Head &Neck, EarlyView.
https://ift.tt/2GgW0nV
Δευτέρα 14 Μαΐου 2018
Neutrophil‐to‐lymphocyte ratio as a prognostic indicator in head and neck cancer: A systematic review and meta‐analysis
Preoperative predictors of occult nodal disease in cT1N0 oral cavity squamous cell carcinoma: Review of 2623 cases
Head &Neck, EarlyView.
https://ift.tt/2rHAlRk
Volvulus with bowel necrosis after laparoscopic appendectomy. Migration of Clip?
Abstract
About 2.8% of patients develop small bowel obstruction, mostly following an open approach appendectomy. Case Report: we present an 18-year-old girl with acute abdomen 10 days following laparoscopic appendectomy. An emergency laparotomy was performed which revealed bowel necrosis and an impacted slipped clip on the mesenterial side of the bowel with signs of bowel strangulation and necrosis. Bowel resection was carried out with primary enteroenteric anastomosis. We suspect the sharp ends of the open clip allowed it to become lodged in the bowel segment resulting in bowel obstruction and subsequent necrosis. It is possible that the clip migrated or was a failed deployment. To our knowledge, this is the first report of mechanical bowel obstruction after laparoscopic appendectomy caused by aberrant surgical clip.https://ift.tt/2KqUL8h
Otolaryngology and the Global Burden of Disease
The Global Burden of Disease (GBD) project provides longitudinal analysis of the global burden of otolaryngologic diseases by measuring the all-cause mortality, years of life lost, the years of life lived with disability, and disability-adjusted life years. Hearing loss burden is assessed overall and as sequelae of other diseases, such as otitis media or meningitis. Using these measures, we can appreciate the high prevalence and disability related to hearing loss globally. Other otolaryngologic diseases that contribute to the GBD include otitis media, cleft lip and palate, head and neck cancer, facial trauma, and oral disorders.
https://ift.tt/2wGDDcD
The Small World of Global Otolaryngology
The world is indeed becoming smaller, and the medical field has been transformed by this rapid globalization. As global communication and travel have increased, the Otolaryngology-Head and Neck Surgery community has also become increasingly connected and interwoven across the world, from highly sophisticated tertiary care centers to rural communities in developing countries. As medical professionals, it has always been a part of our fiber to impart information and skills that improve the lives of patients; now, more than ever, it is incumbent upon physicians to share expertise on a global scale.
https://ift.tt/2KkEBx5
Regional Overview of Specific Populations, Workforce Considerations, Training, and Diseases in Latin America
Latin America has significant disparities that make the region vulnerable in the delivery of health care. There is a need to plan comprehensive health care strategies that result in a more robust trained health care workforce, while improving the quality and efficiencies of tertiary public hospitals. This article introduces a survey conducted among otorhinolaryngology leaders in the region that identified the need to strengthen postgraduate programs. Although all countries in Latin America have at least one residency program, more otorhinolaryngology-trained specialists are necessary to address the workforce shortages that are present in about 50% of Latin American countries.
https://ift.tt/2Kpz9c6
Low or Undetectable Basal Thyroglobulin Levels Obviate the Need for Neck Ultrasound in Differentiated Thyroid Cancer Patients After Total Thyroidectomy and 131I Ablation
Thyroid, Ahead of Print.
https://ift.tt/2rJjlcO
An anti-NMDA receptor encephalitis mimicking an HIV encephalitis
Source:Clinical Immunology
Author(s): Fatiha Haneche, Sophie Demeret, Dimitri Psimaras, Christine Katlama, Valérie Pourcher
The incidence of HIV associated neurocognitive disorders (HAND) were reduced with the use of antiretroviral therapy. In case of neuropsychiatric symptoms, after elimination of all infections, auto-immune encephalitis could be evocated as a differential diagnosis. We describe a case of anti-N-Methyl-d-Aspartate receptor encephalitis in an HIV-1 infected woman.
https://ift.tt/2IiD2iI
Networked Individuals, Gendered Violence: A Literature Review of Cyberviolence
Violence and Gender, Ahead of Print.
https://ift.tt/2L0RYnl
Oesophageal causes of dysphagia localised only to the pharynx: Implications for the suspected head and neck cancer pathway
Clinical Otolaryngology, EarlyView.
https://ift.tt/2ILPbzU
Total glossolaryngectomy cohort study (N = 25): Survival, function and quality of life
Clinical Otolaryngology, EarlyView.
https://ift.tt/2jX7d4b
Identifying and siding the stylohyoid bone for North American artiodactyls
International Journal of Osteoarchaeology, EarlyView.
https://ift.tt/2GfyZSc
First evidence of elongated styloid process in two female archaeological individuals from Córdoba hills, Argentina (late Holocene)
International Journal of Osteoarchaeology, EarlyView.
https://ift.tt/2L2bSyo
VideoEndocrinology™ High-Impact Videos
VideoEndocrinology™
The Official Journal of: American Thyroid Association
FREE ACCESS through May 28, 2018.
Watch now:
Postoperative Continuous Pressure Monitoring in Thyroid Surgery: Pathophysiology of Post-Thyroidectomy Hemorrhage
Ulrich Wirth, Thomas von Ahnen, Stefan Schopf, Hans Martin Schardey
Transaxillary Robotic Parathyroidectomy: Huge Parathyroid Adenoma
Patrick Aidan, Maroun Bechara
Thyroid Fine-Needle Aspiration and Smearing Techniques
Mitsuyoshi Hirokawa, Ayana Suzuki, Akira Miyauchi
The post VideoEndocrinology™ High-Impact Videos appeared first on American Thyroid Association.
https://ift.tt/2wF0C7L
Long-term stability of mandibular advancement with bilateral sagittal split osteotomy
Aim of this study was 1) to evaluate long-term dental/skeletal stability in patients with mandibular retrognathia corrected by BSSO, and 2) to examine factors associated with relapse.
https://ift.tt/2GfoFtG
Subjective and Objective Appearance of Head and Neck Cancer Patients Following Microsurgical Reconstruction and Associated Quality of Life─A Cross-Sectional Study
Depending on the site and size of head and neck cancer, the disease affects patients' appearance and subsequently their quality of life. The aim of this study was to correlate subjective and objective evaluation of facial appearance and associated quality of life following ablative tumor surgery and microsurgical reconstruction.
https://ift.tt/2KYeCwy
Relapse related to pushing and rebounding action in maxillary anterior downgraft with mandibular setback surgery
Maxillary downgraft (MD) and mandibular setback (MS) are problematic procedures in terms of postoperative stability. While the amount of intraoperative clockwise rotation (CWR) of the proximal segment (PS) after MS combined with MD has a positive correlation with the amount of MD, mandibular relapse after MS with MD in relation to intraoperative CWR of the PS has not been reported. Moreover, the effect of mandibular relapse on maxillary stability after MS with MD remains unclear. The purpose of this study is to evaluate mandibular and maxillary stability after MS with MD in relation to intraoperative CWR of the PS and amount of MD.
https://ift.tt/2Ggcf4L
Adjustable selective maxillary expansion combined with one-stage maxillomandibular surgery: a prospective study of osseous widening in fifty-five consecutive patients
Maxillary transverse deficiency (MTD) is a very common in orthognathic surgery. However, correction of MTD in adults is challenging and can prove to be a surgical nightmare.
https://ift.tt/2L1UPwr
Treatment of pathologic fractures of the mandible in stage III medication-related osteonecrosis of the jaw—an observational study
The treatment of pathologic fractures in stage III medication-related osteonecrosis of the jaw (MRONJ) remains challenging. The treatment in the literature is controversial, varying from extensive and aggressive surgery with resections and musculocutaneous free flap reconstruction to conservative treatment with only mouth rinses and/or antimicrobial treatment. The purpose of this study was to analyse the results of the treatment protocol in the Leiden University Medical Center in the Netherlands.
https://ift.tt/2KVPIhb
Soluble urokinase‐type plasminogen activator receptor is associated with signs of periodontitis in adolescents
European Journal of Oral Sciences, EarlyView.
https://ift.tt/2IDLSuN
DNA replication licensing factor MCM2, geminin, and Ki67 define proliferative state and are linked with survival in oral squamous cell carcinoma
European Journal of Oral Sciences, Volume 126, Issue 3, Page 186-196, June 2018.
https://ift.tt/2KoTyOu
Author Guidelines
European Journal of Oral Sciences, Volume 126, Issue 3, Page 250-250, June 2018.
https://ift.tt/2k09XOd
Issue Information
European Journal of Oral Sciences, Volume 126, Issue 3, Page i-iii, June 2018.
https://ift.tt/2Kq9eRY
The role of sentinel lymph node biopsy as a staging procedure in patients with melanoma – A critical appraisal
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2rIlpCs
Contact dermatitis to Dermabond Advance®
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2wM3OhQ
A ticking time bomb: A case of Lyme disease
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2rH3Qme
Pancreatic panniculitis: A case series from a tertiary university hospital in Spain
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2wFFTRo
A rare case of chronic expanding haematoma in the occipital region mimicking a malignant soft tissue tumour
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2IgqE6V
Chemotherapy‐induced alopecia: A novel observation
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2wIr3JS
Successful treatment of a skin tears with a single‐use negative pressure wound therapy device
Dermatologic Therapy, EarlyView.
