Endocrinology
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds A case series on the use of circumferential radiofrequency ablation for early esophageal squamous neoplasias in patients with esophageal varices Today, 28 Ιουνίου 2016, 6 hours ago | Wen-Lun Wang, I-Wei Chang, Chien-Chuan Chen, Chi-Yang Chang, Lein-Ray Mo, Jaw-Town Lin, Hsiu-Po Wang, Ching-Tai ... περισσότερα »
OtoRhinoLaryngology
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds Gain The Upperhand-More Political Influence For ASBA Members Today, 28 Ιουνίου 2016, 1 hour ago | Αλέξανδρος Σφακιανάκης There is no doubt that the Presidential election has been on the forefront of political news this year. The latest on the subject mentioned by multiple media outlets surrou... περισσότερα »
Characteristics of temporomandibular joint structures after mandibular condyle fractures revealed by magnetic resonance imaging
Characteristics of temporomandibular joint structures after mandibular condyle fractures revealed by magnetic resonance imaging: Abstract Background This study aimed to evaluate the structural changes of temporomandibular joint immediately after condylar fractures with magnetic resonance imaging (MRI). Method We evaluated 34 subjects of condylar fractures with MRI. The position, shape, and signal intensity of the condyle, disc, and retrodiscal tissue were analyzed with MR images. Results Immediately after trauma, the disc was displaced with the fractured segment in almost a... περισσότερα »
Clostridial Collagenase Ointment
Treating Pressure Ulcers with Clostridial Collagenase Ointment: Results From the US Wound Registry: ABSTRACT We assessed the clinical effectiveness of clostridial collagenase ointment as an adjunct to selective debridement compared with selective debridement alone for the management of stage IV pressure ulcers in the hospital outpatient department setting. Outcomes data were derived from retrospective de-identified electronic medical records from 2007–2013 using the United States Wound Registry. A propensity score method was used to adjust for selection bias and to test for treatme... περισσότερα »
Fibrin-based stem cell containing scaffold improves the dynamics of burn wound healing
Fibrin-based stem cell containing scaffold improves the dynamics of burn wound healing: [image: cover.gif?v=1&s=d51423ca534c1ade92297318] ABSTRACT For severe burn injuries, successful medical intervention is accomplished by rapidly and safely providing physical barriers that can cover damaged skin tissues, thereby preventing critical danger of extensive bleeding and infection. Despite availability of a large assortment of wound coverage options, the etiology of wound healing is rather complex leading to significant defects in skin repair. The use of cell-mediated treatment app... περισσότερα »
Modified alar base cinch suture fixation at the bilateral lower border of the piriform rim after a maxillary Le Fort I osteotomy
Modified alar base cinch suture fixation at the bilateral lower border of the piriform rim after a maxillary Le Fort I osteotomy: Classic cinch suture narrowing of the nasal alar base by medially suturing the bilateral nasolabial soft tissue with one long suture has a limited effect. The modified cinch method described in the present study anchors non-absorbable sutures to the bilateral lower border of the piriform rim and provides optimal direction, position, and stability. The sutures can be shortened and the strength kept stable while the surgical wounds heal. Separate bilateral ... περισσότερα »
The Obwegeser and Dal Pont bilateral sagittal split osteotomy
Three-dimensional fracture pattern analysis of the Obwegeser and Dal Pont bilateral sagittal split osteotomy: The Obwegeser and Dal Pont modification of the bilateral sagittal split osteotomy (BSSO) is a well-established procedure in orthognathic surgery. The purpose of this retrospective study was to analyze the actual fracture patterns achieved with BSSO by Obwegeser and Dal Pont modification using postoperative cone beam computed tomography (CBCT) datasets from 100 patients. A total of 200 split osteotomies were assessed, which could be categorized into nine different split patter... περισσότερα »
Maternal biomarkers of methylation status and non-syndromic orofacial cleft risk
: a meta-analysis: Animal models have shown evidence of the role of maternal methyl donor status and its metabolism (one-carbon metabolism) in normal embryonic maxillofacial development. Nevertheless, studies in humans have shown conflicting results for the association of maternal methylation status biomarkers in the aetiology of the main craniofacial birth defects: non-syndromic orofacial clefts (NSOFCs). The aim of this study was to perform a meta-analysis assessing the relationship between maternal levels of methylation status biomarkers (plasma and erythrocyte folates and plasma ... περισσότερα »
Guided bone regeneration using individualized ceramic sheets
Guided bone regeneration using individualized ceramic sheets: Guided bone regeneration (GBR) describes the use of membranes to regenerate bony defects. A membrane for GBR needs to be biocompatible, cell-occlusive, non-toxic, and mouldable, and possess space-maintaining properties including stability. The purpose of this pilot study was to describe a new method of GBR using individualized ceramic sheets to perfect bone regeneration prior to implant placement; bone regeneration was assessed using traditional histology and three-dimensional (3D) volumetric changes in the bone and soft ... περισσότερα »
Penetrating Craniomaxillofacial Injury Caused by a Pneumatic Nail Gun
Penetrating Craniomaxillofacial Injury Caused by a Pneumatic Nail Gun: Cranial Maxillofac Trauma Reconstruction DOI: 10.1055/s-0036-1584405 Craniomaxillofacial injuries can be complex, requiring a multidisciplinary approach. The primary survey is always the first step in trauma management prior to proceeding with further evaluation and treatment. A 26-year-old man presented with a penetrating nail gun injury through the oral and nasal cavities. He did not present in extremis but required elective endotracheal intubation for intraoperative assessment and treatment. Airway management ... περισσότερα »
Sleep Medicine
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds Today, 28 Ιουνίου 2016, 8:58:42 πμ Gain The Upperhand-More Political Influence For ASBA Members Today, 28 Ιουνίου 2016, 3 hours ago | Alan Hickey There is no doubt that the Presidential election has been on the forefront of political news this year. The latest on the subject mentioned by... περισσότερα »
Diagnostic Value of 18F-Choline PET/CT in Patients With a Thyroid Nodule With an Indeterminate Cytology
Pilot Study: *Condition*: Thyroid Gland *Intervention*: Device: Radiation : PET-CT with F18-choline examination *Sponsors*: Centre Francois Baclesse; Canceropôle Nord Ouest The purpose of the study is to investigate the contribution of PET-CT with F18-choline in the diagnosis of thyroid nodule with indeterminate cytology in order to guide the best indication of surgical resection. Condition Intervention Thyroid Gland Device: Radiation : PET-CT with F18-choline examination Study Type: Interventional Study Design: Intervention Model: Single Group Assignment Masking: Open L... περισσότερα »
Proteomics of Papillary Thyroid Carcinoma
Proteomics of Papillary Thyroid Carcinoma: *Condition*: Papillary Thyroid Carcinoma *Intervention*: *Sponsor*: The Affiliated Hospital of Inner Mongolia Medical University Thyroid carcinoma is the common endocrine system malignant neoplasm. At present it has become the malignant neoplasm of fastest growing incidence rate. More than 85% thyroid carcinoma is papillary thyroid carcinoma. Cervical lymph node metastasis is common in papillary thyroid carcinoma patients. This study aim to reveal protein expression differences between papillary thyroid carcinoma with cervical lymp... περισσότερα »
Uses of Various Grafting Techniques in External Approach Rhinoplasty
An Overview: Abstract The surgeons performing rhinoplasty found Graft selection the greatest challenge. To avoid an immune response the preferred choice thus far for nasal reconstruction would be autograft compared to allograft due to its lower rate of rejection. We have evaluated 30 patients who underwent open rhinoplasty and We used conchal and septal cartilaginous grafts in various forms by the open approach to correct various nasal deformities compared our experience regarding the operative technique, graft availability, indications, and limitations. No bony graft material or ... περισσότερα »
The congenital and acquired deformities of the craniovertebral junction (CVJ), such as basilar invagination, basilar impression, or platybasia
Basilar Invagination, Basilar Impression, and Platybasia: Clinical and Imaging Aspects: Abstract The congenital and acquired deformities of the craniovertebral junction (CVJ), such as basilar invagination, basilar impression, or platybasia, can present in the form of slowly progressive or acute neurologic deterioration. In many cases, an insidious headache is the only symptom and can be a diagnostic challenge for the neurologist. Proper imaging studies as well as recognizing often associated neurologic or systemic conditions are required for early diagnosis and effective therapy. I... περισσότερα »
Chronic Rhinosinusitis Patients Show Accumulation of Genetic Variants in PARS2
Chronic Rhinosinusitis Patients Show Accumulation of Genetic Variants in PARS2: by Viktor Henmyr, Christina Lind-Halldén, Christer Halldén, Torbjörn Säll, Daniel Carlberg, Claus Bachert, Lars-Olaf Cardell Genetic studies of chronic rhinosinusitis (CRS) have identified a total of 53 CRS-associated SNPs that were subsequently evaluated for their reproducibility in a recent study. The rs2873551 SNP in linkage disequilibrium with *PARS2* showed the strongest association signal. The present study aims to comprehensively screen for rare variants in *PARS2* and evaluate for accumulation o... περισσότερα »
Is markerless acquisition technique adequate for speech production?
