Toward a sensible single antigen bead cut-off based on kidney graft survival

Background There is no consensus in the literature on the interpretation of single antigen bead (SAB) positive for a specific HLA antibody. Methods To inform the debate, we studied the relationship between various SAB positivity algorithms and the impact of resulting donor-specific HLA antibody (DSA) positivity on long-term kidney graft survival in 3237 deceased-donor transplants. Results First, we showed that the interassay variability can be greatly reduced when working with signal-to-background ratios instead of absolute MFIs. Next, we determined pretransplant DSA using various MFI cut-offs, signal-to-background ratios (STBR) and combinations thereof. The impact of the various cut-offs was studied by comparing the graft survival between the DSA-positive and DSA-negative groups. We did not observe a strong impact of various cut-off levels on 10-year graft survival. A stronger relationship between the cut-off level and 1-year graft survival for DSA-positive transplants was found when using STBR, most pronounced for the bead of the same HLA-locus with lowest MFI taken as background. Conclusions With respect to pretransplant risk stratification, we propose a SBTR-6 (using the bead of the same HLA-locus with lowest MFI as background) cut-off of 15 combined with an MFI cut-off of 500, resulting in 8% and 21% lower 1- and 10-years graft survival, respectively, for 8% DSA positive transplants. Corresponding author: E-mail address: H.G.Otten@umcutrecht.nl. Corresponding author permanent address: Laboratory of Translational Immunology, University Medical Center Utrecht, F.03.821, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. Tel.: +31 88 75 57680 Disclosure The authors of this manuscript have no conflicts of interest to disclose. Authorship Participated in research design: BW, EK, AD, LP, HO Participated in writing of the paper: BW, EK, IJ, WA, LH, AvZ, MV, MLB, BH, AL, LB, CR, CV, ItB, AH, SH, DR, FC, HO Participated in the performance of the research: BW, EK, AD, LP Contributed new reagents or analytic tools: BW, EK, IJ, WA, AvdM, LH, MCB, ES, CH, FvR, AvZ, MV, MLB, AD, LP, MS, JS, BH, AL, LB, CR, MT, CV, LW, EvD, MG, MC, FvI, AN, NL, WS, KvdP, NvdW, ItB, FB, AH, PvdB, JdF, MB, SH, DR, FC, HO Participated in data analysis: BW, EK, HO Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2P7LDbI

Comparison of long-pulsed Nd: YAG laser with cryotherapy in treatment of acral warts

Abstract

Acral warts are considered as prevalent reasons for dermatologic consultations and remain an important continuing challenge until now because there is no consensus about optimal therapeutic modality. This study investigated the efficacy of long-pulsed Nd: YAG laser therapy and cryotherapy in treatment of acral warts. Patients who underwent treatment with cryotherapy or long-pulsed Nd: YAG laser therapy for symmetrical and bilateral warts on the extremities (hand and foot) that is confirmed by an expert dermatologist from May 2016 until March 2018 were assessed for enrollment in our study. Laser and cryotherapy sessions were applied every 2 weeks for a maximum of six sessions. Patients followed up and evaluated 3 months after the last treatment. Data were analyzed by SPSS (v.21. IBM Inc. IL). The P value less than 0.05 was considered significant. From 60 enrolled patients, 134 lesions were treated using cryotherapy and 114 other lesions treated with laser beam. Thirty-four males (average age 26.85 ± 7.528 years) and 26 females (average age 26.73 ± 5.640 years) participated. Finally, it was a significant reduction in both lesion width (P = 0.000) and length (P = 0.000) after the sessions of cryotherapy. The width and length of lesions is reduced significantly after each session of laser therapy similarly (P = 0.000). Cryotherapy and long-pulsed Nd: YAG laser are effective on the reduction of both width and length of lesions. Clinically, the methods are not different in their ultimate effects.

https://ift.tt/2MkNHyH

The Metabolic Syndrome and Health Behaviors in School Children Aged 13–16 Years in Ubon Ratchathani: UMeSIA Project

Metabolic Syndrome and Related Disorders, Ahead of Print.


https://ift.tt/2KPWYtG

Association of Thyroid Function and Autoimmunity with Ovarian Reserve in Women Seeking Infertility Care

Thyroid, Ahead of Print.


https://ift.tt/2MMEpIE

Surgical Confirmation of Incomplete Treatment for Primary Papillary Thyroid Carcinoma by Percutaneous Thermal Ablation: A Retrospective Case Review and Literature Review

Thyroid, Ahead of Print.


https://ift.tt/2MogmTq

Low Iodine Intake from Dairy Foods Despite High Milk Iodine Content in Israel

Thyroid, Volume 28, Issue 8, Page 1042-1051, August 2018.


https://ift.tt/2MNBbEA

Photocarcinogenic risks of narrowband ultraviolet B therapy and psoralen + ultraviolet A therapy

Introduction: Narrowband UVB Therapy and Psoralen + UVA therapy are widely used in the treatment of several skin disorders. Although short-term security has been demonstrated, there are several concerns about long term security and, in particular, the risk of skin cancer after NB-UVB and PUVA therapy.

https://ift.tt/2nKWJqR

Morgellons disease: A review of a mysterious psychodermatologic disorder

Introduction: Morgellons disease is a rare, unexplained skin disorder that whose specific etiology remains a mystery to both the Dermatologic and Psychiatric community as the specific etiology remains unknown. The condition is characterized by the physical presentation of painful sores with reported crawling sensations within the skin and the fixed belief of infection or parasitic infestation. The pathognomonic feature of this disease is the presence of filaments or fibers embedded in and emerging from these sores.

https://ift.tt/2MK5Xyo

Effectiveness of the Eczema Action Plan (EAP) in improving the Eczema Area and Severity Index (EASI) scores among pediatric patients with atopic dermatitis: A pragmatic randomized controlled trial

Introduction: Atopic dermatitis (AD) is a chronically relapsing skin disease that occurs most commonly during early infancy and childhood. Education about the condition is vital in helping patients and their caregivers understand the nature of the disease. Evidence show that adherence is poor. There are no reported studies on interventions done so far to increase treatment adherence among patients with atopic dermatitis in the local setting. This study aims to improve treatment adherence among patients with atopic dermatitis through improvement of the EASI scores.

https://ift.tt/2MjA03C

Mania induced by narrowband ultraviolet B phototherapy treatment

Phototherapy has been used for decades in the treatment of many common dermatologic conditions, such as psoriasis, atopic dermatitis, cutaneous T-cell lymphoma, vitiligo, and scleroderma, among others. Before the commencement of phototherapy, many factors must be considered. For dermatologists, the most important factors include the determination of a patient's skin phototype, concurrent use of photosensitizing agents, and calculation of minimal erythema dose (MED). Though infrequent, the side-effects to phototherapy commonly discussed with patients include burns, ocular toxicity, polymorphous light eruption, potential for skin carcinogenesis, and possible worsening of the skin disease.

https://ift.tt/2w7iCnY

Hemorrhagic vesiculobullous erythema migrans: An atypical presentation of Lyme disease

Background: Erythema migrans (EM) is the most well known cutaneous manifestation of Lyme disease. Review of the literature and the case described below suggest that atypical cutaneous presentations, such as vesiculobullous EM, can occur and must remain in the differential diagnosis in the proper clinical setting.

https://ift.tt/2MMr7Mg

Computer-based video instruction of dermatologic procedures for training medical students: A blinded randomized controlled trial

Purpose: Medical students receive 10-26 hours of dermatology education throughout their curriculum. Most procedural training is based largely on an apprenticeship model, which results in wide variability in the level of technical skills acquired during undergraduate medical training. No standardized methodology exists to teach dermatologic skills to preclinical medical students. The purpose of this study was to investigate the significance of computer-based video instruction (CBVI) to augment in-person simulation based instruction to train medical students in shave biopsy techniques.

https://ift.tt/2MeyTSO

Nevus simplex on the midline of the forehead

Background: Recently, studies reported medial frontofacial capillary malformation (CM) that appeared like nevus simplex (NS), but differed in that the lesion had a wider median topography and darker color, and faded more slowly or incompletely.

https://ift.tt/2MMqYZe

Insight into trombiculosis: Two case reports

Trombiculosis (also known as "tlazahuate" in Mexico) is an infestation of the skin by the larval stage of various species of mites (chiggers) belonging to the phylum Arthropoda, class Arachnida, subclass Acari, family Trombiculidae. Humans act as accidental hosts. Painless papules similar to molluscoid lesions caused by a hypersensitivity reaction to the mite's saliva can be found. We report the case of a 65-year-old woman and an 86-year-old man from Tizapan el Alto, Jalisco, who worked as farmers.

