New anatomo-radiological findings of the lateral pterygoid muscle
New anatomo-radiological findings of the lateral pterygoid muscle: Abstract PurposeThe discrepancies in the literature regarding the anatomy of the temporomandibular joint (TMJ), particularly at the level of the lateral pterygoid muscle, led us to compare plastinated section techniques and magnetic resonance imaging (MRI) to enable the better interpretation of both, and to describe the features of the lateral pterygoid muscle and the exact location of its insertions. MethodsA total of 24 blocks of human TMJ were used. Seven were studied by MRI, obtaining images of the oblique-s... περισσότερα »
Cone beam computed tomographic evaluation of nutrient canals and foramina in the anterior region of the mandible
Cone beam computed tomographic evaluation of nutrient canals and foramina in the anterior region of the mandible: Abstract PurposeTo investigate the incidence and anatomical location of mandibular nutrient canals (NCs) originating from the mandibular canal using dental cone beam computed tomography (CBCT). MethodsCBCT images from 105 patients were examined to evaluate the presence, number, diameter, and course of NCs. ResultsNCs and their foramina were bilaterally located in 17 (16.2 %) images. The mean diameters of NCs and foramina were 0.9 ± 0.4 (range, 0.2–3.2) mm and 0....περισσότερα »
The clinical significance of fibrinogen plasma levels in patients with diffuse large B cell lymphoma
The clinical significance of fibrinogen plasma levels in patients with diffuse large B cell lymphoma: Background Fibrinogen plays a crucial role in the pathophysiology of tumour cell growth, invasion and metastasis. The aim of this study was to evaluate the prognostic significance of pretreatment plasma fibrinogen levels in patients with diffuse large B cell lymphoma (DLBCL) Methods Data from 372 patients with DLBCL, diagnosed and treated between 2004 and 2013 at two Austrian centres, were evaluated retrospectively. The prognostic influences of plasma fibrinogen levels and other fa... περισσότερα »
Patient survives stage IV, inoperable throat cancer in clinical trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Source: medicalxpress.com Author: staff It took a white lie to get David Polisini, 79, to a doctor in 2004, after months of being unable to swallow. “Two of my daughters, Toni and Susie, showed up on my back porch and told me to put my jacket on,” he says. “They told me we were just […]
Call for NZ Government to fund HPV vaccine for boys
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Source: http://www.nzherald.co.nz Author: Martin Johnston Throat-cancer patient Grant Munro paid for his son to be vaccinated against the sexually-transmitted HPV virus because the Government has refused. A 58-year-old scientific expert on viruses, he is backing a campaign by doctors calling for the extension of state funding of the controversial HPV vaccine to boys. Dr Munro, […]
Costco Wholesale to stop selling tobacco products at hundreds of locations
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Source: http://www.medicaldaily.com Author: Jaleesa Baulkman Sorry smokers, but you’ll have to go someplace other than Costco to get your cigarettes. The New York Daily News reported the retailer has spent the past few years quietly phasing tobacco products out of nearly 300 stores; there are 488 in total. Tobacco smoke has been linked to adverse […]
Detection of Epstein-Barr virus in different sources of materials from patients with oral lichen planus: a case-control study
Detection of Epstein-Barr virus in different sources of materials from patients with oral lichen planus: a case-control study: Aims To detect the presence of Epstein–Barr virus (EBV) DNA in different sources of materials from a matched group of patients with oral lichen planus (OLP) and a group of people without OLP lesions, and to correlate the presence of virus with epidemiological variables of the groups studied. Methods Fresh tissue samples, saliva, exfoliated cells and plasma of 24 patients with OLP lesions (cases) and 17 patients without OLP lesions (controls) were collected.... περισσότερα »
Antiphospholipid syndrome presenting as cerebral venous sinus thrombosis
Antiphospholipid syndrome presenting as cerebral venous sinus thrombosis: a case series and a review: The cerebral venous sinus system is a rare site for venous thrombosis except in patients with antiphospholipid syndrome. We describe three patients presenting with cerebral venous thrombosis in association with other thrombotic sites in two patients and as an only site in one patient. Antiphospholipid syndrome has varied clinical manifestations but the defining feature is the persistent presence of antiphospholipid antibodies. In this report we will review the clinical and laborato... περισσότερα »
Patient survives stage IV, inoperable throat cancer in clinical trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Source: medicalxpress.com Author: staff It took a white lie to get David Polisini, 79, to a doctor in 2004, after months of being unable to swallow. “Two of my daughters, Toni and Susie, showed up on my back porch and told me to put my jacket on,” he says. “They told me we were just […]
Call for NZ Government to fund HPV vaccine for boys
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Source: http://www.nzherald.co.nz Author: Martin Johnston Throat-cancer patient Grant Munro paid for his son to be vaccinated against the sexually-transmitted HPV virus because the Government has refused. A 58-year-old scientific expert on viruses, he is backing a campaign by doctors calling for the extension of state funding of the controversial HPV vaccine to boys. Dr Munro, […]
Costco Wholesale to stop selling tobacco products at hundreds of locations
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Source: http://www.medicaldaily.com Author: Jaleesa Baulkman Sorry smokers, but you’ll have to go someplace other than Costco to get your cigarettes. The New York Daily News reported the retailer has spent the past few years quietly phasing tobacco products out of nearly 300 stores; there are 488 in total. Tobacco smoke has been linked to adverse […]
Redefining cancer and cure
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Nature Reviews Clinical Oncology 13, 199 (2016). doi:10.1038/nrclinonc.2016.46 Author: Lisa Hutchinson As our understanding of cancer evolves, in parallel, we must evaluate how we define this disease in its simplest terms and what we mean by cure. In the advanced disease setting, downstaging a tumour with neoadjuvant chemotherapy to remove the faster-growing cancer cells and […]
Health policy: Strategies to optimize expedited investigational new drug safety reports
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Nature Reviews Clinical Oncology 13, 207 (2016). doi:10.1038/nrclinonc.2016.42 Author: Apostolia M. Tsimberidou Accurate and efficient expedited investigational new drug (IND) reporting is a crucial component of clinical research. The FDA, pharmaceutical companies, institutional review boards, and clinical investigators should develop dynamic standardized electronic forms with preferred, predetermined terms to harmonize their practices and to help […]
Pancreatic cancer: A problem quartered — new subtypes, new solutions?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Nature Reviews Clinical Oncology 13, 201 (2016). doi:10.1038/nrclinonc.2016.39 Author: David Killock Despite new drug approvals, pancreatic cancer remains one of the most-difficult-to-treat cancers, and the prognosis of patients with advanced-stage disease is dire. Now, the results of an integrated analysis of genomic, epigenetic, and transcriptomic data, generated by the Australian Pancreatic Cancer Genome Initiative as […]
Immunotherapy: Antitumour T cells as peripheral biomarkers
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Nature Reviews Clinical Oncology 13, 203 (2016). doi:10.1038/nrclinonc.2016.38 Author: Lisa Hutchinson Common epithelial cancers are responsible for 90% of all cancer deaths. Until recently, few curative options existed for metastatic disease. However, the greatest advances in cancer research are often witnessed when two technologies dovetail to unlock the potential of curative therapy. In no area […]
Immunotherapy: PD-1 says goodbye, TIM-3 says hello
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Nature Reviews Clinical Oncology 13, 202 (2016). doi:10.1038/nrclinonc.2016.40 Author: Diana Romero Immune-checkpoint inhibitors, notably antibodies targeting the PD-1/PD-L1 axis, have demonstrated efficacy as therapeutic agents for several tumour types. As Peter Hammerman explains, however, “little is known about which patients are likely to respond to these agents and, if they respond, the possible mechanisms of […]
Gastrointestinal cancer: PICCOLO — changing the tune of anti-EGFR therapy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Nature Reviews Clinical Oncology 13, 202 (2016). doi:10.1038/nrclinonc.2016.32 Author: David Killock Anti-EGFR antibodies are offered to patients with colorectal cancer (CRC) only if they have RAS-wildtype disease; however, even these patients often derive limited or no benefit. Indeed, Jenny Seligmann, Matthew Seymour, and colleagues have now shown that only patients with both RAS-wild-type CRC from […]
Sarcoma: Eribulin — a welcomed advance
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Nature Reviews Clinical Oncology 13, 204 (2016). doi:10.1038/nrclinonc.2016.33 Author: Diana Romero Treatment of soft-tissue sarcomas constitutes an unmet medical need: half of the patients diagnosed with these malignancies do not respond to the initial treatment — surgery and anthracycline-based chemotherapy — and, therefore, the median survival duration is approximately 1 year. Now, findings of a […]
The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease
The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease: Human parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblasts in the bone marrow. B19 infection commonly causes erythema infectiosum, arthralgia, fetal death, transient aplastic crisis in patients with shortened red cell survival, and persistent infection in people who are immunocompromised. Less common clinical manifestations include atypical skin rashes, neurological syndromes, cardiac syndromes, and various cytopenias. B19 infection has also been associated...περισσότερα »
PIK3CA promotes proliferation and motility but is unassociated with lymph node metastasis or prognosis in esophageal squamous cell carcinoma
PIK3CA promotes proliferation and motility but is unassociated with lymph node metastasis or prognosis in esophageal squamous cell carcinoma: The PIK3CA mutation has been extensively reported in the setting of cancers; however, the clinicopathologic significance of PIK3CA expression has rarely been discussed in esophageal squamous cell carcinoma (ESSC). In the present study, to confirm the significance of PIK3CA expression in association with metastasis and prognosis, which has been somewhat controversial in ESCC, the relationship between clinicopathologic features of ESCC and PIK3CA... περισσότερα »
Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials
Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials: AbstractThe efficacy of PD-1/PD-L1 targeted therapies in addition to anti-CTLA-4 solidifies immunotherapy as a modality to add to the anticancer arsenal. Despite raising the bar of clinical efficacy, immunologically targeted agents raise new challenges to conventional drug development paradigms by highlighting the limited relevance of assessing standard pharmacokinetics (PK) and pharmacodynamics (PD). Specifically, systemic and intratumoral immune effects have not c...περισσότερα »
Using the galactose-α-1,3-galactose enzyme-linked immunosorbent assay to predict anaphylaxis in response to cetuximab
Using the galactose-α-1,3-galactose enzyme-linked immunosorbent assay to predict anaphylaxis in response to cetuximab by Jared Weiss, Juneko Grilley Olson, Allison Mary Deal, Bhishamjit Chera, Mark Weissler, Barbara A. Murphy, David Neil Hayes, Jill Gilbert via Cancer [image: cover.gif?v=1&s=ac8254088193565bc910ec22] BACKGROUND Cetuximab is a monoclonal antibody against epidermal growth factor receptor with activity against head and neck cancer and colorectal cancer. Anaphylaxis in response to cetuximab is a significant clinical problem in the Southeastern United States with a grade ...περισσότερα »
