ursula Dietrich, Claus Garbe, Michael C. Kirchberger, Thom... περισσότερα »
Toenail selenium status and risk of subtypes of head-neck cancer
: The Netherlands Cohort Study via ScienceDirect Publication: European Journal of Cancer Publication date: June 2016 *Source:*European Journal of Cancer, Volume 60 Author(s): Denise H.E. Maasland, Leo J. Schouten, Bernd Kremer, Piet A. van den Brandt BackgroundThere is limited prospective data on the relationship between selenium status and the risk of head-neck cancer (HNC) and HNC subtypes (i.e., oral cavity cancer [OCC], oro-/hypopharyngeal cancer [OHPC] and laryngeal cancer [LC]). Therefore, we investigated the association between toenail selenium, reflecting long-term selenium exp... περισσότερα »
PEDF Loss in Cancer-Associated Fibroblasts
Loss of pigment epithelium-derived factor (PEDF, SERPINF1) in cancer cells is associated with poor prognosis and metastasis, but the contribution of stromal PEDF to cancer evolution is poorly understood. Therefore, we investigated the role of fibroblast-derived PEDF in melanoma progression. We demonstrate that normal dermal fibroblasts expressing high PEDF levels attenuated melanoma growth and angiogenesis in vivo, whereas PEDF-depleted fibroblasts exerted tumor-promoting effects. Accordingly, mice with global PEDF knockout were more susceptible to melanoma metastasis. We also dem... περισσότερα »
Ibrutinib Impairs MDSC Generation and Function
Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immature myeloid cells that expand in tumor-bearing hosts in response to soluble factors produced by tumor and stromal cells. MDSC expansion has been linked to loss of immune effector cell function and reduced efficacy of immune-based cancer therapies, highlighting the MDSC population as an attractive therapeutic target. Ibrutinib, an irreversible inhibitor of Bruton's tyrosine kinase (BTK) and IL2-inducible T-cell kinase (ITK), is in clinical use for the treatment of B-cell malignancies. Here, we report that BTK... περισσότερα »
MCAM and LAMA4 Are Vascular Targets in Renal Cancer
The structure and molecular signature of tumor-associated vasculature are distinct from those of the host tissue, offering an opportunity to selectively target the tumor blood vessels. To identify tumor-specific endothelial markers, we performed a microarray on tumor-associated and nonmalignant endothelium collected from patients with renal cell carcinoma (RCC), colorectal carcinoma, or colorectal liver metastasis. We identified a panel of genes consistently upregulated by tumor blood vessels, of which melanoma cell adhesion molecule (MCAM) and its extracellular matrix interaction... περισσότερα »
C GAMP, Where Is Thy STING?
Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are required for the function of STING (TMEM173), an ER-resident transmembrane protein critical for cytoplasmic DNA sensing, IFN production, and cancer control. Here we show that the IRE-1/XBP-1 pathway functions downstream of STING and that STING agonists selectively trigger mitochondria-mediated apoptosis in normal and malignant B cells. Upon stimulation, STING was degraded less efficiently in B cells, implying that prolonged activation of STING can lead to apoptosis. Transient activation of the IRE-1/XB... περισσότερα »
MTH1, Redox Environment, and Hypoxia Signaling
Cancer cells are commonly in a state of redox imbalance that drives their growth and survival. To compensate for oxidative stress induced by the tumor redox environment, cancer cells upregulate specific nononcogenic addiction enzymes, such as MTH1 (NUDT1), which detoxifies oxidized nucleotides. Here, we show that increasing oxidative stress in nonmalignant cells induced their sensitization to the effects of MTH1 inhibition, whereas decreasing oxidative pressure in cancer cells protected against inhibition. Furthermore, we purified zebrafish MTH1 and solved the crystal structure of... περισσότερα »
Tissue and Tumor NK Cell Alterations in Prostate Cancer
The field of immunotherapy for solid tumors, such as prostate cancer, has been recently focusing on therapies that can counter tumor-mediated immunosuppression. Precise quantification and characterization of the immune infiltrates in tumors is crucial to improve treatment efficacy. Natural killer (NK) cells, major components of the antitumor immune system, have never been isolated from prostate tumors, despite their suspected role in disease progression. Here, we examined the frequency, phenotype, and functions of NK cells infiltrating control and tumor prostate tissues. NK cell i... περισσότερα »
Selected Articles from This Issue
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
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Inhibition of PI3K{alpha} Radiosensitizes Head and Neck Tumors
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Purpose: Activating PIK3CA genomic alterations are frequent in head and neck squamous cell carcinoma (HNSCC), and there is an association between phosphoinositide 3-kinase (PI3K) signaling and radioresistance. Hence, we investigated the therapeutic efficacy of inhibiting PI3K with GDC-0032, a PI3K inhibitor with potent activity against p110α, in combination with radiation in HNSCC. Experimental Design: The […]
NK Cell-Based Cancer Immunotherapy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
The article by Curti and colleagues highlights the potential of natural killer (NK) cell–based adoptive cellular immunotherapy in oncology, currently boosted by advances in the knowledge on NK cell biology and in their ex vivo GMP manipulation. Several issues deserve attention to fully achieve the translation of these advances to the clinic. Clin Cancer Res; […]
PD-L1 Is Highly Expressed in Primary Prostate Cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Purpose: Therapies targeting the programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway promote anti-tumor immunity and have shown promising results in various tumors. Preliminary data further indicate that immunohistochemically detected PD-L1 may be predictive for anti-PD-1 therapy. So far, no data are available on PD-L1 expression in primary prostate cancer. Experimental Design: Following validation […]
Nelfinavir as a Clinical Radiosensitizer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Repurposing agents approved for other indications to radiosensitize tumors may be advantageous. The study by Hill and colleagues utilizes nelfinavir, an HIV protease inhibitor (PI), in combination with radiotherapy in rectal cancer in a prospective study. This combination may improve tumor perfusion and regression compared with radiotherapy alone. Clin Cancer Res; 22(8); 1834–6. ©2016 AACR. […]
CML LSCs Express CD25
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Purpose: In chronic myelogenous leukemia (CML), leukemic stem cells (LSC) represent a critical target of therapy. However, little is known about markers and targets expressed by LSCs. The aim of this project was to identify novel relevant markers of CML LSCs. Experimental Design: CML LSCs were examined by flow cytometry, qPCR, and various bioassays. In […]
Isocitrate Dehydrogenase Mutations in Cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to α-ketoglutarate (α-KG) and concomitantly produce reduced NADPH from NADP+. Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma. The mutant protein loses […]
Gemtuzumab Ozogamicin in Pediatric FLT3/ITD AML Patients
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Purpose: Gemtuzumab ozogamicin (GO), a calicheamicin-conjugated mAb against CD33, has been used in the treatment of acute myeloid leukemia (AML). We evaluated the impact of the addition of GO to standard chemotherapy and hematopoietic stem cell transplant (HCT) in patients with FLT3/ITD. Experimental Design: We analyzed children with FLT3/ITD–positive AML (n = 183) treated on […]
Disruptive Immunology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
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Hepatitis C ups risk of head, neck cancers – ETHealthWorld.com
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
ETHealthWorld.com Hepatitis C ups risk of head, neck cancers ETHealthWorld.com Also paramount to the research, said Torres, was to control for smoking, a major risk factor for head and neck cancers. Therefore, they identified 694 control subjects, all with a diagnosis of smoking-related cancers (378 with lung, 168 with esophageal … from #AlexandrosSfakianakis via Alexandros […]
Anti-PD1 therapy
Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy via ScienceDirect Publication: European Journal of Cancer Publication date: Available online 13 April 2016 *Source:*European Journal of Cancer Author(s): Lars Hofmann, Andrea Forschner, Carmen Loquai, Simone M. Goldinger, Lisa Zimmer, Selma Ugurel, Maria I. Schmidgen, Ralf Gutzmer, Jochen S. Utikal, Daniela Göppner, Jessica C. Hassel, Friedegund Meier, Julia K. Tietze, Ioannis Thomas, Carsten Weishaupt, Martin Leverkus, Renate Wahl, Ursula Dietrich, Claus Garbe, Michael C. Kirchberger, Thomas ...περισσότερα »
Prognostic effect of symptomatic extracranial lesions on survival of recursive partitioning analysis Class III brain metastatic patients treated with stereotactic radiotherapy
Prognostic effect of symptomatic extracranial lesions on survival of recursive partitioning analysis Class III brain metastatic patients treated with stereotactic radiotherapy: *Xiu-Jun Chen, Jian-Ping Xiao, Xiang-Pan Li, Xue-Song Jiang, Ye Zhang* Journal of Cancer Research and Therapeutics 2016 12(1):215-220 Objective: To explore the outcome and prognostic factors of recursive partitioning analysis (RPA) Class III brain metastatic patients treated with stereotactic radiotherapy (SRT). Materials and Methods: Fifty-six consecutive patients with metastatic brain tumors and Karnof... περισσότερα »
Nasopharyngeal carcinoma with headaches as the main symptom