https://ift.tt/2MdybFr

Evaluation in real life of an adapted information impact for effective photoprotection: An example with patients with actinic keratosis

Introduction: Cutaneous actinic keratosis lesions preferentially affect people with clear skin and indicate an excess of solar exposure. Actinic keratosis can be esthetically troublesome and require a medical care with consultations at regular intervals to allow the dermatologist the detection of a possible development toward a skin cancer. Whatever the treatment chosen by the dermatologist, the medical care is always the opportunity to inform and educate people about the necessity of an effective photoprotection to avoid the risk of recurrence.

https://ift.tt/2MNf4OI

Demographic and health care service utilization by 4,417 patients with hidradenitis suppurativa

Background: Data on the health care utilization of hidradenitis suppurativa (HS) patients in primary care settings are scarce.

https://ift.tt/2nKWBHT

Primary signet ring cell/histiocytoid carcinoma of the eyelid

Background: Primary cutaneous signet ring cell/histiocytoid carcinoma is a rare, aggressive tumor that occurs most frequently on the eyelid.

https://ift.tt/2wb0CJ8

Out of the blue and into the black

Introduction: ANCA-associated vasculitides (AAV) are systemic vasculitides involving small to medium vessels and are divided into three separate clinical entities with many overlapping and some distinctive features. Here we present a case having features of all three AAV, including microscopic polyangiitis, granulomatosis with polyangiitis, and eosinophilic granulomatosis with polyangiitis.

https://ift.tt/2nDyf2D

Levocarnitine for vismodegib-associated muscle spasms: A pilot randomized, double-blind, placebo-controlled, investigator-initiated trial

Background: Smoothened inhibitors (SIs) are a new targeted therapy approved by the United States Food and Drug Administration (FDA) for the treatment of advanced basal cell carcinoma (BCC). However, no placebo-controlled studies exist on management of their most common side-effect, muscle spasms, which affect up to 80% of patients taking SIs and are the most common reason for drug discontinuation despite tumor response. Based on anecdotal observations of exercise exacerbating SI-associated spasms, and existing evidence that levocarnitine (LC) can reduce markers of exercise induced stress, we explored the effect of oral LC usage on muscle spasms occurring after initiation of vismodegib, an SI.

https://ift.tt/2MKllux

From relative to absolute treatment outcomes—Correlation of PASI 90 and PASI ≤2 in three clinical trials with secukinumab

Introduction: Relative improvement of psoriasis area and severity index (PASI) during treatment compared with baseline PASI is the current standard definition of response in trials and practice. A ≥75% improvement in PASI (PASI 75) is the current treatment goal in international guidelines. With the advent of more effective biologic treatments, an improvement by ≥90% (PASI 90) is under consideration as a new treatment goal. As an alternative for long-term management, baseline-independent absolute PASI treatment goals are being discussed.

https://ift.tt/2MQUYDq

Elephantiasic pretibial myxedema, chronic and recalcitrant thyroid dermopathy

Patients afflicted with autoimmune thyroiditis, specifically Graves disease, can have extrathyroidal manifestations such as exophthalmos, thyroid dermopathy, and acropachy. Thyroid dermopathy usually presents as pretibial myxedema (PTM) due to its predilection for the pretibial area. In severe forms of PTM, it can present as the elephantiasic form, which is notoriously resistant to conventional treatment. Due to the disease rarity, only a few case reports of elephantiasic PTM exist in the literature.

https://ift.tt/2nKWn3v

Correlation of d-dimers to response to treatment in chronic spontaneous urticaria (UAS7 score): Results from the SUNRISE study

Objectives: Increased levels of blood d-dimers (D-D), the by-products of fibrin degradation, are linked to the severity of chronic spontaneous urticaria (CSU) and to poor response to antihistamines H1 (AH1). Omalizumab (OMA) is a human monoclonal anti–immunoglobulin E antibody registered as an add-on treatment of CSU in adults and adolescents (≥12 years old) with insufficient response to AH1. The SUNRISE study assessed the efficacy of Omalizumab on CSU symptoms and the correlation between D-D levels and response over time to treatment with OMA to explore its potential predictive value.

https://ift.tt/2w6oYUt

Cutaneous lymphangitic carcinomatosis associated with parotid gland duct carcinoma: An unreported case

Introduction: Salivary duct carcinoma of parotid gland is an uncommon neoplasm exceptionally associated with cutaneous metastasis. We described an unreported association of cutaneous lymphangitic carcinomatosis from parotid gland duct carcinoma in a 67-year-old woman.

https://ift.tt/2nGe6ZI

Clinical characteristics and outcomes of patients with superficial venous thrombosis at multiple sites simultaneously

Background: Superficial venous thrombosis (SVT) results from thrombus formation within a superficial vein that is associated with inflammation of the surrounding tissue, and classically presents with pain, tenderness, induration, and/or erythema in the form of a palpable cord. Although traditionally considered a local, benign disorder, recent studies demonstrate that patients with SVT are at significant risk for deep vein thrombosis (DVT), pulmonary embolism (PE), and other venous thromboembolic (VTE) events.

https://ift.tt/2MLGGDY

Porokeratosis ptychotropica: A differential diagnosis for “psoriasis” of the gluteal region

A 51-year-old man presented with an 8-year history of a well demarcated erythematous scaly plaque on the buttocks, extending into the natal cleft. Initial skin biopsy was reported as showing features of psoriasis. Treatment with topical calcipotriol, acitretin, UVB and intralesional triamcinolone were ineffective. Repeat biopsies taken from two different areas showed neutrophilic collections within the stratum corneum and a psoriasiform pattern of hyperplasia supporting the initial diagnosis of psoriasis.

https://ift.tt/2nFVPfe

Extensive abdominal wall ulceration as a late manifestation of antiphospholipid syndrome: a case report

Antiphospholipid syndrome is an autoimmune disorder characterized by the presence of antiphospholipid antibodies and commonly presents with vascular thromboembolic phenomena, thrombocytopenia, and obstetric co...

https://ift.tt/2nADEHA

Unilateral pulmonary edema: a case report and review of the literature

Unilateral pulmonary edema is an uncommon condition and is a rare clinical entity that is often misdiagnosed at the initial stages. In a majority of patients it occurs in the upper lobe of the right lung. Ther...

https://ift.tt/2KOeRZT

Aflatoxin M 1 levels in different marketed milk products in Nairobi, Kenya

Abstract

Milk is an important source of energy and nutrients, especially for children, and in Kenya, milk consumption is higher than other countries in the region. One major concern with milk is the risks of chemical contaminants, and reports of high levels of aflatoxin M₁ (AFM₁) in milk in Kenya has been causing public health concerns. This study collected marketed milk products every month during 1 year, just as a consumer would purchase them from retailers and traders in a low-income area, and a major supermarket in a middle/high-income area. In total, 291 sampled milk products (raw, pasteurised, UHT milk, yoghurt and lala) were collected and analysed for AFM₁ using a commercial ELISA kit. More than 50% of the samples exceeded 50 ng/kg (the level allowed in the EU), but only three samples exceeded 500 ng/kg (the level allowed in the USA). Geometric mean AFM₁ level was 61.9 ng/kg in the 135 samples from the low-income area while it was 36.1 ng/kg in the 156 from the higher income area (p < 0.001). The levels varied significantly depending on the time of year, with lowest levels of milk in January. There were also differences between manufacturers and products, with UHT milk having lower levels. There was no difference depending on the price for all dairy products, but when only including milk, higher price was associated with lower levels of AFM₁. In conclusion, this study shows that milk purchased by a consumer is likely to contain AFM₁ above 50 ng/kg, and that further research is needed to find ways to mitigate AFM₁ contamination through working with farmers and milk processors both in the formal and informal sectors.

https://ift.tt/2Pb3wGM

Clinical Thyroidology®for the Public – Highlighted Article

From Clinical Thyroidology^® for the Public: Thyroid hormone is necessary for development and growth of brain in developing babies during pregnancy. Studies have shown that hypothyroidism and low thyroid hormone levels without hypothyroidism may be associated with some developmental problems in children. Read More…

We welcome your feedback and suggestions. Let us know what you want to see in this publication.

