Molecular Basis Behind Inability of Mitochondrial Holocytochrome c Synthase to Mature Bacterial Cytochromes: Defining a Critical Role for Cytochrome c Alpha Helix-1 Cell Biology
Mitochondrial holocytochrome c synthase (HCCS) is required for cytochrome c (cyt c) maturation and therefore respiration. HCCS efficiently attaches heme via two thioethers to CXXCH of mitochondrial but not bacterial cyt c, even though they are functionally conserved. This inability is due to residues in the bacterial cyt c N terminus, but the molecular basis… Continue reading Molecular Basis Behind Inability of Mitochondrial Holocytochrome c Synthase to Mature Bacterial Cytochromes: Defining a Critical Role for Cytochrome c Alpha Helix-1 Cell Biology
Blood concentrations of carotenoids and retinol and lung cancer risk: an update of the WCRF–AICR systematic review of published prospective studies
Abstract Carotenoids and retinol are considered biomarkers of fruits and vegetables intake, and are of much interest because of their anti-inflammatory and antioxidant properties; however, there is inconsistent evidence regarding their protective effects against lung cancer. We conducted a meta-analysis of prospective studies of blood concentrations of carotenoids and retinol, and lung cancer risk. We… Continue reading Blood concentrations of carotenoids and retinol and lung cancer risk: an update of the WCRF–AICR systematic review of published prospective studies
Leukocyte telomere length in relation to the risk of Barrett’s esophagus and esophageal adenocarcinoma
Abstract Chronic inflammation and oxidative damage caused by obesity, cigarette smoking, and chronic gastroesophageal reflux disease (GERD) are major risk factors associated with Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC). EAC has been increasing the past few decades, and early discovery and treatment are crucial for survival. Telomere shortening due to cell division and oxidative… Continue reading Leukocyte telomere length in relation to the risk of Barrett’s esophagus and esophageal adenocarcinoma
Colon cancer that has metastasized to the liver
Colon cancer that has metastasized to the liver: a metastatic (spread from its site of origin to a distant site) cancer that originated in the colon and has spread through the bloodstream to the liver. See also: colon cancer, metastasis. MedTerms (TM) is the Medical Dictionary of MedicineNet.com. We Bring Doctors’ Knowledge To You from… Continue reading Colon cancer that has metastasized to the liver
B7-H4 expression indicates poor prognosis of oral squamous cell carcinoma
Abstract Checkpoint blockade therapy utilizing monoclonal antibodies to reactivate T cells and recover their antitumor activity makes an epoch in cancer immunotherapy. The role of B7-H4, a novel negative immune checkpoint, in oral squamous cell carcinoma (OSCC) has still not been elucidated. In this study, tissue samples from human OSCC, which contains 165 primary OSCC,… Continue reading B7-H4 expression indicates poor prognosis of oral squamous cell carcinoma
Adjunctive role of MMP-9 inhibition along with conventional anti-tubercular drugs against experimental tuberculous meningitis
Summary Tuberculous meningitis (TBM) is an outcome of neuroinflammatory degeneration caused due to Mycobacterium tuberculosis infection and leads to death or neurological disabilities in the affected individuals. It causes the highest morbidity and mortality amongst all forms of tuberculosis. Matrix metalloproteinase-9 levels increase and cause inflammatory destruction during progression of the disease. Although corticosteroids are… Continue reading Adjunctive role of MMP-9 inhibition along with conventional anti-tubercular drugs against experimental tuberculous meningitis
The role of heparan sulphate in development: the ectodermal story
Summary Heparan sulphate (HS) is ubiquitously expressed and is formed of repeating glucosamine and glucuronic/iduronic acid units which are generally highly sulphated. HS is found in tissues bound to proteins forming HS proteoglycans (HSPGs) which are present on the cell membrane or in the extracellular matrix. HSPGs influence a variety of biological processes by interacting… Continue reading The role of heparan sulphate in development: the ectodermal story
Spinal Infections Among Patients With Long-Term Central Venous Catheters for Home Parenteral Nutrition: A Descriptive Case Series
Spinal infections are a rare yet serious metastatic complication of bacteremia among patients with long-term central venous catheters (CVCs) for which clinicians must remain vigilant. We performed a retrospective review of all cases of spinal infection occurring in the context of a CVC for long-term parenteral nutrition (PN) managed in our department between January 2010… Continue reading Spinal Infections Among Patients With Long-Term Central Venous Catheters for Home Parenteral Nutrition: A Descriptive Case Series
The origins and progression of CNS autoimmunity: Nature, nurture, and tumor
Neuroblastoma is the most common extracranial solid cancer of childhood, accounting for 15% of cancer deaths in children.1 A small proportion (up to 4%) of children with neuroblastoma develop opsoclonus-myoclonus ataxia syndrome (OMAS), a paraneoplastic autoimmune CNS disorder.2 Of note, neuroblastoma associated with OMAS is frequently of low stage, incurring a better prognosis,3 suggesting that… Continue reading The origins and progression of CNS autoimmunity: Nature, nurture, and tumor
Multiphase CT angiography increases detection of anterior circulation intracranial occlusion
Objective: To evaluate whether the use of multiphase CT angiography (CTA) improves interrater agreement for intracranial occlusion detection between stroke neurology trainees and an expert neuroradiologist. Methods: A neuroradiologist and 2 stroke neurology fellows independently reviewed 100 prospectively collected single-phase and multiphase CTA scans from acute ischemic stroke patients with mild symptoms (NIH Stroke Scale… Continue reading Multiphase CT angiography increases detection of anterior circulation intracranial occlusion
Atypia of Undetermined Significance on Thyroid Fine Needle Aspiration – Risk Factors for Malignancy
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Atypia of Undetermined Significance on Thyroid Fine Needle Aspiration – Risk Factors for Malignancy: Abstract Objectives This study is designed to determine the clinical predictors of malignancy in the atypia of undetermined significance (AUS) category resulted from thyroid fine needle aspiration (FNA). Design Retrospective cohort study. Setting Dong-A University Medical Center, Busan, Korea. Participants Sixty-two […]
Thiol/Disulfide Homeostasis in Bell’s Palsy as a Novel Pathogenetic Marker
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Thiol/Disulfide Homeostasis in Bell’s Palsy as a Novel Pathogenetic Marker: Abstract Objective The aim of this study was to investigate the relationship between Bell’s palsy and a novel oxidative stress parameter, thiol/disulphide homeostasis Design and Setting Totally 77 patients with Bell’s palsy and 38 healthy controls were included in this study. The blood levels of […]