A potential diagnostic pitfall: *Zhou-Xue Wu, Li Xiang, Jin-Feng Rong, Huai-Lin He, Dan Li* Journal of Cancer Research and Therapeutics 2016 12(1):209-214 Background: The aim of this study was to investigate medical-related reasons for misdiagnosis of nasopharyngeal carcinoma. (NPC) patients presenting with headaches alone or accompanied by other symptoms. Patients and Methods: Two-hundred and nineteen NPC cases describing headaches as one of the initial symptoms during primary treatment were selected for this prospective study. Medical records were carefully collected and all ... περισσότερα »
Oral verrucous carcinoma
A retrospective analysis for clinicopathologic features: *Wanjari G Sonalika, Tegginamani Anand* Journal of Cancer Research and Therapeutics 2016 12(1):142-145 Aim: To study the clinicopathological features of oral verrucous carcinoma (VC). Methods: Archives of the department were retrieved for verrucous lesions. After thorough histopathologic examination, 10 cases were confirmed as VC. Age, sex, site, tobacco habit, clinical presentation, and histologically, the presence of dysplasia and koilocytic changes were studied. Results: Oral VC showed a distinct male preponderance wi... περισσότερα »
Oral submucous fibrosis and ABO blood grouping
Is there an association between oral submucous fibrosis and ABO blood grouping?: *Venu K Gopal Reddy, Ninad J Moon, Vijayta Sharva, Guruprasad , Eshwar K Reddy, Sujitha Chandralkala* Journal of Cancer Research and Therapeutics 2016 12(1):126-130 Background: Oral submucous fibrosis (OSMF) is one of the most common premalignant conditions in Indian subcontinent due to the traditional use of Areca nut and its various preparations. The genetic predisposition has also been reported in its etiopathogenesis. The rate of malignant transformation is between 7% to 14%. Aim: To evaluate w...περισσότερα »
Quantitative analysis of agnor counts of buccal mucosal cells of chewers and non chewers of gutkha: A comparative cytologic study
Quantitative analysis of agnor counts of buccal mucosal cells of chewers and non chewers of gutkha: A comparative cytologic study: *Nikhil I Malgaonkar, Kapil Dagrus, Srinivas S Vanaki, Rudrayya S Puranik, Manjunatha Bhari Sharanesha, Bassel Tarakji* Journal of Cancer Research and Therapeutics 2016 12(1):228-231 Aims and Objectives: The present study was taken up to evaluate the AgNOR counts in the buccal mucosa cells of gutkha chewers and compare that with the sex-matched controls. Materials and Methods: In all, 100 gutkha chewers and 50 sex-matched non-chewers (controls) were...περισσότερα »
Cost-effectiveness of implant-supported mandibular removable partial dentures
[image: cover.gif?v=1&s=ea3ed681cef4af2a1760b136] Abstract Objectives The aim of this study was to conduct a cost-effectiveness analysis comparing conventional removable partial dentures (RPDs) and implant-supported RPDs (ISRPDs) treatment in patients with an edentulous maxilla and a bilateral free-ending situation in the mandible. Material and methods Thirty subjects were included. A new RPD was made and implant support was provided 3 months later. Treatment costs (opportunity costs and costs based on tariffs) were calculated. Treatment effect was expressed by means of the Dutch ...περισσότερα »
The predictive value of microbiological findings on teeth, internal and external implant portions in clinical decision making
[image: cover.gif?v=1&s=ea3ed681cef4af2a1760b136] Abstract Aim The primary aim of this study was to evaluate 23 pathogens associated with peri-implantitis at inner part of implant connections, in peri-implant and periodontal pockets between patients suffering peri-implantitis and participants with healthy peri-implant tissues; the secondary aim was to estimate the predictive value of microbiological profile in patients wearing dental implants using data mining methods. Material and Methods Fifty participants included in the present case─control study were scheduled for collection ...περισσότερα »
Transnasal endoscopic resection of vascular leiomyomas of the nasal septum
Transnasal endoscopic resection of vascular leiomyomas of the nasal septum: *Hai-Hong Chen, Qin-Ying Wang, Shui-Hong Zhou* Journal of Cancer Research and Therapeutics 2016 12(1):109-111 Objective: Our experience with endoscopic surgery for vascular leiomyomas of the nasal septum was reviewed. Patients and Methods: All patients with vascular leiomyomas of the nasal septum who were treated with endoscopic surgery from May 1995 to June 2007 were reviewed retrospectively. Results: Twelve patients had vascular leiomyomas of the nasal septum removed successfully; there were no recurr...περισσότερα »
Buccal carcinoma : Cerrobend shielding stents in preventing adverse radiotherapeutic effects
A pilot study to evaluate the efficacy of cerrobend shielding stents in preventing adverse radiotherapeutic effects in buccal carcinoma patients: *Karma Yangchen, Ramashanker Siddharth, Saumyendra V Singh, Raghuwar D Singh, Himanshi Aggarwal, Niraj Mishra, Shuchi Tripathi, Kirti Srivastava, Teethraj Verma, Pradeep Kumar* Journal of Cancer Research and Therapeutics 2016 12(1):314-317 Background: Radiation stents made of Lipowitz metal or cerrobend alloy are commonly used to shield uninvolved tissues from electron beams used in therapeutic radiation treatment of head and neck canc...περισσότερα »
Clinical relevance of using autofluorescence bronchoscopy and white light bronchoscopy in different types of airway lesions
Clinical relevance of using autofluorescence bronchoscopy and white light bronchoscopy in different types of airway lesions: *Zheng Liu, Ye Zhang, Yin-Peng Li, Jiao Ma, Fang Shi, Dong-Fang Zhao, Jian-Min Li, Yan-Zong Zhang* Journal of Cancer Research and Therapeutics 2016 12(1):69-72 Objectives: The aim of this study was to evaluate the sensitivity and specificity of autofluorescence bronchoscopy (AFB) according to the macroscopic appearance of airway lesions under white light bronchoscopy (WLB). Materials and Methods: The bronchoscopic findings of 708 patients, who were pathol... περισσότερα »
Analysis of failure patterns in patients with resectable esophageal squamous cell carcinoma receiving chemoradiotherapy
Analysis of failure patterns in patients with resectable esophageal squamous cell carcinoma receiving chemoradiotherapy: *Wen-Bin Shen, Shu-Chai Zhu, Hong-Mei Gao, You-Mei Li, Jin-Wei Su, Juan Li, Zhi-Kun Liu* Journal of Cancer Research and Therapeutics 2016 12(1):62-68 Purpose: This study investigates the failure pattern after chemoradiotherapy of patients with resectable esophageal squamous cell carcinoma (ESCC). Materials and Methods: We retrospectively analyzed 92 patients with T1-2, N0-1, and M0 ESCC. These patients were inoperable because of poor performance, comorbiditie...περισσότερα »
Dihydroartemisinin inhibits cell proliferation by induced G1 arrest and apoptosis in human nasopharyngealcarcinoma cells
Dihydroartemisinin inhibits cell proliferation by induced G1 arrest and apoptosis in human nasopharyngealcarcinoma cells: *Zhenhe Huang, Xueqin Huang, Donghui Jiang, Yuefei Zhang, Bo Huang, Guoqing Luo* Journal of Cancer Research and Therapeutics 2016 12(1):244-247 Context: Dihydroartemisinin (DHA) exhibits anticancer activity in a number of human cancer cells. However, it is still unknown whether DHA has anticancer effect on nasopharyngeal cancer (NPC) cells. Aims: To investigate the anticancer activity of DHA on CNE-2 cells. Materials and Methods: Cell cycleand invasion assay ...περισσότερα »
Bioinformatic analysis of c-Myc target from laryngeal cancer cell gene of laryngeal cancer
Bioinformatic analysis of c-Myc target from laryngeal cancer cell gene of laryngeal cancer: *Wei-Dong Zhang, He-Xin Chen, Yun-Xia Wang, Zhi-Ping Chen, Zhong-Jie Shan, Guang Xu* Journal of Cancer Research and Therapeutics 2016 12(1):58-61 Aim of Study: The aim was to explore the structure and functions of new target spot c-Myc target from laryngeal cancer cell. (MTLC) of c-Myc gene. Methods: This study adopted bioinformatic methods to analyze the physicochemical property, secondary structure, hydrophobic region, a transmembrane region, and prediction of functions. Results: The r...περισσότερα »
Transforming growth factor beta1 gene in oral submucous fibrosis
Evaluation of transforming growth factor beta1 gene in oral submucous fibrosis induced in Sprague-Dawley rats by injections of areca nut and pan masala (commercial areca nut product) extracts: *Shilpa Maria, Venkatesh V Kamath, Krishnanand Satelur, Komali Rajkumar* Journal of Cancer Research and Therapeutics 2016 12(1):379-385 Context: Oral submucous fibrosis (OSF) is a potentially malignant oral disorder causally linked to the habit of chewing arecanut. The pathogenesis of the disorder is multifactorial and transforming growth factor beta (TGF-beta) is a prominent player in the... περισσότερα »
IVM Imaging EMT.The activation of the epithelial-to-mesenchymal transition (EMT) program is a critical step in cancer progression and metastasis
IVM Imaging EMT: The activation of the epithelial-to-mesenchymal transition (EMT) program is a critical step in cancer progression and metastasis, but visualization of this process at the single-cell level, especially in vivo, remains challenging. We established an in vivo approach to track the fate of tumor cells based on a novel EMT-driven fluorescent color switching breast cancer mouse model and intravital two-photon laser scanning microscopy. Specifically, the MMTV-PyMT, Rosa26-RFP-GFP, and Fsp1-Cre triple transgenic mouse model was used to monitor the conversion of RFP-positive... περισσότερα »
Brain Cancer Stem Cell Organoids
Brain Cancer Stem Cell Organoids: Many cancers feature cellular hierarchies that are driven by tumor-initiating cancer stem cells (CSC) and rely on complex interactions with the tumor microenvironment. Standard cell culture conditions fail to recapitulate the original tumor architecture or microenvironmental gradients and are not designed to retain the cellular heterogeneity of parental tumors. Here, we describe a three-dimensional culture system that supports the long-term growth and expansion of tumor organoids derived directly from glioblastoma specimens, including patient-derive... περισσότερα »
