Help-Seeking Behaviors and Intimate Partner Violence-Related Traumatic Brain Injury

Violence and Gender, Ahead of Print.


https://ift.tt/2p5kAC3

Intensity-Modulated Radiation Therapy With or Without Concurrent Chemotherapy in Nonanaplastic Thyroid Cancer with Unresectable or Gross Residual Disease

Thyroid, Volume 28, Issue 9, Page 1180-1189, September 2018.


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Radioiodine Refractory Differentiated Thyroid Cancer: Time to Update the Classifications

Thyroid, Volume 28, Issue 9, Page 1083-1093, September 2018.


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Effect of Buparlisib, a Pan-Class I PI3K Inhibitor, in Refractory Follicular and Poorly Differentiated Thyroid Cancer

Thyroid, Volume 28, Issue 9, Page 1174-1179, September 2018.


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Das Myxödemherz: The Myxedema Heart Herman Zondek 1887–1979

Thyroid, Volume 28, Issue 9, Page 1079-1080, September 2018.


https://ift.tt/2N82jm5

South Korean Thyroid Cancer Trends: Good News and Bad

Thyroid, Volume 28, Issue 9, Page 1081-1082, September 2018.


https://ift.tt/2Mw9KOO

Future Meetings

Thyroid, Volume 28, Issue 9, Page 1224-1225, September 2018.


https://ift.tt/2NesHuv

Sonographically Estimated Risks of Malignancy for Thyroid Nodules Computed with Five Standard Classification Systems: Changes over Time and Their Relation to Malignancy

Thyroid, Volume 28, Issue 9, Page 1190-1197, September 2018.


https://ift.tt/2MrmWUZ

Novel variant of reversed midgut rotation – retro-arterial proximal jejunum and transverse colon: a case report and review of the literature

Reversed rotation of the midgut is the rarest variation of midgut malrotations, which are congenital disorders that result from aberrant rotation and fixation of the midgut during embryological development. Co...

https://ift.tt/2xaLBZo

Fifth Euro‐Asian Congress of Dermatovenereologists, Riga, Latvia

Dermatologic Therapy, EarlyView.


https://ift.tt/2x97V5s

First case of secukinumab successful therapy in a very elderly psoriatic patient

Dermatologic Therapy, EarlyView.


https://ift.tt/2CRYCfq

Issue Information

Oral Diseases, Volume 24, Issue 7, Page 1143-1144, October 2018.


https://ift.tt/2p35HQJ

Cover Image

Oral Diseases, Volume 24, Issue 7, Page i-i, October 2018.


https://ift.tt/2Oh3kop

Traditional face-bow transfer versus three-dimensional virtual reconstruction in orthognathic surgery

Face-bow transfer is an essential step in articulator-based orthognathic surgery planning. However, it can be a source of inaccuracy. Virtual computer-based planning avoids this error through the use of direct patient-related three-dimensional imaging data. The aim of this prospective observational study was to determine the error of face-bow transfer three-dimensionally and correlate it to the different types of malocclusion. Orthognathic surgery performed on 38 patients (10 male, 28 female; mean (standard deviation) age 24.7 (6.9) years) was planned twice: first articulator-based with plaster models and second computer-based with surgery planning software.

https://ift.tt/2D25UO6

Manufacture of a high definition ocular prosthesis

Disfigurement associated with enucleations and eviscerations can have considerable physical, social, and emotional impacts on a patient.1 As many as 18% of patients who wear orbital prostheses experience clinical depression and anxiety, and a further 21% have reported that they avoid being seen in public.2

https://ift.tt/2NaNf7e

Margins and survival in oral cancer

In the surgical management of oral squamous cell carcinoma (SCC) we aim to resect the tumour with clear margins in all planes. The aim of this study was to identify and compare overall survival in a group of 591 patients who had resections, and to relate this to the clearance of margins at the tumour bed. We used life tables to calculate survival at one, two, three, five, and 10 years after diagnosis by margin (clear=5mm or more; close=2–5mm; and involved=less than 2mm). Kaplan–Meier curves were produced for the margins alone, which were defined as clear in 480 patients (81%), close in 63 (11%), and involved in 48 (8%).

https://ift.tt/2xcLont

Neurosensory recovery after trauma to the orbital floor: a prospective trial with dexamethasone

Our aims were to document the occurrence of neurosensory disturbances of the infraorbital nerve six months after operation for an orbital blow-out fracture, and to find out whether dexamethasone facilitates neurosensory regeneration. Patients were randomly assigned to one of two groups: the study group was given a total of dexamethasone 30mg, whereas the control group were given neither glucocorticoid nor placebo. Each patient's infraorbital neurosensory state was recorded preoperatively, immediately postoperatively, and six months later.

https://ift.tt/2N9gbfL

The impact and effect of emotional resilience on performance: an overview for surgeons and other healthcare professionals

Medicine and surgery can be demanding professions with high levels of burnout, but few healthcare professionals are given training or education in the management of stress, and the ability of individuals to cope with work and other pressures is often taken for granted. Emotional resilience – the ability to recover from a stressful event, whether at work or at home – is influenced by factors that are both within and outside our control. In this review, we provide an overview of emotional resilience for surgeons and other healthcare professionals, and focus on the factors that can be modulated to help us cope with difficult or complex situations.

https://ift.tt/2xeYiBl

Primary reconstruction of orbital fractures using patient-specific titanium milled implants: the Helsinki protocol

Preoperative virtual planning and the use of patient-specific implants enable exact reconstruction of orbital fractures. We present our results and experience of reconstruction of isolated orbital fractures with patient-specific implants, according to the Helsinki protocol, in 15 patients who were followed up for at least three months postoperatively. The mean (range) difference between the positions of virtually planned, and postoperative, implants was 1.9 (0.5–5.6) mm. The postoperative volume of the fractured orbit was 1.34ml less than that of the non-fractured side, but this was not clinically relevant.

https://ift.tt/2NfkcQ8

Inflammasome, interleukine 1, maladies auto-inflammatoires et dermatoses neutrophiliques

Publication date: Available online 13 September 2018

Source: Annales de Dermatologie et de Vénéréologie

Author(s): M.-S. Doutre

https://ift.tt/2CTucJN

Review of outcomes of 500 consecutive cases of non-melanoma skin cancer of the head and neck managed in an oral and maxillofacial surgical unit in a District General Hospital

Publication date: Available online 13 September 2018

Source: British Journal of Oral and Maxillofacial Surgery

Author(s): A.J. Dalal, J. Ingham, B. Collard, G. Merrick

Abstract

We provide a non-melanoma skin cancer (NMSC) service for skin cancers of the head and neck in the south-west of England. We hypothesised that certain anatomical sites such as the nose and eyelid would have a higher incidence of close or involved margins than others, and that the choice of repair might influence the excised margins. We therefore retrospectively analysed the data of 500 consecutive NMSC that were operated on in the oral and maxillofacial surgery unit of Taunton and Somerset NHS Trust. The database reports were crosschecked against the Trust's own pathology reporting system to ensure that they were accurate. Data collected included clinical and personal details of patients, anatomical sites, type of reconstruction, histopathological diagnosis, excision margins, and complications. Of the 500 patients reviewed 362 (72%) were basal cell carcinomas (BCC) and 138 (28%) squamous cell carcinomas (SCC). The outcomes of 243 patients treated by primary closure, 134 treated by reconstruction with local flaps, and 123 treated by skin grafts, were reviewed with particular attention paid to the anatomical site and excision margins. There was an overall incomplete excision rate of 10.8% (n = 54) and 29 patients developed complications (5.8%). We confirmed that rates of close or incomplete margins are more likely in certain anatomical sites such as the nose, forehead, and ear. The rate of involved margins was unaffected by choice of surgical technique.

https://ift.tt/2MmByFj

Is Improved Insurance Coverage a Fleeting Opportunity?

The data from the Surveillance, Epidemiology, and End Results (SEER) database analyzed by Cannon et al in this issue of JAMA Otolaryngology–Head & Neck Surgery are highly relevant as the future of the Patient Protection and Affordable Care Act (ACA) becomes progressively more fragile. The authors provide objective data on improved rates of health care coverage after implementation of the ACA among patients with head and neck cancer. Reviewing the evolving payer mix is an important metric when assessing access to care. The decline in uninsured patients with head and neck cancer from 6.2% in 2013 to 3.0% in 2014 is a significant improvement. This finding does not mean that increased coverage is inexpensive, uniformly successful, or synonymous with improved patient adherence to treatment and healthier living. Although SEER survival outcomes data are not yet available for comparison of the periods before and after implementation of the ACA, this article is an important catalyst in our specialty for future study of the influence that major health policy change has on patients with head and neck cancer.

https://ift.tt/2p2D9Xw

A Parathyroid Hemangioma of the Retropharynx

This case report describes a man in his 30s who presented with cluster headaches and migraines and was subsequently diagnosed with retropharyngeal parathyroid hemangioma.

https://ift.tt/2CR7sdu

Association of the ACA With Insurance Coverage for Head and Neck Cancer

This population-based study uses data from the Surveillance, Epidemiology, and End Results database to examine the association of the Patient Protection and Affordable Care Act with rates of insurance coverage and access to care among patients with head and neck squamous cell cancer.

https://ift.tt/2p66lwK

FDG PET–CT in the Detection of Oropharyngeal Cancer Recurrence

This cohort study compares the accuracies of the initial posttreatment positron emission tomography and computed tomography between primary treatment groups and attempts to define indicators of false-positive findings in patients treated for oropharyngeal cancer.

https://ift.tt/2CRPV4R

Ultrasonographic Evaluation of Upper Airway Structures in Children With Obstructive Sleep Apnea

This single-center, observational study of children with sleep-disordered breathing measures the upper airway structures using head and neck ultrasonography and evaluates the association between these measurements and severity of obstructive sleep apnea seen on polysomnography.

https://ift.tt/2p6tuPM

Pediatric Laryngeal Expression and Surgical Treatment of IgG4-Related Disease

This case report describes a previously healthy female child who presented with several months of hoarseness, globus sensation, and dysphagia and was subsequently diagnosed with a rare form of IgG4-related disease.

https://ift.tt/2CRPM1j

Atypical Infraglottic Lesion

A cigarette smoker in his 50s with a history of hypertension, chronic kidney disease, colon adenocarcinoma, and hyperuricemia presented with an asymptomatic right vocal fold mass found incidentally during esophagogastroduodenoscopy; he denied fevers or weight loss. What is your diagnosis?

https://ift.tt/2p3ZtjF

Vitamin D deficiency are associated with subjective disease severity in Chinese patients with chronic rhinosinusitis with nasal polyps

Publication date: Available online 13 September 2018

Source: American Journal of Otolaryngology

Author(s): Feng Wang, Yang Yang, Haihong Chen

Abstract

Objective

To evaluate the serum vitamin D level in patients with chronic rhinosinusitis with nasal polyps and its correlation with the disease severity.

