Apert Syndrome
Outcomes From the Australian Craniofacial Unit's Birth to Maturity Management Protocol.: The complex, progressive, multisystem nature of Apert syndrome presents many challenges to managing surgeons. Based on the pioneering work of Paul Tessier, the senior author developed a multidisciplinary birth to maturity management protocol for Apert syndrome. Between 1975 and 2014 the Australian Craniofacial Unit has treated 174 Apert syndrome patients and 28 have completed full protocol management. This paper reviews the scientific contribution made to the management of Apert syndrome by the... περισσότερα »
Ocular Motility After Repair of Combined Medial and Inferior Orbital Wall Fractures With Extended Conjunctival Incision With Inferior Oblique Reattachment.
Ocular Motility After Repair of Combined Medial and Inferior Orbital Wall Fractures With Extended Conjunctival Incision With Inferior Oblique Reattachment.: Purpose: To describe ocular motility and effectiveness of an extended conjunctival incision with reattachment of the inferior oblique muscle to repair combined orbital medial and inferior wall fractures. Methods: The authors retrospectively studied 20 eyes from 20 patients who underwent combined orbital medial and inferior wall fractures surgery with reattachment of the inferior oblique muscle from January 2007 to December 2011.... περισσότερα »
A Cephalometric Analysis on Magnitudes and Shape of Sella Turcica.
A Cephalometric Analysis on Magnitudes and Shape of Sella Turcica.: Familiarity with the shape and dimensions of sella turcica is important to recognize and manage pathological conditions of pituitary gland as well as for orthodontic treatment planning. The present study aims to describe the morphology and dimensions of sella turcica from Indian population, using lateral cephalograms to set a reference data for comparison among different races. The study used 36 lateral skull radiographs of both sexes between age group of 13 to 18 years. Shape of sella turcica was noted by visual in... περισσότερα »
Secondary Cleft Nasal Deformity Correction Using Bioabsorbable Mesh.
Secondary Cleft Nasal Deformity Correction Using Bioabsorbable Mesh.: Introduction: Septorhinoplasty in cleft patients is relatively difficult to perform and the outcomes are often unsatisfactory owing to weakness of the cartilage. Therefore, providing support to the cartilage is necessary. The authors used bioabsorbable mesh as a spreader or batten graft to support the septum in cleft patients those with weak cartilages. The purpose of this study was to evaluate the efficacy of bioabsorbable mesh when performing septorhinoplasty in cleft patients. Methods: Between 2009 and 2013, 34... περισσότερα »
Frontalis Sling Surgery With IBCN-Ritleng Probe With a 20-Gauge Catheter.
Frontalis Sling Surgery With IBCN-Ritleng Probe: A New Technique With a 20-Gauge Catheter.: Introduction: Frontalis sling surgery is the reference procedure for severe ptosis due to poor Levator function. Autologous or synthetic materials are used for lifting the upper eyelid. Objective: To describe a new technique of passage of a silicon wire through a 20-gauge intravenous catheter and to explore literature. Methods: A 83-year-old male patient with simple, severe ptosis with previous levator resection surgery (7 month before) had frontalis sling with a silicone IBCN wire placed und... περισσότερα »
Individualized multimodal treatment strategy for anaplastic thyroid carcinoma-Case report of long-term remission and review of literature.
*Individualized multimodal treatment strategy for anaplastic thyroid carcinoma-Case report of long-term remission and review of literature.* Int J Surg Case Rep. 2016 Jun 16;25:174-178 Authors: Eckhardt S, Hoffmann S, Damanakis AI, Di Fazio P, Pfestroff A, Luster M, Wunderlich A, Bartsch DK Abstract INTRODUCTION: The prognosis of anaplastic thyroid cancer (ATC) is poor with a mean survival time of six months following diagnosis. Despite various attempts to modify common treatment modalities including surgery, external beam radiation and chemotherapy, an effective treatment is not ... περισσότερα »
Metastatic insular thyroid carcinoma masquerades as neuroendocrine tumor in lung on CT-guided fine needle aspiration biopsy
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Impact of patient age on the iodine/FDG "flip-flop" phenomenon in lung metastasis from thyroid cancer.
*Impact of patient age on the iodine/FDG "flip-flop" phenomenon in lung metastasis from thyroid cancer.* Ann Nucl Med. 2016 Jul 5; Authors: Isoda T, BaBa S, Maruoka Y, Kitamura Y, Tahara K, Sasaki M, Honda H Abstract OBJECTIVES: Radioiodine therapy is an effective treatment for lung metastasis from thyroid cancer. However, cases of lung metastasis without iodine uptake are often encountered. In such cases, FDG accumulation in lung lesions is often observed. There is a reverse relationship between iodine and FDG accumulation in thyroid cancer lesions, the so-called "flip-flop" phe... περισσότερα »
KSP inhibitor SB743921 inhibits growth and induces apoptosis of breast cancer cells by regulating p53, Bcl-2, and DTL.
*KSP inhibitor SB743921 inhibits growth and induces apoptosis of breast cancer cells by regulating p53, Bcl-2, and DTL.* Anticancer Drugs. 2016 Jul 1; Authors: Zhu L, Xiao F, Yu Y, Wang H, Fang M, Yang Y, Sun H, Wang L, Sheng Y Abstract Kinesin spindle protein (KSP) is a microtubule-associated motor protein that is specifically expressed by mitosis cells. It is highly expressed in various types of tumors including hematomalignances and solid tumors. Chemical KSP inhibition has become a novel strategy in the development of anticancer drugs. SB743921 is a selective inhibitor for KSP... περισσότερα »
Gonadal agenesis with hypoplastic paramesonephric ducts (PMNDs) derivatives in dizygotic twins.
*Gonadal agenesis with hypoplastic paramesonephric ducts (PMNDs) derivatives in dizygotic twins.* Gynecol Endocrinol. 2016 Jul 5;:1-4 Authors: Miolo G, Del Pup L, Ash A, Manno M, Pivetta B, Tessitori G, Corona G Abstract The co-occurrence of gonadal agenesis alongside hypoplastic derivatives of the paramesonephric ducts has rarely been observed. PATIENT(S): 16-year-old dizygotic twin sisters were referred to our department because of primary amenorrhea. X-ray, bone densitometry, ultrasonography, pelvic MRI and measurement of pituitary, ovary, and thyroid hormones were performed. ... περισσότερα »
Individualized multimodal treatment strategy for anaplastic thyroid carcinoma-Case report of long-term remission and review of literature.
*Individualized multimodal treatment strategy for anaplastic thyroid carcinoma-Case report of long-term remission and review of literature.* Int J Surg Case Rep. 2016 Jun 16;25:174-178 Authors: Eckhardt S, Hoffmann S, Damanakis AI, Di Fazio P, Pfestroff A, Luster M, Wunderlich A, Bartsch DK Abstract INTRODUCTION: The prognosis of anaplastic thyroid cancer (ATC) is poor with a mean survival time of six months following diagnosis. Despite various attempts to modify common treatment modalities including surgery, external beam radiation and chemotherapy, an effective treatment is not ... περισσότερα »
[Grading of neuroendocrine tumors].
*[Grading of neuroendocrine tumors].* Pathologe. 2016 Jul 5; Authors: Saeger W, Schnabel PA, Komminoth P Abstract The current WHO classification of neuroendocrine tumors (NET) differentiates between typical carcinoids (low grade NET), atypical carcinoids (intermediate grade NET) and small cell and large cell carcinomas (high grade NET) according to the prognosis. Neuroendocrine neoplasms (NEN) of the gastrointestinal tract and the pancreas are graded in an identical way. Together with the TNM system this enables a preoperative estimation of the prognosis in biopsies and fine need... περισσότερα »
Detection of Molecular Alterations in Medullary Thyroid Carcinoma Using Next-Generation Sequencing: an Institutional Experience.
*Detection of Molecular Alterations in Medullary Thyroid Carcinoma Using Next-Generation Sequencing: an Institutional Experience.* Endocr Pathol. 2016 Jul 5; Authors: Wei S, LiVolsi VA, Montone KT, Morrissette JJ, Baloch ZW Abstract Medullary thyroid carcinoma (MTC) harbors rearranged during transfection (RET) gene and rarely RAS gene mutations. The knowledge of the type of gene mutation in MTC is important to determine the treatment of the patients and the management of their family members. Targeted next-generation sequencing with a panel of 47 genes was performed in a total of ... περισσότερα »
Effects of Radioactive Iodine Ablation Therapy on Voice Quality.
*Effects of Radioactive Iodine Ablation Therapy on Voice Quality.* J Voice. 2016 Jul 1; Authors: Aydoğdu İ, Atar Y, Saltürk Z, Sarı H, Ataç E, Aydoğdu Z, İnan M, Mersinlioğlu G, Uyar Y Abstract OBJECTIVE: The goal of this study was to evaluate the effects of radioactive iodine ablation therapy on voice quality of patients diagnosed with well-differentiated thyroid carcinoma. METHODS: We enrolled 36 patients who underwent total or subtotal thyroidectomy due to well-differentiated thyroid carcinoma. Voice recordings from patients were analyzed for acoustic and aerodynamic voice. Th... περισσότερα »
[Grading of neuroendocrine tumors].
*[Grading of neuroendocrine tumors].* Pathologe. 2016 Jul 5; Authors: Saeger W, Schnabel PA, Komminoth P Abstract The current WHO classification of neuroendocrine tumors (NET) differentiates between typical carcinoids (low grade NET), atypical carcinoids (intermediate grade NET) and small cell and large cell carcinomas (high grade NET) according to the prognosis. Neuroendocrine neoplasms (NEN) of the gastrointestinal tract and the pancreas are graded in an identical way. Together with the TNM system this enables a preoperative estimation of the prognosis in biopsies and fine need... περισσότερα »
Effects of age and non-oropharyngeal proprioceptive and exteroceptive sensation on the magnitude of anticipatory mouth opening during eating.
*Effects of age and non-oropharyngeal proprioceptive and exteroceptive sensation on the magnitude of anticipatory mouth opening during eating.* J Oral Rehabil. 2016 Jul 5; Authors: Shune SE, Moon JB Abstract To best prevent and treat eating/swallowing problems, it is essential to understand how components of oral physiology contribute to the preservation and/or degradation of eating/swallowing in healthy ageing. Anticipatory, pre-swallow motor movements may be critical to safe and efficient eating/swallowing, particularly for older adults. However, the nature of these responses i... περισσότερα »
Behavioural and neurophysiological disruption of corticobulbar motor systems and their effects on sequential pharyngeal swallowing.
*Behavioural and neurophysiological disruption of corticobulbar motor systems and their effects on sequential pharyngeal swallowing.* Physiol Behav. 2016 Jul 1; Authors: Al-Toubi A, Daniels SK, Huckabee ML, Corey DM, Doeltgen SH Abstract Primary motor networks are known to be involved in the control of voluntary oral movements as well as the modulation of pharyngeal movements during experimentally controlled single swallows performed on command. The role of these networks in the more typical task of sequential swallowing remains unexplored. This study evaluated the hypothesis that... περισσότερα »
Effects of age and non-oropharyngeal proprioceptive and exteroceptive sensation on the magnitude of anticipatory mouth opening during eating.
*Effects of age and non-oropharyngeal proprioceptive and exteroceptive sensation on the magnitude of anticipatory mouth opening during eating.* J Oral Rehabil. 2016 Jul 5; Authors: Shune SE, Moon JB Abstract To best prevent and treat eating/swallowing problems, it is essential to understand how components of oral physiology contribute to the preservation and/or degradation of eating/swallowing in healthy ageing. Anticipatory, pre-swallow motor movements may be critical to safe and efficient eating/swallowing, particularly for older adults. However, the nature of these responses i... περισσότερα »
Behavioural and neurophysiological disruption of corticobulbar motor systems and their effects on sequential pharyngeal swallowing.
*Behavioural and neurophysiological disruption of corticobulbar motor systems and their effects on sequential pharyngeal swallowing.* Physiol Behav. 2016 Jul 1; Authors: Al-Toubi A, Daniels SK, Huckabee ML, Corey DM, Doeltgen SH Abstract Primary motor networks are known to be involved in the control of voluntary oral movements as well as the modulation of pharyngeal movements during experimentally controlled single swallows performed on command. The role of these networks in the more typical task of sequential swallowing remains unexplored. This study evaluated the hypothesis that... περισσότερα »
Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.
*Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.* Chem Senses. 2016 Jul 4; Authors: Untiet V, Moeller LM, Ibarra-Soria X, Sánchez-Andrade G, Stricker M, Neuhaus EM, Logan DW, Gensch T, Spehr M Abstract In rodents, the vomeronasal system controls social and sexual behavior. However, several mechanistic aspects of sensory signaling in the vomeronasal organ remain unclear. Here, we investigate the biophysical basis of a recently proposed vomeronasal signal transduction component-a Ca(2+)-activated Cl(-) current. As the physiological rol... περισσότερα »
Contour Deformities in the Frontal Bone Position.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 11 δευτερόλεπτα
Alloderm Covering Over Titanium Cranioplasty May Minimize Contour Deformities in the Frontal Bone Position.: Background: Titanium cranioplasty is commonly used for surgical closure of skull defects post craniectomy. Superficial implantation of the mesh can result in discomfort, palpability, and in extreme patients, exposure of the mesh. Exposed titanium mesh can be complicated by infections and […]
Posterior Vault Distraction Osteogenesis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 11 δευτερόλεπτα
A Perioperative Risk Comparison of Posterior Vault Distraction Osteogenesis in an Older Pediatric Population.: There is a growing literature on the advantages of posterior cranial vault distraction osteogenesis (PVDO) in infants, particularly those with syndromic and multisuture craniosynostosis. This study aims to compare perioperative outcomes of PVDO in older patients to those of infants. A […]
Post-traumatic Compound Complex Fronto-Basal Cranial Vault Fracture
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 11 δευτερόλεπτα
Single-Stage Surgical Reconstruction of Posttraumatic Compound Complex Fronto-Basal Cranial Vault Fracture in a Resource-Limited Practice.: Background: The extant literature on the surgical treatment of posttraumatic compound, complex frontal basal calvarial skull fracture suggests that this be a staged procedure. There are many socioeconomic constraints in low-resource regions of the world to the feasibility of this […]
New gene therapy protects against peanut allergy
Weill Cornell Medical College News from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29hEN28 via IFTTT
The effectiveness of 22 commonly administered physiotherapy interventions for people with spinal cord injury: A systematic review
Spinal Cord from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29iydF5 via IFTTT
Triple setup airway—simultaneous oropharyngeal, surgical, and ECMO preparation : Case report
The American Journal of Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29hFdFx via IFTTT
Treatment of acute renal colic in US and French emergency departments: Simulated cases and real cases in acute pain management
The American Journal of Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29iyTKe via IFTTT
Recurrent violent injury: magnitude, risk factors, and opportunities for intervention from a statewide analysis
The American Journal of Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29hEMLC via IFTTT
Sex-related differences in emergency department renal colic management: Females have fewer CT scans but similar outcomes
Academic Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29iy9oz via IFTTT
Pediatric clotiapine poisoning: Clinical manifestations and toxicokinetics
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Incidence, cost, complications and clinical outcomes of iatrogenic urethral catheterisation injuries: A prospective multi-institutional study
The Journal of Urology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29iywiZ via IFTTT
Intravenous and oral contrast vs intravenous contrast alone computed tomography for the visualization of appendix and diagnosis of appendicitis in adult emergency department patients
Canadian Association of Radiologists Journal from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29hEJj2 via IFTTT
Survey of parental acceptance of massage therapy, energy therapy and acupuncture for their children in the acute pediatric inpatient rehabilitation setting
Complementary Therapies in Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29ixQu2 via IFTTT
Airway obstruction and neurogenic shock due to severe cervical spine injury: a case report
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Relationship between tissue perfusion and coagulopathy in traumatic brain injury
Journal of Surgical Research from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29NSliW via IFTTT
Low-dose intravenous propofol as a possible therapeutic option for acute confusional migraine
The American Journal of Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29NTeaY via IFTTT
Echocardiographic left ventricular systolic dysfunction early after resuscitation from cardiac arrest does not predict mortality or vasopressor requirements
Resuscitation from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/29mowXW via IFTTT
Yale study: Medicaid expansion could decrease ER visits
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Muscular fitness as a mediator of quality cardiopulmonary resuscitation
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Scientists identify ways to prevent heat-related deaths from climate change
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Inhalation of a Short-Acting β2-Adrenoreceptor Agonist Induces a Hypercoagulable State in Healthy Subjects
[image: journal.pone.0158652.g001] by Mais Ali-Saleh, Galit Sarig, Jacob N. Ablin, Benjamin Brenner, Giris Jacob Background Catecholamine infusion elicits an increase in clotting factors and this increase has been attributed to stimulation of β2-adrenorecptors (β2AR). Accordingly, we tested the hypothesis that inhalation of a short-acting selective β2AR agonist can induce a procoagulant state in healthy individuals. Methods We recruited 23 healthy volunteers (nine females; mean age: 26±0.8 years; body mass index: 24.7±0.5 kg/m2) and randomly allocated them into two groups, the... περισσότερα »
Correction: A Seroepidemiological Study of Serogroup A Meningococcal Infection in the African Meningitis Belt
by Olivier Manigart, Caroline Trotter, Helen Findlow, Abraham Aseffa, Wude Mihret, Tesfaye Moti Demisse, Biruk Yeshitela, Isaac Osei, Abraham Hodgson, Stephen Laryea Quaye, Samba Sow, Mamadou Coulibaly, Kanny Diallo, Awa Traore, Jean-Marc Collard, Rahamatou Moustapha Boukary, Oumarou Djermakoye, Ali Elhaji Mahamane, Jean-François Jusot, Cheikh Sokhna, Serge Alavo, Souleymane Doucoure, El Hadj Ba, Mariétou Dieng, Aldiouma Diallo, Doumagoum Moto Daugla, Babatunji Omotara, Daniel Chandramohan, Musa Hassan-King, Maria Nascimento, Arouna Woukeu, Ray Borrow, James M. Stuart, Brian Green... περισσότερα »
Conformational Stability of the NH2-Terminal Propeptide of the Precursor of Pulmonary Surfactant Protein SP-B
[image: journal.pone.0158430.e001.PNG] by Ángeles Bañares-Hidalgo, Jesús Pérez-Gil, Pilar Estrada Assembly of pulmonary surfactant lipid-protein complexes depends on conformational changes coupled with proteolytic maturation of proSP-B, the precursor of pulmonary surfactant protein B (SP-B), along the surfactant biogenesis pathway in pneumocytes. Conformational destabilization of the N-terminal propeptide of proSP-B (SP-BN) triggers exposure of the mature SP-B domain for insertion into surfactant lipids. We have studied the conformational stability during GdmCl- or urea-promoted un... περισσότερα »
Correction: A Computerized Test of Design Fluency
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Transforming Growth Factor-β1 T869C Gene Polymorphism Is Associated with Acquired Sick Sinus Syndrome via Linking a Higher Serum Protein Level
[image: journal.pone.0158676.g002] by Jan-Yow Chen, Jiung-Hsiun Liu, Hong-Dar Isaac Wu, Kuo-Hung Lin, Kuan-Cheng Chang, Ying-Ming Liou Background Familial sick sinus syndrome is associated with gene mutations and dysfunction of ion channels. In contrast, degenerative fibrosis of the sinus node tissue plays an important role in the pathogenesis of acquired sick sinus syndrome. There is a close relationship between transforming growth factor-β1 mediated cardiac fibrosis and acquired arrhythmia. It is of interest to examine whether transforming growth factor-β1 is involved in the p... περισσότερα »
Correction: Correction: The Spread of Dengue in an Endemic Urban Milieu-The Case of Delhi, India
by The PLOS ONE Staff from Uncategorized via xlomafota13 on Inoreader http://ift.tt/29kpR1o via IFTTT
Malpighian Tubule Cells in Overwintering Cave Crickets Troglophilus cavicola (Kollar, 1833) and T. neglectus Krauss, 1879 (Rhaphidophoridae, Ensifera)
[image: journal.pone.0158598.g001] by Saška Lipovšek, Tone Novak, Franc Janžekovič, Nina Weiland, Gerd Leitinger During winter, cave cricket larvae undergo dormancy in subterranean habitats; this dormancy is termed diapause in second year *Troglophilus cavicola* larvae because they mature during this time, and termed quiescence in *T*. *neglectus*, because they mature after dormancy. Here we used electron microscopy to analyze ultrastructural changes in the epithelial cells in the Malpighian tubules (MTs) of *T*. *cavicola* during diapause, in order to compare them with previous f... περισσότερα »
Correction: The Risk of Peripheral Arterial Disease after Parathyroidectomy in Patients with End-Stage Renal Disease
by Yueh-Han Hsu, Hui-I Yu, Hsuan-Ju Chen, Tsai-Chung Li, Chih-Cheng Hsu, Chia-Hung Kao from Uncategorized via xlomafota13 on Inoreader http://ift.tt/29LDNQN via IFTTT
Emotion and Implicit Timing
[image: journal.pone.0158474.g001] by Sylvie Droit-Volet This study examined the effects of emotion on implicit timing. In the implicit timing task used, the participants did not receive any temporal instructions. Instead they were simply asked and trained to press a key as quickly as possible after a stimulus (response stimulus) that was separated from a preceding stimulus by a given temporal interval (reference interval duration). However, in the testing phase, the interval duration was the reference interval duration or a shorter or longer interval duration. In addition, the pa... περισσότερα »
Correction: A Quasi-Steady Lifting Line Theory for Insect-Like Hovering Flight
by The PLOS ONE Staff from Uncategorized via xlomafota13 on Inoreader http://ift.tt/29kpTqd via IFTTT
Predicting Endurance Time in a Repetitive Lift and Carry Task Using Linear Mixed Models
[image: journal.pone.0158418.e001.PNG] by Ben Beck, Daniel J. Ham, Stuart A. Best, Greg L. Carstairs, Robert J. Savage, Lahn Straney, Joanne N. Caldwell Objectives Repetitive manual handling tasks account for a substantial portion of work-related injuries. However, few studies report endurance time in repetitive manual handling tasks. Consequently, there is little guidance to inform expected work time for repetitive manual handling tasks. We aimed to investigate endurance time and oxygen consumption of a repetitive lift and carry task using linear mixed models. Methods Fourteen... περισσότερα »
Organisational characteristics associated with shift work practices and potential opportunities for intervention: findings from a Canadian study
Introduction Shift work is a common working arrangement with wide-ranging implications for worker health. Organisational determinants of shift work practices are not well characterised; such information could be used to guide evidence-based research and best practices to mitigate shift work's negative effects. This exploratory study aimed to describe and assess organisational-level determinants of shift work practices thought to affect health, across a range of industry sectors. Methods Data on organisational characteristics, shift work scheduling, provision of shift work educa... περισσότερα »
Wellens syndrome, a predictor of critical left anterior descending artery stenosis
An 80-year-old man with a history of atrial fibrillation and diabetes mellitus came in with bilateral lower extremity swelling and a low blood sugar of 50 mg/dL. He denied any chest pain. The troponin level was 0.4 ng/mL. An ECG was done, which showed deep T-wave inversions in V2 and V3 (figure 1). He was treated for cellulitis with antibiotics and given intravenous dextrose for low blood sugar. Given the findings on his ECG were consistent with Wellens syndrome, cardiac catheterisation was offered. He preferred to have it done at another institute where his primary cardiologist w... περισσότερα »
Bone-shaking tech inspired by hunt for gravitational waves could transform bone graft therapies
First in human trials could be just 3 years away.Scientists have designed tech to grow 3D bone in the lab without chemicals or drugs - just vibration. from Uncategorized via xlomafota13 on Inoreader http://ift.tt/29tEMIN via IFTTT
Biomarkers of Reflux Disease
The authors review the current research on biomarkers in gastroesophageal reflux disease. Is it realistic to expect to identify a single biomarker for GERD? *Clinical Gastroenterology and Hepatology* from Uncategorized via xlomafota13 on Inoreader http://ift.tt/29lPRs2 via IFTTT
New detection method paves the way for 100 percent detection of esophageal cancer
Recognizing early stages of esophageal cancer is difficult because it can easily be missed. Medical researchers have now been working to develop a method to enable a computer to scan esophagus images for signs of esophageal cancer. With exceptional results: the computer recognizes early cancer with almost as much accuracy as top specialists, of which there is only a handful. http://ift.tt/29fOzSp
Junk food advertising is too tempting for children
Children describe junk food advertising as 'tempting' and 'addictive', and say they could 'lick the screen', according to a new study that talked to children in the United Kingdom aged between 8 and 12 years. http://ift.tt/29lzHPD
Predictors of persistent pulmonary hypertension after mitral valve replacement
Abstract Persistent pulmonary hypertension (P-PH) after mitral valve replacement (MVR) leads to an increased risk of morbidity and mortality. We sought to determine which factors were involved in its occurrence. Patients undergoing MVR for a 3-year period were collected in a retrospective way. We excluded those with an available follow-up shorter than 3 months. Sample size was 111 patients. PH was diagnosed if systolic pulmonary artery pressure (sPAP) estimated by Doppler echocardiography was >40 mmHg. Clinical, echocardiographic, and surgical factors were analyzed. P-PH was prese... περισσότερα »
Indications, applications, and outcomes of inferior vena cava filters for venous thromboembolism in Japanese patients
Abstract A recent multicenter registry study of venous thromboembolism (VTE) patients in Japan demonstrated a high prevalence of inferior vena cava (IVC) filter placement. However, data regarding indications, applications, and outcomes of IVC filters in Japanese patients are quite limited. This study was an observational, single-center, retrospective cohort study of all consecutive patients with acute VTE treated between March 2006 and February 2014. Data extracted included patient demographics, indications, applications, and complications of IVC filters, as well as VTE recurrence ... περισσότερα »
A case of interferon-α-induced pulmonary arterial hypertension after living donor liver transplantation
Abstract Pulmonary arterial hypertension (PAH) is a progressive and life-threatening disease characterized by elevated pulmonary vascular resistance, which results in right-heart failure. We present a case of interferon (IFN)-α-induced PAH developed after living donor liver transplantation. Although IFN is categorized as a "possible" risk factor for PAH in the current international classification, it is still under recognized. Moreover, the prognosis of IFN-induced PAH is poor in the limited number of published cases. In our case, we achieved good outcome by the withdrawal of IFN ... περισσότερα »
Axillary artery cannulation provides balanced cerebral oxygenation
Abstract Deterioration of cerebral performance remains a major problem after cardiac surgery. Axillary artery cannulation can improve clinical outcome, but some experimental series show a malperfusion of the right hemisphere. The aim of our clinical study was to analyze the intraoperative investigation of cerebral oxygenation in two different arterial cannulation sites by use of near-infrared spectroscopic oximetry (NIRO). We compared retrospectively the cerebral saturation of 20 patients with aortic cannulation (group AoC) and 20 patients with right axillary artery cannulation (gr... περισσότερα »
Relationship between diastolic ventricular dysfunction and subclinical sleep-disordered breathing in atrial fibrillation ablation candidates
Abstract Sleep-disordered breathing (SDB) is recognized as a primary factor or mediator of atrial fibrillation (AF). We hypothesized that the severity of SDB among AF ablation candidates would be associated with left ventricular diastolic dysfunction (LVDD) even for subclinical SDB. A total of 246 patients hospitalized for initial pulmonary vein isolation (PVI) were analyzed. Known SDB cases were excluded. We measured the oxygen desaturation index (ODI) by pulse oximetry overnight as an indicator of SDB, and classified SDB severity by 3 % ODI as normal (ODI < 5 events/h), mild (OD... περισσότερα »
Linkage of sleep-disordered breathing and acute aortic dissection with patent false lumen
Abstract Sleep-disordered breathing (SDB) is known as a cardiovascular risk factor and has high prevalence in hypertension, which is a major risk factor of aortic dissection (AD). However, the impact of SDB on AD has not been fully clarified. The aim of this study is to elucidate the impact of SDB on AD, especially on the type of false lumen in AD. We enrolled twenty-three consecutive patients with acute AD (mean age: 66 ± 13 years). All subjects were evaluated by an ambulatory polygraphic sleep monitoring within 1 month from the onset. AD was evaluated by axial images of computed ... περισσότερα »
Prognostic significance of beta-blocker up-titration in conjunction with cardiac resynchronization therapy in heart failure management
Abstract Clinical practice guidelines emphasize that optimal pharmacotherapy, including beta-blockers (BB), is a prerequisite before receiving cardiac resynchronization therapy (CRT) in eligible patients with heart failure (HF). However, the optimal dose of BB before CRT implantation cannot be tolerated in a number of patients. Sixty-three consecutive patients who underwent CRT in 2006–2013 were retrospectively investigated. Before receiving CRT, BB could not be introduced in 20 patients (32 %); the daily carvedilol-equivalent dose in other 43 patients was 5.6 ± 7.0 mg because of ... περισσότερα »
Increased p -cresyl sulfate level is independently associated with poor outcomes in patients with heart failure
Abstract Amino acid-derived metabolites, including protein-bound uremic toxins, may have prognostic value for patients with heart failure (HF). The aim of this study was to investigate whether *p*-cresyl sulfate (PCS), indoxyl sulfate (IS), and arginine metabolites provided prognostic values in addition to the traditional biomarker, B-type natriuretic peptide (BNP), in patients with HF. Chromatography mass spectrometry was performed to measure tyrosine, tryptophan, arginine, PCS, IS, and asymmetric (ADMA) and symmetric dimethylarginine (SDMA) in the plasma from 51 normal controls a... περισσότερα »
Pelvic recurrence of an ovarian seromucinous borderline tumor detected by vaginal cytology: A case report and review of the literature
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Seromucinous borderline tumors are typically confined to the ovaries and rarely relapse after surgery. We report the case of a woman with a seromucinous borderline tumor with peritoneal implant at the Douglas pouch, who was affected by a recurrent tumor at the vaginal stump 2 years and 6 months after the primary surgery. The recurrent lesion was detected by vaginal cytology. Histology of the recurrent lesion showed perineural infiltration, and progression to low-grade adenocarcinoma was suggested. After the second surgery, vaginal cytology showed that the tumor cells remained pos... περισσότερα »
Metastatic insular thyroid carcinoma masquerades as neuroendocrine tumor in lung on CT-guided fine needle aspiration biopsy
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
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Cribriform neuroepithelial tumor (crinet): Molecular characterization of a smarcb1-deficient non-rhabdoid tumor with favorable long-term outcome
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Abstract Rhabdoid phenotype and loss of SMARCB1 expression in a brain tumor are characteristic features of atypical teratoid/rhabdoid tumors (ATRT). Rare non-rhabdoid brain tumors showing cribriform growth pattern and SMARCB1 loss have been designated cribriform neuroepithelial tumor (CRINET). Small case series suggest that CRINETs may have a relatively favorable prognosis. However, the long-term outcome is unclear and it remains uncertain whether CRINET represents a distinct entity or a variant of ATRT. Therefore, 10 CRINETs were clinically and molecularly characterized and compar... περισσότερα »