Vitamin D and Lung Function Decline in Adults With Asthma: The HUNT Study
Vitamin D and Lung Function Decline in Adults With Asthma: The HUNT Study: We investigated whether low 25-hydroxyvitamin D (25(OH)D) levels were associated with more lung function decline in adults with asthma and whether this association was modified by smoking status or inhaled corticosteroid (ICS) use. We analyzed data on 395 adults with asthma from the Nord-Trøndelag Health Study (1995–2008), Norway. Plasma 25(OH)D and lung function were measured at baseline, and lung function measurements were repeated at follow-up, approximately 11 years later. Linear regression was used to e... περισσότερα »
Herpes Zoster After Varicella Immunization
The Epidemiology of Herpes Zoster After Varicella Immunization Under Different Biological Hypotheses: Perspectives From Mathematical Modeling: The impact of varicella vaccination on the epidemiology of herpes zoster (HZ) critically depends on the mechanism of immunological boosting, through which reexposures to varicella-zoster virus are thought to reduce the individual risk of HZ development. However, the qualitative and quantitative dynamics of this process are largely unknown. Consequently, mathematical models evaluating immunization strategies need to rely on theoretical assump... περισσότερα »
NOTCH1-Driven Cancer Stem Cells in Adenoid Cystic Carcinoma
NOTCH1-Driven Cancer Stem Cells in Adenoid Cystic Carcinoma: *Purpose:* Although the existence of cancer stem cells (CSC) in adenoid cystic carcinoma (ACC) has been proposed, lack of assays for their propagation and uncertainty about molecular markers prevented their characterization. Our objective was to isolate CSC from ACC and provide insight into signaling pathways that support their propagation. *Experimental Design:* To isolate CSC from ACC and characterize them, we used ROCK inhibitor-supplemented cell culture, immunomagnetic cell sorting, and *in vitro/in vivo* assays for C...περισσότερα »
Palbociclib-Induced Bone Marrow Suppression
Mechanism of *Purpose:* Palbociclib (PD-0332991) is the first selective cyclin-dependent kinase (CDK) 4/6 inhibitor approved for metastatic breast cancer. Hematologic effects, especially neutropenia, are dose-limiting adverse events for palbociclib in humans. *Experimental Design:* Reversible hematologic effects and bone marrow hypocellularity have been identified in toxicology studies in rats and dogs after palbociclib treatment. To understand the mechanism by which the hematologic toxicity occurs, and to further differentiate it from the myelotoxicity caused by cytotoxic chemoth...περισσότερα »
Dendritic Cell Vaccines
Dendritic Cell Vaccines: Dendritic cell (DC) vaccination in cancer patients aims to induce or augment an effective antitumor immune response against tumor antigens and was first explored in a clinical trial in the 1990s. More than two decades later, numerous clinical trials have been performed or are ongoing with a wide variety of DC subsets, culture protocols, and treatment regimens. The safety of DC vaccination and its ability to induce antitumor responses have clearly been established; however, although scattered patients with long-term benefit were reported, DC vaccines have no... περισσότερα »
Synchronous biphenotypic Richter syndrome with EBV positive nodal classical Hodgkin lymphoma and bone marrow diffuse large B-cell lymphoma
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
Abstract We report a rare case of Richter transformation (RT) with synchronous Hodgkin lymphoma (HL) and diffuse large B-cell lymphoma (DLBCL). A female patient otherwise in good health was diagnosed at 54 years of age with Binet stage A chronic lymphocytic leukemia (CLL). After an observation period lasting two years, treatment with fludarabine and cyclophosphamide was initiated for rapid lymphocyte doubling time. Conventional cytogenetic analysis at baseline was normal; fluorescence *in situ* hybridization (FISH) was not performed. She completed six cycles of therapy and achieved...περισσότερα »
Issue Information - TOC
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1p32Nc4 via IFTTT
Immune Monitoring for Cancer Immunotherapies
Immune Monitoring for Cancer Immunotherapies: Clinical trials with immune checkpoint inhibitors have provided important insights into the mode of action of anticancer immune therapies and potential mechanisms of immune escape. Development of the next wave of rational clinical combination strategies will require a deep understanding of the mechanisms by which combination partners influence the battle between the immune system's capabilities to fight cancer and the immune-suppressive processes that promote tumor growth. This review focuses on our current understanding of tumor and ci...περισσότερα »
T-cell Exhaustion in Cancer
T-cell Exhaustion in Cancer: In the context of chronic antigen exposure in chronic viral infections and cancer, T cells become exhausted/dysfunctional. These exhausted T cells exhibit defective proliferative capacities and cytokine production, but are not totally inert and may exert lytic functions. Importantly, exhausted T cells upregulate multiple inhibitory receptors/immune checkpoints that bind to their ligands expressed by tumor cells and antigen-presenting cells in the tumor microenvironment (TME). Immune checkpoint blockades with anti-CTL antigen 4 (CTLA-4) and/or anti-progr... περισσότερα »
Opportunities and Challenges in Cancer Immunotherapy
Opportunities and Challenges in Cancer Immunotherapy: Immunotherapy strategies against cancer are emerging as powerful weapons for treatment of this disease. The success of checkpoint inhibitors against metastatic melanoma and adoptive T-cell therapy with chimeric antigen receptor T cells against B-cell–derived leukemias and lymphomas are only two examples of developments that are changing the paradigms of clinical cancer management. These changes are a result of many years of intense research into complex and interrelated cellular and molecular mechanisms controling immune respons... περισσότερα »
NK Cell-Based Cancer Immunotherapy
NK Cell-Based Cancer Immunotherapy: The article by Curti and colleagues highlights the potential of natural killer (NK) cell–based adoptive cellular immunotherapy in oncology, currently boosted by advances in the knowledge on NK cell biology and in their *ex vivo* GMP manipulation. Several issues deserve attention to fully achieve the translation of these advances to the clinic. *Clin Cancer Res; 22(8); 1831–3. ©2016 AACR*. *See related article by Curti et al., p. 1914*
Inhibition of PI3K{alpha} Radiosensitizes Head and Neck Tumors
Inhibition of PI3K{alpha} Radiosensitizes Head and Neck Tumors: *Purpose:* Activating *PIK3CA* genomic alterations are frequent in head and neck squamous cell carcinoma (HNSCC), and there is an association between phosphoinositide 3-kinase (PI3K) signaling and radioresistance. Hence, we investigated the therapeutic efficacy of inhibiting PI3K with GDC-0032, a PI3K inhibitor with potent activity against p110α, in combination with radiation in HNSCC. *Experimental Design:* The efficacy of GDC-0032 was assessed *in vitro* in 26 HNSCC cell lines with crystal violet proliferation assays...περισσότερα »
The component-specific to total IgE ratios do not improve peanut and hazelnut allergy diagnoses
The component-specific to total IgE ratios do not improve peanut and hazelnut allergy diagnoses via Allergy and Clinical Immunology Publication date: Available online 14 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Linus Grabenhenrich, Lars Lange, Magdalena Härtl, Birgit Kalb, Mandy Ziegert, Antje Finger, Neda Harandi, Ruppert Schlags, Monika Gappa, Letizia Puzzo, Volker Stephan, Thomas Heigele, Susanne Büsing, Hagen Ott, Bodo Niggemann, Kirsten Beyer BackgroundSpecific IgE measurement predicts the outcome of oral food challenges with considerable uncertain... περισσότερα »
Vaccines targeting dendritic cells by coupling allergoids to non-oxidized mannan enhance allergen uptake and induce functional regulatory T cells via PD-L1
Novel via Allergy and Clinical Immunology Publication date: Available online 13 April 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Sofía Sirvent, Irene Soria, Cristina Cirauqui, Bárbara Cases, Ana I. Manzano, Carmen M. Diez-Rivero, Pedro A. Reche, Juan López-Relaño, Eduardo Martínez-Naves, F. Javier Cañada, Jesús Jiménez-Barbero, Javier Subiza, Miguel Casanovas, Enrique Fernández-Caldas, José Luis Subiza, Oscar Palomares BackgroundAllergen-immunotherapy (AIT) is the only curative treatment for allergy. AIT faces pitfalls related to efficacy, security, duration a... περισσότερα »
Successful Anti-PD-1 Antibody Treatment in a Metastatic Melanoma Patient With Known Severe Autoimmune Disease
Successful Anti-PD-1 Antibody Treatment in a Metastatic Melanoma Patient With Known Severe Autoimmune Disease: [image: image]Pembrolizumab, an anti-programmed death-1 monoclonal antibody, has been approved by the Food and Drug Administration in 2014 on the basis of improved progression-free and overall survival in metastatic melanoma. We report for the first time a successful treatment with a programmed death-1 antibody in a 69-year-old metastastic melanoma patient with a Churg-Strauss lung vasculitis and a prior ipilimumab-induced autoimmune colitis. This case report suggests that ...περισσότερα »
Combined Cancer Immunotherapy Against Aurora Kinase A
Combined Cancer Immunotherapy Against Aurora Kinase A: [image: image]Aurora kinase A (AURKA) is a centrosomal protein that is overexpressed in a number of human malignancies and can contribute to tumor progression. As we used this protein as a target of DNA immunization, we increased its immunogenicity by the addition of the PADRE helper epitope and decreased its potential oncogenicity by mutagenesis of the kinase domain. For in vitro analysis of induced immune responses in mice, we identified the Aurka220–228 nonapeptide representing an H-2Kb epitope. As DNA vaccination against the... περισσότερα »