Is markerless acquisition technique adequate for speech production?: In this study, the precision of markerless acquisition techniques have been assessed when used to acquire articulatory data for speech production studies. Two different markerless systems have been evaluated and compared to a marker-based one. The main finding is that both markerless systems provide a reasonable result during normal speech and the quality is uneven during fast articulated speech. The quality of the data is dependent on the temporal resolution of the markerless system. http://ift.tt/28YP6Un OtoRhin... περισσότερα »
Integration of partial information for spoken and written sentence recognition by older listeners
Integration of partial information for spoken and written sentence recognition by older listeners: Older adults have difficulty understanding speech in challenging listening environments. Combining multisensory signals may facilitate speech recognition. This study measured recognition of interrupted spoken and written sentences by older adults for different preserved stimulus proportions. Unimodal performance was first examined when only interrupted text or speech stimuli were presented. Multimodal performance with concurrently presented text and speech stimuli was tested with delay... περισσότερα »
Mistuning detection performance of ferrets in a go/no-go task
Mistuning detection performance of ferrets in a go/no-go task: The harmonic structure of sounds is an important grouping cue in auditory scene analysis. The ability of ferrets to detect mistuned harmonics was measured using a go/no-go task paradigm. Psychometric functions plotting sensitivity as a function of degree of mistuning were used to evaluate behavioral performance using signal detection theory. The mean (± standard error of the mean) threshold for mistuning detection was 0.8 ± 0.1 Hz, with sensitivity indices and reaction times depending on the degree of mistuning. These da... περισσότερα »
Allergy and Immunology
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds Today, 28 Ιουνίου 2016, 8:52:55 πμ Regulatory issues in immunity to liver and blood-stage malaria Today, 28 Ιουνίου 2016, 5 hours ago Natalija Van Braeckel-Budimir | Samarchith P Kurup | John T Harty Eosinophilic bioactivities in severe asthma Today, 28 Ιουνίου 2016, 6 hours ago | ... περισσότερα »
Squamous cell carcinoma (SCC) - Cancer - Melanoma
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds Dose-escalation study of tabalumab with bortezomib and dexamethasone in Japanese patients with multiple myeloma Today, 28 Ιουνίου 2016, 44 minutes ago [image: cover.gif?v=1&s=cd51c7f7da7776e178cb46d5] Abstract B-cell activating factor (BAFF) promotes the survival and adhesion of multiple mye... περισσότερα »
Contemporary management of large-volume arteriovenous malformations
a clinician’s review: AbstractArteriovenous malformations (AVMs) represent a heterogeneous group of lesions, and as such, there exist several treatment options and approaches depending on size, location, grading, and symptoms. Large-volume AVMs represent a particularly challenging subset of AVMs with controversy over the very classification with definitions based on size, volume, and Spetzler-Martin grade. With regards to treatment paradigms, the natural history of these lesions is an important foundation upon which management principles have been built. At this time, management o... περισσότερα »
Modulation of innate immunity in the tumor microenvironment
Modulation of innate immunity in the tumor microenvironment: AbstractA recent report from the Center for Disease Control identified melanoma as being among the highest causes of cancer-related mortalities in the USA. While interventions such as checkpoint blockade have made substantial impact in terms of improving response rates and overall survival, a significant number of patients fail to respond to treatment or become resistant to therapy. A better understanding of the tumor microenvironment in these patients becomes imperative for identifying immune suppressive mechanisms that ... περισσότερα »
Diffuse large B-cell lymphoma (DLBCL).SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway
SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway: [image: cover.gif?v=1&s=cd51c7f7da7776e178cb46d5] Summary Although the clinical outcomes of diffuse large B-cell lymphoma (DLBCL) have improved in the immunochemotherapy era, about one third of patients develop intractable disease. To improve clinical outcomes for these patients, it is important to identify those with poor prognosis prior to initial treatment in order to select optimal therapies. Here, we investigated the clinical and biological significance of SP... περισσότερα »
Iodine-125 brachytherapy as upfront and salvage treatment for brain metastases
Iodine-125 brachytherapy as upfront and salvage treatment for brain metastases: Abstract BackgroundOutcome and toxicity profiles of salvage stereotactic ablative radiation strategies for recurrent pre-irradiated brain metastases are poorly defined. This study compared risk–benefit profiles of upfront and salvage iodine-125 brachytherapy (SBT) for small brain metastases. As the applied SBT treatment algorithm required histologic proof of metastatic brain disease in all patients, we additionally aimed to elucidate the value of biopsy before SBT. Patients and methodsPatients with... περισσότερα »
Current Status of Biological Therapies for the Treatment of Metastatic Melanoma
Current Status of Biological Therapies for the Treatment of Metastatic Melanoma: Compared to early-stage melanoma when surgical excision is possible, metastatic disease continues to offer a much grimmer prognosis as traditional chemotherapy treatment regimens offer relatively little survival benefit. This has led to changes in treatment approaches over the preceding two decades as contemporary methods for the treatment of advanced or metastatic melanoma now involve a number of biological modalities, which include immunotherapeutic approaches, targeted therapies and epigenetic modi... περισσότερα »
The 1G/1G genotype of MMP-1 promoter -1607 may independently have a protective effect on NPC risk
Contribution of Matrix Metallopeptidase-1 Genotypes, Smoking, Alcohol Drinking and Areca Chewing to Nasopharyngeal Carcinoma Susceptibility: Background/Aim: The up-regulation of matrix metalloproteinase-1 (MMP-1) has been demonstrated to be correlated with lymph node metastasis of nasopharyngeal carcinoma (NPC); however, the genotypic role of MMP-1 is not well understand. The present study aimed to assess the contribution of MMP-1 promoter -1607 genotypes, combined with environmental carcinogens, on the predisposition to NPC tumorigenesis. Materials and Methods: The MMP-1 promoter ... περισσότερα »
Peripheral blood mononuclear cells (PBMCs) activated with immobilized monoclonal antibody against cluster of differentiation 3 (CD3) secrete cytokines in their culture supernatant (termed ACD3S)
A Cytokine Cocktail Augments the Efficacy of Adoptive NK-92 Cell Therapy Against Mouse Xenografts of Human Cancer: Background/Aim: Peripheral blood mononuclear cells (PBMCs) activated with immobilized monoclonal antibody against cluster of differentiation 3 (CD3) secrete cytokines in their culture supernatant (termed ACD3S). We examined the antitumor efficacy of ACD3S-activated NK-92 cells in vitro and in vivo. Materials and Methods: Interleukin (IL) 2-depleted NK-92 cells were reactivated with ACD3S, analyzed for their phenotype and tested for cytotoxicity, and perforin and interf... περισσότερα »
Stimulation of NK-92 cells with ACD3S may be useful in clinical cancer therapy, as an alternative method for ex vivo natural killer cell activation.
A Cytokine Cocktail Augments the Efficacy of Adoptive NK-92 Cell Therapy Against Mouse Xenografts of Human Cancer: Background/Aim: Peripheral blood mononuclear cells (PBMCs) activated with immobilized monoclonal antibody against cluster of differentiation 3 (CD3) secrete cytokines in their culture supernatant (termed ACD3S). We examined the antitumor efficacy of ACD3S-activated NK-92 cells in vitro and in vivo. Materials and Methods: Interleukin (IL) 2-depleted NK-92 cells were reactivated with ACD3S, analyzed for their phenotype and tested for cytotoxicity, and perforin and interf... περισσότερα »
Prognostic Significance of NOGO-A/B and NOGO-B Receptor Expression in Malignant Melanoma
- A Preliminary Study: Background: Neurite outgrowth inhibitor type B (NOGO-B) and its receptor (NGBR) were shown to regulate various crucial cellular processes and may be therefore potential factors influencing carcinogenesis. Materials and Methods: Expression of NOGO-A, NOGO-A/B and NGBR was studied in benign melanocytic lesions and primary tumors and metastases of malignant melanoma (MM). Results: Cytoplasmic expression of the studied antigens was detected in melanocytes and MM cells. NOGO-A/B expression was significantly lower in metastatatic MM cases compared to primary MM tu... περισσότερα »
Superselective Intra-arterial Chemotherapy for Recurrent Cancer of the Skull Base
Impact of Endoscopic Indocyanine Green Fluorescence Imaging on Superselective Intra-arterial Chemotherapy for Recurrent Cancer of the Skull Base: Background/Aim: For advanced paranasal sinus cancer, intra-arterial (I-A) chemotherapy has been applied for improving prognosis and organ preservation. While computed tomographic angiography (CTA) is useful for identifying the tumor-feeding artery, CTA cannot always detect the precise artery. The aim of this study was to assess the feasibility of endoscopic ICG (indocyanine green) fluorescence technique during I-A chemotherapy for recurr... περισσότερα »
Volumetric Modulated Arc Therapy in Oropharyngeal Carcinoma
Treatment: Outcome and Toxicity of Volumetric Modulated Arc Therapy in Oropharyngeal Carcinoma: Background/Aim: Radiotherapy is a common approach for treating squamous cell carcinoma (SCC) of the oropharynx. We aimed to analyze toxicity and outcome of patients affected by oropharyngeal SCC treated with volumetric modulated arc therapy (VMAT). Patients and Methods: Fifty-four patients presenting advanced orophayngeal carcinoma who were treated with radical radiotherapy were analyzed. All patients were treated with VMAT-RapidArc, with simultaneous integrated boost in 33 fractions for... περισσότερα »
The Expression of Thyroid Transcription Factor 1 (TTF1)
Prognostic Factors Including the Expression of Thyroid Transcription Factor 1 (TTF1) in Patients Irradiated for Limited-disease Small Cell Lung Cancer: Aim: To investigate the impact of tumor-cell expression of thyroid transcription factor 1 (TTF1) on outcomes after irradiation of limited-disease small cell lung cancer (LD-SCLC). Patients and Methods: TTF1 expression plus eight factors were evaluated in 32 patients for locoregional recurrence-free survival (LRFS), metastases-free survival (MFS) and overall survival (OS). These factors included age, gender, Karnofsky performance sco... περισσότερα »
Resveratrol Overcomes Cellular Resistance to Vemurafenib Through Dephosphorylation of AKT in BRAF-mutated Melanoma Cells