Probiotics, Prebiotics & Food allergy Prevention: Clinical Data in Children.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*Probiotics, Prebiotics & Food allergy Prevention: Clinical Data in Children.* J Pediatr Gastroenterol Nutr. 2016 Jul;63(1S Suppl 1):S14-S17 Authors: Fiocchi A, Pecora V, Dahdah L Abstract PURPOSE OF REVIEW: there are accruing evidences on the role of the intestinal microbiota in the development of allergic diseases among infants. Elaborating on this theoretical basis, studies did assess the possibilities to prevent allergic diseases in infancy through manipulation of the intestinal microbiota. We review here such studies. RECENT FINDINGS: interventional studies led to conflicting... περισσότερα »
Corticotropin-releasing factor (CRF) system localization in human fetal heart.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*Corticotropin-releasing factor (CRF) system localization in human fetal heart.* Hormones (Athens). 2016 Jan;15(1):55-64 Authors: Chouridou E, Lambropoulou M, Koureta M, Zarouchlioti C, Balgouranidou I, Nena E, Papadopoulos N, Chatzaki E Abstract OBJECTIVE: The corticotropin-releasing factor (CRF) family consists of the neuropeptides CRF, Ucn I, II and III and the binding sites CRFR1, CRFR2 and CRF-BP. It regulates stress response and the homeostasis of an organism. In this study, we examined the presence of the CRF system in the human hearts of normal and pathological fetuses. D... περισσότερα »
Experiences of hearing loss and views towards interventions to promote uptake of rehabilitation support among UK adults.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*Experiences of hearing loss and views towards interventions to promote uptake of rehabilitation support among UK adults.* Int J Audiol. 2016 Jul 5;:1-8 Authors: Rolfe C, Gardner B Abstract OBJECTIVE: Effective hearing loss rehabilitation support options are available. Yet, people often experience delays in receiving rehabilitation support. This study aimed to document support-seeking experiences among a sample of UK adults with hearing loss, and views towards potential strategies to increase rehabilitation support uptake. People with hearing loss were interviewed about their exp... περισσότερα »
Speech perception in medico-legal assessment of hearing disabilities.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*Speech perception in medico-legal assessment of hearing disabilities.* Int J Audiol. 2016 Jul 5;:1-9 Authors: Pedersen ER, Juhl PM, Wetke R, Ture Dammann Andersen Abstract OBJECTIVE: Examination of Danish data for medico-legal compensations regarding hearing disabilities. The study purposes are: (1) to investigate whether discrimination scores (DSs) relate to patients' subjective experience of their hearing and communication ability (the latter referring to audio-visual perception), (2) to compare DSs from different discrimination tests (auditory/audio-visual perception and witho... περισσότερα »
Electrochemotherapy for basocellular and squamocellular head and neck cancer: preliminary experience in day surgery unit.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
Electrochemotherapy for basocellular and squamocellular head and neck cancer: preliminary experience in day surgery unit.: Electrochemotherapy for basocellular and squamocellular head and neck cancer: preliminary experience in day surgery unit. G Ital Dermatol Venereol. 2016 Jul 5; Authors: Montuori M, Santurro L, Feliziani A, DE Sanctis F, Ricciardi E, Gaudio D, Campione E, Bianchi L, Silvi MB, Rossi P Abstract BACKGROUND: To evaluate feasibility, safety and efficacy in day surgery of Electrochemotherapy using Bleomycin in non melanoma Head and Neck skin cancer. METHODS: We perfo... περισσότερα »
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Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
http://ift.tt/29NKgKS: Safety, complications and patients' acceptance of Mohs micrographic surgery (MMS) under local anaesthesia - results from the UK MAPS (Mohs Acceptance and Patient Safety) Collaboration Group. Br J Dermatol. 2016 Jul 5; Authors: Hussain W, Affleck A, Al-Niaimi F, Cooper A, Craythorne E, Fleming C, Ghura V, Langtry J, Lawrence C, Loghdey S, Naysmith L, Oliphant T, Rahim R, Rice S, Sivaramkrishan M, Stables G, Varma S, Mallipeddi R Abstract By virtue of its tissue sparing properties and assessment of 100% of the margin of excised specimens, MMS is regarded as th... περισσότερα »
Fe de errores a «Metástasis laríngea de melanoma lentiginoso acral: imágenes de banda estrecha»
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
Fe de errores a «Metástasis laríngea de melanoma lentiginoso acral: imágenes de banda estrecha»: Publication date: July–August 2016Source:Acta Otorrinolaringológica Española, Volume 67, Issue 4 Author(s): Eulalia Porras Alonso, Blidy Noemith Añaguari Torres, Miguel Alberto Rodríguez Pérez from Melanoma2 via ola Kala on Inoreader via IFTTT http://ift.tt/29iuCqy
Screening for arteriovenous malformations in hereditary haemorrhagic telangiectasia.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*Screening for arteriovenous malformations in hereditary haemorrhagic telangiectasia.* J Laryngol Otol. 2016 Jul 5;:1-9 Authors: Jervis S, Skinner D Abstract OBJECTIVE: To determine whether patients with hereditary haemorrhagic telangiectasia were being screened according to international guidelines, and to review recent evidence in order to provide up-to-date guidelines for the initial systemic management of hereditary haemorrhagic telangiectasia. METHODS: A retrospective case note analysis was conducted, assessing patients in terms of screening for: genetics, cerebral arterioven... περισσότερα »
Management of airway obstruction with nebulised adrenaline resulting in takotsubo cardiomyopathy: case report.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*Management of airway obstruction with nebulised adrenaline resulting in takotsubo cardiomyopathy: case report.* J Laryngol Otol. 2016 Jul 5;:1-4 Authors: Keshtkar F, Dale OT, Bennett WO, Hall CE Abstract BACKGROUND: Takotsubo cardiomyopathy has been associated with the use of catecholamines; however, its development after the use of nebulised adrenaline for the management of acute airway obstruction has not previously been described. CASE REPORT: A 66-year-old man with squamous cell carcinoma of the larynx, with tumour-node-metastasis staging of T3N2cM0, confirmed by biopsy and ... περισσότερα »
Investigating the KNDy hypothesis in humans by co-administration of kisspeptin, neurokinin B and naltrexone in men.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*Investigating the KNDy hypothesis in humans by co-administration of kisspeptin, neurokinin B and naltrexone in men.* J Clin Endocrinol Metab. 2016 Jul 5;:jc20161911 Authors: Narayanaswamy S, Prague JK, Jayasena CN, Papadopoulou DA, Mizamtsidi M, Shah AJ, Bassett P, Comninos AN, Abbara A, Bloom SR, Veldhuis JD, Dhillo WS Abstract CONTEXT: A subpopulation of hypothalamic neurons co-localise three neuropeptides namely kisspeptin, neurokinin B (NKB) and dynorphin collectively termed KNDy neurons. Animal studies suggest they interact to affect pulsatile GnRH release (KNDy hypothesis)... περισσότερα »
Self-directed simulation-based training of emergency cricothyroidotomy: a route to lifesaving skills.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*Self-directed simulation-based training of emergency cricothyroidotomy: a route to lifesaving skills.* Eur Arch Otorhinolaryngol. 2016 Jul 5; Authors: Melchiors J, Todsen T, Nilsson P, Kohl AP, Bøttger M, Charabi B, Konge L, von Buchwald C Abstract The emergency cricothyroidotomy (EC) is a critical procedure. The high cost of failures increases the demand for evidence-based training methods. The aim of this study was to present and evaluate self-directed video-guided simulation training. Novice doctors were given an individual 1-h simulation training session. One month later, an... περισσότερα »
Jugulotympanic paragangliomas in southern Finland: a 40-year experience suggests individualized surgical management.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*Jugulotympanic paragangliomas in southern Finland: a 40-year experience suggests individualized surgical management.* Eur Arch Otorhinolaryngol. 2016 Jul 5; Authors: Nicoli TK, Sinkkonen ST, Anttila T, Mäkitie A, Jero J Abstract Treatment of jugulotympanic paragangliomas (JTPGLs) remains challenging with no clear guidelines for management or follow-up. The aim of this retrospective case-note study was to assess long-term results of operatively and conservatively managed JTPGLs between years 1974-2013. A total of 36 patients with JTPGLs were identified. Clinical characteristics a... περισσότερα »
Cetuximab as treatment for head and neck cancer patients with a previous liver transplant: report of two cases.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*Cetuximab as treatment for head and neck cancer patients with a previous liver transplant: report of two cases.* J Chemother. 2016 Jul 5;:1-4 Authors: Holguin F, Rubió-Casadevall J, Saigi M, Marruecos J, Taberna M, Tobed M, Maños M, Mesía R Abstract Cetuximab is a monoclonal antibody against epidermal growth factor receptor useful in the treatment of patients with Head and Neck Squamous Cell Carcinoma combined with radiotherapy or chemotherapy. Its pharmacokinetics are not influenced by hepatic status and there are no specific warnings concerning its indication in patients with ... περισσότερα »
Clinical features and treatment strategy for HPV-related oropharyngeal cancer.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*Clinical features and treatment strategy for HPV-related oropharyngeal cancer.* Int J Clin Oncol. 2016 Jul 5; Authors: Okami K Abstract Among head and neck squamous cell carcinoma (HNSCC), the incidence of oropharyngeal SCC (OPSCC) is increasing in contrast to carcinoma with origin in other subsites. Human papillomavirus (HPV) is now recognized as a significant risk factor of the carcinogenesis of OPSCC. The HPV-related OPSCC patients tend to be relatively young, less exposed to tobacco and alcohol, and have a relatively high socioeconomic status and education level, which is d... περισσότερα »
Definitive chemoradiation alters the immunologic landscape and immune checkpoints in head and neck cancer.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*Definitive chemoradiation alters the immunologic landscape and immune checkpoints in head and neck cancer.* Br J Cancer. 2016 Jul 5;115 Authors: Sridharan V, Margalit DN, Lynch SA, Severgnini M, Zhou J, Chau NG, Rabinowits G, Lorch JH, Hammerman PS, Hodi FS, Haddad RI, Tishler RB, Schoenfeld JD Abstract BACKGROUND: Preclinical and clinical studies suggest potential synergy between high dose per fraction focal radiation and immunotherapy. However, conventionally fractionated radiation regimens in combination with concurrent chemotherapy are more commonly administered to patients ... περισσότερα »
The cortical irregularity in the transition zone of the radial head and neck: a reliable radiographic sign of an occult radial head fracture.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*The cortical irregularity in the transition zone of the radial head and neck: a reliable radiographic sign of an occult radial head fracture.* Arch Orthop Trauma Surg. 2016 Jul 5; Authors: Leschinger T, Müller LP, Hackl M, Wegmann K Abstract PURPOSE: Exclusion or detection of non-displaced radial head fractures can be difficult in radiographs, because they might lack conclusive radiographic signs, such as fracture lines or distracted articular fragments. Based on the typical injury mechanism of a radial head fracture, causing the head to hit the capitulum and leading to a depress... περισσότερα »
RAB25 expression is epigenetically downregulated in oral and oropharyngeal squamous cell carcinoma with lymph node metastasis.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*RAB25 expression is epigenetically downregulated in oral and oropharyngeal squamous cell carcinoma with lymph node metastasis.* Epigenetics. 2016 Jul 5;:0 Authors: Clausen MJ, Melchers LJ, Mastik MF, Slagter-Menkema L, Groen HJ, van der Laan BF, van Criekinge W, de Meyer T, Denil S, van der Vegt B, Wisman GB, Roodenburg JL, Schuuring E Abstract Oral and oropharyngeal squamous cell carcinoma (OOSCC) have a low survival rate, mainly due to metastasis to the regional lymph nodes. For optimal treatment of these metastases, a neck dissection is required; however, inaccurate detection... περισσότερα »
Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 rearrangements, and common genetic alterations.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 rearrangements, and common genetic alterations.* Cancer. 2016 Jul 5; Authors: Chiosea SI, Thompson LD, Weinreb I, Bauman JE, Mahaffey AM, Miller C, Ferris RL, Gooding WE Abstract BACKGROUND: The authors hypothesized that histogenetic classification of salivary duct carcinoma (SDC) could account for de novo tumors and those with morphologic or molecular evidence (pleomorphic adenoma gene 1 [PLAG1], high-mobility group AT hook 2 [HMGA2] rearrangement, amplification) of pleomo... περισσότερα »
Current state of stem cell-mediated therapies for facial nerve injury.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*Current state of stem cell-mediated therapies for facial nerve injury.* Curr Opin Otolaryngol Head Neck Surg. 2016 Jul 1; Authors: Wang TV, Delaney S, Pepper JP Abstract PURPOSE OF REVIEW: Interest in the application of stem cell therapy to nerve injury has grown exponentially in recent years, as the armamentarium of potential stem cell sources has increased. This article reviews literature on the recent developments in the application of stem cell therapy for facial nerve injury. RECENT FINDINGS: Current stem cell therapy for the treatment of peripheral nerve injury can be gener... περισσότερα »
Primary treatment of idiopathic sudden sensorineural hearing loss with intratympanic dexamethasone.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 24 δευτερόλεπτα
*Primary treatment of idiopathic sudden sensorineural hearing loss with intratympanic dexamethasone.* Curr Opin Otolaryngol Head Neck Surg. 2016 Jul 1; Authors: Hobson CE, Alexander TH, Harris JP Abstract PURPOSE OF REVIEW: Systemic corticosteroids have been the mainstay of treatment of idiopathic sudden sensorineural hearing loss (ISSNHL) for over 30 years. Recently, intratympanic steroids have risen in popularity; however, there is no consensus regarding the details of their application. The purpose of this article is to review the current literature and share our opinion that ... περισσότερα »
Current Topics in Postnatal Behavioral Testing
The study of developmental neurotoxicity (DNT) continues to be an important component of safety evaluation of candidate therapeutic agents and of industrial and environmental chemicals. Developmental neurotoxicity is considered to be an adverse change in the central and/or peripheral nervous system during development of an organism and has been primarily evaluated by studying functional outcomes,… Continue reading Current Topics in Postnatal Behavioral Testing
Toxicological Evaluation of {beta}-Caryophyllene Oil: Subchronic Toxicity in Rats
In a subchronic toxicity study, administration of β-caryophyllene (BCP) oil by oral gavage to Wistar rats at dosages of 0, 150, 450, or 700 mg/kg/d for 90 days, including a 21-day recovery period, did not produce any significant toxicologic manifestations. The study design also included a 28-day interim sacrifice in the control and high-dose groups.… Continue reading Toxicological Evaluation of {beta}-Caryophyllene Oil: Subchronic Toxicity in Rats
Stable isotope ecology of Hippotherium from the Late Miocene Pannonian Basin system
Publication date: 1 October 2016 Source:Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 459 Author(s): Michael R. Johnson, Dana H. Geary The retreat of the Paratethys Sea in the Middle to Late Miocene left behind a series of intermontane lakes across Central Europe. Ancient Lake Pannon, which existed in present-day Hungary and surrounding countries, was gradually filled in by… Continue reading Stable isotope ecology of Hippotherium from the Late Miocene Pannonian Basin system
Apolipoprotein E gene polymorphism and the risk of subarachnoid hemorrhage: a meta-analysis of case–control studies
Abstract Background Studies investigating the association between the apolipoprotein E gene (APOE) polymorphism and the risk of subarachnoid hemorrhage (SAH) have reported inconsistent results. So we performed a meta-analysis to estimate the association between APOE polymorphism and SAH susceptibility. Methods Relevant studies published before 5 November 2015 were identified by searching PubMed, Embase, EBSCO, and… Continue reading Apolipoprotein E gene polymorphism and the risk of subarachnoid hemorrhage: a meta-analysis of case–control studies
Torres-Corzo J, Rangel-Castilla L, Nakaji P (eds) Neuroendoscopic surgery
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29nvw5R via IFTTT
Giant cavernous malformation in the ventrolateral midbrain with extension into the thalamus: a case report of a paramedian supracerebellar transtentorial approach
Abstract Cavernous malformations (CMs) of the midbrain and thalamus are relatively rare and particularly difficult to be resected given their location in eloquent tissues. Here, we report a case of a 14-year-old boy who experienced repeated and progressive right hemiparesis. Image examinations showed a gradually enlarged CM originated in the left ventrolateral midbrain extending to… Continue reading Giant cavernous malformation in the ventrolateral midbrain with extension into the thalamus: a case report of a paramedian supracerebellar transtentorial approach
Author response: The essense of primum no nocere –striking a balance between benefit and harm
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29nvxGX via IFTTT
‘Noises in the head’: a prospective study to characterize intracranial sounds after cranial surgery
Abstract Background Patients often report sounds in the head after craniotomy. We aim to characterize the prevalence and nature of these sounds, and identify any patient, pathology, or technical factors related to them. These data may be used to inform patients of this sometimes unpleasant, but harmless effect of cranial surgery. Methods Prospective observational study… Continue reading ‘Noises in the head’: a prospective study to characterize intracranial sounds after cranial surgery
Stereotactic radiosurgery planning based on time-resolved CTA for arteriovenous malformation: a case report and review of the literature
Abstract Stereotactic radiosurgery has long been recognized as the optimal form of management for high-grade arteriovenous malformations not amenable to surgical resection. Radiosurgical plans have generally relied upon the integration of stereotactic magnetic resonance angiography (MRA), standard contrast-enhanced magnetic resonance imaging (MRI), or computed tomography angiography (CTA) with biplane digital subtraction angiography (DSA). Current options… Continue reading Stereotactic radiosurgery planning based on time-resolved CTA for arteriovenous malformation: a case report and ... περισσότερα »
Postural stability in patients with chronic subdural hematoma
Abstract Background Gait disturbances and falls are common in patients with chronic subdural hematoma (cSDH). Postural stability is mainly visually assessed and has not been described using an objective and quantitative measurement tool. The objective of this prospective study was to evaluate postural stability in cSDH patients by measuring trunk sway during stance and gait… Continue reading Postural stability in patients with chronic subdural hematoma
Design of molecular imprinting biosensor with multi-scale roughness for the detection across a broad spectrum of biomolecules
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C6AN01157H, Paper Yingjie Yu, Qi Zhang, Chung-Chueh Chang, Ying Liu, Zhenhua Yang, Yichen Guo, Yantian Wang, Dennis Galanakis, Kalle Levon, Miriam H Rafailovich Molecular imprinting technique has tremendous applications in artificial enzymes, bioseparation, and sensor devices. In this study, a novel molecular imprinting (MI) biosensor platform was developed for the detection of a... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/29p... περισσότερα »
Experiences of hearing loss and views towards interventions to promote uptake of rehabilitation support among UK adults
10.1080/14992027.2016.1200146<br>Crystal Rolfe from #Audiology via xlomafota13 on Inoreader http://ift.tt/29qhFfw via IFTTT
Speech perception in medico-legal assessment of hearing disabilities
10.1080/14992027.2016.1198967<br>Ellen Raben Pedersen from #Audiology via xlomafota13 on Inoreader http://ift.tt/29x1jEP via IFTTT
Experiences of hearing loss and views towards interventions to promote uptake of rehabilitation support among UK adults.