Primary Mammary Analog Secretory Carcinoma (MASC) of the Thyroid Masquerading as Papillary Thyroid Carcinoma: Potentially More than a One Off
A Case of AbstractWe present the second reported mammary analog secretory carcinoma (MASC) apparently arising in the thyroid and propose a potential close relationship to *ETV6*-*NTRK3* fusion papillary thyroid carcinoma. The patient, a 36 year old woman, presented with a neck mass of 1 year’s duration. Imaging studies showed a tumor involving most of the thyroid with enlarged regional lymph nodes. FNA biopsy yielded a diagnosis of “papillary thyroid carcinoma”. Resection revealed a 4.5 cm infiltrative tumor. Final diagnosis was “papillary thyroid carcinoma (PTC) consistent with di... περισσότερα »
Effectiveness and Safeness of Different Amifostine Regimens
A Phase II Clinical Trial on Comparison of Effectiveness and Safeness of Different Amifostine Regimens: *Conditions*: Nasopharyngeal Neoplasms; Salivary Gland Diseases; Bone Marrow Diseases; Mucositis *Interventions*: Drug: Amifostine every-other-day regimen; Drug: Amifostine everyday regimen *Sponsors*: Sun Yat-sen University; Dalian Merro Pharmaceutical Co. Ltd ArmsAssigned Interventions No Intervention: Program I Patients with American Joint Cancer Committee/Union Internationale Contre le Cancer (UICC/AJCC) 2010 Stage I and II; Radiotherapy applied Experimental: ...περισσότερα »
Hemoglobin, Neutrophil to Lymphocyte Ratio and Platelet Count Improve Prognosis Prediction in Nasopharyngeal Carcinoma
Hemoglobin, Neutrophil to Lymphocyte Ratio and Platelet Count Improve Prognosis Prediction in Nasopharyngeal Carcinoma: *Conditions*: Nasopharyngeal Neoplasms; Blood Cell Count; Neoplasm Staging; Prognosis *Intervention*: *Sponsor*: Sun Yat-sen University Groups/Cohorts Low Risk Group Each of the eight independent prognostic factors (age, sex, T and N stages, hemoglobin during radiotherapy, variation tendency of Hb, neutrophil-lymphocyte ratio before radiotherapy and platelet during radiotherapy) was assigned a number of points proportional to its regression coeffic...περισσότερα »
Tooth filling in school dental clinic Part 2
The post Tooth filling in school dental clinic Part 2 appeared first on Family Dentistry and Cosmetic Surgery Clinic. from #Dental via xlomafota13 on Inoreader http://ift.tt/1Mx90Z8 via IFTTT
Hyperbaric Oxygen and Its Effect on Radiation Induced Long Term Side Effects
Hyperbaric Oxygen and Its Effect on Radiation Induced Long Term Side Effects: *Condition*: Cancer of Head and Neck *Intervention*: *Sponsor*: State University of New York - Upstate Medical University Groups/Cohorts Treated with HBO QOL questionnaires at 5 time points for those having HBO therapy at least one year post radiation therapy for head and neck cancer, daily x6 weeks Not treated with HBO QOL questionnaires for those at least one year post radiation therapy for head and neck cancer at 5 times points. Detailed Description: Radiation therapy is a commonly utilized trea... περισσότερα »
Laser Therapy for the Prevention of Radiodermatitis in Head and Neck Patients
Laser Therapy for the Prevention of Radiodermatitis in Head and Neck Patients: *Conditions*: Head Cancer; Neck Cancer *Interventions*: Device: Low-level laser therapy; Device: sham laser *Sponsors*: Hasselt University; Jessa Hospital Up to 90% of the radiotherapy patients will develop a certain degree of skin reaction at the treated area, also known as radiodermatitis (RD). Currently, there is a wide variety of strategies to manage RD, including creams, gels, ointments, wound dressings. However, up to now, there is still no comprehensive, evidence-based consensus for th... περισσότερα »
Airway Changes in Patients Undergoing Elective Surgical Procedures in the Prone and Trendelenburg Positions
Airway Changes in Patients Undergoing Elective Surgical Procedures in the Prone and Trendelenburg Positions: *Condition*: Airway Management *Intervention*: Other: Intubation *Sponsor*: Tufts Medical Center The goal of this study is to track the intraoperative changes that occur in the airways of patients undergoing 1) laparoscopic surgeries in the Trendelenburg position, and 2) spinal surgeries in the prone position, as well as the regression of these changes postoperatively. These surgeries are known to cause edema and swelling of the soft tissues of thehead and neck, temp...περισσότερα »
Recurrent, Slow-Growing Retropharyngeal Lesion
Recurrent, Slow-Growing Retropharyngeal Lesion: A woman with a history of a benign retropharyngeal mass reported return of her symptoms, including mouth breathing, snoring, nasal obstruction, Eustachian tube dysfunction, and transient upper extremity paraplegias; MRI revealed a complete recurrence and enlargement of the mass. What is your diagnosis? [image: First page PDF preview]
Painful Soft-Tissue Nodules of the Forehead
A Woman With Painful Soft-Tissue Nodules of the Forehead: A woman had severe frontal and periorbital headaches and multiple prominent soft, tender nodules at the forehead and right orbit with right proptosis; a computed tomographic scan showed a soft-tissue mass with involvement of multiple craniofacial bones. What is your diagnosis? [image: First page PDF preview]
Association Between Comorbidity and p16 in Oropharyngeal SCC
Association Between Comorbidity and p16 in Oropharyngeal SCC: This cohort study examines comorbidity and survival among p16-positive and p16-negative patients with oropharyngeal squamous cell carcinoma. *Importance* Comorbidity affects the prognosis of patients with cancer through the direct effects of the comorbid illness and by influencing the patients’ ability to tolerate treatment and mount a host response. However, the prognostic importance of comorbidity in oropharyngeal squamous cell carcinoma is not well characterized in the era of human papillomavirus infection. *Object...περισσότερα »
Risk Factors for Unplanned Readmission in Parotid Cancer Surgery
Risk Factors for Unplanned Readmission in Parotid Cancer Surgery: This study of patient records in the National Cancer Database examines the incidence of 30-day unplanned readmission for patients undergoing parotidectomy for treatment of parotid cancer. *Importance* Thirty-day unplanned readmissions are increasingly used as a measure of quality care. *Objective* To describe the incidence of and risk factors for 30-day unplanned readmissions for patients undergoing treatment for cancer of the parotid gland. *Design, Setting, and Participants* A retrospective cohort study was co...περισσότερα »
Targetable ERBB2 Aberrations in Head and Neck Squamous Cell Carcinoma
Targetable ERBB2 Aberrations in Head and Neck Squamous Cell Carcinoma: This case series examines ERBB2 aberrations in tumor samples from patients with laryngeal and oral cavity squamous cell carcinoma. *Importance* *ERBB2* (formerly *HER2*) is an important drug target in breast cancer, where anti-ERBB2 therapy has been shown to lead to improvements in disease recurrence and overall survival.*ERBB2* status in head and neck squamous cell carcinoma (HNSCC) has not been well studied. Identification of *ERBB2*-positive tumors and characterization of response to ERBB2 therapy could le... περισσότερα »
Asymptomatic Dorsal Tongue Mass
Asymptomatic Dorsal Tongue Mass: A woman had a progressively enlarging lump on her tongue; the size caused intermittent gagging and a foreign-body sensation in her throat; examination revealed a pedunculated mass of the posterior dorsal tongue just lateral to the circumvallate papillae. What is your diagnosis? [image: First page PDF preview]
The Reliability of Pharyngeal High Resolution Manometry with Impedance for Derivation of Measures of Swallowing Function in Healthy Volunteers
The Reliability of Pharyngeal High Resolution Manometry with Impedance for Derivation of Measures of Swallowing Function in Healthy Volunteers: Purpose. We evaluated the intra- and interrater agreement and test-retest reliability of analyst derivation of swallow function variables based on repeated high resolution manometry with impedance measurements. Methods. Five subjects swallowed mL saline on two occasions one week apart producing a database of 100 swallows. Swallows were repeat-analysed by six observers using software. Swallow variables were indicative of contractility, intrab...περισσότερα »
Treatment of large tracheal defects after resection: Laryngotracheal release and tracheal replacement
Treatment of large tracheal defects after resection: Laryngotracheal release and tracheal replacement: Resection with direct tracheal or laryngotracheal anastomosis is the standard procedure employed for treatment of benign stenosis or occasionally primary or secondary tracheal malignancy. AbstractObjective Resection with direct tracheal or laryngotracheal anastomosis is the standard procedure employed for treatment of benign stenosis or occasionally primary or secondary tracheal malignancy. Data sources Literature review. Results A tracheal anastomosis usually heals without compl...περισσότερα »
Cavernous sinus thrombosis during pregnancy
Cavernous sinus thrombosis during pregnancy: Abstract Cavernous sinus thrombosis (CST) represents a rare but devastating disease process that may be associated with significant long-term patient morbidity or mortality. Rapid diagnosis and aggressive medical and surgical management are imperative for patients with CST. We present the case of a 24-year-old pregnant woman with intraorbital abscess and CST secondary to *Streptococcus milleri*. Surgical intervention included orbital abscess drainage and dental extraction, medical therapy included intravenous antibiotic, heparin, and ...περισσότερα »
Complications after cochlear implantation in adult patients