Domestic Dog Exposure at birth reduces the Incidence of Atopic Dermatitis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Domestic Dog Exposure at birth reduces the Incidence of Atopic Dermatitis: Abstract Background While the etiopathogenesis of atopic dermatitis is complex and poorly understood, neonatal exposures are important for disease occurrence. However, the effect of dog exposure on the risk of atopic dermatitis is unresolved. Objective We investigated whether domestic dog exposure affected the risk […]
Glutamate Neurotransmission in Rodent Models of Traumatic Brain Injury
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Journal of Neurotrauma , Vol. 0, No. 0. } http://ift.tt/29nDH6g
Vestibular Dysfunction after Subconcussive Head Impact
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Journal of Neurotrauma , Vol. 0, No. 0. } http://ift.tt/29piUv6
White Matter Changes and Confrontation Naming in Retired Aging National Football League Athletes
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Journal of Neurotrauma , Vol. 0, No. 0. } http://ift.tt/29nDDn2
Comprehensive Profiling of Modulation of Nitric Oxide Levels and Mitochondrial Activity in the Injured Brain: An Experimental Study Based on the Fluid Percussion Injury Model in Rats
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Journal of Neurotrauma , Vol. 0, No. 0. } http://ift.tt/29pivsj
B7-H4 expression indicates poor prognosis of oral squamous cell carcinoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Abstract Checkpoint blockade therapy utilizing monoclonal antibodies to reactivate T cells and recover their antitumor activity makes an epoch in cancer immunotherapy. The role of B7-H4, a novel negative immune checkpoint, in oral squamous cell carcinoma (OSCC) has still not been elucidated. In this study, tissue samples from human OSCC, which contains 165 primary OSCC, […]
Adjunctive role of MMP-9 inhibition along with conventional anti-tubercular drugs against experimental tuberculous meningitis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Summary Tuberculous meningitis (TBM) is an outcome of neuroinflammatory degeneration caused due to Mycobacterium tuberculosis infection and leads to death or neurological disabilities in the affected individuals. It causes the highest morbidity and mortality amongst all forms of tuberculosis. Matrix metalloproteinase-9 levels increase and cause inflammatory destruction during progression of the disease. Although corticosteroids are […]
The role of heparan sulphate in development: the ectodermal story
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Summary Heparan sulphate (HS) is ubiquitously expressed and is formed of repeating glucosamine and glucuronic/iduronic acid units which are generally highly sulphated. HS is found in tissues bound to proteins forming HS proteoglycans (HSPGs) which are present on the cell membrane or in the extracellular matrix. HSPGs influence a variety of biological processes by interacting […]
ERCC3-MYC interactions as target in pancreatic cancer
Purpose: Even when diagnosed prior to metastasis, pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with almost 90% lethality, emphasizing the need for new therapies optimally targeting the tumors of individual patients. Experimental Design:We first developed a panel of new physiological models for study of PDAC, expanding surgical PDAC tumor samples in culture using short-term culture and conditional reprogramming with the Rho kinase inhibitor Y-27632, and creating matched patient-derived xenografts (PDX). These were evaluated for sensitivity to a large panel of... περισσότερα »
Coexistent Supratentorial and Infratentorial Subdural Hygromas with Hydrocephalus After Chiari Decompression Surgery: Review of Literature
[image: S18788750.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): G. Lakshmi Prasad, Girish R. Menon BackgroundForamen magnum decompression (FMD) is the standard procedure for Chiari I malformation. Although seemingly a straightforward procedure, recent articles have reported an increase in various complications. We describe a rare complication of coexistent supratentorial and infratentorial subdural hygromas (SDHs) with hydrocephalus noted after FMD and provide a detailed review of the literature on this topic.MethodsA 34-year-old woman prese... περισσότερα »
Mild Traumatic Brain Injury in Patients on Long-Term Anticoagulation Therapy: Do They Really Need Repeated Head CT Scan?
Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Laura Uccella, Cesare Zoia, Francesco Perlasca, Daniele Bongetta, Roberta Codecà, Paolo Gaetani BackgroundMild traumatic brain injury (mTBI), defined as blunt trauma to the head resulting in witnessed loss of consciousness, definite amnesia, or witnessed disorientation with a Glasgow Coma Scale (GCS) score of 14 or 15 is a common occurrence in the emergency department. In mTBI, oral anticoagulation is known to be an important risk factor for hemorrhage. Clinical guidelines recommend baseline computed ... περισσότερα »
Bracing After Surgical Stabilization of Thoracolumbar Fractures: A Systematic Review of Evidence, Indications, and Practices
[image: S18788750.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Jesse Skoch, Carmine Zoccali, Orel Zaninovich, Nikolay Martirosyan, Christina M. Walter, Philip Maykowski, Ali A. Baaj BackgroundThe role of spinal orthotic braces after surgical stabilization is not clearly defined. We systematically reviewed the published literature to determine patterns of practice, indications, and current evidence for the use of orthotic braces after surgical thoracolumbar fracture stabilization.MethodsA search was performed for publications including descr... περισσότερα »
Intraoperative Ultrasound Technology in Neuro-Oncology Practice—Current Role and Future Applications
[image: alertIcon.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Aliasgar V. Moiyadi BackgroundSurgery for cranial and spinal tumors has evolved tremendously over the years. Not only have neuro-oncologists been able to better understand tumor biology and thereby improve multimodality therapy, but advances in surgical techniques have also directly equipped neurosurgeons with the armamentarium necessary to achieve more radical resections safely. Intraoperative imaging tools are one such adjunct. Though intraoperative magnetic resonance (MR) has... περισσότερα »
Cortical Entropy, Mutual Information and Scale-Free Dynamics in Waking Mice
Some neural circuits operate with simple dynamics characterized by one or a few well-defined spatiotemporal scales (e.g. central pattern generators). In contrast, cortical neuronal networks often exhibit richer activity patterns in which all spatiotemporal scales are represented. Such "scale-free" cortical dynamics manifest as cascades of activity with cascade sizes that are distributed according to a power-law. Theory and *in vitro* experiments suggest that information transmission among cortical circuits is optimized by scale-free dynamics. *In vivo* tests of this hypothesis hav... περισσότερα »
Foxp2 Regulates Identities and Projection Patterns of Thalamic Nuclei During Development
The molecular mechanisms underlying the formation of the thalamus during development have been investigated intensively. Although transcription factors distinguishing the thalamic primordium from adjacent brain structures have been uncovered, those involved in patterning inside the thalamus are largely unclear. Here, we show that Foxp2, a member of the forkhead transcription factor family, regulates thalamic patterning during development. We found a graded expression pattern of Foxp2 in the thalamic primordium of the mouse embryo. The expression levels of Foxp2 were high in the po... περισσότερα »
