A phase IIb randomized, double-blind, placebo-controlled trial of ubrogepant for the acute treatment of migraine
Aim The aim of this trial was to evaluate the efficacy and tolerability of ubrogepant (MK-1602), a calcitonin gene-related peptide receptor antagonist (CGRP-RA), for the acute treatment of migraine. Methods This double-blind, placebo-controlled study randomized 834 participants to treat one migraine attack with ubrogepant 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, or placebo in a 1:1 ratio. The co-primary endpoints were pain freedom and headache response at two hours. The first primary hypothesis tested the dose-response trend for two-hour pain freedom using a logistic regression model... περισσότερα »
Frontalis Sling for the Treatment of Congenital Ptosis
In this case, the frontalis sling procedure was used to correct congenital ptosis of the right upper eyelid. *ePlasty, Open Access Journal of Plastic Surgery* from #ENT via xlomafota13 on Inoreader http://ift.tt/1PCJVgL via IFTTT
Ceramic variation and negotiated communities in the Late Valdivia phase of coastal Ecuador
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Publication date: September 2016 Source:Journal of Anthropological Archaeology, Volume 43 Author(s): Sarah M. Rowe Previous research of prehispanic coastal Ecuador has argued for the development of social hierarchies during the Late Valdivia period (2400–1800 BCE), based on changing regional settlement patterns, increased long-distance exchange, and increasing intra-site differentiation. Recent investigations at Valdivia sites have highlighted […]
Electronic nicotine delivery system landscape in licensed tobacco retailers: results of a county-level survey in Oklahoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Objectives Electronic nicotine delivery systems (ENDS) have recently emerged as a component of the tobacco retail environment. The aims of this study were to describe the availability, types of ENDS and placement of ENDS relative to traditional tobacco products at franchised licensed tobacco retailers and non-franchised licensed tobacco retailers. Design Observational study. Setting Franchised and […]
Validation of the Kinyarwanda-version Short-Form Leeds Dyspepsia Questionnaire and Short-Form Nepean Dyspepsia Index to assess dyspepsia prevalence and quality-of-life impact in Rwanda
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Objectives We aimed to develop and validate Kinyarwanda versions of Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ) and Short-Form Nepean Dyspepsia Index (SF-NDI) to measure the frequency and severity of dyspepsia and associated quality-of-life impact in Rwanda. Setting A single, tertiary care centre in Rwanda. Participants 200 consecutive Kinyarwanda-speaking patients referred to endoscopy (100 patients) or medical […]
Default options in advance directives: study protocol for a randomised clinical trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Introduction Although most seriously ill Americans wish to avoid burdensome and aggressive care at the end of life, such care is often provided unless patients or family members specifically request otherwise. Advance directives (ADs) were created to provide opportunities to set limits on aggressive care near life’s end. This study tests the hypothesis that redesigning […]
Identifying improvements to complex pathways: evidence synthesis and stakeholder engagement in infant congenital heart disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Objectives Many infants die in the year following discharge from hospital after surgical or catheter intervention for congenital heart disease (3–5% of discharged infants). There is considerable variability in the provision of care and support in this period, and some families experience barriers to care. We aimed to identify ways to improve discharge and postdischarge […]
When procedures meet practice in community pharmacies: qualitative insights from pharmacists and pharmacy support staff
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Objectives Our aim was to explore how members of community pharmacy staff perceive and experience the role of procedures within the workplace in community pharmacies. Setting Community pharmacies in England and Wales. Participants 24 community pharmacy staff including pharmacists and pharmacy support staff were interviewed regarding their view of procedures in community pharmacy. Transcripts were […]
Clinical outcomes at 12 months and risk of inflammatory bowel disease in patients with an intermediate raised fecal calprotectin: a ‘real-world view
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Objectives A recent systematic review confirmed the usefulness of fecal calprotectin (FC) in distinguishing organic (inflammatory bowel disease (IBD)) from non-organic gastrointestinal disease (irritable bowel syndrome (IBS)). FC levels <50 μg/g have a negative predictive value >92% to exclude organic gastrointestinal (GI) disease. Levels >250 μg/g correlate with endoscopic IBD disease activity; sensitivity 90%. We […]
Comparing cognitive-behavioural psychotherapy and psychoeducation for non-specific symptoms associated with indoor air: a randomised control trial protocol
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Introduction Indoor air-related conditions share similarities with other conditions that are characterised by medically unexplained symptoms (MUS)-a combination of non-specific symptoms that cannot be fully explained by structural bodily pathology. In cases of indoor air-related conditions, these symptoms are not fully explained by either medical conditions or the immunological–toxicological effects of environmental factors. The condition […]
Longitudinal trends in use and costs of targeted therapies for common cancers in Taiwan: a retrospective observational study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Objectives Some targeted therapies have improved survival and overall quality of cancer care generally, but these increasingly expensive medicines have led to increases in pharmaceutical expenditure. This study examined trends in use and expenditures of antineoplastic agents in Taiwan, and estimated market shares by prescription volume and costs of targeted therapies over time. We also […]