Resveratrol Overcomes Cellular Resistance to Vemurafenib Through Dephosphorylation of AKT in BRAF-mutated Melanoma Cells: Background/Aim: The serine/threonine-protein kinase B-Raf (BRAF) V600E mutant (BRAFV600E) inhibitor vemurafenib, has improved clinical outcomes for patients with BRAFV600E melanoma, but acquired cellular resistance mediated by AKT serine/threonine kinase 1 (AKT) phosphorylation limits its efficacy. We examined the effect of resveratrol on vemurafenib-resistant melanoma cells. Materials and Methods: A vemurafenib-resistant human metastatic melanoma cell line posi... περισσότερα »
Liver Injury After Invariant NKT Cell Activation by Free Alpha-galactosylceramide and Alpha-galactosylceramide-loaded Dendritic Cells
Liver Injury After Invariant NKT Cell Activation by Free Alpha-galactosylceramide and Alpha-galactosylceramide-loaded Dendritic Cells: Background/Aim: Both free alpha-galactosylceramide (αGalCer) and αGalCer-loaded dendritic cells (DCG) activate invariant natural killer T (iNKT) cells to varying degrees, with αGalCer inducing liver injury. We sought to evaluate liver injury by these two pathways. Materials and Methods: Mice were injected with αGalCer or DCG followed by analysis of serum alanine transaminase (ALT) activity levels, mortality and liver function. Results: While ALT le... περισσότερα »
Immunohistochemical Analysis of WT1 Antigen Expression in Various Solid Cancer Cells
Immunohistochemical Analysis of WT1 Antigen Expression in Various Solid Cancer Cells: For a peptide-pulsed dendritic cell (DC) vaccine to work effectively in cancer treatment, it is significant that the target protein is expressed in cancer cells. Wilms' tumor 1 (WT1) has been identified as a molecular target for immune cell therapy of cancer. We evaluated the protein expression levels of WT1 in various solid tumors, as well as mucin 1 (MUC1) or major histocompatibility complex (MHC) class l molecules. Seven hundred and thirty-eight patients whose tissue samples were examined by i... περισσότερα »
A comprehensive genome-wide analysis of melanoma Breslow thickness identifies interaction between CDC42 and SCIN genetic variants
A comprehensive genome-wide analysis of melanoma Breslow thickness identifies interaction between CDC42 and SCIN genetic variants: Abstract Breslow thickness (BT) is a major prognostic factor of cutaneous melanoma (CM), the most fatal skin cancer. The genetic component of BT has only been explored by candidate gene studies with inconsistent results. Our objective was to uncover the genetic factors underlying BT using an hypothesis-free genome-wide approach. Our analysis strategy integrated a genome-wide association study (GWAS) of single nucleotide polymorphisms (SNPs) for BT follo... περισσότερα »
The diagnosis and treatment in radioiodine-refractory differentiated thyroid carcinoma.miRNA-106a, directly targeting RARB, associates with the viability, apoptosis, differentiation and the iodine uptake function of thyroid cancer cell lines by regulating MAPK signaling pathway
miRNA-106a directly targeting RARB associates with the expression of Na+/I− symporter in thyroid cancer by regulating MAPK signaling pathway: Abstract Background Serum miRNAs profiles between papillary thyroid carcinoma (PTC) patients with non-131I and 131I-avid lung metastases are differentially expressed. These miRNAs have to be further validated and the role of these miRNAs in the molecular function level of thyroid cancer cell lines has not been investigated. Methods Expression levels of six identified miRNAs were assessed via quantitative real-time PCR (qRT-PCR) in... περισσότερα »
Grading von Tumoren der Kopf‑Hals‑Region
Grading von Tumoren der Kopf‑Hals‑Region: ZusammenfassungKopf-Hals-Tumoren bilden eine Gruppe sehr heterogener benigner und maligner Neoplasien unter Einschluss zahlreicher Entitäten. Die zahlenmäßig häufigste und aus onkologischer Sicht bedeutsamste Tumorfamilie dieser Lokalisation bilden die Plattenepithelkarzinome des Larynx, Pharynx und der Mundhöhle. Die Graduierung dieser Tumoren erfolgt nach histomorphologischen Parametern unter Berücksichtigung architektonischer und zytologischer Kriterien. Allerdings ist die prognostische und therapeutische Bedeutung aktueller Graduierung... περισσότερα »
Feinnadelaspiration (FNA) der Schilddrüse
Feinnadelaspiration (FNA) der Schilddrüse: Zusammenfassung HintergrundDie diagnostischen Schwierigkeiten der Schilddrüsenzytologie werden in der Literatur häufig diskutiert, aber nur selten wird den Ursachen und der Relevanz von sich widersprechenden zytologischen und histologischen Befunden im Einzelnen nachgegangen. FragestellungWas sind die Ursachen von Diskrepanzen und wie sind sie zu werten? Material und MethodeDie vergleichende Untersuchung stützt sich auf 297 nach vorausgehender Feinnadelaspiration (FNA) operierte Patienten. Ausgewertet wurden die zytologischen und h... περισσότερα »
The right-sided aortic arch with unusual course of bilateral recurrent laryngeal nerves
a report of rare variations: AbstractWe describe a rare case of the right-sided aortic arch, the unusual origin of the main arterial vessels and the unusual courses of bilateral recurrent laryngeal nerves in a Japanese cadaver. Chiefly, the right-sided aortic arch turned to the left side from the dorsal part of the trachea and esophagus, and Kommerell’s diverticulum was found at the end of the arch. The right common carotid artery arose from the end part of the ascending aorta, but the left common carotid artery arose from the proximal portion of the ascending aorta. The right sub... περισσότερα »
Impact of Afirma gene expression classifier on cytopathology diagnosis and rate of thyroidectomy
Impact of Afirma gene expression classifier on cytopathology diagnosis and rate of thyroidectomy: BACKGROUND The Afirma gene expression classifier (GEC) assesses malignancy risk in patients with indeterminate thyroid nodules. Afirma putatively reduces costs by classifying certain nodules as benign and thereby avoiding unnecessary surgery. Prior studies have evaluated its impact exclusively on GEC-tested nodules. The objective of the current study was to analyze the effect of Afirma on 1) cytopathology diagnosis, 2) the rate of surgery, and 3) the rate of malignancy on all indetermi... περισσότερα »
Human papillomavirus infection and p16 expression in the immunocompetent patients with extragenital/extraungual Bowen’s disease
Human papillomavirus infection and p16 expression in the immunocompetent patients with extragenital/extraungual Bowen’s disease: Abstract Background The role of human papillomaviruses (HPV) in the development of squamous cell carcinoma (SCC) has been established for anogenital lesions but still remains controversial for carcinomas in other sites. The aim of this study was to determine the α-HPV and β-HPV prevalence and their association with p16 expression, sun exposure, and clinicopathological findings in patients with Bowen’s disease (BD). Methods One hundred sixty nin... περισσότερα »
Paediatric Ewing-like sarcoma arising from the cranium – a unique diagnostic challenge
Paediatric Ewing-like sarcoma arising from the cranium – a unique diagnostic challenge: Abstract Background Paediatric undifferentiated soft tissue sarcomas are a group of tumours that have remained diagnostically challenging. Recently, a subgroup of undifferentiated soft tissue sarcomas with a round to plump spindle cell morphology, expressing the CIC-DUX4 fusion transcript as a result of the t(4;19) or t(10;19) translocation have been identified. Case presentation We describe the first case of a CIC-DUX4 positive EWSR-1 negative undifferentiated small blue round cell ... περισσότερα »
Frequency of BRAF V600E mutations in 969 central nervous system neoplasms
Frequency of BRAF V600E mutations in 969 central nervous system neoplasms: Abstract Background Treatment options for oncological diseases have been enhanced by the advent of targeted therapies. The point mutation of the BRAF gene at codon 600 (BRAF V600E) is found in several tumor entities and can be approached with selective inhibitory antibodies. The BRAF inhibitor vemurafenib has demonstrated clinical efficacy in patients with BRAF V600E-mutant melanoma brain metastases and in other cancer diseases. Therefore the BRAF V600E mutation is a highly interesting oncological ta... περισσότερα »
An automated real-time method for the detection of patients at risk for malignant hyperthermia
An automated real-time method for the detection of patients at risk for malignant hyperthermia: Summary Background Malignant hyperthermia (MH) is a rare anesthetic pharmacogenetic disorder that can be difficult to detect in its earliest phases. Prompt treatment is known to improve outcomes. The modern anesthesia information management systems (AIMS) collect enormous amounts of data. However, data lack context and are not able to provide real-time guidance. Utilizing our AIMS, we developed the capacity to incorporate decision support. Aims We describe the creation and evaluation of a... περισσότερα »
Paediatric Ewing-like sarcoma arising from the cranium – a unique diagnostic challenge
Paediatric Ewing-like sarcoma arising from the cranium – a unique diagnostic challenge: Abstract Background Paediatric undifferentiated soft tissue sarcomas are a group of tumours that have remained diagnostically challenging. Recently, a subgroup of undifferentiated soft tissue sarcomas with a round to plump spindle cell morphology, expressing the CIC-DUX4 fusion transcript as a result of the… Continue reading Paediatric Ewing-like sarcoma arising from the cranium – a unique diagnostic challenge
Catalysts, Vol. 6, Pages 95: The Performance of Electron-Mediator Modified Activated Carbon as Anode for Direct Glucose Alkaline Fuel Cell
Six different electron mediators were immobilized on the activated carbon (AC) anode and their effects on performance of a direct glucose alkaline fuel cell were explored. 2-hydroxy-1, 4-naphthoquinone (NQ), methyl viologen (MV), neutral red (NR), methylene blue (MB), 1, 5-dichloroanthraquinone (DA) and anthraquinone (AQ) were doped in activated carbon (AC), respectively, and pressed on nickel… Continue reading Catalysts, Vol. 6, Pages 95: The Performance of Electron-Mediator Modified Activated Carbon as Anode for Direct Glucose Alkaline Fuel Cell
Frequency of BRAF V600E mutations in 969 central nervous system neoplasms
Frequency of BRAF V600E mutations in 969 central nervous system neoplasms: Abstract Background Treatment options for oncological diseases have been enhanced by the advent of targeted therapies. The point mutation of the BRAF gene at codon 600 (BRAF V600E) is found in several tumor entities and can be approached with selective inhibitory antibodies. The BRAF… Continue reading Frequency of BRAF V600E mutations in 969 central nervous system neoplasms
An automated real-time method for the detection of patients at risk for malignant hyperthermia