*Experiences of hearing loss and views towards interventions to promote uptake of rehabilitation support among UK adults.* Int J Audiol. 2016 Jul 5;:1-8 Authors: Rolfe C, Gardner B Abstract OBJECTIVE: Effective hearing loss rehabilitation support options are available. Yet, people often experience delays in receiving rehabilitation support. This study aimed to document support-seeking experiences among a sample of UK adults with hearing loss, and views towards potential strategies to increase rehabilitation support uptake. People with hearing loss were interviewed about their exp... περισσότερα »
CD80 down-regulation is associated to aberrant DNA methylation in non-inflammatory colon carcinogenesis.
*CD80 down-regulation is associated to aberrant DNA methylation in non-inflammatory colon carcinogenesis.* BMC Cancer. 2016;16(1):388 Authors: Scarpa M, Scarpa M, Castagliuolo I, Erroi F, Basato S, Brun P, Angriman I, Castoro C Abstract BACKGROUND: The lack of positive costimulatory molecules represents one of the mechanisms by which tumor cells evade immune surveillance. Promoter hypermethylation plays a major role in cancer development through transcriptional silencing of critical genes. The aim of this study was to examine the expression of the costimulatory molecule CD80 in r... περισσότερα »
Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.
*Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.* Chem Senses. 2016 Jul 4; Authors: Untiet V, Moeller LM, Ibarra-Soria X, Sánchez-Andrade G, Stricker M, Neuhaus EM, Logan DW, Gensch T, Spehr M Abstract In rodents, the vomeronasal system controls social and sexual behavior. However, several mechanistic aspects of sensory signaling in the vomeronasal organ remain unclear. Here, we investigate the biophysical basis of a recently proposed vomeronasal signal transduction component-a Ca(2+)-activated Cl(-) current. As the physiological rol... περισσότερα »
Effects of age and non-oropharyngeal proprioceptive and exteroceptive sensation on the magnitude of anticipatory mouth opening during eating.
*Effects of age and non-oropharyngeal proprioceptive and exteroceptive sensation on the magnitude of anticipatory mouth opening during eating.* J Oral Rehabil. 2016 Jul 5; Authors: Shune SE, Moon JB Abstract To best prevent and treat eating/swallowing problems, it is essential to understand how components of oral physiology contribute to the preservation and/or degradation of eating/swallowing in healthy ageing. Anticipatory, pre-swallow motor movements may be critical to safe and efficient eating/swallowing, particularly for older adults. However, the nature of these responses i... περισσότερα »
A randomised controlled trial of Caphosol mouthwash in management of radiation-induced mucositis in head and neck cancer
[image: S01678140.gif] Publication date: Available online 5 July 2016 *Source:*Radiotherapy and Oncology Author(s): Kee H. Wong, Aleksandra Kuciejewska, Mansour T.A. Sharabiani, Brian Ng-Cheng-Hin, Sonja Hoy, Tara Hurley, Joanna Rydon, Lorna Grove, Ana Santos, Motoko Ryugenji, Shreerang A. Bhide, Chris M. Nutting, Kevin J. Harrington, Kate L. Newbold PurposeThis phase III, non-blinded, parallel-group, randomised controlled study evaluated the efficacy of Caphosol mouthwash in the management of radiation-induced oral mucositis (OM) in patients with head and neck cancer (HNC) undergoi... περισσότερα »
Effects of anatomical changes on pencil beam scanning proton plans in locally advanced NSCLC patients
[image: S01678140.gif] Publication date: Available online 5 July 2016 *Source:*Radiotherapy and Oncology Author(s): Yenny Z. Szeto, Marnix G. Witte, Simon R. van Kranen, Jan-Jakob Sonke, José Belderbos, Marcel van Herk Background and purposeDaily anatomical variations can cause considerable differences between delivered and planned dose. This study simulates and evaluates these effects in spot-scanning proton therapy for lung cancer patients.Materials and methodsRobust intensity modulated treatment plans were designed on the mid-position CT scan for sixteen locally advanced lung can... περισσότερα »
Individualized multimodal treatment strategy for anaplastic thyroid carcinoma-Case report of long-term remission and review of literature.
*Individualized multimodal treatment strategy for anaplastic thyroid carcinoma-Case report of long-term remission and review of literature.* Int J Surg Case Rep. 2016 Jun 16;25:174-178 Authors: Eckhardt S, Hoffmann S, Damanakis AI, Di Fazio P, Pfestroff A, Luster M, Wunderlich A, Bartsch DK Abstract INTRODUCTION: The prognosis of anaplastic thyroid cancer (ATC) is poor with a mean survival time of six months following diagnosis. Despite various attempts to modify common treatment modalities including surgery, external beam radiation and chemotherapy, an effective treatment is not ... περισσότερα »
[Grading of neuroendocrine tumors].
*[Grading of neuroendocrine tumors].* Pathologe. 2016 Jul 5; Authors: Saeger W, Schnabel PA, Komminoth P Abstract The current WHO classification of neuroendocrine tumors (NET) differentiates between typical carcinoids (low grade NET), atypical carcinoids (intermediate grade NET) and small cell and large cell carcinomas (high grade NET) according to the prognosis. Neuroendocrine neoplasms (NEN) of the gastrointestinal tract and the pancreas are graded in an identical way. Together with the TNM system this enables a preoperative estimation of the prognosis in biopsies and fine need... περισσότερα »
Gonadal agenesis with hypoplastic paramesonephric ducts (PMNDs) derivatives in dizygotic twins.
*Gonadal agenesis with hypoplastic paramesonephric ducts (PMNDs) derivatives in dizygotic twins.* Gynecol Endocrinol. 2016 Jul 5;:1-4 Authors: Miolo G, Del Pup L, Ash A, Manno M, Pivetta B, Tessitori G, Corona G Abstract The co-occurrence of gonadal agenesis alongside hypoplastic derivatives of the paramesonephric ducts has rarely been observed. PATIENT(S): 16-year-old dizygotic twin sisters were referred to our department because of primary amenorrhea. X-ray, bone densitometry, ultrasonography, pelvic MRI and measurement of pituitary, ovary, and thyroid hormones were performed. ... περισσότερα »
Presence of histological regression as a prognostic factor in cutaneous melanoma patients.
*Presence of histological regression as a prognostic factor in cutaneous melanoma patients.* Melanoma Res. 2016 Jul 1; Authors: Tas F, Erturk K Abstract Regression is caused by a host immunological response primarily characterized by lymphocytic infiltration directed against melanoma cells. The prognostic significance of regression remains controversial in cutaneous melanoma patients. The aim of this study was to determine the clinical significance of the histological regression status in patients with cutaneous melanoma. A total of 664 patients with a pathologically confirmed c... περισσότερα »
What is optimal first-line treatment of unresectable or advanced BRAF-mutant melanoma?
*What is optimal first-line treatment of unresectable or advanced BRAF-mutant melanoma?* Clin Adv Hematol Oncol. 2016 Jun;14(6):417-419 Authors: Atkins MB PMID: 27379810 [PubMed - as supplied by publisher] from Melanoma via xlomafota13 on Inoreader http://ift.tt/29NKtOb
(13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism.
*(13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism.* Front Oncol. 2016;6:135 Authors: Shestov AA, Lee SC, Nath K, Guo L, Nelson DS, Roman JC, Leeper DB, Wasik MA, Blair IA, Glickson JD Abstract We present the first validated metabolic network model for analysis of flux through key pathways of tumor intermediary metabolism, including glycolysis, the oxidative and non-oxidative arms of the pentose pyrophosphate shunt, the TCA cycle as well as its anaplerotic pathways, pyruvate-malate shuttling, glutaminolysis, and fatty acid biosynthesis and oxidation. The model th... περισσότερα »
Protease-Activated Receptors and other G-Protein-Coupled Receptors: the Melanoma Connection.
*Protease-Activated Receptors and other G-Protein-Coupled Receptors: the Melanoma Connection.* Front Genet. 2016;7:112 Authors: Rosero RA, Villares GJ, Bar-Eli M Abstract The vast array of G-protein-coupled receptors (GPCRs) play crucial roles in both physiological and pathological processes, including vision, coagulation, inflammation, autophagy, and cell proliferation. GPCRs also affect processes that augment cell proliferation and metastases in many cancers including melanoma. Melanoma is the deadliest form of skin cancer, yet limited therapeutic modalities are available to pa... περισσότερα »
Impact of patient age on the iodine/FDG "flip-flop" phenomenon in lung metastasis from thyroid cancer.
*Impact of patient age on the iodine/FDG "flip-flop" phenomenon in lung metastasis from thyroid cancer.* Ann Nucl Med. 2016 Jul 5; Authors: Isoda T, BaBa S, Maruoka Y, Kitamura Y, Tahara K, Sasaki M, Honda H Abstract OBJECTIVES: Radioiodine therapy is an effective treatment for lung metastasis from thyroid cancer. However, cases of lung metastasis without iodine uptake are often encountered. In such cases, FDG accumulation in lung lesions is often observed. There is a reverse relationship between iodine and FDG accumulation in thyroid cancer lesions, the so-called "flip-flop" phe... περισσότερα »
Single-molecule force-spectroscopy reveals the calcium dependency of the alternative conformations in the native state of a βγ-crystallin protein.
*Single-molecule force-spectroscopy reveals the calcium dependency of the alternative conformations in the native state of a βγ-crystallin protein.* J Biol Chem. 2016 Jul 4; Authors: Scholl ZN, Li Q, Yang W, Marszalek PE Abstract Though multidomain proteins predominate the proteome of all organisms, and are expected to display complex folding behaviors and significantly greater structural dynamics as compared to single-domain proteins, their conformational heterogeneity and its impact on their interaction with ligands is poorly understood due to lack of experimental techniques. Th... περισσότερα »
Plasma vemurafenib exposure and pre-treatment hepatocyte growth factor level are two factors contributing to the early peripheral lymphocytes depletion in BRAF-mutated melanoma patients.