Effect of affordable technology on physical activity levels and mobility outcomes in rehabilitation: a protocol for the Activity and MObility UsiNg Technology (AMOUNT) rehabilitation trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Introduction People with mobility limitations can benefit from rehabilitation programmes that provide a high dose of exercise. However, since providing a high dose of exercise is logistically challenging and resource-intensive, people in rehabilitation spend most of the day inactive. This trial aims to evaluate the effect of the addition of affordable technology to usual care […]
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Radioactive Iodine Treatment Is Associated with Improved Survival for Patients with Hürthle Cell Carcinoma
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Thyroid Cancer–Specific Quality of Life and Health-Related Quality of Life in Young Adult Thyroid Cancer Survivors
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Prognostic Significance of TERT Promoter Mutations in Papillary Thyroid Carcinomas in a BRAFV600E Mutation–Prevalent Population
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A chilling reminder: Pediatric facial trauma from recreational winter activities
Publication date: August 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 87 Author(s): Peter F. Svider, Michael Bobian, Houmehr Hojjat, Anthony Sheyn, Giancarlo Zuliani, Jean Anderson Eloy, Adam J. Folbe BackgroundWinter activities offer children and adolescents an outdoor recreational opportunity during the coldest months. Our objectives were to estimate the national incidence of facial injury associated with recreational winter activities. Furthermore, we analyze demographic trends and clinical characteristics of patients presenting to emergency depart... περισσότερα »
Sitting 3-D CT in Patients With Patulous Eustachian Tube.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 20 δευτερόλεπτα
Relationship Between Clinical Test Results and Morphologic Severity Demonstrated by Sitting 3-D CT in Patients With Patulous Eustachian Tube.: Objective: To investigate the correlation of sitting 3-D computed tomography (CT) scans of the Eustachian tube (ET) with subjective and objective findings in patients with patulous Eustachian tube (PET). Study Design: Retrospective. Setting: Tertiary referral center. […]
mri Compatibility of a New Generation of Active Middle Ear Implant
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 20 δευτερόλεπτα
Magnetic Resonance Imaging Compatibility of a New Generation of Active Middle Ear Implant: A Clinically Relevant Temporal Bone Laboratory Study.: Objective: Magnetic resonance imaging (MRI) has become an essential tool of modern medical imaging and disease diagnosis. In November 2014, a new MRI-conditional (up to 1.5 T) generation of an active middle ear implant (AMEI) […]
Surgical resection of extensive cholesteatoma with medial involvement of the vertical segment of the facial nerve resulted in an unsupported mastoid segment
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 20 δευτερόλεπτα
The Tightrope Facial Nerve-An Unsupported Mastoid Segment After Resection of Recidivistic Cholesteatoma.: Objectives/Hypothesis: Cholesteatomas are epidermal inclusion cysts containing stratified squamous epithelium that arise in the middle ear and mastoid cavities resulting in a persistent inflammatory state. Complications include chronic otorrhea, granulation tissue, and bony erosion. Cholesteatoma growth patterns predict frequent involvement of the Fallopian […]
Anatomy Pathology 36 Unread articles
SEARCHBreast: An online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals Valerie Speirs, Bethny Morrisey, Ingunn Holen, Karen Blyth, Phil Carter, Claude Chelala, Louise Jones · Monday, June 06, 2016, 15:55 Tags: Anatomy Pathology - - - - - Der Pathologe Mitteileungen Bundesverband Deutscher Pathologen Saturday, June 04, 2016, 15:23 Tags: Anatomy Pathology - - - - - Der Pathologe Mitteilungen der ÖGPath/IAP Austria Saturday, June 04, 2016, 15:23 Tags: Anatomy Pathology - - ... περισσότερα »
Anatomy Pathology 38 Unread articles
Well-Differentiated Liposarcoma With Hibernoma-Like Morphology Hallin, M., Schneider, N., Thway, K. · Tuesday, June 07, 2016, 7:54 Well-differentiated liposarcoma (WDL) can show a morphologic spectrum, including lipoma-like, sclerosing and inflammatory subtypes. It does not metastasize but can dedifferentiate, acquiring metastatic potential. Hibernomas are benign neoplasms that show variable differentiation toward brown fat, and can sometimes occur in the abdomen or retroperitoneum. We illustrate a case of retroperitoneal WDL that showed extensive hibernoma-like morphology, with shee... περισσότερα »
Physiology 41 Unread articles
Melatonin Inhibits CXCL10 and MMP-1 Production in IL-1β-Stimulated Human Periodontal Ligament Cells Monday, June 06, 2016, 23:55 Abstract Melatonin is a hormone that is mainly secreted by the pineal gland and exhibits a wide spectrum of activities, including antioxidant functions. Melatonin has been detected in gingival crevicular fluid. However, the role of melatonin in periodontal tissue is still uncertain. The aim of this study was to examine the effects of melatonin on inflammatory mediator expression in human periodontal ligament cells (HPDLC). Interleukin (IL)-1β induced CXC c... περισσότερα »
Dental Prosthesis for a Young Cleft Lip and Palate Patient
Modified PEEK Resin Bonded Fixed Dental Prosthesis for a Young Cleft Lip and Palate Patient: Abstract Objective This clinical report presents the use of a modified poly ether–ether ketone material as an alternative material for the fabrication of resin-bonded fixed dental prosthesis (RBFDP) framework. This new material can be used for patients allergic to metals, maintaining the same high esthetic demand of ceramics, presenting light weightness and a flexibility similar to bone as a distinct advantage over ceramic materials. Conclusions The use of a BioHPP RBFDP framework could be c... περισσότερα »
How the demographic makeup of our community influences speech perception