B7-H4 expression indicates poor prognosis of oral squamous cell carcinoma
Abstract Checkpoint blockade therapy utilizing monoclonal antibodies to reactivate T cells and recover their antitumor activity makes an epoch in cancer immunotherapy. The role of B7-H4, a novel negative immune checkpoint, in oral squamous cell carcinoma (OSCC) has still not been elucidated. In this study, tissue samples from human OSCC, which contains 165 primary OSCC, 48 oral epithelial dysplasia and 43 normal oral mucosa specimens, and *Tgfbr1*/ *Pten* 2cKO mice OSCC model were stained with B7-H4 antibody to analyze the correlations between B7-H4 expression and clinicopathologica... περισσότερα »
Adjunctive role of MMP-9 inhibition along with conventional anti-tubercular drugs against experimental tuberculous meningitis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Summary Tuberculous meningitis (TBM) is an outcome of neuroinflammatory degeneration caused due to Mycobacterium tuberculosis infection and leads to death or neurological disabilities in the affected individuals. It causes the highest morbidity and mortality amongst all forms of tuberculosis. Matrix metalloproteinase-9 levels increase and cause inflammatory destruction during progression of the disease. Although corticosteroids are […]
The role of heparan sulphate in development: the ectodermal story
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Summary Heparan sulphate (HS) is ubiquitously expressed and is formed of repeating glucosamine and glucuronic/iduronic acid units which are generally highly sulphated. HS is found in tissues bound to proteins forming HS proteoglycans (HSPGs) which are present on the cell membrane or in the extracellular matrix. HSPGs influence a variety of biological processes by interacting […]
Spinal Infections Among Patients With Long-Term Central Venous Catheters for Home Parenteral Nutrition: A Descriptive Case Series
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Spinal infections are a rare yet serious metastatic complication of bacteremia among patients with long-term central venous catheters (CVCs) for which clinicians must remain vigilant. We performed a retrospective review of all cases of spinal infection occurring in the context of a CVC for long-term parenteral nutrition (PN) managed in our department between January 2010 […]
The origins and progression of CNS autoimmunity: Nature, nurture, and tumor
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Neuroblastoma is the most common extracranial solid cancer of childhood, accounting for 15% of cancer deaths in children.1 A small proportion (up to 4%) of children with neuroblastoma develop opsoclonus-myoclonus ataxia syndrome (OMAS), a paraneoplastic autoimmune CNS disorder.2 Of note, neuroblastoma associated with OMAS is frequently of low stage, incurring a better prognosis,3 suggesting that […]
Multiphase CT angiography increases detection of anterior circulation intracranial occlusion
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Objective: To evaluate whether the use of multiphase CT angiography (CTA) improves interrater agreement for intracranial occlusion detection between stroke neurology trainees and an expert neuroradiologist. Methods: A neuroradiologist and 2 stroke neurology fellows independently reviewed 100 prospectively collected single-phase and multiphase CTA scans from acute ischemic stroke patients with mild symptoms (NIH Stroke Scale […]
Spontaneous limb withdrawal heralding hyperacute stroke or stroke worsening
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Abnormal movements are infrequent presentations in acute stroke.1 However, 3 main presentations have been described as being specific to an acute stroke: limb-shaking, hemichorea-hemiballism, and unilateral asterixis.1 We report an abnormal movement that reminds us of a spontaneous limb withdrawal in 3 patients with hyperacute stroke and stroke worsening. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader […]
New insights into the neural basis of functional movement disorders
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Functional movement disorders (FMDs) encompass a broad range of abnormal movements (e.g., tremor, dystonia, myoclonus, and parkinsonism) that are clinically inconsistent with known neurologic diseases. Although they account for 16% of new referrals to neurology clinics,1 the pathophysiology of FMDs is poorly understood. In addition, FMDs represent a serious challenge for clinicians in terms of […]
Value of patient-reported symptoms in the diagnosis of transient loss of consciousness
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Objective: Epileptic seizures, syncope, and psychogenic nonepileptic seizures (PNES) account for over 90% of presentations with transient loss of consciousness (TLOC). The patient’s history is crucial for the diagnosis, but the diagnostic value of individual semiologic features is limited. This study explores the diagnostic potential of a comprehensive questionnaire focusing on TLOC-associated symptoms. Methods: A […]
Multiple sequential antibody-associated syndromes with a recurrent mutated neuroblastoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
A 5-year-old girl was diagnosed with opsoclonus-myoclonus syndrome (OMS) and a para-aortic neuroblastoma (NB) (figure 1A). Urinary catecholamines were elevated; NB biopsy confirmed no MYCN gene amplification. Serum showed Hu antibodies without hippocampal neuron surface antibodies (NSAbs) (figure 1B) and, of note, serum inhibited proliferation of cultured NB cells (figure 1C). After partial resection and […]
Type 2 diabetes mellitus is associated with brain atrophy and hypometabolism in the ADNI cohort
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Objective: We investigated type 2 diabetes mellitus (T2DM) as a risk factor for brain atrophy and glucose hypometabolism in older adults with or at risk of cognitive impairment. Methods: Participants with the T2DM were identified from the Alzheimer’s Disease Neuroimaging Initiative (ADNI-1/GO/2 cohorts). Analysis of covariance models were used to compare participants with and without […]
Aggressive solitary intracranial metastatic malignant melanoma from a primary mediastinal tumour
Malignant melanoma is the third most common tumour to cause cerebral metastases, following breast and lung cancer. Central nervous system metastases occur in 10–40% of patients with melanoma. Intracranial metastasis from a primary malignant melanoma of the anterior mediastinum is uncommon. We report a case of solitary intracranial metastatic melanoma arising from a primary mediastinal tumour. We then discuss the clinico-radiological features and treatment options. from Melanoma via xlomafota13 on Inoreader http://ift.tt/29pdQqp
Perceived Odor-Taste Congruence Influences Intensity and Pleasantness Differently
The role of congruence in cross-modal interactions has received little attention. In most experiments involving cross-modal pairs, congruence is conceived of as a binary process according to which cross-modal pairs are categorized as perceptually and/or semantically matching or mismatching. The present study investigated whether odor–taste congruence can be perceived gradually and whether congruence impacts other facets of subjective experience, that is, intensity, pleasantness, and familiarity. To address these questions, we presented food odorants (chicken, orange, and 3 mixture... περισσότερα »
