Head and Neck Medicine by Alexandros G.Sfakianakis: 01/17/16

Κυριακή 17 Ιανουαρίου 2016

International Journal of Oncology,Molecular and Clinical Oncology

Impact of single‑nucleotide polymorphisms on radiation pneumonitis in cancer patients (Review)

Cheng‑Xian Guo, Jing Wang, Li‑Hua Huang, Jin-Gao Li, Xiang Chen

Association between shortage of energy supply and nuclear gene mutations leading to carcinomatous transformation (Review)

Jianping Du

View Abstract

PIM1 kinase as a promise of targeted therapy in prostate cancer stem cells (Review)

Yingqiu Xie, Samat Bayakhmetov

View Abstract

Expression of zinc finger E‑box‑binding homeobox factor 1 in epithelial ovarian cancer: A clinicopathological analysis of 238 patients

Xiufang Li, Ruixia Huang, Ruth Holm Li, Claes G. Trope, Jahn M. Nesland, Zhenhe Suo

View Abstract

CXCL10/CXCR3 overexpression as a biomarker of poor prognosis in patients with stage II colorectal cancer

Ming Bai, Xia Chen, Yi Ba

View Abstract

Presentation of multiple myeloma mimicking bone metastasis from colon adenocarcinoma: A case report and literature review

Haicheng Zhang, Jurong Lv, Chaoliang Lv, Hongmei Zhang

View Abstract

Tubular adenoma of the common bile duct with uptake in 18F‑FDG PET: A case report

Kentaro Hokonohara, Takehiro Noda, Hisanori Hatano, Akihiro Takata, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Takamichi Komori, Shunji Morita, Hiroshi Imamura, Takashi Iwazawa, Kenzo Akagi, Shiro Hayashi, Masami Inada, Shiro Adachi, Keizo Dono

View Abstract

Anaplastic carcinoma of the pancreas arising in an intraductal papillary mucinous neoplasm: A case report

Kensuke Fujii, Toshikatsu Nitta, Hiroshi Kawasaki, Jun Kataoka, Tomo Tominaga, Yoshihiro Inoue, Eiji Kadota, Takashi Ishibashi, Kazuhisa Uchiyama

View Abstract

Feasibility of intensity-modulated radiotherapy combined with gemcitabine and S-1 for patients with pancreatic cancer

Norifumi Kennoki, Hidetsugu Nakayama, Yuichi Nagakawa, Yuichi Hosokawa, Tomohiro Itonaga, Yu Tajima, Sachica Shiraishi, Ryuji Mikami, Akihiko Tsuchida, Koichi Tokuuye

View Abstract

Examination of the clinical efficacy of eribulin and trastuzumab in HER2‑positive recurrent breast cancer

Takayoshi Kiba, Nao Morii, Hirotoshi Takahashi, Shinji Ozaki, Misao Atsumi, Fumi Masumoto, Yoshimi Shitakubo, Hiroyasu Yamashiro

View Abstract

Determination of prognosis of Philadelphia chromosome‑negative myeloproliferative neoplasms with a simple clinical examination: Retrospective analysis of 71 patients in a single institution

Shinichi Ito, Yutaka Tsutsumi, Hiroyuki Ohigashi, Souichi Shiratori, Takanori Teshima

View Abstract

Epiglottic diffuse B‑cell malignant lymphoma: A case report

Hung‑Min Chang, Chiung‑Chon Li, Stella Chin‑Shaw Tsai, Tang‑Yi Tsao

View Abstract

TERT promoter mutations are rare in bone and soft tissue sarcomas of Japanese patients

Tsuyoshi Saito, Keisuke Akaike, Aiko Kurisaki‑Arakawa, Midori Toda‑Ishii, Kenta Mukaihara, Yoshiyuki Suehara, Tatsuya Takagi, Kazuo Kaneko, Takashi Yao

View Abstract

Expression of metabotropic glutamate receptor 4 in osteosarcoma

Shuo Wang, Xing Wei, Bingyao Chen, Min Zhao, Guangze Song, Zengliang Zhang, Nan Li

View Abstract

Management of the N0 neck in recurrent laryngeal squamous cell carcinoma

Pei‑Jing Li, Wei‑Han Hu, Ting Jin

View Abstract

Prognostic value of cancer stem cell marker CD133 expression in esophageal carcinoma: A meta-analysis

Yun-Peng Sui, Xue-Ping Jian, Li Ma, Gui-Zhen Xu, Huai-Wei Liao, Yan-Ping Liu, Hui-Cai Wen

View Abstract

Outcomes and toxicity of radiotherapy for refractory bone and soft tissue sarcomas

Hiroshi Doi, Ryoong‑Jin Oh, Hideharu Miura, Norihisa Masai, Hiroya Shiomi, Toshihiko Inoue

View Abstract

Unplanned discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia

Yutaka Tsutsumi, Shinichi Ito, Hiroyuki Ohigashi, Souichi Shiratori, Takanori Teshima

View Abstract

Clinical pretreatment risk factors and prediction of outcome using gallium 67 scintigraphy in patients with Hodgkin's lymphoma

Ignacio García Escobar, Ana López, Judit Rubio, David Pérez‑Callejo, Dolores Caballero Barrigón, Pilar Tamayo Alonso, Elena Almagro Casado, Mariano Provencio Pulla

View Abstract

Prognostic role of the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 in various cancers: A meta-analysis

Jin Yan, Xiaoying Zhou, Yini Dang, Chengqiang Yin, Guoxin Zhang

View Abstract

Novel agent induction therapy alone or followed by autologous stem cell transplantation in younger patients with multiple myeloma: A single‑center retrospective study of 114 cases

Yan Wang, Pengpeng Xu, Yubao Chen, Qingye Fan, Junmin Li, Weili Zhao, Jianqing Mi, Hua Yan

View Abstract

Follicular cholangitis associated with focal biliary stricture treated with left hepatectomy after 8 years of follow‑up: A rare case report

Ryusuke Saito, Toshikatsu Fukuda, Hironobu Amano, Masahiro Nakahara, Makoto Yoshida, Minoru Yamaki, Keiji Hanada, Shuji Yonehara, Toshio Noriyuki

View Abstract

Adequacy of endobronchial ultrasound‑guided transbronchial needle aspiration samples processed as histopathological samples for genetic mutation analysis in lung adenocarcinoma

Abiramy Jeyabalan, Nidhi Bhatt, Martin J. Plummeridge, Andrew R.L. Medford

View Abstract

Angiomyolipoma of the rib: A rare case report

Guang‑Xiang Chen, Mao‑Hua Wang, Chang‑Lie Hu, Guang‑Cai Tang, Fu‑Gang Han

View Abstract

Clinical outcome of immunotherapy with dendritic cell vaccine and cytokine‑induced killer cell therapy in hepatobiliary and pancreatic cancer

Lihong Zhang, Wei Zhu, Jiali Li, Xuejing Yang, Yanjie Ren, Jingxiu Niu, Yan Pang

View Abstract

Increased erythropoietin levels as a biomarker of pancreatic adenocarcinoma: A case report

Rafay Khan, Qiang Nai, Ping Zhang, Hongxiu Luo, Shraman Sen, Ibrahim Sidhom, Teena Mathew, Mohammad Islam, Shuvendu Sen, Abdalla Yousif

View Abstract

IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review)

Xinxin Long, Yingnan Ye, Lijie Zhang, Pengpeng Liu, Wenwen Yu, Feng Wei, Xiubao Ren, Jinpu Yu

View Abstract

Pemetrexed clinical studies in performance status 2 patients with non-small cell lung cancer (Review)

Ralph Zinner, Carla Visseren-Grul, David R. Spigel, Coleman Obasaju

View Abstract

Involvement of cyclic-nucleotide response element-binding family members in the radiation response of Ramos B lymphoma cells

Chiara Di Nisio, Silvia Sancilio, Viviana Di Giacomo, Monica Rapino, Laura Sancillo, Domenico Genovesi, Alessandro Di Siena, Rosa Alba Rana, Amelia Cataldi, Roberta Di Pietro

View Abstract

Apoptosis and antitumor effects induced by the combination of an mTOR inhibitor and an autophagy inhibitor in human osteosarcoma MG63 cells

Ryosuke Horie, Osamu Nakamura, Yoshiki Yamagami, Masaki Mori, Hideki Nishimura, Natsuko Fukuoka, Tetsuji Yamamoto

View Abstract

Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines

Shuntaro Mukai, Shota Moriya, Masaki Hiramoto, Hiromi Kazama, Hiroko Kokuba, Xiao-Fang Che, Tomohisa Yokoyama, Satoshi Sakamoto, Akihiro Sugawara, Toshiaki Sunazuka, Satoshi Ōmura, Hiroshi Handa, Takao Itoi, Keisuke Miyazawa

View Abstract

Decreased expression of RASSF1A tumor suppressor gene is associated with worse prognosis in clear cell renal cell carcinoma

Jakub Klacz, Piotr M. Wierzbicki, Agata Wronska, Agnieszka Rybarczyk, Marcin Stanislawowski, Tomasz Slebioda, Agata Olejniczak, Marcin Matuszewski, Zbigniew Kmiec

View Abstract

Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines

Ningning He, Nayoung Kim, Euna Jeong, Yiling Lu, Gordon B. Mills, Sukjoon Yoon

View Abstract

Blockade of voltage-gated sodium channels inhibits invasion of endocrine-resistant breast cancer cells

Fatima H. Mohammed, Maitham A. Khajah, Ming Yang, William J. Brackenbury, Yunus A. Luqmani

View Abstract

Epigenetic induction of epithelial to mesenchymal transition by LCN2 mediates metastasis and tumorigenesis, which is abrogated by NF-κB inhibitor BRM270 in a xenograft model of lung adenocarcinoma

Raj Kumar Mongre, Simrinder Singh Sodhi, Neelesh Sharma, Mrinmoy Ghosh, Jeong Hyun Kim, Nameun Kim, Yang Ho Park, Young Gyu Shin, Sung Jin Kim, Zhang Jiao Jiao, Do Luong Huynh, Dong Kee Jeong