How the demographic makeup of our community influences speech perception: [image: cm_sbs_024_plain.png] Speech perception is known to be influenced by listeners' expectations of the speaker. This paper tests whether the demographic makeup of individuals' communities can influence their perception of foreign sounds by influencing their expectations of the language. Using online experiments with participants from all across the U.S. and matched census data on the proportion of Spanish and other foreign language speakers in participants' communities, this paper shows that the demograp... περισσότερα »
Gait & Posture : Children with cerebral palsy
experience greater levels of loading at the low back during gait compared to healthy controls” via Gait & Posture Publication date: Available online 6 June 2016 *Source:*Gait & Posture Author(s): D. Kiernan, A. Malone, T. O’Brien, C.K. Simms Excessive trunk motion has been shown to be characteristic of cerebral palsy (CP) gait. However, the associated demands on the lower spine are unknown. This study investigated 3-dimensional reactive forces and moments at the low back in CP children compared to healthy controls. In addition, the impact of functional level of impairment was investi... περισσότερα »
Secondary Acquired Cholesteatoma
Presentation and Tympanoplasty Outcomes.: Objective: Comparing the clinical features and surgical outcomes of patients undergoing tympanoplasty for secondary acquired cholesteatoma (SAC) versus non-complicated tympanic membrane perforation (TMP). Study Design: Retrospective patient review. Setting: Tertiary-care, academic center. Patients: All 41 patients with diagnosis of SAC confirmed at surgery between January 1, 2007 and June 30, 2014, and an age-matched cohort consisting of patients with TMP. Intervention(s): Tympanoplasty using either medial or lateral graft techniques. Ma... περισσότερα »
The Pars Inferior of the Human Inner Ear : Focal Endolymphatic Hydrops
Focal Endolymphatic Hydrops as Seen in the Pars Inferior of the Human Inner Ear.: Hypothesis: Endolymphatic hydrops of the human inner ear may be localized focally in the pars inferior of the human inner ear. Background: Endolymphatic hydrops may be found in the human inner ear in patients who in life had suffered from Meniere's syndrome or a variety of other disorders. The degree of endolymphatic hydrops may differ based on location in the inner ear. Methods: A computer-assisted search of all cases in the collection of the Massachusetts Eye and Ear Infirmary in which endolymphatic ... περισσότερα »
The Pars Inferior of the Human Inner Ear
Focal Endolymphatic Hydrops as Seen in the Pars Inferior of the Human Inner Ear.: Hypothesis: Endolymphatic hydrops of the human inner ear may be localized focally in the pars inferior of the human inner ear. Background: Endolymphatic hydrops may be found in the human inner ear in patients who in life had suffered from Meniere's syndrome or a variety of other disorders. The degree of endolymphatic hydrops may differ based on location in the inner ear. Methods: A computer-assisted search of all cases in the collection of the Massachusetts Eye and Ear Infirmary in which endolymphatic ... περισσότερα »
Cochlear Implantation in Schwannomas
Cochlear Implantation in Patients With Intracochlear and Intralabyrinthine Schwannomas.: Objective: Schwannomas may arise primarily within the inner ear, or invade the cochlea or labyrinth from the distal internal auditory canal through transmodiolar or transmacular extension, respectively. To date, very limited data exists regarding cochlear implant (CI) outcomes in this unique population. Study Design: Retrospective case review. Patients: Ten ears (nine patients) with inner ear schwannomas that underwent CI at a single tertiary referral center. Intervention(s): Cochlear implantat... περισσότερα »
Cochlear Histopathology
as Observed in Two Patients With a Cochlear Implant Electrode With Positioner.: Hypothesis: This study reports the cochlear histopathology of two patients who during life underwent cochlear implantation with a positioner. Background: A silastic positioner introduced by the Advanced Bionics Corporation in 1999 was designed to position the electrode of the cochlear implant close to the modiolus. The positioner was recalled in the United States in July 2002 because of an apparent higher incidence of bacterial meningitis in patients in whom the positioner had been placed. Methods: Fou... περισσότερα »
Type I Tympanoplasty
Meta-Analysis: A Single Variable Analysis.: Objective: To determine which independent variables influencing the efficacy of type I tympanoplasty in adult and pediatric populations. Data Sources: A search of the PubMed database and Cochrane Database of Systematic Reviews using the key words "tympanoplasty OR myringoplasty" from January 1966 to July 2014 was performed. Study Selection: Studies reporting outcomes of myringoplasty or Type I tympanoplasty in primary non-cholesteatomatous chronic tympanic membrane (TM) perforation were included. Data Extraction: Of 4,698 abstracts revie... περισσότερα »
TeleAudiology
in the Veterans Health Administration.: Objective: To assess effectiveness of TeleAudiology for hearing aid services. Study Design: Retrospective case-control. Setting: Ambulatory Veterans Health Administration and Community-Based Outpatient Clinics (CBOCs). Patients: 42,697 veterans who received hearing aids from January through September, 2014. Intervention(s): TeleAudiology (TA) and conventional in-person (IP) audiology care. Main Outcome Measure(s): International Outcome Inventory for Hearing Aids (IOI-HA) outcomes data. The IOI-HA is a 7-item survey used to assess hearing a... περισσότερα »
Petroclival Chondrosarcoma
A Multicenter Review of 55 Cases and New Staging System.: Objective: To analyze clinical outcomes after treatment of petroclival chondrosarcoma and to propose a novel staging system. Study Design: Retrospective case review, 1995 to 2015. Setting: Multicenter study. Patients: Consecutive patients with histopathologically proven petroclival chondrosarcoma. Intervention(s): Microsurgery, endoscopic endonasal surgery, radiation therapy, observation. Main Outcome Measures: Disease- and treatment-associated morbidity, recurrence, mortality. Results: Fifty-five patients (mean age 42 ye... περισσότερα »
Tissue Preservation Surgical Techniques in Percutaneous Bone Conduction Hearing Devices.