Setting

Hospital of Zhejiang University.

Study design

Retrospective analysis of collected data.

Subjects and methods

Patients with chronic rhinosinusitis with or without nasal polyps who underwent endoscopic sinus surgery were recruited. Demographic information including age, gender, body mass index, smoke history, atopic status and asthma was collected. Disease severity was measured by the Lund-Mackay CT score and Sino-Nasal Outcome Test-22 score. Serum 25-hydroxyvitamin D3 was measured by enzyme-linked immunosorbent assay preoperatively.

Results

Serum 25-hydroxyvitamin D3 levels were significantly lower in patients with nasal polyps (CRSwNP, 38.2 ± 9.1 nmol/L; CRSsNP, 48.94 ± 12.1 nmol/L; control, 54.1 ± 17.1 nmol/L. p < 0.001), and the levels were significantly associated with the preoperative Sino-Nasal Outcome Test-22 score (p = 0.013), but not with the Lund-Mackay score (p = 0.126). Furthermore, serum 25-hydroxyvitamin D3 levels were associated with the subjective improvement six months postoperatively (p < 0.001),

Conclusion

Serum 25-hydroxyvitamin D3 levels are lower in Chinese CRSwNP patients. These 25-hydroxyvitamin D3 levels are associated with SNOT-22 score. Preoperative 25-hydroxyvitamin D3 level may impact on the symptom improvement after surgery.

https://ift.tt/2xkEUTV

Ultrasound guided superior laryngeal nerve block as an adjuvant to generalanesthesia during endoscopic laryngeal surgery: A prospective, randomized, double-blind trial

Publication date: Available online 13 September 2018

Source: American Journal of Otolaryngology

Author(s): Rupavath Ramkumar, Suman Arora, Nidhi Bhatia, Sandeep Bansal

Abstract

Introduction

Blindly administered bilateral (B/L) superior laryngeal nerve (SLN) blocks, have been used to decrease the perioperative stress response of endoscopic laryngosurgeries. Use of ultrasound (USG) for giving these blocks is more likely to be successful, with fewer complications. We evaluated the efficacy of USG guided B/L SLN block in decreasing perioperative cough, sore-throat and hoarseness of voice.

Material and methods

This study was conducted on forty patients undergoing endoscopic laryngosurgery under GA. Patients were randomized into two groups of 20 patients each. Patients in group C received GA, whereas those in group L received USG-guided SLN block bilaterally with 2.5 ml of 2% lignocaine, along with GA. Postoperative cough, sore throat and hoarseness of voice was measured at 30 min, 2 h, 4 h and 24 h following transfer to post-anesthesia care unit.

Results

Patients receiving SLN block had significantly lower incidence of perioperative cough (20% in group L vs 90% in group C; p value - 0.0001) as well as sore throat (5% in group L vs 95% in group C; p value - 0.0001). In these patients, severity of hoarseness of voice was greater in the early postoperative period (100% in group L vs 70% in group C; p value - 0.027), while it decreased significantly at 24 h postoperatively(0.0% in group L vs 30% in group C; p value - 0.027).

Conclusion

USG guided SLN block as an adjuvant to GA resulted in better recovery profile of the patients with significant reduction in postoperative cough, sore throat and hoarseness of voice.

https://ift.tt/2NbcA0T

Internal carotid artery dissection causing pulsatile tinnitus

Publication date: Available online 13 September 2018

Source: American Journal of Otolaryngology

Author(s): Stephanie Y. Chen, Gregory J. Zipfel, Cameron C. Wick

https://ift.tt/2xkEGMz

Differential effects of postoperative oral corticosteroid on eosinophilic vs. non-eosinophilic CRSwNP subtypes

Publication date: Available online 13 September 2018

Source: American Journal of Otolaryngology

Author(s): Kuang-Hsuan Shen, Yu-Hsuan Wang, Ting-Wei Hsu, Li-Chun Hsieh, Fang-Ju Sun, Ying-Piao Wang

Abstract

Purpose

The efficacy of postoperative oral corticosteroids on surgical outcomes in chronic rhinosinusitis with nasal polyps (CRSwNP) patients following endoscopic sinus surgery (ESS) remains controversial. This study evaluated the potential benefits of postoperative oral corticosteroids on surgical outcomes in CRSwNP patients and investigated the differential effects on eosinophilic CRSwNP (ECRSwNP) and noneosinophilic CRSwNP (NECRSwNP).

Materials and methods

Patients with bilateral CRSwNP who underwent ESS were enrolled and randomized to receive either oral prednisolone (30 mg/day) or placebo for 2 weeks after surgery. Visual analog scale (VAS) and Sino-Nasal Outcome Test 22 (SNOT-22) scores were chosen as the subjective outcomes, evaluated at preoperative baseline and 1, 3, and 6 months postoperatively. Lund-Kennedy Endoscopic Scores (LKESs) were used as the objective outcome, evaluated at preoperative baseline and at 2 weeks and 2, 3, and 6 months postoperatively.

Results

In total, 100 patients with bilateral CRSwNP were enrolled, of whom only 82 completed the 6-month follow-up. The subjective outcomes showed no significant difference at each follow-up points. Of the objective outcomes, the corticosteroid group reporting a trend of improvement in LKESs at 6 months postoperatively (p = 0.05). After stratification by tissue eosinophils, only patients with NECRSwNP (<10 eosinophils/HPF) demonstrated a significant improvement in LKESs at 3 months postoperatively (p = 0.03).

Conclusions

Postoperative oral corticosteroids did not provide additional improvements in VAS and SNOT-22 scores; nevertheless, a trend of LKES improvement was noted at 6 months postoperatively. After stratification by tissue eosinophils, this effect was significant only among NECRSwNP patients at 3 months follow-up.

https://ift.tt/2NdNfUd

Anterior Canal benign paroxysmal positional Vertigo following surgical Management of superior canal dehiscence

Publication date: Available online 12 September 2018

Source: American Journal of Otolaryngology

Author(s): Richard A. Roberts, Alejandro Rivas, Kathryn F. Makowiec

Abstract

Objective

Benign paroxysmal positional vertigo (BPPV) is a common post-surgical finding in patients managed for superior semicircular canal dehiscence (SSCD). The posterior semicircular canal has been reported as the involved canal in the majority of cases of post-surgical BPPV, with only two cases reported of lateral canal involvement. The objective of this report is to present a case in which an anterior semicircular canal BPPV response was identified in a patient following surgical management for SSCD.

Method

This case report presents an adult with residual dizziness following surgical management of SSCD and vestibular rehabilitation therapy (VRT). During subsequent evaluation of vestibular function, a transient and torsional, down-beating nystagmus was provoked along with vertigo during Dix-Hallpike positioning to the right. This was consistent with BPPV affecting the left superior (anterior) semicircular canal.

Results

The patient was treated with a repositioning maneuver to manage anterior semicircular canal BPPV and no nystagmus response was recorded with post-repositioning Dix-Hallpike test. Review of radiographic images, obtained prior to vestibular function testing, showed a hyperintensity in the area of the left anterior semicircular canal ampulla. It was felt this was likely a bone chip from the SSCD repair that was pushing against the ampulla with further mobile debris within the canal.

Conclusion

It is reported that BPPV is a common complication in patients surgically managed for SSCD. Posterior semicircular canal BPPV is reported most often, with a couple of cases of lateral semicircular canal BPPV also reported. As far as we are aware, the current case represents the first report of anterior semicircular canal BPPV in this type of patient.

https://ift.tt/2xgjOGe

Sialendoscopy under conscious sedation versus general anesthesia. A comparative study

Publication date: Available online 12 September 2018

Source: American Journal of Otolaryngology

Author(s): Naif Bawazeer, Jean Carvalho, Idir Djennaoui, Anne Charpiot

Abstract

Objective

Sialendoscopy is a minimally invasive emerging approach, the general surgical technique has been published but many essential questions still need to be addressed with the aim of improving outcomes. For instance, should we systematically perform sialendoscopy under conscious sedation (CS) or general anesthesia (GA)? What are the limitations of CS? The objective of this study is to compare these two modalities.

Methodology

A retrospective study of 70 patients who had undergone a sialendoscopy between 2014 and 2016 (34 under GA and 36 under CS). Comparisons were made between these two groups in term of operative time, stone size and location, tolerability, operative success and post-operative pain.

Result

The patients' mean age was 45.33 years. The operative success rate among the GA group was 79.4% vs. 88.9% in the CS group (P = 0.276), while complications for both groups were comparable. All patients considered the intervention under CS to be tolerable.