https://ift.tt/2wHRIqh
Noninvasive size reduction of lipoma with an insulated monopolar radiofrequency microneedle device
Dermatologic Therapy, EarlyView.
https://ift.tt/2rIkbqQ
Occupational asthma caused by high- and low-molecular weight agents in an auto body worker
Source:Annals of Allergy, Asthma & Immunology
Author(s): Isabel Coman, Pilar Barranco, Santiago Quirce
https://ift.tt/2IIOJ5O
Integrated behavioral health care for management of stress in allergic diseases
Publication date: Available online 8 May 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Alyssa Oland, Genery D. Booster, Bruce G. Bender
ObjectiveThe present article will review current findings regarding the management of stress in allergic disease.Data SourcesThe present review article uses articles and books published between 1995 and 2017. Approximately 85% of sources used were published in the last 10 years and 60% were published in the last 5 years. The majority of sources are peer-reviewed articles.Study SelectionsArticles that focused on allergic diseases such as allergic rhinitis, food allergies, urticaria, and allergic asthma were included in the present review. Articles in which it was not clear that the underlying disorder was allergic in nature (for example, non-specified asthma) were not included in the present review. Preference was given to articles published within the past five years.ResultsPatients with allergic diseases, particularly those with chronic and/or co-occurring allergic diseases, often experience stress and, in turn, this experience of stress can exacerbate disease presentation. High rates of treatment non-adherence in patients with allergic disease can also increase disease burden and stress. Research to date supports the benefit of behavioral health interventions for patients with allergic disease. Interventions with multidisciplinary teams, that include behavioral health, as well as interventions at the school, workplace, and community level are recommended.ConclusionMedical providers working with patients with allergic disease need to address patient's experience of stress and non-adherence to treatment recommendations. This could be done through routine screening and referrals to behavioral health or, ideally, through incorporation of a behavioral health provider within a multidisciplinary patient team.
https://ift.tt/2wEXJUt
Epinephrine, auto-injectors and anaphylaxis: challenges of dose, depth and device
Publication date: Available online 7 May 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Julie Brown
Objectives1. To review epinephrine dosing, site and route of administration, focusing on special populations (patients weighing less that 15 kg, and obese patients). 2. To discuss storage and delivery of epinephrine in pre-hospital and hospital settings.Data SourcesReview of published literature.Study SelectionRelevancy.ResultsThe recommended 0.01 mg/kg (max 0.3-0.5 mg) epinephrine dose in anaphylaxis is based on limited pharmacokinetic data in healthy volunteers. There are no pharmacokinetic or pharmacodynamics studies involving patients in anaphylaxis. When epinephrine auto-injectors (EAIs) are used in infants, the dose increasingly exceeds the recommended dose as weight decreases, although the clinical significance is unclear. Limited data indicate that the intramuscular route and lateral thigh site are superior. Ultrasound studies suggest that 0.15 EAI needles may be too long for many patients under 15 kg and 0.3 mg EAI needles may be too short for obese patients over 30 kg. A newly available 0.1 mg EAI has a lower dose and shorter needle better suited to patients 7.5-15 kg. In some medical settings, vials and syringes may provide a safe, efficient alternative with substantial cost savings over EAIs.ConclusionEAIs should be available in the community with doses and needle depths that meet the needs of all patients. More research on epinephrine pharmacodynamics are needed in children and adults in anaphylaxis, in order to better delineate what optimal doses should be. Optimizing epinephrine dose and delivery has the potential to improve anaphylaxis outcomes and prevent adverse events.
https://ift.tt/2IIOHec
Angioedema: systemic activation process during prodromes
Source:Annals of Allergy, Asthma & Immunology
Author(s): Samuel Luyasu, Delphine Charignon, Denise Ponard, Christian Drouet, Arije Ghannam
https://ift.tt/2KoIPUq
The impact of patient autonomy on older adults with asthma
Publication date: Available online 3 May 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Keerthi R. Karamched, Wei Hao, Peter X. Song, Laurie Carpenter, Joel Steinberg, Alan P. Baptist
BackgroundUnderstanding patient preferences and desire for involvement in making medical decisions is important when managing chronic conditions. Previous studies have utilized the Autonomy Preference Index (API) in younger asthmatic patients to evaluate these preferences.ObjectiveTo identify factors associated with autonomy, and to determine if autonomy is related to asthma outcomes among older adults.Methods189 older adults (>55 yr) with persistent asthma were included. Preferences for autonomy were assessed using the API, with a higher score indicating higher desire for autonomy. Scores were separated into two domains of 'information seeking' and 'decision making' preferences. The separated scores were correlated with asthma outcomes and demographic variables. To control for confounding factors, a linear regression analysis was performed.ResultsHigher 'decision making' preference scores correlated with female gender (p=0.007), higher education level (p=0.01), and lower depression scores (p=0.04). Regarding outcomes, 'decision making' scores positively correlated with asthma quality of life questionnaire (AQLQ) scores (p=0.01). On linear regression analysis, the AQLQ score remained significantly associated with 'decision making' preference scores (p=0.03). There was no association with asthma control test scores, spirometry values, and healthcare utilization. 'Information seeking' preference scores correlated with education level (p=0.03), but there was no correlation with asthma outcomes.ConclusionOlder asthmatic adults with a greater desire for involvement in decision making have a higher asthma related quality of life. Future studies with the intention to increase patient autonomy may help establish a causal relationship.
https://ift.tt/2IIPkV6
Development of a tool predicting severity of allergic reaction during peanut challenge
Publication date: Available online 27 April 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): R. Sharon Chinthrajah, Natasha Purington, Sandra Andorf, Jaime S. Rosa, Kaori Mukai, Robert Hamilton, Bridget Marie Smith, Ruchi Gupta, Stephen J. Galli, Manisha Desai, Kari C. Nadeau
BackgroundReliable prognostic markers for predicting severity of allergic reactions during oral food challenges (OFC) have not been established.ObjectiveWe sought to develop a predictive algorithm of a food challenge severity score (CSS) to identify those at higher risk for severe reactions to a standardized peanut OFC.MethodsMedical history and allergy tests were obtained for 120 peanut-allergic participants who underwent double-blind, placebo-controlled food challenges (DBPCFCs). Reactions were assigned a CSS between 1 to 6 based on cumulative tolerated dose and a "severity clinical indicator." Demographic characteristics, clinical features, peanut component IgE values, and a basophil activation marker were considered in a multi-step analysis to derive a flexible decision rule to understand risk during peanut of OFC.Results18.3% participants had a severe reaction (CSS >4). The decision rule identified the following three variables (in order of importance) as predictors of reaction severity: ratio of %CD63hi stimulation with peanut to %CD63hi anti-IgE (CD63 ratio), history of exercise-induced asthma, and forced expiratory volume in 1 sec/forced vital capacity (FEV1/FVC) ratio. The CD63 ratio alone was a strong predictor of CSS (p<0.001).ConclusionThe CSS is a novel tool that combines dose thresholds and allergic reactions to understand risks associated with peanut OFCs. Lab-values (CD63 ratio), along with clinical variables (exercise-induced asthma and FEV1/FVC ratio) contribute to the predictive ability of the severity of reaction to peanut OFC. Further testing of this decision rule is needed in a larger external data source before it can be considered outside of research settings.
https://ift.tt/2wLKeme
Suspected severe acute food protein-induced enterocolitis syndrome caused by cow's milk through breast milk
Source:Annals of Allergy, Asthma & Immunology
Author(s): Ines Vergara Perez, Leticia Vila Sexto
https://ift.tt/2jWxM9V
Dr. elliot f. ellis: initiating personalized asthma management in children
Publication date: Available online 11 May 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Stanley J. Szefler
Elliot F. Ellis is indeed a giant in the field of allergy and immunology. From his leadership role in developing a pediatric allergy and immunology fellowship at National Jewish Health and his seminal work in theophylline pharmacokinetics, he trained many excellent clinicians and researchers. He assumed the role of Chair of Pediatrics at the Children's Hospital of Buffalo in 1974 and transformed that training program in pediatrics to a top-rated program in the country along with his own training program in allergy and immunology. He co-edited the first edition of Allergy Principles and Practice with Elliott Middleton, Jr., MD and Charles E. Reed, MD. His clinical research provided the building blocks for personalized medicine in asthma, especially as it pertains to children.
https://ift.tt/2wLKce6
Aldolase: a new crustacea allergen
Source:Annals of Allergy, Asthma & Immunology
Author(s): P.M. Gamboa, B. Bartolomé, E. García Lirio, J. Cuesta-Herranz, C. Pastor-Vargas
https://ift.tt/2IIOBmQ
Information for Readers
Source:Annals of Allergy, Asthma & Immunology, Volume 120, Issue 5
https://ift.tt/2KoyfwM
Table of Contents
Source:Annals of Allergy, Asthma & Immunology, Volume 120, Issue 5
https://ift.tt/2jWxIab
Pain inhibits itch, but not in atopic dermatitis?
