Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2MPWdmD
Παρασκευή 22 Ιουνίου 2018
Personal observations of Achenbach syndrome
Evolution of Kaposi sarcoma in the past 30 years in a tertiary hospital of the European Mediterranean basin
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2ttc3ux
Eosinophilic Gastrointestinal Diseases (EGIDs) beyond Eosinophilic Esophagitis (EoE)
Publication date: Available online 22 June 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Maureen Egan, Glenn T. Furuta
ObjectiveEosinophilic Gastrointestinal Diseases (EGIDs) are a rare group of disorders that can have varied clinical presentations dependent on the involved segment within the gastrointestinal tract. Eosinophilic gastritis presents with abdominal pain or vomiting; Eosinophilic gastroenteritis presents with diarrhea and anemia/hypoalbuminemia and Eosinophilic colitis can present with diarrhea or bloody stools. These nonspecific symptoms remain poorly understood as to their relationship to the underlying pathogenesis but a significant percentage of patients are atopic. Here we discuss the current literature on EGIDs to promote a practical approach to the diagnosis and care.Data SourcesReview of published literatureStudy SelectionsClinically relevant literature from 1900-2018 was obtained from a PubMed search. Those which addressed prevalence, diagnosis, clinical manifestations, natural history and treatment of EGID's were reviewed and are summarized here.ResultsOf the total 485 articles found in the search, majority of which were case reports, 71 were selected for review. The natural history of EGIDs is based primarily on case series and small numbers of patients making therapeutic decisions difficult. Treatment remains limited to dietary restriction that is not effective in many patients and topical or systemic corticosteroids whose long-term use is to be avoided if possible.ConclusionsWith the seeming increase in all types of EGIDs, phenotypic descriptions are emerging that will likely promote better understanding of the pathogenesis and identification of novel therapeutic targets.
https://ift.tt/2KaE7K5
Immunoglobulin and T cell receptor genes in Chinese crocodile lizard Shinisaurus crocodilurus
Source:Molecular Immunology, Volume 101
Author(s): Francisco Gambón-Deza, David N. Olivieri
Squamata are reptiles that diverged from mammals 300 million years ago. During this period, the immunoglobulin (IG) and T lymphocyte receptor (TCR) genes evolved parallel to mammals. However, unlike mammals whose IG/TCR locus has retained a constant structure throughout evolution, Squamata have witnessed duplications, losses, and/or gains in the domains of their immunoglobulin genes. The recent genome sequencing of Shinisaurus crocodilurus, a representative species of the oldest reptiles, provides an opportunity to contrast the structure of IG and TCR genes from previously studied Squamata. This study revealed ten immunoglobulin genes: five genes for immunoglobulin M (IgM), two for immunoglobulin D (IgD), one for immunoglobulin D2 (IgD2), and two for immunoglobulin Y (IgY). As in other Squamata, there are genes for the λ light chain (IGLV) but not for the κ chain (IGKV). Here, the data shows that in some IgM genes, the cysteine needed to bind the λ chains does not exist, but we present evidence for possible non-covalent binding to the light chain. With respect to TCR, one gene is detected for the α constant chain (TRAC) and two genes for the β constant chain (TRBC); one of which is located in the locus of the variable regions of the heavy chain. As in the rest of the Squamata, genes for the γ/δ T cell receptor were not found. The V gene repertoire is found to be consistent with all other Squamata with few V genes for beta chain of TCR.
https://ift.tt/2MbQ4Qk
Acquired and genetic host susceptibility factors and microbial pathogenic factors that predispose to nontuberculous mycobacterial infections
Jennifer R Honda | Scott Alper | Xiyuan Bai | Edward D Chan
https://ift.tt/2yChuwU
Treatment Paradigm for Nasal Airway Obstruction
Nasal airway obstruction (NAO) is a common otolaryngic complaint with many potential causes, frequently structural or inflammatory in nature. Patients typically have multiple coexisting factors leading to symptoms. Good patient outcomes require careful preoperative evaluation, including nasal endoscopy, to accurately identify sources of obstruction and tailor intervention appropriately. Common structural causes of NAO include inferior turbinate hypertrophy, nasal septal deviation, and narrowing or collapse of the internal or external nasal valves. The internal nasal valve has the narrowest cross-sectional area within the nasal airway and is thus most sensitive to changes in dimension due to anatomic variation or surgical intervention.