A Systematic Review on Complications of Tissue Preservation Surgical Techniques in Percutaneous Bone Conduction Hearing Devices.: Objective: To investigate skin-related postoperative complications from tissue preservation approaches in percutaneous bone conduction device (BCD) implantations. Data Sources: PubMed, Embase, and Cochrane Library. Study Selection: We identified studies on BCDs including the opted surgical technique and derived complications. Retrieved articles were screened using predefined inclusion criteria. Critical appraisal included directness of evidence and risk ... περισσότερα »
Botulinum Toxin Treatment of Objective Tinnitus
Botulinum Toxin Treatment of Objective Tinnitus Because of Essential Palatal Tremor: A Systematic Review.: Introduction: In contrast to subjective tinnitus, objective tinnitus can be heard by the examiner as well as by the patient. It can be triggered by, among many other etiologies, idiopathic muscular tremor in the soft palate, the essential palatal tremor (EPT). Many treatment modalities have been investigated, of which only Botulinum toxin (BT) injections have shown promising results. Goal: The aim of this study was to evaluate the effect of BT treatment on objective tinnitus du... περισσότερα »
Botulinum Toxin Treatment of Essential Palatal Tremor
Botulinum Toxin Treatment of Objective Tinnitus Because of Essential Palatal Tremor: A Systematic Review.: Introduction: In contrast to subjective tinnitus, objective tinnitus can be heard by the examiner as well as by the patient. It can be triggered by, among many other etiologies, idiopathic muscular tremor in the soft palate, the essential palatal tremor (EPT). Many treatment modalities have been investigated, of which only Botulinum toxin (BT) injections have shown promising results. Goal: The aim of this study was to evaluate the effect of BT treatment on objective tinnitus du... περισσότερα »
Ossiculoplasty Outcomes and Complications
The Association of Valsalva Status With Smoking and Its Impact on Ossiculoplasty Outcomes and Complications.: Objectives: To assess the association of a patient's ability to perform a clinically observed Valsalva maneuver with tobacco smoking and post-ossiculoplasty outcomes. Study Design: Case series with chart review. Setting: Tertiary referral, university-based otology practice. Patients: Adult patients (16-88 years of age) undergoing ossiculoplasty with tympanoplasty or tympanomastoidectomy using cartilage tympanic membrane grafts, retrograde mastoidectomy with canal wall recons... περισσότερα »
Asymmetrical hearing loss accounted for between 2.4% and 22.6% of NIHL cases (L-R difference >15 dB for any frequency 0.5-8 kHz)
Asymmetrical Hearing Loss in Cases of Industrial Noise Exposure: A Systematic Review of the Literature.: Objective: Asymmetrical hearing thresholds are common in people claiming compensation for noise-induced hearing loss (NIHL). When present and otherwise unexplained, there is some controversy as to whether such asymmetry can be attributed to occupational noise exposure. In this review, our main objectives were to collate the overall prevalence of this finding in subjects with NIHL, and further, to provide a balanced argument regarding causality. Data Sources: MEDLINE, CINAHL, EMBA... περισσότερα »
Primary Epidermoid Tumors of the Cerebellopontine Angle
A Review of 47 Cases.: Objective: To analyze disease presentation, treatment, and clinical course of a consecutive series of patients with primary cerebellopontine angle (CPA) epidermoids. Patients: Forty-seven consecutive patients with previously untreated CPA epidermoids. Intervention(s): Observation and microsurgery. Main Outcome Measures: Disease- and treatment-associated morbidity, recurrence. Results: Forty-seven patients (mean age 39 years; 53% women) were analyzed and the average duration of follow-up was 42 months. The most common presenting symptom was headache (27; 57%)... περισσότερα »
Sitting 3-D CT in Patients With Patulous Eustachian Tube.