*Plasma vemurafenib exposure and pre-treatment hepatocyte growth factor level are two factors contributing to the early peripheral lymphocytes depletion in BRAF-mutated melanoma patients.* Pharmacol Res. 2016 Jul 1; Authors: Alicja P, Mélanie WK, Nicolas D, Nora K, Audrey TS, Gaëlle N, Nicolas C, Michel V, François G, Etienne C, Benoit B Abstract The therapeutic response to vemurafenib, a BRAF serine-threonine kinase inhibitor, exhibits large variations between patients. Evaluation of factors predicting the clinical efficacy of vemurafenib may help to identify patients at high ri... περισσότερα »
Head and neck cancer surgery provision in England: A current analysis of contributing specialties caseloads.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 59 δευτερόλεπτα
*Head and neck cancer surgery provision in England: A current analysis of contributing specialties caseloads.* Br J Oral Maxillofac Surg. 2016 Jul 1; Authors: Islam S, Wates E, Hayter JP Abstract To ascertain the current provision for surgery for head and neck cancer in England with respect to the operative caseloads of oral and maxillofacial, ear nose and throat (ENT) and plastic surgeons, we analysed data from the 2013 report of the National Head and Neck Audit (DAHNO). Clinicians were grouped by specialty of affiliation and assigned surgical caseloads were compared. There was ... περισσότερα »
Effects of Swimming Goggles Wearing on Intraocular Pressure, Ocular Perfusion Pressure, and Ocular Pulse Amplitude.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 59 δευτερόλεπτα
*Effects of Swimming Goggles Wearing on Intraocular Pressure, Ocular Perfusion Pressure, and Ocular Pulse Amplitude.* J Glaucoma. 2016 Jul 2; Authors: Paula AP, Paula JS, Silva MJ, Rocha EM, De Moraes CG, Rodrigues ML Abstract PURPOSE: To evaluate changes in the ocular pulse amplitude (OPA) and ocular perfusion pressure (OPP), and investigate factors associated with intraocular pressure (IOP) elevation due to periorbital compression during swimming goggles (SG) use. METHODS: This cross-sectional study evaluated 35 eyes of 35 healthy volunteers during the wearing of a drilled SG. O... περισσότερα »
Cetuximab-induced aseptic meningitis: case report and review of a rare adverse event.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 59 δευτερόλεπτα
*Cetuximab-induced aseptic meningitis: case report and review of a rare adverse event.* BMC Cancer. 2016;16(1):384 Authors: Maritaz C, Metz C, Baba-Hamed N, Jardin-Szucs M, Deplanque G Abstract BACKGROUND: Cetuximab is a commonly used antibody agent in the treatment of colorectal or head and neck cancer. Although it is generally well tolerated in most patients, cetuximab has been associated with some rare but serious adverse events. Aseptic meningitis is one such distinctly uncommon adverse drug reaction. CASE PRESENTATION: We present the case of a middle-aged Caucasian patient, ... περισσότερα »
A prognostic model for resectable soft tissue and cutaneous angiosarcoma.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 59 δευτερόλεπτα
*A prognostic model for resectable soft tissue and cutaneous angiosarcoma.* J Surg Oncol. 2016 Jul 4; Authors: Sinnamon AJ, Neuwirth MG, McMillan MT, Ecker BL, Bartlett EK, Zhang PJ, Kelz RR, Fraker DL, Roses RE, Karakousis GC Abstract BACKGROUND: Angiosarcoma is an aggressive tumor rising in incidence from use of therapeutic radiation. Because of its relative rarity, prognostic factors have not been clearly delineated. METHODS: Patients who underwent resection of localized angiosarcoma from 2002 to 2012 were identified using the National Cancer Data Base. Factors associated with ... περισσότερα »
Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.* Chem Senses. 2016 Jul 4; Authors: Untiet V, Moeller LM, Ibarra-Soria X, Sánchez-Andrade G, Stricker M, Neuhaus EM, Logan DW, Gensch T, Spehr M Abstract In rodents, the vomeronasal system controls social and sexual behavior. However, several mechanistic aspects of sensory signaling in the vomeronasal organ remain unclear. Here, we investigate the biophysical basis of a recently proposed vomeronasal signal transduction component-a Ca(2+)-activated Cl(-) current. As the physiological rol... περισσότερα »
Intraperitoneal mesenchymal stem cell administration ameliorates allergic rhinitis in the murine model.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*Intraperitoneal mesenchymal stem cell administration ameliorates allergic rhinitis in the murine model.* Eur Arch Otorhinolaryngol. 2016 Jul 5; Authors: Işık S, Karaman M, Adan A, Kıray M, Bağrıyanık HA, Sözmen ŞÇ, Kozanoğlu İ, Karaman Ö, Baran Y, Uzuner N Abstract Previous studies showed that bone marrow-derived mesenchymal stem cells (BMSCs) could ameliorate a variety of immune-mediated and inflammatory diseases due to their immunomodulatory and anti-inflammatory effects. In this study, we developed a mouse model of ovalbumin (OVA) induced allergic inflammation in the upper ai... περισσότερα »
Comparison of full-night and ambulatory polysomnography with ApneaGraph in the subjects with obstructive sleep apnea syndrome.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*Comparison of full-night and ambulatory polysomnography with ApneaGraph in the subjects with obstructive sleep apnea syndrome.* Eur Arch Otorhinolaryngol. 2016 Jul 4; Authors: Karaloğlu F, Kemaloğlu YK, Yilmaz M, Ulukavak Çiftçi T, Çiftçi B, Bakkal FK Abstract The localization of the obstruction is crucial in determining the appropriate surgical treatment for obstructive sleep apnea syndrome (OSAS); ApneaGraph has been introduced for diagnosis of OSAS and localization of airway obstruction level. This study aims to evaluate the diagnostic value of ApneaGraph for both clinical st... περισσότερα »
Inflammatory reaction to hyaluronic acid: A newly described complication in vocal fold augmentation.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*Inflammatory reaction to hyaluronic acid: A newly described complication in vocal fold augmentation.* Laryngoscope. 2016 Jul 5; Authors: Dominguez LM, Tibbetts KM, Simpson CB Abstract OBJECTIVES/HYPOTHESIS: To establish the rate of inflammatory reaction to hyaluronic acid (HA) in vocal fold injection augmentation, determine the most common presenting signs and symptoms, and propose an etiology. STUDY DESIGN: Retrospective chart review. METHODS: Patients injected with HA over a 5-year period were reviewed to identify those who had a postoperative inflammatory reaction. Medical rec... περισσότερα »
Screening for arteriovenous malformations in hereditary haemorrhagic telangiectasia.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*Screening for arteriovenous malformations in hereditary haemorrhagic telangiectasia.* J Laryngol Otol. 2016 Jul 5;:1-9 Authors: Jervis S, Skinner D Abstract OBJECTIVE: To determine whether patients with hereditary haemorrhagic telangiectasia were being screened according to international guidelines, and to review recent evidence in order to provide up-to-date guidelines for the initial systemic management of hereditary haemorrhagic telangiectasia. METHODS: A retrospective case note analysis was conducted, assessing patients in terms of screening for: genetics, cerebral arterioven... περισσότερα »
Management of airway obstruction with nebulised adrenaline resulting in takotsubo cardiomyopathy: case report.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*Management of airway obstruction with nebulised adrenaline resulting in takotsubo cardiomyopathy: case report.* J Laryngol Otol. 2016 Jul 5;:1-4 Authors: Keshtkar F, Dale OT, Bennett WO, Hall CE Abstract BACKGROUND: Takotsubo cardiomyopathy has been associated with the use of catecholamines; however, its development after the use of nebulised adrenaline for the management of acute airway obstruction has not previously been described. CASE REPORT: A 66-year-old man with squamous cell carcinoma of the larynx, with tumour-node-metastasis staging of T3N2cM0, confirmed by biopsy and ... περισσότερα »
Use of Language Sample Analysis by School-Based SLPs: Results of a Nationwide Survey.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*Use of Language Sample Analysis by School-Based SLPs: Results of a Nationwide Survey.* Lang Speech Hear Serv Sch. 2016 Jul 4;:1-13 Authors: Pavelko SL, Owens RE, Ireland M, Hahs-Vaughn DL Abstract Purpose: This article examines use of language sample analysis (LSA) by school-based speech-language pathologists (SLPs), including characteristics of language samples, methods of transcription and analysis, barriers to LSA use, and factors affecting LSA use, such as American Speech-Language-Hearing Association certification, number of years’ experience, and caseload characteristics. M... περισσότερα »
Family and Community Predictors of Comorbid Language, Socioemotional and Behavior Problems at School Entry.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*Family and Community Predictors of Comorbid Language, Socioemotional and Behavior Problems at School Entry.* PLoS One. 2016;11(7):e0158802 Authors: Hughes N, Sciberras E, Goldfeld S Abstract OBJECTIVES: To identify the prevalence and family and community-level predictors of comorbid speech-language difficulties and socioemotional and behavioral (SEB) difficulties across a population of children at school entry. METHODS: The School Entry Health Questionnaire is a parent survey of children’s health and wellbeing, completed by all children starting school in Victoria, Australia (N ... περισσότερα »
Effects of Semantic Context and Fundamental Frequency Contours on Mandarin Speech Recognition by Second Language Learners.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*Effects of Semantic Context and Fundamental Frequency Contours on Mandarin Speech Recognition by Second Language Learners.* Front Psychol. 2016;7:908 Authors: Zhang L, Li Y, Wu H, Li X, Shu H, Zhang Y, Li P Abstract Speech recognition by second language (L2) learners in optimal and suboptimal conditions has been examined extensively with English as the target language in most previous studies. This study extended existing experimental protocols (Wang et al., 2013) to investigate Mandarin speech recognition by Japanese learners of Mandarin at two different levels (elementary vs. ... περισσότερα »
Editorial: Overlap of Neural Systems for Processing Language and Music.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*Editorial: Overlap of Neural Systems for Processing Language and Music.* Front Psychol. 2016;7:876 Authors: Jantzen MG, Large EW, Magne C PMID: 27378976 [PubMed - as supplied by publisher] http://ift.tt/29wVFCD
Using the Visual World Paradigm to Study Retrieval Interference in Spoken Language Comprehension.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*Using the Visual World Paradigm to Study Retrieval Interference in Spoken Language Comprehension.* Front Psychol. 2016;7:873 Authors: Sekerina IA, Campanelli L, Van Dyke JA Abstract The cue-based retrieval theory (Lewis et al., 2006) predicts that interference from similar distractors should create difficulty for argument integration, however this hypothesis has only been examined in the written modality. The current study uses the Visual World Paradigm (VWP) to assess its feasibility to study retrieval interference arising from distractors present in a visual display during spo... περισσότερα »
An Exploration of Rhythmic Grouping of Speech Sequences by French- and German-Learning Infants.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*An Exploration of Rhythmic Grouping of Speech Sequences by French- and German-Learning Infants.* Front Hum Neurosci. 2016;10:292 Authors: Abboub N, Boll-Avetisyan N, Bhatara A, Höhle B, Nazzi T Abstract Rhythm in music and speech can be characterized by a constellation of several acoustic cues. Individually, these cues have different effects on rhythmic perception: sequences of sounds alternating in duration are perceived as short-long pairs (weak-strong/iambic pattern), whereas sequences of sounds alternating in intensity or pitch are perceived as loud-soft, or high-low pairs (... περισσότερα »
What Pinnipeds Have to Say about Human Speech, Music, and the Evolution of Rhythm.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*What Pinnipeds Have to Say about Human Speech, Music, and the Evolution of Rhythm.* Front Neurosci. 2016;10:274 Authors: Ravignani A, Fitch WT, Hanke FD, Heinrich T, Hurgitsch B, Kotz SA, Scharff C, Stoeger AS, de Boer B Abstract Research on the evolution of human speech and music benefits from hypotheses and data generated in a number of disciplines. The purpose of this article is to illustrate the high relevance of pinniped research for the study of speech, musical rhythm, and their origins, bridging and complementing current research on primates and birds. We briefly discuss ... περισσότερα »
Temporally Regular Musical Primes Facilitate Subsequent Syntax Processing in Children with Specific Language Impairment.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*Temporally Regular Musical Primes Facilitate Subsequent Syntax Processing in Children with Specific Language Impairment.* Front Neurosci. 2016;10:245 Authors: Bedoin N, Brisseau L, Molinier P, Roch D, Tillmann B Abstract Children with developmental language disorders have been shown to be also impaired in rhythm and meter perception. Temporal processing and its link to language processing can be understood within the dynamic attending theory. An external stimulus can stimulate internal oscillators, which orient attention over time and drive speech signal segmentation to provide ... περισσότερα »
Behavioural and neurophysiological disruption of corticobulbar motor systems and their effects on sequential pharyngeal swallowing.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*Behavioural and neurophysiological disruption of corticobulbar motor systems and their effects on sequential pharyngeal swallowing.* Physiol Behav. 2016 Jul 1; Authors: Al-Toubi A, Daniels SK, Huckabee ML, Corey DM, Doeltgen SH Abstract Primary motor networks are known to be involved in the control of voluntary oral movements as well as the modulation of pharyngeal movements during experimentally controlled single swallows performed on command. The role of these networks in the more typical task of sequential swallowing remains unexplored. This study evaluated the hypothesis that... περισσότερα »
Intensity of language treatment: contribution to children's language outcomes.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*Intensity of language treatment: contribution to children’s language outcomes.* Int J Lang Commun Disord. 2016 Jul 5; Authors: Schmitt MB, Justice LM, Logan JA Abstract BACKGROUND: Treatment intensity is an important factor in designing and delivering treatments to children with language impairment (LI). However, to date very little is understood about cumulative intervention intensity for children with LI in the US public school system. AIMS: To examine treatment intensity (dose: time spent on language; frequency: number of sessions; duration: one academic year) as delivered to ... περισσότερα »
The use of intracranial recordings to decode human language: Challenges and opportunities.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*The use of intracranial recordings to decode human language: Challenges and opportunities.* Brain Lang. 2016 Jul 1; Authors: Martin S, Millán JD, Knight RT, Pasley BN Abstract Decoding speech from intracranial recordings serves two main purposes: understanding the neural correlates of speech processing and decoding speech features for targeting speech neuroprosthetic devices. Intracranial recordings have high spatial and temporal resolution, and thus offer a unique opportunity to investigate and decode the electrophysiological dynamics underlying speech processing. In this revie... περισσότερα »
Cribriform neuroepithelial tumor (crinet): Molecular characterization of a smarcb1-deficient non-rhabdoid tumor with favorable long-term outcome
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
Abstract Rhabdoid phenotype and loss of SMARCB1 expression in a brain tumor are characteristic features of atypical teratoid/rhabdoid tumors (ATRT). Rare non-rhabdoid brain tumors showing cribriform growth pattern and SMARCB1 loss have been designated cribriform neuroepithelial tumor (CRINET). Small case series suggest that CRINETs may have a relatively favorable prognosis. However, the long-term outcome is unclear and it remains uncertain whether CRINET represents a distinct entity or a variant of ATRT. Therefore, 10 CRINETs were clinically and molecularly characterized and compar... περισσότερα »
Jugulotympanic paragangliomas in southern Finland: a 40-year experience suggests individualized surgical management.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*Jugulotympanic paragangliomas in southern Finland: a 40-year experience suggests individualized surgical management.* Eur Arch Otorhinolaryngol. 2016 Jul 5; Authors: Nicoli TK, Sinkkonen ST, Anttila T, Mäkitie A, Jero J Abstract Treatment of jugulotympanic paragangliomas (JTPGLs) remains challenging with no clear guidelines for management or follow-up. The aim of this retrospective case-note study was to assess long-term results of operatively and conservatively managed JTPGLs between years 1974-2013. A total of 36 patients with JTPGLs were identified. Clinical characteristics a... περισσότερα »
Self-directed simulation-based training of emergency cricothyroidotomy: a route to lifesaving skills.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 59 δευτερόλεπτα
*Self-directed simulation-based training of emergency cricothyroidotomy: a route to lifesaving skills.* Eur Arch Otorhinolaryngol. 2016 Jul 5; Authors: Melchiors J, Todsen T, Nilsson P, Kohl AP, Bøttger M, Charabi B, Konge L, von Buchwald C Abstract The emergency cricothyroidotomy (EC) is a critical procedure. The high cost of failures increases the demand for evidence-based training methods. The aim of this study was to present and evaluate self-directed video-guided simulation training. Novice doctors were given an individual 1-h simulation training session. One month later, an... περισσότερα »
Use of Language Sample Analysis by School-Based SLPs: Results of a Nationwide Survey.
*Use of Language Sample Analysis by School-Based SLPs: Results of a Nationwide Survey.* Lang Speech Hear Serv Sch. 2016 Jul 4;:1-13 Authors: Pavelko SL, Owens RE, Ireland M, Hahs-Vaughn DL Abstract Purpose: This article examines use of language sample analysis (LSA) by school-based speech-language pathologists (SLPs), including characteristics of language samples, methods of transcription and analysis, barriers to LSA use, and factors affecting LSA use, such as American Speech-Language-Hearing Association certification, number of years' experience, and caseload characteristics. M... περισσότερα »
Family and Community Predictors of Comorbid Language, Socioemotional and Behavior Problems at School Entry.
*Family and Community Predictors of Comorbid Language, Socioemotional and Behavior Problems at School Entry.* PLoS One. 2016;11(7):e0158802 Authors: Hughes N, Sciberras E, Goldfeld S Abstract OBJECTIVES: To identify the prevalence and family and community-level predictors of comorbid speech-language difficulties and socioemotional and behavioral (SEB) difficulties across a population of children at school entry. METHODS: The School Entry Health Questionnaire is a parent survey of children's health and wellbeing, completed by all children starting school in Victoria, Australia (N ... περισσότερα »
Effects of Semantic Context and Fundamental Frequency Contours on Mandarin Speech Recognition by Second Language Learners.
*Effects of Semantic Context and Fundamental Frequency Contours on Mandarin Speech Recognition by Second Language Learners.* Front Psychol. 2016;7:908 Authors: Zhang L, Li Y, Wu H, Li X, Shu H, Zhang Y, Li P Abstract Speech recognition by second language (L2) learners in optimal and suboptimal conditions has been examined extensively with English as the target language in most previous studies. This study extended existing experimental protocols (Wang et al., 2013) to investigate Mandarin speech recognition by Japanese learners of Mandarin at two different levels (elementary vs. ... περισσότερα »
Editorial: Overlap of Neural Systems for Processing Language and Music.
*Editorial: Overlap of Neural Systems for Processing Language and Music.* Front Psychol. 2016;7:876 Authors: Jantzen MG, Large EW, Magne C PMID: 27378976 [PubMed - as supplied by publisher] from Speech via xlomafota13 on Inoreader http://ift.tt/29wVFCD
Using the Visual World Paradigm to Study Retrieval Interference in Spoken Language Comprehension.
*Using the Visual World Paradigm to Study Retrieval Interference in Spoken Language Comprehension.* Front Psychol. 2016;7:873 Authors: Sekerina IA, Campanelli L, Van Dyke JA Abstract The cue-based retrieval theory (Lewis et al., 2006) predicts that interference from similar distractors should create difficulty for argument integration, however this hypothesis has only been examined in the written modality. The current study uses the Visual World Paradigm (VWP) to assess its feasibility to study retrieval interference arising from distractors present in a visual display during spo... περισσότερα »
An Exploration of Rhythmic Grouping of Speech Sequences by French- and German-Learning Infants.