Source:Annals of Allergy, Asthma & Immunology, Volume 120, Issue 5
Author(s): Hjalte H. Andersen, Gil Yosipovitch, Lars Arendt-Nielsen
https://ift.tt/2KmyN6a
Information for Authors
Source:Annals of Allergy, Asthma & Immunology, Volume 120, Issue 5
https://ift.tt/2IIPbRy
Immunology, Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy. Edited by M.A. Hayat. San Diego, CA: Elsevier Science, Academic Press. Soft copy, 255 pages, $213.00. ISBN: 978-0-12-809819-6.
Source:Annals of Allergy, Asthma & Immunology, Volume 120, Issue 5
Author(s): Jonathan A. Bernstein
https://ift.tt/2wEfAuX
Editorial Board
Source:Annals of Allergy, Asthma & Immunology, Volume 120, Issue 5
https://ift.tt/2jUXM5n
From the pages of allergywatch June 2018
Publication date: Available online 26 April 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): David Michael Lang, Stanley M. Fineman, David A. Khan, Stephen A. Tilles
https://ift.tt/2wEfxzh
Looking into the seeds of time
Source:Annals of Allergy, Asthma & Immunology, Volume 120, Issue 5
Author(s): Matthew Greenhawt, Jonathan O'B. Hourihane
https://ift.tt/2jV5xIw
Food allergy to previously tolerated foods: course and patient characteristics
Publication date: Available online 21 April 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Liat Nachshon, Michael R. Goldberg, Arnon Elizur, Michael Y. Appel, Michael B. Levy, Yitzhak Katz
https://ift.tt/2wHRHCv
School exposure and asthma
Source:Annals of Allergy, Asthma & Immunology, Volume 120, Issue 5
Author(s): Brittany Esty, Wanda Phipatanakul
ObjectiveTo provide a comprehensive overview of common school exposures and the association between school exposures and pediatric asthma morbidity.Data SourcesA comprehensive literature review was performed using PubMed.Study SelectionsFull-length, peer-reviewed studies published in English were considered for review. In vivo, in vitro, and animal studies were excluded. Studies of school exposure to cockroach, mouse, dust mite, dog, cat, molds, pollution, and endotoxin associated with asthma and asthma morbidity were considered.ResultsThe current literature establishes an association between school exposure and pediatric asthma morbidity. There is a need for ongoing research to evaluate the effects of school-based environmental interventions on asthma morbidity.ConclusionIt is evident that the indoor school environment is a significant reservoir of allergens, molds, pollutants, and endotoxin and that there is an association between school exposure and pediatric asthma morbidity. School-based interventions have the potential for substantial individual, community, and public health benefit. It is important that researchers continue to study the health effects associated with school exposures and assess cost-effectiveness of multifaceted school-based interventions.
https://ift.tt/2wD6nmk
Authors' response
Source:Annals of Allergy, Asthma & Immunology, Volume 120, Issue 5
Author(s): Jonathan I. Silverberg, Kevin R. Patel, Vivek Singam
https://ift.tt/2Ijrpw5
Promoting new concepts of skincare via skinomics and systems biology—From traditional skincare and efficacy‐based skincare to precision skincare
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2IIJ5QX
Antioxidant properties evaluation of topical astaxanthin formulations as anti‐aging products
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2IiDgGh
Does the gastrointestinal microbiome contribute to the ‘obesity paradox’ in melanoma survival?
British Journal of Dermatology, EarlyView.
https://ift.tt/2jZ8sQy
The prevalence of honorary authorship in the dermatological literature
British Journal of Dermatology, EarlyView.
https://ift.tt/2KqxAdZ
Automated scoring of vitiligo using superpixel‐generated computerized digital image analysis of clinical photographs: a novel and consistent way to score vitiligo
British Journal of Dermatology, EarlyView.
https://ift.tt/2IE9hwc
Profound consequences of hidradenitis suppurativa: a review
British Journal of Dermatology, EarlyView.
https://ift.tt/2KqxqTV
Baseline neutrophil‐to‐lymphocyte ratio in patients with advanced melanoma treated with immune checkpoint inhibitors
British Journal of Dermatology, EarlyView.
https://ift.tt/2jYaG2K
Drug survival of secukinumab for moderate‐to‐severe plaque psoriasis: reply from authors
British Journal of Dermatology, EarlyView.
https://ift.tt/2Kqxinp
Asthma‐COPD Overlap Syndrome among subjects with newly diagnosed adult‐onset asthma
Allergy, EarlyView.
https://ift.tt/2L0zzqP
Early‐life secondhand smoke exposure and food hypersensitivity through adolescence
Allergy, EarlyView.
https://ift.tt/2GgkXzU
Issue Information ‐ Cover and Editorial Board
Allergy, Volume 73, Issue 5, Page 967-967, May 2018.
https://ift.tt/2Gh9rEi
A retrospective study of dermatitis herpetiformis from an immunobullous disease clinic in north India
International Journal of Dermatology, EarlyView.
https://ift.tt/2wLGMYO
Suppurative cribriform ulcers in one leg
International Journal of Dermatology, EarlyView.
https://ift.tt/2jZ70xA
Teaching & Learning Tips 8: Preparing to teach in ambulatory settings
International Journal of Dermatology, Volume 57, Issue 6, Page 715-718, June 2018.
https://ift.tt/2KpuzL7
Issue Information
International Journal of Dermatology, Volume 57, Issue 6, Page i-iii,625-626, June 2018.
https://ift.tt/2jUzmsH
Superficial acral fibromyxoma with bony change: Successful treatment with en bloc nail excision using a full‐thickness skin graft
International Journal of Dermatology, EarlyView.
https://ift.tt/2Kqvvib
Periumbilical purpura: dermatoscopic findings in disseminated strongyloidiasis
International Journal of Dermatology, EarlyView.
https://ift.tt/2jXdKMA
Eruptive pseudoangiomatosis in two children with acute lymphoblastic leukemia
International Journal of Dermatology, EarlyView.
https://ift.tt/2wLGC3E
Socioeconomic status and survival for patients with melanoma in the United States: an NCDB analysis
International Journal of Dermatology, EarlyView.
https://ift.tt/2IGavqB
Frontal fibrosing alopecia: is the melanocyte of the upper hair follicle the antigenic target?
International Journal of Dermatology, EarlyView.
https://ift.tt/2KpY67E
Ewing′s sarcoma metastatic to skin: a case report and review of the literature
International Journal of Dermatology, EarlyView.
https://ift.tt/2jUblSK
Issue Information
Pediatric Dermatology, Volume 35, Issue 3, Page 291-295, May/June 2018.
https://ift.tt/2Ges1gc
A child with peculiar pigmentation after a bout of fever
Pediatric Dermatology, Volume 35, Issue 3, Page 408-409, May/June 2018.
https://ift.tt/2KXL6XE
Firm, protuberant plaque on a 7‐year‐old's arm
Pediatric Dermatology, Volume 35, Issue 3, Page 403-405, May/June 2018.
https://ift.tt/2Gg5qA5
Extensive hypopigmented cribriform lesions with fine scaling in a child
Pediatric Dermatology, Volume 35, Issue 3, Page 410-412, May/June 2018.
https://ift.tt/2rGIiGl
Twelve‐year‐old boy with multiple waffle‐like purpuric patches
Pediatric Dermatology, Volume 35, Issue 3, Page 406-407, May/June 2018.
https://ift.tt/2Gf7doU
Multiple anogenital hemorrhagic blisters in a 2‐year‐old girl
Pediatric Dermatology, Volume 35, Issue 3, Page 413-414, May/June 2018.
https://ift.tt/2Kntp2V
Patient Perspectives: Risks of indoor tanning
Pediatric Dermatology, Volume 35, Issue 3, Page 401-402, May/June 2018.
https://ift.tt/2k0FTCt
Stapes surgery preserving the superstructure of stapes (Takagi’s stapedotomy) in otosclerosis: A retrospective study of 24 consecutive cases
The aim of this study was to evaluate the hearing outcomes and complications of stapedotomy in which the stapes superstructure was preserved (Takagi's stapedotomy). In this surgical approach, the lenticular process of the incus rather is removed, than the superstructure of the stapes.
https://ift.tt/2rItLJK
Retiform hemangioendothelioma presenting as a pedunculated nodule on the site of an inguinal pyoderma chronica
The Journal of Dermatology, EarlyView.
https://ift.tt/2jXz6sQ
Comparison of ultrasonographic findings of schwannomas and angioleiomyomas
The Journal of Dermatology, EarlyView.
https://ift.tt/2wBmwsy
Long‐term safety and efficacy of continuous acitretin monotherapy for three children with different severe hyperkeratotic disorders in China
The Journal of Dermatology, EarlyView.