Phase I study with ONCOS-102 for the treatment of solid tumors – an evaluation of clinical response and exploratory analyses of immune markers
Phase I study with ONCOS-102 for the treatment of solid tumors – an evaluation of clinical response and exploratory analyses of immune markers: Abstract BackgroundWe conducted a phase I study with a granulocyte macrophage colony stimulating factor (GMCSF)-expressing oncolytic adenovirus, ONCOS-102, in patients with solid tumors refractory to available treatments. The objectives of the study were to determine the optimal dose for further use and to assess the safety, tolerability and adverse event (AE) profile of ONCOS-102. Further, the response rate and overall survival were evalua... περισσότερα »
Thrombocytopenia and craniotomy for tumor
: A National Surgical Quality Improvement Program analysis by Hormuzdiyar H. Dasenbrock, Christopher A. Devine, Kevin X. Liu, William B. Gormley, Elizabeth B. Claus, Timothy R. Smith, Ian F. Dunn via Cancer BACKGROUND To the authors' knowledge, the current study is the first national analysis of the association between preoperative platelet count and outcomes after craniotomy. METHODS Patients who underwent craniotomy for tumor were extracted from the prospective National Surgical Quality Improvement Program registry (2007-2014) and stratified by preoperative thrombocytopenia, defined ... περισσότερα »
Rewarded visual items capture attention only in heterogeneous contexts
Abstract Reward is known to affect visual search performance. Rewarding targets can increase search performance, whereas rewarding distractors can decrease search performance. We used subcomponents of the N2pc in the event-related EEG, the NT (target negativity) and ND/PD (distractor negativity/positivity), in a visual search task to disentangle target and distractor processing related to reward. The visual search task comprised homogeneous and heterogeneous contexts in which a target and a colored distractor were embedded. After each correct trial, participants were given a moneta...περισσότερα »
One-year developmental stability and covariance among oddball, novelty, go/no-go, and flanker event-related potentials in adolescence: A monozygotic twin study
Abstract ERP measures may index genetic risk for psychopathology before disorder onset in adolescence, but little is known about their developmental rank-order stability during this period of significant brain maturation. We studied ERP stability in 48 pairs of identical twins (age 14–16 years) tested 1 year apart. Trial-averaged voltage waveforms were extracted from electroencephalographic recordings from oddball/novelty, go/no-go, and flanker tasks, and 16 amplitude measures were examined. Members of twin pairs were highly similar, whether based on ERP amplitude measures (intracl... περισσότερα »
Swallowing disorders, dysgeusia, oral mucositis and xerostomia on nutritional status, oral intake and weight loss in head and neck cancer patients
The effects of swallowing disorders, dysgeusia, oral mucositis and xerostomia on nutritional status, oral intake and weight loss in head and neck cancer patients: a systematic review via ScienceDirect Publication: Cancer Treatment Reviews [image: S03057372.gif] Publication date: Available online 14 March 2016 *Source:*Cancer Treatment Reviews Author(s): Valentina Bressan, Simone Stevanin, Monica Bianchi, Giuseppe Aleo, Annamaria Bagnasco, Loredana Sasso BackgroundCombined-modality treatment of head and neck cancer is becoming more common, driven by the idea that organ(s) preservation ... περισσότερα »
18F-FDG PET at diagnosis in patients with soft tissue sarcoma and bone sarcoma
Prognostic significance of 18F-FDG PET at diagnosis in patients with soft tissue sarcoma and bone sarcoma; systematic review and meta-analysis via ScienceDirect Publication: European Journal of Cancer Publication date: May 2016 *Source:*European Journal of Cancer, Volume 58 Author(s): Tadahiko Kubo, Taisuke Furuta, Muhammad P. Johan, Mitsuo Ochi PurposeThe usefulness of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) for the survival prognosis in soft tissue sarcoma (STS) and bone sarcoma (BS) is controversial. The objective of this systematic review was to provide an ... περισσότερα »
Human papillomavirus infection and risk of breast cancer
Human papillomavirus infection and risk of breast cancer: a meta-analysis of case-control studies: Abstract BackgroundAlthough systematic reviews (SR) report that human papillomavirus (HPV) increases the risk of breast cancer, there are still disputes regarding this association. In particular, it has been argued that the risk level differs depending on nationality, type of tissue, subtype of HPV, and publication year. Considering that the searching year of publication for the previous SRs was June 2013, a renewal meta-analysis needs to be conducted. MethodsUsing articles selec... περισσότερα »
Program Director Opinion on the Ideal Length of Residency Training in Emergency Medicine
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Abstract Objective This study sought to define expert opinion on the ideal length of training (LoT) for ACGME-accredited emergency medicine (EM) residency programs. Methods A cross-sectional web-based survey was sent to program directors (PDs) at all ACGME-accredited EM residency programs during a study period of August – October 2014. The primary outcome of ideal LoT […]
Sustainable Mechanism to Reduce ED Length of Stay: The Use of Emergency Department Holding (ED Transition) Orders to Reduce ED Length of Stay
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Abstract Objective To evaluate the effect of an emergency clinician initiated “ED Admission Holding Order Set” on emergency department treatment times and length of stay. We further describe the impact of a performance improvement strategy with sequential PDSA cycles used to influence the primary outcome measures, ED length of stay (EDLOS) and Disposition Decision to […]
A Histomorphological Pattern Analysis of Pulmonary Tuberculosis in Lung Autopsy and Surgically Resected Specimens
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Background. Tuberculosis (TB) is a major cause of morbidity and mortality globally. Many cases are diagnosed on autopsy and a subset of patients may require surgical intervention either due to the complication or sequelae of TB. Materials and Methods. 40 cases of resected lung specimens following surgery or autopsy in which a diagnosis of pulmonary […]
Human papillomavirus type 16 viral load is decreased following a therapeutic vaccination
Human papillomavirus type 16 viral load is decreased following a therapeutic vaccination: AbstractIn the dose-escalation phase of a Phase I clinical trial in which six subjects each were vaccinated with PepCan at the 50, 100, 250, and 500 μg per peptide dose, the 50 μg dose showed the best histological regression rate. Ten additional subjects were vaccinated at this dose in the final dose phase. As with the dose-escalation phase, no dose-limiting toxicities were observed. Overall, the histological regression rates were 50 % at the 50 μg dose (7 of 14) and 100 μg dose (3 of 6), and ... περισσότερα »
Surgery and definitive chemoradiotherapy for patients with resectable esophageal squamous cell carcinoma
Comparison between surgery and definitive chemoradiotherapy for patients with resectable esophageal squamous cell carcinoma: a propensity score analysis: Abstract PurposeOur intent was to compare survival following neoadjuvant chemotherapy followed by surgery versus chemoradiotherapy (CRT) among patients with potentially resectable esophageal squamous cell carcinoma. MethodsInformation about 406 consecutive esophageal cancer patients with resectable disease who underwent surgery with neoadjuvant chemotherapy consisting of cisplatin plus 5-fluorouracil or who underwent definitiv...περισσότερα »
Bloodstream infections
Bloodstream infections in patients with chronic lymphocytic leukemia: a longitudinal single-center study: AbstractInfectious complications in chronic lymphocytic leukemia (CLL) represent a major cause of morbidity and mortality. The aim of the study was to investigate temporal trends in bloodstream infections (BSIs) among patients with CLL. Individuals with blood cultures were linked to Swedish Cancer Registry and divided into three time periods (1988–1993, 1994–1999, and 2000–2006) according to year of CLL diagnosis. CLL patients (*n* = 275) with 1092 blood culture episodes were i... περισσότερα »
Cryosurgery Training
Graphics Processing Unit-Based Bioheat Simulation to Facilitate Rapid Decision Making Associated with Cryosurgery Training: This study focuses on the implementation of an efficient numerical technique for cryosurgery simulations on a graphics processing unit as an alternative means to accelerate runtime. This study is part of an ongoing effort to develop computerized training tools for cryosurgery, with prostate cryosurgery as a developmental model. The ability to perform rapid simulations of various test cases is critical to facilitate sound decision making associated with medical... περισσότερα »
Radiotherapy of Hodgkin and Non-Hodgkin Lymphoma
Radiotherapy of Hodgkin and Non-Hodgkin Lymphoma: A Nonrigid Image-Based Registration Method for Automatic Localization of Prechemotherapy Gross Tumor Volume: Purpose: To improve the contouring of clinical target volume for the radiotherapy of neck Hodgkin/non-Hodgkin lymphoma by localizing the prechemotherapy gross target volume onto the simulation computed tomography using [18F]-fluorodeoxyglucose positron emission tomography/computed tomography. Material and Methods: The gross target volume delineated on prechemotherapy [18F]-fluorodeoxyglucose positron emission tomography/compu... περισσότερα »
Assessment of Sentinel Node Biopsies With Full-Field Optical Coherence Tomography
Assessment of Sentinel Node Biopsies With Full-Field Optical Coherence Tomography: Current techniques for the intraoperative analysis of sentinel lymph nodes during breast cancer surgery present drawbacks such as time and tissue consumption. Full-field optical coherence tomography is a novel noninvasive, high-resolution, fast imaging technique. This study investigated the use of full-field optical coherence tomography as an alternative technique for the intraoperative analysis of sentinel lymph nodes. Seventy-one axillary lymph nodes from 38 patients at Tenon Hospital were imaged ...περισσότερα »
Liposomal Doxorubicin Treatment of Superficial Tumors by Thermotherapy
Improved Efficacy of Liposomal Doxorubicin Treatment of Superficial Tumors by Thermotherapy: Our study aimed to investigate the effect of ultrasonic thermotherapy on the targeted delivery of liposomal doxorubicin to superficial tumors, local drug concentrations in tumor tissue, and the curative effect of chemotherapy. Twenty rabbits with VX2 tumors transplanted into the superficial muscle of the hind limb were randomly assigned to the following 4 treatment groups: (1) free doxorubicin, (2) liposomal doxorubicin hydrochloride, (3) liposomal doxorubicin hydrochloride plus 41°C therm... περισσότερα »
Radiation Carcinogenesis
Does Imaging Technology Cause Cancer? Debunking the Linear No-Threshold Model of Radiation Carcinogenesis: In the past several years, there has been a great deal of attention from the popular media focusing on the alleged carcinogenicity of low-dose radiation exposures received by patients undergoing medical imaging studies such as X-rays, computed tomography scans, and nuclear medicine scintigraphy. The media has based its reporting on the plethora of articles published in the scientific literature that claim that there is "no safe dose" of ionizing radiation, while essentially ig...περισσότερα »
Image-Guided Radiosurgery for Intracranial Lesions
Targeting Accuracy of Image-Guided Radiosurgery for Intracranial Lesions: A Comparison Across Multiple Linear Accelerator Platforms: Purpose: To evaluate the overall positioning accuracy of image-guided intracranial radiosurgery across multiple linear accelerator platforms. Methods: A computed tomography scan with a slice thickness of 1.0 mm was acquired of an anthropomorphic head phantom in a BrainLAB U-frame mask. The phantom was embedded with three 5-mm diameter tungsten ball bearings, simulating a central, a left, and an anterior cranial lesion. The ball bearings were positione... περισσότερα »
The clinical value of HPV genotyping in triage of women with high-risk-HPV-positive self-samples