*An Exploration of Rhythmic Grouping of Speech Sequences by French- and German-Learning Infants.* Front Hum Neurosci. 2016;10:292 Authors: Abboub N, Boll-Avetisyan N, Bhatara A, Höhle B, Nazzi T Abstract Rhythm in music and speech can be characterized by a constellation of several acoustic cues. Individually, these cues have different effects on rhythmic perception: sequences of sounds alternating in duration are perceived as short-long pairs (weak-strong/iambic pattern), whereas sequences of sounds alternating in intensity or pitch are perceived as loud-soft, or high-low pairs (... περισσότερα »
What Pinnipeds Have to Say about Human Speech, Music, and the Evolution of Rhythm.
*What Pinnipeds Have to Say about Human Speech, Music, and the Evolution of Rhythm.* Front Neurosci. 2016;10:274 Authors: Ravignani A, Fitch WT, Hanke FD, Heinrich T, Hurgitsch B, Kotz SA, Scharff C, Stoeger AS, de Boer B Abstract Research on the evolution of human speech and music benefits from hypotheses and data generated in a number of disciplines. The purpose of this article is to illustrate the high relevance of pinniped research for the study of speech, musical rhythm, and their origins, bridging and complementing current research on primates and birds. We briefly discuss ... περισσότερα »
Temporally Regular Musical Primes Facilitate Subsequent Syntax Processing in Children with Specific Language Impairment.
*Temporally Regular Musical Primes Facilitate Subsequent Syntax Processing in Children with Specific Language Impairment.* Front Neurosci. 2016;10:245 Authors: Bedoin N, Brisseau L, Molinier P, Roch D, Tillmann B Abstract Children with developmental language disorders have been shown to be also impaired in rhythm and meter perception. Temporal processing and its link to language processing can be understood within the dynamic attending theory. An external stimulus can stimulate internal oscillators, which orient attention over time and drive speech signal segmentation to provide ... περισσότερα »
Behavioural and neurophysiological disruption of corticobulbar motor systems and their effects on sequential pharyngeal swallowing.
*Behavioural and neurophysiological disruption of corticobulbar motor systems and their effects on sequential pharyngeal swallowing.* Physiol Behav. 2016 Jul 1; Authors: Al-Toubi A, Daniels SK, Huckabee ML, Corey DM, Doeltgen SH Abstract Primary motor networks are known to be involved in the control of voluntary oral movements as well as the modulation of pharyngeal movements during experimentally controlled single swallows performed on command. The role of these networks in the more typical task of sequential swallowing remains unexplored. This study evaluated the hypothesis that... περισσότερα »
Intensity of language treatment: contribution to children's language outcomes.
*Intensity of language treatment: contribution to children's language outcomes.* Int J Lang Commun Disord. 2016 Jul 5; Authors: Schmitt MB, Justice LM, Logan JA Abstract BACKGROUND: Treatment intensity is an important factor in designing and delivering treatments to children with language impairment (LI). However, to date very little is understood about cumulative intervention intensity for children with LI in the US public school system. AIMS: To examine treatment intensity (dose: time spent on language; frequency: number of sessions; duration: one academic year) as delivered to ... περισσότερα »
The use of intracranial recordings to decode human language: Challenges and opportunities.
*The use of intracranial recordings to decode human language: Challenges and opportunities.* Brain Lang. 2016 Jul 1; Authors: Martin S, Millán JD, Knight RT, Pasley BN Abstract Decoding speech from intracranial recordings serves two main purposes: understanding the neural correlates of speech processing and decoding speech features for targeting speech neuroprosthetic devices. Intracranial recordings have high spatial and temporal resolution, and thus offer a unique opportunity to investigate and decode the electrophysiological dynamics underlying speech processing. In this revie... περισσότερα »
Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.
*Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.* Chem Senses. 2016 Jul 4; Authors: Untiet V, Moeller LM, Ibarra-Soria X, Sánchez-Andrade G, Stricker M, Neuhaus EM, Logan DW, Gensch T, Spehr M Abstract In rodents, the vomeronasal system controls social and sexual behavior. However, several mechanistic aspects of sensory signaling in the vomeronasal organ remain unclear. Here, we investigate the biophysical basis of a recently proposed vomeronasal signal transduction component-a Ca(2+)-activated Cl(-) current. As the physiological rol... περισσότερα »
Gegenseitige Beeinflussung von Eltern und Babys in ihrem Schlafverhalten
Zusammenfassung Hintergrund Im ersten Lebensjahr eines Kindes finden weitreichende Veränderungen des Schlafrhythmus statt. Dieser Entwicklungsprozess unterliegt biologischen Vorgängen, ist jedoch in hohem Maße abhängig von Umgebungsfaktoren und elterlichen Einflüssen. Fragestellung In diesem Review wird eine Verknüpfung zwischen kindlichem Schlaf und elterlichen Kognitionen, interaktivem Verhalten, Psychopathologien und Umgebungseinflüssen hergestellt. Material und Methoden Es erfolgt eine Literaturanalyse… Continue reading Gegenseitige Beeinflussung von Eltern und Babys in ihrem Sc... περισσότερα »
Different hollow and spherical TiO2 morphologies have distinct activities for the photocatalytic inactivation of chemical and biological agents
Photochem. Photobiol. Sci., 2016, Advance Article DOI: 10.1039/C6PP00093B, Paper Yuichi Yamaguchi, Takahito Shimodo, Sho Usuki, Kanjiro Torigoe, Chiaki Terashima, Ken-ichi Katsumata, Masahiko Ikekita, Akira Fujishima, Hideki Sakai, Kazuya Nakata TiO2 hollows and spheres are a suitable morphology for photocatalytic decomposition of dimethyl sulfoxide and anti-pathogen performance, respectively. To cite this article before page numbers are… Continue reading Different hollow and spherical TiO2 morphologies have distinct activities for the photocatalytic inactivation of chemical and bio... περισσότερα »
Longitudinal changes in the dietary inflammatory index: an assessment of the inflammatory potential of diet over time in postmenopausal women
Longitudinal changes in the dietary inflammatory index: an assessment of the inflammatory potential of diet over time in postmenopausal women European Journal of Clinical Nutrition advance online publication, July 6 2016. doi:10.1038/ejcn.2016.116 Authors: F K Tabung, S E Steck, J Zhang, Y Ma, A D Liese, F A Tylavsky, M Z Vitolins, J K Ockene… Continue reading Longitudinal changes in the dietary inflammatory index: an assessment of the inflammatory potential of diet over time in postmenopausal women
Different displacement of bioimpedance vector due to Ag/AgCl electrode effect
Different displacement of bioimpedance vector due to Ag/AgCl electrode effect European Journal of Clinical Nutrition advance online publication, July 6 2016. doi:10.1038/ejcn.2016.121 Authors: L Nescolarde, H Lukaski, A De Lorenzo, B de-Mateo-Silleras, M P Redondo-del-Río & M A Camina-Martín from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29miHtE via IFTTT
Consumption of soy foods and isoflavones and risk of type 2 diabetes: a pooled analysis of three US cohorts
Consumption of soy foods and isoflavones and risk of type 2 diabetes: a pooled analysis of three US cohorts European Journal of Clinical Nutrition advance online publication, July 6 2016. doi:10.1038/ejcn.2016.117 Authors: M Ding, A Pan, J E Manson, W C Willett, V Malik, B Rosner, E Giovannucci, F B Hu & Q Sun from… Continue reading Consumption of soy foods and isoflavones and risk of type 2 diabetes: a pooled analysis of three US cohorts
Comparison of resting and total energy expenditure in peritoneal dialysis patients and body composition measured by dual-energy X-ray absorptiometry
Comparison of resting and total energy expenditure in peritoneal dialysis patients and body composition measured by dual-energy X-ray absorptiometry European Journal of Clinical Nutrition advance online publication, July 6 2016. doi:10.1038/ejcn.2016.120 Authors: S El-Kateb, S Sridharan, K Farrington & A Davenport from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29miQNF via IFTTT
The prebiotic concept and human health: a changing landscape with riboflavin as a novel prebiotic candidate?
The prebiotic concept and human health: a changing landscape with riboflavin as a novel prebiotic candidate? European Journal of Clinical Nutrition advance online publication, July 6 2016. doi:10.1038/ejcn.2016.119 Authors: R E Steinert, M S Sadabad, H J M Harmsen & amp; P Weber from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29NLEgA via IFTTT
Membrane progesterone receptors in reproduction and cancer
Publication date: 15 October 2016 Source:Molecular and Cellular Endocrinology, Volume 434 Author(s): Paulina Valadez-Cosmes, Edgar Ricardo Vázquez-Martínez, Marco Cerbón, Ignacio Camacho-Arroyo Progesterone is a sexual steroid hormone that has a critical role in reproductive processes in males and females of several species, including humans. Furthermore, progesterone has been associated with pathological diseases such as breast,… Continue reading Membrane progesterone receptors in reproduction and cancer
Low reversibility of intracellular cAMP accumulation in mouse Leydig tumor cells (MLTC-1) stimulated by human Luteinizing Hormone (hLH) and Chorionic Gonadotropin (hCG)
Publication date: 15 October 2016 Source:Molecular and Cellular Endocrinology, Volume 434 Author(s): Danièle Klett, Philippine Meslin, Lauriane Relav, Thi Mong Diep Nguyen, Julie Mariot, Gwenhaël Jégot, Claire Cahoreau, Yves Combarnous In order to study the intracellular cAMP response kinetics of Leydig cells to hormones with LH activity, we used MLTC-1 cells transiently expressing a chimeric… Continue reading Low reversibility of intracellular cAMP accumulation in mouse Leydig tumor cells (MLTC-1) stimulated by human Luteinizing Hormone (hLH) and Chorionic Gonadotropin (hCG)
Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression/activity in TM4 Sertoli cells
Publication date: 15 October 2016 Source:Molecular and Cellular Endocrinology, Volume 434 Author(s): Soledad P. Rossi, Stefanie Windschüttl, María E. Matzkin, Verónica Rey-Ares, Claudio Terradas, Roberto Ponzio, Elisa Puigdomenech, Oscar Levalle, Ricardo S. Calandra, Artur Mayerhofer, Mónica B. Frungieri Reactive oxygen species (ROS) regulate testicular function in health and disease. We previously described a prostaglandin D2… Continue reading Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression/activity in T... περισσότερα »
Gegenseitige Beeinflussung von Eltern und Babys in ihrem Schlafverhalten
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Zusammenfassung Hintergrund Im ersten Lebensjahr eines Kindes finden weitreichende Veränderungen des Schlafrhythmus statt. Dieser Entwicklungsprozess unterliegt biologischen Vorgängen, ist jedoch in hohem Maße abhängig von Umgebungsfaktoren und elterlichen Einflüssen. Fragestellung In diesem Review wird eine Verknüpfung zwischen kindlichem Schlaf und elterlichen Kognitionen, interaktivem Verhalten, Psychopathologien und Umgebungseinflüssen hergestellt. Material und Methoden Es erfolgt eine Literaturanalyse […]
Longitudinal changes in the dietary inflammatory index: an assessment of the inflammatory potential of diet over time in postmenopausal women
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Longitudinal changes in the dietary inflammatory index: an assessment of the inflammatory potential of diet over time in postmenopausal women European Journal of Clinical Nutrition advance online publication, July 6 2016. doi:10.1038/ejcn.2016.116 Authors: F K Tabung, S E Steck, J Zhang, Y Ma, A D Liese, F A Tylavsky, M Z Vitolins, J K Ockene […]
Different displacement of bioimpedance vector due to Ag/AgCl electrode effect
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Different displacement of bioimpedance vector due to Ag/AgCl electrode effect European Journal of Clinical Nutrition advance online publication, July 6 2016. doi:10.1038/ejcn.2016.121 Authors: L Nescolarde, H Lukaski, A De Lorenzo, B de-Mateo-Silleras, M P Redondo-del-Río & M A Camina-Martín from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29miHtE via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete […]
Consumption of soy foods and isoflavones and risk of type 2 diabetes: a pooled analysis of three US cohorts
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Consumption of soy foods and isoflavones and risk of type 2 diabetes: a pooled analysis of three US cohorts European Journal of Clinical Nutrition advance online publication, July 6 2016. doi:10.1038/ejcn.2016.117 Authors: M Ding, A Pan, J E Manson, W C Willett, V Malik, B Rosner, E Giovannucci, F B Hu & Q Sun from […]
Comparison of resting and total energy expenditure in peritoneal dialysis patients and body composition measured by dual-energy X-ray absorptiometry
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Comparison of resting and total energy expenditure in peritoneal dialysis patients and body composition measured by dual-energy X-ray absorptiometry European Journal of Clinical Nutrition advance online publication, July 6 2016. doi:10.1038/ejcn.2016.120 Authors: S El-Kateb, S Sridharan, K Farrington & A Davenport from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29miQNF via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 […]
The prebiotic concept and human health: a changing landscape with riboflavin as a novel prebiotic candidate?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The prebiotic concept and human health: a changing landscape with riboflavin as a novel prebiotic candidate? European Journal of Clinical Nutrition advance online publication, July 6 2016. doi:10.1038/ejcn.2016.119 Authors: R E Steinert, M S Sadabad, H J M Harmsen & amp; P Weber from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29NLEgA via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos […]
Membrane progesterone receptors in reproduction and cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 15 October 2016 Source:Molecular and Cellular Endocrinology, Volume 434 Author(s): Paulina Valadez-Cosmes, Edgar Ricardo Vázquez-Martínez, Marco Cerbón, Ignacio Camacho-Arroyo Progesterone is a sexual steroid hormone that has a critical role in reproductive processes in males and females of several species, including humans. Furthermore, progesterone has been associated with pathological diseases such as breast, […]
Low reversibility of intracellular cAMP accumulation in mouse Leydig tumor cells (MLTC-1) stimulated by human Luteinizing Hormone (hLH) and Chorionic Gonadotropin (hCG)
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 15 October 2016 Source:Molecular and Cellular Endocrinology, Volume 434 Author(s): Danièle Klett, Philippine Meslin, Lauriane Relav, Thi Mong Diep Nguyen, Julie Mariot, Gwenhaël Jégot, Claire Cahoreau, Yves Combarnous In order to study the intracellular cAMP response kinetics of Leydig cells to hormones with LH activity, we used MLTC-1 cells transiently expressing a chimeric […]
Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression/activity in TM4 Sertoli cells
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 15 October 2016 Source:Molecular and Cellular Endocrinology, Volume 434 Author(s): Soledad P. Rossi, Stefanie Windschüttl, María E. Matzkin, Verónica Rey-Ares, Claudio Terradas, Roberto Ponzio, Elisa Puigdomenech, Oscar Levalle, Ricardo S. Calandra, Artur Mayerhofer, Mónica B. Frungieri Reactive oxygen species (ROS) regulate testicular function in health and disease. We previously described a prostaglandin D2 […]
Brain-Derived Neurotrophic Factor in Children and Adolescents with Cirrhosis Due to Biliary Atresia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background: The nutritional status in patients with cirrhosis is not so easy to assess properly. Considering the relationship between brain-derived neurotrophic factor (BDNF) and energy homeostasis, the main aim of this study was to evaluate the concentration of BDNF in children and adolescents with cirrhosis due to biliary atresia (BA) and correlate it with their […]
Speech perception in medico-legal assessment of hearing disabilities.
*Speech perception in medico-legal assessment of hearing disabilities.* Int J Audiol. 2016 Jul 5;:1-9 Authors: Pedersen ER, Juhl PM, Wetke R, Ture Dammann Andersen Abstract OBJECTIVE: Examination of Danish data for medico-legal compensations regarding hearing disabilities. The study purposes are: (1) to investigate whether discrimination scores (DSs) relate to patients' subjective experience of their hearing and communication ability (the latter referring to audio-visual perception), (2) to compare DSs from different discrimination tests (auditory/audio-visual perception and witho... περισσότερα »
Using the Visual World Paradigm to Study Retrieval Interference in Spoken Language Comprehension.