Feedback & Suggestions

The post Clinical Thyroidology^®for the Public – Highlighted Article appeared first on American Thyroid Association.

https://ift.tt/2OE0UQB

Transurethral thulium laser enucleation versus resection of the prostate for treating benign prostatic hyperplasia: a retrospective study

Abstract

This study aimed to compare the clinical outcomes between transurethral thulium laser enucleation of the prostate (ThuLEP) and transurethral thulium laser resection of the prostate (ThuLRP) for treating benign prostatic hyperplasia (BPH). From May 2014 to August 2015, 212 patients underwent ThuLRP and 188 patients underwent ThuLEP. The ThuLEP group was further divided into two subgroups according to the ways the prostate was taken out. The perioperative parameters were recorded and analyzed. The international prostate symptom score (IPSS), quality-of-life (QoL) score, maximum flow rate (Qmax), and postvoid residual urine volume (PVR) in both groups were estimated and compared 3, 6, and 12 months after surgery. No significant difference was observed between the groups in terms of irrigated time, irrigated volume, catheterization time, and hospital stay. However, the significantly lower hemoglobin drop was observed in the ThuLRP group compared with the ThuLEP group. The ThuLEP group with a morcellator required a shorter operation time for patients with large prostate volume (> 60 mL) compared with the ThuLRP and ThuLEP groups without a morcellator. During 12 months of follow-up, IPSS, Qmax, QoL, and PVR improved significantly without significant differences between the groups. No severe complications were reported; however, the occurrence of transient urge incontinence was higher after ThuLEP compared with ThuLRP, and the proportion of urinary tract infection after surgery was higher in ThuLRP than in ThuLEP. ThuLRP and ThuLEP are safe and efficient for treating patients with symptomatic BPH. ThuLRP offers advantages in terms of minimal blood loss.

https://ift.tt/2Oz7mIs

Effects of the extracorporeal shock wave therapy on the skin: an experimental study

Abstract

Extracorporeal shock wave therapy (ESWT) has been extensively studied for its multiple biological properties, and although it is widely applied in esthetical procedures, little is known about its effects on the epidermis and dermis. In this study, a histological and immunohistochemical study of the effects of ESWT was performed on rat skin. Forty-five female rats were treated with one or two sessions of ESWT and sacrificed on days 1, 7, 14, and 21 after treatment. The samples were histologically processed and then morphometric analyses were performed to assess the epidermis, dermis, and subcutaneous fat tissue thickness. Immunohistochemical reactions were also performed against the antibodies: basic fibroblastic growth factor (FGF2), its receptor (FGFR1), and α-smooth muscle actin. Slides were scanned and digitally assessed, to determine the microvessel density (MVD) and digital scoring of the immunohistochemical staining. The results showed that ESWT produced a significantly higher collagen content, MVD, and epidermis and dermis thickness than the control, non-treated group. Both in epidermis and dermis, FGF2 was overexpressed in the ESWT-treated groups, whereas FGFR1 was increased only in the group treated with two ESWT sessions at 21-days post-treatment. The ESWT-treated groups have also shown diminished thickness of subcutaneous fat tissue. In conclusion, ESWT induces neocollagenesis and neoangiogenesis, and upregulates the FGF2 expression, particularly in the groups treated with two sessions. Furthermore, it was demonstrated that overexpression of FGF2 on skins treated with ESWT seems to be a key role on its mechanism of action.

https://ift.tt/2nG4q1s

Slow, slurred speech as an initial complaint in amyotrophic lateral sclerosis

Otorhinolaryngologic examinations at an early stage, particularly those conducted by vocal specialists, can make potentially important contributions to the diagnosis of bulbar-onset ALS patients.

https://ift.tt/2BdtoP6

Kimishige Ishizaka (1925–2018)

Publication date: Available online 14 August 2018

Source: Allergology International

Author(s): Hirohisa Saito

https://ift.tt/2P6vwvb

Risk-reductive dental strategies for medication related osteonecrosis of the jaw among cancer patients: A systematic review with meta-analyses

Publication date: October 2018

Source: Oral Oncology, Volume 85

Author(s): Harry Karna, Jaime Gonzalez, Harveen S. Radia, Parish P. Sedghizadeh, Reyes Enciso

Abstract

The purpose of this systematic review with meta-analysis was to assess the effectiveness of dental interventions in preventing or reducing the incidence of medication-related osteonecrosis of the jaw (MRONJ) in cancer patients receiving antiresorptive therapy, compared to similar control groups receiving no intervention. Randomized controlled trials (RCT), case-controls and cohorts on cancer patients with primary outcome being the prevalence of MRONJ were included. Four electronic databases were searched (Cochrane Library, PubMed, EMBASE and Web of Science) up to February 12, 2018. A total of 409 abstracts were assessed and one case-control, one RCT and four cohort studies with 2332 cancer patients met our inclusion criteria. Risk of bias analysis followed Cochrane's handbook. Risk of bias was unclear for the case-control study and high risk for the RCT and all cohort studies. Five studies utilized preventive measures consisting of an initial examination and performing all necessary dental treatment before patients initiated antiresorptive therapy; one study used specialized post-extraction protocols utilizing plasma-rich in growth factors (PRGF) on cancer patients receiving antiresorptive therapy. Though dental preventive measures decreased MRONJ incidence by 77.3% in six studies with 2332 cancer patients (95% CI = 47.4–90.2%; p = .001) compared to control groups, quality of the evidence was low due to high or unclear risk of bias and the observational nature of five of the included studies. In conclusion, high-quality long-term prospective large sample size studies are needed to confirm these results due to high risk of bias and heterogeneous interventions. No funding.

https://ift.tt/2vJ2sSh

Biphenotypic sinonasal sarcoma: demographics, clinicopathological characteristics, molecular features, and prognosis of a recently described entity

Abstract

Biphenotypic sinonasal sarcoma (BSNS) is a recently recognized type of sarcoma arising exclusively in the sinonasal tract displaying unique clinical course, histopathology, and genetics. Due to its rarity, only case series and case reports are available. In order to provide an overview of the current understanding of this disease, we present a comprehensive review of the literature and present three previously unreported cases of BSNS. A total of 55 genetically characterized and 41 cases without molecular data were identified in the literature. Two-thirds of patients were female and the peak incidence was in the fifth decade. Fatal outcome was rare (two cases with intracranial extension) and local recurrence occurred in 31.6%, all occurring within 5 years after initial treatment. Histologically, BSNS is highly cellular in the majority of cases and composed of fascicles of spindle cells, with entrapped hyperplastic surface epithelium being a frequent finding. The immunohistochemical profile is characteristic due to the biphasic nature of this lesion, with shared features of both myogenic and neural origin. Rhabdomyoblastic differentiation is apparent in a subset of cases. The most common genetic event is the PAX3-MAML3 fusion (58.6%) but isolated PAX3 rearrangement (19.2%), absence of rearrangements (9.1%), PAX3-FOXO1 (8.1%), PAX3-NCOA1 (4%), and isolated MAML3 rearrangement (2%) have also been reported. In conclusion, the recognition of BSNS is crucial due to its relatively indolent clinical course. A selected immunohistochemical panel and/or molecular confirmation can be used to aid in appropriate diagnosis and consequently in prognostication and to avoid overtreatment with chemotherapy regimens used in its mimics.

https://ift.tt/2BhZDwu

Future Meetings

Thyroid, Volume 28, Issue 8, Page 1076-1077, August 2018.


https://ift.tt/2BaMHZl

Double unilateral, bilateral, and multiple mandibular fractures: an observational study

Abstract

Purpose

Double and multiple mandibular fractures are associated to high morbidity and functional damage. This study aimed to evaluate the characteristics and outcomes of double unilateral, bilateral, and multiple mandibular fractures.

Methods

A 7-year observational retrospective analysis was performed, and the injury-related data were collected from the medical records. Statistical analysis was performed using Fisher's exact test (p < 0.05).

Results

In this period, 283 patients showed mandibular fractures. Of them, 83 (29.7%) had double or multiple mandibular fractures and were included in the study. Double bilateral fractures were more prevalent than multiple or double unilateral. Multiple fractures presented significant association with the combination of load-bearing and load-sharing fixation protocols. Most cases (94.0%) applied at least one type of internal fixation system. However, there was a positive association between condylar fractures and non-surgical treatment (p < 0.01). Moreover, mandibular body fractures were associated with load-bearing fixation (p < 0.01). In 56 cases, no complications were observed (67.5%). Complications were divided into treatment failure (10.8%) and transitory or minor complications (21.7%). There was no statistical association between complications and fracture pattern, fracture-tooth relation, and treatment modality.