The clinical value of HPV genotyping in triage of women with high-risk-HPV-positive self-samples: [image: cover.gif?v=1&s=4e5ca00fc0f654475a245093] Abstract *Objective* Cytology alone, or combined with HPV16/18 genotyping, might be an acceptable method for triage in hrHPV-cervical cancer screening. Previously studied HPV-genotype based triage algorithms are based on cytology performed without knowledge of hrHPV status. The aim of this study was to explore the value of hrHPV genotyping combined with cytology as triage tool for hrHPV-positive women. *Methods* 520 hrHPV-positive wo... περισσότερα »
Detection of human papillomavirus type 16 in oropharyngeal squamous cell carcinoma using droplet digital polymerase chain reaction
Detection of human papillomavirus type 16 in oropharyngeal squamous cell carcinoma using droplet digital polymerase chain reaction: [image: cover.gif?v=1&s=ac8254088193565bc910ec22] BACKGROUND The incidence of oropharyngeal squamous cell carcinoma caused by oncogenic HPV (HPV-OPSCC) is rising worldwide. HPV-OPSCC is commonly diagnosed by RT-qPCR of HPV-16 E6 and E7 oncoproteins or by cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor 1 (p16) immunohistochemistry (IHC). Droplet digital PCR (ddPCR) has been recently reported as ultra-sensitive and highly precise metho... περισσότερα »
An automated electronic system for radiation treatment plan
An automated electronic system for radiation treatment plan peer review reduces missed reviews at a large, high-volume academic center via Practical Radiation Oncology Publication date: Available online 16 March 2016 *Source:*Practical Radiation Oncology Author(s): Peter E. Gabriel, Kristina D. Woodhouse, Alexander Lin, Jarod C. Finlay, Richard B. Young, Edna Volz, Stephen M. Hahn, James M. Metz, Amit Maity BackgroundAssuring quality in cancer care through peer review has become increasingly important in radiation oncology. In 2012, the Department of Radiation Oncology at XX implemente... περισσότερα »
Human papillomavirus detection
Human papillomavirus detection in a “Digital” age: It is increasingly important to identify the presence of human papillomavirus (HPV) in patients with oropharyngeal squamous cell carcinoma, because HPV status is now useful for clinical trial stratification, prognostic determination, diagnosis in patients with neck masses, and identification of the primary tumor site. Therefore, it is important that the technique used for identification be feasible, accurate, reproducible, and cost effective. The authors summarize these aspects of HPV detection and the use of newer digital polymera... περισσότερα »
Primary Kaposi’s sarcoma of the nasal cavity
Primary Kaposi’s sarcoma of the nasal cavity: a case report and review of the literature: Abstract BackgroundKaposi sarcoma is a neoplastic vascular disorder. It usually present on the skin of the upper and lower extremities, rarely in the mucosa of the head and neck. The most common sites reported are within the oral cavity, particularly on the palate. Other mucosal sites are rare. We present an unusual case where the primary manifestation of the Kaposi’s sarcoma was in the nasal mucosa. Case presentationA 56-year-old female of Mediterranean descent presented with a 1 year hi... περισσότερα »
Role of Epstein-Barr virus status and immunophenotypic studies in the evaluation of exfoliative cytology specimens from patients with post-transplant lymphoproliferative disorders
Role of Epstein-Barr virus status and immunophenotypic studies in the evaluation of exfoliative cytology specimens from patients with post-transplant lymphoproliferative disorders: BACKGROUND Post-transplant lymphoproliferative disorders (PTLDs) are well characterized in tissue sections, but their evaluation in exfoliative cytology specimens is limited. This study reports a 25-year experience with PTLDs in exfoliative cytology specimens. METHODS All solid organ or allogeneic stem cell transplant recipients with PTLDs and exfoliative cytology specimens from 1987 to 2011 were identifi...περισσότερα »
Neuroplastic Response following Radiotherapy for Pediatric Brain Tumors
: A Pilot Study via International Journal of Radiation Oncology*Biology*Physics Publication date: Available online 17 March 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics Author(s): Carol L. Armstrong, Michael J. Fisher, Yimei Li, Robert A. Lustig, Jean B. Belasco, Jane E. Minturn, Christine E. Hill-Kayser, Sonny Batra, Peter C. Phillips Purpose/ObjectivesClinically effective measurement of cognitive toxicity from photon radiotherapy (XRT) should be accurate, sensitive, and specific. This pilot study tests translational findings on phasic changes in children’... περισσότερα »
Registry-based outcome assessment in haemophilia: a scoping study to explore the available evidence
Abstract Haemophilia is a congenital disorder with bleeding episodes as its primary symptom. These episodes can result in negative outcomes including joint damage, loss of active days due to hospitalization and reduced quality of life. Effective treatment, however, can improve the outcome. Registries have been used as a valuable source of information regarding the monitoring of treatment and outcome. The two main aims of this exploratory study were to establish which haemophilia registries publish peer-reviewed outcome assessment research and then to extract, classify and report th... περισσότερα »
Invention of a novel photodynamic therapy for tumors using a photosensitizing PI3K inhibitor
Invention of a novel photodynamic therapy for tumors using a photosensitizing PI3K inhibitor: Abstract XL147 (SAR245408, pilaralisib), an ATP-competitive pan-class I phosphoinositide 3-kinase (PI3K) inhibitor, is a promising new anticancer drug. We examined the effect of the PI3K inhibitor on PC3 prostate cancer cells under a fluorescence microscope and found that XL147-treated cancer cells are rapidly injured by blue wavelength (430 nm) light irradiation. During the irradiation, the cancer cells treated with 0.2–2 μM XL147 showed cell surface blebbing and cytoplasmic vacuolation, ... περισσότερα »
Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors
Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors: Abstract ObjectivesPatients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinomas (OPSCCs) have an improved prognosis compared to HPV-negative OPSCCs. Several theories have been proposed to explain this relatively good prognosis. One hypothesis is a difference in immune response. In this study, we compared tumor-infiltrating CD3+, CD4+, CD8+ T-cells, and granzyme inhibitors (SERPINB1, SERPINB4, and SERPINB9) between HPV-positive and HPV-negative tumors and the relation with... περισσότερα »
High-dose methotrexate in infants aged less than 12 months
Pharmacokinetics of high-dose methotrexate in infants aged less than 12 months treated for aggressive brain tumors via http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=280&channel-name=Cancer+Chemotherapy+and+Pharmacology AbstractPurposeIn infants aged less than 12 months, there are few data on pharmacokinetics of high-dose methotrexate (MTX) for brain tumors at the dose of 8 g/m2. Consolidated knowledges are present only with the dose of 5 g/m2 in acute lymphoblastic leukemia. MethodsWe collected data on 8 infants at the time of their first treatment wi... περισσότερα »
pAKT Expression and Response to Sorafenib in Differentiated Thyroid Cancer
pAKT Expression and Response to Sorafenib in Differentiated Thyroid Cancer via http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=12672&channel-name=Hormones+and+Cancer AbstractSorafenib has an antitumor activity in patients with radioactive iodine-refractory differentiated thyroid carcinoma (RAIR-DTC). Prior research has implicated signaling through the MAPK and AKT/PI3K pathways in the progression of DTC. To assess whether the activity of these pathways is predictive of response to sorafenib, we retrospectively studied molecular tumor markers from these ... περισσότερα »
Bioluminescence Tomography–Guided Radiation Therapy
for Preclinical Research via International Journal of Radiation Oncology*Biology*Physics Publication date: 1 April 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics, Volume 94, Issue 5 Author(s): Bin Zhang, Ken Kang-Hsin Wang, Jingjing Yu, Sohrab Eslami, Iulian Iordachita, Juvenal Reyes, Reem Malek, Phuoc T. Tran, Michael S. Patterson, John W. Wong PurposeIn preclinical radiation research, it is challenging to localize soft tissue targets based on cone beam computed tomography (CBCT) guidance. As a more effective method to localize soft tissue targets, we devel...περισσότερα »
Temporal Cerebral Microbleeds Are Associated With Radiation Necrosis and Cognitive Dysfunction
in Patients Treated for Nasopharyngeal Carcinoma via International Journal of Radiation Oncology*Biology*Physics Publication date: 1 April 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics, Volume 94, Issue 5 Author(s): Qingyu Shen, Focai Lin, Xiaoming Rong, Wuyang Yang, Yi Li, Zhaoxi Cai, Pengfei Xu, Yongteng Xu, Yamei Tang PurposeRadiation therapy for patients with nasopharyngeal carcinoma (NPC) may be complicated with radiation-induced brain necrosis (RN), resulting in deteriorated cognitive function. However, the underlying mechanism of this phenomenon rem... περισσότερα »
The treatment outcome of nasopharyngeal cancer (NPC) across the world and its correlation with access to radiation therapy (RT)
Global Pattern of Nasopharyngeal Cancer: Correlation of Outcome With Access to Radiation Therapy via International Journal of Radiation Oncology*Biology*Physics Publication date: 1 April 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics, Volume 94, Issue 5 Author(s): Ka-On Lam, Anne W.M. Lee, Cheuk-Wai Choi, Henry C.K. Sze, Anthony L. Zietman, Kirsten I. Hopkins, Eduardo Rosenblatt PurposeThis study aimed to estimate the treatment outcome of nasopharyngeal cancer (NPC) across the world and its correlation with access to radiation therapy (RT).Methods and Materia... περισσότερα »
Hippocampal Neurogenesis After Irradiation
Effects of Aging on via International Journal of Radiation Oncology*Biology*Physics Publication date: 1 April 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics, Volume 94, Issue 5 Author(s): Zoey Cheng, Yu-Qing Li, C. Shun Wong PurposeTo assess the influence of aging on hippocampal neuronal development after irradiation (IR).Methods and MaterialsMale mice, 2, 4, 6, 12, and 18 months of age, were given a single dose of 0 or 5 Gy of IR. A bromodeoxyuridine (BrdU) incorporation study was used to label newborn cells. Neural progenitors, newborn neurons, and microg... περισσότερα »
Botulinum Toxin Confers Radioprotection in Salivary Glands
Botulinum Toxin Confers Radioprotection in Murine Salivary Glands via International Journal of Radiation Oncology*Biology*Physics Publication date: 1 April 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics, Volume 94, Issue 5 Author(s): Youssef H. Zeidan, Nan Xiao, Hongbin Cao, Christina Kong, Quynh-Thu Le, Davud Sirjani PurposeXerostomia is a common radiation sequela, which has a negative impact on the quality of life of patients with head and neck cancer. Current treatment strategies offer only partial relief. Botulinum toxins (BTX) have been successfully use... περισσότερα »
Whole-brain radiation therapy
Impact of image guidance during via Practical Radiation Oncology Publication date: Available online 19 March 2016 *Source:*Practical Radiation Oncology Author(s): Eric Ojerholm, Nathan Anderson, Kashyapkumar Patel, Peng Wang, Robert A. Lustig, Michelle Alonso-Basanta, Goldie Kurtz, Joshua A. Jones PurposeRadiation oncologists are rapidly adopting image-guided radiation therapy (IGRT), warranting further evaluation of its role and value. We analyzed the impact of IGRT for one of the most common radiation treatments.Methods and MaterialsWe retrospectively identified patients who receive... περισσότερα »
Pathology concordance levels for meningioma classification and grading in NRG Oncology RTOG Trial 0539
Pathology concordance levels for meningioma classification and grading in NRG Oncology RTOG Trial 0539: Background With advances in the understanding of histopathology on outcome, accurate meningioma grading becomes critical and drives treatment selection. The 2000 and 2007 WHO schema greatly increased the proportion of grade II meningiomas. Although associations with progression-free survival (PFS) and overall survival (OS) have been independently validated, interobserver concordance has not been formally assessed. Methods Once mature, NRG Oncology RTOG-0539 will report PFS and OS... περισσότερα »
Cell Kill During SABR: Do Hypoxia and Reoxygenation Really Matter?