View Abstract

CD44v3+/CD24- cells possess cancer stem cell-like properties in human oral squamous cell carcinoma

Keita Todoroki, Sachiko Ogasawara, Jun Akiba, Masamichi Nakayama, Yoshiki Naito, Naoko Seki, Jingo Kusukawa, Hirohisa Yano

View Abstract

FH535 suppresses the proliferation and motility of hepatocellular carcinoma cells

Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige

View Abstract

Characteristics of carbonic anhydrase 9 expressing cells in human intestinal crypt base

Hidekazu Takahashi, Yozo Suzuki, Junichi Nishimura, Naotsugu Haraguchi, Masahisa Ohtsuka, Susumu Miyazaki, Mamoru Uemura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori

View Abstract

Suppression of hepatocellular carcinoma cell proliferation by short hairpin RNA of frizzled 2 with Sonazoid-enhanced irradiation

Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige

View Abstract

Transcriptome sequencing of human breast cancer reveals aberrant intronic transcription in amplicons and dysregulation of alternative splicing with major therapeutic implications

Shiva Seyed Forootan, Joe M. Butler, Derek Gardener, Alison E. Baird, Andrew Dodson, Alistair Darby, John Kenny, Neil Hall, Andrew R. Cossins, Christopher S. Foster, Christine M. Gosden

View Abstract

A crucial epithelial to mesenchymal transition regulator, Sox4/Ezh2 axis is closely related to the clinical outcome in pancreatic cancer patients

Shinichiro Hasegawa, Hiroaki Nagano, Masamitsu Konno, Hidetoshi Eguchi, Akira Tomokuni, Yoshito Tomimaru, Tadafumi Asaoka, Hiroshi Wada, Naoki Hama, Koichi Kawamoto, Shigeru Marubashi, Naohiro Nishida, Jun Koseki, Masaki Mori, Yuichiro Doki, Hideshi Ishii

View Abstract

Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling

Zhuo Deng, Lijie Wang, Huilian Hou, Jiancheng Zhou, Xu Li

View Abstract

miR-21: A gene of dual regulation in breast cancer

Chunfu Zhang, Kui Liu, Tao Li, Jie Fang, Yanling Ding, Lingxian Sun, Tao Tu, Xinyi Jiang, Shanmei Du, Jiabo Hu, Wei Zhu, Huabiao Chen, Xiaochun Sun

View Abstract

Detection of neuroendocrine tumors using promoter-specific secreted Gaussia luciferase

Alan Wei-Shun Tseng, Victoria Akerstrom, Chiachen Chen, Mary B. Breslin, Michael S. Lan

View Abstract

miR-382 inhibits migration and invasion by targeting ROR1 through regulating EMT in ovarian cancer

Hong Tan, Qingnan He, Guanhui Gong, Yixuan Wang, Juanni Li, Junpu Wang, Ding Zhu, Xiaoying Wu

View Abstract

The impact of CDK9 on radiosensitivity, DNA damage repair and cell cycling of HNSCC cancer cells

Katja Storch, Nils Cordes

View Abstract

TIPE2 functions as a metastasis suppressor via negatively regulating β-catenin through activating GSK3β in gastric cancer

Jie Wu, Haitao Zhang, Chun Xu, Hong Xu, Xiumin Zhou, Yufeng Xie, Min Tao

View Abstract

IL-8 suppresses E-cadherin expression in nasopharyngeal carcinoma cells by enhancing E-cadherin promoter DNA methylation

Rui-Li Zhang, Li-Xia Peng, Jun-Ping Yang, Li-Sheng Zheng, Ping Xie, Meng-Yao Wang, Bi-Jun Huang, Hua-Rong Zhao, Yong-Xing Bao, Chao-Nan Qian

View Abstract

Interleukin-6 stimulates aerobic glycolysis by regulating PFKFB3 at early stage of colorectal cancer

Jun Han, Qingyang Meng, Qiulei Xi, Yongxian Zhang, Qiulin Zhuang, Yusong Han, Yi Jiang, Qiurong Ding, Guohao Wu

View Abstract

NF-κB signaling plays irreplaceable roles in cisplatin-induced bladder cancer chemoresistance and tumor progression

Yi Sun, Zhenfeng Guan, Liang Liang, Yongyi Cheng, Jiancheng Zhou, Jing Li, Yonggang Xu

View Abstract

Combination of Hedgehog inhibitors and standard anticancer agents synergistically prevent osteosarcoma growth

Yoshinobu Saitoh, Takao Setoguchi, Masahito Nagata, Arisa Tsuru, Shunsuke Nakamura, Satoshi Nagano, Yasuhiro Ishidou, Hiroko Nagao-Kitamoto, Masahiro Yokouchi, Shingo Maeda, Akihide Tanimoto, Tatsuhiko Furukawa, Setsuro Komiya

View Abstract

Downregulation of transient receptor potential cation channel, subfamily C, member 1 contributes to drug resistance and high histological grade in ovarian cancer

Xia Liu, Jing Zou, Jie Su, Yi Lu, Jian Zhang, Li Li, Fuqiang Yin

View Abstract

PF-04691502, a dual PI3K/mTOR inhibitor has potent pre-clinical activity by inducing apoptosis and G1 cell cycle arrest in aggressive B-cell non-Hodgkin lymphomas

Deyu Chen, Chaoming Mao, Yuepeng Zhou, Yuting Su, Shenzha Liu, Wen-Qing Qi

View Abstract

Ethanol extract of Kalopanax septemlobus leaf induces caspase-dependent apoptosis associated with activation of AMPK in human hepatocellular carcinoma cells

Cheol Park, Ji-Suk Jeong, Jin-Woo Jeong, Yong-Joo Kim, Yeon-Kwon Jung, Geun-Bae Go, Sung Ok Kim, Gi-Young Kim, Su-Hyun Hong, Young Hyun Yoo, Yung Hyun Choi

View Abstract

CA IX is upregulated in CoCl2-induced hypoxia and associated with cell invasive potential and a poor prognosis of breast cancer

Cheng-Yu Chu, Yi-Ting Jin, Wei Zhang, Juan Yu, Hai-Ping Yang, Hong-Ying Wang, Zi-Jing Zhang, Xiu-Ping Liu, Qiang Zou

View Abstract

Theaflavin-3, 3'-digallate decreases human ovarian carcinoma OVCAR-3 cell-induced angiogenesis via Akt and Notch-1 pathways, not via MAPK pathways

Ying Gao, Gary O. Rankin, Youying Tu, Yi Charlie Chen

View Abstract

Diallyl trisulfide induces apoptosis by suppressing NF-κB signaling through destabilization of TRAF6 in primary effusion lymphoma

Zenpei Shigemi, Yoshiki Furukawa, Kohei Hosokawa, Setsuya Minami, Jumpei Matsuhiro, Shiori Nakata, Tadashi Watanabe, Hiroki Kagawa, Koji Nakagawa, Hiroshi Takeda, Masahiro Fujimuro

View Abstract

Exosomes derived from SW480 colorectal cancer cells promote cell migration in HepG2 hepatocellular cancer cells via the mitogen-activated protein kinase pathway

Mitsuru Chiba, Narumi Watanabe, Miki Watanabe, Maki Sakamoto, Akika Sato, Mizuki Fujisaki, Shiori Kubota, Satoru Monzen, Atsushi Maruyama, Naoki Nanashima, Ikuo Kashiwakura, Toshiya Nakamura

View Abstract

3D matrix-based cell cultures: Automated analysis of tumor cell survival and proliferation

Iris Eke, Stephanie Hehlgans, Veit Sandfort, Nils Cordes

View Abstract

The antipsychotic drug pimozide inhibits cell growth in prostate cancer through suppression of STAT3 activation

Wei Zhou, Ming-Kun Chen, Hao-Tao Yu, Zhi-Hong Zhong, Nan Cai, Guan-Zhong Chen, Ping Zhang, Jia-Jie Chen

View Abstract

Hepatitis B virus X protein activates Notch signaling by its effects on Notch1 and Notch4 in human hepatocellular carcinoma

Juan Gao, Yimin Xiong, Yan Wang, Yiming Wang, Guorong Zheng, Hualin Xu

View Abstract

The effect and mechanism of bufalin on regulating hepatocellular carcinoma cell invasion and metastasis via Wnt/β-catenin signaling pathway

Ji Qin Gai, Xia Sheng, Jian Min Qin, Kang Sun, Wei Zhao, Lei Ni

View Abstract

All-trans retinoic acid inhibits proliferation, migration, invasion and induces differentiation of hepa1-6 cells through reversing EMT in vitro

Jiejie Cui, Mengjia Gong, Yun He, Qilin Li, Tongchuan He, Yang Bi

View Abstract

Overexpression of Tyro3 and its implications on hepatocellular carcinoma progression

Yan Duan, Winnie Wong, Sonja Courtney Chua, Hwee Lin Wee, Seng Gee Lim, Boon Tin Chua, Han Kiat Ho

View Abstract

Differential regulation and synthetic lethality of exclusive RB1 and CDKN2A mutations in lung cancer

Nayoung Kim, Mee Song, Somin Kim, Yujeong Seo, Yonghwan Kim, Sukjoon Yoon

View Abstract

Gambogic acid induces apoptosis and sensitizes TRAIL-mediated apoptosis through downregulation of cFLIPL in renal carcinoma Caki cells

Ji Hoon Jang, Joo-Young Kim, Eon-Gi Sung, Eun-Ae Kim, Tae-Jin Lee

View Abstract

A novel curcumin derivative increases the cytotoxicity of raloxifene in estrogen receptor-negative breast cancer cell lines

Sebastien Taurin, Mhairi Nimick, Lesley Larsen, Rhonda J. Rosengren

View Abstract

Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress

Yoon-Mi Lee, Gibok Lee, Taek-In Oh, Byeong Mo Kim, Do-Wan Shim, Kwang-Ho Lee, Young Jun Kim, Beong Ou Lim, Ji-Hong Lim

View Abstract

Synergistic anticancer effects of cisplatin and histone deacetylase inhibitors (SAHA and TSA) on cholangiocarcinoma cell lines

Md. Ali Asgar, Gulsiri Senawong, Banchob Sripa, Thanaset Senawong

View Abstract

The mechanism of adenosine-mediated activation of lncRNA MEG3 and its antitumor effects in human hepatoma cells

Li-Xuan Liu, Wei Deng, Xiao-Tao Zhou, Rui-Pei Chen, Meng-Qi Xiang, Yi-Tian Guo, Ze-Jin Pu, Rui Li, Ge-Fei Wang, Ling-Fei Wu

View Abstract

OtoRhinoLaryngology & Medicine,New Articles,January 18th,2016

Choroidal thickness changes in obstructive sleep apnea syndrome

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό

Choroidal thickness changes in obstructive sleep apnea syndrome: a systematic review and meta-analysis: Abstract Purpose Obstructive sleep apnea syndrome (OSAS) is a common chronic disorder associated with hypoxia and endothelial and vascular dysfunction. Many studies have analyzed choroidal thickness measurements in patients with different severities of OSAS versus normal subjects by optical coherence tomography (OCT), […]

Does continuous positive airway pressure reduce aldosterone levels in patients with obstructive sleep apnea?