Conclusion

Sialendoscopy under CS or GA demonstrated the ability to access large and distal stones among the different salivary glands with an excellent tolerability. Anesthesia type should be based on surgeon and patient preference Nevertheless, patient reassurance and surgeon experience are important to producing a good result with CS.

https://ift.tt/2NeCa5i

Honey can help in herpes simplex gingivostomatitis in children: Prospective randomized double blind placebo controlled clinical trial

Publication date: Available online 12 September 2018

Source: American Journal of Otolaryngology

Author(s): Osama G. Abdel-Naby Awad, Abdel-Monem H. Hamad

Abstract

Purpose

Herpes simplex gingivostomatitis (HSGS) in children is a common painful infectious disease. This study aims to examine the combined efficacy of honey with acyclovir suspension compared to acyclovir alone for treating HSGS in young children.

Material and methods

This Randomized double blind placebo controlled study was conducted from June 2015 to September 2017 in a tertiary referral hospital. One hundred children aged 2–8 years with HSGS were randomly classified into 2 groups; study group: treated with honey plus oral acyclovir and control group: treated with oral acyclovir alone. Severity of oral lesions, Fever, eating and drinking ability, pain scores and need for analgesics were compared between 2 groups on day 3, 5 and 7 after starting treatment.

Results

Children receiving honey plus acyclovir (i.e. study group) had significantly earlier disappearance of herpetic oral lesions; median 3 days vs. 6 days in control group (P = 0.022), drooling; 2 days vs. 4 days (P = 0.030) and eating difficulty; 3 days vs. 8 days (P = 0.001). Study group also had significantly lower pain scores, better eating and drinking ability and significantly less need for analgesics at 3 time-points of assessment. Fever disappeared in both groups with no statistically significant difference.

Conclusions

The combined use of honey with oral acyclovir can produce favorable outcome than acyclovir alone in children with Primary herpetic gingivostomatitis.

https://ift.tt/2xaRxRm

Laryngopharyngeal reflux in obstructive sleep apnoea patients: Literature review and meta-analysis

Publication date: Available online 12 September 2018

Source: American Journal of Otolaryngology

Author(s): Giuseppe Magliulo, Giannicola Iannella, Antonella Polimeni, Marco De Vincentiis, Giuseppe Meccariello, Giampiero Gulotta, Benedetta Pasquariello, Filippo Montevecchi, Andrea De Vito, Giovanni D'agostino, Riccardo Gobbi, Giovanni Cammaroto, Claudio Vicini

Abstract

Purpose

Laryngopharyngeal reflux (LPR) is a frequent condition in Obstructive Sleep Apnoea (OSA) patients and different studies have been published in the last years about this topic. A review of the published literature regarding LPR in OSA patients has been reported. A meta-analysis to evaluate the incidence of LPR in OSA patients and correlate LPR positivity with OSA patients' characteristics has been performed.

Methods

A comprehensive review of the English language literature about LPR in OSA patients was performed using the most important electronic databases (PubMed, EMBASE, the Cochrane Library etc.). A total of 10 papers studying LPR in OSA were assessed and considered eligible for the meta-analysis.

Results

The data analysis regarding 870 identified OSA patients showed that 394 patients were LPR +, while 476 were LPR-. The meta-analysis showed no statistical difference regarding the AHI value between LPR + patients and LPR- patients (p = 0,3). Mean BMI was more higher in LPR + patients than in the patients without LPR, showing a significant statistical difference (p = 0.001).

Conclusion

Current international literature demonstrates a high incidence of LPR (45.2%) in OSA patients. The severity of AHI in OSA patients would not seem to correlate with the presence of laryngopharyngeal reflux. The OSA patients with LPR showed a higher BMI compared with LPR- patients.

https://ift.tt/2N7fpQq

Temperature and depth evaluation of the in vitro effects of femtosecond laser on oral soft tissue, with or without air-cooling

Abstract

Femtosecond laser is an effective and safe tool in many surgeries, but the studies of its effect on oral soft tissue ablation are insufficient. This study aimed to investigate the effect of soft tissue ablation with a 1030-nm femtosecond laser on temperature and depth. Twenty Sprague–Dawley rat tongue specimens were obtained and flat-mounted. The 1030-nm femtosecond laser was controlled by a computer system, with a set distance of 4.7 mm between the laser aperture and soft tissue surfaces. Ten specimens were ablated for > 1 min with or without air-cooling for temperature measurement, while the other 10 specimens were ablated for depth measurements, using the following parameters: (i) 3 W, 2000 mm/s; (ii) 3 W, 4000 mm/s; (iii) 5 W, 2000 mm/s; (iv) 5 W, 4000 mm/s; (v) 8 W, 2000 mm/s; (vi) 8 W, 4000 mm/s. Temperature changes were measured using a type-K thermocouple. The depth attained using different power and scanning speed settings was measured by a three-dimensional morphology measurement laser microscope. Laser power, scanning speed, and air-cooling effects were determined. Higher energy and lower speed induced higher temperatures (p < 0.05), which were significantly decreased by air-cooling (p < 0.05). The lowest ablation depth was obtained at 3 W and 4000 mm/s (72.63 ± 6.47 μm) (p < 0.05). The greatest incision depth was achieved at 8 W and 2000 mm/s (696.19 ± 35.37 μm), or 4000 mm/s (681.16 ± 55.65 μm) (p < 0.05). The 1030-nm femtosecond laser application demonstrates clinically acceptable ablation efficiency, without marked temperature damage, in a controlled manner.

https://ift.tt/2N6MzQh

Er,Cr:YSGG laser associated with acidulated phosphate fluoride gel (1.23% F) for prevention and control of dentin erosion progression

Abstract

To evaluate the effect of Er,Cr:YSGG laser, associated with fluoride application, on the prevention/control of dentin erosion. Dentin slabs were embedded in acrylic resin, flattened, and polished. Half of the specimens were previously eroded (10 min immersion in 1% citric acid solution) and half were kept sound. The specimens (n = 10 each substrate) were randomly allocated into the experimental groups, according to the following treatments: control (no treatment); APF gel (1.23% F, 1 min); Er,Cr:YSGG laser irradiation (P1: 0.25 W, 20 Hz, 2.8 J/cm², tip S75, beam diameter of 750 μm, 1 mm away from the surface); Er,Cr:YSGG laser irradiation (P2: 0.50 W, 20 Hz, 5.7 J/cm², tip S75, beam diameter of 750 μm, 1 mm away from the surface); APF gel + Er,Cr:YSGG laser P1 and; APF gel + Er,Cr:YSGG laser P2. Afterwards, the specimens underwent an erosion-remineralization cycling, consisting of a 5-min immersion into 0.3% citric acid, followed by 60-min exposure to artificial saliva. This procedure was repeated 4×/day, for 5 days. Surface loss (SL, in μm) was determined by optical profilometry. Specimens from each group were analyzed by environmental scanning electron microscopy (n = 3). Data were statistically analyzed (α = 0.05). For the eroded specimens, APF gel presented the lowest SL, being different from the control. For the sound specimens, none of the groups differed from the control, except for Er,Cr:YSGG laser P2, which presented the highest SL. When substrates were compared, only the eroded specimens of the control and APF + Er,Cr:YSGG laser P1 Groups showed higher SL. Selective structure removal was observed for the laser-treated groups. None of the Er,Cr:YSGG laser parameters were effective in the prevention/control dentin erosion. The laser was also unable to enhance the protection of fluoride against dentin erosion.

https://ift.tt/2Oi3tYP

Evaluation of theranostic perspective of gold-silica nanoshell for cancer nano-medicine: a numerical parametric study

Abstract

Using gold-silica nanoshell as a reference nano-agent, this work has performed preliminary numerical parametric study to investigate the feasibility and if feasible the efficiency of using a single nano-agent to achieve theranostic goals. In total, seven generics of gold-silica nanoshells have been tested including the R[50,10] (radius of the silica core is 50 nm and thickness of the gold shell is 10 nm), R[40,15], R[55,25], R[40,40], R[75,40], R[104,23], and R[154,24] nanoshells. A planar tissue model has been constructed as the platform for parametric study. For mathematical modeling, radiant transport equation (RTE) has been applied to describe the interactions among laser lights, the hosting tissue, and the hosted nanoshells and Penne's bio-heat equation has been applied to describe the hyperthermia induced by such interactions. Effects of different nanoshell generics on the diffuse reflectance signal and hyperthermia temperature transition have been simulated, basing on which the potential of a certain nanoshell generic as theranostic nano-agent has been evaluated. It has been found that it is highly feasible for gold-silica nanoshells to be engineered for theranostic purpose and nanoshell generics that are preferentially scattering should be explored for good theranostic candidates. On the condition that nanoshell generic with the right optical properties has been located, a moderate nanoshell retention in the target tissue site is already sufficient to induce effective theranostic effects, which indicates that theranostic nano-medicine might not have a stringent requirement for the delivery technique. Among nanoshells that have been tested, the R[55,25] nanoshell seems to be a promising candidate as theranostic nano-agent. Further testing on it is highly recommended. Nanoshells that are preferentially absorbing such as the R[50,10] and R[40,15] nanoshells are efficient photothermal agent and could be used for therapeutic purpose only. However, it is not recommended that preferentially absorbing nanoshells being used for theranostic purpose due to possible negative effects such nanoshells might bring to the diffuse reflectance signal.

https://ift.tt/2N8xMV7

Hörgeräteversorgung im Kindesalter

Zusammenfassung

Die Hörgeräteversorgung im Kindesalter stellt eine Herausforderung für alle Fachdisziplinen dar. Nach den Qualitätsvereinbarungen ist eine vergleichende Anpassung und Erprobung vor der Verordnung zwingend erforderlich. Auch die regelmäßigen Überprüfungen der Hörgeräteeinstellungen mittels In-situ- oder RECD(„real ear to coupler difference")-Messung und Einstellungsoptimierung sind als Standard in der Kinderversorgung anzustreben. HNO-Ärzte, Phoniater und Pädaudiologen, Pädakustiker (Kinderhörgeräteakustiker), Schwerhörigen- und Sonderpädagogen sollten dabei interdisziplinär zusammenarbeiten.

https://ift.tt/2xfJnXE

Intralymphatic allergen immunotherapy against pollen allergy: A 3-year open follow-up study of 10 patients

Publication date: Available online 13 September 2018

Source: Annals of Allergy, Asthma & Immunology

Author(s): Lars Ahlbeck, Emelie Ahlberg, Ulla Nyström, Janne Björkander, Maria C. Jenmalm

https://ift.tt/2MqFNjf

Food-induced anaphylaxis in infants and children

Publication date: September 2018

Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3

Author(s): Waheeda Samady, Jennifer Trainor, Bridget Smith, Ruchi Gupta

Abstract

Background

Recent recommendations to introduce peanut products to infants for peanut allergy prevention requires a focused assessment of infant anaphylaxis.