10-Year retrospective analysis of a tertiary academic centre: Cochlear implants (CI) are electronic devices that enable the auditory rehabilitation and the management of individuals with severe to profound bilateral hearing loss, and nowadays, advanced age is not considered a contraindication for cochlear implantation and several studies have shown that older adults do benefit from CI, with improvements in hearing abilities and quality of life. AbstractObjective Cochlear implants (CI) are electronic devices that enable the auditory rehabilitation and the management of individual... περισσότερα »
Stafne bone cavity containing ectopic parotid gland
Stafne bone cavity containing ectopic parotid gland via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 14 April 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Mesut Kaya, Kadriye Serife Ugur, Elif Dagli, Hanifi Kurtaran, Mehmet Gunduz Introduction In 1942, Stafne1 described 35 asymptomatic cases of a cortical depression of the lingual side of mandible with unilateral radiolucent cavities located in the posterior region of the mandible, between the third molar and mandibular angle, below the inferior mandibular ca... περισσότερα »
Bruxism in Movement Disorders
A Comprehensive Review: Abstract Bruxism is an abnormal repetitive movement disorder characterized by jaw clenching and tooth gnashing or grinding. It is classified into two overlapping types: awake bruxism (AB) and sleep bruxism (SB). Theories on factors causing bruxism are a matter of controversy, but a line of evidence suggests that it may to some extent be linked to basal ganglia dysfunction although so far, this topic has received little attention. The purpose of this article was to review cases of bruxism reported in various movement disorders. The biomedical literature was s... περισσότερα »
Effects of different cusp coverage restorations on the fracture resistance of endodontically treated maxillary premolars
Publication date: Available online 14 April 2016 *Source:*The Journal of Prosthetic Dentistry Author(s): Tugba Serin Kalay, Tahsin Yildirim, Mustafa Ulker Statement of problemCusp coverage restorations for the restoration of endodontically treated teeth represent a more conservative approach in terms of function and esthetics. However, limited scientific data are available regarding the optimum reduction design and thicknesses.PurposeThe purpose of this in vitro study was to evaluate the fracture resistance and fracture patterns of cusp coverage restorations with different cusp redu... περισσότερα »
Subjective qualitative assessment of the finish line of prosthetic preparations submitted to different finishing instruments
Publication date: Available online 14 April 2016 *Source:*The Journal of Prosthetic Dentistry Author(s): Tallita Foglietto da Silva, Murilo Pereira de Melo, Jefferson Ricardo Pereira, Wilton Mitsunari Takeshita, Bruno Mafra Ceribelli, Lilian Cristina Vessoni Iwaki Statement of problemDifferent instruments have been developed to improve crown finish lines after conventional preparation with diamond rotary instruments. However, more evidence on the effectiveness of these instruments is required.Purpose of studyThe purpose of this in vitro study was to assess the effectiveness of 4 dif... περισσότερα »
PRESSURE DISTENSION IN LEG VESSELS AS INFLUENCED BY PROLONGED BEDREST AND A PRESSURE HABITUATION REGIMEN
Bedrest increases pressure distension in arteries, arterioles and veins of the leg. We hypothesized that bedrest-induced deconditioning of leg vessels is governed by the removal of the local increments in transmural pressure induced by assuming erect posture, and therefore can be counteracted by intermittently increasing local transmural pressure during the bedrest. Ten men underwent 5 weeks of horizontal bedrest. A subatmospheric pressure (-90 mmHg) was intermittently applied to one lower leg (pressure habituation, PH leg). Vascular pressure distension was investigated before and ...περισσότερα »
A Machine Learning Approach for Computation of Fractional Flow Reserve from Coronary Computed Tomography
Fractional Flow Reserve (FFR) is a functional index quantifying the severity of coronary artery lesions, and is clinically obtained using an invasive, catheter-based measurement. Recently, physics-based models have shown great promise in being able to non-invasively estimate FFR from patient-specific anatomical information, e. g. obtained from computed tomography (CT) scans of the heart and the coronary arteries. However, these models have high computational demand, limiting their clinical adoption. In this manuscript, we present a machine learning-based model for predicting FFR a...περισσότερα »
Seasonal influence on stimulated BAT activity in prospective trials - A retrospective analysis of BAT visualized on 18F-FDG PET-CTs and 123I-mIBG SPECT-
Retrospective studies have shown that outdoor temperature influences the prevalence of detectable brown adipose tissue (BAT). Prospective studies use acute cold exposure to activate BAT. In prospective studies, BAT might be preconditioned in winter months leading to an increased BAT response to various stimuli. Therefore, the aim of this study was to assess whether outdoor temperatures and other weather characteristics, modulate the response of BAT to acute cold. Methods To assess respectively metabolic BAT activity and sympathetic outflow to BAT, 64 18F-fluorodeoxyglucose positron...περισσότερα »
Gradient of learnability in teaching English pronunciation
to Korean learners: [image: cm_sbs_024_plain.png] This paper aims to propose a gradient of learnability as a criterion for setting priorities in pronunciation teaching. A total of 40 Korean subjects (mostly aged 12 year) were tested on their discrimination ability of English sounds before and after participating in a high variability phonetic training (HVPT) program for 4 weeks. This study shows highly promising results for pronunciation teaching with the HVPT method. First, lower level learners show greater improvements in phoneme discrimination ability compared to upper level l... περισσότερα »
Coupling of an active middle-ear implant to the long process of the incus using an elastic clip attachment
Coupling of an active middle-ear implant to the long process of the incus using an elastic clip attachment via Hearing Research [image: S03785955.gif] Publication date: Available online 13 April 2016 *Source:*Hearing Research Author(s): Sebastian P. Schraven, Robert Mlynski, Ernst Dalhoff, Andreas Heyd, Daniela Wildenstein, Kristen Rak, Andreas Radeloff, Rudolf Hagen, Anthony W. Gummer The active middle-ear implant Vibrant Soundbridge© (VSB) is used to treat mild-to-severe sensorineural hearing losses. The standard surgical approach for incus vibroplasty is a mastoidectomy and a post... περισσότερα »
The Future of Oncolytic Virotherapy with Reovirus
The Future of Oncolytic Virotherapy with Reovirus: The dominant cancer treatment modalities such as chemotherapy, radiotherapy, and even targeted kinase inhibitors and mAbs are limited by low efficacy, toxicity, and treatment-resistant tumor subclones. Oncolytic viral therapy offers a novel therapeutic strategy that has the potential to dramatically improve clinical outcomes. Reovirus, a double-stranded benign human RNA virus, is a leading candidate for therapeutic development and currently in phase III trials. Reovirus selectively targets transformed cells with activated Ras signa... περισσότερα »
Tooth filling in school dental clinic Part 2
The post Tooth filling in school dental clinic Part 2 appeared first on Family Dentistry and Cosmetic Surgery Clinic. from #Dental via xlomafota13 on Inoreader http://ift.tt/1Mx90Z8 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Invasive Streptococcus pneumoniae in Canada, 2011–2014: Characterization of new candidate 15-valent pneumococcal conjugate vaccine serotypes 22F and 33F
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Publication date: Available online 13 April 2016 Source:Vaccine Author(s): Alyssa R. Golden, Heather J. Adam, George G. Zhanel Emerging non-PCV-13 Streptococcus pneumoniae serotypes 22F and 33F are included in a new 15-valent pneumococcal conjugate vaccine currently undergoing clinical trials in the United States. This study assessed the antimicrobial resistance and genetic relatedness of these two […]
PRESSURE DISTENSION IN LEG VESSELS AS INFLUENCED BY PROLONGED BEDREST AND A PRESSURE HABITUATION REGIMEN
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Bedrest increases pressure distension in arteries, arterioles and veins of the leg. We hypothesized that bedrest-induced deconditioning of leg vessels is governed by the removal of the local increments in transmural pressure induced by assuming erect posture, and therefore can be counteracted by intermittently increasing local transmural pressure during the bedrest. Ten men underwent 5 […]
A Machine Learning Approach for Computation of Fractional Flow Reserve from Coronary Computed Tomography
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Fractional Flow Reserve (FFR) is a functional index quantifying the severity of coronary artery lesions, and is clinically obtained using an invasive, catheter-based measurement. Recently, physics-based models have shown great promise in being able to non-invasively estimate FFR from patient-specific anatomical information, e. g. obtained from computed tomography (CT) scans of the heart and the […]
Seasonal influence on stimulated BAT activity in prospective trials – A retrospective analysis of BAT visualized on 18F-FDG PET-CTs and 123I-mIBG SPECT-
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Retrospective studies have shown that outdoor temperature influences the prevalence of detectable brown adipose tissue (BAT). Prospective studies use acute cold exposure to activate BAT. In prospective studies, BAT might be preconditioned in winter months leading to an increased BAT response to various stimuli. Therefore, the aim of this study was to assess whether outdoor […]
The Role of Diet and Nutritional Status in Recovery from Hip Fracture in the Elderly