https://ift.tt/2MRizUM
Anatomy and Physiology of Nasal Obstruction
Nasal obstruction is a common presenting symptom to clinicians and affects up to one-third of the population. There are several factors that cause nasal obstruction, including anatomic, physiologic, and pathophysiologic factors. The anatomy and physiology of nasal obstruction is complicated and is influenced by patency of nasal passages, mucociliary function, airflow receptors, autonomic function, and degree of mucosal inflammation. Common anatomic causes include internal nasal valve stenosis/collapse, septal deviation, and turbinate hypertrophy. Common physiologic causes include sinonasal inflammatory disorders and iatrogenic causes.
https://ift.tt/2yz0k3f
Utility of narrow band imaging in the diagnosis of middle turbinate head edema
Middle turbinate head edema has recently been found to have high specificity for diagnosis of inhalant allergy. However, subtle mucosal edema can be difficult to appreciate under white light endoscopy. Narrow band imaging (NBI) has the potential to demonstrate edema by identifying reduced mucosal vascularity and improve sensitivity for the detection of mucosal edema. Narrow band imaging was assessed to determine its utility in objectifying mucosal edema.
https://ift.tt/2tpQISG
Effects of combination of balloon Eustachian tuboplasty with methylprednisolone irrigation on treatment of chronic otitis media with effusion in adults
Adult chronic otitis media with effusion (COME) is characterized by Eustachian tube dysfunction and mucosal inflammation, which management has long been a challenge because of high recurrence. This study was to investigate the pathological changes of Eustachian tube mucosa and optimized treatment.
https://ift.tt/2lrh2YZ
Stereotactic radiotherapy in three weekly fractions for the management of vestibular schwannomas
This study evaluates the rates of tumor control, hearing preservation and cranial nerve toxicity with the use of CyberKnife stereotactic radiotherapy consisting of 2100 cGy to the 80% isodose line delivered in three weekly fractions to treat vestibular schwannomas.
https://ift.tt/2yz2tvJ
Understanding Caregiver Goals, Benefits, and Acceptable Risks of Peanut Allergy Therapies
Peanut allergy affects 1.4-4.5% of children and may be a lifelong allergy in 75%.1 Nearly 50% of peanut allergic individuals have had a past severe reaction.2 Several promising peanut allergy treatments are under development.3 Peanut allergy is associated with anxiety and poor quality of life (QoL) in the child and caregiver, driven by fear the child will react from an accidental exposure—something treatment could prevent.4–10 For these reasons, two therapies, peanut oral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT), have been granted US Food and Drug Administration (FDA) fast-track status.
https://ift.tt/2ttcCVh
Eosinophilic Gastrointestinal Diseases (EGIDs) beyond Eosinophilic Esophagitis (EoE)
Eosinophilic Gastrointestinal Diseases (EGIDs) are a rare group of disorders that can have varied clinical presentations dependent on the involved segment within the gastrointestinal tract. Eosinophilic gastritis presents with abdominal pain or vomiting; Eosinophilic gastroenteritis presents with diarrhea and anemia/hypoalbuminemia and Eosinophilic colitis can present with diarrhea or bloody stools. These nonspecific symptoms remain poorly understood as to their relationship to the underlying pathogenesis but a significant percentage of patients are atopic.
https://ift.tt/2lqEpC1
A difficult situation – balancing critical anticoagulation versus the risk of permanent neurologic deficit: a case report
Anticoagulation is the mainstay of treatment for pulmonary embolism. However, if bleeding unfortunately occurs, the risks and benefits of anticoagulation present a challenge. Management of one hemorrhagic comp...
https://ift.tt/2K8BMiW
Anterior hypopituitarism in a patient with amyloidosis secondary to Crohn’s disease: a case report
Amyloid infiltration of endocrine glands has been reported, mostly in the thyroid, pancreas, adrenals, and testes, but affected patients do not frequently exhibit overt endocrine insufficiency. Here we report ...