Conclusion

Double and multiple mandibular fractures represented almost one third of all mandibular fractures, and regardless to treatment protocol, there was no difference about complications. Moreover, although a considerable complication rate was found, most of them were minor or transitory.

https://ift.tt/2BaIvJb

Double unilateral, bilateral, and multiple mandibular fractures: an observational study

Abstract

Purpose

Double and multiple mandibular fractures are associated to high morbidity and functional damage. This study aimed to evaluate the characteristics and outcomes of double unilateral, bilateral, and multiple mandibular fractures.

Methods

A 7-year observational retrospective analysis was performed, and the injury-related data were collected from the medical records. Statistical analysis was performed using Fisher's exact test (p < 0.05).

Results

In this period, 283 patients showed mandibular fractures. Of them, 83 (29.7%) had double or multiple mandibular fractures and were included in the study. Double bilateral fractures were more prevalent than multiple or double unilateral. Multiple fractures presented significant association with the combination of load-bearing and load-sharing fixation protocols. Most cases (94.0%) applied at least one type of internal fixation system. However, there was a positive association between condylar fractures and non-surgical treatment (p < 0.01). Moreover, mandibular body fractures were associated with load-bearing fixation (p < 0.01). In 56 cases, no complications were observed (67.5%). Complications were divided into treatment failure (10.8%) and transitory or minor complications (21.7%). There was no statistical association between complications and fracture pattern, fracture-tooth relation, and treatment modality.

Conclusion

Double and multiple mandibular fractures represented almost one third of all mandibular fractures, and regardless to treatment protocol, there was no difference about complications. Moreover, although a considerable complication rate was found, most of them were minor or transitory.

https://ift.tt/2BaIvJb

Adenocarcinoma within a tailgut cyst

Description 

We present a case of a 53-year-old woman with painful defaecation and lower abdominal pain. Her medical history and laboratory testing were unremarkable. An abdominopelvic CT scan was performed. Axial non-enhanced CT image (figure 1) and postcontrast CT image (figure 2) revealed a well-defined, slightly lobular soft tissue density mass in the retrorectal/presacral space. It shows a thin peripheral calcification and internal enhancing components after administration of intravenous contrast material. These features suggest a rare developmental retrorectal lesion, with enteric cysts (tailgut cyst and cystic rectal duplication) being the more common. Differential diagnosis comprises lymphangioma, epidermoid cyst, dermoid cyst, endometrioma, rectal duplication cyst, anal gland cyst and anterior meningocoele.

Figure 1

Axial non-enhanced CT image showing a heterogeneous nodular mass of tissue density with a tiny peripheral calcification in the presacral space.

Figure 2

Axial and sagittal postcontrast...

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Gallbladder empyema complicating acute myeloid leukaemia in an adolescent boy

Gallbladder (GB) empyema is an uncommon complication in acute myeloid leukaemia (AML). Non-specific signs and symptoms and rarity of disease in AML make it difficult to diagnose early. We report a case of 13-year-old boy who had AML and developed GB empyema in the neutropaenic period. The patient was managed with antibiotics, ultrasound-guided tapping and interval cholecystectomy and recovered well. GB empyema is a life-threatening complication which should be kept as a possibility while evaluating patients with neutropaenia with pain abdomen localised to right hypochondrium as early diagnosis and treatment can lead to better outcomes.

https://ift.tt/2OEfJmj

Thyroid metastasis from rectal adenocarcinoma

The thyroid is a rare site for metastasis, occurring in 0.1% of colorectal cases. A 46-year-old man with rectal adenocarcinoma developed an enlarging anterior neck mass and increasing carcinoembryonic antigen 2 years after curative intent treatment. Imaging showed aggressive features with invasion of the larynx, trachea and oesophagus, suspicious for anaplastic thyroid carcinoma. The patient underwent tumour debulking with neck dissection and tracheostomy. Final histopathological review revealed metastatic adenocarcinoma from a colorectal primary. Despite chemotherapy, the patient eventually succumbed to disease progression and complications of his illness. This case demonstrates that recognising rare sites of metastasis may help clinicians effectively institute earlier intervention.

https://ift.tt/2MscFvV

Aneurysmal fibrous histiocytoma

Aneurysmal fibrous histiocytoma (AFH) is a type of fibrohistiocytic tumour. We present a case of a patient who presented with a skin papule on the thigh region. Histopathological examination following total excision of the lesion revealed an AFH. No sign of recurrence was present 6 months after surgery.

https://ift.tt/2OzVDJD

Prostatitis, a rare presentation of granulomatosis with polyangiitis, successfully treated with rituximab and prednisone

A previously healthy 21-year-old man presented with an 8-month history of weight loss, lethargy and dysuria unresponsive to empiric antibiotics and paraurethral drainage of a prostatic abscess. Urinalysis showed pyuria, but cultures failed to grow any organisms. Additionally, he developed new onset sensorineural hearing loss. CT of the chest showed two right-sided cavitary lesions. CT of the abdomen and pelvis demonstrated a prostatic abscess. A prostate biopsy demonstrated necrotising granulomatous prostatitis. A lung biopsy showed necrotising granulomatous inflammation. He was diagnosed with granulomatosis with polyangiitis (GPA). He was successfully treated with rituximab and prednisone. At 6-month follow-up, he continued to be in remission with resolution of his symptoms. This case demonstrates a rare presentation of prostatitis as the presenting symptom of GPA. As far as we know, this case is the first documented report of rituximab and prednisone as successful therapy for prostatitis secondary to GPA.

https://ift.tt/2MrNU2S

Epstein-Barr-positive classical Hodgkin lymphoma-associated haemophagocytic lymphohistocytiosis: a rare case

Haemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition, which is usually triggered by autoimmune disorders, viral infections and malignancy, like lymphomas. We present a 60-year-old Hispanic woman with a medical history of hypertension and systemic lupus erythematosus presenting with fever, generalised weakness and shortness of breath for 3 weeks. She was hypotensive on presentation, and a CT scan of abdomen/chest showed multiple irregular hepatic and splenic hypodense lesions. A liver biopsy revealed Classical Hodgkin lymphoma (cHL) with positive Epstein-Barr virus (EBV) staining that was later confirmed with high serum EBV DNA levels. Incidentally, a liver biopsy disclosed haemophagocytosis in some cells. HLH-associated cHL is an uncommon condition that can cause severe systemic symptoms acting as the perfect mimic of septic shock, deviating the clinical eye toward treating with antibiotics and not addressing in a timely manner the real aetiology of the patient's condition.

https://ift.tt/2OyUli0

Severe thromboembolic phenomenon in the setting of pseudoprogression of melanoma brain metastases in response to combination immunotherapy

Approximately half of patients with metastatic melanoma develop brain metastasis (MBM) in their disease course. However, patients with MBM were often excluded from early immunotherapy trials, and therefore, the role of immunotherapy in these patients is less clear. We review the case of a patient with widespread metastatic melanoma and symptomatic brain metastases at initial diagnosis. In this case, we have demonstrated that it is reasonable to pursue combination ipilimumab and nivolumab in borderline performance status patients with extensive brain metastases. Additionally, this case teaches us to be vigilant for severe autoimmune toxicities such as severe thrombotic events in the setting of pseudoprogression of brain metastases. We discuss this case in the context of the current melanoma literature.

https://ift.tt/2nDwiTP

Post-traumatic aortic pseudoaneurysm causing acquired pulmonary artery stenosis

Description 

A 43-year-old man with a diagnosis of severe pulmonary stenosis was referred to us for pulmonary valve balloon dilatation. We reviewed the case and found that the patient was complaining of progressively increasing dyspnoea over the past one year. He did not complain of chest pain, syncope, limb swelling or cyanosis. History was unremarkable except for a motorbike accident which he suffered 10 years back and sustained injuries over his face, chest and limbs. He made full functional recovery within 2 months after the accident and remained free from any symptoms for the next 9 years.

We reviewed his echocardiogram and found that he had dilated right atrium and right ventricle. Left-sided chambers and valves were normal. The pulmonary valve was normal. Instead, he had supravalvular pulmonary stenosis caused by compression of the pulmonary artery by an extrinsic mass (figures 1 and 2). CT...

https://ift.tt/2OAotJP

Penile fracture after priapism due to sildenafil ingestion: out of frying pan into the fire

Description  

A 36-year-old man presented to our department with complaints of swelling, pain and deformed penis for 2 days. He had a history of 100 mg sildenafil ingestion, following which he sustained a prolonged erection that persisted even after sexual intercourse. He tried vigorous masturbation to relieve it, but he failed. After this exercise, while he was sleeping, his child mistakenly fell over his erect penis, following which he developed sudden severe pain in his penis and lost tumescence. On examination, he had swelling and ecchymosis on the right posterolateral aspect of his penis (figure 1). There was no haematuria or blood at meatus. On the basis of history and physical examination, a diagnosis of penile fracture was made. Ultrasound revealed a tear in the lateral wall of the right corpora cavernosa with a large haematoma. The patient was taken for emergency exploration. Intraoperatively, a defect of approximately 1x1 cm was visualised...

https://ift.tt/2nDvVsp

Aphallia: do sociocultural issues affect treatment decisions?