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Abstract Malnutrition is a significant risk factor for poor functional recovery following hip fracture. General undernutrition can be assessed using nutrition assessment screening tools. Identification of nutritionally at risk individuals may prevent complications and poor recovery following a fracture. Simple nutritional supplementation has not resulted in meaningful changes in health outcomes following fracture. However, newer […]
Body weight and sensitivity of screening mammography
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Publication date: June 2016 Source:European Journal of Cancer, Volume 60 Author(s): Sisse H. Njor, My von Euler-Chelpin, Anne Tjønneland, Ilse Vejborg, Elsebeth Lynge AimObese women tend to participate less in breast cancer screening than normal weight women. However, obese women have fattier breast than normal weight women, and screening mammography works better in fatty than […]
Effects of different cusp coverage restorations on the fracture resistance of endodontically treated maxillary premolars
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Publication date: Available online 14 April 2016 Source:The Journal of Prosthetic Dentistry Author(s): Tugba Serin Kalay, Tahsin Yildirim, Mustafa Ulker Statement of problemCusp coverage restorations for the restoration of endodontically treated teeth represent a more conservative approach in terms of function and esthetics. However, limited scientific data are available regarding the optimum reduction design and […]
Subjective qualitative assessment of the finish line of prosthetic preparations submitted to different finishing instruments
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Publication date: Available online 14 April 2016 Source:The Journal of Prosthetic Dentistry Author(s): Tallita Foglietto da Silva, Murilo Pereira de Melo, Jefferson Ricardo Pereira, Wilton Mitsunari Takeshita, Bruno Mafra Ceribelli, Lilian Cristina Vessoni Iwaki Statement of problemDifferent instruments have been developed to improve crown finish lines after conventional preparation with diamond rotary instruments. However, more […]
Bond strength of fiber posts to the root canal: Effects of anatomic root levels and resin cements
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Publication date: Available online 14 April 2016 Source:The Journal of Prosthetic Dentistry Author(s): Bruno Daleprane, Carolina N.B. Pereira, Audrey C. Bueno, Raquel C. Ferreira, Allyson N. Moreira, Cláudia S. Magalhães Statement of problemDecementation is one of the most frequent causes of failure in the post-cement system. The bond strength in different parts of the canal […]
Twelve-year survival of 2-surface composite resin and amalgam premolar restorations placed by dental students
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 52 δευτερόλεπτα
Publication date: Available online 14 April 2016 Source:The Journal of Prosthetic Dentistry Author(s): Safa Naghipur, Igor Pesun, Anthony Nowakowski, Aaron Kim Statement of problemComposite resin and amalgam restorations are indicated for the restoration of posterior teeth. With increased esthetic demands, long-term clinical studies are required to evaluate the restorative success and reasons for failure of […]
Correction: Lens Epithelium-Derived Growth Factor Is an Hsp70-2 Regulated Guardian of Lysosomal Stability in Human Cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 55 δευτερόλεπτα
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Retraction: High-Avidity T Cells Are Preferentially Tolerized in the Tumor Microenvironment
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 55 δευτερόλεπτα
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Retraction: Immunity to Murine Prostatic Tumors: Continuous Provision of T-Cell Help Prevents CD8 T-Cell Tolerance and Activates Tumor-Infiltrating Dendritic Cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 55 δευτερόλεπτα
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KRAS Mutation and MLL-AF4 in Cord Blood CD34+ Cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 55 δευτερόλεπτα
The MLL–AF4 (MA4) fusion gene is the genetic hallmark of an aggressive infant pro–B-acute lymphoblastic leukemia (B-ALL). Our understanding of MA4-mediated transformation is very limited. Whole-genome sequencing studies revealed a silent mutational landscape, which contradicts the aggressive clinical outcome of this hematologic malignancy. Only RAS mutations were recurrently detected in patients and found to be […]
MCAM and LAMA4 Are Vascular Targets in Renal Cancer
The structure and molecular signature of tumor-associated vasculature are distinct from those of the host tissue, offering an opportunity to selectively target the tumor blood vessels. To identify tumor-specific endothelial markers, we performed a microarray on tumor-associated and nonmalignant endothelium collected from patients with renal cell carcinoma (RCC), colorectal carcinoma, or colorectal liver metastasis. We… Continue reading MCAM and LAMA4 Are Vascular Targets in Renal Cancer
C GAMP, Where Is Thy STING?
Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are required for the function of STING (TMEM173), an ER-resident transmembrane protein critical for cytoplasmic DNA sensing, IFN production, and cancer control. Here we show that the IRE-1/XBP-1 pathway functions downstream of STING and that STING agonists selectively trigger mitochondria-mediated apoptosis in normal and malignant B… Continue reading C GAMP, Where Is Thy STING?
MTH1, Redox Environment, and Hypoxia Signaling
Cancer cells are commonly in a state of redox imbalance that drives their growth and survival. To compensate for oxidative stress induced by the tumor redox environment, cancer cells upregulate specific nononcogenic addiction enzymes, such as MTH1 (NUDT1), which detoxifies oxidized nucleotides. Here, we show that increasing oxidative stress in nonmalignant cells induced their sensitization… Continue reading MTH1, Redox Environment, and Hypoxia Signaling
Invasive Streptococcus pneumoniae in Canada, 2011–2014: Characterization of new candidate 15-valent pneumococcal conjugate vaccine serotypes 22F and 33F
Publication date: Available online 13 April 2016 Source:Vaccine Author(s): Alyssa R. Golden, Heather J. Adam, George G. Zhanel Emerging non-PCV-13 Streptococcus pneumoniae serotypes 22F and 33F are included in a new 15-valent pneumococcal conjugate vaccine currently undergoing clinical trials in the United States. This study assessed the antimicrobial resistance and genetic relatedness of these two… Continue reading Invasive Streptococcus pneumoniae in Canada, 2011–2014: Characterization of new candidate 15-valent pneumococcal conjugate vaccine serotypes 22F and 33F
PRESSURE DISTENSION IN LEG VESSELS AS INFLUENCED BY PROLONGED BEDREST AND A PRESSURE HABITUATION REGIMEN
Bedrest increases pressure distension in arteries, arterioles and veins of the leg. We hypothesized that bedrest-induced deconditioning of leg vessels is governed by the removal of the local increments in transmural pressure induced by assuming erect posture, and therefore can be counteracted by intermittently increasing local transmural pressure during the bedrest. Ten men underwent 5… Continue reading PRESSURE DISTENSION IN LEG VESSELS AS INFLUENCED BY PROLONGED BEDREST AND A PRESSURE HABITUATION REGIMEN
A Machine Learning Approach for Computation of Fractional Flow Reserve from Coronary Computed Tomography
Fractional Flow Reserve (FFR) is a functional index quantifying the severity of coronary artery lesions, and is clinically obtained using an invasive, catheter-based measurement. Recently, physics-based models have shown great promise in being able to non-invasively estimate FFR from patient-specific anatomical information, e. g. obtained from computed tomography (CT) scans of the heart and the… Continue reading A Machine Learning Approach for Computation of Fractional Flow Reserve from Coronary Computed Tomography
Seasonal influence on stimulated BAT activity in prospective trials – A retrospective analysis of BAT visualized on 18F-FDG PET-CTs and 123I-mIBG SPECT-
Retrospective studies have shown that outdoor temperature influences the prevalence of detectable brown adipose tissue (BAT). Prospective studies use acute cold exposure to activate BAT. In prospective studies, BAT might be preconditioned in winter months leading to an increased BAT response to various stimuli. Therefore, the aim of this study was to assess whether outdoor… Continue reading Seasonal influence on stimulated BAT activity in prospective trials – A retrospective analysis of BAT visualized on 18F-FDG PET-CTs and 123I-mIBG SPECT-
The Role of Diet and Nutritional Status in Recovery from Hip Fracture in the Elderly
Abstract Malnutrition is a significant risk factor for poor functional recovery following hip fracture. General undernutrition can be assessed using nutrition assessment screening tools. Identification of nutritionally at risk individuals may prevent complications and poor recovery following a fracture. Simple nutritional supplementation has not resulted in meaningful changes in health outcomes following fracture. However, newer… Continue reading The Role of Diet and Nutritional Status in Recovery from Hip Fracture in the Elderly
Body weight and sensitivity of screening mammography
Publication date: June 2016 Source:European Journal of Cancer, Volume 60 Author(s): Sisse H. Njor, My von Euler-Chelpin, Anne Tjønneland, Ilse Vejborg, Elsebeth Lynge AimObese women tend to participate less in breast cancer screening than normal weight women. However, obese women have fattier breast than normal weight women, and screening mammography works better in fatty than… Continue reading Body weight and sensitivity of screening mammography
Effects of different cusp coverage restorations on the fracture resistance of endodontically treated maxillary premolars