Relationship Between Clinical Test Results and Morphologic Severity Demonstrated by Sitting 3-D CT in Patients With Patulous Eustachian Tube.: Objective: To investigate the correlation of sitting 3-D computed tomography (CT) scans of the Eustachian tube (ET) with subjective and objective findings in patients with patulous Eustachian tube (PET). Study Design: Retrospective. Setting: Tertiary referral center. Subjects: A retrospective survey of medical records in Sen-En Hospital identified 40 patients and 62 ears with PET between September 2014 and June 2015. Method: Diagnosis of PE... περισσότερα »
mri Compatibility of a New Generation of Active Middle Ear Implant
Magnetic Resonance Imaging Compatibility of a New Generation of Active Middle Ear Implant: A Clinically Relevant Temporal Bone Laboratory Study.: Objective: Magnetic resonance imaging (MRI) has become an essential tool of modern medical imaging and disease diagnosis. In November 2014, a new MRI-conditional (up to 1.5 T) generation of an active middle ear implant (AMEI) was released to the market. The aim of the study was to test the MRI compatibility of the new implant system in a clinical-anatomical study. Design: Experimental cadaver head model. Setting: Temporal bone laboratory.... περισσότερα »
Surgical resection of extensive cholesteatoma with medial involvement of the vertical segment of the facial nerve resulted in an unsupported mastoid segment
The Tightrope Facial Nerve-An Unsupported Mastoid Segment After Resection of Recidivistic Cholesteatoma.: Objectives/Hypothesis: Cholesteatomas are epidermal inclusion cysts containing stratified squamous epithelium that arise in the middle ear and mastoid cavities resulting in a persistent inflammatory state. Complications include chronic otorrhea, granulation tissue, and bony erosion. Cholesteatoma growth patterns predict frequent involvement of the Fallopian canal of the facial nerve. Extensive disease may extend to the posterior and middle fossa dura, the otic capsule, the carot... περισσότερα »
Flat-Panel CT Imaging for Individualized Pitch Mapping
in Cochlear Implant Users.: Objective: This study aims to identify electrode contact location and to assess frequency deviation between predicted and actual frequency allocation maps in cochlear implant (CI) users. Study Design and Methods: This is a retrospective clinical study. Flat-panel computed tomography (FPCT) scans were collected for 17 CI users. Cochlear length was measured using three-dimensional curved multiplanar reconstruction on high-resolution secondary reconstructions. Each electrode's percentage of distance from the base of the helicotrema was measured, and a modi... περισσότερα »
Ossiculoplasty
The Impact of Smoking on Ossiculoplasty Outcomes.: Objectives: To assess the impact of tobacco smoking on outcomes after ossiculoplasty. Study Design: Case series with chart review. Setting: Tertiary care center. Patients: Adult patients (16-88 yr of age) undergoing ossiculoplasty with cartilage tympanoplasty. Outcome Measures: Patients were classified as smokers (TOB+) or nonsmokers (TOBN). Comparisons were then made between these two groups with regard to early and late audiometric outcomes, rate of cure of conductive hearing loss, rate of successful graft healing, and incidence ... περισσότερα »
ABI in Children with Severe Inner Ear Malformations.
Long-term Results of Objective: To report the long-term outcomes of children who received auditory brainstem implant (ABI) because of severe inner ear malformations. Study Design: Retrospective chart review. Setting: Tertiary referral otolaryngology clinic. Subjects and Methods: Between July 2006 and October 2014, 60 children received ABI at Hacettepe University. Preoperative work up included otolaryngologic examination, audiological assessment, radiological evaluation together with assessment of language development and psychological status. The surgeries were performed via retro... περισσότερα »
Auditory Brainstem Implantation in Neurofibromatosis Type II
Auditory Brainstem Implantation in Chinese Patients With Neurofibromatosis Type II: The Hong Kong Experience.: Objective: To describe our experience and outcomes of auditory brainstem implantation (ABI) in Chinese patients with Neurofibromatosis Type II (NF2). Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Patients with NF2 who received ABIs. Results: Between 1997 and 2014, eight patients with NF2 received 9 ABIs after translabyrinthine removal of their vestibular schwannomas. One patient did not have auditory response using the ABI after acti... περισσότερα »
Cancer
2h The Genomic Data Commons Launches Making genomic and clinical data about cancer accessible to the cancer research community is imperative for our success in applying precision medicine to clinical oncology. The NCI Genomic Data Commons (GDC), released today, brings us a step closer to realizing this goal.By analyzing large sets of shared... 2h Tumor Microenvironment Influences Metabolism of Cancer Cells When we think about tumor heterogeneity, we often imagine variation that originates from genetic and/or epigenetic mechanisms. However, there is increasing evidence that varia... περισσότερα »
Freehand three-dimensional ultrasound to assess semitendinosus muscle morphology
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
Abstract In several neurological disorders and muscle injuries, morphological changes of the m. semitendinosus (ST) are presumed to contribute to movement limitations around the knee. Freehand three-dimensional (3D) ultrasound (US), using position tracking of two-dimensional US images to reconstruct a 3D voxel array, can be used to assess muscle morphology in vivo. The aims of […]
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Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions
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Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?
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Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?
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Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions
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New concepts in HIV-1 vaccine development
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Auditory Brainstem Implantation in Chinese Patients With Neurofibromatosis Type II: The Hong Kong Experience.