Sheet of osteoblastic cells combined with platelet-rich fibrin improves the formation of bone in critical-size calvarial defects in rabbits

Frenum-like oral synechiae of the lip and vestibule

Cutaneous squamous cell carcinoma of the scalp

Cancer therapeutic doses of bisphosphonates and corticosteroids: Bacterial profile and bone healing

Morphological differentiation of seven parthenogenetic Artemia (Crustacea: Branchiopoda) populations from China, with special emphasis on ploidy degrees

ABSTRACT Parthenogenetic Artemia from seven Chinese locations with different elevations and various ploidies are characterized by phenotypic and morphometric analyses. Our findings show that the studied populations exhibit dissimilar patterns of ovisac. Four phenotypic patterns of furca are qualified and one of them is shared among di-, tetra- and pentaploid Artemia. Results of discriminant analysis […]

Diagnosis of giant cell arteritis: when should we biopsy the temporal artery?

Cutaneous squamous cell carcinoma of the scalp

IL-1β-regulating angiogenic factors expression in perforated temporomandibular disk cells via NF-κB pathway

Children with spinal muscular atrophy type 2 : The sleep patterns

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 λεπτό

Sleep architecture in children with spinal muscular atrophy type 2 via Sleep Medicine [image: S13899457.gif] Publication date: Available online 15 January 2016 *Source:*Sleep Medicine Author(s): Elisabetta Verrillo, Martino Pavone, Oliviero Bruni, Maria Giovanna Paglietti, Raffaele Ferri, Francesca Petreschi, Maria Beatrice Chiarini Testa, Renato Cutrera ObjectiveThere have been few published reports on the sleep patterns of patients with spinal muscular atrophy (SMA) type 2, and none on sleep microstructure. The aim of this study was to analyze sleep architecture and microstructure ... περισσότερα »

CT cephalometric and upper airway measurements in patients with OSA and erectile dysfunction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Computed tomography cephalometric and upper airway measurements in patients with OSA and erectile dysfunction: Abstract PurposeErectile dysfunction (ED) has been linked to obstructive sleep apnea (OSA). This study used computed tomography (CT) to identify cephalometric and upper airway anatomic features in patients with OSA that correlate with the presence of ED. MethodsIn this prospective study, 20 CT cephalometric and upper airway measurements, most commonly associated with OSA, were analyzed in 53 age- and BMI-matched consecutive eligible subjects. Twenty-two were diagnosed ... περισσότερα »

Choroidal thickness changes in obstructive sleep apnea syndrome

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Choroidal thickness changes in obstructive sleep apnea syndrome: a systematic review and meta-analysis: Abstract PurposeObstructive sleep apnea syndrome (OSAS) is a common chronic disorder associated with hypoxia and endothelial and vascular dysfunction. Many studies have analyzed choroidal thickness measurements in patients with different severities of OSAS versus normal subjects by optical coherence tomography (OCT), but the results have been inconsistent. Therefore, a meta-analysis was performed to evaluate the choroidal thickness changes in OSAS measured by OCT. MethodsPer... περισσότερα »

Does continuous positive airway pressure reduce aldosterone levels in patients with obstructive sleep apnea?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Does continuous positive airway pressure reduce aldosterone levels in patients with obstructive sleep apnea?: Abstract PurposeAldosterone is associated with the development of obstructive sleep apnea (OSA) and cardiovascular diseases. Continuous positive airway pressure (CPAP) is an effective treatment for OSA, but the impact of CPAP therapy on aldosterone levels in patients with OSA remains unclear. To address this issue, a meta-analysis was conducted to evaluate the effects of CPAP therapy on serum aldosterone levels in OSA. MethodsTwo reviewers independently searched PubMed,... περισσότερα »

Sheet of osteoblastic cells combined with platelet-rich fibrin improves the formation of bone in critical-size calvarial defects in rabbits

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Sheet of osteoblastic cells combined with platelet-rich fibrin improves the formation of bone in critical-size calvarial defects in rabbits: Techniques that use sheets of cells have been successfully used in various types of tissue regeneration, and platelet-rich fibrin (PRF) can be used as a source of growth factors to promote angiogenesis. We have investigated the effects of the combination of PRF and sheets of mesenchymal stem cells (MSC) from bone marrow on the restoration of bone in critical-size calvarial defects in rabbits to find out whether the combination promotes bony heal... περισσότερα »

Frenum-like oral synechiae of the lip and vestibule

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Frenum-like oral synechiae of the lip and vestibule: AbstractTwo cases where aberrant tissue was attached to the lower lip mimicking the inferior labial frenum were reported. The frenum-like tissue extended from the gingival margin between the lower left deciduous central and lateral incisors in case 1 and between the lower right deciduous central and lateral incisors in case 2, to the dry lower lip. Histologically, the resected specimen was regarded as normal oral mucosa covered with stratified squamous epithelium, without a clear amniotic band. The frenum-like tissue of the lower... περισσότερα »

Cutaneous squamous cell carcinoma of the scalp

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Cutaneous squamous cell carcinoma of the scalp in the immunocompromised patient: review of 53 cases: Abstract ObjectiveWe analyzed outcomes from immunocompromised patients with scalp squamous cell carcinoma (SCC) treated with surgical excision with and without radiation in order to explore 3-year disease-free survival and overall survival. Study designThe study design was a retrospective chart review. SettingThis study was conducted in a private practice setting. Subjects and methodsThe study included 53 immunocompromised patients with an average age of 63.2 years, with ...περισσότερα »

Cancer therapeutic doses of bisphosphonates and corticosteroids: Bacterial profile and bone healing

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Bacterial profile and bone healing in rats receiving cancer therapeutic doses of bisphosphonates and corticosteroids: a pilot study via Oral and Maxillofacial Surgery Publication date: Available online 15 January 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): Z. Jabbour, C. do Nascimento, M. El-Hakim, J.E. Henderson, R.F. de Albuquerque Junior The microbial aetiology of bisphosphonate-related osteonecrosis of the jaw (BRONJ) remains undefined. This study investigated the oral microbiota and socket healing after zoledronic acid (ZA) and dexamethasone (D... περισσότερα »

Morphological differentiation of seven parthenogenetic Artemia (Crustacea: Branchiopoda) populations from China, with special emphasis on ploidy degrees

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα

Only patients with BP below 160/100 should be referred for surgery to avoid cancellations, guidelines say

GPs should include information on a patient’s blood pressure (BP) in referral letters for elective surgery and should refer only those with BP lower than 160/100 mm Hg over the previous 12 months,… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1KlSIeT via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

New bowel cancer screening test is recommended for England

A simpler, more sensitive home screening test for bowel cancer has been recommended for use in the NHS bowel cancer screening programme in England.The UK National Screening Committee has recommended… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Sr8htE via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

WHAT’S UP DOC? What is the treatment for thyroid cancer? – Wicked Local Walpole

WHAT’S UP DOC? What is the treatment for thyroid cancer? Wicked Local Walpole Q: My friend was diagnosed with thyroid cancer and has to get radioactive iodine treatment. What can you tell me about this? A: The thyroid is a butterfly-shaped gland in the front of the lower neck which makes thyroid hormone. Cancer of […]

Cancer-surviving mom stays strong for her son – Asbury Park Press

Asbury Park Press Cancer-surviving mom stays strong for her son Asbury Park Press This time last year I was living in North Jersey and gearing up for radioactive iodine therapy to coincide with my thyroid cancer treatment plan. These days, I see my doctors every few months for bloodwork and scans to make sure there […]

【News Release】Toshiba Medical Systems Corporation to Bring Leading-edge Medical Diagnostic Imaging Systems to Arab Health 2016

from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SXM2e5 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Cough suppressant

Cough suppressant: A drug used to control coughing, particularly with a dry, nagging, unproductive cough. MedTerms (TM) is the Medical Dictionary of MedicineNet.com. We Bring Doctors’ Knowledge To You from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SXI7xZ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Vice President Joe Biden fitting choice to lead charge against cancer – Bradenton Herald

Vice President Joe Biden fitting choice to lead charge against cancer Bradenton Herald But, ominously, some cancers still are on the rise, including certain types of leukemia and cancers of the tongue, tonsil, small intestine, liver, pancreas, kidney and thyroid. Researchers say they are poised to make dramatic new advances in the coming … and […]

Musashi2 as a novel predictive biomarker for liver metastasis and poor prognosis in colorectal cancer