https://ift.tt/2jU2EYm
Dystrophic calcinosis cutis of the auricles after injury in Down's syndrome
The Journal of Dermatology, EarlyView.
https://ift.tt/2wIzLrw
Tuberculous granuloma developed 9 years after bacillus Calmette–Guérin vaccination in a patient with immunodeficiency
The Journal of Dermatology, EarlyView.
https://ift.tt/2IHFmmL
Customized reconstruction with modified keystone flaps
The Journal of Dermatology, EarlyView.
https://ift.tt/2wBmrFg
Successful treatment of plaque‐type psoriasis by granulocyte and monocyte adsorption apheresis in a patient with psoriatic arthritis
The Journal of Dermatology, EarlyView.
https://ift.tt/2jU2BMa
Novel mutations in Chinese Han patients with tuberous sclerosis complex: Case series and review of the published work
The Journal of Dermatology, EarlyView.
https://ift.tt/2wIzFQG
Asian consensus on assessment and management of mild to moderate plaque psoriasis with topical therapy
The Journal of Dermatology, EarlyView.
https://ift.tt/2k01zyd
Hailey–Hailey disease patient with a novel missense mutation in ATP2C1 successfully treated with minocycline hydrochloride
The Journal of Dermatology, EarlyView.
https://ift.tt/2wG9s5o
Issue Information
Journal of Oral Pathology &Medicine, Volume 47, Issue 5, Page i-i, May 2018.
https://ift.tt/2jY8GaK
Assessment of two screening tools to identify psoriatic arthritis in patients with psoriasis
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2rH7Rr2
The impact of psoriasis on professional life: PsoPRO, a French national survey
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2GezWKR
Detection of titanium nanoparticles in the hair shafts of a patient with frontal fibrosing alopecia
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2L0xNpF
Acne and nutrition: hypotheses, myths and facts
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2Gg3is5
Dermoscopic features of melanocytic skin lesions in Greek children and adolescents and their association with environmental factors and skin types
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2L0qUV6
A case of neutrophilic dermatoses including pyoderma gangrenosum as a continuous disease spectrum to SAPHO syndrome
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2GdLbTv
Searching for a mathematical model for blood perfusion of random pattern skin flaps: a clinical pilot study using in vivo laser speckle contrast imaging
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2GgfSY9
Impact of the mechanical hyperkeratotic lesions and its association with quality of life: An observational case–control study
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2rJiQjF
Response to ‘Psoriasis patients’ preference for an aerosol foam topical formulation’ by Vender R et al.
Journal of the European Academy of Dermatology and Venereology, EarlyView.
https://ift.tt/2Gf460c
Localized genital bullous pemphigoid
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2KZkLZn
Unilateral periorbital swelling: a diagnostic dilemma
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2GdLei9
Oral Fumaderm® to treat cutaneous sarcoidosis
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2L1VMEH
Rapid growth rate is associated with poor prognosis in cutaneous squamous cell carcinoma
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2rJibyH
Cutaneous manifestations of JAK2+ myeloproliferative neoplasms
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2GeoEpy
Sustained response of graft‐versus‐host disease‐associated angiomatosis treated with propranolol
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2rH1Sm7
A polymorphous rash of an uncommon blistering disease
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2GdL6iF
Association between serum interleukin‐17A and clinical response to tofacitinib and etanercept in moderate to severe psoriasis
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2L0n3aH
A solitary and tender acral papule in a young patient
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2GdKZUh
CD8+ T cell‐mediated interface dermatitis during combination chemotherapy with mogamulizumab in a patient with adult T‐cell leukaemia/lymphoma
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2KZkGF3
Tattoo‐related squamous proliferations: a spectrum of reactive hyperplasia
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2GeoAWQ
A rare missense mutation in GJB3 (Cx31G45E) is associated with a unique cellular phenotype resulting in necrotic cell death
Experimental Dermatology, EarlyView.
https://ift.tt/2IFQqRe
Reduction in ultraviolet B light–induced erythema by oxymetazoline and brimonidine is mediated by different α‐adrenoceptors
Experimental Dermatology, EarlyView.
https://ift.tt/2InsuP8
Issue Information
Experimental Dermatology, Volume 27, Issue S1, Page 1-4, May 2018.
https://ift.tt/2IFQfp2
Author Index
Experimental Dermatology, Volume 27, Issue S1, Page 33-35, May 2018.
https://ift.tt/2InsoXM
Abstracts
Experimental Dermatology, Volume 27, Issue S1, Page 5-32, May 2018.
https://ift.tt/2IG4mKV
Lipidomics for translational skin research: A primer for the uninitiated
Experimental Dermatology, EarlyView.
https://ift.tt/2ImYovj
Narrow band imaging for risk stratification of glottic cancer within leukoplakia
Head &Neck, EarlyView.
https://ift.tt/2GiHw7e
Age‐adjusted comorbidity and survival in locally advanced laryngeal cancer
Head &Neck, EarlyView.
https://ift.tt/2rFM4Qy
Free jejunal flap transfer with multiple vascular pedicles for safe and reliable pharyngoesophageal reconstruction
Head &Neck, EarlyView.
https://ift.tt/2GgdS27
Survival without adjuvant chemotherapy for selected patients with stage II and III nasopharyngeal carcinoma after concurrent chemoradiotherapy alone
Head &Neck, EarlyView.
https://ift.tt/2KXZrn4
Topical superoxide dismutase in posttreatment fibrosis in patients with head and neck cancer
Head &Neck, EarlyView.
https://ift.tt/2GiHlsA
Successful treatment of severe facial lymphedema by lymphovenous anastomosis
Head &Neck, EarlyView.
https://ift.tt/2rGONcj
Esthesioneuroblastoma with distant metastases: Systematic review & meta‐analysis
Head &Neck, EarlyView.
https://ift.tt/2Gg1aAB
Age‐related differences in health‐related quality of life among thyroid cancer survivors compared with a normative sample: Results from the PROFILES Registry
Head &Neck, EarlyView.
https://ift.tt/2rFM4jw
Ewing sarcoma of the head and neck: The Mayo Clinic experience
Head &Neck, EarlyView.
https://ift.tt/2GdzjB6
Oral cancer involving masticator space (T4b): Review of literature and future directions
Head &Neck, EarlyView.
https://ift.tt/2GeIXUa
Early outcomes in transoral vestibular thyroidectomy: Robotic versus endoscopic techniques
Head &Neck, EarlyView.
https://ift.tt/2rGZKL9
Primary intestinal‐type adenocarcinoma of the oral tongue: Case report and review of histologic origin and oncologic management
Head &Neck, EarlyView.
https://ift.tt/2Gg19g1
Value of CT added to ultrasonography for the diagnosis of lymph node metastasis in patients with thyroid cancer
Head &Neck, EarlyView.
https://ift.tt/2rGZFXR
Effect of cell‐phone radiofrequency on angiogenesis and cell invasion in human head and neck cancer cells
Head &Neck, EarlyView.
https://ift.tt/2GeIMIu
Adjuvant therapy in major salivary gland cancers: Analysis of 8580 patients in the National Cancer Database
Head &Neck, EarlyView.
https://ift.tt/2rGXJOO
Marsupialization of mandibular cystic ameloblastoma: Retrospective study of 7 years
Head &Neck, EarlyView.
https://ift.tt/2GeIDVs
Prognostic stratification of patients with nasopharyngeal carcinoma based on tumor immune microenvironment
Head &Neck, EarlyView.
https://ift.tt/2Km6lRR
Nasal fibroscopy as a routine screening procedure of sinonasal adenocarcinoma of woodworkers: French longitudinal case study
Head &Neck, EarlyView.
https://ift.tt/2IfFs5M
Perioperative risk factors that predict complications of radial forearm free flaps in oral and maxillofacial reconstruction
The aim of the study was to find out what perioperative risk factors predicted complications in patients having reconstructions with radial forearm free flaps (RFFF). We organised a retrospective study of 169 patients (mean (range) age 54 (22–86) years, 100 of whom were female) who had oral and maxillofacial tumours resected, and reconstructed with RFFF, from January 2011–December 2016. We recorded predictive variables, subdivided into: personal and clinical (sex, age, weight, coexisting conditions, history of smoking, radiotherapy, and primary lesions); haemodynamic (perioperative concentrations of haemoglobin and albumin, blood loss, blood transfusion, urinary output (ml), and rate (ml/kg/hour), and infusion rates for crystalloids and colloids (ml/kg/hour, and volumes given intraoperatively and postoperatively for 24hours); and anaesthetic and surgical (American Society of Anesthesiologists(ASA) grade, visual analogue pain score (VAS), and duration of tourniquet and operation).
https://ift.tt/2IFvfPm
Application of a resin handle for preparation of lamina for osteo-odontokeratoprosthesis
An osteo-odontokeratoprosthesis is an autograft that replaces the cornea with a polymethylmethacrylate (PMMA) optical cylinder mounted on a tooth-bone-periodontal complex. The procedure, which was first described in 1963 by Strampelli1 and modified by Falcinelli et al about 10years later,2 is the treatment of choice for conditions such as Stevens–Johnson syndrome, ocular cicatricial pemphigoid, multiple failed grafts, or chemical burns.