Publication date: Available online 14 April 2016 Source:The Journal of Prosthetic Dentistry Author(s): Tugba Serin Kalay, Tahsin Yildirim, Mustafa Ulker Statement of problemCusp coverage restorations for the restoration of endodontically treated teeth represent a more conservative approach in terms of function and esthetics. However, limited scientific data are available regarding the optimum reduction design and… Continue reading Effects of different cusp coverage restorations on the fracture resistance of endodontically treated maxillary premolars
Brain Cancer Stem Cell Organoids
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Many cancers feature cellular hierarchies that are driven by tumor-initiating cancer stem cells (CSC) and rely on complex interactions with the tumor microenvironment. Standard cell culture conditions fail to recapitulate the original tumor architecture or microenvironmental gradients and are not designed to retain the cellular heterogeneity of parental tumors. Here, we describe a three-dimensional culture […]
Stem-like Prostate Cancer Cells in Bone Marrow Metastases
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Bone metastasis is a leading cause of morbidity and mortality in prostate cancer. While cancer stem-like cells have been implicated as a cell of origin for prostate cancer metastasis, the pathways that enable metastatic development at distal sites remain largely unknown. In this study, we illuminate pathways relevant to bone metastasis in this disease. We […]
Targeting GBM Stem Cells through FACT by CBL0137
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The nearly universal recurrence of glioblastoma (GBM) is driven in part by a treatment-resistant subpopulation of GBM stem cells (GSC). To identify improved therapeutic possibilities, we combined the EGFR/HER2 inhibitor lapatinib with a novel small molecule, CBL0137, which inhibits FACT (facilitates chromatin transcription), a histone chaperone complex predominantly expressed in undifferentiated cells. Lapatinib and CBL0137 […]
Pdcd1 Gene Inactivation in Tumor-Reactive Lymphocytes
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Despite the promising efficacy of adoptive cell therapies (ACT) in melanoma, complete response rates remain relatively low and outcomes in other cancers are less impressive. The immunosuppressive nature of the tumor microenvironment and the expression of immune-inhibitory ligands, such as PD-L1/CD274 by the tumor and stroma are considered key factors limiting efficacy. The addition of […]
Polymerase {kappa} Confers Temozolomide Resistance
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The acquisition of drug resistance is a persistent clinical problem limiting the successful treatment of human cancers, including glioblastoma (GBM). However, the molecular mechanisms by which initially chemoresponsive tumors develop therapeutic resistance remain poorly understood. In this study, we report that Pol κ, an error-prone polymerase that participates in translesion DNA synthesis, was significantly upregulated […]
IVM Imaging EMT
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The activation of the epithelial-to-mesenchymal transition (EMT) program is a critical step in cancer progression and metastasis, but visualization of this process at the single-cell level, especially in vivo, remains challenging. We established an in vivo approach to track the fate of tumor cells based on a novel EMT-driven fluorescent color switching breast cancer mouse […]
Insulin-like Growth Factors and Prostate Cancer Risk
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 […]
An Integrated mRNA-lncRNA Signature in TNBC
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
While recognized as a generally aggressive disease, triple-negative breast cancer (TNBC) is highly diverse in different patients with variable outcomes. In this prospective observational study, we aimed to develop an RNA signature of TNBC patients to improve risk stratification and optimize the choice of adjuvant therapy. Transcriptome microarrays for 33 paired TNBC and adjacent normal […]
USP9X Role in Genome Stability
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Coordination of the multiple processes underlying DNA replication is key for maintaining genome stability and preventing tumorigenesis. CLASPIN, a critical player in replication fork stabilization and checkpoint responses, must be tightly regulated during the cell cycle to prevent the accumulation of DNA damage. In this study, we used a quantitative proteomics approach and identified USP9X […]
IL17 and Microbial-Induced Colon Cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
IL17-producing Th17 cells, generated through a STAT3-dependent mechanism, have been shown to promote carcinogenesis in many systems, including microbe-driven colon cancer. Additional sources of IL17, such as γδ T cells, become available under inflammatory conditions, but their contributions to cancer development are unclear. In this study, we modeled Th17-driven colon tumorigenesis by colonizing MinApc+/− mice […]
Invasive Streptococcus pneumoniae in Canada, 2011–2014: Characterization of new candidate 15-valent pneumococcal conjugate vaccine serotypes 22F and 33F
[image: S0264410X.gif] Publication date: Available online 13 April 2016 *Source:*Vaccine Author(s): Alyssa R. Golden, Heather J. Adam, George G. Zhanel Emerging non-PCV-13 Streptococcus pneumoniae serotypes 22F and 33F are included in a new 15-valent pneumococcal conjugate vaccine currently undergoing clinical trials in the United States. This study assessed the antimicrobial resistance and genetic relatedness of these two emerging pneumococcal serotypes. Of the 5075 invasive pneumococcal isolates collected in Canada from 2011 to 2014, 9.8% (497/5075) were serotype 22F and 3.2% (160... περισσότερα »
The Role of Diet and Nutritional Status in Recovery from Hip Fracture in the Elderly
Abstract Malnutrition is a significant risk factor for poor functional recovery following hip fracture. General undernutrition can be assessed using nutrition assessment screening tools. Identification of nutritionally at risk individuals may prevent complications and poor recovery following a fracture. Simple nutritional supplementation has not resulted in meaningful changes in health outcomes following fracture. However, newer multidisciplinary approaches to improving nutritional status are showing improved health care outcomes. Data on the effectiveness of individual nutrients ... περισσότερα »
Body weight and sensitivity of screening mammography
Publication date: June 2016 *Source:*European Journal of Cancer, Volume 60 Author(s): Sisse H. Njor, My von Euler-Chelpin, Anne Tjønneland, Ilse Vejborg, Elsebeth Lynge AimObese women tend to participate less in breast cancer screening than normal weight women. However, obese women have fattier breast than normal weight women, and screening mammography works better in fatty than in dense breasts. One might, therefore, hypothesise that obese women would actually benefit more from screening than other women.MethodsWe combined data from the Danish Diet, Cancer and Health study and the ... περισσότερα »
Histological and Mathematical Analysis of the Irreversibly Electroporated Liver Tissue
Irreversible electroporation has clinically been used to treat various types of cancer. A plan on how to apply irreversible electroporation before practicing is very important to increase the ablation area and reduce the side effects. Several electrical models have been developed to predict the ablation area with applied electric energy. In this experiment, the static relationship between applied electric energy and ablated area was mathematically and experimentally investigated at 10 hours after applying irreversible electroporation. We performed the irreversible electroporation ... περισσότερα »
Vitamin D Deficiency May Promote Spread of Some Breast Cancers
A deficiency in vitamin D is associated with tumor progression and metastasis in breast cancer, suggests a new study. The study, primarily conducted using cell lines and mice, also identified an association between vitamin D levels and the expression of *ID1*, an oncogene that has been associated with tumor growth and metastasis in breast cancer and other cancer types. from Cancer via ola Kala on Inoreader http://ift.tt/1RXBc7K via IFTTT
Toward Precision Therapy for Children with Cancer: An Interview with Dr. Javed Khan
*Based on the results of a new study, NCI is launching a clinical program called ClinOmics, which will use genomic approaches to help guide the treatment of patients with cancer who are treated at the NIH Clinical Center.* *In this interview, Javed Khan, M.D., of NCI's Center for Cancer Research (CCR), discusses the promise and the challenges of genome-based therapy for children and adults with cancer.* from Cancer via ola Kala on Inoreader http://ift.tt/1SaqA4g via IFTTT
Systemic Versus Local Therapies for Colorectal Cancer Pulmonary Metastasis: What to Choose and When?
Abstract Background Lung is the second most common site of colorectal cancer metastasis. Treatment is based mainly on systemic therapy which has largely evolved lately, but outcome remains relatively poor. The place of locoregional therapies as curative strategies is still debated. Method A systematic literature review was performed by the authors for systemic therapy, surgery, radiofrequency ablation (RFA), and stereotactic body radiation therapy (SBRT). The highest level of evidence for each strategy was presented. Major findings were addressed in a summarized and clinically re... περισσότερα »
Clinicopathological significance of Fas and Fas ligand expressions in esophageal cancer [Retraction].
Related Articles *Clinicopathological significance of Fas and Fas ligand expressions in esophageal cancer [Retraction].* Am J Cancer Res. 2016;6(1):126 Authors: Abstract [This retracts the article on p. 2865 in vol. 5, PMID: 26609492.]. PMID: 27073730 [PubMed] from Cancer via ola Kala on Inoreader http://ift.tt/23HpjH0 via IFTTT
P53 is required for Doxorubicin-induced apoptosis via the TGF-beta signaling pathway in osteosarcoma-derived cells.