Stochastic Predictions of via International Journal of Radiation Oncology*Biology*Physics Publication date: Available online 19 March 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics Author(s): Wendy Harriss-Phillips, Eva Bezak, Andrew Potter PurposeTo simulate Stereotactic Ablative Radiotherapy on hypoxic and well-oxygenated in-silico tumours, incorporating probabilistic parameter distributions and linear-quadratic (LQ) versus linear-quadratic-cubic (LQC) methodology and the evaluation of optimal fractionation schemes using Biological Effective Doses (BEDα/β=1...περισσότερα »
Reirradiation of Head and Neck Cancers with IMRT
: Outcomes and Analyses via International Journal of Radiation Oncology*Biology*Physics Publication date: Available online 19 March 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics Author(s): Vinita Takiar, Adam S. Garden, Dominic Ma, William H. Morrison, Mark Edson, Mark Zafereo, Gary B. Gunn, Clifton D. Fuller, Beth Beadle, Steven J. Frank, William N. William, Merrill Kies, A.K. El-Naggar, Randal Weber, David I. Rosenthal, Jack Phan Re-irradiation with IMRT and chemotherapy is a feasible option for patients with recurrent H&N cancer. Patients with SCC histolog...περισσότερα »
Implanting straight into cochlea risks the facial nerve: a Cartesian coordinate study.
*Implanting straight into cochlea risks the facial nerve: a Cartesian coordinate study.* Surg Radiol Anat. 2016 Mar 19; Authors: Deshpande AS, Wendell Todd N Abstract PURPOSE: To describe the straight-into-cochlea line that affords the best access for an electrode array to enter via the round window, and how this line relates to the facial nerve, the incus, and mastoid size. The straight-into-cochlea line is important to minimize the cochlear trauma and maximize the likelihood of placement into the scala tympani. METHODS: High-resolution CT scans were obtained for ten craniums wit... περισσότερα »
Expanded phenotypic spectrum of the m.8344A>G "MERRF" mutation: data from the German mitoNET registry.
*Expanded phenotypic spectrum of the m.8344A>G "MERRF" mutation: data from the German mitoNET registry.* J Neurol. 2016 Mar 19; Authors: Altmann J, Büchner B, Nadaj-Pakleza A, Schäfer J, Jackson S, Lehmann D, Deschauer M, Kopajtich R, Lautenschläger R, Kuhn KA, Karle K, Schöls L, Schulz JB, Weis J, Prokisch H, Kornblum C, Claeys KG, Klopstock T Abstract The m.8344A>G mutation in the MTTK gene, which encodes the mitochondrial transfer RNA for lysine, is traditionally associated with myoclonic epilepsy and ragged-red fibres (MERRF), a multisystemic mitochondrial disease that is cha... περισσότερα »
Relapsing polychondritis and lymphocytic meningitis with varied neurological symptoms.
*Relapsing polychondritis and lymphocytic meningitis with varied neurological symptoms.* Rev Bras Reumatol. 2016 Feb 5; Authors: Ducci RD, Germiniani FM, Czecko LE, Paiva ES, Teive HA Abstract BACKGROUND: Relapsing polychondritis is a rare multisystem disease characterized by bilateral auricular and nasal chondritis and vestibular involvement, additionally affecting various other organs/systems. However, Central Nervous System involvement has only been reported in a few instances. OBJECTIVE: To report the case of a patient with relapsing polychondritis and several neurological ma...περισσότερα »
New insights on PI3K/AKT pathway alterations and clinical outcomes in breast cancer.
*New insights on PI3K/AKT pathway alterations and clinical outcomes in breast cancer.* Cancer Treat Rev. 2016 Mar 9;45:87-96 Authors: Yang SX, Polley E, Lipkowitz S Abstract PI3K/AKT signaling pathway plays an important role in tumorigenesis and regulates critical cellular functions including survival, proliferation and metabolism. PIK3CA mutations and AKT activation by phosphorylation (pAKT) are often detected in many cancers and especially at high frequencies in breast cancer. Mounting data suggest that PIK3CA mutations or pAKT are mostly associated with better or insignificant...περισσότερα »
Personalized therapy for hepatocellular carcinoma: Where are we now?
*Personalized therapy for hepatocellular carcinoma: Where are we now?* Cancer Treat Rev. 2016 Mar 2;45:77-86 Authors: Chan SL, Wong AM, Lee K, Wong N, Chan AK Abstract Following the approval of sorafenib, a large number of molecular targeted agents have been tested clinically for advanced hepatocellular carcinoma (HCC), but all have failed to demonstrate significant efficacy in clinical trials. Multiple reasons for this phenomenon have been discussed in the literature, with one reason being the lack of patient selection on the basis of molecular profile in clinical trials. The con... περισσότερα »
Male breast cancer, clinical presentation, diagnosis and treatment: Twenty years of experience in our Breast Unit.
*Male breast cancer, clinical presentation, diagnosis and treatment: Twenty years of experience in our Breast Unit.* Int J Surg Case Rep. 2016 Feb 26; Authors: Sanguinetti A, Polistena A, Lucchini R, Monacelli M, Galasse S, Avenia S, Triola R, Bugiantella W, Cirocchi R, Rondelli F, Avenia N Abstract BACKGROUND: The male breast cancer (MBC) is a rare and represents less than 1% of all malignancies in men and only 1% of all breast cancers incident. We illustrate the experience of our team about the clinico-pathological characteristics, treatment and prognostic factors of patients tr... περισσότερα »
Personalized therapy for hepatocellular carcinoma: Where are we now?
*Personalized therapy for hepatocellular carcinoma: Where are we now?* Cancer Treat Rev. 2016 Mar 2;45:77-86 Authors: Chan SL, Wong AM, Lee K, Wong N, Chan AK Abstract Following the approval of sorafenib, a large number of molecular targeted agents have been tested clinically for advanced hepatocellular carcinoma (HCC), but all have failed to demonstrate significant efficacy in clinical trials. Multiple reasons for this phenomenon have been discussed in the literature, with one reason being the lack of patient selection on the basis of molecular profile in clinical trials. The con... περισσότερα »
Modified irinotecan and infusional 5-fluorouracil (mFOLFIRI) in patients with refractory advanced pancreas cancer (APC): a single-institution experience.
*Modified irinotecan and infusional 5-fluorouracil (mFOLFIRI) in patients with refractory advanced pancreas cancer (APC): a single-institution experience.* Med Oncol. 2016 Apr;33(4):37 Authors: Bupathi M, Ahn DH, Wu C, Ciombor KK, Stephens JA, Reardon J, Goldstein DA, Bekaii-Saab T Abstract Pancreatic adenocarcinoma is the fourth leading cause of cancer death. Recently, MM-398 (nanoliposomal irinotecan) was shown to be associated with significant improvement in outcome measures with acceptable toxicities when combined with 5-fluorouracil (5-FU)/leucovorin (LV) compared to 5-FU/LV...περισσότερα »
Tracking metastatic breast cancer: the future of biology in biosensors.
*Tracking metastatic breast cancer: the future of biology in biosensors.* Med Oncol. 2016 Apr;33(4):36 Authors: Lim YC, Wiegmans AP Abstract Circulating tumour cells associated with breast cancer (brCTCs) represent cells that have the capability to establish aggressive secondary metastatic tumours. The isolation and characterization of CTCs from blood in a single device is the future of oncology diagnosis and treatment. The methods of enrichment of CTCs have primarily utilized simple biological interactions with bimodal reporting with biased high purity and low numbers or low pur... περισσότερα »
Impact of dermatologic adverse events induced by targeted therapies on quality of life.
*Impact of dermatologic adverse events induced by targeted therapies on quality of life.* Crit Rev Oncol Hematol. 2016 Mar 5; Authors: Charles C, Bungener C, Razavi D, Mateus C, Routier E, Lanoy E, Verschoore M, Robert C, Dauchy S Abstract BACKGROUND: Investigations about the impact of dermatologic adverse events on quality of life in the context of targeted therapies are quite recent and results vary in some dimensions. This article aims to summarize the existing data and to clarify needs in terms of clinical management and future research. METHODS: A literature review was done ... περισσότερα »
Analysis of nodal coverage utilizing image guided radiation therapy for primary gynecologic tumor volumes.
*Analysis of nodal coverage utilizing image guided radiation therapy for primary gynecologic tumor volumes.* Med Dosim. 2016 Mar 16; Authors: Ahmed F, Sarkar V, Gaffney DK, Salter B, Poppe MM Abstract PURPOSE: To evaluate radiation dose delivered to pelvic lymph nodes, if daily Image Guided Radiation Therapy (IGRT) was implemented with treatment shifts based on the primary site (primary clinical target volume [CTV]). Our secondary goal was to compare dosimetric coverage with patient outcomes. MATERIALS AND METHODS: A total of 10 female patients with gynecologic malignancies were e...περισσότερα »
Simple shielding reduces dose to the contralateral breast during prone breast cancer radiotherapy.
*Simple shielding reduces dose to the contralateral breast during prone breast cancer radiotherapy.* Med Dosim. 2016 Mar 16; Authors: Goyal U, Locke A, Smith-Raymond L, Georgiev GN Abstract Our goal was to design a prone breast shield for the contralateral breast and study its efficacy in decreasing scatter radiation to the contralateral breast in a prone breast phantom setup receiving radiation therapy designed for breast cancer. We constructed a prone breast phantom setup consisting of (1) A thermoplastic mask with a left-sided depression created by a water balloon for a breast... περισσότερα »
Clinical Challenge: An Orbital Hickam's Dictum.
*Clinical Challenge: An Orbital Hickam's Dictum.* Surv Ophthalmol. 2016 Mar 16; Authors: Wilson ME, Thornton S, Murchison AP, Bilyk JR Abstract A 53-year old man with hyperthyroidism presented with asymmetric proptosis and diplopia. Thyroid stimulating immunoglobulin was elevated, suggesting active thyroid eye disease (TED). Imaging of the orbits revealed enlargement of the extraocular muscles including irregular enlargement of the left lateral rectus muscle. Biopsy of the lateral rectus muscle demonstrated infiltration of the muscle with Bcl-2 positive B lymphocytes, consistent ...περισσότερα »
Comparison of Nasal Septum and Ear Cartilage as a Graft for Lower Eyelid Reconstruction.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Comparison of Nasal Septum and Ear Cartilage as a Graft for Lower Eyelid Reconstruction.* J Craniofac Surg. 2016 Mar;27(2):305-7 Authors: Suga H, Ozaki M, Narita K, Kurita M, Shiraishi T, Ohura N, Takushima A, Harii K Abstract In lower eyelid reconstruction, several types of grafts from the nasal septum, ear cartilage, buccal mucosa, and hard palate mucosa have been used for an inner layer of the lower eyelid, but there have been no studies comparing these grafts. The authors retrospectively reviewed our cases of... περισσότερα »
In defence of transpalatal, transpalatal-circumaxillary (transpterygopalatine) and transpalatal-circumaxillary-sublabial approaches to lateral extensions of juvenile nasopharyngeal angiofibroma.