Objective

This study describes the symptomatology of food-induced anaphylaxis (FIA) in infants (<12 months) compared with older pediatric cohorts.

Methods

Retrospective review between June 2015 and June 2017 of children presenting with FIA at a large urban children's hospital emergency department (ED).

Results

A total of 357 cases of FIA were evaluated: 47 in infants (<12 months), 43 in toddlers (12-24 months), 96 in young children (2-6 years), and 171 in school-aged children (>6 years). Infants presented with gastrointestinal (GI) involvement more frequently than any other age group (89% vs 63% [P = .003], 60% [P < .001], and 58% [P < .001]). Additionally, infants and young children presented with skin involvement more frequently than school-aged children (94% and 91% vs 62% [P < .001]). Respiratory symptoms were more common in older cohorts (17% in infants vs 44% in young children [P < .001] and 54% in school-aged children [P < .001]). Egg and cow's milk were more common causes of FIA in infants compared with school-aged children (egg, 38% vs 1% [P < .001]; milk, 17% vs 7% [P = .03]). Only 21% of infants with FIA had eczema, and 36% had a history of food allergy.

Conclusion

Infants with FIA primarily presented with GI and skin manifestations. Egg was the most common food trigger in infants. Most infants with FIA did not have eczema or a history of food allergy.

https://ift.tt/2N9ZUal

Hepatitis B vaccine nonresponders: Possible mechanisms and solutions

Publication date: September 2018

Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3

Author(s): Tara Vinyette Saco, Alexandra T. Strauss, Dennis K. Ledford

Abstract

Objective

Hepatitis B (HBV) is a viral illness that chronically infects 240 million people worldwide, leads to liver disease, and increases risk of hepatocellular carcinoma. The HBV vaccine has decreased HBV infection, and it and the human papilloma virus vaccine are the only vaccines that prevent cancer. Despite the effectiveness of the HBV vaccine, some populations do not develop protective responses. The risk groups for poor response include those with immunosuppression or dialysis-dependent, end-stage renal disease. Five percent of normal people do not have a response. These subjects are deemed HBV "nonresponders." Multiple strategies to improve the immunogenicity of the HBV vaccine are currently being pursued, including vaccine adjuvants, recombinant vaccines, and immune enhancement via up-regulation of dendritic cells.

Data Sources

PubMed was searched for peer-reviewed publications published from January 1980 to September 2017.

Study Selections

Studies retrieved for inclusion summarized potential mechanisms behind HBV vaccine nonresponsiveness and potential solutions.

Results

The mechanisms behind HBV vaccine nonresponsiveness vary between each subject population. Many current and future strategies may provide protective immunity against HBV in each of these populations.

Conclusion

This review provides a background on the immunology of HBV infection, the possible immunologic mechanisms to explain HBV vaccine nonresponsiveness, current research aimed at improving vaccine effectiveness, and possible future approaches for providing nonresponders protection from HBV.

https://ift.tt/2MqFGUR

Hidden allergens in food allergy

Publication date: September 2018

Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3

Author(s): Mary Grace Baker, Sarah Saf, Angela Tsuang, Anna Nowak-Wegrzyn

https://ift.tt/2N85RVo

New diagnostic criteria for eosinophilic esophagitis: Will they influence our practice?

Publication date: September 2018

Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3

Author(s): Mirna Chehade

https://ift.tt/2MseVPz

Life in the FAST lane

Publication date: September 2018

Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3

Author(s): Matthew Greenhawt, John J. Oppenheimer

https://ift.tt/2N7yJx4

Allergen immunotherapy

Publication date: September 2018

Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3

Author(s): John Oppenheimer, Gailen D. Marshall

https://ift.tt/2MqFuF7

Editorial Board

Publication date: September 2018

Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3

Author(s):

https://ift.tt/2Nc7GAw

Information for Authors

Publication date: September 2018

Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3

Author(s):

https://ift.tt/2MseEMx

Table of Contents

Publication date: September 2018

Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3

Author(s):

https://ift.tt/2Nc7vVS

Information for Readers

Publication date: September 2018

Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3

Author(s):

https://ift.tt/2Msercd

Diane E. Schuller, MD (1943–2018)

Publication date: September 2018

Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3

Author(s): Joseph A. Bellanti

https://ift.tt/2Nb8Ufp

Pilot study of the CAPS (Clinical extent, Area, Pruritus, Sleep) measure for atopic dermatitis severity

Publication date: September 2018

Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3

Author(s): Aaron M. Drucker, Natalie H. Matthews, Jennie Muglia, Abrar A. Qureshi

Keywords

Eczema; Atopic dermatitis; Outcome measures; Severity; Symptoms; Itch

Abbreviations: AD, atopic dermatitis; BSA, body surface area; CAPS, Clinical extent, Area, Pruritus, Sleep; DLQI, Dermatology Life Quality Index; EASI, Eczema Area and Severity Index; IGA, Investigator Global Assessment; POEM, Patient-Oriented Eczema Measure

https://ift.tt/2MqEZuJ

Development of food protein–induced enterocolitis syndrome (FPIES) to egg after immunoglobulin E–mediated egg allergy

Publication date: September 2018

Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3

Author(s): Hannah Duffey, Maureen Egan

https://ift.tt/2N8V3qe

Erratum

Publication date: September 2018

Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 3

Author(s):

https://ift.tt/2MqEReJ

Hyaluronic acid accelerates bone repair in human dental sockets: a randomized triple-blind clinical trial

Abstract This study evaluated the effects of hyaluronic acid (HA) on bone repair of human dental sockets. Thirty-two lower first premolars were extracted from 16 patients (2 per patient) for orthodontic reasons. Following the extractions, one socket was randomly filled with 1% HA gel, while the other was allowed to naturally fill with blood clot. After 30 and 90 days of surgery, patients underwent cone beam computed tomography. Five central orthoradial slices were captured from each socket. The gray intensity was measured in each image and results were reported as mean percentage of bone formation. The buccolingual alveolar ridge width was measured and dimensional changes were compared between the postoperative intervals. The pattern of alveolar trabecular bone was evaluated through the fractal dimension. Treated sockets showed a higher percentage of bone formation and fractal dimension values (58.17% and 1.098, respectively) compared with controls (48.97% and 1.074, respectively) in the 30-day postoperative period (p < 0.05). After 90 days, there was no significant difference between groups. Additionally, no significant difference was found between groups regarding the alveolar dimensions (p > 0.05). Use of 1% HA gel after tooth extraction accelerates bone repair in human dental sockets.

https://ift.tt/2p4qHGE

Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue

Abstract Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) act in the proteolysis of basement membrane and extracellular matrix structures, facilitating tumor invasion. The purpose of this study was to evaluate the relationship between these proteins and clinicopathological parameters in squamous cell carcinoma of the oral tongue (SCCOT). Sixty cases of SCCOT were submitted to immunohistochemistry and analyzed semiquantitatively at the invasion front and in the tumor core. The results were associated with lymph node metastasis, clinical stage, locoregional recurrence, clinical outcome and histological grade of malignancy. A higher expression of uPA was observed in cases of tumors of high-grade versus low-grade malignancy (p = 0.010). Moreover, the cases with the worst pattern of invasion presented an overexpression of uPA (p = 0.011). The presence of locoregional recurrence was associated with uPAR (p = 0.039), and the expression of both biomarkers was much higher at the invasion front than in the tumor core (p < 0.001). The results suggest uPA and uPAR are involved in the progression and aggressiveness of SCCOT, mainly at the tumor-host interface.

https://ift.tt/2D0OD7Y

Evaluation of the efficacy of filling material removal and re-filling after different retreatment procedures

Abstract This study analyzed the influence of different retreatment protocols on amount of remaining filling material and amount of new sealer after endodontic retreatment. Forty mandibular molars with curved mesial roots were prepared with ProTaper Universal system, and filled with AH Plus sealer mixed with 0.1% rhodamine B and gutta-percha. After 7 days, the specimens were randomized according to the retreatment protocol (n = 10): ProTaper Retreatment System (PTR); PTR+Orange Oil (PTR+OO); PTR+Passive Ultrasonic Irrigation (PTR+PUI). No retreatment was performed in the control group (CG). After retreatment, the root canals were filled with AH Plus mixed with 0.1% fluorescein and gutta-percha. Samples were evaluated under confocal laser scanning microscopy and analyzed using Image J software. Data were analyzed using Kruskal-Wallis and Dunn tests (p < 0.05). Regarding presence of residual filling, the Kruskal-Wallis test indicated no differences among the different retreatment techniques in the perimeter and the isthmus analyses (p > 0.05); however, PTR+PUI was associated with a lesser amount of residual filling material in the canal area analysis (p < 0.05). In evaluating the new filling, the perimeter analysis showed a lesser amount of new endodontic sealer in the PTR group (p < 0.05). Moreover, the PTR+PUI group presented a significantly greater amount of new endodontic sealer in the canal area analysis (p < 0.05). There was no difference among groups in the isthmus analysis (p > 0.05). It can be concluded that PTR associated to PUI yielded better results in removing root canal filling material from the canal area. However, none of the protocols resulted in root walls completely free of remnants.

https://ift.tt/2pbg6Kp

Short implants versus longer implants with maxillary sinus lift. A systematic review and meta-analysis