https://ift.tt/2KovjQO
Refinement of the approach in virtual surgical planning of osseous genioplasty
We present an unusual case of a CAD/CAM-assisted genioplasty for a three-dimensional deformity, which we think illustrates a technique that is better than current ones.
https://ift.tt/2jU4ngy
Re: Effectiveness of irrigation with chlorhexidine after removal of mandibular third molars: a randomised controlled trial
We read with interest the recent study by Cho et al1 because it is our policy to irrigate extraction sockets with saline to avoid the risk of chlorhexidine-related hypersensitivity. We think that this practice is mirrored throughout UK dental institutions.
https://ift.tt/2KpQphM
Cerebral amyloid angiopathy mimicking central nervous system metastases: a case report
This case describes an unusual presentation of an intracranial hemorrhage first thought to be metastatic disease on computed tomography and magnetic resonance imaging. The healthcare team completed an exhausti...
https://ift.tt/2Gh2d38
Orbital T-cell lymphoma in youngest recorded patient – early diagnosis, management, and successful outcome: a case report and review of the literature
Primary orbital peripheral T-cell lymphoma, not otherwise specified is an exceedingly rare disorder with a very poor outcome, and to the best of our knowledge only a few cases have been reported in the English...
https://ift.tt/2rJftt1
A blind area of origins of epistaxis: technical or cognitive?
Abstract
Purpose
To investigate common origins and features of anterior epistaxis.
Methods
Patients (168) with anterior nose bleed were studied from May to October 2013. Endoscopic examination with angled endoscope and then subsequent management (radiofrequency, selective packing,) was performed.
Results
Under thorough nasal endoscopy, anterior nasal bleeding origin was ranked in turn as follows: the anterior nasal septum (NS 83.3%), the small area of anterior lateral wall of nasal cavity corresponding to the nasal back (NB 7.1%), the anterior end of the inferior turbinate (IT 5.4%), and the nasal part of the nasal cavity roof (NR 4.2%). Arterial lesion and hypertension led to large instant quantity of bleeding; hypertension and negligible bleeding origin prolonged bleeding duration. Bleeding was successfully controlled with nasal endoscopy and radiofrequency or selective packing.
Conclusions
The arterial bleeding small area of anterior lateral wall of nasal cavity corresponding to the nasal back and the nasal part of the nasal cavity roof accounted for more than 10% of anterior epistaxis and a thorough endoscopic examination should include these area with angled endoscope. Then radiofrequency and selective packing will sharply reduce the bleeding duration.
https://ift.tt/2Kjw3qo
Septal branches of the anterior ethmoidal artery: anatomical considerations and clinical implications in the management of refractory epistaxis
Abstract
Purpose
Epistaxis is a commonly presenting complaint. In severe cases, nosebleeds may occur despite antero-posterior nasal packing and often in the absence of identifiable sources of bleeding. In such cases, epistaxis may occur from septal branches of the anterior ethmoidal artery (sbAEA). The purposes of this study are to highlight the clinical role of the sbAEA in different fields of endoscopic endonasal surgery and to evaluate the efficacy and safety of their selective endoscopic endonasal ligation in the management of refractory epistaxis.
Methods
A retrospective review was performed of all patients presenting with epistaxis who underwent endoscopic endonasal coagulation of sbAEA in three Italian tertiary-care referral centers between October 2010 and October 2017.
Results
A total of 30 patients met the inclusion criteria. Sixteen patients had never experienced nosebleeds before, while 14 patients recalled previous epistaxes. Seventeen patients were treated under local anesthetic, while 13 required general anesthesia. No intra- or post-operative complications were observed and none of the patients received nasal packing after the procedure. In all cases the coagulation was effective in controlling the bleeding, with only two relapses in the series (2/30, 6.7%).
Conclusions
The sbAEA are of great interest in endoscopic endonasal surgery, both as surgical landmarks and as feeding vessels for a variety of pedicled nasal flaps. What is more, they can be crucial for the management of refractory epistaxis. Their selective endoscopic coagulation represents an effective and safe procedure in cases of difficult-to-control epistaxis from the upper nasal fossa, with several advantages over nasal packing.
https://ift.tt/2KoQfXV
Synchronized roles of pannexin and connexin in nasal mucosal epithelia
Abstract
Background
Nasal mucosal epithelial cells express connexins, the prototypical gap junction proteins, and pannexins, a new family of channel proteins homologous to the invertebrate gap junction proteins. The physiological and pathophysiological roles of these transmembrane proteins in nasal mucosa are largely still unknown.
Purpose
Pannexins participate in ATP release into the extracellular space in various tissues, and ATP plays important roles in mucociliary clearance, especially by regulating ciliary beat activity. Therefore, we focused on the functional relationship between connexins, pannexin-1, ATP release, and mucociliary clearance in nasal epithelia.
Results and Conclusions
Connexins participate in the generation of intercellular calcium waves, in which calcium-mediated signaling responses spread to contiguous cells through the gap junction formed by connexins to transmit calcium signaling throughout the airway epithelium. Pannexins in the nasal mucosa may contribute to not only ciliary beat modulation via ATP release, but also regulation of mucus blanket components via H2O efflux. The synchronized roles of pannexin and connexin may provide a new insight into effective mucociliary clearance systems in nasal mucosa.
https://ift.tt/2KoOz0C
The predictive value of polysomnography combined with quality of life for treatment decision of children with habitual snoring related to adenotonsillar hypertrophy
Abstract
Purpose
Both surgical treatment and non-surgical treatment are suggested by clinicians for children with habitual snoring related to adenotonsillar hypertrophy; However, how should the decision be made remains unclear. The objective of this study was to investigate potential predictors for the treatment decision, i.e., surgical treatment vs wait and see in children with habitual snoring related to adenoidal and/or tonsillar hypertrophy.
Methods
Children with complaints of snoring and/or apnea associated with adenotonsillar hypertrophy who received polysomnography (PSG) monitoring at our Hospital were recruited. After at least 6 months, the subjects were followed up and grouped according to whether or not they had received adenoidectomy and/or tonsillectomy (AT) execution. The heights, weights, as well as the quality of life (assessed using the obstructive sleep apnea-18 (OSA-18) quality of life questionnaire) and baseline PSG of the subjects were recorded and compared. Two logistic regressions were performed to reveal the factors influencing decision-making on conducting AT.
Results
A total of 509 children were finally included (345 males and 164 females). Among these children, 287 eventually received AT. Significant differences in age, scores for item 1 and 5 of the OSA-18, apnea–hypopnea index, obstructive apnea index, obstructive apnea–hypopnea index (OAHI), and Lowest arterial oxygen saturation (P < 0.05) were observed between groups. By multivariate logistic regression, the factors that influenced the surgical decision were identified as follows: age < 7 years (P = 0.008: odds ratio [OR] = 1.667, 95% confidence interval [CI] 1.140–2.438), score for item 5 of OSA-18 > 4 points (P = 0.042: OR = 1.489, 95% CI 1.014–2.212) and OAHI > 1/h (P = 0.044: OR = 1.579, 95% CI 1.013–2.463).
Conclusion
School-age children aged < 7 years, with OAHI > 1/h and mouth breathing scored > 4 points were more likely to receive AT during the disease process and thus require increased attention.
https://ift.tt/2rHaFUV
Procedure-specific assessment tool for flexible pharyngo-laryngoscopy: gathering validity evidence and setting pass–fail standards
Abstract
Objective
The attainment of specific identifiable competencies is the primary measure of progress in the modern medical education system. The system, therefore, requires a method for accurately assessing competence to be feasible. Evidence of validity needs to be gathered before an assessment tool can be implemented in the training and assessment of physicians. This evidence of validity must according to the contemporary theory on validity be gathered from specific sources in a structured and rigorous manner. The flexible pharyngo-laryngoscopy (FPL) is central to the otorhinolaryngologist. We aim to evaluate the flexible pharyngo-laryngoscopy assessment tool (FLEXPAT) created in a previous study and to establish a pass–fail level for proficiency.
Methods
Eighteen physicians with different levels of experience (novices, intermediates, and experienced) were recruited to the study. Each performed an FPL on two patients. These procedures were video recorded, blinded, and assessed by two specialists. The score was expressed as the percentage of a possible max score. Cronbach's α was used to analyze internal consistency of the data, and a generalizability analysis was performed. The scores of the three different groups were explored, and a pass–fail level was determined using the contrasting groups' standard setting method.
Results
Internal consistency was strong with a Cronbach's α of 0.86. We found a generalizability coefficient of 0.72 sufficient for moderate stakes assessment. We found a significant difference between the novice and experienced groups (p < 0.001) and strong correlation between experience and score (Pearson's r = 0.75). The pass/fail level was established at 72% of the maximum score. Applying this pass–fail level in the test population resulted in half of the intermediary group receiving a failing score.