https://ift.tt/2K1xXjI
Virtual reality head-mounted display for endoscopically-assisted implant surgery
Virtual reality (VR) is of potential use to surgeons,1 but means that they must interrupt the operation to watch the monitor.2 A head-mounted display is the most popular wearable device to create VR images, and is already used in some specialties.3
https://ift.tt/2lvb21A
Letter to the editor: “Utility of PET-CT in detecting nodal metastasis in cN0 early stage oral cavity squamous cell carcinoma”
To the editor:
https://ift.tt/2tvxM58
The possible contemporary presence of BRONJ and oral squamous cell carcinoma
Dear Editor,
https://ift.tt/2lwJpox
Efficacy of corticosteroids versus placebo in impacted third molar surgery: systematic review and meta-analysis of randomized controlled trials
The aim of this systematic review was to identify randomized, placebo-controlled clinical trials investigating the effectiveness of corticosteroids in the control of pain, oedema, and trismus following third molar surgery, and to analyse the effects of the type of drug administered and the time and route of drug administration on the outcomes of interest. Searches were performed in the PubMed, Scopus, and Cochrane Library databases. This review was structured according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.
https://ift.tt/2MRyK4f
Tips for dyeing hair when you have psoriasis
People with psoriasis can dye their hair safely. However, there are factors to consider before, during, and after applying the dye. In this article, learn about the risks, and seven tips developed to help people with psoriasis to dye their hair safely. We also describe how to prevent flare-ups on the scalp.
https://ift.tt/2MfVASl
Anesthetic management without perioperative platelet transfusion for cervical laminectomy and laminoplasty in a case of May–Hegglin anomaly
Abstract
May–Hegglin anomaly (MHA) is an inherited autosomal dominant disorder characterized by giant platelets and inclusion bodies in granulocytes, and thrombocytopenia. There is no consensus on the perioperative management of this disorder. We report a case involving a patient with MHA who was perioperatively managed without platelet transfusion for cervical laminectomy and laminoplasty. In our case, the platelet count was measured to be 0.6 × 104/µL using an automatic blood cell counter. Peripheral blood smear and genetic test analyses were performed, leading to a definitive diagnosis of MHA. However, clot retraction, serotonin release, and platelet aggregation were normal. Total intravenous anesthesia with propofol and remifentanil, in combination with intermittent injection of fentanyl, was administered. The total blood loss volume was 300 mL, and perioperative course was uneventful. Visual platelet count and platelet function were preserved in this case, although platelet or red blood cell transfusion was not performed. No bleeding tendency was observed during perioperative management.
https://ift.tt/2yBo5ry
Which treatments work for stretch marks?
Stretch marks are common during periods of sudden growth. While they often fade over time, they can be permanent. Some people try to reduce the appearance of these marks at home using creams or lotions, herbal remedies, self-tanner, or hyaluronic acid. Here, we explore the evidence behind popular methods.
https://ift.tt/2Ma7Vak
Vertebral anomalies in craniofacial microsomia: a retrospective analysis of 991 patients
Source:International Journal of Oral and Maxillofacial Surgery
https://ift.tt/2yz9zRf
Editorial Board/Reviewing Committee
Source:International Journal of Oral and Maxillofacial Surgery, Volume 47, Issue 8
https://ift.tt/2lq1yVb
The clinical outcome of skeletal anchorage in interceptive treatment (in growing patients) for class III malocclusion
Publication date: August 2018
Source:International Journal of Oral and Maxillofacial Surgery, Volume 47, Issue 8
Author(s): J. Meyns, D.M. Brasil, J.F. Mazzi-Chaves, C. Politis, R. Jacobs
A systematic review of the literature was performed regarding the clinical outcome (effectiveness) of bone anchorage devices in interceptive treatment for class III malocclusion. A search of Embase, PubMed and Web of Science databases yielded 285 papers. An additional two articles were retrieved through manual searching of the reference lists. After initial abstract selection, 32 potentially eligible articles were screened in detail, resulting in a final number of eight articles included in this review. Insufficient evidence was found regarding the effects of skeletal anchorage in interceptive class III treatment to support definitive conclusions on long-term skeletal effects and stability.In the short term, it seems that bone anchors can provide more skeletal effect with less dentoalveolar compensations and less unwanted vertical changes. This does not always exclude the use of a face mask. The use of miniscrews as skeletal anchorage device does not seem to provide more skeletal effect, although it could minimize the unwanted dental effects in the upper jaw. No information regarding the need for orthognathic surgery, orthodontic treatment time or patient compliance and complications was found in the selected articles.