Selenium and Prostate Cancer: Analysis of Individual Participant Data From Fifteen Prospective Studies
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background: Some observational studies suggest that a higher selenium status is associated with a lower risk of prostate cancer but have been generally too small to provide precise estimates of associations, particularly by disease stage and grade. Methods: Collaborating investigators from 15 prospective studies provided individual-participant records (from predominantly men of white European ancestry) on […]
NCI launches largest-ever study of breast cancer genetics in black women
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The Breast Cancer Genetic Study in African-Ancestry Populations initiative is a collaborative research project that will identify genetic factors that may underlie breast cancer disparities. It is the largest study ever to investigate how genetic and biological factors contribute to breast cancer risk among black women from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29tAmPy via IFTTT […]
A Review of 2016’s Top Ten Illusions of the Year
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Last week you chose the winners of the 12th annual Best Illusion of the Year Contest. Many of you have wondered how the illusions work, and what they tell us about our brains. I discuss each of the…
Undiagnosed aortic dissection in patient with intra-aortic balloon pump
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Monish S Raut, Arun Maheshwari, Manish Sharma Annals of Cardiac Anaesthesia 2016 19(3):549-550 60 years old lady presented with chest pain and was admitted in local hospital. Electrocardiogram was suggestive of anterior myocardial ischemia. Patient underwent coronary angiography which revealed severe triple vessles coronary artery disease. As patient was hemodynamically unstable and in cardiogenic shock, […]
Transesophageal echocardiography for minimally invasive cardiac surgery-atrial septal defect closure
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Pawan Kumar Jain, Vishwas Malik, Poonam Malhotra Kapoor Annals of Cardiac Anaesthesia 2016 19(3):527-529 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29ttotC via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Dilemma with the route of venous access for hemodialysis catheter insertion in a patient with dilated ischemic cardiomyopathy treated by cardiac resynchronization therapy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Devanahalli Ashokananda, Murali Chakravarthy, Mohan Gowda, Pavani Maddirala, Sanjay Sripar Annals of Cardiac Anaesthesia 2016 19(3):389-391 A 68 year old patient requiring urgent dialysis due to raising potassium was referred to our center. He had 3 indwelling catheters in his heart via right subclavian vein. His left subclavian and interngal jugular veins were thrombosed possibly […]
Simulation in cardiac critical care: New times and new solutions
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Poonam Malhotra Kapoor, Kalpana Irpachi Annals of Cardiac Anaesthesia 2016 19(3):385-388 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29ttHou via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Should cerebral oximetry be used as routine monitoring for cardiovascular surgical cases?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Rajinder Singh Rawat Annals of Cardiac Anaesthesia 2016 19(3):392-393 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29AcnAV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Simulation in critical care
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Ira Dhawan, Poonam Malhotra Kapoor, Arindam Choudhury Annals of Cardiac Anaesthesia 2016 19(3):537-538 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29ttQIn via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Effect of dexmedetomidine on diseased coronary vessel diameter and myocardial protection in percutaneous coronary interventional patients
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Tanveer Singh Kundra, PS Nagaraja, Naveen G Singh, Manasa Dhananjaya, N Sathish, N Manjunatha Annals of Cardiac Anaesthesia 2016 19(3):394-398 Introduction: Dexmedetomidine is an alpha-2 agonist used for conscious sedation. It has also been shown to have a myocardial protective effect in off-pump coronary artery bypass patients. The aim of the study was to assess […]
Representing multiple object weights: competing priors and sensorimotor memories.
When lifting an object, individuals scale lifting forces based on long-term priors relating external object properties (such as material and size) to object weight. When experiencing objects that are poorly predicted by priors, people rapidly form and update sensorimotor memories that can be used to predict an object's atypical size-weight relation in support of predictively scaling lift forces. With extensive experience lifting such objects, long-term priors, assessed using weight judgements, are gradually updated. The aim of the current study was to understand the formation and ... περισσότερα »
Membrane potential resonance frequency directly influences network frequency through electrical coupling
Oscillatory networks often include neurons that membrane potential resonance, a peak in the voltage amplitude as a function of current input at a nonzero (resonance) frequency (fres). Although fres has been correlated to the network frequency (fnet) in a variety of systems, a causal relationship between the two has not been established. We examine the hypothesis that combinations of biophysical parameters that shift fres, without changing other attributes of the impedance profile, also shift fnet in the same direction. We test this hypothesis, computationally and experimentally, i... περισσότερα »
Integration of autopatching with automated pipette and cell detection in vitro
Patch-clamp is the main technique for measuring electrical properties of individual cells. Since its discovery in 1976 by Neher and Sakmann, patch clamp has been instrumental in broadening our understanding of the fundamental properties of ion channels and synapses in neurons. The conventional patch-clamp method requires manual, precise positioning of a glass micropipette against the cell membrane of a visually-identified target neuron. Subsequently, a tight "giga-seal" connection between the pipette and the cell membrane is established, and suction is applied to establish the who... περισσότερα »
Glutamatergic drive facilitates synaptic inhibition of dorsal vagal motor neurons after experimentally-induced diabetes in mice
The role of central regulatory circuits in modulating diabetes-associated glucose dysregulation has only recently been under rigorous investigation. One brain region of interest is the dorsal motor nucleus of the vagus (DMV), which contains preganglionic parasympathetic motor neurons that regulate subdiaphragmatic visceral function. Previous research demonstrated that glutamatergic and GABAergic neurotransmission are independently remodeled after chronic hyperglycemia/hypoinsulinemia. However, glutamatergic circuitry within the dorsal brainstem impinges on GABAergic regulation of ... περισσότερα »