Objective: To describe our experience and outcomes of auditory brainstem implantation (ABI) in Chinese patients with Neurofibromatosis Type II (NF2). Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Patients with NF2 who received ABIs. Results: Between 1997 and 2014, eight patients with NF2 received 9 ABIs after translabyrinthine removal of their vestibular schwannomas. One patient did not have auditory response using the ABI after activation. Environmental sounds could be differentiated by six (75%) patients after 6 months of ABI use (mean score... περισσότερα »
Long-term Results of ABI in Children with Severe Inner Ear Malformations.
Objective: To report the long-term outcomes of children who received auditory brainstem implant (ABI) because of severe inner ear malformations. Study Design: Retrospective chart review. Setting: Tertiary referral otolaryngology clinic. Subjects and Methods: Between July 2006 and October 2014, 60 children received ABI at Hacettepe University. Preoperative work up included otolaryngologic examination, audiological assessment, radiological evaluation together with assessment of language development and psychological status. The surgeries were performed via retrosigmoid approach with a... περισσότερα »
The Impact of Smoking on Ossiculoplasty Outcomes.
Objectives: To assess the impact of tobacco smoking on outcomes after ossiculoplasty. Study Design: Case series with chart review. Setting: Tertiary care center. Patients: Adult patients (16-88 yr of age) undergoing ossiculoplasty with cartilage tympanoplasty. Outcome Measures: Patients were classified as smokers (TOB+) or nonsmokers (TOBN). Comparisons were then made between these two groups with regard to early and late audiometric outcomes, rate of cure of conductive hearing loss, rate of successful graft healing, and incidence of complications after surgery. Results: There was n... περισσότερα »
Flat-Panel CT Imaging for Individualized Pitch Mapping in Cochlear Implant Users.
Objective: This study aims to identify electrode contact location and to assess frequency deviation between predicted and actual frequency allocation maps in cochlear implant (CI) users. Study Design and Methods: This is a retrospective clinical study. Flat-panel computed tomography (FPCT) scans were collected for 17 CI users. Cochlear length was measured using three-dimensional curved multiplanar reconstruction on high-resolution secondary reconstructions. Each electrode's percentage of distance from the base of the helicotrema was measured, and a modified Greenwood's function was ... περισσότερα »
Radioactive Iodine Treatment Is Associated with Improved Survival for Patients with Hürthle Cell Carcinoma
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Thyroid Cancer–Specific Quality of Life and Health-Related Quality of Life in Young Adult Thyroid Cancer Survivors
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Prognostic Significance of TERT Promoter Mutations in Papillary Thyroid Carcinomas in a BRAFV600E Mutation–Prevalent Population
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A chilling reminder: Pediatric facial trauma from recreational winter activities
Publication date: August 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 87 Author(s): Peter F. Svider, Michael Bobian, Houmehr Hojjat, Anthony Sheyn, Giancarlo Zuliani, Jean Anderson Eloy, Adam J. Folbe BackgroundWinter activities offer children and adolescents an outdoor recreational opportunity during the coldest months. Our objectives were to estimate the national incidence of facial injury associated with recreational winter activities. Furthermore, we analyze demographic trends and clinical characteristics of patients presenting to emergency depart... περισσότερα »
Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions
[image: S09527915.gif] Patricia T Illing | Nicole A Mifsud | Anthony W Purcell from #ENT via xlomafota13 on Inoreader http://ift.tt/1VJ2HEj via IFTTT
Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?
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New concepts in HIV-1 vaccine development
[image: S09527915.gif] Kathryn E Stephenson | Helen T D'Couto | Dan H Barouch from #ENT via xlomafota13 on Inoreader http://ift.tt/1TSJ47Y via IFTTT
Auditory Brainstem Implantation in Chinese Patients With Neurofibromatosis Type II: The Hong Kong Experience.
Objective: To describe our experience and outcomes of auditory brainstem implantation (ABI) in Chinese patients with Neurofibromatosis Type II (NF2). Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Patients with NF2 who received ABIs. Results: Between 1997 and 2014, eight patients with NF2 received 9 ABIs after translabyrinthine removal of their vestibular schwannomas. One patient did not have auditory response using the ABI after activation. Environmental sounds could be differentiated by six (75%) patients after 6 months of ABI use (mean score... περισσότερα »
The association of Red cell distribution width and in-hospital mortality in older adults admitted to the emergency department
The objective of the study was to test the hypothesis that elevated red cell distribution width (RDW) at admission increases the risk of mortality in older patients admitted to the emergency department (ED). from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1Xz7070
The association of Red cell distribution width and in-hospital mortality in older adults admitted to the emergency department
The objective of the study was to test the hypothesis that elevated red cell distribution width (RDW) at admission increases the risk of mortality in older patients admitted to the emergency department (ED). from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1Xz7070 via IFTTT
Rhizobium leguminosarum symbiovar trifolii, Ensifer numidicus, and Mesorhizobium amorphae symbiovar ciceri (or Mesorhizobium loti) are new endosymbiotic bacteria of Lens culinaris Medik
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
142 rhizobial bacteria were isolated from root nodules of Lens culinaris Medik endemic to Tunisia and they belonged to the species Rhizobium leguminosarum and for the first time to Ensifer and Mesorhizobium, genera never previously described as microsymbionts of lentil. Phenotypically, our results indicate that Lens culinaris Medik strains showed heterogenic responses to the different […]