https://ift.tt/2yBneXS
Can platelet-rich fibrin accelerate neurosensory recovery following sagittal split osteotomy? A double-blind, split-mouth, randomized clinical trial
Publication date: August 2018
Source:International Journal of Oral and Maxillofacial Surgery, Volume 47, Issue 8
https://ift.tt/2lrmJpS
The sequential treatment of temporomandibular joint ankylosis with secondary deformities by distraction osteogenesis and arthroplasty or TMJ reconstruction
Publication date: August 2018
Source:International Journal of Oral and Maxillofacial Surgery, Volume 47, Issue 8
Author(s): W. Zhang, X. Yang, Y. Zhang, T. Zhao, J. Jia, S. Chang, Y. Liu, Bo Yu, Y. Chen, Q. Ma
The purpose of this study was to evaluate the sequential treatment of patients with temporomandibular joint (TMJ) ankylosis and secondary deformities by distraction osteogenesis and subsequent arthroplasty or TMJ reconstruction. This study included 40 patients treated at a stomatological hospital in China; they ranged in age from 9 to 53years (mean age 24.5years). Ten of these patients were diagnosed with unilateral TMJ ankylosis and 30 with bilateral TMJ ankylosis. Twenty-seven patients also presented obstructive sleep apnoea–hypopnoea syndrome (OSAHS). All patients underwent distraction osteogenesis as the initial surgery, followed by arthroplasty or TMJ reconstruction. Some patients underwent orthognathic surgery to improve occlusion and face shape along with or after arthroplasty or TMJ reconstruction. The therapeutic effects were evaluated in terms of the improvements in maximum inter-incisal opening (MIO), appearance, and respiratory function. After the completion of treatment, all patients showed improvements in MIO and appearance, and the symptom of snoring disappeared. The airway space was significantly increased. Patient follow-up ranged from 6 to 85months (mean 28.3months), and four patients experienced relapse. This study suggests that treating TMJ ankylosis with secondary deformities by distraction osteogenesis as the initial surgery and arthroplasty or TMJ reconstruction as the second-stage treatment may achieve favourable outcomes, especially for patients with OSAHS; however, some patients may require orthognathic surgery.
https://ift.tt/2yvPprb
Intraoperative comparison of single- and double-puncture techniques in temporomandibular joint arthrocentesis
Publication date: August 2018
Source:International Journal of Oral and Maxillofacial Surgery, Volume 47, Issue 8
Author(s): M.F. Şentürk, T. Yazıcı, Y. Fındık, T. Baykul
The objective of this study was to compare techniques for temporomandibular joint (TMJ) arthrocentesis intraoperatively and to determine the ease of performance of these techniques for the physician. A total of 33 TMJ treatments were done using single-puncture arthrocentesis (SPA) type 1, SPA type 2, and double-puncture arthrocentesis (DPA) (n=11 in each treatment group) between December 2013 and December 2017. A retrospective analysis of the duration of the procedure (minutes), occurrence of complications, number of cannula relocations, and ease of the procedure was performed. Ease of the procedure was measured using a Likert-type visual analogue scale (VAS; 0–10). All measurement variables were recorded intraoperatively, and related data were analyzed statistically. Significant differences were found between SPA type 2 and the other techniques in terms of procedure duration and ease of the procedure (P<0.05). No significant differences were found in the occurrence of complications or number of cannula relocations between the techniques (P>0.05). Compared to the other TMJ arthrocentesis techniques, SPA type 2 is easier, and physicians can perform it in a shorter time.