An automated real-time method for the detection of patients at risk for malignant hyperthermia: Summary Background Malignant hyperthermia (MH) is a rare anesthetic pharmacogenetic disorder that can be difficult to detect in its earliest phases. Prompt treatment is known to improve outcomes. The modern anesthesia information management systems (AIMS) collect enormous amounts of data. However,… Continue reading An automated real-time method for the detection of patients at risk for malignant hyperthermia
Characteristics of temporomandibular joint structures after mandibular condyle fractures revealed by magnetic resonance imaging
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Characteristics of temporomandibular joint structures after mandibular condyle fractures revealed by magnetic resonance imaging: Abstract Background This study aimed to evaluate the structural changes of temporomandibular joint immediately after condylar fractures with magnetic resonance imaging (MRI). Method We evaluated 34 subjects of condylar fractures with MRI. The position, shape, and signal intensity of the condyle, […]
Clostridial Collagenase Ointment
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Treating Pressure Ulcers with Clostridial Collagenase Ointment: Results From the US Wound Registry: ABSTRACT We assessed the clinical effectiveness of clostridial collagenase ointment as an adjunct to selective debridement compared with selective debridement alone for the management of stage IV pressure ulcers in the hospital outpatient department setting. Outcomes data were derived from retrospective de-identified […]
Fibrin-based stem cell containing scaffold improves the dynamics of burn wound healing
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Fibrin-based stem cell containing scaffold improves the dynamics of burn wound healing: ABSTRACT For severe burn injuries, successful medical intervention is accomplished by rapidly and safely providing physical barriers that can cover damaged skin tissues, thereby preventing critical danger of extensive bleeding and infection. Despite availability of a large assortment of wound coverage options, the […]
Modified alar base cinch suture fixation at the bilateral lower border of the piriform rim after a maxillary Le Fort I osteotomy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Modified alar base cinch suture fixation at the bilateral lower border of the piriform rim after a maxillary Le Fort I osteotomy: Classic cinch suture narrowing of the nasal alar base by medially suturing the bilateral nasolabial soft tissue with one long suture has a limited effect. The modified cinch method described in the present […]
The Obwegeser and Dal Pont bilateral sagittal split osteotomy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Three-dimensional fracture pattern analysis of the Obwegeser and Dal Pont bilateral sagittal split osteotomy: The Obwegeser and Dal Pont modification of the bilateral sagittal split osteotomy (BSSO) is a well-established procedure in orthognathic surgery. The purpose of this retrospective study was to analyze the actual fracture patterns achieved with BSSO by Obwegeser and Dal Pont […]
Maternal biomarkers of methylation status and non-syndromic orofacial cleft risk
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
: a meta-analysis: Animal models have shown evidence of the role of maternal methyl donor status and its metabolism (one-carbon metabolism) in normal embryonic maxillofacial development. Nevertheless, studies in humans have shown conflicting results for the association of maternal methylation status biomarkers in the aetiology of the main craniofacial birth defects: non-syndromic orofacial clefts (NSOFCs). […]
Guided bone regeneration using individualized ceramic sheets
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Guided bone regeneration using individualized ceramic sheets: Guided bone regeneration (GBR) describes the use of membranes to regenerate bony defects. A membrane for GBR needs to be biocompatible, cell-occlusive, non-toxic, and mouldable, and possess space-maintaining properties including stability. The purpose of this pilot study was to describe a new method of GBR using individualized ceramic […]
Penetrating Craniomaxillofacial Injury Caused by a Pneumatic Nail Gun
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Penetrating Craniomaxillofacial Injury Caused by a Pneumatic Nail Gun: Cranial Maxillofac Trauma Reconstruction DOI: 10.1055/s-0036-1584405 Craniomaxillofacial injuries can be complex, requiring a multidisciplinary approach. The primary survey is always the first step in trauma management prior to proceeding with further evaluation and treatment. A 26-year-old man presented with a penetrating nail gun injury through the […]
Sleep Medicine
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You’ve successfully subscribed to this feed! Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds Today, 28 Ιουνίου 2016, 8:58:42 πμ Gain The Upperhand-More Political […]
Diagnostic Value of 18F-Choline PET/CT in Patients With a Thyroid Nodule With an Indeterminate Cytology
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Pilot Study: Condition: Thyroid Gland Intervention: Device: Radiation : PET-CT with F18-choline examination Sponsors: Centre Francois Baclesse; Canceropôle Nord Ouest The purpose of the study is to investigate the contribution of PET-CT with F18-choline in the diagnosis of thyroid nodule with indeterminate cytology in order to guide the best indication of surgical resection. Condition Intervention […]
Water, Vol. 8, Pages 269: A Novel Approach for Estimating the Recurrence Intervals of Channel-Forming Discharges
Channel-forming discharges typically are associated with recurrence intervals less than five years and usually less than two years. However, the actual frequency of occurrence of these discharges is often several times more frequent than the statistical expectation. This result was confirmed by using the Log-Pearson Type 3 statistical method to analyze measured annual series of instantaneous peaks and peak daily means for 150 catchments in six states in the North Central Region of the United States. Discharge records ranged from 39 to 102 years and catchment sizes ranged from 29 t... περισσότερα »
Catalysts, Vol. 6, Pages 95: The Performance of Electron-Mediator Modified Activated Carbon as Anode for Direct Glucose Alkaline Fuel Cell
Six different electron mediators were immobilized on the activated carbon (AC) anode and their effects on performance of a direct glucose alkaline fuel cell were explored. 2-hydroxy-1, 4-naphthoquinone (NQ), methyl viologen (MV), neutral red (NR), methylene blue (MB), 1, 5-dichloroanthraquinone (DA) and anthraquinone (AQ) were doped in activated carbon (AC), respectively, and pressed on nickel foam to fabricate the anodes. NQ shows comparable performance with MV, but with much lower cost and environmental impact. With NQ-AC anode, the fuel cell attained a peak power density of 16.... περισσότερα »
OtoRhinoLaryngology
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds Gain The Upperhand-More Political Influence For ASBA Members Today, 28 Ιουνίου 2016, 1 hour ago | Αλέξανδρος Σφακιανάκης There is no doubt that the Presidential election has been on the forefront of political news this year. The latest on the subject mentioned by multiple media outlets surrou... περισσότερα »
Acta Biomaterialia
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Orthodontics
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Annales de Chirurgie Plastique Esthétique
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Rejuvenation Research
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British Journal of Oral and Maxillofacial Surgery
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International Endodontic Journal
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Clinical Periodontology
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Endodontics
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Genetic Resistance Determinants for Cefixime and Molecular Analysis of Gonococci Isolated in Italy
Microbial Drug Resistance , Vol. 0, No. 0. from Mary Ann Liebert, Inc. publishers via xlomafota13 on Inoreader http://ift.tt/28ZgMwo via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2902qcB via IFTTT
Esthetic and Restorative Dentistry
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Dose-escalation study of tabalumab with bortezomib and dexamethasone in Japanese patients with multiple myeloma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Abstract B-cell activating factor (BAFF) promotes the survival and adhesion of multiple myeloma (MM) cells. Tabalumab (LY2127399) is an anti-BAFF monoclonal antibody. This phase 1, multicenter, open-label, nonrandomized, dose-escalation study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of tabalumab in combination with bortezomib and dexamethasone in Japanese patients with relapsed or refractory MM (RRMM). […]
Pancreatic neuroendocrine tumors (pancreatic NETs)
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Pancreatic neuroendocrine tumors (pancreatic NETs): a type of tumor that arises from hormone-producing cells in the pancreas. Pancreatic NETs may be either benign or malignant and may produce hormones (termed a «functional» pancreatic NET) or not produce hormones (a «nonfunctional» pancreatic NET). Often, the tumor itself does not produce signs or symptoms, although the hormones […]
L-DOPA-induced hyperhomocysteinemia in Parkinson’s disease: Elephant in the room
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Publication date: September 2016 Source:Biochimica et Biophysica Acta (BBA) – General Subjects, Volume 1860, Issue 9 Author(s): Rajib Paul, Anupom Borah BackgroundDopamine replacement therapy by its precursor, L-3.4-dihydroxyphenylalanine (L-DOPA), has been the treatment of choice for Parkinson’s disease. However, the possible contributory effect of L-DOPA therapy on the progression of Parkinson’s disease mediated by the […]
Smoothened-independent activation of hedgehog signaling by rearranged during transfection promotes neuroblastoma cell proliferation and tumor growth
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Publication date: September 2016 Source:Biochimica et Biophysica Acta (BBA) – General Subjects, Volume 1860, Issue 9 Author(s): Hongfeng Ruan, Huan Luo, Jirong Wang, Xing Ji, Zhongmiao Zhang, Junsong Wu, Xianning Zhang, Ximei Wu BackgroundRearranged during transfection (RET) proto-oncogene encodes a receptor tyrosine kinase for glial cell line-derived neurotrophic factor (GDNF) signaling, and high RET expression […]
PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Publication date: September 2016 Source:Biochimica et Biophysica Acta (BBA) – General Subjects, Volume 1860, Issue 9 Author(s): Natalia Alonso, Antonela Diaz Nebreda, Federico Monczor, J. Silvio Gutkind, Carlos Davio, Natalia Fernandez, Carina Shayo BackgroundHistamine, through histamine H2 receptor (H2R), modulates different biological processes, involving the modulation of PI3K/AKT/mTOR and RAS/RAF/MEK/ERK pathways. Many evidences have demonstrated […]