Contribution of intra-vestibular sensory conflict to motion sickness and dizziness in migraine disorders
Migraine is associated with enhanced motion sickness susceptibility and can cause episodic vertigo (vestibular migraine, VM), but the mechanisms relating migraine to these vestibular symptoms remain uncertain. We tested the hypothesis that the central integration of rotational cues (from the semicircular canals) and gravitational cues (from the otolith organs) is abnormal in migraine patients. A post-rotational tilt paradigm generated a conflict between the canal cues (which indicate the head is rotating) and the otolith cues (which indicate the head is tilted and stationary), and ... περισσότερα »
Oculomotor inhibition covaries with conscious detection
Saccadic eye movements occur frequently even during attempted fixation, but they halt momentarily when a new stimulus appears. Here we demonstrate that this rapid, involuntary "oculomotor freezing" reflex is yoked to fluctuations in explicit visual perception. Human observers reported the presence or absence of a brief visual stimulus while we recorded microsaccades, small spontaneous eye movements. We found that microsaccades were reflexively inhibited if and only if the observer reported seeing the stimulus, even when none was present. By applying a novel Bayesian classification... περισσότερα »
Optimal visuo-tactile integration for velocity discrimination of self-hand movements
Illusory hand movements can be elicited by a textured disk or a visual pattern rotating under one's hand, while proprioceptive inputs convey immobility information (Blanchard et al., 2013). Here we investigated whether visuo-tactile integration can optimize velocity discrimination of illusory hand movements in line with Bayesian predictions. We induced illusory movements in fifteen volunteers by visual and/or tactile stimulation, delivered at six angular velocities. The participants had to compare hand illusion velocities with a 5°/s hand reference movement in an alternative force... περισσότερα »
Spontaneous activity and functional connectivity in the developing cerebellorubral system
The development of the cerebellar system depends in part upon the emergence of functional connectivity in its input and output pathways. Characterization of spontaneous activity within these pathways provides insight into their functional status in early development. Here we recorded extracellular activity from the interpositus nucleus (IP) and its primary downstream target, the red nucleus (RN), in unanesthetized rats at postnatal days (P) 8 and P12, a period of dramatic change in cerebellar circuitry. The two structures exhibited state-dependent activity patterns and age-related... περισσότερα »
The compensatory interaction between motor unit firing behavior and muscle force during fatigue
Throughout the literature different observations of motor unit firing behavior during muscle fatigue have been reported and explained with varieties of conjectures. The disagreement amongst previous studies has resulted in part from the limited number of available motor units, and from the misleading practice of grouping motor unit data across different subjects, contractions, and force levels. To establish a more clear understanding of motor unit control during fatigue we investigated the firing behavior of motor units from the Vastus Lateralis muscle of individual subjects durin... περισσότερα »
Cognitive dysfunction in Duchenne Muscular Dystrophy: a possible role for neuromodulatory immune molecules.
Duchenne Muscular Dystrophy (DMD) is an X chromosome-linked disease characterized by progressive physical disability, immobility and premature death in affected boys. Underlying the devastating symptoms of DMD is the loss of dystrophin, a structural protein which connects the extracellular matrix to the cell cytoskeleton and provides protection against contraction-induced damage in muscle cells, leading to chronic peripheral inflammation. However, dystrophin is also expressed in neurons within specific brain regions, including the hippocampus, a structure associated with learning ... περισσότερα »
Pre-saccadic motion integration * between current and future retinotopic locations of attended objects
Object tracking across eye movements is thought to rely on pre-saccadic updating of attention between the object's current and its "remapped" location (i.e., the post-saccadic retinotopic location). Here we report evidence for a bi-focal, pre-saccadic sampling between these two positions. While preparing a saccade, participants viewed four spatially separated random dot kinematograms, one of which was cued by a colored flash. They reported the direction of a coherent motion signal at the cued location while a second signal occurred simultaneously either at the cue's remapped locat... περισσότερα »
Model-based stability assessment of ventilatory control in overweight adolescents with obstructive sleep apnea during NREM sleep
Obstructive sleep apnea (OSA) involves the interplay of several different factors such as an unfavorable upper airway anatomy, deficiencies in pharyngeal muscle responsiveness, a low arousal threshold, and ventilatory control instability. Although the stability of ventilatory control has been extensively studied in adults, little is known about its characteristics in the pediatric population. In this study, we developed a novel experimental setup that allowed us to perturb the respiratory system during natural non-rapid eye movement (NREM) sleep conditions by manipulating the insp... περισσότερα »
Effect of eccentric exercise with reduced muscle glycogen on plasma interleukin-6 and neuromuscular responses of musculus quadriceps femoris
Eccentric exercise can result in muscle damage and interleukin-6 (IL-6) secretion. Glycogen availability is a potent stimulator of IL-6 secretion. We examined effects of eccentric exercise in a low-glycogen state on neuromuscular function and plasma IL-6 secretion. Twelve active men (23 ± 4 yr, 179 ± 5 cm, 77 ± 10 kg, means ± SD) completed two downhill treadmill runs (gradient, –12%, 5 x 8 min; speed, 12.1 ± 1.1 km/h) with normal (NG) and reduced muscle glycogen (RG) in randomized order and at least 6 wk apart. Muscle glycogen was reduced using an established cycling protocol unti... περισσότερα »
Role of histidyl dipeptides in contractile function of fast and slow motor units in rat skeletal muscle
The physiological role of the muscle histidyl dipeptides carnosine and anserine in contractile function of various types of muscle fibers in vivo is poorly understood. Ten adult male Wistar rats were randomly assigned to two groups: control and supplemented for 10 wk with beta-alanine, the precursor of carnosine (~640 mg·kg body wt–1·day–1). Thereafter, contractile properties and fatigability of isolated fast fatigable (FF), fast resistant to fatigue (FR), and slow motor units (MUs) from the medial gastrocnemius were determined in deeply anaesthetized animals. The fatigue resistan... περισσότερα »
Separate and combined effects of a 10-d exposure to hypoxia and inactivity on oxidative function in vivo and mitochondrial respiration ex vivo in humans