Abstract This study compared the survival rate of dental implants, amount of marginal bone loss, and rates of complications (biological and prosthetic) between short implants and long implants placed after maxillary sinus augmentation. This systematic review has been registered at PROSPERO under the number (CRD42017073929). Two reviewers searched the PubMed/MEDLINE, Embase, LILACS, and Cochrane Library databases. Eligibility criteria included randomized controlled trials, comparisons between short implants and long implants placed after maxillary sinus augmentation in the same study, and follow-up for >6 months. The Cochrane Collaboration's tool for assessing the risk of bias in randomized trials was used to assess the quality and risk of bias of the included studies. The search identified 1366 references. After applying the inclusion criteria, 11 trials including 420 patients who received 911 dental implants were considered eligible. No significant difference was observed in the survival rate [p = 0.86; risk ratio (RR): 1.08; 95% confidence interval (CI): 0.46–2.52] or in the amount of marginal bone loss (p = 0.08; RR: −0.05; 95%CI: −0.10 to 0.01). However, higher rates of biological complications for long implants associated with maxillary sinus augmentation were observed (p < 0.00001; RR: 0.21; 95%CI: 0.10–0.41), whereas a higher prosthetic complication rate for short implants was noted (p = 0.010; RR: 3.15; 95%CI: 1.32–7.51). Short implant placement is an effective alternative because of fewer biological complications and similar survival and marginal bone loss than long implant placement with maxillary sinus augmentation. However, the risk of mechanical complications associated with the prostheses fitted on short implants should be considered.

https://ift.tt/2COiL6h

A Randomized Phase 2 Study of Cemiplimab ± ISA101b in HPV16-Positive OPC

Conditions:   Squamous Cell Carcinoma of the Oropharynx;   HPV16 Positive
Interventions:   Biological: ISA101b;   Drug: Cemiplimab;   Other: Placebo
Sponsors:   ISA Pharmaceuticals;   Regeneron Pharmaceuticals
Not yet recruiting

https://ift.tt/2x6QAu7

Pilot Study of Somatostatin Receptor Imaging in Nasopharyngeal Cancer

Condition:   Nasopharyngeal Carcinoma
Intervention:  
Sponsors:   National Cancer Centre, Singapore;   Singapore General Hospital;   A*Star
Recruiting

https://ift.tt/2D49jfl

To Study the Impact of Radiation Treatment After Surgery in Patient With Locally Advanced Thyroid Cancer.

Conditions:   Thyroid Cancer Stage IV;   Radiation Toxicity
Interventions:   Radiation: Intensity Modulated Radiotherapy;   Procedure: Surgery alone
Sponsors:   Tata Memorial Hospital;   Department of Atomic Energy
Recruiting

https://ift.tt/2x9VruB

Reduced-dose Radiotherapy for Low-risk Stage III Patients With Nasopharyngeal Carcinoma

Condition:   Nasopharyngeal Carcinoma
Interventions:   Radiation: Intensity-modulated radiation therapy;   Drug: Paclitaxel liposome;   Drug: Cisplatin;   Drug: 5-Fluorouracil
Sponsor:   Sun Yat-sen University
Not yet recruiting

https://ift.tt/2CPY4Hd

Cabozantinib beim fortgeschrittenen hepatozellulären Karzinom

https://ift.tt/2QmvrUy

Loss of transforming growth factor-β1 in epithelium cells affects enamel formation in mice

Publication date: Available online 12 September 2018

Source: Archives of Oral Biology

Author(s): Wenying Song, Yanli Wang, Qing Chu, Congcong Qi, Yuehua Gao, Yan Gao, Lili Xiang, Xu Zhenzhen, Yuguang Gao

Abstract

Objectives

In order to understand the specific in vivo function of transforming growth factor-beta1 (TGF-β1), we successfully established aTGF-β1 deficient mouse model using a conditional knockout method. In the present study, we aimed to further understand the potential role of TGF-β1 in enamel formation.

Design

Transgenic mice withoutTGF-β1 in epithelial cells were generated. Scanning electron microscopy and micro-computed tomography analysis were used to detect the dental appearance, enamel microstructure and tooth density. Histological analysis was used to examine the residual organic matrix of enamel. Quantitative real-time polymerase chain reaction was used to analyze the expressions of enamel matrix proteins at the mRNA level.

Results

The enamel of mandibular molars and incisors inTGF-β1 conditional knockout mice displayed severe attrition and lower density compared with the wild-type littermates. A slender microstructure of enamel rod was observed, and enamel matrix proteins were retained in the enamel space at the maturation stage in conditional knockout mice. Moreover, the expressions of enamel matrix protein-encoding genes, such as amelogenin (Amelx), ameloblastin (Ambn), Enamelin (Enam) and matrix metalloproteinase-20 (Mmp-20), were increased in enamel organs of conditional knockout mice. On the other hand, the expressions of Amelotin (Amtn), kallikrein-related peptidase-4 (Klk4), C4orf26 and WD repeat-containing protein 72 (Wdr72) were dramatically decreased at the transition and maturation stages.

Conclusions

TGF-β1 played an important role in enamel mineralization through decreasing synthesis ofAmelx, Ambn and Enam and increasing synthesis of Klk4, Amtn, Corf26 and Wdr72.

https://ift.tt/2CR946Z

Masticatory hypofunction effects induced by BTXA injection of hippocampal neurons in developing rats

Publication date: Available online 12 September 2018

Source: Archives of Oral Biology

Author(s): Chi-Yang Tsai, Hsin-Ping Lee, Hung-Ming Chang, Fang-Chun Wu

Abstract

Background and objective

In clinical practice, malocclusion is often encountered during the period of growth and development of individuals. In addition to nutritional imbalance, some studies have found that mastication affects learning and memory ability. Tooth loss and masticatory hypofunction have been suggested as risk factors of Alzheimer disease. However, relatively little research has been done in developing animals. The present study evaluated the relationship between masticatory hypofunction and neuropathological changes of the hippocampus in developing rats.

Design

Four-week-old Wistar rats were randomly divided into saline-injected and botulinum toxin type A (BTXA)-injected groups. After an experiment period of 4 weeks, the rats were sacrificed for evaluation of neuropathological changes in the hippocampus through Nissl staining and phosphorylated cyclic AMP (cAMP) response element binding protein (CREB) immunohistochemistry.

Results

Nissl staining revealed a significant reduction in the density of neurons in the BTXA-injected rats. The BTXA-injected rats exhibited a decreased level of CREB phosphorylation. The degree of p-CREB immunoreactivity differed significantly between the two groups.

Conclusion

The BTXA-injected rats exhibited a reduction in neuron density and phosphorylated CREB, indicating that mastication might influence the learning and memory ability during the growth period. Therefore, it is strongly suggested that malocclusion be corrected as soon as possible during growth and development.

https://ift.tt/2x9yebD

Loss of transforming growth factor-β1 in epithelium cells affects enamel formation in mice

Publication date: Available online 12 September 2018

Source: Archives of Oral Biology

Author(s): Wenying Song, Yanli Wang, Qing Chu, Congcong Qi, Yuehua Gao, Yan Gao, Lili Xiang, Xu Zhenzhen, Yuguang Gao

Abstract

Objectives

In order to understand the specific in vivo function of transforming growth factor-beta1 (TGF-β1), we successfully established aTGF-β1 deficient mouse model using a conditional knockout method. In the present study, we aimed to further understand the potential role of TGF-β1 in enamel formation.

Design

Transgenic mice withoutTGF-β1 in epithelial cells were generated. Scanning electron microscopy and micro-computed tomography analysis were used to detect the dental appearance, enamel microstructure and tooth density. Histological analysis was used to examine the residual organic matrix of enamel. Quantitative real-time polymerase chain reaction was used to analyze the expressions of enamel matrix proteins at the mRNA level.

Results

The enamel of mandibular molars and incisors inTGF-β1 conditional knockout mice displayed severe attrition and lower density compared with the wild-type littermates. A slender microstructure of enamel rod was observed, and enamel matrix proteins were retained in the enamel space at the maturation stage in conditional knockout mice. Moreover, the expressions of enamel matrix protein-encoding genes, such as amelogenin (Amelx), ameloblastin (Ambn), Enamelin (Enam) and matrix metalloproteinase-20 (Mmp-20), were increased in enamel organs of conditional knockout mice. On the other hand, the expressions of Amelotin (Amtn), kallikrein-related peptidase-4 (Klk4), C4orf26 and WD repeat-containing protein 72 (Wdr72) were dramatically decreased at the transition and maturation stages.

Conclusions

TGF-β1 played an important role in enamel mineralization through decreasing synthesis ofAmelx, Ambn and Enam and increasing synthesis of Klk4, Amtn, Corf26 and Wdr72.

https://ift.tt/2CR946Z

Effectiveness and acid/tooth brushing resistance of in-office desensitizing treatments—A hydraulic conductance study

Publication date: Available online 12 September 2018

Source: Archives of Oral Biology

Author(s): Samira Helena João-Souza, Alana Cristina Machado, Raquel Mariana Lopes, Denise Maria Zezell, Tais Scaramucci, Ana Cecília Corrêa Aranha

Abstract

Objective

To evaluate dentin permeability and tubule occlusion of in-office desensitizing treatments, and to analyze their resistance to erosive/abrasive challenges.

Design

Ninety-one 1mm-thick dentin discs were immersed in EDTA solution for 5 min. After analyzing the maximum dentin permeability, the specimens were randomly allocated into 7 experimental groups (n = 10): Control (no treatment); Er,Cr:YSGG laser; Nd:YAG laser; Gluma Desensitizer ; Duraphat; Pro-Argin toothpaste; Calcium Sodium Phosphosilicate (CSP) paste. The post-treatment permeability was assessed and then the specimens were subjected to a 5-day erosion-abrasion cycling protocol: 4x/day of immersion in citric acid solution (5 min;0.3%), followed by exposure to clarified human saliva (60 min). After the first and last acid challenges, specimens were brushed for 15 s, with exposure to the toothpaste slurry for total time of 2 min. Dentin permeability was re-measured (post-cycling). Percentage of dentin permeability for each experimental time was calculated in relation to the maximum permeability (%Lp). Data were analyzed with 2-way repeated measures ANOVA and Tukey tests (α = 0.05). Surface modifications were analyzed by scanning electron microscopy.