https://ift.tt/2lq0Qat
Tethering technique using bone screws and wire for chronic mandibular dislocation: a preliminary study of refractory cases
Publication date: August 2018
Source:International Journal of Oral and Maxillofacial Surgery, Volume 47, Issue 8
Author(s): N. Segami, T. Nishimura, K. Miyaki, H. Adachi
A retrospective study was performed to determine the efficacy of a tethering procedure developed to achieve a more rigid fixation and more reliable outcome in patients with refractory dislocation of the temporomandibular joint. The cases of eight patients with dementia and systemic diseases who underwent this technique were reviewed. In these eight patients, the condyles of 13 joints were ligated using wire between screws placed in the eminence and condylar head. Additional screw–wire ligations were applied to reinforce the restraint of movement in five of the 13 joints with suspected uncontrolled dislocation. The procedure was performed successfully, and the patients were followed-up for an average of 25months. In one patient, dislocation recurred 1year postoperatively due to wire breakage. The five joints in which a double set of screw–wire tethering was applied showed no recurrence or wire disturbance. This technique may, therefore, have short-term efficacy in cases that are refractory to standard procedures, although the material used for ligation should be investigated further. This approach can contribute to the quality of life of patients, particularly those with a short life-expectancy.
https://ift.tt/2yF13zQ
Immediate function dental implants inserted with less than 30N·cm of torque in full-arch maxillary rehabilitations using the All-on-4 concept: retrospective study
Publication date: August 2018
Source:International Journal of Oral and Maxillofacial Surgery, Volume 47, Issue 8
Author(s): P. Maló, A. Lopes, M. de Araújo Nobre, A. Ferro
The aim of this retrospective clinical study was to evaluate the short-term implant success rate and marginal bone loss in full-arch fixed prosthetic maxillary rehabilitations supported by implants in immediate function with the All-on-4 treatment concept placed with insertion torque of <30N·cm or ≥30N·cm. This study included 83 patients (69 female, 14 male) with 332 implants placed (120 inserted with <30N·cm and 212 inserted with ≥30N·cm) who were treated between January 2010 and March 2013. Outcome measures were implant success and marginal bone loss at 1year of follow-up. Ten patients (12.0%; 13 implants inserted with <30N·cm and 27 implants with ≥30N·cm) were lost to follow-up. The cumulative implant success rate was 97.5% at the patient level, and 98.3% for implants inserted with <30N·cm and 97.5% for implants inserted with ≥30N·cm. The mean±standard deviation marginal bone loss at 1year was 1.14±0.38mm for implants inserted with <30N·cm and 1.39±0.49mm for implants inserted with ≥30N·cm (significant difference; P<0.001, Wilcoxon signed rank test). These results indicate that implants with insertion torques of <30N·cm may render comparable success rates and marginal bone loss at 1year compared to implants inserted with insertion torques of ≥30N·cm.
https://ift.tt/2lrefip
Synergistic Cytokine Effects as Apremilast Response Predictors in Patients With Psoriasis
Publication date: Available online 21 June 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Sandra Garcet, Kristine Nograles, Joel Correa da Rosa, Peter H. Schafer, James G. Krueger
•Based on nonlinear multivariate algorithms, IL-17F is the most important predictor of PASI improvement with apremilast, and nonlinear synergistic cytokine effects are more predictive of PASI response to apremilast than linear univariate models.
https://ift.tt/2Ijfx8b
Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation
Source:Journal of Allergy and Clinical Immunology
Author(s): Helen Cao, Mark Biondo, Hadi Lioe, Samantha Busfield, Veronika Rayzman, Bernhard Nieswandt, Konrad Bork, Leonard C. Harrison, Priscilla Auyeung, Henriette Farkas, Dorottya Csuka, Matthias Pelzing, Steve Dower, Michael J. Wilson, Andrew Nash, Marc W. Nolte, Con Panousis
Teaser
HAE results in swelling due to KKS dysregulation and bradykinin production. FXII initiates the KKS and we have developed a human antibody that potently inhibits FXII protease activity as a novel prophylactic therapy for HAE.https://ift.tt/2Kf2Pwh
Disrupted N-linked glycosylation as a disease mechanism in deficiency of ADA2
Publication date: Available online 21 June 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Pui Y. Lee, Yuelong Huang, Qing Zhou, Oskar Schnappauf, Michael S. Hershfield, Ying Li, Nancy J. Ganson, Natalia Sampaio Moura, Ottavia M. Delmonte, Scellig S. Stone, Michael J. Rivkin, Sung-Yun Pai, Todd Lyons, Robert P. Sundel, Victor W. Hsu, Luigi D. Notarangelo, Ivona Aksentijevich, Peter A. Nigrovic
Deficiency of adenosine deaminase 2 is characterized by vasculitis, early-onset strokes, immunodeficiency, and bone marrow failure. We describe a novel pathogenic mutation affecting a consensus N-linked glycosylation sequence and illustrate the essential role of glycosylation in the biology of ADA2.