An integrative evaluation of oxidative metabolism was carried out in 9 healthy young men (age, 24.1 ± 1.7 yr mean ± SD) before (CTRL) and after a 10-day horizontal bed rest carried out in normoxia (N-BR) or hypoxia (H-BR, FiO2 = 0.147). H-BR was designed to simulate planetary habitats. Pulmonary O 2 uptake (Vo2) and vastus lateralis fractional O2 extraction (changes in deoxygenated hemoglobin+myoglobin concentration, [deoxy(Hb+Mb)] evaluated using near-infrared spectroscopy) were evaluated in normoxia and during an incremental cycle ergometer (CE) and one-leg knee extension (KE) exe... περισσότερα »
Voluntary physical activity abolishes the proliferative tumor growth microenvironment created by adipose tissue in animals fed a high fat diet
The molecular mechanisms behind the obesity-breast cancer association may be regulated via adipokine secretion by white adipose tissue. Specifically, adiponectin and leptin are altered with adiposity and exert antagonistic effects on cancer cell proliferation. We set out to determine whether altering adiposity in vivo via high fat diet (HFD) feeding changed the tumor growth supporting nature of adipose tissue and whether voluntary physical activity (PA) could ameliorate these HFD-dependent effects. We show that conditioned media (CM) created from the adipose tissue of HFD fed anim... περισσότερα »
Neither load nor systemic hormones determine resistance training-mediated hypertrophy or strength gains in resistance-trained young men
We reported, using a unilateral resistance training (RT) model, that training with high or low loads (mass per repetition) resulted in similar muscle hypertrophy and strength improvements in RT-naïve subjects. Here we aimed to determine whether the same was true in men with previous RT experience using a whole-body RT program and whether postexercise systemic hormone concentrations were related to changes in hypertrophy and strength. Forty-nine resistance-trained men (23 ± 1 yr, mean ± SE) performed 12 wk of whole-body RT. Subjects were randomly allocated into a higher-repetition ... περισσότερα »
Comparison of high-intensity vs. high-volume resistance training on the BDNF response to exercise
This study compared the acute and chronic response of circulating plasma brain-derived neurotrophic factor (BDNF) to high-intensity low-volume (HI) and low-intensity high volume (HV) resistance training. Twenty experienced resistance-trained men (23.5 ± 2.6 y, 1.79 ± 0.05 m, 75.7 ± 13.8 kg) volunteered for this study. Before the resistance training program (PRE), participants performed an acute bout of exercise using either the HI [3-5 reps; 90% of one repetition maximum (1RM)] or HV (10–12 reps; 70% 1RM) training paradigm. The acute exercise protocol was repeated after 7 wk of tr... περισσότερα »
Intraoperative Fluorescence Angiography for Head and Neck Reconstruction
Abstract Purpose of Review Reconstruction of head and neck defects that cannot be closed primarily often requires the use of complex locoregional, pedicled, or microvascular flaps. Success of the reconstruction relies on the vascular supply of these flaps to prevent major and sometimes life-threatening wound complications. Intraoperative fluorescence angiography is an emerging aspect of the field that can be used as an adjunct to other methods to identify vascular compromise before, during, and after reconstruction. Recent Findings Laser-assisted near-infrared angiography with int... περισσότερα »
Coexistent Supratentorial and Infratentorial Subdural Hygromas with Hydrocephalus After Chiari Decompression Surgery: Review of Literature
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 2 ώρες
[image: S18788750.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): G. Lakshmi Prasad, Girish R. Menon BackgroundForamen magnum decompression (FMD) is the standard procedure for Chiari I malformation. Although seemingly a straightforward procedure, recent articles have reported an increase in various complications. We describe a rare complication of coexistent supratentorial and infratentorial subdural hygromas (SDHs) with hydrocephalus noted after FMD and provide a detailed review of the literature on this topic.MethodsA 34-year-old woman prese... περισσότερα »
Bracing After Surgical Stabilization of Thoracolumbar Fractures: A Systematic Review of Evidence, Indications, and Practices
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 2 ώρες
[image: S18788750.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Jesse Skoch, Carmine Zoccali, Orel Zaninovich, Nikolay Martirosyan, Christina M. Walter, Philip Maykowski, Ali A. Baaj BackgroundThe role of spinal orthotic braces after surgical stabilization is not clearly defined. We systematically reviewed the published literature to determine patterns of practice, indications, and current evidence for the use of orthotic braces after surgical thoracolumbar fracture stabilization.MethodsA search was performed for publications including descr... περισσότερα »
Mild Traumatic Brain Injury in Patients on Long-Term Anticoagulation Therapy: Do They Really Need Repeated Head CT Scan?
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 2 ώρες
Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Laura Uccella, Cesare Zoia, Francesco Perlasca, Daniele Bongetta, Roberta Codecà, Paolo Gaetani BackgroundMild traumatic brain injury (mTBI), defined as blunt trauma to the head resulting in witnessed loss of consciousness, definite amnesia, or witnessed disorientation with a Glasgow Coma Scale (GCS) score of 14 or 15 is a common occurrence in the emergency department. In mTBI, oral anticoagulation is known to be an important risk factor for hemorrhage. Clinical guidelines recommend baseline computed ... περισσότερα »
Intraoperative Ultrasound Technology in Neuro-Oncology Practice—Current Role and Future Applications
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 2 ώρες
[image: alertIcon.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Aliasgar V. Moiyadi BackgroundSurgery for cranial and spinal tumors has evolved tremendously over the years. Not only have neuro-oncologists been able to better understand tumor biology and thereby improve multimodality therapy, but advances in surgical techniques have also directly equipped neurosurgeons with the armamentarium necessary to achieve more radical resections safely. Intraoperative imaging tools are one such adjunct. Though intraoperative magnetic resonance (MR) has... περισσότερα »
Reductions of bacterial antibiotic resistance through five biological treatment processes treated municipal wastewater
Abstract Wastewater treatment plants are hot spots for antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs). However, limited studies have been conducted to compare the reductions of ARB and ARGs by various biological treatment processes. The study explored the reductions of heterotrophic bacteria resistant to six groups of antibiotics (vancomycin, gentamicin, erythromycin, cephalexin, tetracycline, and sulfadiazine) and corresponding resistance genes (*van*A, *aac*C1, *ere*A, *amp*C, *tet*A, and *sul*I) by five bench-scale biological reactors. Results demonst... περισσότερα »
Degradation and ecotoxicity of dye Reactive Black 5 after reductive-oxidative process
Abstract This research paper describes the study of a reduction-oxidation system using commercial steel wool (Fe0) and H2O2 for degradation of the dye Reactive Black 5 and aromatic compounds in water. The reductive process alone allowed the almost complete removal of color (97 ± 1 %) after 60 min of reaction. The decrease in spectral area (*λ* = 599 nm) associated with the chromophore group indicates breakage of the azo bonds. Moreover, the significant change in UV spectra can be associated with the formation of aromatic amines. Regarding the transformation products, a spectrophot... περισσότερα »