Description 

Otherwise healthy 1-month-old male patient (documented 46,XY karyotype) was referred to the plastic surgery unit for assessment. Physical exam revealed absence of penis and urethra along with a well-formed scrotum and both normally descended testicles (figure 1). No characteristic facial phenotype was noted. Also, there were no abdominal wall hernias nor abnormalities of the anal canal. An echocardiogram, abdominal ultrasound and CT were performed to exclude other malformations. CT scan revealed a functional but hypoplastic right kidney and the presence of a vesicorectal fistula. The rest of the studies including a hormonal profile were within normal limits.

Figure 1

Picture showing the perineal region of the patient.

Surgical fistula closure and perineal urethrostomy placement were recommended as initial treatment. Also, the possibility of either early female sexual reassignment or phalloplasty were proposed as long-term options for definitive reconstruction. The...

https://ift.tt/2OA91gP

Bilateral primary adrenal lymphoma successfully treated with non-CHOP chemotherapy regimen

Primary bilateral non-Hodgkin's lymphoma of the adrenal gland is a rare presentation with <200 reported cases. We report a 70-year-old man who presented with vomiting and abdominal pain for 2 weeks and was subsequently diagnosed to have high-grade lymphoma of the adrenal glands. The patient was then started on a rituximab–bendamustine chemotherapy regimen. The patient tolerated treatment well without significant side effects. Repeat positron emission tomography CT scan after four cycles of chemotherapy showed complete response. The patient has completed six cycles of chemotherapy and is on regular follow-up with no signs of relapse.

https://ift.tt/2nE5iDK

Issue Information ‐ TOC

International Journal of Osteoarchaeology, Volume 28, Issue 4, Page 375-376, July/August 2018.


https://ift.tt/2MO7unb

Monozygotic twins with group C xeroderma pigmentosum due to a compound heterozygous mutation in XPC gene

The Journal of Dermatology, EarlyView.


https://ift.tt/2B8q5st

Gut microbiota alterations in moderate to severe acne vulgaris patients

The Journal of Dermatology, EarlyView.


https://ift.tt/2vHXi97

Severe thiopurine‐induced leukocytopenia and hair loss in Japanese patients with defective NUDT15 variant: Retrospective case–control study

The Journal of Dermatology, EarlyView.


https://ift.tt/2w6DImm

A Study to Evaluate the Safety and Tolerability of AB154 in Participants With Advanced Malignancies

Conditions:   Non-small Cell Lung Cancer;   Squamous Cell Carcinoma of the Head and Neck;   Renal Cell Carcinoma;   Breast Cancer;   Colorectal Cancer;   Melanoma;   Bladder Cancer;   Ovarian Cancer;   Endometrial Cancer;   Merkel Cell Carcinoma;   GastroEsophageal Cancer
Interventions:   Drug: AB154;   Drug: AB122
Sponsor:   Arcus Biosciences, Inc.
Not yet recruiting

https://ift.tt/2P6b9y5

A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies

Conditions:   Non-small Cell Lung Cancer;   Squamous Cell Carcinoma of the Head and Neck;   Breast Cancer;   Colorectal Cancer;   Melanoma;   Bladder Cancer;   Ovarian Cancer;   Endometrial Cancer;   Merkel Cell Carcinoma;   GastroEsophageal Cancer;   Renal Cell Carcinoma
Interventions:   Drug: AB928;   Drug: AB122
Sponsor:   Arcus Biosciences, Inc.
Recruiting

https://ift.tt/2Ba8jVF

Adaptive Tyrosine Kinase Inhibitor (TKI) Therapy In Patients With Thyroid Cancer

Conditions:   Thyroid Cancer;   Thyroid Cancer, Medullary;   Differentiated Thyroid Cancer;   Papillary Thyroid Cancer;   Follicular Thyroid Cancer;   Poorly Differentiated Thyroid Gland Carcinoma
Interventions:   Drug: Lenvatinib;   Drug: Sorafenib;   Drug: Cabozantinib;   Drug: Vandetanib
Sponsor:   H. Lee Moffitt Cancer Center and Research Institute
Recruiting

https://ift.tt/2P57tNb

Identification of gibberellin‐regulated protein as a new allergen in orange allergy

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nChzZb

Dietary patterns and respiratory health in adults from nine European countries – evidence from the GA2LEN study

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2BbW4rW

Inhibition of H3K27me3 demethylases attenuates asthma by reversing the shift in airway smooth muscle phenotype

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nAmauZ

Fluorescent Reporter Mice for Nerve Guidance Conduit Assessment: A High‐Throughput in vivo Model

The Laryngoscope, EarlyView.


https://ift.tt/2w5dEbm

First Successful Mechanical Splint for Obstructive Sleep Apnea With an Orally Administrable Pharyngeal Stenting Device

The Laryngoscope, EarlyView.


https://ift.tt/2MeazQZ

In Response to Upper Airway Stimulation Therapy and Prior Airway Surgery for Obstructive Sleep Apnea

The Laryngoscope, EarlyView.


https://ift.tt/2w6f5Gf

Upper Airway Stimulation in Patients With Obstructive Sleep Apnea and an Elevated Body Mass Index: A Multi‐institutional Review

The Laryngoscope, EarlyView.


https://ift.tt/2McvBQ1

Trigger Reduction Prior to Systemic Drugs for Neurogenic Chronic Cough

The Laryngoscope, EarlyView.


https://ift.tt/2w9V8OO

The Relationships Between the Nasolacrimal Duct and the Anterior Wall of the Maxillary Sinus

The Laryngoscope, EarlyView.


https://ift.tt/2McvDr7

Clinical Implications of Tumor‐Associated Tissue Eosinophilia in Tongue Squamous Cell Carcinoma

The Laryngoscope, EarlyView.


https://ift.tt/2MMz4RI

Initial and Long‐term Retention of Robotic Technical Skills in an Otolaryngology Residency Program

The Laryngoscope, EarlyView.


https://ift.tt/2MnwvID

An investigation of left–right vocal fold symmetry in rheological and histological properties

The Laryngoscope, EarlyView.


https://ift.tt/2w9V9Cm

Endonasal anatomy of the olfactory neural network: Surgical implications

The Laryngoscope, EarlyView.


https://ift.tt/2MqRTwL

Differential Distribution of Microtubules in Immature Osteocytes in vivo

Publication date: Available online 14 August 2018

Source: Journal of Oral Biosciences

Author(s): S.A. Murshid, T. Takano-Yamamoto, H. Kamioka

Abstract

Objectives

The transition from osteoblasts to osteocytes is associated with dramatic changes in the cytoskeleton. We previously showed that the formation of osteoblast cell processes in 3D culture is microtubule dependent. However, the distribution of microtubules during the transition from osteoblasts to osteocytes in vivo is unknown. In this study, we investigated the distribution of microtubules in osteocytes in vivo.

Methods

We observed the microtubules in osteocytes in chick embryonic calvaria via fluorescence staining of microtubules and confocal laser scanning microscopy.

Results

Microtubules were observed throughout the cytoplasm in all examined osteoblasts. In immature osteocytes, several cell processes contained microtubules, whereas in mature osteocytes, microtubules were localized only in the cell body.

Conclusion

These results suggest that the early arrangement of microtubules may be correlated with the initial development of osteocyte processes.

https://ift.tt/2nyYsPI

Automated classification of osteomeatal complex inflammation on computed tomography using convolutional neural networks

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2OB0p9Y

Highly multiplexed proteomic analysis reveals significant tissue and exosomal coagulation pathway derangement in chronic rhinosinusitis with nasal polyps

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2nySvSS

Pathogenic genes related to the progression of actinic keratoses to cutaneous squamous cell carcinoma

International Journal of Dermatology, EarlyView.


https://ift.tt/2KNMxH2

An inside look at prurigo pigmentosa: case report from Ukraine

International Journal of Dermatology, EarlyView.


https://ift.tt/2P8vov1

Sex hormones, erectile dysfunction, and psoriasis; a bad friendship!