Reproducible preparation of spheroids of pancreatic hormone positive cells from human iPS cells: An in vitro study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Publication date: September 2016 Source:Biochimica et Biophysica Acta (BBA) – General Subjects, Volume 1860, Issue 9 Author(s): Shuhei Konagaya, Hiroo Iwata BackgroundTransplantation of islets of Langerhans is regarded as a promising therapy for type 1 diabetes. A large number of β-cells are required for the treatment of human type 1 diabetes. Pluripotent stem cells, such […]
FGF21 represses cerebrovascular aging via improving mitochondrial biogenesis and inhibiting p53 signaling pathway in an AMPK-dependent manner
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Publication date: Available online 27 June 2016 Source:Experimental Cell Research Author(s): Xiao-Mei Wang, Hang Xiao, Ling-Lin Liu, Dang Cheng, Xue-Jun Li, Liang-Yi Si Cerebrovascular aging has a high relationship with stroke and neurodegenerative disease. In the present study, we evaluated the influence of fibroblast growth factor 21 (FGF21) on angiotensin (Ang II)-mediated cerebrovascular aging in […]
The big bang blip: Solving the mystery of why matter exists
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Matter and antimatter should have wiped each other out at the universe’s birth. The upgraded Large Hadron Collider aims to find why matter alone survived from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VfnEFn via IFTTT
An Integrated Approach for RNA-seq Data Normalization
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Background: DNA copy number alteration is common in many cancers. Studies have shown that insertion or deletion of DNA sequences can directly alter gene expression, and significant correlation exists between DNA copy number and gene expression. Data normalization is a critical step in the analysis of gene expression generated by RNA-seq technology. Successful normalization reduces/removes […]
The big bang blip: Solving the mystery of why matter exists
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Matter and antimatter should have wiped each other out at the universe’s birth. The upgraded Large Hadron Collider aims to find why matter alone survived from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VfnEFn via IFTTT
Uses of Various Grafting Techniques in External Approach Rhinoplasty
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
An Overview: Abstract The surgeons performing rhinoplasty found Graft selection the greatest challenge. To avoid an immune response the preferred choice thus far for nasal reconstruction would be autograft compared to allograft due to its lower rate of rejection. We have evaluated 30 patients who underwent open rhinoplasty and We used conchal and septal cartilaginous […]
The congenital and acquired deformities of the craniovertebral junction (CVJ), such as basilar invagination, basilar impression, or platybasia
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
Basilar Invagination, Basilar Impression, and Platybasia: Clinical and Imaging Aspects: Abstract The congenital and acquired deformities of the craniovertebral junction (CVJ), such as basilar invagination, basilar impression, or platybasia, can present in the form of slowly progressive or acute neurologic deterioration. In many cases, an insidious headache is the only symptom and can be a […]
Chronic Rhinosinusitis Patients Show Accumulation of Genetic Variants in PARS2
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
Chronic Rhinosinusitis Patients Show Accumulation of Genetic Variants in PARS2: by Viktor Henmyr, Christina Lind-Halldén, Christer Halldén, Torbjörn Säll, Daniel Carlberg, Claus Bachert, Lars-Olaf Cardell Genetic studies of chronic rhinosinusitis (CRS) have identified a total of 53 CRS-associated SNPs that were subsequently evaluated for their reproducibility in a recent study. The rs2873551 SNP in linkage […]
Is markerless acquisition technique adequate for speech production?
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
Is markerless acquisition technique adequate for speech production?: In this study, the precision of markerless acquisition techniques have been assessed when used to acquire articulatory data for speech production studies. Two different markerless systems have been evaluated and compared to a marker-based one. The main finding is that both markerless systems provide a reasonable result […]
Integration of partial information for spoken and written sentence recognition by older listeners
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
Integration of partial information for spoken and written sentence recognition by older listeners: Older adults have difficulty understanding speech in challenging listening environments. Combining multisensory signals may facilitate speech recognition. This study measured recognition of interrupted spoken and written sentences by older adults for different preserved stimulus proportions. Unimodal performance was first examined when only […]
Mistuning detection performance of ferrets in a go/no-go task
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
Mistuning detection performance of ferrets in a go/no-go task: The harmonic structure of sounds is an important grouping cue in auditory scene analysis. The ability of ferrets to detect mistuned harmonics was measured using a go/no-go task paradigm. Psychometric functions plotting sensitivity as a function of degree of mistuning were used to evaluate behavioral performance […]
Allergy and Immunology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You’ve successfully subscribed to this feed!Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds Today, 28 Ιουνίου 2016, 8:52:55 πμ Regulatory issues in immunity to […]
Squamous cell carcinoma (SCC) – Cancer – Melanoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You’ve successfully subscribed to this feed!Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds Dose-escalation study of tabalumab with bortezomib and dexamethasone in Japanese patients […]
OtoRhinoLaryngology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 32 δευτερόλεπτα
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You’ve successfully subscribed to this feed!Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds Gain The Upperhand-More Political Influence For ASBA Members Today, 28 Ιουνίου […]
International Endodontic Journal
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Clinical Periodontology
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Endodontics
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Esthetic and Restorative Dentistry
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Prosthodontics
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American Journal of Orthodontics and Dentofacial Orthopedics
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The Angle Orthodontist
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Dentistry News
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Dose-escalation study of tabalumab with bortezomib and dexamethasone in Japanese patients with multiple myeloma
[image: cover.gif?v=1&s=cd51c7f7da7776e178cb46d5] Abstract B-cell activating factor (BAFF) promotes the survival and adhesion of multiple myeloma (MM) cells. Tabalumab (LY2127399) is an anti-BAFF monoclonal antibody. This phase 1, multicenter, open-label, nonrandomized, dose-escalation study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of tabalumab in combination with bortezomib and dexamethasone in Japanese patients with relapsed or refractory MM (RRMM). Sixteen patients received intravenous (IV) tabalumab 100 mg (Cohort 1, n=4) or IV taba... περισσότερα »
Family Dentistry and Cosmetic Surgery Clinic
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Nursing & Dentistry
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American Journal of Orthodontics and Dentofacial Orthopedics
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Genetics
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds Spectrum of DNA variants for non-syndromic deafness in a large cohort from multiple continents Yesterday, 27 Ιουνίου 2016, 7:18:50 μμ[image: Go to full article] AbstractHearing loss is the most common sensory deficit in humans with causative variants in over 140 genes. With few exceptions, howev... περισσότερα »
Delayed complications and functional outcome of isolated sternal fracture after emergency department discharge: a prospective, multicentre cohort study
Research Articles Samuel Racine, Marcel Émond, Jean-Sébastien Audette-Côté, Natalie Le Sage, Chantal Guimont, Lynne Moore, Jean-Marc Chauny, Éric Bergeron, Laurent Vanier Canadian Journal of Emergency Medicine,FirstView Article(s), 9 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29iJEwB
Clinical Periodontology
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Endodontics
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You’ve successfully subscribed to this feed! Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds You’ve successfully subscribed to this feed! Journal of Endodontics You […]
Genetic Resistance Determinants for Cefixime and Molecular Analysis of Gonococci Isolated in Italy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Microbial Drug Resistance , Vol. 0, No. 0. from Mary Ann Liebert, Inc. publishers via xlomafota13 on Inoreader http://ift.tt/28ZgMwo via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2902qcB via IFTTT
Esthetic and Restorative Dentistry
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You’ve successfully subscribed to this feed! Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds You’ve successfully subscribed to this feed! Journal of Esthetic and […]
Prosthodontics
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You’ve successfully subscribed to this feed! Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds You’ve successfully subscribed to this feed! Journal of Prosthodontics You […]
Ho:YAG laser,Low-level infrared laser,Pattern Scan Laser photocoagulation,694-nm fractional Q-switched ruby laser (QSRL),Long-pulsed alexandrite laser,Er,Cr:YSGG laser,Confocal tumor thickness,Photodynamic therapy,Photobiomodulation,CO 2 laser,Low-level laser therapy (GaAlAs)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You’ve successfully subscribed to this feed! Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds You’ve successfully subscribed to this feed! Latest Results You are […]
miRNA involvement in angiogenesis in age-related macular degeneration
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Late-stage AMD is characterized by choroidal neovascularization (CNV). miR-93 appears to play a role in regulating vascular endothelial growth factor-A (VEGF-A), a known factor involved in neovascularization. Understanding its biological significance might enable development of therapeutic interventions for diseases like AMD. […]
Satellite cell activation and apoptosis in skeletal muscle from severely burned children