Bethesda System Of Reporting Thyroid Cytopathology – A Study Of 100 Cases
2016-07-06T17-33-37Z *Source:* National Journal of Integrated Research in Medicine Dr Rajesh Para*. Background & Objective: Thyroid nodules are common clinical occurrence . More than 50% of the world s population harbours at least 1 thyroid nodule and the frequency of nodular thyroid diseases increases with age . It is therefore no surprise that thyroid fine needle aspiration cytology (FNAC) is one of the most commonly practiced areas in non gynaecologic cytopathology. Objective is to study cytopathology of various Thyroid lesions to Differentiate and classify them according to the ... περισσότερα »
The Association Between Arterial Oxygen Tension and Neurological Outcome After Cardiac Arrest
Therapeutic Hypothermia and Temperature Management , Vol. 0, No. 0. from Therapeutics via xlomafota13 on Inoreader http://ift.tt/29oV56z
Changes in Behavior and Blood Corticosterone Level in Male and Female Rats after Single Administration of Obestatin Fragment 1-4
Single administration of the obestatin fragment 1-4 (300 nmol/kg) to male Wistar rats produced a significant weight loss in male rats on observation days 5-8, while in female rats only on day 8. In addition, males demonstrated decreased risk factor in the elevated plus-maze test, but no effect of the preparation on behavior of female… Continue reading Changes in Behavior and Blood Corticosterone Level in Male and Female Rats after Single Administration of Obestatin Fragment 1-4
The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion
Abstract Innate immune responses by myeloid cells decisively contribute to perpetuation of central nervous system (CNS) autoimmunity and their pharmacologic modulation represents a promising strategy to prevent disease progression in Multiple Sclerosis (MS). Based on our observation that peripheral immune cells from relapsing-remitting and primary progressive MS patients exhibited strongly decreased levels of the bile… Continue reading The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion
Autophagy and Immune Senescence
With extension of the average lifespan, aging has become a heavy burden in society. Immune senescence is a key risk factor for many age-related diseases such as cancer and increased infections in the elderly, and hence has elicited much attention in recent years. As our body’s guardian, the immune system maintains systemic health through removal… Continue reading Autophagy and Immune Senescence
Dopamine D3 receptors modulate the rate of neuronal recovery, cell recruitment in Area X, and song tempo after neurotoxic damage in songbirds
Publication date: 7 September 2016 Source:Neuroscience, Volume 331 Author(s): Kristina Lukacova, Eva Pavukova, Lubor Kostal, Boris Bilcik, Lubica Kubikova Songbirds, like humans, learn vocalizations and their striatum recruits new neurons in adulthood. Injury in striatal vocal nucleus Area X, involved in song learning and production in songbirds, is followed by massive regeneration. The newborn neurons… Continue reading Dopamine D3 receptors modulate the rate of neuronal recovery, cell recruitment in Area X, and song tempo after neurotoxic damage in songbirds
Hydrogen peroxide modulates neuronal excitability and membrane properties in ventral horn neurons of the rat spinal cord
Publication date: 7 September 2016 Source:Neuroscience, Volume 331 Author(s): Masayuki Ohashi, Toru Hirano, Kei Watanabe, Hirokazu Shoji, Nobuko Ohashi, Hiroshi Baba, Naoto Endo, Tatsuro Kohno Hydrogen peroxide (H2O2), a reactive oxygen species, is an important signaling molecule for synaptic and neuronal activity in the central nervous system; it is produced excessively in brain ischemia and… Continue reading Hydrogen peroxide modulates neuronal excitability and membrane properties in ventral horn neurons of the rat spinal cord
Increased apoptosis and abnormal visual behavior by histone modifications with exposure to para-xylene in developing Xenopus
Publication date: 7 September 2016 Source:Neuroscience, Volume 331 Author(s): Juanmei Gao, Hangze Ruan, Xianjie Qi, Xia Guo, Jingna Zheng, Cong Liu, Yanxiao Fang, Minjiao Huang, Miao Xu, Wanhua Shen Xylene and its derivatives are raw materials widely used in industry and known to be toxic to animals. However, the mechanism underlying the neurotoxicity of para-xylene… Continue reading Increased apoptosis and abnormal visual behavior by histone modifications with exposure to para-xylene in developing Xenopus
A support vector machine-based method to identify mild cognitive impairment with multi-level characteristics of magnetic resonance imaging
Publication date: 7 September 2016 Source:Neuroscience, Volume 331 Author(s): Zhuqing Long, Bin Jing, Huagang Yan, Jianxin Dong, Han Liu, Xiao Mo, Ying Han, Haiyun Li Mild cognitive impairment (MCI) represents a transitional state between normal aging and Alzheimer’s disease (AD). Non-invasive diagnostic methods are desirable to identify MCI for early therapeutic interventions. In this study,… Continue reading A support vector machine-based method to identify mild cognitive impairment with multi-level characteristics of magnetic resonance imaging
Loss of inhibition by brain natriuretic peptide over P2X3 receptors contributes to enhanced spike firing of trigeminal ganglion neurons in a mouse model of familial hemiplegic migraine type-1
Publication date: 7 September 2016 Source:Neuroscience, Volume 331 Author(s): Anna Marchenkova, Arn M.J.M. van den Maagdenberg, Andrea Nistri Purinergic P2X3 receptors (P2X3Rs) play an important role in pain pathologies, including migraine. In trigeminal neurons, P2X3Rs are constitutively downregulated by endogenous brain natriuretic peptide (BNP). In a mouse knock-in (KI) model of familial hemiplegic migraine type-1… Continue reading Loss of inhibition by brain natriuretic peptide over P2X3 receptors contributes to enhanced spike firing of trigeminal ganglion neurons in a mouse mod... περισσότερα »
GABAergic mechanisms contributing to categorical amygdala responses to chemosensory signals
Publication date: 7 September 2016 Source:Neuroscience, Volume 331 Author(s): Jenne M. Westberry, Michael Meredith Chemosensory stimuli from conspecific and heterospecific animals, elicit categorically different immediate-early gene response-patterns in medial amygdala in male hamsters and mice. We previously showed that conspecific signals activate posterior (MeP) as well as anterior medial amygdala (MeA), and especially relevant heterospecific… Continue reading GABAergic mechanisms contributing to categorical amygdala responses to chemosensory signals
Intraoperative Fluorescence Angiography for Head and Neck Reconstruction
Abstract Purpose of Review Reconstruction of head and neck defects that cannot be closed primarily often requires the use of complex locoregional, pedicled, or microvascular flaps. Success of the reconstruction relies on the vascular supply of these flaps to prevent major and sometimes life-threatening wound complications. Intraoperative fluorescence angiography is an emerging aspect of the… Continue reading Intraoperative Fluorescence Angiography for Head and Neck Reconstruction
Iatrogenic dissection of the descending aorta: Conservative or endovascular treatment?