Related Articles *In defence of transpalatal, transpalatal-circumaxillary (transpterygopalatine) and transpalatal-circumaxillary-sublabial approaches to lateral extensions of juvenile nasopharyngeal angiofibroma.* J Laryngol Otol. 2016 Mar 4;:1-12 Authors: Mishra A, Mishra SC, Verma V, Singh HP, Kumar S, Tripathi AM, Patel B, Singh V Abstract BACKGROUND: Juvenile nasopharyngeal angiofibroma often presents with lateral extensions. In countries with limited resources, selection of a cost-effective and least morbid surgical approach for complete excision is challenging. METHODS: Si... περισσότερα »
Middle ear findings and need for ventilation tubes among pediatric cleft lip and palate patients in northern Finland.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Middle ear findings and need for ventilation tubes among pediatric cleft lip and palate patients in northern Finland.* J Craniomaxillofac Surg. 2016 Jan 11; Authors: Lehtonen V, Lithovius RH, Autio TJ, Sándor GK, Ylikontiola LP, Harila V, Pesonen P, Koskinen S, Anttonen V Abstract PURPOSE: Middle ear problems are common in cleft patients. This study aimed to determine the need for ventilation tubes (VTs) and complications such as tympanic perforation and cholesteatoma. MATERIAL AND METHODS: Data of 156 children wi... περισσότερα »
Management of a cocaine-induced palatal perforation with a nasal septal button.
Related Articles *Management of a cocaine-induced palatal perforation with a nasal septal button.* Ear Nose Throat J. 2016 Jan;95(1):E36-8 Authors: Trimarchi M, Sykopetrites V, Bussi M Abstract A cocaine-induced midline destructive lesion (CIMDL) is a rare consequence of cocaine insufflation that involves the nose, sinuses, and occasionally the palate. Palatal perforations compromise swallowing, mastication, and speech. An obturator prosthesis can be used to overcome these complications. In selected cases, a nasal septal button is a good alternative for the sealing of a palatal ... περισσότερα »
Using frogs faces to dissect the mechanisms underlying human orofacial defects.
Related Articles *Using frogs faces to dissect the mechanisms underlying human orofacial defects.* Semin Cell Dev Biol. 2016 Mar;51:54-63 Authors: Dickinson AJ Abstract In this review I discuss how Xenopus laevis is an effective model to dissect the mechanisms underlying orofacial defects. This species has been particularly useful in studying the understudied structures of the developing face including the embryonic mouth and primary palate. The embryonic mouth is the first opening between the foregut and the environment and is critical for adult mouth development. The final ste... περισσότερα »
CHST14/D4ST1 deficiency: New form of Ehlers-Danlos syndrome.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *CHST14/D4ST1 deficiency: New form of Ehlers-Danlos syndrome.* Pediatr Int. 2016 Feb;58(2):88-99 Authors: Kosho T Abstract Carbohydrate sulfotransferase 14/dermatan 4-O-sulfotransferase-1 (CHST14/D4ST1) deficiency represents a specific form of Ehlers-Danlos syndrome (EDS) caused by recessive loss-of-function mutations in CHST14. The disorder has been independently termed "adducted thumb-clubfoot syndrome", "EDS, Kosho type", and "EDS, musculocontractural type". To date, 31 affected patients from 21 families have b...περισσότερα »
Relationship of central incisor implant placement to the ridge configuration anterior to the nasopalatine canal in dentate and partially edentulous individuals: a comparative study.
[image: https:--d2pdyyx74uypu5.cloudfront.net-im] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Relationship of central incisor implant placement to the ridge configuration anterior to the nasopalatine canal in dentate and partially edentulous individuals: a comparative study.* PeerJ. 2015;3:e1315 Authors: Jia X, Hu W, Meng H Abstract Background. The aims of this study were to investigate the ridge contour anterior to the nasopalatine canal, and the difference between the incidences of the nasopalatine canal perforation in dentate and partially edentulous patients by c... περισσότερα »
A Surgical Technique for the Management of Suction Cup-Induced Palatal Perforation: A Technical Note.
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *A Surgical Technique for the Management of Suction Cup-Induced Palatal Perforation: A Technical Note.* J Clin Diagn Res. 2015 Jul;9(7):ZD20-1 Authors: Rahpeyma A, Khajehahmadi S Abstract Suction cap-induced palatal perforation is uncommon today. In the surgical management of such a complication, the surgeon should consider the large bony defect hidden behind the small slit in the palatal mucosa. In this article a case is presented,in which a combination of anteriorly based inferior turbinate flap and posteriorly based palata... περισσότερα »
Squamous cell carcinoma on a syphilitic gumma: A unique presentation.
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Squamous cell carcinoma on a syphilitic gumma: A unique presentation.* Indian J Sex Transm Dis. 2015 Jan-Jun;36(1):89-91 Authors: Rahima S, Riyaz N, Latheef EN, Shyni PM Abstract Gumma is a characteristic lesion of tertiary syphilis that is rare nowadays, but still rarer is squamous cell carcinoma (SCC) arising from it. A 74-year-old male presented with throat pain and nasal twang with a past history of genital ulcer. Examination revealed a well-defined ulcer with a perforation of 1.5 cm over the hard palate with induration a... περισσότερα »
A Hemophagocytic Lymphohistiocytosis Case with Newly Defined UNC13D (c.175G>C; p.Ala59Pro) Mutation and a Rare Complication.
Related Articles *A Hemophagocytic Lymphohistiocytosis Case with Newly Defined UNC13D (c.175G>C; p.Ala59Pro) Mutation and a Rare Complication.* Turk J Haematol. 2015 Dec 5;32(4):355-358 Authors: Balcı YI, Özgürler Akpınar F, Polat A, Kenar F, Tesi B, Greenwood T, Yalçın N, Koçyiğit A Abstract Hemophagocytic lymphohistiocytosis (HLH) represents a severe hyperinflammatory condition with cardinal symptoms of prolonged fever, cytopenias, hepatosplenomegaly, and hemophagocytosis by activated, morphologically benign macrophages with impaired function of natural killer cells and cytoto... περισσότερα »
Radiographic study of the problems and failures of endodontic treatment.
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Radiographic study of the problems and failures of endodontic treatment.* Int J Health Sci (Qassim). 2015 Apr;9(2):111-8 Authors: Akbar I Abstract OBJECTIVES: The aim of the present study was to determine radiographically the different reasons and problems of endodontic treatment failure. METHODS: The periapical radiographs of 100 patients with one hundred teeth (130 root canals) were examined to identify the problems and failures of endodontic treatment. The various reasons of failure that is under filling, poor filling, ove... περισσότερα »
CLINICAL PATHOLOGIC CONFERENCE CASE 2: PALATAL PERFORATION.
Related Articles *CLINICAL PATHOLOGIC CONFERENCE CASE 2: PALATAL PERFORATION.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Jun;119(6):e292-5 Authors: Dovigi A, Natarajan E PMID: 26153584 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1XGOIwE via IFTTT
Radiation-induced brain necrosis : Single-fraction versus multi-fraction (3 x 9 Gy) stereotactic radiosurgery for large (> 2 cm) brain metastases
: a comparative analysis of local control and risk of radiation-induced brain necrosis via International Journal of Radiation Oncology*Biology*Physics Publication date: Available online 19 March 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics Author(s): Giuseppe Minniti, Claudia Scaringi, Sergio Paolini, Gaetano Lanzetta, Andrea Romano, Francesco Cicone, Mattia Osti, Riccardo Maurizi Enrici, Vincenzo Esposito Purposeto investigate the factors affecting local control and radiation-induced brain necrosis in patients with brain metastases >2 cm in size who receiv...περισσότερα »
Serum cathepsin B and D in patients with nasopharyngeal carcinoma
Diagnostic values of serum cathepsin B and D in patients with nasopharyngeal carcinoma: Abstract BackgroundThe diagnostic and prognostic significance of increased cathepsin B (CTSB) and cathepsin D (CTSD) concentration in the serum of cancer patients were evaluated for some tumor types. High expression of CTSD and CTSB was detected in biopsy tissues from nasopharyngeal carcinoma (NPC). However, whether CTSD and CTSB serve as diagnostic and prognostic markers of NPC remains unclear. MethodsSerum samples were collected from 40 healthy volunteers and 80 NPC patients enrolled in t... περισσότερα »
The Longitudinal Outcomes of Children with Hearing Impairment (LOCHI)
LOCHI Reaches Phase II Trials: Researchers from the HEARing Cooperative Research Center (HEARing CRC) in Australia recently completed testing all 5-year-olds in the Longitudinal Outcomes of Children with Hearing Impairment (LOCHI) study and are on their way to completing their 9-year-old assessments. The LOCHI study has so far found that infants with hearing loss who are fitted with hearing aids and cochlear implants as soon as possible have better language and learning abilities. The study is in its 11th year and has assessed more than 400 children with hearing loss at 6 and 12 m... περισσότερα »
Inherent envelope fluctuations in forward maskers: Effects of masker-probe delay for listeners with normal and impaired hearing
Inherent envelope fluctuations in forward maskers: Effects of masker-probe delay for listeners with normal and impaired hearinga): [image: cm_sbs_024_plain.png] Forward-masked thresholds increase as the magnitude of inherent masker envelope fluctuations increase for both normal-hearing (NH) and hearing-impaired (HI) adults for a short masker-probe delay (25 ms). The slope of the recovery from forward masking is shallower for HI than for NH listeners due to reduced cochlear nonlinearities. However, effects of hearing loss on additional masking due to inherent envelope fluctuations ... περισσότερα »
40-Hz Sinusoidal Auditory Steady-State Response and Tone Burst Auditory Brainstem Response Using a Kalman Filter to Determine Thresholds Pre- and Post-Myringotomy With Grommet Tube in Children With Mild, Low-Frequency Conductive Hearing Loss
40-Hz Sinusoidal Auditory Steady-State Response and Tone Burst Auditory Brainstem Response Using a Kalman Filter to Determine Thresholds Pre- and Post-Myringotomy With Grommet Tube in Children With Mild, Low-Frequency Conductive Hearing Loss: Purpose Accurate estimation of mild, low-frequency hearing loss is difficult in young children. This study aimed to determine the accuracy of 40-Hz sinusoidal auditory steady-state response (sASSR) compared with tone burst auditory brainstem response (TB-ABR) to detect mild, low-frequency hearing loss in children with otitis media with effusio...περισσότερα »
Phoneme and Word Scoring in Speech-in-Noise Audiometry
Phoneme and Word Scoring in Speech-in-Noise Audiometry: Purpose Understanding speech in background noise is difficult for many individuals; however, time constraints have limited its inclusion in the clinical audiology assessment battery. Phoneme scoring of words has been suggested as a method of reducing test time and variability. The purposes of this study were to establish a phoneme scoring rubric and use it in testing phoneme and word perception in noise in older individuals and individuals with hearing impairment. Method Words were presented to 3 participant groups at 80 dB i... περισσότερα »
Facioaudiosymphalangism syndrome without hearing loss
Further delineation of facioaudiosymphalangism syndrome: Description of a family with a novel NOG mutation and without hearing loss.: *Further delineation of facioaudiosymphalangism syndrome: Description of a family with a novel NOG mutation and without hearing loss.* Am J Med Genet A. 2016 Mar 20; Authors: Bayat A, Fijalkowski I, Andersen T, Azhar Abdulmunem S, van den Ende J, Van Hul W Abstract Mutations in the NOG gene give rise to a wide range of clinical phenotypes. Noggin, the protein encoded by this gene is a secreted modulator of multiple pathways involved in both bone an... περισσότερα »