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Severe burns result in profound skeletal muscle atrophy; persistent muscle loss and weakness are major complications that hamper recovery from burn injury. Many factors contribute to the erosion of muscle mass following burn trauma, and we propose that an impaired muscle satellite cell response is key in the etiology of burn-induced cachexia. Muscle biopsies […]
Current Oral Health Reports
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You’ve successfully subscribed to this feed! Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds You’ve successfully subscribed to this feed! Latest Results for Current […]
Dose-escalation study of tabalumab with bortezomib and dexamethasone in Japanese patients with multiple myeloma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract B-cell activating factor (BAFF) promotes the survival and adhesion of multiple myeloma (MM) cells. Tabalumab (LY2127399) is an anti-BAFF monoclonal antibody. This phase 1, multicenter, open-label, nonrandomized, dose-escalation study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of tabalumab in combination with bortezomib and dexamethasone in Japanese patients with relapsed or refractory MM (RRMM). […]
miRNA involvement in angiogenesis in age-related macular degeneration
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Late-stage AMD is characterized by choroidal neovascularization (CNV). miR-93 appears to play a role in regulating vascular endothelial growth factor-A (VEGF-A), a known factor involved in neovascularization. Understanding its biological significance might enable development of therapeutic interventions for diseases like AMD. We aimed to determine the role of miR-93 in AMD using a laser-induced CNV mouse model. CNV was induced by laser photocoagulation in C57BL/6 mice. The CNV mice we... περισσότερα »
The Angle Orthodontist
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Edward H. Angle Society of Orthodontists: The Angle Orthodontist: Table of Contents *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is... περισσότερα »
Dentistry News
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Anticholinergic medicines in an older primary care population: a cross-sectional analysis of medicines’ levels of anticholinergic activity and clinical indications
Summary What is known and objectives Adverse clinical outcomes have been associated with cumulative anticholinergic burden (to which low-potency as well as high-potency anticholinergic medicines contribute). The clinical indications for which anticholinergic medicines are prescribed (and thus the 'phenotype' of patients with anticholinergic burden) have not been established. We sought to establish the overall prevalence of prescribing of anticholinergic medicines, the prevalence of prescribing of low-, medium- and high-potency anticholinergic medicines, and the clinical indication... περισσότερα »
Impact of anti-PEG IgM antibodies on the pharmacokinetics of pegylated asparaginase preparations in mice
Publication date: 25 August 2016 *Source:*European Journal of Pharmaceutical Sciences, Volume 91 Author(s): Sabine M. Poppenborg, Julia Wittmann, Wolfgang Walther, Gunda Brandenburg, Ralf Krähmer, Joachim Baumgart, Frank Leenders The potential impact of pre-existing anti-PEG antibodies on the asparaginase activity kinetics of two pegylated l-asparaginase preparations - pegylated recombinant l-asparaginase (PEG-rASNase MC0609) and pegaspargase (pegylated Escherichia colil-asparaginase) - was investigated in immune competent, naïve B6D2F1-hybrid mice. To generate anti-PEG antibodies, ... περισσότερα »
Clinical Implant Dentistry and Related Research
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Clinical Implant Dentistry and Related Research *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your com... περισσότερα »
Nasotracheal intubation of a patient with restricted mouth opening using a McGrath MAC X-Blade and Magill forceps
Abstract We experienced a case of successful nasotracheal intubation using the X-Blade of the McGrath MAC in a 28-year-old woman with a 2.5-cm mouth opening. She had no teeth on the right side, her neck movement was limited, her mandibular protrusion was grade C, and her Mallampati could not be evaluated. Her tongue was fixed to the left wall during a previous surgery. We evaluated the awake glottic view using the McGrath MAC X-Blade and topical oral anesthesia. We obtained a Cormack-Lehane grade II view and then decided to administer general anesthesia. Intubation was attempted w... περισσότερα »
British Dental Journal
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Orthodontics
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Acta Biomaterialia
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Mechanical Stretching Promotes Skin Tissue Regeneration via Enhancing Mesenchymal Stem Cell Homing and Transdifferentiation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Skin tissue expansion is a clinical procedure for skin regeneration to reconstruct cutaneous defects that can be accompanied by severe complications. The transplantation of mesenchymal stem cells (MSCs) has been proven effective in promoting skin expansion and helping to ameliorate complications; however, systematic understanding of its mechanism remains unclear. MSCs from luciferase-Tg Lewis rats were […]
Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Rho-GTPases have relevant functions in various aspects of neuronal development, such as differentiation, migration, and synaptogenesis. Loss of function of the oligophrenin-1 gene (OPHN1) causes X-linked intellectual disability with cerebellar hypoplasia and leads to hyperactivation of the rho kinase (ROCK) pathway. ROCK mainly acts through phosphorylation of the myosin phosphatase targeting subunit 1, triggering actin-myosin […]
Concise Review: Pancreatic Cancer and Bone Marrow-Derived Stem Cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Pancreatic adenocarcinoma remains one of the most challenging diseases of modern gastroenterology, and, even though considerable effort has been put into understanding its pathogenesis, the exact molecular mechanisms underlying the development and/or systemic progression of this malignancy still remain unclear. Recently, much attention has been paid to the potential role of bone marrow-derived stem cells […]
Stem Cell Surface Marker Expression Defines Late Stages of Reprogramming to Pluripotency in Human Fibroblasts
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Our current understanding of the induction of pluripotency by defined factors indicates that this process occurs in discrete stages characterized by specific alterations in the cellular transcriptome and epigenome. However, the final phase of the reprogramming process is incompletely understood. We sought to generate tools to characterize the transition to a fully reprogramed state. We […]
Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Osteoarthritis (OA) is the most widespread musculoskeletal disorder in adults. It leads to cartilage damage associated with subchondral bone changes and synovial inflammation, causing pain and disability. The present study aimed at evaluating the safety of a dose-escalation protocol of intra-articular injected adipose-derived stromal cells (ASCs) in patients with knee OA, as well as clinical […]
Age-Dependent Effect of Pediatric Cardiac Progenitor Cells After Juvenile Heart Failure
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Children with congenital heart diseases have increased morbidity and mortality, despite various surgical treatments, therefore warranting better treatment strategies. Here we investigate the role of age of human pediatric cardiac progenitor cells (hCPCs) on ventricular remodeling in a model of juvenile heart failure. hCPCs isolated from children undergoing reconstructive surgeries were divided into 3 groups […]
Targeting the cAMP and Transforming Growth Factor-{beta} Pathway Increases Proliferation to Promote Re-Epithelialization of Human Stem Cell-Derived Retinal Pigment Epithelium
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Retinal pigment epithelium (RPE) cell integrity is critical to the maintenance of retinal function. Many retinopathies such as age-related macular degeneration (AMD) are caused by the degeneration or malfunction of the RPE cell layer. Replacement of diseased RPE with healthy, stem cell-derived RPE is a potential therapeutic strategy for treating AMD. Human embryonic stem cells […]
Functional Plasticity of Adipose-Derived Stromal Cells During Development of Obesity
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Obesity is a major risk factor for a number of chronic diseases, including diabetes, cardiovascular diseases, and cancer. Expansion of the adipose mass requires adipocyte precursor cells that originate from multipotent adipose-derived stromal cells (ASCs), which in turn also participate in repair activities. ASC function might decline in a disease milieu, but it remains unclear […]
Embryological Origin of Human Smooth Muscle Cells Influences Their Ability to Support Endothelial Network Formation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Vascular smooth muscle cells (SMCs) from distinct anatomic locations derive from different embryonic origins. Here we investigated the respective potential of different embryonic origin-specific SMCs derived from human embryonic stem cells (hESCs) to support endothelial network formation in vitro. SMCs of three distinct embryological origins were derived from an mStrawberry-expressing hESC line and were cocultured […]
The Neurofilament-Derived Peptide NFL-TBS.40-63 Targets Neural Stem Cells and Affects Their Properties
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Targeting neural stem cells (NSCs) in the adult brain represents a promising approach for developing new regenerative strategies, because these cells can proliferate, self-renew, and differentiate into new neurons, astrocytes, and oligodendrocytes. Previous work showed that the NFL-TBS.40-63 peptide, corresponding to the sequence of a tubulin-binding site on neurofilaments, can target glioblastoma cells, where it […]
Genetic Resistance Determinants for Cefixime and Molecular Analysis of Gonococci Isolated in Italy
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Microbial Drug Resistance , Vol. 0, No. 0. from Mary Ann Liebert, Inc. publishers via xlomafota13 on Inoreader http://ift.tt/28ZgMwo via IFTTT
miRNA involvement in angiogenesis in age-related macular degeneration
Abstract Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Late-stage AMD is characterized by choroidal neovascularization (CNV). miR-93 appears to play a role in regulating vascular endothelial growth factor-A (VEGF-A), a known factor involved in neovascularization. Understanding its biological significance might enable development of therapeutic interventions for diseases like AMD. We aimed to determine the role of miR-93 in AMD using a laser-induced CNV mouse model. CNV was induced by laser photocoagulation in C57BL/6 mice. The CNV mice wer... περισσότερα »