International Journal of Dermatology, EarlyView.


https://ift.tt/2w5kqh7

Combining microneedling with other minimally invasive procedures for facial rejuvenation: a split‐face comparative study

International Journal of Dermatology, EarlyView.


https://ift.tt/2Miz7Z6

Lymphedema in patients with hidradenitis suppurativa: a systematic review of published literature

International Journal of Dermatology, EarlyView.


https://ift.tt/2w1Ob2m

Resident experiences with social media: modernizing dermatology training

International Journal of Dermatology, EarlyView.


https://ift.tt/2P8hOrt

Prevalence, risk factors, and mortality outcome in the drug reaction with eosinophilia and systemic symptoms patients with cardiac involvement

International Journal of Dermatology, EarlyView.


https://ift.tt/2KTcHIq

Hemoglobin as an indicator of disease activity in severe hidradenitis suppurativa

International Journal of Dermatology, EarlyView.


https://ift.tt/2MdvW4Q

Pemphigus vulgaris with vegetating feature confined to the scalp

International Journal of Dermatology, EarlyView.


https://ift.tt/2KTcxki

Secondary syphilis presented with impetigo‐like lesions: a rare case report

International Journal of Dermatology, EarlyView.


https://ift.tt/2MgzXWb

Unusual hair findings in a child with cardiofaciocutaneous syndrome

International Journal of Dermatology, EarlyView.


https://ift.tt/2w6fqZz

Euromelanoma in Portugal. How useful was the Euromelanoma campaign between 2010 and 2017?

International Journal of Dermatology, EarlyView.


https://ift.tt/2P1xGMx

Single question burden of disease assessment in patients referred for patch testing

International Journal of Dermatology, EarlyView.


https://ift.tt/2w9V95m

Atezolizumab‐associated vitiligo‐like leukoderma in a patient with transitional cell carcinoma

International Journal of Dermatology, EarlyView.


https://ift.tt/2MhzWRO

Impact of tumour profiling on clinical trials in salivary gland cancer

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2P85w2d

Undergraduate ear, nose and throat training: How do we inspire the next generation? Response to author

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KRZ5Np

Endoscopic approach in one hundred and seventy‐nine patients of dacryocystorhinostomy

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MctYBT

Modified fiberscope‐guided nasogastric tube insertion: Our experience with 23 patients

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2w48A75

A Helpful Technique for Increasing the Size of a Tracheostomy Window in Patients with Calcified or Challenging Tracheas Utilising a Kerrison Punch Forceps

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Met6MV

Radiological Parameters Related to Success of the Round Window Approach in Cochlear Implantation: A retrospective study

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2KRYN9h

Descriptive Epidemiology of Salivary Gland Neoplasms in Nigeria: an AOPRC multi‐centre tertiary hospital study

Oral Diseases, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MKt6R9

Novel dlx3 variants in amelogenesis imperfecta with attenuated tricho‐dento‐osseous syndrome

Oral Diseases, Volume 0, Issue ja, -Not available-.


https://ift.tt/2ModndK

Predicting cancer outcome: Artificial Intelligence vs Pathologists

Oral Diseases, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MKsXgz

Salivary proteins and peptides in the aetiology of caries in children: systematic literature review

Oral Diseases, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Mpu7Ba

Dental imaging of trabecular bone structure for systemic disorders screening:a systematic review

Oral Diseases, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MKrB5z

Editorial Board

Publication date: September 2018

Source: Autoimmunity Reviews, Volume 17, Issue 9

Author(s):

https://ift.tt/2nEuUQW

Comparing childhood-versus adult-onset polyarteritis nodosa. Results from the French Vasculitis Study Group Registry

Publication date: Available online 14 August 2018

Source: Autoimmunity Reviews

Author(s): Michele Iudici, Pierre Quartier, Christian Pagnoux, Etienne Merlin, Christian Agard, Achille Aouba, Pascal Roblot, Pascal Cohen, Benjamin Terrier, Luc Mouthon, Loïc Guillevin, Xavier Puéchal, the French Vasculitis Study Group

Abstract

Objective

To investigate differences between childhood (cPAN)- and adult-onset polyarteritis nodosa (aPAN) patients.

Methods

cPAN patients' clinical findings at onset and outcomes were compared to those of aPAN patients from the French Vasculitis Study Group registry matched for year of enrollment and initial systemic versus cutaneous disease. Their information on medications, disease activity and damage were collected. Kaplan–Meier relapse-free survival curves and the log-rank test were used to analyze cPAN versus aPAN differences for predefined outcomes.

Results

Twenty-one children with systemic and 13 with cutaneous PAN were compared with 84 systemic- and 27 cutaneous-matched aPAN patients. Median follow-up exceeded 5 years for both groups. At study entry, mononeuritis multiplex was less frequent in systemic cPAN than systemic aPAN (P = 0.04), and purpura and myalgias were less frequent in cutaneous cPAN than cutaneous aPAN (P < 0.03). During follow-up, systemic cPAN relapsed more often than matched systemic aPAN (P < 0.0001), while relapse rates were similar for cutaneous disease (P > 0.05). Mostly minor relapses, predominantly involving the skin, occurred in all 4 groups. At last visit, damage accrual was comparable for cPAN and aPAN patients, but fewer systemic cPAN patients were treatment-free (15% versus 42%; P = 0.03). Two (6%) cPAN and 8 (7%) aPAN patients died.

Conclusion

Systemic PAN is equally severe in children and adults and carries a higher risk of relapse. The main cutaneous PAN features seem not to be influenced by age at disease onset.

https://ift.tt/2OADCuL

Different dermoscopic features of clonal seborrheic keratoses

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2vJJSJH

Ustekinumab Exposure during Conception and Pregnancy in Patients with Chronic Plaque Psoriasis – a case series of 10 pregnancies

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2vJJZF7

Are photosensitizing medications associated with increased risk of important erythemal reactions during ultraviolet B phototherapy?

British Journal of Dermatology, EarlyView.


https://ift.tt/2ODIAHp

Tofacitinib in patients with moderate‐to‐severe chronic plaque psoriasis: long‐term safety and efficacy in an open‐label extension study

British Journal of Dermatology, EarlyView.


https://ift.tt/2vJKeA1

Why we continue to use the name Propionibacterium acnes

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2ODIob9

Why a randomised melanoma screening trial may be a good idea

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2OzRsxn

Folliculotropic Mycosis fungoides associated with GATA2 deficiency: a new skin manifestation

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2ODI4cr

Measurement of cytokines, chemokines and association with clinical severity of DM/CADM disease

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nDKQ60

Acne: A Side Effect of Masculinizing Hormonal Therapy in Transgender Patients

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2ODHZp9

Laser Treatments in Early Wound Healing Improve Scar Appearance: ‐A Randomized Split‐Wound Trial with Non‐ablative Fractional Laser Exposures versus Untreated Controls

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nCGQ5J

Drug‐free microneedles in the treatment of keloids: a single‐blinded intra‐individual controlled clinical trial

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Oua9T6

The frequency of specific contact allergies is reduced in psoriasis patients

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nDL4Ko

An ex‐vivo RNA trans‐splicing strategy to correct human generalized severe epidermolysis bullosa simplex

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2OBRK73

Children sustain high levels of skin DNA photodamage, with a modest increase of serum 25‐hydroxyvitamin D3, after a summer holiday in Northern Europe

British Journal of Dermatology, EarlyView.


https://ift.tt/2nDKkF6

Infectious events and associated risk factors in Mycosis Fungoides/Sézary Syndrome: a retrospective cohort study

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2OCFUtv

Use of topical antipsoriatic drugs in Denmark: A nationwide drug utilization study

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2vJJ4EF

Outcomes in thread lift for face and neck: A study performed with Silhouette Soft and Promo Happy Lift double needle, innovative and classic techniques

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2vEVSfk

Comparison of therapeutic effects of conventional and liposomal form of 4% topical hydroquinone in patients with melasma

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2B4PYJP

Quality of life before and after cosmetic procedures on the face: A cross‐sectional study in a public service

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2Miv4vS

The new therapeutic choice of tranexamic acid solution in treatment of erythematotelangiectatic rosacea

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2w7Jl3F

Sparing subcutaneous septa avoids skin necrosis in the treatment of axillary bromhidrosis with suction‐curettage shaving

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2vInaBB

Das hepatozelluläre Karzinom – pathologische und molekularpathologische Diagnostik

Zusammenfassung

Hintergrund

Das hepatozelluläre Karzinom (HCC) ist histopathologisch definiert. Histo- und molekularpathologische Diagnostikverfahren sind Grundlage einer stadiengerechten Therapie, aber auch therapeutischer Innovation. Basierend auf klassischen histologischen Charakteristika wurden in den letzten Jahren vielfältige Verbesserungen hin zu einer modernen, morphomolekularen Diagnostik des HCC erreicht: multiple neue Marker zur Präzisierung der Differenzial- und insbesondere Malignitätsdiagnose bei hochdifferenzierten Lebertumoren; Definition neuer tumorbiologisch definierter und relevanter HCC-Subtypen, die bis zu 30 % der HCC betreffen; molekulare Zielstrukturen und potenzielle prädiktive Marker für präzisionsonkologische Ansätze. Dies sind Bausteine einer neuen morphomolekularen Klassifikation des HCC, die eine wesentliche zukünftige Herausforderung darstellt.