*Using the Visual World Paradigm to Study Retrieval Interference in Spoken Language Comprehension.* Front Psychol. 2016;7:873 Authors: Sekerina IA, Campanelli L, Van Dyke JA Abstract The cue-based retrieval theory (Lewis et al., 2006) predicts that interference from similar distractors should create difficulty for argument integration, however this hypothesis has only been examined in the written modality. The current study uses the Visual World Paradigm (VWP) to assess its feasibility to study retrieval interference arising from distractors present in a visual display during spo... περισσότερα »
An Exploration of Rhythmic Grouping of Speech Sequences by French- and German-Learning Infants.
*An Exploration of Rhythmic Grouping of Speech Sequences by French- and German-Learning Infants.* Front Hum Neurosci. 2016;10:292 Authors: Abboub N, Boll-Avetisyan N, Bhatara A, Höhle B, Nazzi T Abstract Rhythm in music and speech can be characterized by a constellation of several acoustic cues. Individually, these cues have different effects on rhythmic perception: sequences of sounds alternating in duration are perceived as short-long pairs (weak-strong/iambic pattern), whereas sequences of sounds alternating in intensity or pitch are perceived as loud-soft, or high-low pairs (... περισσότερα »
What Pinnipeds Have to Say about Human Speech, Music, and the Evolution of Rhythm.
*What Pinnipeds Have to Say about Human Speech, Music, and the Evolution of Rhythm.* Front Neurosci. 2016;10:274 Authors: Ravignani A, Fitch WT, Hanke FD, Heinrich T, Hurgitsch B, Kotz SA, Scharff C, Stoeger AS, de Boer B Abstract Research on the evolution of human speech and music benefits from hypotheses and data generated in a number of disciplines. The purpose of this article is to illustrate the high relevance of pinniped research for the study of speech, musical rhythm, and their origins, bridging and complementing current research on primates and birds. We briefly discuss ... περισσότερα »
Temporally Regular Musical Primes Facilitate Subsequent Syntax Processing in Children with Specific Language Impairment.
*Temporally Regular Musical Primes Facilitate Subsequent Syntax Processing in Children with Specific Language Impairment.* Front Neurosci. 2016;10:245 Authors: Bedoin N, Brisseau L, Molinier P, Roch D, Tillmann B Abstract Children with developmental language disorders have been shown to be also impaired in rhythm and meter perception. Temporal processing and its link to language processing can be understood within the dynamic attending theory. An external stimulus can stimulate internal oscillators, which orient attention over time and drive speech signal segmentation to provide ... περισσότερα »
Behavioural and neurophysiological disruption of corticobulbar motor systems and their effects on sequential pharyngeal swallowing.
*Behavioural and neurophysiological disruption of corticobulbar motor systems and their effects on sequential pharyngeal swallowing.* Physiol Behav. 2016 Jul 1; Authors: Al-Toubi A, Daniels SK, Huckabee ML, Corey DM, Doeltgen SH Abstract Primary motor networks are known to be involved in the control of voluntary oral movements as well as the modulation of pharyngeal movements during experimentally controlled single swallows performed on command. The role of these networks in the more typical task of sequential swallowing remains unexplored. This study evaluated the hypothesis that... περισσότερα »
Intensity of language treatment: contribution to children's language outcomes.
*Intensity of language treatment: contribution to children's language outcomes.* Int J Lang Commun Disord. 2016 Jul 5; Authors: Schmitt MB, Justice LM, Logan JA Abstract BACKGROUND: Treatment intensity is an important factor in designing and delivering treatments to children with language impairment (LI). However, to date very little is understood about cumulative intervention intensity for children with LI in the US public school system. AIMS: To examine treatment intensity (dose: time spent on language; frequency: number of sessions; duration: one academic year) as delivered to ... περισσότερα »
The use of intracranial recordings to decode human language: Challenges and opportunities.
*The use of intracranial recordings to decode human language: Challenges and opportunities.* Brain Lang. 2016 Jul 1; Authors: Martin S, Millán JD, Knight RT, Pasley BN Abstract Decoding speech from intracranial recordings serves two main purposes: understanding the neural correlates of speech processing and decoding speech features for targeting speech neuroprosthetic devices. Intracranial recordings have high spatial and temporal resolution, and thus offer a unique opportunity to investigate and decode the electrophysiological dynamics underlying speech processing. In this revie... περισσότερα »
Relapse of pemphigus vulgaris after topical application of ingenol mebutate
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Ingenol mebutate is a recently approved topical agent for the treatment of actinic keratosis. Its most common adverse effects are transient local skin reactions. We report a 63-year-old white man who presented with a red–brownish crusted plaque involving the dorsum of his nose and an eroded area on his lower lip, which appeared soon […]
Harlequin ichthyosis: a novel compound mutation of ABCA12 with prenatal diagnosis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Harlequin ichthyosis (HI) is the most severe form of recessive congenital ichthyosis, and is frequently lethal. We describe a family with prenatal diagnosis of HI in two siblings. We applied genomic capture and massively parallel sequencing to detect all mutations in 20 genes, including ABCA12, with inherited mutations that predispose to congenital ichthyosis. Sequence […]
Cribriform neuroepithelial tumor (crinet): Molecular characterization of a smarcb1-deficient non-rhabdoid tumor with favorable long-term outcome
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Rhabdoid phenotype and loss of SMARCB1 expression in a brain tumor are characteristic features of atypical teratoid/rhabdoid tumors (ATRT). Rare non-rhabdoid brain tumors showing cribriform growth pattern and SMARCB1 loss have been designated cribriform neuroepithelial tumor (CRINET). Small case series suggest that CRINETs may have a relatively favorable prognosis. However, the long-term outcome is […]
Membrane progesterone receptors in reproduction and cancer
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: 15 October 2016 Source:Molecular and Cellular Endocrinology, Volume 434 Author(s): Paulina Valadez-Cosmes, Edgar Ricardo Vázquez-Martínez, Marco Cerbón, Ignacio Camacho-Arroyo Progesterone is a sexual steroid hormone that has a critical role in reproductive processes in males and females of several species, including humans. Furthermore, progesterone has been associated with pathological diseases such as breast, […]
Low reversibility of intracellular cAMP accumulation in mouse Leydig tumor cells (MLTC-1) stimulated by human Luteinizing Hormone (hLH) and Chorionic Gonadotropin (hCG)
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: 15 October 2016 Source:Molecular and Cellular Endocrinology, Volume 434 Author(s): Danièle Klett, Philippine Meslin, Lauriane Relav, Thi Mong Diep Nguyen, Julie Mariot, Gwenhaël Jégot, Claire Cahoreau, Yves Combarnous In order to study the intracellular cAMP response kinetics of Leydig cells to hormones with LH activity, we used MLTC-1 cells transiently expressing a chimeric […]
A Comparison of Combined Suprascapular and Axillary Nerve Blocks to Interscalene Nerve Block for Analgesia in Arthroscopic Shoulder Surgery: An Equivalence Study.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background and Objectives: The primary objective of this study was to compare the analgesic efficacy of combined suprascapular and axillary nerve block (SSAX) with interscalene block (ISB) after arthroscopic shoulder surgery. Our hypothesis was that ultrasound-guided SSAX would provide postoperative analgesia equivalent to ISB. Methods: Sixty adult patients undergoing arthroscopic shoulder surgery received either SSAX […]
Analgesic Effects of Ultrasound-Guided Serratus-Intercostal Plane Block and Ultrasound-Guided Intermediate Cervical Plexus Block After Single-Incision Transaxillary Robotic Thyroidectomy: A Prospective, Randomized, Controlled Trial.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background and Objectives: Single-incision transaxillary robotic thyroidectomy (START) requires substantial tissue disruption, which produces moderate-to-severe pain in the axilla and neck areas during the early postoperative period. This study aimed to investigate the analgesic effects of ultrasound-guided serratus-intercostal plane blocks and intermediate cervical plexus blocks (CPBs) on the early postoperative pain after START. Methods: We […]
The Impact of Neuraxial Versus General Anesthesia on the Incidence of Postoperative Surgical Site Infections Following Knee or Hip Arthroplasty: A Meta-Analysis.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background: Recent studies have yielded conflicting results on the association between anesthesia technique and incidence of postoperative surgical site infections (SSIs) after knee arthroplasty (KA) and hip arthroplasty (HA). Our group conducted a meta-analysis of all available studies to clarify this potential association. Methods: Our group searched MEDLINE, EMBASE, and Google Scholar for all relevant […]
Evaluation of the route dependency of the pharmacokinetics and neuro-pharmacokinetics of tramadol and its main metabolites in rats
Publication date: 20 September 2016 *Source:*European Journal of Pharmaceutical Sciences, Volume 92 Author(s): Behjat Sheikholeslami, Mahdi Gholami, Hoda Lavasani, Mohammadreza Rouini Tramadol hydrochloride is a centrally acting analgesic used for the treatment of moderate-to-severe pain. It has three main metabolites: O-desmethyltramadol (M1), N-desmethyltramadol (M2), and N,O-didesmethyltramadol (M5). Because of the frequent use of tramadol by patients and drug abusers, the ability to determine the parent drug and its metabolites in plasma and cerebrospinal fluid is of great impor... περισσότερα »
Phenylbutyrate exerts adverse effects on liver regeneration and amino acid concentrations in partially hepatectomized rats
Summary Phenylbutyrate is recommended in urea cycle disorders and liver injury to enhance nitrogen disposal by the urine. However, hypothetically there may be adverse responses to the use of phenylbutyrate in the treatment of liver disease because of its role as a histone deacetylase inhibitor and its stimulatory effect on branched-chain alpha-keto acid dehydrogenase, the rate-limiting enzyme in the catabolism of branched-chain amino acids (BCAA; valine, leucine and isoleucine). We report the effects of phenylbutyrate on liver regeneration and amino acid levels in plasma of partial... περισσότερα »
Hypofractionated Intensity-Modulated Radiotherapy for Patients With Non-Small-Cell Lung Cancer.
*Hypofractionated Intensity-Modulated Radiotherapy for Patients With Non-Small-Cell Lung Cancer.* Clin Lung Cancer. 2016 Jun 8; Authors: Pollom EL, Qian Y, Durkee BY, von Eyben R, Maxim PG, Shultz DB, Gensheimer M, Diehn M, Loo BW Abstract BACKGROUND: Alternative treatment regimens are needed for patients with non-small cell lung cancer (NSCLC) who cannot receive definitive treatment with concurrent chemoradiotherapy, surgery, or stereotactic ablative radiotherapy (SABR). PATIENTS AND METHODS: We report survival, patterns of failure and toxicity outcomes for patients with NSCLC w... περισσότερα »
CD80 down-regulation is associated to aberrant DNA methylation in non-inflammatory colon carcinogenesis.
*CD80 down-regulation is associated to aberrant DNA methylation in non-inflammatory colon carcinogenesis.* BMC Cancer. 2016;16(1):388 Authors: Scarpa M, Scarpa M, Castagliuolo I, Erroi F, Basato S, Brun P, Angriman I, Castoro C Abstract BACKGROUND: The lack of positive costimulatory molecules represents one of the mechanisms by which tumor cells evade immune surveillance. Promoter hypermethylation plays a major role in cancer development through transcriptional silencing of critical genes. The aim of this study was to examine the expression of the costimulatory molecule CD80 in r... περισσότερα »
Choroidal melanoma treated with stereotactic fractionated radiotherapy and prophylactic intravitreal bevacizumab: The Dunedin Hospital experience.
*Choroidal melanoma treated with stereotactic fractionated radiotherapy and prophylactic intravitreal bevacizumab: The Dunedin Hospital experience.* J Med Imaging Radiat Oncol. 2016 Jul 5; Authors: Haji Mohd Yasin NA, Gray AR, Bevin TH, Kelly LE, Molteno AC Abstract INTRODUCTION: Choroidal melanoma (CM) is the most common primary ocular malignancy in adults. This study reviewed the Dunedin Hospital (DH) experience in the treatment of CM with stereotactic fractionated radiotherapy (SRT) and the outcome of prophylactic use of intravitreal injection bevacizumab (PIB) in preventing ra... περισσότερα »
KSP inhibitor SB743921 inhibits growth and induces apoptosis of breast cancer cells by regulating p53, Bcl-2, and DTL.
*KSP inhibitor SB743921 inhibits growth and induces apoptosis of breast cancer cells by regulating p53, Bcl-2, and DTL.* Anticancer Drugs. 2016 Jul 1; Authors: Zhu L, Xiao F, Yu Y, Wang H, Fang M, Yang Y, Sun H, Wang L, Sheng Y Abstract Kinesin spindle protein (KSP) is a microtubule-associated motor protein that is specifically expressed by mitosis cells. It is highly expressed in various types of tumors including hematomalignances and solid tumors. Chemical KSP inhibition has become a novel strategy in the development of anticancer drugs. SB743921 is a selective inhibitor for KSP... περισσότερα »
G protein-coupled estrogen receptor enhances melanogenesis via cAMP-protein kinase (PKA) by upregulating microphthalmia-related transcription factor-tyrosinase in melanoma.
*G protein-coupled estrogen receptor enhances melanogenesis via cAMP-protein kinase (PKA) by upregulating microphthalmia-related transcription factor-tyrosinase in melanoma.* J Steroid Biochem Mol Biol. 2016 Jul 1; Authors: Sun M, Xie HF, Tang Y, Lin SQ, Li JM, Sun SN, Hu XL, Huang YX, Shi W, Jian D Abstract OBJECTIVE: This study investigated the role and mechanism of action of G protein-coupled estrogen receptor (GPER) in melanogenesis. METHODS: GPER expression was detected in the A375 human melanoma cell line and B16 mouse melanoma cell line. Cell proliferation, melanin content,... περισσότερα »
Safety, immune and clinical responses in metastatic melanoma patients vaccinated with a long peptide derived from indoleamine 2,3-dioxygenase in combination with ipilimumab.
*Safety, immune and clinical responses in metastatic melanoma patients vaccinated with a long peptide derived from indoleamine 2,3-dioxygenase in combination with ipilimumab.* Cytotherapy. 2016 Aug;18(8):1043-1055 Authors: Bjoern J, Iversen TZ, Nitschke NJ, Andersen MH, Svane IM Abstract BACKGROUND AIM: Indoleamine 2,3-dioxygenase (IDO) is an emerging new target in cancer therapy that can be targeted with active immunotherapy (e.g. through peptide vaccination). Furthermore, IDO has been identified as a key mechanism underlying resistance to treatment with the checkpoint blocking ... περισσότερα »
A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.
*A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.* Nat Commun. 2016;7:12105 Authors: Gao Y, Mutter-Rottmayer E, Greenwalt AM, Goldfarb D, Yan F, Yang Y, Martinez-Chacin RC, Pearce KH, Tateishi S, Major MB, Vaziri C Abstract Trans-lesion synthesis (TLS) is an important DNA-damage tolerance mechanism that permits ongoing DNA synthesis in cells harbouring damaged genomes. The E3 ubiquitin ligase RAD18 activates TLS by promoting recruitment of Y-family DNA polymerases to sites of DNA-damage-induced replication fork stalling. Here we identify the cancer/tes... περισσότερα »
Profiling networks of distinct immune-cells in tumors.
*Profiling networks of distinct immune-cells in tumors.* BMC Bioinformatics. 2016;17(1):263 Authors: Clancy T, Hovig E Abstract BACKGROUND: It is now clearly evident that cancer outcome and response to therapy is guided by diverse immune-cell activity in tumors. Presently, a key challenge is to comprehensively identify networks of distinct immune-cell signatures present in complex tissue, at higher-resolution and at various stages of differentiation, activation or function. This is particularly so for closely related immune-cells with diminutive, yet critical, differences. RESULT... περισσότερα »
IGFBP-3 inhibits Wnt signalling in metastatic melanoma cells.