Results

In both experimental time CSP paste and Gluma Desensitizer did not differ from each other (p = 0.0874), and were the only groups that presented significantly lower %Lp than the Control (p = 0.026 and p = 0.022, respectively). After treatment, they were able to reduce dentin permeability in 82% and 72%, respectively. The %Lp post-cycling was higher than post-treatment value for all groups (p = 0.008). Dentin permeability increased 21% for CSP paste and 12% for Gluma, but they remained significant different from Control. Deposits on the surface were observed for CSP paste; and for Gluma, tubule diameters were shown to be smaller.

Conclusions

CSP paste and Gluma Desensitizer were the only treatments able to decrease dentin permeability post-treatment and to sustain low permeability post-cycling.

https://ift.tt/2CSvwg8

Masticatory hypofunction effects induced by BTXA injection of hippocampal neurons in developing rats

Publication date: Available online 12 September 2018

Source: Archives of Oral Biology

Author(s): Chi-Yang Tsai, Hsin-Ping Lee, Hung-Ming Chang, Fang-Chun Wu

Abstract

Background and objective

In clinical practice, malocclusion is often encountered during the period of growth and development of individuals. In addition to nutritional imbalance, some studies have found that mastication affects learning and memory ability. Tooth loss and masticatory hypofunction have been suggested as risk factors of Alzheimer disease. However, relatively little research has been done in developing animals. The present study evaluated the relationship between masticatory hypofunction and neuropathological changes of the hippocampus in developing rats.

Design

Four-week-old Wistar rats were randomly divided into saline-injected and botulinum toxin type A (BTXA)-injected groups. After an experiment period of 4 weeks, the rats were sacrificed for evaluation of neuropathological changes in the hippocampus through Nissl staining and phosphorylated cyclic AMP (cAMP) response element binding protein (CREB) immunohistochemistry.

Results

Nissl staining revealed a significant reduction in the density of neurons in the BTXA-injected rats. The BTXA-injected rats exhibited a decreased level of CREB phosphorylation. The degree of p-CREB immunoreactivity differed significantly between the two groups.

Conclusion

The BTXA-injected rats exhibited a reduction in neuron density and phosphorylated CREB, indicating that mastication might influence the learning and memory ability during the growth period. Therefore, it is strongly suggested that malocclusion be corrected as soon as possible during growth and development.

https://ift.tt/2x9yebD

Effectiveness and acid/tooth brushing resistance of in-office desensitizing treatments—A hydraulic conductance study

Publication date: Available online 12 September 2018

Source: Archives of Oral Biology

Author(s): Samira Helena João-Souza, Alana Cristina Machado, Raquel Mariana Lopes, Denise Maria Zezell, Tais Scaramucci, Ana Cecília Corrêa Aranha

Abstract

Objective

To evaluate dentin permeability and tubule occlusion of in-office desensitizing treatments, and to analyze their resistance to erosive/abrasive challenges.

Design

Ninety-one 1mm-thick dentin discs were immersed in EDTA solution for 5 min. After analyzing the maximum dentin permeability, the specimens were randomly allocated into 7 experimental groups (n = 10): Control (no treatment); Er,Cr:YSGG laser; Nd:YAG laser; Gluma Desensitizer ; Duraphat; Pro-Argin toothpaste; Calcium Sodium Phosphosilicate (CSP) paste. The post-treatment permeability was assessed and then the specimens were subjected to a 5-day erosion-abrasion cycling protocol: 4x/day of immersion in citric acid solution (5 min;0.3%), followed by exposure to clarified human saliva (60 min). After the first and last acid challenges, specimens were brushed for 15 s, with exposure to the toothpaste slurry for total time of 2 min. Dentin permeability was re-measured (post-cycling). Percentage of dentin permeability for each experimental time was calculated in relation to the maximum permeability (%Lp). Data were analyzed with 2-way repeated measures ANOVA and Tukey tests (α = 0.05). Surface modifications were analyzed by scanning electron microscopy.

Results

In both experimental time CSP paste and Gluma Desensitizer did not differ from each other (p = 0.0874), and were the only groups that presented significantly lower %Lp than the Control (p = 0.026 and p = 0.022, respectively). After treatment, they were able to reduce dentin permeability in 82% and 72%, respectively. The %Lp post-cycling was higher than post-treatment value for all groups (p = 0.008). Dentin permeability increased 21% for CSP paste and 12% for Gluma, but they remained significant different from Control. Deposits on the surface were observed for CSP paste; and for Gluma, tubule diameters were shown to be smaller.

Conclusions

CSP paste and Gluma Desensitizer were the only treatments able to decrease dentin permeability post-treatment and to sustain low permeability post-cycling.

https://ift.tt/2CSvwg8

Th17 and Treg lymphocytes in obesity and Type 2 diabetic patients

Publication date: Available online 13 September 2018

Source: Clinical Immunology

Author(s): Mei Wang, Fuqiong Chen, Jingli Wang, Zhixuan Zeng, Qin Yang, Shiying Shao

Abstract

Assumption that the pathogenesis of obesity-associated type 2 diabetes (T2DM) encompasses inflammation and autoimmune aspects is increasingly recognized. In the state of obesity and T2DM, the imbalance of T helper 17 (Th17) cells and regulatory T (Treg) cells are observed. These alterations reflect a loss of T cell homeostasis, which may contribute to tissue and systemic inflammation and immunity in T2DM. In this review we will discuss the accumulating data supporting the concept that Th17/Treg mediated immune responses are present in obesity-related T2DM pathogenesis, and provide evidences that restoration of Th17/Treg imbalance may be a possible therapeutic avenue for the prevention and treatment of T2DM and its complications.

https://ift.tt/2Ojrqie

Mentorship: An Essential Element in Oral and Maxillofacial Surgery Education

Publication date: Available online 13 September 2018

Source: Journal of Oral and Maxillofacial Surgery

Author(s): Mina D. Fahmy

https://ift.tt/2MqlNgF

Relationship Between Nasal Fracture and Blowout Fracture: Can Nasal Fracture be a Predictor of Blowout Fracture?

Publication date: Available online 13 September 2018

Source: Journal of Oral and Maxillofacial Surgery

Author(s): Tae gon Kim, Bong gyu Choi, Jin Ho Lee, Kyu-Jin Chung, Jun Ho Lee, Yong-Ha Kim

Abstract

Background

Nasal and blowout fractures are the most common injuries due to craniomaxillofacial trauma. Nasal fractures are easily diagnosed by clinical signs such as pain and crepitus. However, blowout fractures are frequently asymptomatic and are easy to miss without computed tomography (CT) scan. This study was aimed at analyze the relationship between the two fractures to determine if nasal fracture can be used as a predictor of blowout fracture.

Methods

CT scans of 1368 patients who underwent reduction surgery of nasal fracture were retrospectively reviewed. The patterns of nasal fractures (n=1368) were classified as frontal or lateral type, according to the direction of impact. Blowout fractures (n=297) were classified into three types according to the position of the fractures: medial, inferior, and inferomedial wall. After calculating the number of patients in each group, the relationship between types of nasal and blowout fractures was statistically analyzed.

Results

Of 305 patients with frontal-type nasal fractures, the incidence of medial-, inferior-, and inferomedial-wall fractures was 26, 7, and 9, respectively. Of 1063 patients with lateral-type nasal fractures, the incidence of medial-, inferior-, and inferomedial-wall fractures was 118, 75, and 62, respectively. Medial-wall fracture was most common among both types of nasal fracture groups and is associated with a higher frequency in the lateral-type group.

Conclusions

This study revealed a strong relationship between nasal fractures and medial-wall blowout fractures. If nasal fracture is suspected, especially the lateral type, thorough examination for medial-wall blowout fracture, with a high index of suspicion.

https://ift.tt/2x51jVK

Reproductive Guidance Through Prenatal Diagnosis and Genetic Counseling for Recessive Hereditary Hearing Loss in High-risk Families

Publication date: Available online 12 September 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Deng Yuyuan, Sang Shushan, Wen Jie, Liu Yalan, Ling Jie, Chen Hongsheng, Cai Xinzhang, Mei Lingyun, Chen Xiaoya, Li Meng, Li Wu, Li Taoxi, He Chufeng, Feng Yong

Abstract

Objective

To evaluate the accuracy and validity of our protocol for prenatal diagnosis and genetic counseling in high-risk families at a clinic.

Methods

Fifteen unrelated families with recessive nonsyndromic hearing loss (NSHL) in their family history and a positive attitude towards prenatal diagnosis were recruited in the present study. According to genetic information for each family, Sanger sequencing, fluorescence polymerase chain reaction (PCR)-based congenital deafness gene detection kit and multiple PCR-based target gene capture and high-throughput sequencing were used. Genetic counseling was offered to all participating families by genetic counselors and otologists. Prenatal diagnosis was provided to families with detected pathogenic mutations and who were expected to participate in subsequent prenatal diagnosis.

Results

In this study, confirmed pathogenic mutations were detected in eight families, who were defined as high-risk families. These families all participated in prenatal diagnosis with positive attitudes. One novel variant (c.1687dupA) in the SLC264 gene was detected in a family. Through genetic counseling, the recurrence probability of NSHL in fetuses was 25% in six families, 0% in one family, and 50% in one family. The results of fetal DNA detection showed that one fetal variant was wild type, three were heterozygous mutations in SLC26A4, and one was a compound heterozygous mutation in SLC26A4. Two variants were heterozygous mutations in GJB2, and one was a homozygous mutation in GJB2. According to the test results for fetal DNA, prenatal diagnosis found that six fetuses had normal hearing, whereas two fetuses suffered from NSHL. After birth, six infants predicted to have normal hearing passed a newborn hearing screening test and two infants predicted to have NSHL were diagnosed with NSHL and received cochlear implants.