Künftige Anforderungen

Es muss nicht nur eine neue morphomolekulare Klassifikation erstellt werden, sondern auch die Position der Biopsiediagnostik des HCC bedarf einer grundlegenden Verbesserung. Zudem müssen neue immunonkologische Ansätze diagnostisch sinnvoll untermauert werden und die neuen Erkenntnisse in entsprechend geplanten Studien und auch geeigneten zentrenbasierten Ansätzen diagnostisch und klinisch umgesetzt werden, um die in Bezug auf andere relevante Tumorarten immer noch unbefriedigende klinische Position des HCC nachhaltig zu verbessern.

https://ift.tt/2vIG7UO

Decreased gastrostomy tube incidence and weight loss after transoral robotic surgery for low‐ to intermediate‐risk oropharyngeal squamous cell carcinoma

Head &Neck, EarlyView.


https://ift.tt/2Mc74ut

Adverse pathologic features in T1/2 oral squamous cell carcinoma classified by the American Joint Committee on Cancer eighth edition and implications for treatment

Head &Neck, EarlyView.


https://ift.tt/2KQDUeM

Stent grafts in patients with carotid blowout syndrome: Outcome and antiplatelet therapy in preventive versus emergency cases

Head &Neck, EarlyView.


https://ift.tt/2P9CSy2

Transcriptome analysis of papillary thyroid cancer harboring telomerase reverse transcriptase promoter mutation

Head &Neck, EarlyView.


https://ift.tt/2wejpnd

Antiproliferative potential of miR‐33a in laryngeal cancer Hep‐2 cells via targeting PIM1

Head &Neck, EarlyView.


https://ift.tt/2P8ZvTd

Platelet count and platelet‐lymphocyte ratio as prognostic markers for head and neck squamous cell carcinoma: A meta‐analysis

Head &Neck, EarlyView.


https://ift.tt/2w7Jggn

Analysis of readmissions after transoral robotic surgery for oropharyngeal squamous cell carcinoma

Head &Neck, EarlyView.


https://ift.tt/2Mj7yPC

Predictors of graft function after parathyroid autotransplantation during thyroid surgery

Head &Neck, EarlyView.


https://ift.tt/2w5x8fO

Psoriasis dermatitis: an overlap condition of psoriasis and atopic dermatitis in children

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nza8Ca

PUVA and interferon‐α2b combined therapy for patients with mycosis fungoides at different stages of the disease: a seven‐year retrospective study in Russia

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2OAcvjH

Reply to: “S2k guideline for treatment of cutaneous lupus erythematosus ‐ guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV)”

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2P4Wof3

Role of Galectin‐3 in subclinical myocardial impairment in psoriasis

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Ozp92g

Reply to the letter by Pindado‐Ortega et al

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nBAIKX

Chemotherapy‐induced alopecia ‐ the urgent need for treatment options

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2B73Y5C

ΜelanoQ: A Consensus Questionnaire of Standardized Epidemiologic and Clinical Variables for Melanoma Risk Assessment by the MelaNostrum Consortium

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2nDJzMg

TIPE2 sensitizes osteosarcoma cells to cis-platin by down-regulating MDR1 via the TAK1- NF-κB and - AP-1 pathways

Publication date: September 2018

Source: Molecular Immunology, Volume 101

Author(s): Peiqing Zhao, Sujie Wang, Jie Jiang, Hong Liu, Xiaolan Zhu, Ning Zhao, Jigang Li, Yingchun Yin, Xiaoyan Pan, Xiuzhen Yang, Jianping Guo, Wenlin Xu

Abstract

TIPE2 participates in multiple types of cancer development. However, its mechanism underlying chemoresistance in osteosarcoma has not been elucidated. Herein, we observed the expression of TIPE2 and MDR1 in cis-platin-resistant osteosarcoma tissues and cell lines. Compared to their matched sensitive cell lines and tissues, TIPE2 was downregulated while MDR1 expression was increased. Further investigation showed that overexpression of TIPE2 effectively inhibited MDR1 expression and greatly sensitized osteosarcoma cells to cis-platin, both in vivo and in vitro. Mechanistically, TIPE2 inhibited the transcription of the MDR1 promoter by interfering with the TAK1-NF-κB and -AP-1 pathways. Overall, our results elucidated for the first time that TIPE2 sensitizes osteosarcoma cells to cis-platin through downregulation of MDR1 and may be a novel target in osteosarcoma therapy.

https://ift.tt/2KTc8yb

The role of environmental factors in allergy: A critical reappraisal

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MlWjVv

Differential Expression of lncRNAs and predicted target genes in normal mouse melanocytes and B16 cells

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MKvwiT

Decorin promotes proliferation and migration of ORS keratinocytes and maintains hair anagen in mice

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MlWd05

Peptide nucleic acid‐probe based analysis to detect filaggrin mutations in atopic dermatitis patients

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MKYhvy

MAP4 regulates Tctex‐1 and promotes the migration of epidermal cells in hypoxia

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MiOOPp

Functional characterization of the extranasal OR2A4/7 expressed in human melanocytes

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MNnjul

MRGPRX2 is negatively targeted by SCF and IL‐4 to diminish pseudo‐allergic stimulation of skin mast cells in culture

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MlVMTv

LGI3 promotes human keratinocyte differentiation via the Akt pathway

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MNn02F

Indications for partial parotidectomy using retrograde dissection of the marginal mandibular branch of the facial nerve for benign tumours of the parotid gland

Publication date: Available online 14 August 2018

Source: British Journal of Oral and Maxillofacial Surgery

Author(s): K. Suzuki, H. Iwai, M. Yagi, T. Fujisawa, A. Kanda, M. Konishi, Y. Kobayashi, K. Tomoda, T. Yamashita

Abstract

The aims of this study were to evaluate the efficacy of partial parotidectomy using retrograde dissection of the marginal mandibular branch of the facial nerve for benign tumours of the parotid gland and to establish the indications for its use. We examined 106 consecutive patients with previously untreated benign tumours in the lower portion of the parotid gland who were treated by parotidectomy. The first group (anterograde group, n=52) consisted of those who had standard anterograde parotidectomy. The remaining patients, who underwent retrograde parotidectomy, were further divided into two groups: those in whom the upper edge of the tumour was located below the mastoid tip (below mastoid group, n=46) or those in whom it was above the mastoid tip (above mastoid group, n=8). The operating time was significantly shorter in the below mastoid group (141.2, 127.5, and 98.1 minutes, respectively) as was intraoperative blood loss (41.1, 53.0, and 24.4 ml, respectively), compared with the other two groups. There was a higher incidence of facial nerve dysfunction in the above mastoid group postoperatively (4/8) than in the other two groups. The results suggested that the presence of a tumour of any size located below the mastoid tip is a good indication for parotidectomy using retrograde dissection of the marginal mandibular branch of the facial nerve.

https://ift.tt/2w7V02n

Development and characterization of DNAzyme candidates demonstrating significant efficiency against human rhinoviruses

Publication date: Available online 14 August 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Daniel P. Potaczek, Sebastian D. Unger, Nan Zhang, Styliani Taka, Sven Michel, Nesibe Akdağ, Feng Lan, Markus Helfer, Christoph Hudemann, Markus Eickmann, Chrysanthi Skevaki, Spyridon Megremis, Anne Sadewasser, Bilal Alashkar Alhamwe, Fahd Alhamdan, Mübeccel Akdis, Michael R. Edwards, Sebastian L. Johnston, Cezmi A. Akdis, Stephan Becker

Abstract

Background

Infections with human rhinoviruses (RVs) are responsible for millions of common cold episodes and the majority of asthma exacerbations, especially in childhood. No drugs specifically targeting RVs are available.