Discussion
We gathered validity evidence for the FLEXPAT according to the contemporary framework as described by Messick. Our results support a claim of validity and are comparable to other studies exploring clinical assessment tools. The high rate of physicians underperforming in the intermediary group demonstrates the need for continued educational intervention.
Conclusion
Based on our work, we recommend the use of the FLEXPAT in clinical assessment of FPL and the application of a pass–fail level of 72% for proficiency.
https://ift.tt/2rIEO6n
Influence of MP 29-02 on ciliary beat frequency in human epithelial cells in vitro
Abstract
Purpose
MP 29-02, which contains fluticasone propionate and azelastine hydrochloride, is used as a topical nasal application for the treatment of seasonal and perennial allergic rhinitis. Although a multitude of data is available on the clinical symptom reduction and treatment safety of MP 29-02, the effect of MP 29-02 on ciliary beat frequency (CBF) has not been evaluated thus far.
Methods
MP 29-02-containing solution was applied at concentrations of 2.5, 5, 10, and 20% to 14 healthy subjects, and nasal ciliated epithelial cells were then visualized using a phase-contrast microscope. CBF was measured after the application of MP 29-02. For a comparison, fluticasone propionate was used. CBF measurements were then performed for 15 min at 22 °C. Ringer's solution was applied as a negative control.
Results
MP 29-02 significantly reduced CBF at all the tested concentrations compared with that of the control group within the observation time. At a 2.5% concentration, MP 29-02 significantly reduced CBF from 6.81 Hz (SD ± 1.35 Hz) at baseline to 4.88 Hz (SD ± 1.52 Hz, p < 0.001) after 15 min. In contrast, for fluticasone propionate, a significant reduction was observed only with the 20% concentration after 5, 10, and 15 min.
Conclusions
MP 29-09 significantly reduced CB, with an almost linear relationship between the MP 29-09 concentration and reduction in CBF. For fluticasone propionate, a significant reduction of CBF was observed only at the highest analyzed concentration. The findings have implications for the long-term use of the MP 29-02. Yet, further clinical studies are needed to confirm these results in vivo, especially in patients with seasonal or perennial allergic rhinits.
https://ift.tt/2wEqtNg
Single nucleotide polymorphisms of IL-13 and CD14 genes in allergic rhinitis: a meta-analysis
Abstract
Purpose
The aim of this study was to conduct a meta-analysis for single nucleotide polymorphisms (SNPs) in interleukin-13 (IL-13) and cluster of differentiation 14 (CD14) genes and the risk for allergic rhinitis (AR).
Methods
We screened studies identified through seven databases including Pubmed, Medline, Web of Science, Embase, China Biology Medicine disc, Wanfang, and China Academic Journal Network Publishing Database. The odds ratios (ORs) and 95% confidence intervals (CIs) were determined to assess the association under allelic, dominant and recessive models.
Results
Twelve studies with a total of 8547 participants (3223 cases and 5324 controls) investigated IL-13 SNP rs20541, five studies combining 4580 participants (1411 cases and 3169 controls) examined IL-13 SNP rs1800925, and nine studies with 2301 participants (1174 cases and 1127 controls) assessed CD14 SNP rs2569190. We found that the A allele of IL-13 SNP rs20541 was associated with an increased risk of AR (OR 1.19, 95% CI 1.11–1.28, P < 0.001). Stratifying studies by ethnic group produced significant results in Asians (OR 1.21, 95% CI 1.11–1.32, P < 0.001), but not in Caucasians (OR 1.14, 95% CI 1.00–1.30, P = 0.051). No association of IL-13 SNP rs1800925 and CD14 SNP rs2569190 with AR risk was found in either Asians or Caucasians (P > 0.05).
Conclusion
Our findings suggest that IL-13 SNP rs20541 is significantly associated with AR risk in Asians but not in Caucasians. However, the accumulating evidence does not support an association of IL-13 SNP rs1800925 and CD14 SNP rs2569190 with AR risk.
https://ift.tt/2rFsXWu
Extramucosal pyriplasty without stenting for management of pyriform aperture stenosis
Abstract
Purpose
The current management options of congenital pyriform aperture stenosis (CNPAS) are either conservative measures awaiting further growth of the bony nasal framework or surgical intervention that focuses on bone removal from the margin of the pyriform aperture (PA) without exposure of the nasolacrimal duct (NLD) followed by stenting. Recently, CT measurements of the nasal cavity in CNPAS have shed light that the site of maximal bony obstruction corresponds to the bony buttress encasing the NLD rather than the margin of the PA as initially thought. Herein, we present an extramucosal pyriplasty technique that can be used without stenting to enlarge the PA and achieve immediate and sustained relief of nasal obstruction.
Methods
Retrospective chart review of 4 patients with radiologically confirmed CNPAS who had undergone extramucosal pyriplasty without stenting during the period from 2012 to 2016.
Results
Three patients were full term without any clinically detectable congenital anomaly. The fourth patient was preterm infant who needed ICU management. On computerized tomography scan, the PA width ranged from 5.8 to 7.1 mm with a mean of 6.4 mm while site of maximal stenosis ranged from 5.4 to 6.8 with a mean of 6 mm. Extramucosal pyriplasty relieved nasal obstruction and restored normal oral feeding in all patients. Postoperative follow-up endoscopy revealed an adequately patent airway with no scarring, granulation or restenosis.
Conclusions
Extramucosal pyriplasty with decompression of the NLD without stenting is a treatment modality for CNPAS that provides prompt sustainable relief of nasal obstruction and avoids the drawbacks of stenting and shortcomings of the current conservative methods.
https://ift.tt/2wENy2n
Antero- vs. retrograde nerve dissection in parotidectomy: a systematic review and meta-analysis
Abstract
Introduction
The retrograde approach (RP) to nerve identification is a method seldom used in parotid surgery. A systematic review comparing this method to the standard anterograde approach (AP) with respect to facial nerve palsy (FNP) does not currently exist.
Methods
In a meta-analysis according to the PRISMA statement, eight publications, including one randomized controlled trial, were selected. The primary aim was to compare the temporary and permanent FNP resulting from the two dissection methods. Facial nerve function was graded according to the House–Brackmann Scale. The secondary goal was a comparison of the cut–suture times (CST), the volume of healthy tissue (VHT) dissected, the rates of postoperative hematoma (PH), and postoperative infection (PI).
Results
Temporary FNP was noted in 18.2% in the RP group as well as in 34.4% in the AP group. Permanent FNP occurred in 0.9% RPs and 2.4% APs. According to the mixed-effect logistic regression model, there was no significant difference between the two groups in the pooled odds ratio (OR) for either temporary [OR 2.64, 95% confidence interval (CI) 0.97–7.21] or permanent FNP (OR 4.31, 95% CI 0.44–42.28). The CST was significantly shorter in the RP group (p = 0.005), with a significantly smaller VHT dissected (p < 0.0001). There were no differences regarding PH and PI.
Conclusion
The RP is a safe procedure with no significant difference in FNP rates when compared to the AP and, considering the shorter CST and the lesser VHT resected in the RP, it is superior to the AP. Surgeons engaged in parotidectomy should be familiar with both methods of dissection.
https://ift.tt/2rHy8oY
The multiplanar analysis of the retromandibular vein in surgical planning for parotid gland tumors
Abstract
Objective
To analyze the effectiveness of the multiplanar analysis of the retromandibular vein in establishing the position of the parotid gland tumor and its relationship with the facial nerve, together with the most common radiological criteria (facial nerve line, Utrecht line, retromandibular vein and parapharyngeal space variations) using the magnetic resonance imaging.
Study design
Retrospective study
Setting
Tertiary Academic Hospital
Subjects and methods
128 preoperative magnetic resonances were analyzed to study preoperative tumor location (medial or lateral to the expected course of the facial nerve) based on comparison between the radiological criteria and the surgical findings.
Results
FN line had the lowest accuracy at 77%, whereas the retromandibular vein achieved 85% accuracy and the UT line achieved accuracy of 93%. The retromandibular vein could not be identified in 11 cases (9%). The multiplanar evaluation of the retromandibular vein allowed us to identify it on almost all MR images (99% of cases) and reach 87% of accuracy. The parapharyngeal space evaluation achieved 92% of accuracy. In the subgroup of 66 cases where the neoplasms were strictly related to the main trunk, where the surgery entailed manipulation if situated laterally to the tumor, the multiplanar evaluation of the retromandibular vein reached 98% of accuracy and UT line achieved 94%.