A novel NOG mutation and without hearing loss
Further delineation of facioaudiosymphalangism syndrome: Description of a family with a novel NOG mutation and without hearing loss.: Am J Med Genet A. 2016 Mar 20; Authors: Bayat A, Fijalkowski I, Andersen T, Azhar Abdulmunem S, van den Ende J, Van Hul W Abstract Mutations in the NOG gene give rise to a wide range of clinical phenotypes. Noggin, the protein encoded by this gene is a secreted modulator of multiple pathways involved in both bone and joint development. Proximal symphalangism is commonly observed in patients bearing mutations in this gene, however secondary symptomes... περισσότερα »
New content published in February 2016
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 42 δευτερόλεπτα
[image: BioMed Central – The Open Access Publisher] Genome Biology Impact Factor: 10.800 Genome Biology Impact Factor: 10.800 Submit Manuscript | Editorial Board | submission guidelines | Article Alerts Dear Dr Sfakianakis, We are pleased to share with you our February content update. Featuring journal news, top articles and our most recent table of contents. ------------------------------ Journal News Call For Papers: Special Issue on the Genomics of Rare and Common Diseases Guest edited by *Daniel MacArthur* and *Mark McCarthy.* We have launched a n... περισσότερα »
Acute health problems due to recreational drug use in patients presenting to an urban emergency department in Switzerland
QUESTIONS UNDER STUDY: To describe acute toxicity of recreational drugs including novel psychoactive substances. METHODS: We included all cases presenting at the emergency department (ED) of the University Hospital of Basel, Switzerland, between October 2013 and September 2014 with acute toxicity due to self-reported recreational drug use or with symptoms/signs consistent with acute toxicity. Isolated… Continue reading Acute health problems due to recreational drug use in patients presenting to an urban emergency department in Switzerland
How I do it: modified Todd’s meatoplasty
Rapid Communication A N Elsamanody, V Topsakal, W Grolman, R A Tange The Journal of Laryngology & Otology,FirstView Article(s), 4 pages Abstract from ! ORL via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ZjC4Fc via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ScIjaR via IFTTT
Evaluation of drug incorporation into hair segments and nails by enantiomeric analysis following controlled single MDMA intakes
Incorporation rates of the enantiomers of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA) into hair and nails were investigated after controlled administration. Fifteen subjects without MDMA use received two doses of 125 mg of MDMA. Hair, nail scrapings, and nail clippings were collected 9-77 days after the last administration (median 20 days). Hair samples were… Continue reading Evaluation of drug incorporation into hair segments and nails by enantiomeric analysis following controlled single MDMA intakes
No breakpoint for mortality in pediatric rib fractures
BACKGROUND: Rib fracture number correlates with mortality in adult trauma patients, sharply rising above six fractured ribs. Because of the pliability of younger ribs, pediatric ribs are believed to require more energy to fracture. We hypothesized this will result in a different rib fracture–associated pediatric mortality rate. METHODS: We queried the National Trauma Data Bank… Continue reading No breakpoint for mortality in pediatric rib fractures
Stress-induced in vivo recruitment of human cytotoxic natural killer cells favors subsets with distinct receptor profiles and associates with increased epinephrine levels
Acute stress drives a ‘high-alert’ response in the immune system. Psychoactive drugs induce distinct stress hormone profiles, offering a sought-after opportunity to dissect the in vivo immunological effects of acute stress in humans. 3,4-methylenedioxymethamphetamine (MDMA), methylphenidate (MPH), or both, were administered to healthy volunteers in a randomized, double-blind, placebo-controlled crossover-study. Lymphocyte subset frequencies, natural killer… Continue reading Stress-induced in vivo recruitment of human cytotoxic natural killer cells favors subsets with distinct recept... περισσότερα »
IJMS, Vol. 17, Pages 398: Antiallergic Phorbol Ester from the Seeds of Aquilaria malaccensis
The Aquilaria malaccensis (Thymelaeaceae) tree is a source of precious fragrant resin, called agarwood, which is widely used in traditional medicines in East Asia against diseases such as asthma. In our continuous search for active natural products, A. malaccensis seeds ethanolic extract demonstrated antiallergic effect with an IC50 value less than 1 µg/mL. Therefore, the… Continue reading IJMS, Vol. 17, Pages 398: Antiallergic Phorbol Ester from the Seeds of Aquilaria malaccensis
Seven day services: how relevant is the ȷunior doctors’ contract?
Gulland’s article provides an interesting perspective on the trusts held up as shining examples by Hunt in pushing through the seven day services agenda.1 The policy has repeatedly been used as an… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1XH3XFH via IFTTT
US researchers blocked from testing Cuban drug
The ongoing US blockade of Cuba is preventing US researchers from studying a drug they say is highly promising and could reduce the need for amputations caused by diabetic foot ulcers.The drug, human… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1VuDHQv via IFTTT
DRG-Erlösen pro Op-Minute – ein Kalkulationsleitfaden
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Berechnung des Mythos Die wirtschaftliche Situation in deutschen Krankenhäusern ist angespannt und erfordert differenzierte Steuerungsinstrumente. Dazu gehören Kennzahlen zur Erlösentwicklung der verschiedenen Organisationseinheiten eines Krankenhauses. Der OP als Hocherlös- und Hochkostenbereich ist davon besonders betroffen. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1WCgJVQ via IFTTT
Frontiers of Possession: Spain and Portugal in Europe and the Americas, Tamar Herzog. Cambridge, Harvard University Press (2014)
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Publication date: Available online 20 March 2016 Source:Journal of Historical Geography Author(s): Fabrício Prado from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UxwRtY via IFTTT
DRG-Erlösen pro Op-Minute – ein Kalkulationsleitfaden
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Berechnung des Mythos Die wirtschaftliche Situation in deutschen Krankenhäusern ist angespannt und erfordert differenzierte Steuerungsinstrumente. Dazu gehören Kennzahlen zur Erlösentwicklung der verschiedenen Organisationseinheiten eines Krankenhauses. Der OP als Hocherlös- und Hochkostenbereich ist davon besonders betroffen. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1WCgJVQ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Frontiers of Possession: Spain and Portugal in Europe and the Americas, Tamar Herzog. Cambridge, Harvard University Press (2014)
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Publication date: Available online 20 March 2016 Source:Journal of Historical Geography Author(s): Fabrício Prado from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UxwRtY via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Acute health problems due to recreational drug use in patients presenting to an urban emergency department in Switzerland
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
QUESTIONS UNDER STUDY: To describe acute toxicity of recreational drugs including novel psychoactive substances. METHODS: We included all cases presenting at the emergency department (ED) of the University Hospital of Basel, Switzerland, between October 2013 and September 2014 with acute toxicity due to self-reported recreational drug use or with symptoms/signs consistent with acute toxicity. Isolated […]
Evaluation of drug incorporation into hair segments and nails by enantiomeric analysis following controlled single MDMA intakes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Incorporation rates of the enantiomers of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA) into hair and nails were investigated after controlled administration. Fifteen subjects without MDMA use received two doses of 125 mg of MDMA. Hair, nail scrapings, and nail clippings were collected 9-77 days after the last administration (median 20 days). Hair samples were […]
Stress-induced in vivo recruitment of human cytotoxic natural killer cells favors subsets with distinct receptor profiles and associates with increased epinephrine levels
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Acute stress drives a ‘high-alert’ response in the immune system. Psychoactive drugs induce distinct stress hormone profiles, offering a sought-after opportunity to dissect the in vivo immunological effects of acute stress in humans. 3,4-methylenedioxymethamphetamine (MDMA), methylphenidate (MPH), or both, were administered to healthy volunteers in a randomized, double-blind, placebo-controlled crossover-study. Lymphocyte subset frequencies, natural killer […]
Before retinal cells die, they regenerate, Penn vet blindness study finds
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 47 δευτερόλεπτα
Until relatively recently, the dogma in neuroscience was that neurons, including the eye’s photoreceptor cells, rods and cones, do not regenerate. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R9VJp7 via IFTTT
Differential regional responsiveness of astroglia in mild hepatic encephalopathy: An Immunohistochemical approach in bile duct ligated rat.
*Differential regional responsiveness of astroglia in mild hepatic encephalopathy: An Immunohistochemical approach in bile duct ligated rat.* Acta Histochem. 2016 Mar 16; Authors: Hiba OE, Elgot A, Ahboucha S, Gamrani H Abstract Hepatic encephalopathy (HE) is a neuropsychiatric disorder that occurs in both acute and chronic liver failure. However, the pathomechanisms of the disease remains obscure. Neuropathological studies have demonstrated a primary gliopathy in humans as well as in animal models of chronic and acute liver failure. Here, we have investigated in an animal model o...περισσότερα »
Drug Safety, Vol. 39, Issue 4 - New Issue Alert
If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 03/21/2016 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *Drug Safety*. Volume 39 Number 4 is now available online. In this issue Editorial Vulnerable Patients and Potential Harms: The Contribution of Observational Research Deborah Layton » Abstract » Full text HTML » Full text PDF Current Opinion Pharmacovigilance is … Vigilance I. Ralph Edwards & Rachida Soulayamani Bencheikh » Abstract » Full text ... περισσότερα »
A Histomorphological Pattern Analysis of Pulmonary Tuberculosis in Lung Autopsy and Surgically Resected Specimens
Background. Tuberculosis (TB) is a major cause of morbidity and mortality globally. Many cases are diagnosed on autopsy and a subset of patients may require surgical intervention either due to the complication or sequelae of TB. Materials and Methods. 40 cases of resected lung specimens following surgery or autopsy in which a diagnosis of pulmonary tuberculosis was made were included. Histopathological pattern analysis of pulmonary tuberculosis along with associated nonneoplastic changes and identification of Mycobacterium tuberculosis bacilli was done. Results. The mean age of di... περισσότερα »
A third-person perspective on co-speech action gestures in Parkinson's disease.