Objective

To identify specific anti-rhinoviral molecules based on DNAzyme technology as candidates to a clinical study.

Methods

A total of 226 candidate DNAzymes were designed against two regions of RV RNA genome identified to be sufficiently highly conserved between virus strains, i.e. 5'-untranslated (5'-UTR) and cis-acting replication element (CRE), by use of three test strains, RVA1, -A16, and -A29. All DNAzymes were screened for their cleavage efficiency against in vitro-expressed viral RNA. Those showing any catalytic activity were subjected to bioinformatic analysis of their reverse complementarity to 322 published rhinoviral genomic sequences. Further molecular optimization was conducted for most promising candidates. Cytotoxic and off-target effects were excluded in HEK293-cell-based systems. Antiviral efficiency was analyzed in infected human bronchial BEAS-2B cells and ex vivo-cultured human sinonasal tissue.

Results

Screening phase generated DNAzymes characterized by either good catalytic activity or by high RV strain coverage but no single molecule represented a satisfactory combination of those two features. Modifications in length of the binding domains of two lead candidates, Dua-01(-L12R9) and Dua-02(-L10R11), improved their cleavage efficiency to an excellent level with no loss in eminent strain coverage (about 98%). Both DNAzymes showed highly favorable cytotoxic/off-target profiles. Subsequent testing of Dua-01-L12R9 in BEAS-2B cells and sinonasal tissue demonstrated its significant antiviral efficiency.

Conclusions

Effective and specific management of RV infections with Dua-01-L12R9 might be useful in preventing asthma exacerbations, which should be verified by clinical trials.

Graphical abstract

https://ift.tt/2vHFzP4

School-Supervised Use of a Once-Daily Inhaled Corticosteroid Regimen: A Cluster Randomized Trial

Publication date: Available online 14 August 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Joe K. Gerald, Julia M. Fisher, Mark A. Brown, Conrad J. Clemens, Melissa A. Moore, Scott C. Carvajal, Donna Bryson, Nikki Stefan, Dean Billheimer, Lynn B. Gerald

Background

School-supervised use of a once-daily inhaled corticosteroid regimen (supervised therapy) can improve medication adherence and asthma control.

Objective

To evaluate the effectiveness of supervised therapy in a unique setting and population.

Methods

We conducted a cluster-randomized trial of supervised therapy in 20 elementary schools with a disproportionate enrollment of low income Latino students. Schools were purposively selected, matched, and randomized to receive 9-months of supervised therapy with mometasone furoate or usual care. All English- or Spanish-speaking students with self-reported asthma were eligible. The Asthma Control Questionnaire (ACQ) was interviewer-administered quarterly at school. Students in supervised therapy schools were hypothesized to have lower ACQ scores than students in usual care schools.

Results

Of 393 enrolled students, 189 immediate intervention and 143 delayed intervention students provided ≥1 ACQ data point, were between 6 - 10 years of age, and were included in the primary analysis. At baseline, 39% of students reported taking a controller medication and 24% had well-controlled asthma. Eighty percent of immediate intervention students were prescribed mometasone. Schools administered 98% of prescribed doses when students attended school. Absences, weekends, and holidays reduced calendar adherence to 53%. During the first year, the mean ACQ score for immediate and delayed intervention students was 1.55 (95% CI 1.41, 1.70) and 1.64 (95% CI 1.47, 1.80), respectively. The estimated treatment effect was -0.08 (95% CI -0.31, 0.14).

Discussion

Compared to usual care, supervised therapy did not improve asthma control among this population of Latino students. Additional research is warranted to confirm these results.

Graphical abstract

https://ift.tt/2Ba4vnx

Non-calcifying Langerhans Cell-Rich Variant of Calcifying Epithelial Odontogenic Tumor: A Distinct Entity with Predilection for Anterior Maxilla

Abstract

Calcifying epithelial odontogenic tumor (CEOT) is an uncommon locally invasive epithelial odontogenic tumor of the jaws associated with amyloid production. Intraosseous presentations are most common and they frequently occur in the posterior mandible. A non-calcifying Langerhans cell-rich variant of CEOT (NCLC CEOT) has been described with predilection for the anterior maxilla. Interestingly, all reported cases of NCLC CEOT have occurred in Asian population. We present a case of a 43-year old Caucasian female with a large radiolucent lesion involving the left anterior maxilla with histologic features of NCLC CEOT. This is the first reported case of this rare variant of CEOT in a Caucasian individual.

https://ift.tt/2MH109y

Inactivation of Fam20b in the neural crest‐derived mesenchyme of mouse causes multiple craniofacial defects

European Journal of Oral Sciences, EarlyView.


https://ift.tt/2Mljboa

Non-calcifying Langerhans Cell-Rich Variant of Calcifying Epithelial Odontogenic Tumor: A Distinct Entity with Predilection for Anterior Maxilla

Abstract

Calcifying epithelial odontogenic tumor (CEOT) is an uncommon locally invasive epithelial odontogenic tumor of the jaws associated with amyloid production. Intraosseous presentations are most common and they frequently occur in the posterior mandible. A non-calcifying Langerhans cell-rich variant of CEOT (NCLC CEOT) has been described with predilection for the anterior maxilla. Interestingly, all reported cases of NCLC CEOT have occurred in Asian population. We present a case of a 43-year old Caucasian female with a large radiolucent lesion involving the left anterior maxilla with histologic features of NCLC CEOT. This is the first reported case of this rare variant of CEOT in a Caucasian individual.

https://ift.tt/2MH109y

A Contemporary Perspective on the Management of Post-Craniotomy Headache and Pain

Abstract

Purpose of Review

This article discusses the etiology and management of post-craniotomy headache and pain. A review of available as well as investigatory treatment modalities is offered, followed by suggestions for optimal management of post-craniotomy headache.

Recent Findings

There is a dearth of evidence-based practice regarding the differential diagnosis, natural history, and management of post-craniotomy headache. The etiology of post-craniotomy headache is typically multifactorial, with patients' medical history, type of craniotomy, and perioperative management all playing a role. Post-craniotomy headaches are often undertreated, yet available evidence supports a multimodal approach for both prophylaxis and management. Many therapeutic techniques that aim to treat or prevent post-craniotomy headache require more robust validation than clinical evidence currently imparts. Pre- and intraoperative locoregional anesthesia should be the mainstay of prophylaxis; the role of opiates co-administered with analgesics, corticosteroids, and antiepileptic therapy in the acute perioperative phase is of paramount importance. Treatment of chronic PCH is less well-defined but should involve trials of analgesic, antineuropathic, and antiepileptic medications before enlisting experimental treatments. Comorbid psychiatric, musculoskeletal, or seizure disorders should be managed distinctly from post-craniotomy headaches. In patients failing all extant therapies, experimental approaches should be considered. These include subanesthetic ketamine infusion or surgical site injection with local anesthetics, corticosteroids, or botulinum toxin.

Summary

Post-craniotomy headache is a complex phenomenon with many underutilized treatment options available, and many more under investigation. Nonetheless, further research is required to differentiate the efficacy of contemporary treatment strategies and to elucidate the applicability of novel therapies.

https://ift.tt/2vGayuU

Non-calcifying Langerhans Cell-Rich Variant of Calcifying Epithelial Odontogenic Tumor: A Distinct Entity with Predilection for Anterior Maxilla

Abstract

Calcifying epithelial odontogenic tumor (CEOT) is an uncommon locally invasive epithelial odontogenic tumor of the jaws associated with amyloid production. Intraosseous presentations are most common and they frequently occur in the posterior mandible. A non-calcifying Langerhans cell-rich variant of CEOT (NCLC CEOT) has been described with predilection for the anterior maxilla. Interestingly, all reported cases of NCLC CEOT have occurred in Asian population. We present a case of a 43-year old Caucasian female with a large radiolucent lesion involving the left anterior maxilla with histologic features of NCLC CEOT. This is the first reported case of this rare variant of CEOT in a Caucasian individual.

https://ift.tt/2MH109y

Erratum zu: Update zur systemischen Therapie bei fortgeschrittenem hepatozellulärem Karzinom

Erratum zu:

Der Onkologe 2018

https://ift.tt/2MolCpT

Im Abschnitt zur Zweitlinientherapie mit „Ramucirumab" muss es korrekt heißen, dass in der anhand des AFP-Werts vorselektionierten Patientenpopulation eine signifikante Verbesserung des Überlebens erreicht werden konnte. Der …

https://ift.tt/2KSaFYS