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 ώρες
Nikolaos G Baikoussis, Michalis Argiriou, Theodoros Kratimenos, Vasiliki Karameri, Panagiotis Dedeilias Annals of Cardiac Anaesthesia 2016 19(3):554-556 Transcatheter aortic valve implantation (TAVI) is without any doubt a standard technique and the treatment of choice of severe aortic valve stenosis (AVS) in very high-operative risk patients. However, a number of complications may occur and has been […]
Hemodynamic challenge to early mobilization after cardiac surgery: A pilot study
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 ώρες
Tiziano Cassina, Alessandro Putzu, Luisa Santambrogio, Michele Villa, Marc Joseph Licker Annals of Cardiac Anaesthesia 2016 19(3):425-432 Background: Active mobilization is a key component in fast-track surgical strategies. Following major surgery, clinicians are often reluctant to mobilize patients arguing that circulatory homeostasis would be impaired as a result of myocardial stunning, fluid shift, and autonomic […]
Vascular airway compression management in a case of aortic arch and descending thoracic aortic aneurysm
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 ώρες
Alok Kumar, Vikas Dutta, Sunder Negi, GD Puri Annals of Cardiac Anaesthesia 2016 19(3):568-571 Airway compression due to distal aortic arch and descending aortic aneurysm repair has been documented. This case of tracheal and left main stem bronchus compression due to aortic aneurysm occurred in a 42-year-old man. The airway compression poses a challenge for […]
Anesthetic implications of subxiphoid coronary artery bypass surgery
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 ώρες
Murali Chakravarthy, Muralimanohar Veerappa, Vivek Jawali, Nischal Pandya, Jayaprakash Krishnamoorthy, Geetha Muniraju, Antony George, Jitumoni Baishya Annals of Cardiac Anaesthesia 2016 19(3):433-438 Background: Minimal invasive surgeries are carried out to benefit the patient with less pain, blood loss, mechanical ventilation and hospital stay; a smaller scar is not the aim. Minimal invasive cardiac surgeries are […]
Intraoperative Fluorescence Angiography for Head and Neck Reconstruction
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 ώρες
Abstract Purpose of Review Reconstruction of head and neck defects that cannot be closed primarily often requires the use of complex locoregional, pedicled, or microvascular flaps. Success of the reconstruction relies on the vascular supply of these flaps to prevent major and sometimes life-threatening wound complications. Intraoperative fluorescence angiography is an emerging aspect of the […]
Trigeminal Neuralgia Due to Red Vein Draining a Supratentorial Arteriovenous Malformation: Case Report
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 ώρες
J Neurol Surg Rep 2016; 77: e109-e112 DOI: 10.1055/s-0036-1584817 Trigeminal neuralgia (TGN) is rarely caused by arteriovenous malformation (AVM). The AVMs causing TGN are reported mostly in the ipsilateral posterior fossa. The culprit vessels are dilated feeding artery or nidus itself. We present a rare case of TGN caused by dilated draining veins from a […]
Trigeminal Neuralgia Due to Red Vein Draining a Supratentorial Arteriovenous Malformation: Case Report
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 ώρες
J Neurol Surg Rep 2016; 77: e109-e112 DOI: 10.1055/s-0036-1584817 Trigeminal neuralgia (TGN) is rarely caused by arteriovenous malformation (AVM). The AVMs causing TGN are reported mostly in the ipsilateral posterior fossa. The culprit vessels are dilated feeding artery or nidus itself. We present a rare case of TGN caused by dilated draining veins from a […]
Experiences and Disclosures of Sexual Assault Among Nigerian Undergraduates in a Tertiary Institution
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 ώρες
Violence and Gender , Vol. 0, No. 0. } http://ift.tt/29j37ME
Hyperinsulinism-hyperammonemia syndrome: a de novo mutation of the GLUD1 gene in twins and a review of the literature
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 ώρες
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print } http://ift.tt/29PK7Xp
Decreased undercarboxylated osteocalcin in children with type 2 diabetes mellitus
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 ώρες
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print } http://ift.tt/29o2N1P
The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion
Abstract Innate immune responses by myeloid cells decisively contribute to perpetuation of central nervous system (CNS) autoimmunity and their pharmacologic modulation represents a promising strategy to prevent disease progression in Multiple Sclerosis (MS). Based on our observation that peripheral immune cells from relapsing-remitting and primary progressive MS patients exhibited strongly decreased levels of the bile acid receptor FXR (farnesoid-X-receptor, NR1H4), we evaluated its potential relevance as therapeutic target for control of established CNS autoimmunity. Pharmacologi... περισσότερα »
Trigeminal Neuralgia Due to Red Vein Draining a Supratentorial Arteriovenous Malformation: Case Report
J Neurol Surg Rep 2016; 77: e109-e112 DOI: 10.1055/s-0036-1584817 Trigeminal neuralgia (TGN) is rarely caused by arteriovenous malformation (AVM). The AVMs causing TGN are reported mostly in the ipsilateral posterior fossa. The culprit vessels are dilated feeding artery or nidus itself. We present a rare case of TGN caused by dilated draining veins from a supratentorial AVM. The patient suffered from TGN with an incidentally found large AVM, which had been left untreated. The neuralgia was successfully relieved by microvascular decompression. Dilated red veins compressed the nerve... περισσότερα »
Juvenile Nasal Angiofibromas: A Comparison of Modern Staging Systems in an Endoscopic Era
J Neurol Surg B DOI: 10.1055/s-0036-1584903 Objectives To compare the clinical utility of four juvenile nasal angiofibroma (JNA) staging systems in a large cohort of patients. Design Retrospective case series. Setting Tertiary referral academic center. Participants Pediatric patients undergoing surgical resection of JNAs between January 2008 and June 2015. Main Outcome Measures Intraoperative blood loss and transfusions, number of staged operations, postoperative residual disease, and recurrent disease. Results In total, 34 patients were identified; all underwent preoperative embo... περισσότερα »