Methane release from sediment seeps to the atmosphere is counteracted by highly active Methylococcaceae in the water column of deep oligotrophic Lake Constance
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Methane emissions from freshwater environments contribute substantially to global warming but are under strong control of aerobic methane-oxidizing bacteria. Recently discovered methane seeps (pockmarks) in freshwater lake sediments have the potential to bypass this control by their strong outgasing activity. Whether this is counteracted by pelagic methanotrophs is not well understood yet. We used a […]
Subalpine conifers in two different geographic locations host highly similar foliar bacterial endophyte communities.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Pines in the subalpine environment at Niwot Ridge, CO have been found to host communities of acetic acid bacteria (AAB) within their needles. The significance and ubiquity of this pattern is not known, but recent evidence of nitrogen (N)-fixing activity inside Pinus flexilis (limber pine) foliage calls for a better understanding of the processes that […]
Benthic protists: the under-charted majority
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Marine protist diversity inventories have largely focused on planktonic environments, while benthic protists have received relatively little attention. We therefore hypothesize that current diversity surveys have only skimmed the surface of protist diversity in marine sediments, which may harbour greater diversity than planktonic environments. We tested this by analyzing sequences of the hypervariable V4 18S […]
Reply: Perifascicular necrosis in anti-synthetase syndrome beyond anti-Jo-1
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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Perifascicular necrosis in anti-synthetase syndrome beyond anti-Jo-1
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Mutations in brain isoforms of voltage-gated sodium channels have been identified in patients with distinct epileptic phenotypes. Clinically, these patients often do not respond well to classic anti-epileptics and many remain refractory to treatment. Exogenous as well as endogenous cannabinoids have been shown to target voltage-gated sodium channels and cannabidiol has recently received attention for […]
Distinct Oral Neutrophil Subsets Define Health and Periodontal Disease States
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Neutrophils exit the vasculature and swarm to sites of inflammation and infection. However, these cells are abundant in the healthy, inflammation-free human oral environment, suggesting a unique immune surveillance role within the periodontium. We hypothesize that neutrophils in the healthy oral cavity occur in an intermediary parainflammatory state that allows them to interact with and […]
Well-Differentiated Liposarcoma With Hibernoma-Like Morphology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Well-differentiated liposarcoma (WDL) can show a morphologic spectrum, including lipoma-like, sclerosing and inflammatory subtypes. It does not metastasize but can dedifferentiate, acquiring metastatic potential. Hibernomas are benign neoplasms that show variable differentiation toward brown fat, and can sometimes occur in the abdomen or retroperitoneum. We illustrate a case of retroperitoneal WDL that showed extensive hibernoma-like […]
Evidence for a Notch1-mediated transition during olfactory ensheathing cell development
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Olfactory ensheathing cells (OECs) are a unique glial population found in both the peripheral and central nervous system: they ensheath bundles of unmyelinated olfactory axons from their peripheral origin in the olfactory epithelium to their central synaptic targets in the glomerular layer of the olfactory bulb. Like all other peripheral glia (Schwann cells, satellite […]
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«Music Therapy Helped Me Get Back Doing»: Perspectives of Music Therapy Participants in Mental Health Services
Background: Mental health service development internationally is increasingly informed by the collaborative ethos of recovery. Service user evaluation of experiences within music therapy programs allows new phenomena about participation in services to be revealed that might otherwise remain unnoticed. Objective: The aim of this study was to demonstrate how asking service users about their experience… Continue reading «Music Therapy Helped Me Get Back Doing»: Perspectives of Music Therapy Participants in Mental Health Services
Table of Contents
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Vocal Music Therapy for Chronic Pain Management in Inner-City African Americans: A Mixed Methods Feasibility Study
Background: To date, research on music for pain management has focused primarily on listening to prerecorded music for acute pain. Research is needed on the impact of active music therapy interventions on chronic pain management. Objective: The aim of this mixed methods research study was to determine feasibility and estimates of effect of vocal music… Continue reading Vocal Music Therapy for Chronic Pain Management in Inner-City African Americans: A Mixed Methods Feasibility Study
Obscure Retropharyngeal Mucocutaneous Masses Associated With Acoustic Neurofibromatosis: A Source of Difficult Airway Management.
No abstract available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1t3WkzR via IFTTT
The Power of Raw Data.
No abstract available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Yc3JJu via IFTTT
Cerebral Oxygenation Under General Anesthesia Can Be Safely Preserved in Patients in Prone Position: A Prospective Observational Study.
Background: The effects of prone position (PP) on cerebral tissue metabolism are not well known. The aim of this investigation was to evaluate regional cerebral oxygen desaturation in patients undergoing lumbar spine surgery in PP during routine anesthesia management. Materials and Methods: Between July 2013 and October 2013, 50 consecutive patients undergoing lumbar spine surgery… Continue reading Cerebral Oxygenation Under General Anesthesia Can Be Safely Preserved in Patients in Prone Position: A Prospective Observational Study.
Anesthetic Challenges in the Management of Distal Posterior Cerebral Artery Aneurysm for Surgical Clipping: A Report of 2 Cases.