Abstract Aberrant expression of musashi2 (MSI-2) has been detected in several malignancies. However, its role in the progression of colorectal cancer (CRC) remains unknown. Our study was designed to investigate the expression and prognostic significance of MSI-2 protein in patients with colorectal cancer. The expression of MSI-2 was detected in 164 patients’ colorectal cancer and […]

Development and characterization of two human triple-negative breast cancer cell lines with highly tumorigenic and metastatic capabilities

Abstract Triple-negative breast cancer (TNBC) is a group of cancer with high diversity, limited therapies, and poor prognosis. TNBC cell lines and animal models provide effective tools for studies and drug discovery. Here, we report the development of two TNBC cell lines (XtMCF and LmMCF) based on our existing cell model that consists of normal […]

Diagnosis of giant cell arteritis: when should we biopsy the temporal artery?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα

Diagnosis of giant cell arteritis: when should we biopsy the temporal artery? Abstract Giant cell arteritis (GCA) can be diagnosed histopathologically by biopsy of the temporal artery, and clinically using the 5-point score of the 1990 American College of Rheumatology (ACR) classification. We aimed to find out whether some patients are referred for biopsy unnecessarily. We audited all referrals (n = 100) made to the Department of Oral and Maxillofacial Surgery over 34 months, and used the ACR classification to find out whether patients had had a clinical diagnosis of GCA at refer... περισσότερα »

Cutaneous squamous cell carcinoma of the scalp

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα

IL-1β-regulating angiogenic factors expression in perforated temporomandibular disk cells via NF-κB pathway

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα

IL-1β-regulating angiogenic factors expression in perforated temporomandibular disk cells via NF-κB pathway: Background A high density of blood vessels is observed in the perforated disks of temporomandibular joint (TMJ), but the underlying mechanism is unknown. This study aimed to explore the regulation of disk angiogenesis in the perforated disks. Methods Expressions of vascular endothelial growth factor (VEGF), angiogenin-1 (Ang-1), chondromodulin-1 (ChM-1), and thrombospondins-1 (TSP-1) were compared between healthy and perforated TMJ disk cells with or without interleukin-1β (...περισσότερα »

Overexpression of Bcl-2, SOCS 1, 3 and Cdh 1, 2 are associated with the early neoplasic changes in modified 4-nitroquinoline 1-oxide-induced murine oral cancer model

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα

Overexpression of Bcl-2, SOCS 1, 3 and Cdh 1, 2 are associated with the early neoplasic changes in modified 4-nitroquinoline 1-oxide-induced murine oral cancer model: Background The objective was to assess histopathological changes and the expression of proliferating cell nuclear antigen (PCNA), Bcl-2, suppressor of cytokine signaling (SOCS) 1 and 3, Vimentin, TWIST1, and Cdh 1 and 2 in early stages of experimental oral carcinogenesis process using a shorter period of exposure to 4-nitroquinoline oxide (4-NQO) model. Methods In this study, 20 rats were divided into control group (*n... περισσότερα »

The Akt/mTOR pathway is activated in verrucous carcinoma of the oral cavity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα

The Akt/mTOR pathway is activated in verrucous carcinoma of the oral cavity: Background The Akt/mTOR pathway is activated in many malignancies, including oral squamous cell carcinoma (OSCC). However, the role of the Akt/mTOR pathway in oral verrucous carcinoma (OVC), a low-grade variant of OSCC, remains unknown. Thus, the objective of this study was to investigate the activation level of important markers of the Akt/mTOR pathway in OVC and to compare the results with OSCC samples. Methods The expression of p-Akt (Thr308), p-Akt (Ser473), and p-RPS6 was evaluated by immunohistochemi... περισσότερα »

Initial Results With Image-guided Cochlear Implant Programming in Children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα

*Initial Results With Image-guided Cochlear Implant Programming in Children: [image: image]Hypothesis: Image-guided cochlear implant (CI) programming can improve hearing outcomes for pediatric CI recipients. Background: CIs have been highly successful for children with severe-to-profound hearing loss, offering potential for mainstreamed education and auditory-oral communication. Despite this, a significant number of recipients still experience poor speech understanding, language delay, and, even among the best performers, restoration to normal auditory fidelity is rare. Although... περισσότερα »

The Etiology of Patients Receiving Cochlear Implantation With Special Emphasis on Genetic Epidemiology

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα

A Comprehensive Study on by Miyagawa, Maiko; Nishio, Shin-Ya; Usami, Shin-Ichi via Otology & Neurotology Current Issue [image: image]Objective: Cochlear implantation is the most important treatment currently available for profound sensorineural hearing loss. The aim of this study was to investigate the etiology of hearing loss in patients with cochlear implantation, and to compare outcomes. Methods: Japanese hearing loss patients who received cochlear implants (CIs) or electric acoustic stimulation (EAS) in Shinshu University hospital (n = 173, prelingual onset: 92, postlingual onse...περισσότερα »

GJB2 Mutations in Hearing Impaired Patients

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα

Prevalence and Audiological Profiles of GJB2 Mutations in a Large Collective of Hearing Impaired Patients via Hearing Research Publication date: Available online 15 January 2016 *Source:*Hearing Research Author(s): W.F. Burke, A. Warnecke, A. Schöner-Heinisch, A. Lesinski-Schiedat, H. Maier, T. Lenarz Mutations in the GJB2 gene are known to represent the commonest cause of hereditary and congenital hearing loss. In this study, a complete sequencing of the GJB2 gene in a cohort of 506 patients from a single, large cochlear implant program in Europe was performed. Audiological testing f... περισσότερα »

Temperature Sensitive Auditory Neuropathy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Temperature Sensitive Auditory Neuropathy via Hearing Research Publication date: Available online 15 January 2016 *Source:*Hearing Research Author(s): Qiujing Zhang, Lan Lan, Wei Shi, Lan Yu, Lin-yi Xie, Fen Xiong, Cui Zhao, Na Li, Zifang Yin, Liang Zong, Jing Guan, Dayong Wang, Wei Sun, Qiuju Wang Temperature sensitive auditory neuropathy is a very rare and puzzling disorder. In the present study, we reported three unrelated 2 to 6 year-old children who were diagnosed as auditory neuropathy patients who complained of severe hearing loss when they had fever. Their hearing thresholds va... περισσότερα »

Auditory intensity processing: Effect of MRI background noise

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Auditory intensity processing: Effect of MRI background noise via Hearing Research Publication date: Available online 15 January 2016 *Source:*Hearing Research Author(s): Nicole Angenstein, Jörg Stadler, André Brechmann Studies on active auditory intensity discrimination in humans showed equivocal results regarding the lateralization of processing. Whereas experiments with a moderate background found evidence for right lateralized processing of intensity, functional magnetic resonance imaging (fMRI) studies with background scanner noise suggest more left lateralized processing. With th...περισσότερα »

Language, Speech, and Hearing Services in Schools Online First

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Factors Affecting Early Services for Children Who Are Hard of Hearing Purpose To describe factors affecting early intervention (EI) for children who are hard of hearing, we analyzed (a) service setting(s) and the relationship of setting to families' frequency of participation, and (b) provider preparation, caseload composition, and experience in relation to comfort with skills that support spoken language for children who are deaf and hard of hearing (CDHH). Method Participants included 122 EI professionals who completed an online questionnaire annually and 131 parents who participate... περισσότερα »

Vocal nodules in school age children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Vocal nodules in school age children via Logopedia, Foniatría y Audiología Publication date: Available online 15 January 2016 *Source:*Revista de Logopedia, Foniatría y Audiología Author(s): Janete Coelho, Daniela Ramos, Isabel Monteiro, António Diogo Paiva IntroductionVocal nodules are the most common organic and functional lesions among the paediatrics population, being the main cause of dysphonia during childhood. In Portugal, a few studies that describe the vocal parameters in school age children with this pathology were found. The objective of this paper is to analyse the percept...περισσότερα »

【News Release】Toshiba Medical Systems Corporation to Bring Leading-edge Medical Diagnostic Imaging Systems to Arab Health 2016

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SXM2e5 via IFTTT

Gait & Posture

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα

Biomechanical and perceived differences between overground and treadmill walking in children with cerebral palsy Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Taeyou Jung, Yumi Kim, Luke E. Kelly, Mark F. Abel The treadmill is widely used as an instrument for gait training and analysis. The primary purpose of this study was to compare biomechanical variables between overground and treadmill walking in children with cerebral palsy (CP). Perceived differences between the two walking modes were also investigated by comparing self-selected walking speeds....περισσότερα »

Revista de Logopedia, Foniatría y Audiología

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα

The effect of SpeechEasy® on attitudes, emotions and coping behaviors. Outcomes of short time usage Publication date: Available online 17 January 2016 *Source:*Revista de Logopedia, Foniatría y Audiología Author(s): Mônica de Britto Pereira, John Van Borsel This study investigated the effect of SpeechEasy® on attitudes, emotions and coping behaviors after a short period of usage. Nine individuals who stutter were fitted with the SpeechEasy® and used the device for at least 4h/day during a period of less than 2 months. Before and after this period spontaneous speech samples were colle... περισσότερα »

Immunologic Responses in HPV-Associated Carcinoma for Patients Receiving Chemoradiation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα

Immunologic Responses in HPV-Associated Carcinoma for Patients Receiving Chemoradiation: *Conditions*: Head and Neck Cancer; HPV (Human Papillomavirus)-Associated Carcinoma; Oropharyngeal *Intervention*: Other: research blood draw and tissue biopsy *Sponsors*: Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute (NCI) The primary purpose of this research is to investigate anti-tumor immune responses in patients undergoing chemotherapy and radiation for Head and Neck Cancers. Hypothesis: Treatment of HPV-associated OPSCC with concurrent chemoradiation r... περισσότερα »

HNSCCs : Biological Vaccine: Semi-allogeneic Human Fibroblasts (MRC-5) Transfected With DNA