https://ift.tt/2MgUsxE
Vitamin D Supplementation Attenuates Asthma Development Following Traffic-Related Particulate Matter Exposure
Publication date: Available online 21 June 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Paige Bolcas, Eric Brandt, Zhonghua Zhang, Jocelyn Biagini Myers, Brandy Ruff, Gurjit K. Khurana Hershey
BackgroundRecent literature suggests that children who are vitamin D deficient are uniquely susceptible to the effects of traffic-related air pollution (TRAP) exposure. This is highly significant because large segments of the population reside in zones of high TRAP exposure.ObjectiveTo determine whether vitamin D supplementation mitigates the impact of TRAP exposure on asthma development, asthma exacerbation, and/or airway inflammation, and to determine the timing of vitamin D supplementation that confers maximal health benefit.MethodsUsing established mouse models of asthma, we examined the impact of pre-and post-natal vitamin D supplementation on asthma development as well as the utility of vitamin D as a treatment for established asthma in the context of diesel-exhaust particle (DEP) exposure.ResultsDEP and allergen co-exposure resulted in increased airway hyperresponsiveness (AHR) and accumulation of pathogenic Th2/Th17 cells in the lungs of vitamin D deficient mice compared to control mice. Prenatal and postnatal vitamin D supplementation significantly attenuated the development of AHR, and decreased pulmonary accumulation of Th2/Th17 cells following co-exposure to TRAP and allergen, but not allergen alone. Restoration of normal vitamin D status had no impact on AHR once asthma was already established.ConclusionsOur data establish that vitamin D confers protection against asthma development specifically in the context of TRAP exposure. While vitamin D replacement did not reverse established asthma, restoration of normal vitamin D status in early life significantly attenuated the development of AHR in DEP-exacerbated allergic asthma and reduced lung Th2/Th17 cells, which portend the development of severe asthma.Clinical ImplicationsEarly vitamin D supplementation may be an effective preventive strategy for the development of TRAP-induced asthma.
Graphical abstract
Teaser
The authors show that restoration of normal vitamin D status in early life attenuates the development of allergic asthma in mice exposed to traffic-related diesel exhaust particles (DEPs).https://ift.tt/2K1u91F
Questioning the accuracy of currently available pneumococcal antibody testing
Source:Journal of Allergy and Clinical Immunology
Author(s): Joud Hajjar, Aba Al-Kaabi, Carleigh Kutac, James Dunn, William T. Shearer, Jordan S. Orange
Teaser
Clinically significant inter-laboratory differences in Streptococcus pneumoniae antibodies were identified between commercial laboratories. These differences could affect diagnoses and management when assessing humoral deficiencies; thus, commercial laboratory methods should be standardized to obtain similar results.https://ift.tt/2MdgjpM
Eosinophil degranulation products drive a pro-inflammatory fibroblast phenotype
Source:Journal of Allergy and Clinical Immunology
Author(s): Ksenija Bernau, Jonathan P. Leet, Stephane Esnault, Andrea L. Noll, Michael D. Evans, Nizar N. Jarjour, Nathan Sandbo
Teaser
In this study, we found that eosinophil-derived degranulation products stimulate bronchial fibroblasts to release chemotactic factors that promote neutrophil migration. This finding suggests that eosinophil-fibroblast interactions may promote airway neutrophilia in severe asthma.https://ift.tt/2K0xRZy
Retraction Note to: Monitoring of vecuronium-induced neuromuscular block at the sternocleidomastoid muscle in anesthetized patients
The Editor-in-Chief has retracted this article [1] because the three studies included in the meta-analysis [2,3 and 4] (cited as references 16, 17 and 18) have been retracted due to concerns regarding the data, which has rendered the results of this meta-analysis invalid.
https://ift.tt/2K0Pdpj
Immediate versus delayed reconstruction of head and neck cutaneous melanoma
The Laryngoscope, EarlyView.