Satellite cell activation and apoptosis in skeletal muscle from severely burned children
Abstract Severe burns result in profound skeletal muscle atrophy; persistent muscle loss and weakness are major complications that hamper recovery from burn injury. Many factors contribute to the erosion of muscle mass following burn trauma, and we propose that an impaired muscle satellite cell response is key in the etiology of burn-induced cachexia. Muscle biopsies from the *m. vastus lateralis* were obtained from 12 male pediatric burn patients (>30% total body surface area burn) and 12 young, healthy male subjects. Satellite cell content, activation and apoptosis were determined... περισσότερα »
Guided bone regeneration using individualized ceramic sheets
Guided bone regeneration (GBR) describes the use of membranes to regenerate bony defects. A membrane for GBR needs to be biocompatible, cell-occlusive, non-toxic, and mouldable, and possess space-maintaining properties including stability. The purpose of this pilot study was to describe a new method of GBR using individualized ceramic sheets to perfect bone regeneration prior to implant placement; bone regeneration was assessed using traditional histology and three-dimensional (3D) volumetric changes in the bone and soft tissue. from #ENT via xlomafota13 on Inoreader http://ift.tt... περισσότερα »
Maternal biomarkers of methylation status and non-syndromic orofacial cleft risk: a meta-analysis
Animal models have shown evidence of the role of maternal methyl donor status and its metabolism (one-carbon metabolism) in normal embryonic maxillofacial development. Nevertheless, studies in humans have shown conflicting results for the association of maternal methylation status biomarkers in the aetiology of the main craniofacial birth defects: non-syndromic orofacial clefts (NSOFCs). The aim of this study was to perform a meta-analysis assessing the relationship between maternal levels of methylation status biomarkers (plasma and erythrocyte folates and plasma vitamin B12 and ... περισσότερα »
The Angle Orthodontist
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Dentistry News
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Clinical Implant Dentistry and Related Research
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Nasotracheal intubation of a patient with restricted mouth opening using a McGrath MAC X-Blade and Magill forceps
Abstract We experienced a case of successful nasotracheal intubation using the X-Blade of the McGrath MAC in a 28-year-old woman with a 2.5-cm mouth opening. She had no teeth on the right side, her neck movement was limited, her mandibular protrusion was grade C, and her Mallampati could not be evaluated. Her tongue was fixed… Continue reading Nasotracheal intubation of a patient with restricted mouth opening using a McGrath MAC X-Blade and Magill forceps
British Dental Journal
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Acta Biomaterialia
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Orthodontics
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Couple Functioning after Pediatric Cancer Diagnosis: A Systematic Review
Abstract Objectives A systematic review was conducted to: 1) investigate couple functioning after a pediatric cancer diagnosis, and 2) examine theoretical and methodological tendencies and issues in this literature. Methods Searches of Web of Science, Pubmed, Cochrane, PsycInfo and Embase resulted in inclusion of 32 qualitative, quantitative or mixed method papers. Findings of these papers… Continue reading Couple Functioning after Pediatric Cancer Diagnosis: A Systematic Review
Physical and Psychological Correlates of High Somatic Symptom Severity in Chinese Breast Cancer Patients
Abstract Objective We researched associations between somatic symptom severity (SSS), physical and psychological factors in Chinese breast cancer patients. Methods This multicenter cross-sectional study enrolled 255 Chinese breast cancer patients of different stages and treatment phases. They answered standard instruments assessing SSS (PHQ-15), depression (PHQ-9), anxiety (GAD-7), health anxiety (WI-7), illness perception (Brief-IPQ), illness attribution… Continue reading Physical and Psychological Correlates of High Somatic Symptom Severity in Chinese Breast Cancer Patients
Physical and Psychological Correlates of High Somatic Symptom Severity in Chinese Breast Cancer Patients
Physical and Psychological Correlates of High Somatic Symptom Severity in Chinese Breast Cancer Patients: Abstract Objective We researched associations between somatic symptom severity (SSS), physical and psychological factors in Chinese breast cancer patients. Methods This multicenter cross-sectional study enrolled 255 Chinese breast cancer patients of different stages and treatment phases. They answered standard instruments assessing… Continue reading Physical and Psychological Correlates of High Somatic Symptom Severity in Chinese Breast Cancer Patients
Dose-escalation study of tabalumab with bortezomib and dexamethasone in Japanese patients with multiple myeloma
[image: cover.gif?v=1&s=cd51c7f7da7776e178cb46d5] Abstract B-cell activating factor (BAFF) promotes the survival and adhesion of multiple myeloma (MM) cells. Tabalumab (LY2127399) is an anti-BAFF monoclonal antibody. This phase 1, multicenter, open-label, nonrandomized, dose-escalation study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of tabalumab in combination with bortezomib and dexamethasone in Japanese patients with relapsed or refractory MM (RRMM). Sixteen patients received intravenous (IV) tabalumab 100 mg (Cohort 1, n=4) or IV taba... περισσότερα »
Nasotracheal intubation of a patient with restricted mouth opening using a McGrath MAC X-Blade and Magill forceps
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract We experienced a case of successful nasotracheal intubation using the X-Blade of the McGrath MAC in a 28-year-old woman with a 2.5-cm mouth opening. She had no teeth on the right side, her neck movement was limited, her mandibular protrusion was grade C, and her Mallampati could not be evaluated. Her tongue was fixed to the left wall during a previous surgery. We evaluated the awake glottic view using the McGrath MAC X-Blade and topical oral anesthesia. We obtained a Cormack-Lehane grade II view and then decided to administer general anesthesia. Intubation was attempted w... περισσότερα »
Nasotracheal intubation of a patient with restricted mouth opening using a McGrath MAC X-Blade and Magill forceps
Abstract We experienced a case of successful nasotracheal intubation using the X-Blade of the McGrath MAC in a 28-year-old woman with a 2.5-cm mouth opening. She had no teeth on the right side, her neck movement was limited, her mandibular protrusion was grade C, and her Mallampati could not be evaluated. Her tongue was fixed to the left wall during a previous surgery. We evaluated the awake glottic view using the McGrath MAC X-Blade and topical oral anesthesia. We obtained a Cormack-Lehane grade II view and then decided to administer general anesthesia. Intubation was attempted w... περισσότερα »
Evaluation of the artificial membrane permeability of drugs by digital simulation
Publication date: 25 August 2016 *Source:*European Journal of Pharmaceutical Sciences, Volume 91 Author(s): Mayumi Nakamura, Toshiyuki Osakai A digital simulation method has been developed for evaluating the membrane permeability of drugs in the parallel artificial membrane permeation assay (PAMPA). The simulation results have shown that the permeability coefficient (log Ppampa) of drugs is linearly increased with increasing their distribution coefficient (log KD,M) to the lipid membrane, i.e., the hydrophobicity of the drug molecules. However, log Ppampa shows signs of leveling off... περισσότερα »
Delayed complications and functional outcome of isolated sternal fracture after emergency department discharge: a prospective, multicentre cohort study
Research Articles Samuel Racine, Marcel Émond, Jean-Sébastien Audette-Côté, Natalie Le Sage, Chantal Guimont, Lynne Moore, Jean-Marc Chauny, Éric Bergeron, Laurent Vanier Canadian Journal of Emergency Medicine,FirstView Article(s), 9 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29iJEwB via IFTTT
Dental filling Tooth Filling Cavity Filling Silver Filling Longview WA
The post Dental filling Tooth Filling Cavity Filling Silver Filling Longview WA appeared first on Family Dentistry and Cosmetic Surgery Clinic. http://ift.tt/2921SFy http://ift.tt/28Zdauv
Gain The Upperhand-More Political Influence For ASBA Members
There is no doubt that the Presidential election has been on the forefront of political news this year. The latest on the subject mentioned by multiple media outlets surround the possibility of Former Arizona Governor Jan Brewer joining Donald Trump's national ticket as the vice-presidential pick. So where is the connection to members of the American Sleep and Breathing Academy (ASBA)? David Gergen, Executive Director of the ASBA, has remained close friends with Jan Brewer and the family for decades including the duration of her six year service to Arizona. This adds to the already... περισσότερα »
Risk Factors for Implant Failure and Peri-Implant Pathology in Systemic Compromised Patients
Abstract Purpose To identify the possible risk factors for implant failure and peri-implant pathology in a population of systemically compromised patients. Materials and Methods This retrospective clinical study included a total of 721 systemically compromised patients (422 women, 299 men), with an average age of 51 years (range: 20 to 87) rehabilitated with dental implants.… Continue reading Risk Factors for Implant Failure and Peri-Implant Pathology in Systemic Compromised Patients
Penetrating Craniomaxillofacial Injury Caused by a Pneumatic Nail Gun
Cranial Maxillofac Trauma Reconstruction DOI: 10.1055/s-0036-1584405 Craniomaxillofacial injuries can be complex, requiring a multidisciplinary approach. The primary survey is always the first step in trauma management prior to proceeding with further evaluation and treatment. A 26-year-old man presented with a penetrating nail gun injury through the oral and nasal cavities. He did not present in… Continue reading Penetrating Craniomaxillofacial Injury Caused by a Pneumatic Nail Gun
Maternal biomarkers of methylation status and non-syndromic orofacial cleft risk: a meta-analysis
Animal models have shown evidence of the role of maternal methyl donor status and its metabolism (one-carbon metabolism) in normal embryonic maxillofacial development. Nevertheless, studies in humans have shown conflicting results for the association of maternal methylation status biomarkers in the aetiology of the main craniofacial birth defects: non-syndromic orofacial clefts (NSOFCs). The aim of… Continue reading Maternal biomarkers of methylation status and non-syndromic orofacial cleft risk: a meta-analysis
Guided bone regeneration using individualized ceramic sheets