Conclusions
The multiplanar modality, combined with the evaluation of the parapharyngeal space, is effective in helping the surgeon to achieve accurate planning: it enables the tumor to be located and the facial nerve course predicted with a good precision.
https://ift.tt/2rGohQe
Reducing post-tonsillectomy haemorrhage rates through a quality improvement project using a Swedish National quality register: a case study
Abstract
Purpose
Tonsillectomy (TE) is one of the most frequently performed ENT surgical procedures. Post-tonsillectomy haemorrhage (PTH) is a potentially life-threatening complication of TE. The National Tonsil Surgery Register in Sweden (NTSRS) has revealed wide variations in PTH rates among Swedish ENT centres. In 2013, the steering committee of the NTSRS, therefore, initiated a quality improvement project (QIP) to decrease the PTH incidence. The aim of the present study was to describe and evaluate the multicentre QIP initiated to decrease PTH rates.
Methods
Six ENT centres, all with PTH rates above the Swedish average, participated in the 7-month quality improvement project. Each centre developed improvement plans describing the intended changes in clinical practice. The project's primary outcome variable was the PTH rate. Process indicators, such as surgical technique, were also documented. Data from the QIP centres were compared with a control group of 15 surgical centres in Sweden with similarly high PTH rates. Data from both groups for the 12 months prior to the start of the QIP were compared with data for the 12 months after the QIP.
Results
The QIP centres reduced the PTH rate from 12.7 to 7.1% from pre-QIP to follow-up; in the control group, the PTH rate remained unchanged. The QIP centres also exhibited positive changes in related key process indicators, i.e., increasing the use of cold techniques for dissection and haemostasis.
Conclusions
The rates of PTH can be reduced with a QIP. A national quality register can be used not only to identify areas for improvement but also to evaluate the impact of subsequent improvement efforts and thereby guide professional development and enhance patient outcomes.
https://ift.tt/2wIC4Li
Effects of gadolinium-based contrast agents on submandibular gland tissue in rats
Abstract
Aim
The aim of this prospective animal study is to investigate the influence of multiple administrations of macrocyclic ionic (gadoteric acid) and linear nonionic (gadodiamide) gadolinium-based contrast agents (GBCA) on submandibular gland tissue (SGT) of the rats.
Material and method
Twenty-four Sprague Dawley female rats were included the study. Group 1 was determined as a control group (n = 6). Group 2 was determined as saline group (n = 6). Group 3 was determined as Omniscan group (n = 6) and received only intraperitoneal (IP) 0.1 mmol (0.2 mL/kg)/kg gadodiamide for 8 days. Group 4 was determined as Dotarem group (n = 6) and received only IP 0.1 mmol (0.2 mL/kg)/mg/kg gadoteric acid daily for 8 days. On the 9th day of the administration, the rats were sedated with ketamine and xylazine through IP injection. The right SGT was removed after sedation. Histopathological and immunohistochemical changes in SGT were evaluated.
Results
The SGT of the Omniscan and Dotarem groups decreased SGT acini surface area, and serous acinar cells number were observed. On the other hand, no pathology was observed. Mucous acinar cells' caspase-3 positivity for the same markers in Omniscan and Dotarem sections was similar to the control group. However, Omniscan and Dotarem groups serous acinar cells were caspase-3 (+) staining. The intensity of serous acinar cells' caspase-3 (+) for the same markers in Dotarem sections was similar to the Omniscan group. The results also revealed in the analysis of the mean area of the acinus area of the SGT; there were significantly decreased Dotarem group rats when compared to control rats (p < 0.05).
Conclusion
We consider that numerical increased apoptosis results arise from repeated doses of GBCAs. Being aware of this effect of the contrast agent may have significance for the chronic sialo-adenitis patients group when used for recurrent contrasted MRI for diagnosis of diseases like MS which requires in follow-up. We should be aware about the frequently contrasted MRI in routine investigations.
https://ift.tt/2rGojaO
Low inter-examiner agreement of the Friedman staging system indicating limited value in patient selection
Abstract
Purpose
The Friedman staging system is a clinical method for selecting patients with obstructive sleep apnoea who are likely to benefit from uvulopalatopharyngoplasty. The objective of this study was to evaluate the system by determining its inter-examiner agreement.
Methods
Twelve patients with obstructive sleep apnoea were examined by 14 doctors. The Friedman stage was derived from tonsil size and tongue position, and a Cohen's kappa analysis was performed to assess inter-examiner agreement.
Results
One hundred and sixty-eight ratings were performed. The median kappa for tongue position was 0.32 (first and third quartiles: 0.21 and 0.44) and was 0.62 (0.50 and 0.63) for tonsil size. The median kappa for the Friedman stage was 0.38 (0.24 and 0.55), which corresponds to only a slight or fair agreement.
Conclusion
The Friedman staging system demonstrated a low inter-examiner agreement, indicating that the system is an uncertain method for selecting patients for uvulopalatopharyngoplasty.
Level of evidence
2B.
https://ift.tt/2KoPazo
Cripto-1 is overexpressed in carcinoma ex pleomorphic adenoma of salivary gland
Abstract
Introduction
Cripto-1 is a member of the epidermal growth factor—Cripto-1/FRL-1/Cryptic family. Besides being critical for early embryonic development, Cripto-1 is also associated with the development and behavior of several cancers. Objective: We analyzed the immunoexpression of Cripto-1 in normal salivary glands (NSGs), pleomorphic adenomas (PAs), and carcinoma ex pleomorphic adenomas (CaExPAs) of salivary glands.
Methods
A total of 12 NSGs, 16 PAs and 12 CaExPAs underwent immunohistochemical study by the polymeric biotin-free technique. Immunopositive cells were evaluated semiquantitatively (scores 0–3). For statistical analysis, Mann–Whitney and Kruskal–Wallis tests were performed and a significance level of p ≤ 0.05 was established.
Results
Most CaExPAs (n = 10) were strong positive (score 3) for Cripto-1, and only three cases of PAs and two specimens of NSGs exhibited some expression (score 1), being statistically significant these findings (p < 0.001). No difference between the expression of this protein in tumors of major and minor salivary glands was observed. Overexpression was found mainly in cases of CaExPAs with invasive growth (n = 8) when compared to those without capsular invasion (intracapsular pattern) (p = 0.036). Patients with or without lymph node metastasis showed no difference (p = 0.294).
Conclusion
The results revealed a significantly higher expression of Cripto-1 in CaExPA compared to PA and NSG, suggesting this protein is possibly deregulated in PA malignant transformation. Furthermore, the increased expression of this protein is associated with a more aggressive behavior (invasive growth) in salivary gland tumors.
https://ift.tt/2rGye0l
Chronic inflammatory demyelinating polyneuropathy: evaluation of the vestibular system with cervical and ocular vestibular evoked myogenic potentials
Abstract
Purpose
To investigate the possibility of vestibular damage in a group of patients suffering from chronic inflammatory demyelinating polyneuropathy (CIDP) using a diagnostic protocol including the caloric test, C-VEMPs and O-VEMPs.
Methods
Twenty patients suffering from CIDP (mean age 58.5 years, range 33–80 years; 4 women and 16 men) were investigated. To assess any eventual audio-vestibular involvement, all patients of the study underwent pure tone audiometry, Fitzgerald–Hallpike caloric vestibular test, C-VEMPs and O-VEMPs.
Results
In 11 patients with CIDP values of both O-VEMPs and C-VEMPs were either absent or abnormal. An absent trace at O-VEMPs testing occurred in 36% of these pathological patients, whereas an increase of n10 latency and amplitude was present in the other 64% .
Conclusions
A specific diagnostic protocol including the caloric test, C-VEMPS, O-VEMPS, could be useful when employed for identifying vestibular damage in CIDP patients.
https://ift.tt/2rFpI1q
Fetal Type Rhabdomyoma of the Soft Palate in an Adult Patient: Report of One Case and Review of the Literature
Abstract
Rhabdomyoma is a rare benign tumor with skeletal muscle differentiation. Rhabdomyoma is further classified into cardiac, adult, fetal, and genital subtypes. Out of these, fetal type rhabdomyoma (FTR) is the rarest. Only a small number of cases have been recorded in the literature. FTR typically affects male infants and young children and occurs predominantly in the head and neck region. FTR is exceedingly rare in the adult, with less than 30 cases reported. The classic FTR is composed of primitive undifferentiated spindle cells with scant eosinophilic cytoplasm embedded in a myxoid stroma. Immunohistochemically, the tumor cells are positive for desmin, muscle specific actin, and myogenin. Awareness and proper recognition of this rare entity is of considerable importance to avoid misdiagnosis of embryonal rhabdomyosarcoma. In this study, we report one case of FTR in an adult patient and reviewed the literature about the clinical and pathologic presentation of FTR in the adult.
https://ift.tt/2wEYpJy
Fetal Type Rhabdomyoma of the Soft Palate in an Adult Patient: Report of One Case and Review of the Literature
Abstract
Rhabdomyoma is a rare benign tumor with skeletal muscle differentiation. Rhabdomyoma is further classified into cardiac, adult, fetal, and genital subtypes. Out of these, fetal type rhabdomyoma (FTR) is the rarest. Only a small number of cases have been recorded in the literature. FTR typically affects male infants and young children and occurs predominantly in the head and neck region. FTR is exceedingly rare in the adult, with less than 30 cases reported. The classic FTR is composed of primitive undifferentiated spindle cells with scant eosinophilic cytoplasm embedded in a myxoid stroma. Immunohistochemically, the tumor cells are positive for desmin, muscle specific actin, and myogenin. Awareness and proper recognition of this rare entity is of considerable importance to avoid misdiagnosis of embryonal rhabdomyosarcoma. In this study, we report one case of FTR in an adult patient and reviewed the literature about the clinical and pathologic presentation of FTR in the adult.