https://ift.tt/2tvjMIq
Diagnosing nontuberculous mycobacterial cervicofacial lymphadenitis in children: A systematic review
Publication date: September 2018
Source:International Journal of Pediatric Otorhinolaryngology, Volume 112
Author(s): S.H. Willemse, M.A.E.M. Oomens, J. De Lange, L.H.E. Karssemakers
ObjectivesWidespread controversy exists regarding correct diagnosing nontuberculous mycobacterial cervicofacial (NTM) lymphadenitis. This study intends to gather the available evidence with respect to diagnosing NTM cervicofacial lymphadenitis.MethodsA review protocol was developed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA)-statement (https://ift.tt/16KM5lR). A comprehensive search was performed in the bibliographic databases PubMed, Embase.com and Wiley/Cochrane Library. 10 Articles fulfilled the inclusion criteria and were included in the review. Assessing risk of bias of the articles was done using the revised Quality Assessment of Diagnostic Accuracy (QUADAS-2) tool.ResultsThis systematic review shows that diagnostic studies of high methodological quality are scarce. Diagnostic accuracy of polymerase chain reaction (PCR), culture, skin testing, auramine staining, Ziehl-Neelsen staining, and immunodiagnostic assays was studied. Culture sensitivity proved to be 41,8%, while polymerase chain reaction has a sensitivity of 71,6%. Both methods showed a specificity of 100%. Sensitivity of Immunodiagnostic assays ranged between 87,5% and 100% and specificity between 81% and 100%. Overall sensitivity of skin tests containing purified protein derivative (PPD-S) was 70% (95% CI [62%–78%]) with an overall specificity of 94% (95% CI [88%–100%]).ConclusionsIn patients with a high clinical suspicion for NTM cervicofacial lymphadenitis, a positive PPD-S skin is indicative for the diagnosis of NTM cervicofacial lymphadenitis. Either PCR or culture is necessary to confirm the diagnosis. Interferon-γ release assays with purified protein derivative stimulation appear to provide good sensitivity and specificity as a non-invasive pre-operative test, but the evidence is weak. More studies of high methodological quality are needed to validate the results of this systematic review.
https://ift.tt/2MNCow4
Spontaneous hair regrowth in eight patients with severe alopecia areata
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2yxon2D
Transoral Robotic Surgery: Image Guidance and Augmented Reality
ORL
https://ift.tt/2yE9mMG
Transoral Robotic Surgery for Obstructive Sleep Apnoea-Hypopnoea Syndrome
ORL
https://ift.tt/2ls4roB
High‐risk human papillomavirus in a child with digital pigmented Bowen's disease: Case report and dermoscopic findings
Pediatric Dermatology, EarlyView.
https://ift.tt/2tvjyRs
Proportionate growth of congenital nevi: Blow a balloon to explain
Pediatric Dermatology, EarlyView.
https://ift.tt/2MOVHVN
Involvement of CD8+ T cell subsets in early response to vascular injury in patients with peripheral arterial disease in vivo
Source:Clinical Immunology
Author(s): Pawel Maga, Tomasz P. Mikolajczyk, Lukasz Partyka, Mateusz Siedlinski, Mikolaj Maga, Marek Krzanowski, Krzysztof Malinowski, Kevin Luc, Rafal Nizankowski, Deepak L. Bhatt, Tomasz J. Guzik
AimsAdaptive immunity is critical in vascular remodelling following arterial injury. We hypothesized that acute changes in T cells at a percutaneous transluminal angioplasty (PTA) site could serve as an index of their potential interaction with the injured vascular wall.Methods and ResultsT cell subsets were characterised in 45 patients with Rutherford 3–4 peripheral arterial disease (PAD) undergoing PTA. Direct angioplasty catheter blood sampling was performed before and immediately after the procedure. PTA was associated with an acute reduction of α/β-TcR CD8+ T cells. Further characterisation revealed significant reduction in pro-atherosclerotic CD28nullCD57+ cells, effector and effector memory cells, in addition to cells bearing activation and tissue homing/adhesion markers.ConclusionsThe acute reduction observed here is likely due to the adhesion of cells to the injured vascular wall, suggesting that immunosenescent, activated effector CD8+ cells have a role in the early vascular injury immune response following PTA in PAD patients.
https://ift.tt/2JYa649
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