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα

Biological Vaccine: Semi-allogeneic Human Fibroblasts (MRC-5) Transfected With DNA: *Condition*: Head and Neck Squamous Cell Carcinoma (HNSCC) *Intervention*: Biological: Semi-allogenic human fibroblast (MRC-5) transfected with DNA *Sponsors*: Robert Ferris; Immune Cell Therapy Inc. Hypothesis The incidence of toxicity in patients receiving the tumor DNA-transfected fibroblast vaccine will be acceptably low and the immunologic response rate sufficiently high to warrant further study of this therapy The study of the vaccine will proceed in two stages after the method of Si...περισσότερα »

Lenvatinib for the Treatment of Anaplastic Thyroid Cancer (ATC)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα

A Phase 2 Trial of Lenvatinib for the Treatment of Anaplastic Thyroid Cancer (ATC): *Condition*: Thyroid Cancer, Anaplastic *Intervention*: Drug: Lenvatinib 24 mg *Sponsor*: Eisai Inc. ArmsAssigned InterventionsExperimental: Lenvatinib Participants will receive lenvatinib 24 milligrams (mg) (2 capsules of 10 mg each and 1 capsule of 4 mg) once daily by oral administration for up to approximately 24 months. Drug: Lenvatinib 24 mg Other Names: - Lenvima - E7080

The alveolar bone regeneration with the secretome from human mesenchymal stem cells

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα

First-in-human study and clinical case reports of the alveolar bone regeneration with the secretome from human mesenchymal stem cells: Abstract BackgroundSecreted growth factors and cytokines in the conditioned medium from bone marrow-derived mesenchymal stem cells (MSC-CM) have several effects on cell behavior. Our previous studies revealed that MSC-CM enhances bone regeneration by increasing cell mobilization, angiogenesis, and osteogenesis in vitro and in vivo. This clinical study was undertaken to evaluate the safety and use of MSC-CM for alveolar bone regeneration in eight pa...περισσότερα »

HNCs : Pretreatment screening for distant metastases

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα

Pretreatment screening for distant metastases in the Dutch head and neck centers: 10 years later: AbstractTo evaluate the current practice and change in practice concerning screening for distant metastases in head and neck squamous cell carcinoma patients, we performed a survey with the same questionnaire as 10 years ago among the eight centers of the Dutch Head and Neck Society treating head and neck cancer in The Netherlands. Factors related to extensive lymph node metastases are the most frequent indication for screening for distant metastases. The combinations of whole body PET...περισσότερα »

How Should We Consider the Risk of Antineutrophil Cytoplasmic Antibody (ANCA)–Positive Small-Vessel Vasculitis Associated with Antithyroid Drug Therapy?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα

How Should We Consider the Risk of Antineutrophil Cytoplasmic Antibody (ANCA)–Positive Small-Vessel Vasculitis Associated with Antithyroid Drug Therapy?: Clinical Thyroidology Jan 2016, Vol. 28, No. 1: 18-21. - Full Text HTML - Full Text PDF (223.4 KB) - Full Text PDF with Links (225.7 KB) Author information Jacques Orgiazzi Balavoine AS, Glinoer D, Dubucquoi S, Wémeau JL. Antineutrophil cytoplasmic antibody-positive small-vessel vasculitis associated with antithyroid drug therapy: how significant is the clinical problem? Thyroid 2015;25:1273-81. Epub October 19 201... περισσότερα »

Severe Gestational Hyperthyroidism Can Be Due to a Mutant TSH Receptor with Enhanced Sensitivity to HCG

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα

Severe Gestational Hyperthyroidism Can Be Due to a Mutant TSH Receptor with Enhanced Sensitivity to HCG: Clinical Thyroidology Jan 2016, Vol. 28, No. 1: 9-10. - Full Text HTML - Full Text PDF (182 KB) - Full Text PDF with Links (183 KB) Author information Jerome M. Hershman Coulon AL, Savagner F, Briet C, Vernin M, Munier M, Chabre O, Rodien P. Prolonged and severe gestational thyrotoxicosis due to enhanced hCG sensitivity of a mutant thyrotropin receptor. J Clin Endocrinol Metab. November 18, 2015:jc20153670 [Epub ahead of print].

Which Patients with Diabetes Should Be Routinely Screened for Thyroid Diseases?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα

Which Patients with Diabetes Should Be Routinely Screened for Thyroid Diseases?: Clinical Thyroidology Jan 2016, Vol. 28, No. 1: 2-5. - Full Text HTML - Full Text PDF (224.2 KB) - Full Text PDF with Links (225.1 KB) Author information Stephen W. Spaulding Fleiner HF, Bjøro T, Midthjell K, Grill V, Åsvold BO. Prevalence of thyroid dysfunction in autoimmune and type 2 diabetes: the population-based HUNT Study in Norway. J Clin Endocrinol Metab. November 19, 2015 [Epub ahead of print]. [image: Free first page]

TSH-Receptor Antibodies Decline with a Half-Life of Several Months after Thyroidectomy For Graves’ Disease

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα

TSH-Receptor Antibodies Decline with a Half-Life of Several Months after Thyroidectomy For Graves’ Disease: Clinical Thyroidology Jan 2016, Vol. 28, No. 1: 16-17. - Full Text HTML - Full Text PDF (180.8 KB) - Full Text PDF with Links (183 KB) Author information Jerome M. Hershman Yoshioka W, Miyauchi A, Ito M, Kudo T, Tamai H, Nishihara E, Kihara M, Miya A, Amino N. Kinetic analyses of changes in serum TSH receptor antibody values after total thyroidectomy in patients with Graves’ disease. Endocr J. December 3, 2015 [Epub ahead of print].

Decreased Maternal Iodine Nutritional Status Before and During Pregnancy Adversely Impacts Offspring IQ at 6 to 12 Years of Age

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα

Decreased Maternal Iodine Nutritional Status Before and During Pregnancy Adversely Impacts Offspring IQ at 6 to 12 Years of Age: Clinical Thyroidology Jan 2016, Vol. 28, No. 1: 14-15. - Full Text HTML - Full Text PDF (181.6 KB) - Full Text PDF with Links (182.6 KB) Author information Angela M. Leung Moleti M, Trimarchi F, Tortorella G, Longo AC, Giorgianni G, Sturniolo G, Alibrandi A, Vermiglio F. Effects of maternal iodine nutrition and thyroid status on cognitive development in offspring: a pilot study. Thyroid. November 20, 2015 (Epub ahead of print).

Maternal Hypothyroxinemia, but not Subclinical Hypothyroidism, Is Associated with Increased Body Weight, Triglycerides, and Insulin Resistance

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα

Maternal Hypothyroxinemia, but not Subclinical Hypothyroidism, Is Associated with Increased Body Weight, Triglycerides, and Insulin Resistance: Clinical Thyroidology Jan 2016, Vol. 28, No. 1: 11-13. Author information Elizabeth N. Pearce Knight BA, Shields BM, Hattersley AT, Vaidya B. Maternal hypothyroxinaemia in pregnancy is associated with obesity and adverse maternal metabolic parameters. Eur J Endocrinol 2016;174:51-7. [image: Free first page]

Perchlorate Is Negatively Associated with Maternal Thyroid Function during Pregnancy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα

Perchlorate Is Negatively Associated with Maternal Thyroid Function during Pregnancy: Clinical Thyroidology Jan 2016, Vol. 28, No. 1: 6-8. - Full Text HTML - Full Text PDF (256.1 KB) - Full Text PDF with Links (219.1 KB) Author information Tim I.M. Korevaar Steinmaus C, Pearl M, Kharrazi M, Blount BC, Miller MD, Pearce EN, Valentin-Blasini L, DeLorenze G, Hoofnagle AN, Liaw J. Thyroid hormones and moderate exposure to perchlorate during pregnancy in women in Southern California. Environ Health Perspect. October 20, 2015 [Epub ahead of print]. [image: Free first page]

Unmet Information Needs of Low-Risk Thyroid Cancer Survivors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα

Unmet Information Needs of Low-Risk Thyroid Cancer Survivors: Thyroid , Vol. 0, No. 0. - Full Text HTML - Full Text PDF (51.6 KB) - Full Text PDF with Links (56.7 KB) Author information Anna M. Sawka,1 James D. Brierley,2 Richard W. Tsang,2 Lorne Rotstein,3 Shereen Ezzat,1 and David P. Goldstein4 1Division of Endocrinology, Department of Medicine, University Health Network and University of Toronto, Toronto,Canada. 2Department of Radiation Oncology, Princess Margaret Hospital (University Health Network) and University of Toronto, Toronto, Canada. 3Department of Surge...περισσότερα »

Parathyroid carcinoma.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα

Parathyroid carcinoma.: Purpose of review: This article highlights recent advances in our understanding of the incidence, epidemiology, clinical presentation, evaluation, diagnosis, treatment, and prognosis of parathyroid carcinoma. Recent findings: The prevalence of parathyroid carcinoma is approximately 0.005% of all cancers. Therefore, parathyroid carcinoma is one of the rarest malignancies known. Patients with parathyroid carcinoma present with clinical symptoms of hypercalcaemia as these cancers are usually hormonally functional. It is not uncommon that patients present with com...περισσότερα »

Candida krusei and Candida glabrata on Candida albicans gene expression

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα

Influence of Candida krusei and Candida glabrata on Candida albicans gene expression in in vitro biofilms via Oral Biology Publication date: Available online 15 January 2016 *Source:*Archives of Oral Biology Author(s): Patrícia Pimentel Barros, Felipe Ribeiro Camargo, Rodnei Dennis Rossoni, Juliana Campos Junqueira, Antonio Olavo Cardoso Jorge ObjectiveThe present study aimed to evaluate the interactions between the species Candida albicans, Candida krusei and Candida glabrata in monotypic and mixed biofilm models formed in vitro as well as the relative expression of the ALS1, ALS3, HW...περισσότερα »

Vestibular results after intratympanic gentamicin therapy in disabling Menière’s disease