Related Articles *P53 is required for Doxorubicin-induced apoptosis via the TGF-beta signaling pathway in osteosarcoma-derived cells.* Am J Cancer Res. 2016;6(1):114-25 Authors: Sun Y, Xia P, Zhang H, Liu B, Shi Y Abstract Osteosarcoma is the most common type of aggressive bone cancer. Current treatment strategies include surgical resection, radiation, and chemotherapy. Doxorubicin has been widely used as a chemotherapeutic drug to treat osteosarcoma. However, drug resistance has become a challenge to its use. In this study, p53-wild type U2OS and p53-null MG-63 osteosarcoma-der...περισσότερα »
Associations of intakes of magnesium and calcium and survival among women with breast cancer: results from Western New York Exposures and Breast Cancer (WEB) Study.
Related Articles *Associations of intakes of magnesium and calcium and survival among women with breast cancer: results from Western New York Exposures and Breast Cancer (WEB) Study.* Am J Cancer Res. 2016;6(1):105-13 Authors: Tao MH, Dai Q, Millen AE, Nie J, Edge SB, Trevisan M, Shields PG, Freudenheim JL Abstract Magnesium (Mg) and calcium (Ca) antagonizes each other in (re) absorption, cell cycle regulation, inflammation, and many other physiologic activities. However, few studies have investigated the association between magnesium and calcium intakes and breast cancer surviv...περισσότερα »
Synergistic combination of microtubule targeting anticancer fludelone with cytoprotective panaxytriol derived from panax ginseng against MX-1 cells in vitro: experimental design and data analysis using the combination index method.
Related Articles *Synergistic combination of microtubule targeting anticancer fludelone with cytoprotective panaxytriol derived from panax ginseng against MX-1 cells in vitro: experimental design and data analysis using the combination index method.* Am J Cancer Res. 2016;6(1):97-104 Authors: Zhang N, Fu JN, Chou TC Abstract This brief article focuses on two aims: i) To investigate the in vitro pharmaco-dynamic interactions of combining synthetic potent microtubule targeting anticancer agent, Fludelone (FD) with cyto-protective agent, Panaxytriol (PXT) derived from Panax ginseng... περισσότερα »
CPA4 is a promising diagnostic serum biomarker for pancreatic cancer.
Related Articles *CPA4 is a promising diagnostic serum biomarker for pancreatic cancer.* Am J Cancer Res. 2016;6(1):91-6 Authors: Sun L, Burnett J, Guo C, Xie Y, Pan J, Yang Z, Ran Y, Sun D Abstract CPA4 belongs to a member of the metallocarboxypeptidase family, and its expression in pancreatic cancer samples and clinical significance are still not investigated until now. In this study, we aimed to evaluate the level of CPA4 in pancreatic cancer samples and study its clinical implications as a diagnostic marker for pancreatic cancer. The levels of CPA4 in pancreatic cancer tissue...περισσότερα »
Low-Level Laser Therapy Promoted Aggressive Proliferation and Angiogenesis Through Decreasing of Transforming Growth Factor-β1 and Increasing of Akt/Hypoxia Inducible Factor-1α in Anaplastic Thyroid Cancer
Photomedicine and Laser Surgery , Vol. 0, No. 0. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1qKQN05 via IFTTT
Demonstration of Normal and Abnormal Fetal Brains Using 3D Printing from In Utero MR Imaging Data PEDIATRICS
SUMMARY: 3D printing is a new manufacturing technology that produces high-fidelity models of complex structures from 3D computer-aided design data. Radiology has been particularly quick to embrace the new technology because of the wide access to 3D datasets. Models have been used extensively to assist orthopedic, neurosurgical, and maxillofacial surgical planning. In this report, we… Continue reading Demonstration of Normal and Abnormal Fetal Brains Using 3D Printing from In Utero MR Imaging Data PEDIATRICS
Low-Level Laser Therapy Promoted Aggressive Proliferation and Angiogenesis Through Decreasing of Transforming Growth Factor-β1 and Increasing of Akt/Hypoxia Inducible Factor-1α in Anaplastic Thyroid Cancer
Photomedicine and Laser Surgery , Vol. 0, No. 0. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1qKQNgB via IFTTT
AIP mutations impair AhR signaling in pituitary adenoma patients fibroblasts and in GH3 cells
Germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene predispose humans to pituitary adenomas through unknown molecular mechanisms. The best-known interacting partner of AIP is the aryl hydrocarbon receptor (AhR), a transcription factor that mediates the effects of xenobiotics implicated in carcinogenesis. As 75% of AIP mutations disrupt the physical and/or functional interaction… Continue reading AIP mutations impair AhR signaling in pituitary adenoma patients fibroblasts and in GH3 cells
Sleeve resection for bronchial carcinoid tumour in two children under six years old
Paediatric tracheobronchial tumours are very rare, and pneumonectomy and lobectomy procedures are rarely indicated due to their surgical difficulties and high sequelae. Bronchoplastic techniques preserving lun… from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/264NVeV via IFTTT
Keytruda Nears Approval for Head and Neck Cancer – Curetoday.com
Curetoday.com Keytruda Nears Approval for Head and Neck Cancer Curetoday.com After a trial presented in 2015, the FDA granted a priority review designation to Keytruda (pembrolizumab) as a treatment for patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) following a platinum-based chemotherapy, … Priority review for Keytruda in head and neck… Continue reading Keytruda Nears Approval for Head and Neck Cancer – Curetoday.com
A phase II study of axitinib in advanced neuroendocrine tumors
Neuroendocrine tumors (NETs) are highly vascular neoplasms overexpressing vascular endothelial growth factor (VEGF) as well as VEGF receptors (VEGFR). Axitinib is a potent, selective inhibitor of VEGFR-1, -2 and -3, currently approved for the treatment of advanced renal cell carcinoma. We performed an open-label, two-stage design, phase II trial of axitinib 5 mg twice daily… Continue reading A phase II study of axitinib in advanced neuroendocrine tumors
Hepatitis C ups risk of head, neck cancers – ETHealthWorld.com
ETHealthWorld.com Hepatitis C ups risk of head, neck cancers ETHealthWorld.com Also paramount to the research, said Torres, was to control for smoking, a major risk factor for head and neck cancers. Therefore, they identified 694 control subjects, all with a diagnosis of smoking-related cancers (378 with lung, 168 with esophageal … from #Head and Neck… Continue reading Hepatitis C ups risk of head, neck cancers – ETHealthWorld.com
Low-Level Laser Therapy Promoted Aggressive Proliferation and Angiogenesis Through Decreasing of Transforming Growth Factor-β1 and Increasing of Akt/Hypoxia Inducible Factor-1α in Anaplastic Thyroid Cancer
Photomedicine and Laser Surgery , Vol. 0, No. 0. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1T8iucq via IFTTT
Exposure to bisphenol A enhanced lung eosinophilia in adult male mice
Bisphenol A (BPA) is useful in many manufacturing processes and is also found in commonly used consumer products. Previous experimental studies have reported that perinatal exposure to BPA promotes the develop… from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1VtlUdV via IFTTT
Verteporfin inhibits YAP function through up-regulating 14-3-3σ sequestering YAP in the cytoplasm.
Related Articles Verteporfin inhibits YAP function through up-regulating 14-3-3σ sequestering YAP in the cytoplasm. Am J Cancer Res. 2016;6(1):27-37 Authors: Wang C, Zhu X, Feng W, Yu Y, Jeong K, Guo W, Lu Y, Mills GB Abstract Yes-associated protein (YAP), the central mediator of Hippo pathway, not only regulates a diversity of cellular processes during… Continue reading Verteporfin inhibits YAP function through up-regulating 14-3-3σ sequestering YAP in the cytoplasm.
An analytical coupled technique for solving nonlinear large-amplitude oscillation of a conservative system with inertia and static non-linearity
Based on a new trial function, an analytical coupled technique (a combination of homotopy perturbation method and variational method) is presented to obtain the approximate frequencies and the corresponding pe… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qt0wIf via IFTTT
Prevalence in running events and running performance of endurance runners following a vegetarian or vegan diet compared to non-vegetarian endurance runners: the NURMI Study
Beneficial and detrimental effects of various vegetarian and vegan diets on the health status are well known. Considering the growing background numbers of vegetarians and vegans, the number of vegetarian and … from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qKB1T0 via IFTTT
Upregulation of H19 indicates a poor prognosis in gallbladder carcinoma and promotes epithelial-mesenchymal transition.
Related Articles Upregulation of H19 indicates a poor prognosis in gallbladder carcinoma and promotes epithelial-mesenchymal transition. Am J Cancer Res. 2016;6(1):15-26 Authors: Wang SH, Wu XC, Zhang MD, Weng MZ, Zhou D, Quan ZW Abstract The imprinted oncofetal long non-coding RNA H19 has been reported to be involved in many kinds of human cancers. However,… Continue reading Upregulation of H19 indicates a poor prognosis in gallbladder carcinoma and promotes epithelial-mesenchymal transition.