Guided bone regeneration (GBR) describes the use of membranes to regenerate bony defects. A membrane for GBR needs to be biocompatible, cell-occlusive, non-toxic, and mouldable, and possess space-maintaining properties including stability. The purpose of this pilot study was to describe a new method of GBR using individualized ceramic sheets to perfect bone regeneration prior to… Continue reading Guided bone regeneration using individualized ceramic sheets
Three-dimensional fracture pattern analysis of the Obwegeser and Dal Pont bilateral sagittal split osteotomy
The Obwegeser and Dal Pont modification of the bilateral sagittal split osteotomy (BSSO) is a well-established procedure in orthognathic surgery. The purpose of this retrospective study was to analyze the actual fracture patterns achieved with BSSO by Obwegeser and Dal Pont modification using postoperative cone beam computed tomography (CBCT) datasets from 100 patients. A total… Continue reading Three-dimensional fracture pattern analysis of the Obwegeser and Dal Pont bilateral sagittal split osteotomy
Satellite cell activation and apoptosis in skeletal muscle from severely burned children
Abstract Severe burns result in profound skeletal muscle atrophy; persistent muscle loss and weakness are major complications that hamper recovery from burn injury. Many factors contribute to the erosion of muscle mass following burn trauma, and we propose that an impaired muscle satellite cell response is key in the etiology of burn-induced cachexia. Muscle biopsies… Continue reading Satellite cell activation and apoptosis in skeletal muscle from severely burned children
Comparison of Cervical Proprioception in Individuals with and without Latent Myofascial Trigger points
2016-06-27T18-25-37Z Source: International Journal of Therapies and Rehabilitation Research Deepa Abichandani, Meghna Mehta. Background:Myofascial trigger points are an extremely common cause of pain. Purpose: Primarily to associate the presence of latent MTP in upper trapezius in individuals and their effect on cervical proprioception Methods: 60 women, 20-35 years of age were assessed via a pressure… Continue reading Comparison of Cervical Proprioception in Individuals with and without Latent Myofascial Trigger points
Prognosis Discussions Improve Understanding of Illness for Patients with Terminal Cancer
Prognosis Discussions Improve Understanding of Illness for Patients with Terminal Cancer: New study results show that many patients with advanced, incurable cancer have a poor understanding of their prognosis or life expectancy. Fewer than one in four patients in the study reported having a recent discussion about prognosis with their oncologist, although those who did… Continue reading Prognosis Discussions Improve Understanding of Illness for Patients with Terminal Cancer
Tinnitus Cures That Work
If you are a victim of tinnitus, you know how frustrating it can be. Tinnitus is a condition that causes a ringing or buzzing in the ears. It can also be described as a hissing, clicking, or roaring sound that you hear all the time. It is not produced by any external source. Tinnitus is… Continue reading Tinnitus Cures That Work
L-DOPA-induced hyperhomocysteinemia in Parkinson’s disease: Elephant in the room
Publication date: September 2016 Source:Biochimica et Biophysica Acta (BBA) – General Subjects, Volume 1860, Issue 9 Author(s): Rajib Paul, Anupom Borah BackgroundDopamine replacement therapy by its precursor, L-3.4-dihydroxyphenylalanine (L-DOPA), has been the treatment of choice for Parkinson’s disease. However, the possible contributory effect of L-DOPA therapy on the progression of Parkinson’s disease mediated by the… Continue reading L-DOPA-induced hyperhomocysteinemia in Parkinson’s disease: Elephant in the room
Gain The Upperhand-More Political Influence For ASBA Members
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
There is no doubt that the Presidential election has been on the forefront of political news this year. The latest on the subject mentioned by multiple media outlets surround the possibility of Former Arizona Governor Jan Brewer joining Donald Trump’s national ticket as the vice-presidential pick. So where is the connection to members of the […]
Dental filling Tooth Filling Cavity Filling Silver Filling Longview WA
The post Dental filling Tooth Filling Cavity Filling Silver Filling Longview WA appeared first on Family Dentistry and Cosmetic Surgery Clinic. http://ift.tt/2921SFy from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28ZZs8Y via IFTTT
Comparison between completely and traditionally retroperitoneoscopic nephroureterectomy for upper tract urothelial cancer
Comparison between completely and traditionally retroperitoneoscopic nephroureterectomy for upper tract urothelial cancer: Abstract Background To evaluate the safety and efficacy of the completely retroperitoneoscopic nephroureterectomy (CRNU), a retrospectively comparative study between completely and traditionally retroperitoneoscopic nephroureterectomy (TRNU) was done in a single center. Methods From January 2014 to December 2014, 107 patients with upper tract urothelial cancer (UTUC) underwent CRNU. The kidney was retroperitoneoscopically dissected and the bladder cuff was c... περισσότερα »
Comparison of Cervical Proprioception in Individuals with and without Latent Myofascial Trigger points
2016-06-27T18-25-37Z *Source:* International Journal of Therapies and Rehabilitation Research Deepa Abichandani, Meghna Mehta. Background:Myofascial trigger points are an extremely common cause of pain. Purpose: Primarily to associate the presence of latent MTP in upper trapezius in individuals and their effect on cervical proprioception Methods: 60 women, 20-35 years of age were assessed via a pressure algometer and cervical range of motion of motion machine Results: It was found that the individuals with latent trigger points showed a higher deviation error than individuals withou... περισσότερα »
Risk Factors for Implant Failure and Peri-Implant Pathology in Systemic Compromised Patients
Abstract Purpose To identify the possible risk factors for implant failure and peri-implant pathology in a population of systemically compromised patients. Materials and Methods This retrospective clinical study included a total of 721 systemically compromised patients (422 women, 299 men), with an average age of 51 years (range: 20 to 87) rehabilitated with dental implants. The average follow-up time was 7.3 years. The patients' demographic variables (age and gender) and clinical variables (implant location, type of implant surface, and systemic conditions) were recorded. Outcom... περισσότερα »
Three-dimensional fracture pattern analysis of the Obwegeser and Dal Pont bilateral sagittal split osteotomy
The Obwegeser and Dal Pont modification of the bilateral sagittal split osteotomy (BSSO) is a well-established procedure in orthognathic surgery. The purpose of this retrospective study was to analyze the actual fracture patterns achieved with BSSO by Obwegeser and Dal Pont modification using postoperative cone beam computed tomography (CBCT) datasets from 100 patients. A total of 200 split osteotomies were assessed, which could be categorized into nine different split patterns. Only one of the observed split fractures (0.5%) followed exactly the fracture line described by Obweges... περισσότερα »
Penetrating Craniomaxillofacial Injury Caused by a Pneumatic Nail Gun
Cranial Maxillofac Trauma Reconstruction DOI: 10.1055/s-0036-1584405 Craniomaxillofacial injuries can be complex, requiring a multidisciplinary approach. The primary survey is always the first step in trauma management prior to proceeding with further evaluation and treatment. A 26-year-old man presented with a penetrating nail gun injury through the oral and nasal cavities. He did not present in extremis but required elective endotracheal intubation for intraoperative assessment and treatment. Airway management was enhanced by the use of lingual nerve and inferior alveolar nerve b... περισσότερα »
Maternal biomarkers of methylation status and non-syndromic orofacial cleft risk: a meta-analysis
Animal models have shown evidence of the role of maternal methyl donor status and its metabolism (one-carbon metabolism) in normal embryonic maxillofacial development. Nevertheless, studies in humans have shown conflicting results for the association of maternal methylation status biomarkers in the aetiology of the main craniofacial birth defects: non-syndromic orofacial clefts (NSOFCs). The aim of this study was to perform a meta-analysis assessing the relationship between maternal levels of methylation status biomarkers (plasma and erythrocyte folates and plasma vitamin B12 and ... περισσότερα »
Guided bone regeneration using individualized ceramic sheets
Guided bone regeneration (GBR) describes the use of membranes to regenerate bony defects. A membrane for GBR needs to be biocompatible, cell-occlusive, non-toxic, and mouldable, and possess space-maintaining properties including stability. The purpose of this pilot study was to describe a new method of GBR using individualized ceramic sheets to perfect bone regeneration prior to implant placement; bone regeneration was assessed using traditional histology and three-dimensional (3D) volumetric changes in the bone and soft tissue. http://ift.tt/28ZDB0T http://ift.tt/293FsEC from... περισσότερα »
Modified alar base cinch suture fixation at the bilateral lower border of the piriform rim after a maxillary Le Fort I osteotomy
Classic cinch suture narrowing of the nasal alar base by medially suturing the bilateral nasolabial soft tissue with one long suture has a limited effect. The modified cinch method described in the present study anchors non-absorbable sutures to the bilateral lower border of the piriform rim and provides optimal direction, position, and stability. The sutures can be shortened and the strength kept stable while the surgical wounds heal. Separate bilateral sutures can also reduce interference and distortion from nasotracheal intubation and make the nasolabial profile more symmetrical... περισσότερα »
Regulatory issues in immunity to liver and blood-stage malaria
Natalija Van Braeckel-Budimir | Samarchith P Kurup | John T Harty from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/28ZNzQB from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28YVIWY via IFTTT
Risk Factors for Implant Failure and Peri-Implant Pathology in Systemic Compromised Patients
Abstract Purpose To identify the possible risk factors for implant failure and peri-implant pathology in a population of systemically compromised patients. Materials and Methods This retrospective clinical study included a total of 721 systemically compromised patients (422 women, 299 men), with an average age of 51 years (range: 20 to 87) rehabilitated with dental implants. The average follow-up time was 7.3 years. The patients' demographic variables (age and gender) and clinical variables (implant location, type of implant surface, and systemic conditions) were recorded. Outcom... περισσότερα »