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα

Vestibular results after intratympanic gentamicin therapy in disabling Menière’s disease: AbstractIntratympanic injection of gentamicin is increasingly used in the treatment of unilateral disabling Menière’s disease (MD). Several objective functional and subjective tests have been developed to assess the control of vertigo after gentamicin treatment. The aim of this study was to show that subjective results require a vestibular deafferentation as profound as possible, evidenced with multifrequency vestibular assessment. Sixty four patients with intractable MD in situation of medica... περισσότερα »

Carotid dissection and cerebral infarction are extremely rare complications of adenoidectomy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα

Carotid artery dissection following adenoidectomy via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 16 January 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Arun garg, Yeeshu Singh, Pankaj Singh, Gaurav goyal, Sushant Bhuyan Carotid dissection and cerebral infarction are extremely rare complications of adenoidectomy. We describe the case of seven year old girl, who suffered from left internal carotid artery dissection following adenoidectomy, leading to right hemiplegia with global aphasia. A CT angiogram conf... περισσότερα »

Chronic Daily Headache: Mechanisms and Principles of Management

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα

Chronic Daily Headache: Mechanisms and Principles of Management: AbstractPrimary headache is a common malady that is often under-recognized and frequently inadequately managed in spite of the fact that it affects up to 95 % of the population in a lifetime. Many forms of headache, including episodic tension and migraine headaches, if properly diagnosed, are reasonably amenable to treatment, but a smaller, though not insignificant, percent of the population suffer daily from a chronic, intractable form of headache that destroys one’s productivity and quality of life. These patients a... περισσότερα »

Confocal microscopy for the oral cavity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα

In vivo confocal microscopy for the oral cavity: Current state of the field and future potential via ScienceDirect Publication: Oral Oncology Publication date: Available online 16 January 2016 *Source:*Oral Oncology Author(s): N.G. Maher, H. Collgros, P. Uribe, S. Ch’ng, M. Rajadhyaksha, P. Guitera Confocal microscopy (CM) has been shown to correlate with oral mucosal histopathology in vivo. The purposes of this review are to summarize what we know so far about in vivo CM applications for oral mucosal pathologies, to highlight some current developments with CM devices relevant for oral...περισσότερα »

Sinonasal Globular Amyloidosis Simulating Malignancy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα

Sinonasal Globular Amyloidosis Simulating Malignancy: A Rare Presentation: AbstractPrimary localized amyloidosis in the head and neck region is a rare entity. The most commonly involved organ is larynx. Primary amyloidosis localized to the sinonasal tract is extremely rare. We report one such case along with a brief review of the associated literature. The aim of reporting this case is to emphasize the fact that sometimes nasal amyloidosis can also present with signs and symptoms of nasal and nasopharyngeal malignancy. The definitive diagnosis in such cases depends upon histopathol... περισσότερα »

Stem cell approaches for vocal fold regeneration

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα

Stem cell approaches for vocal fold regeneration: Objectives/Hypothesis Current interventions in the management of vocal fold (VF) dysfunction focus on conservative and surgical approaches. However, the complex structure and precise biomechanical properties of the human VF mean that these strategies have their limitations in clinical practice and in some cases offer inadequate levels of success. Regenerative medicine is an exciting development in this field and has the potential to further enhance VF recovery beyond conventional treatments. Our aim in this review is to discuss advan...περισσότερα »

Quality of life after intervention with a cochlear implant or hearing aid

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα

Quality of life after intervention with a cochlear implant or hearing aid: Objectives/Hypothesis To investigate the impact of hearing aid and cochlear implant use on quality of life in adults. Study Design Prospective observational cohort study. Methods One hundred thirteen adults aged ≥50 years with postlingual hearing loss receiving routine clinical care at a tertiary academic medical center were evaluated with the Medical Outcome Study Short Form-36 before and 6 and 12 months after intervention with hearing aids or cochlear implants. Change in score was assessed using linear mixed... περισσότερα »

The cause of brachial plexopathy in robot-assisted transaxillary thyroidectomy—A neurophysiological investigation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα

The cause of brachial plexopathy in robot-assisted transaxillary thyroidectomy—A neurophysiological investigation: Objectives/Hypothesis During robot-assisted transaxillary thyroidectomy, the patient's arm is maintained in an overhead flexed position for a prolonged time, which poses a risk of postoperative brachial plexopathy. The aim of the study was to identify the causes of brachial plexopathy and to assess the benefit of intraoperative neurophysiological monitoring (IONM) in preventing positional brachial plexopathy in this setting. Study Design Retrospective case series. Metho... περισσότερα »

Congenital oval or round window malformations in children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα

Congenital oval or round window malformations in children: Surgical findings and results in 17 cases: Objectives/Hypothesis To prospectively evaluate surgical findings and hearing results in children undergoing surgery for congenital oval or round window malformations (class IV malformations). Study Design A nonrandomized, nonblinded, case series of prospectively collected data. Methods Fourteen consecutive pediatric patients who underwent 17 surgical procedures for congenital oval or round window malformations in a tertiary referral center were included. Postoperative pure-tone audi... περισσότερα »

Audiologic limitations of Vibrant Soundbridge device: Is the contralateral hearing aid fitting indispensable?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα

Audiologic limitations of Vibrant Soundbridge device: Is the contralateral hearing aid fitting indispensable?: Objectives/Hypothesis The purpose of this study was to evaluate the audiologic limitations of the Vibrant Soundbridge (VSB) implant and the benefits of contralateral hearing aid (HA) fitting in VSB recipients. Study Design Retrospective study. Methods Twenty-three patients with symmetrical sensorineural or mixed hearing loss were enrolled in this study. The patients underwent VSB implantation in one ear and HA fitting in the other. Aided pure-tone audiometry was performed t...περισσότερα »

Assessment of pediatric obstructive sleep apnea using a drug-induced sleep endoscopy rating scale

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα

Assessment of pediatric obstructive sleep apnea using a drug-induced sleep endoscopy rating scale: Objectives/Hypothesis Assess the reliability of a Sleep Endoscopy Rating Scale (SERS) and its relationship with pediatric obstructive sleep apnea (OSA) severity. Study Design Retrospective case series of pediatric patients who underwent drug-induced sleep endoscopy (DISE) at the time of surgery for OSA from January 1, 2013 to May 1, 2014. Methods Three blinded otolaryngologists scored obstruction on DISE recordings as absent (0), partial (+1), or complete (+2) at six anatomic levels: na... περισσότερα »

Audible sphenoid-sellar fistula: An unusual complication of transphenoidal surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα

Audible sphenoid-sellar fistula: An unusual complication of transphenoidal surgery: Eustachian tube problems are relatively common complaints to otolaryngologists' offices. However, clinicians should consider other possibilities when traditional therapies fail to improve symptoms. We present a previously not described case of sphenoid-sellar fistula after transphenoidal surgery causing objective and subjective clicking. Level of Evidence NA *Laryngoscope*, 2015

Facial nerve palsy, parotid gland enlargement, anterior uveitis, and low grade fever : Heerfordt’s Syndrome: A Rare Manifestation of Sarcoidosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα

Two Cases of Heerfordt’s Syndrome: A Rare Manifestation of Sarcoidosis: Heerfordt’s syndrome is a rare manifestation of sarcoidosis characterized by the presence of facial nerve palsy, parotid gland enlargement, anterior uveitis, and low grade fever. Two cases of Heerfordt’s syndrome and a literature review are presented. Case 1. A 53-year-old man presented with swelling of his right eyelid, right facial nerve palsy, and swelling of his right parotid gland. A biopsy specimen from the swollen eyelid indicated sarcoidosis and he was diagnosed with incomplete Heerfordt’s syndrome based ... περισσότερα »

The Akt/mTOR pathway is activated in verrucous carcinoma of the oral cavity

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 43 δευτερόλεπτα

Background The Akt/mTOR pathway is activated in many malignancies, including oral squamous cell carcinoma (OSCC). However, the role of the Akt/mTOR pathway in oral verrucous carcinoma (OVC), a low-grade variant of OSCC, remains unknown. Thus, the objective of this study was to investigate the activation level of important markers of the Akt/mTOR pathway in OVC and to compare the results with OSCC samples. Methods The expression of p-Akt (Thr308), p-Akt (Ser473), and p-RPS6 was evaluated by immunohistochemistry in 30 OSCC cases, 18 OVC cases, and 30 control cases (normal epitheli... περισσότερα »

Circulating dentinal antigen-antibody immune complexes during orthodontic tooth movement in rats

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 43 δευτερόλεπτα

Background The immunogenic potential of dentin has been reported through dentin-reactive autoantibodies detection in human and animal model. This study aimed to investigate the formation and diagnostic value of immune complexes formation after autoantibodies production, and soluble dentin antigens levels associated to root resorption, in the course of orthodontic tooth movement, in rat experimental model. Methods Forty Wistar rats (*n* = 8 for each group) were submitted to orthodontic tooth movement, in which the maxillary right first molar was mesially moved by applying of 55 g...περισσότερα »

Cough suppressant

Cough suppressant: A drug used to control coughing, particularly with a dry, nagging, unproductive cough. MedTerms (TM) is the Medical Dictionary of MedicineNet.com. We Bring Doctors’ Knowledge To You from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SXI7xZ via IFTTT

Vice President Joe Biden fitting choice to lead charge against cancer – Bradenton Herald

Musashi2 as a novel predictive biomarker for liver metastasis and poor prognosis in colorectal cancer

Development and characterization of two human triple-negative breast cancer cell lines with highly tumorigenic and metastatic capabilities

Expression of aurora kinase A correlates with the Wnt-modulator RACGAP1 in gastric cancer

Abstract Canonical Wnt signaling is involved in gastric carcinogenesis. The aim of this study was to identify the link between Wnt signaling and aurora kinase A (AURKA), a target for the treatment of gastrointestinal cancers. Publicly available microarray data were used to identify phenotype-specific protein–protein interaction (PPI) subnetworks. The in silico analysis revealed a gastric […]

Characterization of copy number alterations in a mouse model of fibrosis-associated hepatocellular carcinoma reveals concordance with human disease