*A third-person perspective on co-speech action gestures in Parkinson's disease.* Cortex. 2016 Feb 27;78:44-54 Authors: Humphries S, Holler J, Crawford TJ, Herrera E, Poliakoff E Abstract A combination of impaired motor and cognitive function in Parkinson's disease (PD) can impact on language and communication, with patients exhibiting a particular difficulty processing action verbs. Co-speech gestures embody a link between action and language and contribute significantly to communication in healthy people. Here, we investigated how co-speech gestures depicting actions are affect... περισσότερα »
Structural and functional changes of cortical and subcortical structures following peripheral vestibular damage in humans.
*Structural and functional changes of cortical and subcortical structures following peripheral vestibular damage in humans.* Eur Arch Otorhinolaryngol. 2016 Mar 19; Authors: Maxime M, Philippe F, Landry SP, François C, Saliba I PMID: 26994901 [PubMed - as supplied by publisher] from Speech via xlomafota13 on Inoreader http://ift.tt/1XGLoRW
Ultrasound visual feedback in articulation therapy following partial glossectomy.
*Ultrasound visual feedback in articulation therapy following partial glossectomy.* J Commun Disord. 2016 Mar 2;61:1-15 Authors: Blyth KM, Mccabe P, Madill C, Ballard KJ Abstract Disordered speech is common following treatment for tongue cancer, however there is insufficient high quality evidence to guide clinical decision making about treatment. This study investigated use of ultrasound tongue imaging as a visual feedback tool to guide tongue placement during articulation therapy with two participants following partial glossectomy. A Phase I multiple baseline design across behav... περισσότερα »
Deficits in voice and multisensory processing in patients with Prader-Willi syndrome.
*Deficits in voice and multisensory processing in patients with Prader-Willi syndrome.* Neuropsychologia. 2016 Mar 16; Authors: Salles J, Strelnikov K, Carine M, Denise T, Laurier V, Molinas C, Tauber M, Barone P Abstract Prader-Willi syndrome (PWS) is a rare neurodevelopmental and genetic disorder that is characterized by various expression of endocrine, cognitive and behavioral problems, among which a true obsession for food and a deficit of satiety that leads to hyperphagia and severe obesity. Neuropsychological studies have reported that PWS display altered social interactio...περισσότερα »
Acute health problems due to recreational drug use in patients presenting to an urban emergency department in Switzerland
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
QUESTIONS UNDER STUDY: To describe acute toxicity of recreational drugs including novel psychoactive substances. METHODS: We included all cases presenting at the emergency department (ED) of the University Hospital of Basel, Switzerland, between October 2013 and September 2014 with acute toxicity due to self-reported recreational drug use or with symptoms/signs consistent with acute toxicity. Isolated […]
Evaluation of drug incorporation into hair segments and nails by enantiomeric analysis following controlled single MDMA intakes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Incorporation rates of the enantiomers of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA) into hair and nails were investigated after controlled administration. Fifteen subjects without MDMA use received two doses of 125 mg of MDMA. Hair, nail scrapings, and nail clippings were collected 9-77 days after the last administration (median 20 days). Hair samples were […]
Stress-induced in vivo recruitment of human cytotoxic natural killer cells favors subsets with distinct receptor profiles and associates with increased epinephrine levels
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Acute stress drives a ‘high-alert’ response in the immune system. Psychoactive drugs induce distinct stress hormone profiles, offering a sought-after opportunity to dissect the in vivo immunological effects of acute stress in humans. 3,4-methylenedioxymethamphetamine (MDMA), methylphenidate (MPH), or both, were administered to healthy volunteers in a randomized, double-blind, placebo-controlled crossover-study. Lymphocyte subset frequencies, natural killer […]
Before retinal cells die, they regenerate, Penn vet blindness study finds
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Until relatively recently, the dogma in neuroscience was that neurons, including the eye’s photoreceptor cells, rods and cones, do not regenerate. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R9VJp7 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
How I do it: modified Todd’s meatoplasty
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Rapid Communication A N Elsamanody, V Topsakal, W Grolman, R A Tange The Journal of Laryngology & Otology,FirstView Article(s), 4 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ZjC4Fc via IFTTT
Hypoxia enhances angiogenesis in an adipose-derived stromal cell/endothelial cell co-culture 3D gel model
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objectives This study aimed to investigate the influence of hypoxia on angiogenesis in a 3D gel, with co-culturing adipose-derived stromal cells (ASCs) and endothelial cells (ECs). Materials and methods ASCs from green fluorescent protein-labeled mice and ECs from red fluorescent protein-labeled mice were co-cultured in 3D collagen gels at 1:1 ratio, in normal and […]
Individual and Familial Susceptibility to MPTP in a Common Marmoset Model for Parkinson’s Disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Introduction: Insight into susceptibility mechanisms underlying Parkinson’s disease (PD) would aid the understanding of disease etiology, enable target finding and benefit the development of more refined disease-modifying strategies. Methods: We used intermittent low-dose MPTP (0.5 mg/kg/week) injections in marmosets and measured multiple behavioral and neurochemical parameters. Genetically diverse monkeys from different breeding families were selected […]
Condensin in Chromatid Cohesion and Segregation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
After replication of genomic DNA during the S phase, 2 chromatids hold together longitudinally. When cells enter mitosis, the paired sister chromatids start to condense and then segregate into individual chromatids except for the centromeric region. Upon attachment of microtubules to the kinetochore, subsequent pulling of the 2 sister chromatids by the spindles towards opposite […]
How I do it: modified Todd’s meatoplasty
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Rapid Communication A N Elsamanody, V Topsakal, W Grolman, R A Tange The Journal of Laryngology & Otology,FirstView Article(s), 4 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ZjC4Fc via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Hypoxia enhances angiogenesis in an adipose-derived stromal cell/endothelial cell co-culture 3D gel model
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objectives This study aimed to investigate the influence of hypoxia on angiogenesis in a 3D gel, with co-culturing adipose-derived stromal cells (ASCs) and endothelial cells (ECs). Materials and methods ASCs from green fluorescent protein-labeled mice and ECs from red fluorescent protein-labeled mice were co-cultured in 3D collagen gels at 1:1 ratio, in normal and […]
Expanded phenotypic spectrum of the m.8344A>G "MERRF" mutation: data from the German mitoNET registry.
*Expanded phenotypic spectrum of the m.8344A>G "MERRF" mutation: data from the German mitoNET registry.* J Neurol. 2016 Mar 19; Authors: Altmann J, Büchner B, Nadaj-Pakleza A, Schäfer J, Jackson S, Lehmann D, Deschauer M, Kopajtich R, Lautenschläger R, Kuhn KA, Karle K, Schöls L, Schulz JB, Weis J, Prokisch H, Kornblum C, Claeys KG, Klopstock T Abstract The m.8344A>G mutation in the MTTK gene, which encodes the mitochondrial transfer RNA for lysine, is traditionally associated with myoclonic epilepsy and ragged-red fibres (MERRF), a multisystemic mitochondrial disease that is cha... περισσότερα »
Surgical treatment of substernal goiter: An analysis of 44 cases.
*Surgical treatment of substernal goiter: An analysis of 44 cases.* Auris Nasus Larynx. 2016 Mar 16; Authors: Nakaya M, Ito A, Mori A, Oka M, Omura S, Kida W, Inayoshi Y, Inoue A, Fuchigami T Abstract OBJECTIVE: Substernal goiters are classified as primary or secondary intrathoracic goiters. Here, we report the diagnosis, symptoms, treatment, and postoperative complications of 44 substernal goiters (2 primary mediastinal goiter and 42 secondary mediastinal goiters). METHODS: A retrospective chart review of 351 patients undergoing thyroidectomy at the Department of Otolaryngology-H...περισσότερα »
Validation of a reading assessment for persons with homonymous hemianopia and quadrantanopia
Archives of Physical Medicine and Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1o19sTC via IFTTT
Impact of the US Food and Drug Administration's Safety-Related Announcements on the Use of Bisphosphonates after Hip Fracture
Journal of Bone and Mineral Research from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1pWwpsE via IFTTT
Outcomes following external iliac and femoral vascular injuries
Annals of Vascular Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1o19qLq via IFTTT
End-tidal carbon dioxide monitoring and load band device for mechanical cardio-pulmonary resuscitation: Never trust the numbers, believe at the curves
Resuscitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1pWwpsw via IFTTT
Prevention and control of carbapenemase-producing organisms at a regional burns centre
Journal of Hospital Infection from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1o19qLk via IFTTT
Aspects of posttraumatic stress disorder in long-term testicular cancer survivors: cross-sectional and longitudinal findings
Journal of Cancer Survivorship from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1pWwpcc via IFTTT
Greater fall risk in elderly women than in men is associated with increased gait variability during multitasking
Journal of the American Medical Directors Association from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1o19qv0 via IFTTT
The association between neighborhood effects and out-of-hospital cardiac arrest outcomes
Resuscitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1pWwrRm via IFTTT
Visual acuity measured with a smartphone app is more accurate than snellen testing by emergency department providers
Graefe's Archive for Clinical and Experimental Ophthalmology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1o19pXQ via IFTTT
The optic nerve sheath diameter as a useful tool for early prediction of outcome after cardiac arrest: A prospective pilot study
Resuscitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1pWwpc6 via IFTTT
Targeting frequent users of emergency departments: Prominent risk factors and policy implications
Health Policy from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1o19pXI via IFTTT
Epidemiology of meniscal injuries in US high school athletes between 2007 and 2013
Knee Surgery, Sports Traumatology, Arthroscopy from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1pWwrRe via IFTTT
Clinical implications of assisted peak cough flow measured with external glottic control device for tracheostomy decannulation in the patients with neuromuscular diseases and cervical spinal cord injuries: a pilot study
Archives of Physical Medicine and Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1o19quL via IFTTT
Re-exposure to the hypobaric hypoxic brain injury of high altitude: plasma S100B levels and the possible effect of acclimatisation on blood-brain barrier dysfunction
Neurological Sciences from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1pWwpbX via IFTTT
Individual responses to a barefoot running program: insight into risk of injury
The American Journal of Sports Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1o19pHp via IFTTT
The effects of an injury prevention program on landing biomechanics over time
The American Journal of Sports Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1pWwoVF via IFTTT
Emergent reversal of vitamin K antagonists: Addressing all the factors
The American Journal of Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1o19pHf via IFTTT
Missed opportunities to keep children safe? National survey of injury prevention activities of children’s centres
Health Education Journal from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1pWwrAF via IFTTT
Haploidentical versus Matched-Sibling Transplant in Adults With Philadelphia-negative high-risk Acute Lymphoblastic Leukemia: A biologically phase 3 randomized study
Clinical Cancer Research from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1o19pqT via IFTTT
Prevalence and risk factors of postoperative delirium in elderly hip fracture patients
The Journal of International Medical Research from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1pWwoF9 via IFTTT