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Using the Swiss ball versus peanut ball to assess the back extensors endurance among healthy collegiate physical therapy students at Taibah University
2016-06-06T19-38-22Z *Source:* International Journal of Therapies and Rehabilitation Research Tarek Mohamed El-gohary; Osama A. Khaled. Spinal extensors endurance is a vital and fundamental pillar for the general endurance. Good endurance helps in injury prevention, and improves efficiency in all physical activities across different ages. Endurance testing of back extensors has been extensively examined in literature but there are many criticisms to the suitability and the practicality of the commonly used tests. The purpose of this study was to compare the endurance ability of the tr... περισσότερα »
Distribution of IL28B Polymorphism in a Cohort of Italians and Immigrants with HCV Infection: Association with Viraemia, Stage of Fibrosis and Response to Treatment
Abstract Aims of the study are to investigate, in a cohort of patients affected by HCV chronic hepatitis with genotypes 1 and 4, the prevalence of interleukin 28B (IL28B) genotypes, the possible association between IL28B polymorphism and severity of liver damage, the role of IL28B CC as a predictor of outcome. 365 patients with HCV infection were observed between 2013 and 2014. Demographic, virological, biochemical, and genetic characteristics of each patient were investigated. Liver fibrosis was assessed by transient elastometry. Mean age of the patients (72.9 % males, 27.1 % femal... περισσότερα »
Indigenous Adolescents’ Suicidal Behaviors and Risk Factors: Evidence from the National Youth Risk Behavior Survey
Abstract The study sought to examine indigenous adolescents’ suicidal behaviors and risk factors in a nationally representative sample and explore potential causes of disparities. The study analyzed the 1991–2013 Youth Risk Behavior Survey National Combined Datasets. Suicidal behavior outcomes included suicide consideration, planning, and attempts during the past 12 months. Logit regressions were used to estimate the effects of potential suicide risk factors on these suicidal behaviors. The results showed that a high percentage of indigenous adolescents exhibited suicidal behaviors ... περισσότερα »
Ethnic Disparities in Blood Pressure: A Population-based Study
Abstract Taiwan’s indigenous population exhibits a higher mortality of cardiovascular disease, but current research has not reported any associations among ethnicities on the blood pressure (BP). We randomly selected representative samples in this population-based study. We measured height, weight, hip and waist circumferences, and blood pressure in a screening survey. Systolic BP and diastolic BP were significantly higher in the indigenous population. Among women, prevalence rates of DBP > 90 mmHg among indigenes (32.9 %) were significantly high than those in Han Chinese (17.4 %).... περισσότερα »
Supernumerary renal vessels: analysis of frequency and configuration in 996 computed tomography studies
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Background: Number, course and division pattern of renal vessels is highly variable. Variant renal vasculature is of high interest in nephrectomy for the renal transplantations, both in deceased and living donors. The purpose of the study was to analyse the frequency of supernumerary renal vessels in a large cohort of patients undergoing the multiphase abdominopelvic […]
Cone beam computed tomography investigation of the antral artery anastomosis in a population of Central Italy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Background: The arterial vascular supply of maxillary sinus has to be considered in all the surgical procedures where it is involved. In particular, the intraosseous anastomosis between the posterior superior alveolar artery and the infraorbital artery branches in the bony canal can be tricky to a not well aware clinician. The aim of this study […]
Morphological characteristics of the sinus node on postmortem tissue
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
The sinus node is an intensively researched structure in terms of anatomical, histological, electrophysiological, molecular and genetic approach. For postmortem diagnosis it is still difficult to investigate due to a still reduced accessibility. In this study we tried and succeed to apply molecular biology techniques on postmortem tissues in order to widen the range of […]
A cephalic vein drained into one of the double axillary veins through the pectoralis major muscle
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Although the cephalic vein follows a fairly consistent course, numerous variants have been reported. We found a rare anatomical presentation of the cephalic vein in a 43-year-old Korean male cadaver. The cephalic vein had anastomosed with the basilic vein and brachial vein at the level of the elbow, perforated the pectoralis major muscle between the […]
Porcine liver vascular bed in Biodur E20 corrosion casts
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Background: Pigs are frequently used as animal models in experimental medicine. To identify processes of vascular development or regression, vascular elements must be recognised and quantified in a three-dimensional (3D) arrangement. Vascular corrosion casts enable the creation of 3D replicas of vascular trees. The aim of our study was to identify suitable casting media and […]
Lymphatic vessels around the uterus: D2-40 (podoplandin) immunohistochemistry using elderly cadavers
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Using D2-40 immunohistochemistry, we examined the morphology of lymphatic vessels (LVs) in, along and around the uterus of 10 donated female cadavers (mean age, 85 years). All these women had 1 or 2 children with vaginal delivery, but the other obstetrics information was unknown. When compared with the bladder, vagina and the subperitoneal tissue, the […]
Fine structure of the dorsal lingual epithelium in Tarentola annularis and Crocodylus niloticus
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
The present study examined the morphological features, histological and histochemical aspect of the tongue of two reptilian species, Tarentola annularis (family: Gekkonidae) and Crocodylus niloticus (family: Crocodylidea), with different habitats, feeding patterns and behaviours, by light and scanning electron microscope. It was observed, that the bifurcation of the tongue was more visible in Tarentola annularis. […]