Conclusion

Our protocol for prenatal diagnosis and genetic counseling provides detailed information that can assist couples in high-risk families in preparing for infant arrival and future family planning. For the affected neonates, prenatal diagnosis and genetic counseling achieve an "early screening, early diagnosis, early intervention" strategy.

https://ift.tt/2MuincR

State of the art: Rehabilitation of speech and swallowing after total laryngectomy

Publication date: November 2018

Source: Oral Oncology, Volume 86

Author(s): Joseph Zenga, Tessa Goldsmith, Glenn Bunting, Daniel G. Deschler

Abstract

Despite the development and expansion of non-surgical organ preservation therapy, total laryngectomy continues to be the optimal therapy for far-advanced local disease and the only curative option for radiotherapy failures not amenable to partial laryngeal procedures. Laryngectomy, however, remains a life-altering operation with profound effects on swallowing and speech. In the nearly 150 years since the first total laryngectomy was performed, few ablative aspects have changed, but reconstructive techniques have undergone radical evolution. This review will trace the origins of laryngeal rehabilitation for voice and swallowing, the current state of the art with attention to pre-treatment considerations and post-operative management, current surgical management techniques, and the future of functional laryngeal reconstruction.

https://ift.tt/2xa2tzc

Modification of the eight-edition tumor-node-metastasis staging system with N1b for papillary thyroid carcinoma: A multi-institutional cohort study

Publication date: November 2018

Source: Oral Oncology, Volume 86

Author(s): Mijin Kim, Hee Kyung Kim, Hye In Kim, Eun Heui Kim, Min Ji Jeon, Hyon-Seung Yi, Eun Sook Kim, Hosu Kim, Tae Hyuk Kim, Bo Hyun Kim, Tae Yong Kim, Ho-Cheol Kang, Won Bae Kim, Jae Hoon Chung, Young Kee Shong, Sun Wook Kim, Won Gu Kim

Abstract

Objectives

Based on the tumor-node-metastasis staging system, eighth edition (TNM-8), N1b is no longer used as a variable to determine final stage in papillary thyroid carcinoma (PTC). We aimed to evaluate the predictability of a simple modification of the TNM staging with N1b classification in a large multicenter thyroid cancer cohort.

Materials and methods

This study included 7717 patients with PTC who underwent thyroid surgery between 1996 and 2005 from six tertiary hospitals. We classified patients with stage II into stage IIA and IIB with modified-TNM: older patients with N1b disease were classified as stage IIB, while remaining patients were classified as stage IIA.

Results

The mean age was 46.2 years, and 24% were aged ≥55 years. In older patients, the 10-year disease-specific survival (DSS) rate of N1b disease (86.3%) was approximately 10% lower than that of N1a disease, and patients with N1b had significantly poorer DSS than those with N1a (HR = 3.3, p < 0.001). When the modified-TNM was applied, DSS curves between stage groups significantly differed (p < 0.001), and the relative risk of DSS in stage IIB patients was 2.3 times higher than in stage IIA patients (p < 0.001). The proportion of variation explained value of the modified-TNM was 4.9% and that of the TNM-8 was 4.7%.

Conclusion

This multicenter study reveals that the presence of lateral lymph node metastasis affects disease mortality in PTC, especially in older patients. The sub-classification of stage II in older patients improves DSS predictability. This simple modification of TNM-8 provides better prognostic information for patients with PTC.

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A Very Rare Complication of Hepatitis A Infection: Acute Myocarditis—A Case Report with Literature Review

Hepatitis A is a common viral infection with a benign course but in rare cases can progress to acute liver failure. It usually presents with abdominal pain, nausea, vomiting, diarrhea, jaundice, anorexia, or asymptomatically, but it can also present atypically with relapsing hepatitis and prolonged cholestasis. In addition, extrahepatic manifestations have been reported, including urticarial and maculopapular rash, acute kidney injury, autoimmune hemolytic anemia, aplastic anemia, acute pancreatitis, mononeuritis, reactive arthritis, glomerulonephritis, cryoglobulinemia, Guillain–Barre syndrome, and pleural or pericardial effusion. A rare manifestation of hepatitis A is acute myocarditis. We report a case of a young woman who presented with "flu-like symptoms" and was found to have severe elevation of liver enzymes due to acute hepatitis A infection. On her 3rd day of admission, the patient developed chest pain and nonspecific electrocardiographic changes. Her troponins rose to 16.4  ng/mL, and a transthoracic echocardiogram revealed global hypokinesis and a depressed ejection fraction at 30%. A CT angiography showed no evidence of significant coronary artery disease. The patient was managed supportively, and symptoms and laboratory findings slowly improved over the next 7 days. Her chest pain resolved and a follow-up echocardiogram showed improved ejection fraction to 45%.

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The Telomerase and Alternative Lengthening of Telomeres Mechanisms Regulate Laryngeal Cancer Cell Apoptosis via the PI3K/Akt Pathway

Purpose: To investigate the possible telomerase and alternative lengthening of telomeres (ALT) mechanisms influencing the apoptosis of laryngeal squamous cells. Materials and Methods: The effects of the telomerase mechanism were observed by knockdown of human telomerase reverse transcriptase (hTERT). The ALT mechanism was induced by silencing related genes including TRF2, RAD51, and NBS1. Effects of telomerase and ALT mechanisms on tumor development were confirmed by xenograft tumors model. Tumor cell apoptosis was investigated by flow cytometry and Hoechst staining. Caspase-3 activity assay and Western blot were performed to investigate the possible mechanisms. Results: After silencing ALT- and telomerase mechanism-related genes, Bax and Bcl-2 were increased, and nuclear factor (NF)-κB translocation and PI3K/Akt phosphorylation were inhibited. Conclusions: The inhibition of telomere-related genes inhibited the growth of laryngeal squamous cell carcinoma by promoting cell apoptosis via the PI3K/Akt pathway.
ORL

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Aflatoxin M 1 in cow, sheep, and donkey milk produced in Sicily, Southern Italy

Abstract

Samples (n = 485) of raw (n = 394) or heat-treated (n = 91) milk of three different species (cow, n = 170; sheep, n = 133; donkey, n = 84), collected 2013–2016 in Western Sicily (Southern Italy), were analyzed for aflatoxin M₁ (AFM₁) by enzyme-linked immunosorbent assay (ELISA). Positive ELISA results were further analyzed by HPLC with fluorescence detection. Both methods had a detection limit for AFM₁ in milk of 7 ng kg⁻¹. ELISA yielded 12.9 and 5% positives in cows and sheep milk, respectively, all samples of donkey milk were negative. Levels of AFM₁ were in most cases at 0.007–< 0.05 μg kg⁻¹, only two samples (sheep milk) slightly exceeded the European Union maximum level of 0.05 μg kg⁻¹. Only 6% of the samples were positive for AFM₁ in a concentration range of 0.008–0.15 μg kg⁻¹. Only milk samples collected directly from farms were positive. Overall, the levels were much lower than previously reported for Southern Italy cow and sheep milk samples purchased in retail stores. The results of this work indicate a continuous improvement of the feeding techniques on dairy farms of Southern Italy, which is essential to ensure consumers' protection.

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Versorgungsforschung in der Dermatologie 2018 – Kraft des Faktischen

Zusammenfassung

In der in Deutschland praktizierten Dermatologie ist Versorgungsforschung eine etablierte und hoch differenzierte Disziplin. In vielen universitären dermatologischen Einrichtungen und niedergelassenen Praxen werden Studien zu Vorgängen der gesundheitlichen Versorgung bei Hautkrankheiten durchgeführt. Unter dem Dach der Deutschen Dermatologischen Gesellschaft und des Berufsverbandes der Deutschen Dermatologen wird ein wesentlicher Teil der Studien und Projekte des Competenzzentrums Versorgungsforschung in der Dermatologie (CVderm) als bundesweites Referenzzentrum getragen. Wichtige Projekte sind Implementierung von Patientenregistern, Umsetzung nationaler Versorgungsstudien, Forschung mit Sekundärdaten sowie Durchführung methodischer Studien zur Weiterentwicklung wissenschaftlicher Fragestellungen. Wichtige Ergebnisse sind die nationalen Versorgungskonferenzen für Psoriasis, Hautkrebs, Wunden und Neurodermitis, die regionalen Versorgungsnetze sowie Projekte und Kooperationen mit Krankenkassen, Selbstverwaltung und öffentlichen Trägern. Im Interesse der verbesserten Patientenversorgung werden wichtige Faktoren der Versorgung laufend verbessert. Zukünftige dermatologische Versorgungsforschung wird in noch effizienterer Weise zur besseren Versorgungsplanung und -lenkung beitragen. Patientenregister werden den Transfer von Innovationen in die Versorgung erleichtern und dazu beitragen, dass neue Therapieverfahren angewendet werden können. Register unterstützen auch die Optimierung der Therapieansätze, die inzwischen beispielsweise bei Psoriasis wegen der Fülle an zur Verfügung stehenden Arzneimitteln nicht mehr allein auf der Basis klinischer Studien durchgeführt werden kann. Im Zeitalter der digitalen Medizin kommt der Versorgungsforschung eine noch wichtigere Funktion zu.