Abstract Hepatocellular carcinoma (HCC) is a prevalent human cancer with rising incidence worldwide. Human HCC is frequently associated with chronic liver inflammation and cirrhosis, pathophysiological processes that are a consequence of chronic viral infection, disturbances in metabolism, or exposure to chemical toxicants. To better characterize the pathogenesis of HCC, we used a human disease-relevant mouse […]

Nimotuzumab enhances temozolomide-induced growth suppression of glioma cells expressing mutant EGFR in vivo

Abstract A mutant form of epidermal growth factor receptor (EGFR), EGFRvIII, is common in glioblastoma (GBM) and confers enhanced tumorigenic activity and drug resistance. Nimotuzumab, an anti-EGFR antibody, has shown preclinical and clinical activity to GBM, but its specific activity against EGFRvIII has not been fully investigated. Human glioma U87MG or LNZ308 cells overexpressing either […]

Triage of patients with AUS/FLUS on thyroid cytopathology: effectiveness of the multimodal diagnostic techniques

Abstract The management of patients with thyroid cytopathologic diagnosis of atypia (or follicular lesion) of undetermined significance (AUS/FLUS) is a complex clinical problem. The purpose of this study was to develop a practical triage scheme based on multiple diagnostic tests in general use. We performed a retrospective cohort study involving 15,335 consecutive patients with a […]

Local woman advocates for Death with Dignity bill – Frederick News Post (subscription)

Frederick News Post (subscription) Local woman advocates for Death with Dignity bill Frederick News Post (subscription) For the last 23 years, Lloyd said her day-to-day life has been a mix of ongoing tests, chemotherapy, surgeries and doctors visits. She’s had 16 surgeries in that time, she said. Her larynx was removed after her throat cancer […]

The Akt/mTOR pathway is activated in verrucous carcinoma of the oral cavity

The Hyperactivity of Efferent Auditory System in Patients with Schizophrenia: A Transient Evoked Otoacoustic Emissions Study.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 56 δευτερόλεπτα

CONCLUSION: The present findings suggest increased inhibitory effect of efferent auditory pathway especially on the right cochlear outer hair cells. Further studies to investigate increased suppressive effects are crucial to expand the current understanding of auditory hallucination mechanisms in schizophrenia patients. PMID: 26766950 [PubMed] (Source: Psychiatry Investigation) MedWorm Sponsor Message: Directory of the best January… Continue reading The Hyperactivity of Efferent Auditory System in Patients with Schizophrenia: A Transient Evoked Otoacoustic Emissions Study.

Management of hearing loss in children

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 56 δευτερόλεπτα

This article outlines each of these options in detail according to conditions causing conductive or sensorineural hearing loss. (Source: Paediatrics and Child Health) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Nfee4Q via IFTTT

Deafness gene mutations in newborns in Beijing.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 56 δευτερόλεπτα

Conclusions The 235delC GJB2 mutation was the most frequent deafness-related mutation in the Chinese population. Genetic screening for the deafness gene will help detect more cases of newborn congenital HL than current screening practices. PMID: 26766211 [PubMed – as supplied by publisher] (Source: Acta Oto-Laryngologica) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader… Continue reading Deafness gene mutations in newborns in Beijing.

Management of chronic otitis media by subtotal petrosectomy.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 56 δευτερόλεπτα

CONCLUSIONS: A subtotal petrosectomy is rarely performed for the treatment of chronic otitis media. However, it is a technique that we have to keep in mind for the treatment of certain cases where there is recurrence and deep hearing loss, as well as in cases with good cochlear reserve if the disease coexists with other… Continue reading Management of chronic otitis media by subtotal petrosectomy.

Local woman advocates for Death with Dignity bill – Frederick News Post (subscription)

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 56 δευτερόλεπτα

The Akt/mTOR pathway is activated in verrucous carcinoma of the oral cavity

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 56 δευτερόλεπτα

Background The Akt/mTOR pathway is activated in many malignancies, including oral squamous cell carcinoma (OSCC). However, the role of the Akt/mTOR pathway in oral verrucous carcinoma (OVC), a low-grade variant of OSCC, remains unknown. Thus, the objective of this study was to investigate the activation level of important markers of the Akt/mTOR pathway in OVC… Continue reading The Akt/mTOR pathway is activated in verrucous carcinoma of the oral cavity

Circulating dentinal antigen-antibody immune complexes during orthodontic tooth movement in rats

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 56 δευτερόλεπτα

Background The immunogenic potential of dentin has been reported through dentin-reactive autoantibodies detection in human and animal model. This study aimed to investigate the formation and diagnostic value of immune complexes formation after autoantibodies production, and soluble dentin antigens levels associated to root resorption, in the course of orthodontic tooth movement, in rat experimental model.… Continue reading Circulating dentinal antigen-antibody immune complexes during orthodontic tooth movement in rats

Overexpression of Bcl-2, SOCS 1, 3 and Cdh 1, 2 are associated with the early neoplasic changes in modified 4-nitroquinoline 1-oxide-induced murine oral cancer model

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 56 δευτερόλεπτα

Background The objective was to assess histopathological changes and the expression of proliferating cell nuclear antigen (PCNA), Bcl-2, suppressor of cytokine signaling (SOCS) 1 and 3, Vimentin, TWIST1, and Cdh 1 and 2 in early stages of experimental oral carcinogenesis process using a shorter period of exposure to 4-nitroquinoline oxide (4-NQO) model. Methods In this… Continue reading Overexpression of Bcl-2, SOCS 1, 3 and Cdh 1, 2 are associated with the early neoplasic changes in modified 4-nitroquinoline 1-oxide-induced murine oral cancer model

IL-1β-regulating angiogenic factors expression in perforated temporomandibular disk cells via NF-κB pathway

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 56 δευτερόλεπτα

Background A high density of blood vessels is observed in the perforated disks of temporomandibular joint (TMJ), but the underlying mechanism is unknown. This study aimed to explore the regulation of disk angiogenesis in the perforated disks. Methods Expressions of vascular endothelial growth factor (VEGF), angiogenin-1 (Ang-1), chondromodulin-1 (ChM-1), and thrombospondins-1 (TSP-1) were compared between… Continue reading IL-1β-regulating angiogenic factors expression in perforated temporomandibular disk cells via NF-κB pathway

Cough suppressant

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Cough suppressant: A drug used to control coughing, particularly with a dry, nagging, unproductive cough. MedTerms (TM) is the Medical Dictionary of MedicineNet.com. We Bring Doctors’ Knowledge To You from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SXI7xZ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Musashi2 as a novel predictive biomarker for liver metastasis and poor prognosis in colorectal cancer

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Development and characterization of two human triple-negative breast cancer cell lines with highly tumorigenic and metastatic capabilities

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Expression of aurora kinase A correlates with the Wnt-modulator RACGAP1 in gastric cancer

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Characterization of copy number alterations in a mouse model of fibrosis-associated hepatocellular carcinoma reveals concordance with human disease

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Nimotuzumab enhances temozolomide-induced growth suppression of glioma cells expressing mutant EGFR in vivo

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Triage of patients with AUS/FLUS on thyroid cytopathology: effectiveness of the multimodal diagnostic techniques

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Direct comparison of 129Xe diffusion measurements with quantitative histology in human lungs

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Purpose Chronic obstructive pulmonary disease (COPD) is an irreversible lung disease characterized by small-airway obstruction and alveolar-airspace destruction. Hyperpolarized 129Xe diffusion MRI of lung is a promising biomarker for assessing airspace enlargement, but has yet to be validated by direct comparison to lung histology. Here we have compared diffusion measurements of hyperpolarized (HP) 129Xe in […]

A fast and flexible MRI system for the study of dynamic vocal tract shaping

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Purpose The aim of this work was to develop and evaluate an MRI-based system for study of dynamic vocal tract shaping during speech production, which provides high spatial and temporal resolution. Methods The proposed system utilizes (a) custom eight-channel upper airway coils that have high sensitivity to upper airway regions of interest, (b) two-dimensional golden […]

Automatic recognition of subject-specific cerebrovascular trees

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Purpose An image filter designed for reconstructing cerebrovascular trees from MR images is described. Current imaging techniques capture major cerebral vessels reliably, but often fail to detect small vessels, whose contrast is suppressed due to limited resolution, slow blood flow rate, and distortions around bifurcations or nonvascular structures. An incomplete view of angioarchitecture limits the […]

Direct comparison of 129Xe diffusion measurements with quantitative histology in human lungs

Musashi2 as a novel predictive biomarker for liver metastasis and poor prognosis in colorectal cancer

A fast and flexible MRI system for the study of dynamic vocal tract shaping

Development and characterization of two human triple-negative breast cancer cell lines with highly tumorigenic and metastatic capabilities

Automatic recognition of subject-specific cerebrovascular trees

Expression of aurora kinase A correlates with the Wnt-modulator RACGAP1 in gastric cancer

True and apparent optogenetic BOLD fMRI signals

Purpose Optogenetic fMRI (ofMRI) is a novel tool in neurophysiology and neuroimaging. The method is prone to light-induced artifacts, two of which were investigated in this study. Methods ofMRI was performed in rats using two excitatory opsins (ChR2 and C1V1TT) virally transduced in somatosensory cortex or thalamus. Heat-induced apparent BOLD activation at the site of […]

Characterization of copy number alterations in a mouse model of fibrosis-associated hepatocellular carcinoma reveals concordance with human disease

High-resolution diffusion-weighted imaging of the breast with multiband 2D radiofrequency pulses and a generalized parallel imaging reconstruction

Purpose To develop a technique for high-resolution diffusion-weighted imaging (DWI) and to compare it with standard DWI methods. Methods Multiple in-plane bands of magnetization were simultaneously excited by identically phase modulating each subpulse of a two-dimensional (2D) RF pulse. Several excitations with the same multiband pattern progressively shifted in the phase-encode direction were used to […]

Nimotuzumab enhances temozolomide-induced growth suppression of glioma cells expressing mutant EGFR in vivo