https://ift.tt/2wEYpJy
Fetal Type Rhabdomyoma of the Soft Palate in an Adult Patient: Report of One Case and Review of the Literature
Abstract
Rhabdomyoma is a rare benign tumor with skeletal muscle differentiation. Rhabdomyoma is further classified into cardiac, adult, fetal, and genital subtypes. Out of these, fetal type rhabdomyoma (FTR) is the rarest. Only a small number of cases have been recorded in the literature. FTR typically affects male infants and young children and occurs predominantly in the head and neck region. FTR is exceedingly rare in the adult, with less than 30 cases reported. The classic FTR is composed of primitive undifferentiated spindle cells with scant eosinophilic cytoplasm embedded in a myxoid stroma. Immunohistochemically, the tumor cells are positive for desmin, muscle specific actin, and myogenin. Awareness and proper recognition of this rare entity is of considerable importance to avoid misdiagnosis of embryonal rhabdomyosarcoma. In this study, we report one case of FTR in an adult patient and reviewed the literature about the clinical and pathologic presentation of FTR in the adult.
https://ift.tt/2wEYpJy
A Randomized Study of Palliative Radiation Therapy vs. no Palliative Radiation Therapy for Patients With High Risk Bone Metastases That Are Not Causing Significant Pain
Condition: Metastatic Solid Tumors of Metastatic Disease
Interventions: Radiation: Radiation Therapy; Drug: Systemic Therapy
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting
https://ift.tt/2wEGBOB
Interventions: Radiation: Radiation Therapy; Drug: Systemic Therapy
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting
https://ift.tt/2wEGBOB
Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinoma
Conditions: Head and Neck Squamous Cell Carcinoma; Cutaneous Squamous Cell Carcinoma; Head and Neck Cancer; Head and Neck Carcinoma
Interventions: Drug: Lenvatinib Pill; Drug: Cetuximab
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting
https://ift.tt/2IBBtQ7
Interventions: Drug: Lenvatinib Pill; Drug: Cetuximab
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting
https://ift.tt/2IBBtQ7
Retrograde jejunojejunal intussusception in a pregnant female after laparoscopic Roux-en-Y gastric bypass
Abstract
Adult intussusception is a rare complication after laparoscopic Roux-En-Y gastric bypass (LRYGB) surgery. Incidence of intussusception is on the rise as the demand of bariatric surgeries is increased to treat morbid obesity. Among the bariatric surgeries, LRYGB gastric bypass results in significantly higher weight loss with thinning of the mesentery resulting in increased risk for intussusception. Majority of intussusception cases after gastric bypass have been reported in non-pregnant patients. We report a case of retrograde jejunojejunal intussusception in 6 weeks pregnant female following laparoscopic gastric bypass, which was diagnosed with abdominal magnetic resonance imaging and managed successfully with resection and revision of the anastomosis.https://ift.tt/2rHbOv6
Haemangiopericytoma of the greater omentum: a rare tumour requiring long-term follow-up
Abstract
Haemangiopericytomas (HPC) are highly vascularized tumours located in any part of the body where capillaries can be found. Since 2002, they have been re-classified under the umbrella 'extrapleural Solitary Fibrous Tumour (SFT)' and the term HPC is nowadays used to describe a growth pattern rather than a clinical entity. Their biological behaviour varies and they require a long-term follow-up since they may recur or metastasise several years after successful treatment. We present the case of a gentleman with HPC of the greater omentum initially appeared in 1998. HPC rarely develops in the greater omentum and only 20 cases have been described in the literature till today. Despite complete excision the mass re-appeared in 2011 and 2017, 13 and 19 years after initial treatment. Surgical management included en bloc excision of three lesions along with greater omentum. No further treatment was required.https://ift.tt/2IdPBzI
Abdominal hernia and the unexpected final diagnosis
Abstract
Mucinous neoplasm of the appendix are rare entities, among these, mucinous cystadenomas contribute to 31–34%. Cystadenomas often produce extensive dilatation of the appendix with epithelial atypia. Spontaneous perforation often occurs in 20%, leading to mucin distribution throughout the peritoneal cavity. Half of the patients are completely asymptomatic and are detected as an incidental diagnosis, others symptoms include a palpable mass, hernias, weight loss, peritonism or even intestinal obstruction. We present a case of a 71-year-old female, she presented with a palpable mass in the upper abdomen. A ventral hernia was the most likely diagnosis and hernioplasty was planned. At surgery, a mucinous mass was discovered and mucous material was found free en the peritoneal cavity. Also, a perforated appendix and a mass in the cecum was found. Patient underwent full recovery. Pathology reported pseudomyxoma peritonei as the final diagnosis.https://ift.tt/2rIxuH1
Primary jejunal Burkitt lymphoma in a child: ultrasonic detection
Abstract
Gastrointestinal Burkitt lymphoma (BL) is a highly aggressive malignancy in childhood, and early treatment is critical for its favorable prognosis. Ultrasonography is a widely accepted initial imaging workup; therefore, recognition of the sonographic features of BL should contribute to its early diagnosis and initiation of treatment. We present a 4-year-old boy with primary jejunal BL with intussusception mimicking presentation, in which initial abdominal US allowed sustainable detection and characterization of the intestinal lesion. Jejunotomy was performed and histopathological analysis revealed a 'starry sky' pattern and c-myc split signals characteristic of BL. The patient remains disease-free following chemotherapy.https://ift.tt/2IeX5md
Polymorphous adenocarcinoma of the salivary glands: reappraisal and update
Abstract
Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG). This approach raised controversy, predominantly because of possible differences in clinical behaviour. For example, PLGA (PAC, classical variant) only rarely metastasizes, whereas CAMSG often shows metastases to the neck lymph nodes. Given the controversy, this review reappraises the definition, epidemiology, clinical presentation, diagnostic work-up, genetics, treatment modalities, and prognosis of PAC of the salivary glands with a particular focus on contrasting differences with CAMSG.
https://ift.tt/2rGQ7Mc
Erkennung und Vermeidung von Schwierigkeiten bei der Tränenwegschirurgie
Zusammenfassung
Die operative Versorgung der intra- und postsakkalen Tränenwegstenose gehört zu den besonders erfolgversprechenden Eingriffen des Fachgebiets. Um das Potenzial der endonasalen Dakryozystorhinostomie ganz auszuschöpfen, um Fehler in der Auswahl der Patienten, in der technischen Durchführung, aber auch in der Kommunikation mit den Kollegen der Ophthalmologie zu vermeiden, müssen einige diagnostische und differenzialindikatorische Aspekte berücksichtigt werden. Geordnet nach dem klinischen Ablauf der Patientenversorgung werden diese hier vor dem Hintergrund der aktuellen Literatur dargestellt.
https://ift.tt/2If18yS
Oncological Outcomes Following Transoral CO 2 Laser Microsurgery for T1 Glottic Cancer
Abstract
The objective of this study is to analyze oncological outcomes for treatment of Tis and T1 glottic squamous cell carcinoma after transoral laser microsurgery. This study is retrospective analysis of previously untreated, suspected lesion of glottis, staged cT1a and cT1b squamous cell carcinoma in a tertiary care hospital and 53 patients were included in the study. End points for analysis were local control, overall and disease specific survival rates. The local control, ultimate local control with laser alone, 3-year overall survival, 3-year disease specific survival and organ preservation rates were 86.7, 90.5, 92.4, 98.1 and 98.1% respectively. The involvement of anterior commissure did not show any significant impact on local control or survival. TLM is safe and effective treatment of early glottis cancer, associated with less morbidity and a high percentage of local control, survival and organ preservation rates.
https://ift.tt/2wBLJDf
Oncological Outcomes Following Transoral CO 2 Laser Microsurgery for T1 Glottic Cancer
Abstract
The objective of this study is to analyze oncological outcomes for treatment of Tis and T1 glottic squamous cell carcinoma after transoral laser microsurgery. This study is retrospective analysis of previously untreated, suspected lesion of glottis, staged cT1a and cT1b squamous cell carcinoma in a tertiary care hospital and 53 patients were included in the study. End points for analysis were local control, overall and disease specific survival rates. The local control, ultimate local control with laser alone, 3-year overall survival, 3-year disease specific survival and organ preservation rates were 86.7, 90.5, 92.4, 98.1 and 98.1% respectively. The involvement of anterior commissure did not show any significant impact on local control or survival. TLM is safe and effective treatment of early glottis cancer, associated with less morbidity and a high percentage of local control, survival and organ preservation rates.
https://ift.tt/2wBLJDf
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