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„Schuppenflechte“ oder „Psoriasis“?

https://ift.tt/2p3AAV3

Biologic Therapy as a First-Line Treatment in Patients with Psoriasis: An Unstudied Population

O. Baniandrés Rodríguez
Actas Dermosifiliogr 2018;109:579

Full Text - PDF

https://ift.tt/2NErc8d

Allergic Contact Dermatitis Due to Paraphenylenediamine: An Update

B. Encabo Durán, D. Romero-Pérez, J.F. Silvestre Salvador
Actas Dermosifiliogr 2018;109:602-9

Abstract - Full Text - PDF

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The First Year of the AEVD Primary Cutaneous Lymphoma Registry

Y. Peñate, O. Servitje, S. Machan, R. Fernández-de-Misa, M.T. Estrach, E. Acebo, J. Mitxelena, M.D. Ramón, A. Flórez, M. Blanes, M. Morillo, S. Medina, J. Bassas, A. Zayas, P. Espinosa, A. Pérez, N. Gónzalez-Romero, J.D. Domínguez, C. Muniesa, J. López Robles, A. Combalia, I. Yanguas, H. Suh, I. Polo-Rodríguez, I. Bielsa, A. Mateu, B. Ferrer, M.A. Descalzo, I. García-Doval, P.L. Ortiz-Romero
Actas Dermosifiliogr 2018;109:610-6

Abstract - Full Text - PDF

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Description of Patients Treated with Biologic Drugs as First-Line Systemic Therapy in the BIOBADADERM Registry Between 2008 and 2016

G. Carretero Hernández, C. Ferrándiz, R. Rivera Díaz, E. Daudén Tello, P. de la Cueva-Dobao, F.J. Gómez-García, E. Herrera-Ceballos, I. Belinchón Romero, J.L. López-Estebaranz, M. Alsina Gibert, J.L. Sánchez-Carazo, M. Ferrán Farrés, A. González Quesada, J.M. Carrascosa Carrillo, M. Llamas-Velasco, M.V. Mendiola Fernández, D. Ruiz Genao, C. Muñoz Santos, I. García-Doval, M.A. Descalzo
Actas Dermosifiliogr 2018;109:617-23

Abstract - Full Text - PDF

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Practice Models in Teledermatology in Spain: Longitudinal Study, 2009-2014

G. Romero, D. de Argila, L. Ferrandiz, M.P. Sánchez, S. Vañó, R. Taberner, P. Pasquali, C. de la Torre, F. Alfageme, J. Malvehy, D. Moreno-Ramírez
Actas Dermosifiliogr 2018;109:624-30

Abstract - Full Text - PDF

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Management of Moderate to Severe Psoriasis in Routine Clinical Practice in Spanish Hospitals

J.L. López-Estebaranz, P. de la Cueva-Dobao, C. de la Torre Fraga, M. Galán Gutiérrez, E. González Guerra, J. Mollet Sánchez, I. Belinchón Romero
Actas Dermosifiliogr 2018;109:631-42

Abstract - Full Text - PDF

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Idiopathic Facial Aseptic Granuloma: Clinical and Ultrasound Findings in 3 Cases

A.I. Rodríguez-Bandera, M. Feito-Rodríguez, R. Maseda-Pedrero, R. de Lucas-Laguna
Actas Dermosifiliogr 2018;109:e1-5

Abstract - Full Text - PDF

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Pityriasis Lichenoides et Varioliformis Acuta Associated With Human Herpesvirus 7

M. Costa-Silva, A. Calistru, J. Sobrinho-Simões, C. Lisboa, F. Azevedo
Actas Dermosifiliogr 2018;109:e6-e10

Abstract - Full Text - PDF

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Máculas evanescentes en tronco y extremidades

M.Á. Flores-Terry, M. Franco-Muñóz, J.A. Garrido-Martín, N. Villasanti-Rivas
Actas Dermosifiliogr 2018;109:645-6

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Tumor Collision Over Sebaceous Nevus: Clues for Dermoscopic Diagnosis

A. Lobato-Berezo, P. Aguilera-Peiró, R.M. Pujol
Actas Dermosifiliogr 2018;109:647-8

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Quality of Life in Nonmelanoma Skin Cancer

P. García-Montero, M.V. de Gálvez-Aranda, M. de Troya Martín
Actas Dermosifiliogr 2018;109:649-50

Full Text - PDF

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Cervical Cellulitis of Odontogenic Origin

P. García-Montero, G. González-Pérez, N. Blázquez-Sánchez
Actas Dermosifiliogr 2018;109:652

Full Text - PDF

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Agminated Dermal Melanocytosis in the Territory of Ota's Nevus

L. Diluvio, M. Mazzeo, L. Bianchi, E. Campione
Actas Dermosifiliogr 2018;109:653-5

Full Text - PDF

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Enfermedad de Rosai-Dorfman cutánea: una nueva presentación clínica

J.M. Conde, A.Y. Kim, R. de Miguel, C.H. Nousari
Actas Dermosifiliogr 2018;109:655-7

Full Text - PDF

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Transoral robotic surgery versus upper airway stimulation in select obstructive sleep apnea patients

The Laryngoscope, EarlyView.


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Narrow Band Imaging Endoscopy of the Nasopharynx for Malignancy: An Inter‐ and Intraobserver Study

The Laryngoscope, EarlyView.


https://ift.tt/2Ms5506

Facial Palsy‐Specific Quality of Life in 920 Patients: Correlation With Clinician‐Graded Severity and Predicting Factors

The Laryngoscope, EarlyView.


https://ift.tt/2NGg7Uh

Longitudinal Pure‐Tone Threshold Changes in the Same Subjects: Analysis of Factors Affecting Hearing

The Laryngoscope, EarlyView.


https://ift.tt/2Msr8Ur

Anatomical Course of the Thyroarytenoid Branch of the Recurrent Laryngeal Nerve

The Laryngoscope, EarlyView.


https://ift.tt/2NCbFGc

Laser Soldering of Cartilage Graft Interposed Into a Tracheal Incision in a Porcine Model

The Laryngoscope, EarlyView.


https://ift.tt/2NDM3Zn

Radiation and Second Primary Thyroid Cancer Following Index Head and Neck Cancer

The Laryngoscope, EarlyView.


https://ift.tt/2MtUpOC

The Otolaryngology Match: A Bibliometric Analysis of 222 First‐Year Residents

The Laryngoscope, EarlyView.


https://ift.tt/2NH86yr

Does Medical Therapy Improve SinoNasal Outcomes Test–22 Domain Scores? An Analysis of Clinically Important Differences

The Laryngoscope, EarlyView.


https://ift.tt/2Msr6vN

What Is the Utility of Fine‐Needle Aspiration in Parotid Gland Neoplasms?

The Laryngoscope, EarlyView.


https://ift.tt/2MwlNvG

Development of a survival animal model for subglottic stenosis

The Laryngoscope, EarlyView.


https://ift.tt/2NKHY60

Endoscopic Resection Followed by Proton Therapy With Pencil Beam Scanning for Skull Base Tumors

The Laryngoscope, EarlyView.


https://ift.tt/2MqeLZ6

Comparing Upper Airway Stimulation to Transoral Robotic Base of Tongue Resection for Treatment of Obstructive Sleep Apnea

The Laryngoscope, EarlyView.


https://ift.tt/2NKHXyY

Granulomas of the membranous vocal fold after intubation and other airway instrumentation

The Laryngoscope, EarlyView.


https://ift.tt/2MqeNjG

Does Delaying Endoscopic Sinus Surgery Adversely Impact Quality‐of‐Life Outcomes?

The Laryngoscope, EarlyView.


https://ift.tt/2NCRLL8

Histone Variants as Stem Cell Biomarkers for Long‐Term Injection Medialization Laryngoplasty

The Laryngoscope, EarlyView.


https://ift.tt/2MqeN3a

Sudden hearing loss after cialis (tadalafil) use: A unique case of cochlear hydrops

The Laryngoscope, EarlyView.


https://ift.tt/2NCRCay

Endoscopic Posterior Cricoid Split With Graft in an Adult With Posterior Cricoid Fracture

The Laryngoscope, EarlyView.


https://ift.tt/2MtUlym

Nichtkleinzelliges Lungenkarzinom – Pathologie und Biologie

Zusammenfassung

Hintergrund

Nichtkleinzellige Lungenkarzinome (NSCLC) machen ca. 75 % der malignen epithelialen Lungentumoren aus. In den vergangenen Jahren konnten profunde Erkenntnisse über molekulare Mechanismen der Krebsentstehung der Lunge gewonnen werden und in der Folge zielgerichtete Substanzen („targeted drugs") und immuntherapeutisch wirksame Medikamente entwickelt werden. Diese Fortschritte haben den Ablauf der pathologischen Diagnostik maßgeblich beeinflusst.

Ziel

Der vorliegende Artikel soll einen Überblick über die häufigsten histologischen Subtypen der NSCLC, ihre morphologischen, immunhistochemischen und molekularpathologischen Charakteristika geben.

Material und Methoden

Eine selektive Literaturrecherche der Datenbank Pubmed wurde durchgeführt.

Ergebnisse und Diskussion

Adenokarzinome, Plattenepithelkarzinome und großzellige Karzinome sind die häufigsten histologischen Subtypen. Durch die in der pathologischen Routine verfügbaren Zusatzuntersuchungen lassen sich in der Regel auch gering differenzierte Tumoren gut zuordnen. NSCLC zeigen eine Reihe genetischer Veränderungen, therapeutisch nutzbar sind Alterationen von EGFR, MET, ALK1 und ROS1.

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Langerhans cells express human β‐defensin 3: relevance for immunity during skin ageing

British Journal of Dermatology, EarlyView.


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Variation in daily ultraviolet light exposure and sun protection behaviours of melanoma survivors: an observational single‐arm pilot study with a wearable sensor

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


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GM‐CSF as a therapeutic target in psoriasis: randomised, controlled investigation using namilumab – a specific, human anti‐GM‐CSF monoclonal antibody

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2x5Bogu

Impact of Helicobacter pylori and/or Helicobacter pylori‐related metabolic syndrome on gastroesophageal reflux disease‐ Barrett's esophagus‐ esophageal adenocarcinoma sequence

Helicobacter, EarlyView.


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