Meso-mono-4-(1,4,7-triazacyclononanyl)-tri(phenyl)]porphyrin and respective zinc(II)-complex: complete characterization and biomolecules binding abilities
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Photochem. Photobiol. Sci., 2016, Accepted Manuscript DOI: 10.1039/C6PP00016A, Paper Bruna L. Auras, Vanessa A. Oliveira, Hernan Terenzi, Ademir Neves, Bernardo Almeida Iglesias We aimed to synthesize a new series of triazacyclononanyl-porphyrins (4 and 5) with the potential ability to bind DNA. For that, the free-base porphyrin 4 and the corresponding Zn(II)-complex 5… The content of […]
How I do it: modified Todd’s meatoplasty
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Rapid Communication A N Elsamanody, V Topsakal, W Grolman, R A Tange The Journal of Laryngology & Otology,FirstView Article(s), 4 pages Abstract from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ZjC4Fc via IFTTT
Hypoxia enhances angiogenesis in an adipose-derived stromal cell/endothelial cell co-culture 3D gel model
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objectives This study aimed to investigate the influence of hypoxia on angiogenesis in a 3D gel, with co-culturing adipose-derived stromal cells (ASCs) and endothelial cells (ECs). Materials and methods ASCs from green fluorescent protein-labeled mice and ECs from red fluorescent protein-labeled mice were co-cultured in 3D collagen gels at 1:1 ratio, in normal and […]
Condensin in Chromatid Cohesion and Segregation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
After replication of genomic DNA during the S phase, 2 chromatids hold together longitudinally. When cells enter mitosis, the paired sister chromatids start to condense and then segregate into individual chromatids except for the centromeric region. Upon attachment of microtubules to the kinetochore, subsequent pulling of the 2 sister chromatids by the spindles towards opposite […]
Rewarded visual items capture attention only in heterogeneous contexts
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Reward is known to affect visual search performance. Rewarding targets can increase search performance, whereas rewarding distractors can decrease search performance. We used subcomponents of the N2pc in the event-related EEG, the NT (target negativity) and ND/PD (distractor negativity/positivity), in a visual search task to disentangle target and distractor processing related to reward. The […]
One-year developmental stability and covariance among oddball, novelty, go/no-go, and flanker event-related potentials in adolescence: A monozygotic twin study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract ERP measures may index genetic risk for psychopathology before disorder onset in adolescence, but little is known about their developmental rank-order stability during this period of significant brain maturation. We studied ERP stability in 48 pairs of identical twins (age 14–16 years) tested 1 year apart. Trial-averaged voltage waveforms were extracted from electroencephalographic recordings […]
The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-in flammatory … – Nature.com
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory … Nature.com … the cytokine interleukin-6 and the chemokine CCL2. We propose that Δ122p53 (and Δ133p53) acts in a similar manner to ‘gain-of-function’ mutant p53 proteins to promote migration, invasion and metastasis, which may contribute to poor survival in … from […]
Head and neck cancer patients invited to join Plymouth group – Plymouth Herald
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Head and neck cancer patients invited to join Plymouth group Plymouth Herald PLYMOUTH Laryngectomy Club (PLC) members met up at The Mustard Tree Cancer Support Centre on Monday, March 7 at for tea/coffee at 10.30am. The programme included a 30-min talk/presentation by Venita Botha, a Reiki therapist working out of The … from #AlexandrosSfakianakis via […]
Human Neural Stem Cells Overexpressing Choline Acetyltransferase Restore Unconditioned Fear in Rats with Amygdala Injury
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Amygdala is involved in the fear memory that recognizes certain environmental cues predicting threatening events. Manipulation of neurotransmission within the amygdala affects the expression of conditioned and unconditioned emotional memories such as fear freezing behaviour. We previously demonstrated that F3.ChAT human neural stem cells (NSCs) overexpressing choline acetyltransferase (ChAT) improve cognitive function of Alzheimer’s disease […]
Designing Unimodular Waveform with Low Range Sidelobes and Stopband for Cognitive Radar via Relaxed Alternating Projection
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Cognitive radar could adapt the spectrum of waveforms in response to information regarding the changing environment, so as to avoid narrowband interference or electronic jamming. Besides stopband constraints, low range sidelobes and unimodular property are also desired. In this paper, we propose a Spectral Approximation Relaxed Alternating Projection (SARAP) method, to synthesize unimodular waveform with […]
Awakening Blood Pressure Rise in a Patient with Spinal Cord Injury.
*Awakening Blood Pressure Rise in a Patient with Spinal Cord Injury.* Am J Case Rep. 2016;17:177-181 Authors: Ishikawa J, Watanabe S, Harada K Abstract BACKGROUND The pathophysiological mechanism causing awakening blood pressure (BP) rise is not clear. CASE REPORT We report the case of a 66-year-old man with a history of spinal cord injury, and who had remarkable awakening BP rise in ambulatory BP monitoring. The patient also had orthostatic hypotension and post-prandial hypotension associated with an increased insulin level. This case suggests that awakening BP rise can occur wi...περισσότερα »
Implanting straight into cochlea risks the facial nerve: a Cartesian coordinate study.
*Implanting straight into cochlea risks the facial nerve: a Cartesian coordinate study.* Surg Radiol Anat. 2016 Mar 19; Authors: Deshpande AS, Wendell Todd N Abstract PURPOSE: To describe the straight-into-cochlea line that affords the best access for an electrode array to enter via the round window, and how this line relates to the facial nerve, the incus, and mastoid size. The straight-into-cochlea line is important to minimize the cochlear trauma and maximize the likelihood of placement into the scala tympani. METHODS: High-resolution CT scans were obtained for ten craniums wit... περισσότερα »
Relapsing polychondritis and lymphocytic meningitis with varied neurological symptoms.
Relapsing polychondritis and lymphocytic meningitis with varied neurological symptoms. Rev Bras Reumatol. 2016 Feb 5; Authors: Ducci RD, Germiniani FM, Czecko LE, Paiva ES, Teive HA Abstract BACKGROUND: Relapsing polychondritis is a rare multisystem disease characterized by bilateral auricular and nasal chondritis and vestibular involvement, additionally affecting various other organs/systems. However, Central Nervous System involvement… Continue reading Relapsing polychondritis and lymphocytic meningitis with varied neurological symptoms.
New insights on PI3K/AKT pathway alterations and clinical outcomes in breast cancer.
New insights on PI3K/AKT pathway alterations and clinical outcomes in breast cancer. Cancer Treat Rev. 2016 Mar 9;45:87-96 Authors: Yang SX, Polley E, Lipkowitz S Abstract PI3K/AKT signaling pathway plays an important role in tumorigenesis and regulates critical cellular functions including survival, proliferation and metabolism. PIK3CA mutations and AKT activation by phosphorylation (pAKT) are often… Continue reading New insights on PI3K/AKT pathway alterations and clinical outcomes in breast cancer.
Personalized therapy for hepatocellular carcinoma: Where are we now?
Personalized therapy for hepatocellular carcinoma: Where are we now? Cancer Treat Rev. 2016 Mar 2;45:77-86 Authors: Chan SL, Wong AM, Lee K, Wong N, Chan AK Abstract Following the approval of sorafenib, a large number of molecular targeted agents have been tested clinically for advanced hepatocellular carcinoma (HCC), but all have failed to demonstrate significant… Continue reading Personalized therapy for hepatocellular carcinoma: Where are we now?
Implanting straight into cochlea risks the facial nerve: a Cartesian coordinate study.
Implanting straight into cochlea risks the facial nerve: a Cartesian coordinate study. Surg Radiol Anat. 2016 Mar 19; Authors: Deshpande AS, Wendell Todd N Abstract PURPOSE: To describe the straight-into-cochlea line that affords the best access for an electrode array to enter via the round window, and how this line relates to the facial nerve,… Continue reading Implanting straight into cochlea risks the facial nerve: a Cartesian coordinate study.
Toxins, Vol. 8, Pages 84: Gastrointestinal Degradation of Fumonisin B1 by Carboxylesterase FumD Prevents Fumonisin Induced Alteration of Sphingolipid Metabolism in Turkey and Swine
The mycotoxin fumonisin B1 (FB1) is a frequent contaminant of feed and causes various adverse health effects in domestic animals. Hence, effective strategies are needed to prevent the impact of fumonisins on livestock productivity. Here we evaluated the capability of the fumonisin carboxylesterase FumD to degrade FB1 to its less toxic metabolite hydrolyzed FB1 (HFB1)… Continue reading Toxins, Vol. 8, Pages 84: Gastrointestinal Degradation of Fumonisin B1 by Carboxylesterase FumD Prevents Fumonisin Induced Alteration of Sphingolipid Metabolism in Turkey and Swine
Toxins, Vol. 8, Pages 84: Gastrointestinal Degradation of Fumonisin B1 by Carboxylesterase FumD Prevents Fumonisin Induced Alteration of Sphingolipid Metabolism in Turkey and Swine
The mycotoxin fumonisin B1 (FB1) is a frequent contaminant of feed and causes various adverse health effects in domestic animals. Hence, effective strategies are needed to prevent the impact of fumonisins on livestock productivity. Here we evaluated the capability of the fumonisin carboxylesterase FumD to degrade FB1 to its less toxic metabolite hydrolyzed FB1 (HFB1)… Continue reading Toxins, Vol. 8, Pages 84: Gastrointestinal Degradation of Fumonisin B1 by Carboxylesterase FumD Prevents Fumonisin Induced Alteration of Sphingolipid Metabolism in Turkey and Swine
Rewarded visual items capture attention only in heterogeneous contexts
Abstract Reward is known to affect visual search performance. Rewarding targets can increase search performance, whereas rewarding distractors can decrease search performance. We used subcomponents of the N2pc in the event-related EEG, the NT (target negativity) and ND/PD (distractor negativity/positivity), in a visual search task to disentangle target and distractor processing related to reward. The visual search task comprised homogeneous and heterogeneous contexts in which a target and a colored distractor were embedded. After each correct trial, participants were given a monet...περισσότερα »
One-year developmental stability and covariance among oddball, novelty, go/no-go, and flanker event-related potentials in adolescence: A monozygotic twin study
Abstract ERP measures may index genetic risk for psychopathology before disorder onset in adolescence, but little is known about their developmental rank-order stability during this period of significant brain maturation. We studied ERP stability in 48 pairs of identical twins (age 14–16 years) tested 1 year apart. Trial-averaged voltage waveforms were extracted from electroencephalographic recordings from oddball/novelty, go/no-go, and flanker tasks, and 16 amplitude measures were examined. Members of twin pairs were highly similar, whether based on ERP amplitude measures (intrac... περισσότερα »
Validation of a reading assessment for persons with homonymous hemianopia and quadrantanopia
Archives of Physical Medicine and Rehabilitation from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1o19sTC
Impact of the US Food and Drug Administration's Safety-Related Announcements on the Use of Bisphosphonates after Hip Fracture
Journal of Bone and Mineral Research from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1pWwpsE
Outcomes following external iliac and femoral vascular injuries
Annals of Vascular Surgery from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1o19qLq
End-tidal carbon dioxide monitoring and load band device for mechanical cardio-pulmonary resuscitation: Never trust the numbers, believe at the curves
Resuscitation from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1pWwpsw
Prevention and control of carbapenemase-producing organisms at a regional burns centre
Journal of Hospital Infection from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1o19qLk
Aspects of posttraumatic stress disorder in long-term testicular cancer survivors: cross-sectional and longitudinal findings
Journal of Cancer Survivorship from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1pWwpcc
Greater fall risk in elderly women than in men is associated with increased gait variability during multitasking
Journal of the American Medical Directors Association from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1o19qv0