The Akt/mTOR pathway is activated in verrucous carcinoma of the oral cavity

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα

Circulating dentinal antigen-antibody immune complexes during orthodontic tooth movement in rats

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα

Overexpression of Bcl-2, SOCS 1, 3 and Cdh 1, 2 are associated with the early neoplasic changes in modified 4-nitroquinoline 1-oxide-induced murine oral cancer model

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα

Background The objective was to assess histopathological changes and the expression of proliferating cell nuclear antigen (PCNA), Bcl-2, suppressor of cytokine signaling (SOCS) 1 and 3, Vimentin, TWIST1, and Cdh 1 and 2 in early stages of experimental oral carcinogenesis process using a shorter period of exposure to 4-nitroquinoline oxide (4-NQO) model. Methods In this study, 20 rats were divided into control group (*n* = 10), sacrificed on the first day of the experiment, and experimental group (*n* = 10) treated with 50 ppm of 4-NQO solution dissolved in drinking water for 8 a... περισσότερα »

IL-1β-regulating angiogenic factors expression in perforated temporomandibular disk cells via NF-κB pathway

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα

Background A high density of blood vessels is observed in the perforated disks of temporomandibular joint (TMJ), but the underlying mechanism is unknown. This study aimed to explore the regulation of disk angiogenesis in the perforated disks. Methods Expressions of vascular endothelial growth factor (VEGF), angiogenin-1 (Ang-1), chondromodulin-1 (ChM-1), and thrombospondins-1 (TSP-1) were compared between healthy and perforated TMJ disk cells with or without interleukin-1β (IL-1β) incubation. The tube formation, cell migration, and expressions of matrix-metalloproteinases (MMPs)... περισσότερα »

Clinical Efficacy of Herbal Medicine for Pediatric Lymphatic Malformations: A Pilot Study

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα

Abstract Background Lymphatic malformations (LMs) are congenital malformations of the lymphatic system that commonly affect the head and neck region and cause marked cosmetic and functional complications. In this pilot study, we present eight children with LMs treated using an herbal medicine for this indication. Methods Between January 2009 and May 2014, eight children (four boys, four girls) with LMs were treated using oral administration of an herbal medicine, Eppikajyutsuto (TJ-28; Tsumura, Tokyo, Japan), as monotherapy. Results Four of the cases were macrocystic and four w... περισσότερα »

The Effectiveness of Written Action Plans in Atopic Dermatitis

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα

Abstract Atopic dermatitis (AD) is a chronic dermatosis requiring a stepwise and dynamic approach to management. The use of written action plans has been shown to improve outcomes in other chronic diseases that require a similar incremental approach. A systematic review was performed to evaluate the effect of a written eczema action plan (EAP) in AD management and to identify characteristics of effective action plans in children with eczema. Only two trials were identified as eligible, which highlights the need for more research on EAPs. from #Dermatology via alexandrossfakianaki...περισσότερα »

Cry-like genes, in an uncommon gene configuration, produce a crystal that localizes within the exosporium when expressed in an acrystalliferous strain of Bacillus thuringiensis

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα

Cry proteins are pesticidal toxins produced by the bacterium *Bacillus thuringiensis* (Bt), which aggregate in sporulating cells to form a crystal. Except in a relatively few cases, these crystals are located outside the exosporium that surrounds the spore. Bt2-56 is a strain of Bt that has the relatively uncommon characteristic of locating its Cry protein-containing crystal within the exosporium, and in association with a long, multi-fiber filament. With the ultimate goal of both understanding and manipulating the localization of Cry proteins within the exosporium, we sought to i... περισσότερα »

Using whole-genome sequencing to determine appropriate streptomycin epidemiological cutoffs for Salmonella and Escherichia coli

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα

For Enterobacteriaceae such as *Salmonella* spp. and *Escherichia coli*, no unified interpretive resistance criteria exist for streptomycin, an epidemiologically important antibiotic. As part of the National Antimicrobial Resistance Monitoring System (NARMS), we had previously used a minimum inhibitory concentration (MIC) of ≥64 μg/mL as an epidemiological cutoff value (ECV) to define non-wild-type isolates. To identify whether this ECV correlated with genetic determinants of resistance, we performed whole-genome sequencing of 463 *Salmonella* and *E. coli* isolates to identify st... περισσότερα »

Cry-like genes, in an uncommon gene configuration, produce a crystal that localizes within the exosporium when expressed in an acrystalliferous strain of Bacillus thuringiensis

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα

Using whole-genome sequencing to determine appropriate streptomycin epidemiological cutoffs for Salmonella and Escherichia coli

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα

Measuring B1 distributions by B1 phase encoding

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Purpose We propose a method to acquire distribution plots by encoding in instead of image space. Using this method, data is acquired in a different way from traditional spatial mapping, and allows for quick measurement of high dynamic range data. Methods To encode in , we acquire multiple projections of a slice, each along the […]

Accelerating functional MRI using fixed-rank approximations and radial-cartesian sampling

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Purpose Recently, k-t FASTER (fMRI Accelerated in Space-time by means of Truncation of Effective Rank) was introduced for rank-constrained acceleration of fMRI data acquisition. Here we demonstrate improvements achieved through a hybrid three-dimensional radial-Cartesian sampling approach that allows posthoc selection of acceleration factors, as well as incorporation of coil sensitivity encoding in the reconstruction. Methods […]

Ovarian Yolk Sac Tumor With High-Grade Serous Carcinoma in a 62-Year-Old Woman

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Utility of CD99 Paranuclear Expression in the Differential Diagnosis of Merkel Cell Carcinoma

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Background. Recent reviews have referred to the paranuclear dot-like staining pattern of CD99 in several neoplasms, including solid pseudopapillary tumors in the pancreas, colonic adenocarcinomas, and colonic adenomas as well as in Merkel cell carcinoma (MCC). The aim of this work was to explore the utility of CD99 paranuclear staining in the differential diagnosis of […]

The Akt/mTOR pathway is activated in verrucous carcinoma of the oral cavity

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Circulating dentinal antigen-antibody immune complexes during orthodontic tooth movement in rats

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Overexpression of Bcl-2, SOCS 1, 3 and Cdh 1, 2 are associated with the early neoplasic changes in modified 4-nitroquinoline 1-oxide-induced murine oral cancer model

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

IL-1β-regulating angiogenic factors expression in perforated temporomandibular disk cells via NF-κB pathway

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Transferred interbacterial antagonism genes augment eukaryotic innate immune function

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Nature from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Ork6Mz via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Aberrations and adaptive optics in super-resolution microscopy

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Microscopy from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ROCpzn via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Ovarian Yolk Sac Tumor With High-Grade Serous Carcinoma in a 62-Year-Old Woman

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα

Ovarian yolk sac tumors are germ cell tumors that usually present in children and young women. Rarely, these tumors can arise in older women, usually in conjunction with surface epithelial tumors, suggesting divergent differentiation from the latter. The combination of mixed ovarian yolk sac tumor and high-grade serous carcinoma is rare, with only one case documented in the literature. We present a case of mixed ovarian yolk sac tumor and high-grade serous carcinoma in a postmenopausal woman, including a brief discussion of the immunohistochemical findings and differential diagnos...περισσότερα »

Utility of CD99 Paranuclear Expression in the Differential Diagnosis of Merkel Cell Carcinoma

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα

*Background.* Recent reviews have referred to the paranuclear dot-like staining pattern of CD99 in several neoplasms, including solid pseudopapillary tumors in the pancreas, colonic adenocarcinomas, and colonic adenomas as well as in Merkel cell carcinoma (MCC). The aim of this work was to explore the utility of CD99 paranuclear staining in the differential diagnosis of MCC. *Material and Methods.* We explore paranuclear dot-like CD99 expression in several small, round blue cell neoplasms, including neuroendocrine neoplasms, Ewing sarcomas/primitive neuroectodermal tumors (EWS/PNE...περισσότερα »

Overexpression of Bcl-2, SOCS 1, 3 and Cdh 1, 2 are associated with the early neoplasic changes in modified 4-nitroquinoline 1-oxide-induced murine oral cancer model

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα

Background The objective was to assess histopathological changes and the expression of proliferating cell nuclear antigen (PCNA), Bcl-2, suppressor of cytokine signaling (SOCS) 1 and 3, Vimentin, TWIST1, and Cdh 1 and 2 in early stages of experimental oral carcinogenesis process using a shorter period of exposure to 4-nitroquinoline oxide (4-NQO) model. Methods In this study, 20 rats were divided into control group (*n* = 10), sacrificed on the first day of the experiment, and experimental group (*n* = 10) treated with 50 ppm of 4-NQO solution dissolved in drinking water for 8 a... περισσότερα »

IL-1β-regulating angiogenic factors expression in perforated temporomandibular disk cells via NF-κB pathway

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα

Background A high density of blood vessels is observed in the perforated disks of temporomandibular joint (TMJ), but the underlying mechanism is unknown. This study aimed to explore the regulation of disk angiogenesis in the perforated disks. Methods Expressions of vascular endothelial growth factor (VEGF), angiogenin-1 (Ang-1), chondromodulin-1 (ChM-1), and thrombospondins-1 (TSP-1) were compared between healthy and perforated TMJ disk cells with or without interleukin-1β (IL-1β) incubation. The tube formation, cell migration, and expressions of matrix-metalloproteinases (MMPs)... περισσότερα »

The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex

Cell Cycle from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ROCm6H via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1U5SM86 via IFTTT

POLE proofreading mutations elicit an anti-tumor immune response in endometrial cancer

Clinical cancer research : an official journal of the American Association for Cancer Research from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ROCmn5 via IFTTT

Evolutionarily conserved role for SoxC genes in neural crest specification and neuronal differentiation

Developmental biology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Ork33j via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RvjLfx via IFTTT

Let there be light: Regulation of gene expression in plants

RNA Biology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Ork5bf via IFTTT

Αρχειοθήκη ιστολογίου

Κυριακή 17 Ιανουαρίου 2016