*IGFBP-3 inhibits Wnt signalling in metastatic melanoma cells.* Mol Carcinog. 2016 Jul 5; Authors: Antimo N, Maria Z, Laura S, Vincenzo P, Dorina P, Marianna M, Rana RA, Paola L Abstract In previous works, we showed that Insulin-like-Growth-Factor-Binding-Protein-3 (IGFBP-3), a tissue and circulating protein able to bind to IGFs, decreases drastically in the blood serum of patients with diffuse metastatic melanoma. In agreement with the clinical data, recombinant IGFBP-3 was found to inhibit the motility and invasiveness of cultured metastatic melanoma cells and to prevent growt... περισσότερα »
Molecular profiling of immune activation associated with regression of melanoma metastases induced by diphencyprone.
*Molecular profiling of immune activation associated with regression of melanoma metastases induced by diphencyprone.* J Invest Dermatol. 2016 Jul 1; Authors: Gulati N, Garcet S, Fuentes-Duculan J, Gilleaudeau P, Sullivan-Whalen M, Li X, Suárez-Fariñas M, Coit DG, Krueger JG PMID: 27377699 [PubMed - as supplied by publisher] from Melanoma via xlomafota13 on Inoreader http://ift.tt/29NK66u
Pembrolizumab: first experience with recurrent primary central nervous system (CNS) tumors.
*Pembrolizumab: first experience with recurrent primary central nervous system (CNS) tumors.* J Neurooncol. 2016 Jul 4; Authors: Blumenthal DT, Yalon M, Vainer GW, Lossos A, Yust S, Tzach L, Cagnano E, Limon D, Bokstein F Abstract Patients with progressive primary brain tumors (PBT) are attracted to promising new treatments, even prior to convincing data. Anti-PD1 immunotherapies have been in the spotlight since publication of groundbreaking results for metastatic melanoma with pembrolizumab (PBL). Our objective was to report on the response and toxicity of PBL in patients with ... περισσότερα »
Adoptive transfer of natural killer cells promotes the anti-tumor efficacy of T cells.
*Adoptive transfer of natural killer cells promotes the anti-tumor efficacy of T cells.* Clin Immunol. 2016 Jul 1; Authors: Goding SR, Yu S, Bailey LM, Lotze MT, Basse PH Abstract The density of NK cells in tumors correlates positively with prognosis in many types of cancers. The average number of infiltrating NK cells is, however, quite modest (approximately 30 NK cells/sq.mm), even in tumors deemed to have a "high" density of infiltrating NK cells. It is unclear how such low numbers of tumor-infiltrating NK cells can influence outcome. Here, we used ovalbumin-expressing tumor c... περισσότερα »
Risk of second primary malignancies among cancer survivors in the United States, 1992 through 2008.
*Risk of second primary malignancies among cancer survivors in the United States, 1992 through 2008.* Cancer. 2016 Jul 5; Authors: Donin N, Filson C, Drakaki A, Tan HJ, Castillo A, Kwan L, Litwin M, Chamie K Abstract BACKGROUND: In the current study, the authors attempted to describe the incidence, most common sites, and mortality of second primary malignancies among survivors of common cancers. METHODS: The authors identified patients aged ≥18 years who were diagnosed with a primary malignancy from the 10 most common cancer sites (prostate, breast, lung, colon, rectum, bladder, ... περισσότερα »
Comparing survival of patients with single or multiple primary melanoma in The Netherlands: 1994-2009.
*Comparing survival of patients with single or multiple primary melanoma in The Netherlands: 1994-2009.* Br J Dermatol. 2016 Jul 5; Authors: Pardo LM, van der Leest RJ, de Vries E, Soerjomataram I, Nijsten T, Hollestein LM Abstract In the Netherlands the incidence of melanoma has been increasing whilst melanoma survival has improved significantly in the last 20 years(1) . As a result, there is an increasing number of melanoma survivors, who are at increased risk of developing new melanomas(2) . There is limited and conflicting literature concerning the survival of patients with m... περισσότερα »
Spirituality and mood pathology in severe skin conditions: a prospective observational study.
*Spirituality and mood pathology in severe skin conditions: a prospective observational study.* Arch Dermatol Res. 2016 Jul 4; Authors: Unterrainer HF, Lukanz M, Pilch M, Scharf S, Glawischnig-Goschnik M, Wutte N, Fink-Puches R, Aberer E Abstract Although the association between spirituality and parameters of psychological health and disease has been investigated extensively, little evidence is available for its potential role in dermatology. In a single-centre observational prospective study, 149 outpatients (107 women) with systemic sclerosis (SSc; n = 44), lupus erythematosus ... περισσότερα »
Detection of Molecular Alterations in Medullary Thyroid Carcinoma Using Next-Generation Sequencing: an Institutional Experience.
*Detection of Molecular Alterations in Medullary Thyroid Carcinoma Using Next-Generation Sequencing: an Institutional Experience.* Endocr Pathol. 2016 Jul 5; Authors: Wei S, LiVolsi VA, Montone KT, Morrissette JJ, Baloch ZW Abstract Medullary thyroid carcinoma (MTC) harbors rearranged during transfection (RET) gene and rarely RAS gene mutations. The knowledge of the type of gene mutation in MTC is important to determine the treatment of the patients and the management of their family members. Targeted next-generation sequencing with a panel of 47 genes was performed in a total of ... περισσότερα »
Safety, complications and patients' acceptance of Mohs micrographic surgery (MMS) under local anaesthesia - results from the UK MAPS (Mohs Acceptance and Patient Safety) Collaboration Group.
*Safety, complications and patients' acceptance of Mohs micrographic surgery (MMS) under local anaesthesia - results from the UK MAPS (Mohs Acceptance and Patient Safety) Collaboration Group.* Br J Dermatol. 2016 Jul 5; Authors: Hussain W, Affleck A, Al-Niaimi F, Cooper A, Craythorne E, Fleming C, Ghura V, Langtry J, Lawrence C, Loghdey S, Naysmith L, Oliphant T, Rahim R, Rice S, Sivaramkrishan M, Stables G, Varma S, Mallipeddi R Abstract By virtue of its tissue sparing properties and assessment of 100% of the margin of excised specimens, MMS is regarded as the gold-standard surgi... περισσότερα »
Acute Lower Limb Ischaemia and Diabetes in a Patient Treated with Anti-PD1 Monoclonal Antibody for Metastatic Melanoma.
*Acute Lower Limb Ischaemia and Diabetes in a Patient Treated with Anti-PD1 Monoclonal Antibody for Metastatic Melanoma.* Acta Derm Venereol. 2016 Jul 5; Authors: Thoreau B, Gouaillier-Vulcain F, Machet L, Mateus C, Robert C, Ferreira-Maldent N, Maillot F, Lioger B Abstract is missing (SHort communication). PMID: 27377178 [PubMed - as supplied by publisher] from Melanoma via xlomafota13 on Inoreader http://ift.tt/29mh5ju
Effects of Radioactive Iodine Ablation Therapy on Voice Quality.
*Effects of Radioactive Iodine Ablation Therapy on Voice Quality.* J Voice. 2016 Jul 1; Authors: Aydoğdu İ, Atar Y, Saltürk Z, Sarı H, Ataç E, Aydoğdu Z, İnan M, Mersinlioğlu G, Uyar Y Abstract OBJECTIVE: The goal of this study was to evaluate the effects of radioactive iodine ablation therapy on voice quality of patients diagnosed with well-differentiated thyroid carcinoma. METHODS: We enrolled 36 patients who underwent total or subtotal thyroidectomy due to well-differentiated thyroid carcinoma. Voice recordings from patients were analyzed for acoustic and aerodynamic voice. Th... περισσότερα »
Fe de errores a «Metástasis laríngea de melanoma lentiginoso acral: imágenes de banda estrecha»
[image: alertIcon.gif] Publication date: July–August 2016 *Source:*Acta Otorrinolaringológica Española, Volume 67, Issue 4 Author(s): Eulalia Porras Alonso, Blidy Noemith Añaguari Torres, Miguel Alberto Rodríguez Pérez from Melanoma via xlomafota13 on Inoreader http://ift.tt/29pJZQb
Remarkable response in 2 cases of Advanced Poorly Differentiated Thyroid Carcinoma with liposomal doxorubicin plus cisplatin
Volume 17, Issue 6, June 2016, pages 693-697<br>10.1080/15384047.2016.1167295<br>Haiyan Yang from thyroid via a.lsfakia on Inoreader http://ift.tt/29w1ikY via IFTTT
Cost-Effectiveness of Antibody-Based Induction Therapy in Deceased Donor Kidney Transplantation in the United States.
Background: Induction therapy in deceased donor kidney transplantation is costly, with wide discrepancy in utilization and a limited evidence base, particularly regarding cost-effectiveness. Methods: We linked the United States Renal Data System data set to Medicare claims to estimate cumulative costs, graft survival, and incremental cost-effectiveness ratio (ICER - cost per additional year of graft survival) within 3 years of transplantation in 19 450 deceased donor kidney transplantation recipients with Medicare as primary payer from 2000 to 2008. We divided the study cohort into ... περισσότερα »
Decreased Circulating Sclerostin Levels in Renal Transplant Recipients With Persistent Hyperparathyroidism.
Background: Sclerostin is an osteocyte-secreted soluble antagonist of the Wnt/[beta]-catenin signaling pathway requisite for osteoblast development and activity. The regulation of sclerostin expression in bone is complex. Parathyroid hormone (PTH) is recognized to be an important suppressor. Circulating sclerostin levels are 2- to 4-fold higher in patients with end-stage renal disease as compared with individuals with normal renal function. Methods: We performed a longitudinal observational cohort study and case-control study in 50 de novo renal transplant recipients, 50 chronic kid... περισσότερα »
Center Volume Is Associated With Outcome After Pancreas Transplantation Within the Eurotransplant Region.
Introduction: Outcome after surgery depends on several factors, among these, the annual volume-outcome relationship. This might also be the case in a highly complex field as pancreas transplantation. No study has investigated this relationship in a European setting. Methods: All consecutive pancreas transplantations from January 2008 until December 2013 were included. Donor-, recipient-, and transplant-related factors were analyzed for their association with patient and graft survivals. Centers were classified in equally sized groups as being low volume (=13/year). Results: In the s... περισσότερα »
Nursery policies on conjunctivitis may encourage GPs to prescribe antibiotics
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Nurseries’ policies excluding children with acute infective conjunctivitis until they recover or have been treated mean that GPs are pressurised by parents to prescribe antibiotics for children who… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29m76e2 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Switching older people to a pill organiser could increase adverse events, researchers warn
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Switching to a pill organiser could, somewhat surprisingly, cause older people to experience more adverse events, and patients should consult their GP or pharmacist before making this change, a… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29NxHzg via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Expression of astrocyte elevated gene-1 protein in ameloblastomas, keratocystic odontogenic tumors, and dentigerous cysts
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background Benign epithelial odontogenic tumors such as ameloblastoma and keratocystic odontogenic tumor (KCOT) may exhibit an aggressive clinical course reminiscent of malignancies. Recent studies have indicated that astrocyte elevated gene-1 (AEG-1) is highly expressed in a variety of malignant neoplasms and its overexpression is associated with tumor invasion, metastasis, and poor survival. However, the role […]
Genetic profile of PTEN gene in Indian oral squamous cell carcinoma primary tumors
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background Phosphatase and tensin homolog (PTEN) is the tumor suppressor gene located on chromosome10q23.3. Genetic variations in the PTEN gene have been found in various sporadic tumors. However, petite is known about the genetic profile of the PTEN gene in oral squamous cell carcinoma (OSCC), which is the eighth most common neoplasm worldwide and leading […]
Brain-Derived Neurotrophic Factor in Children and Adolescents with Cirrhosis Due to Biliary Atresia
Background: The nutritional status in patients with cirrhosis is not so easy to assess properly. Considering the relationship between brain-derived neurotrophic factor (BDNF) and energy homeostasis, the main aim of this study was to evaluate the concentration of BDNF in children and adolescents with cirrhosis due to biliary atresia (BA) and correlate it with their… Continue reading Brain-Derived Neurotrophic Factor in Children and Adolescents with Cirrhosis Due to Biliary Atresia
Finding Harappan seal carvers: An operational sequence approach to identifying people in the past
Publication date: August 2016 Source:Journal of Archaeological Science, Volume 72 Author(s): Adam S. Green The engravings on Harappan stamp seals allow the identification of particular artisans in the past. Toward this end, this article employs three-dimensional optical microscopy of stamp seal engravings to provide a non-destructive source of data for reconstructing specific sequences of action.… Continue reading Finding Harappan seal carvers: An operational sequence approach to identifying people in the past
Fe de errores a «Metástasis laríngea de melanoma lentiginoso acral: imágenes de banda estrecha»
Publication date: July–August 2016 Source:Acta Otorrinolaringológica Española, Volume 67, Issue 4 Author(s): Eulalia Porras Alonso, Blidy Noemith Añaguari Torres, Miguel Alberto Rodríguez Pérez from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29pJZQb via IFTTT
Fe de errores a «Metástasis laríngea de melanoma lentiginoso acral: imágenes de banda estrecha»
Publication date: July–August 2016 Source:Acta Otorrinolaringológica Española, Volume 67, Issue 4 Author(s): Eulalia Porras Alonso, Blidy Noemith Añaguari Torres, Miguel Alberto Rodríguez Pérez from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/29pJZQb via IFTTT
Neoadjuvant radiotherapy plus radical surgery for locally advanced stage III/IV oral cancer: Analysis of prognostic factors affecting overall survival
Publication date: September 2016 Source:Oral Oncology, Volume 60 Author(s): Eder-Czembirek Christina, Czembirek Cornelia, Selzer Edgar ObjectivesPreoperative radiotherapy followed by surgery is an effective treatment option for solid tumors including locally advanced squamous cell cancers of the head and neck region. Histopathologic response to radiation has been shown to be associated with survival. However, the relative… Continue reading Neoadjuvant radiotherapy plus radical surgery for locally advanced stage III/IV oral cancer: Analysis of prognostic factors affecting overall sur... περισσότερα »
Prognostic efficacy of combining tumor volume with Epstein-Barr virus DNA in patients treated with intensity-modulated radiotherapy for nasopharyngeal carcinoma
Publication date: September 2016 Source:Oral Oncology, Volume 60 Author(s): Lixia Lu, Jiaxin Li, Chong Zhao, Wenqiong Xue, Fei Han, Tang Tao, Hui Chang, Weihua Jia, Taixiang Lu ObjectivesTo evaluate the prognostic effect of combining tumor volume with pre-treatment plasma Epstein-Barr virus DNA (EBV DNA) in patients treated with intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC).Materials… Continue reading Prognostic efficacy of combining tumor volume with Epstein-Barr virus DNA in patients treated with intensity-modulated radiotherapy for nasopharyngeal carci... περισσότερα »
Possible interaction between tobacco use and EBV in oral squamous cell carcinoma
Publication date: Available online 20 June 2016 Source:Oral Oncology Author(s): Nezar N. Al-hebshi, Akram T. Nasher, David J. Speicher, Mushfiq H. Shaikh, Newell W. Johnson from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29m9Xnx via IFTTT
Nonlinear association between betel quid chewing and oral cancer: Implications for prevention
Publication date: September 2016 Source:Oral Oncology, Volume 60 Author(s): Sreenath Arekunnath Madathil, Marie-Claude Rousseau, Willy Wynant, Nicolas F. Schlecht, Gopalakrishnan Netuveli, Eduardo L. Franco, Belinda Nicolau PurposeBetel quid chewing is a major oral cancer risk factor and the human papillomaviruses (HPV) may play an aetiological role in these cancers. However, little is known about the… Continue reading Nonlinear association between betel quid chewing and oral cancer: Implications for prevention
Predictors of severe long-term toxicity after re-irradiation for head and neck cancer
Publication date: September 2016 Source:Oral Oncology, Volume 60 Author(s): Jae Y. Lee, Krithika Suresh, Rebecca Nguyen, Eli Sapir, Janell S. Dow, George S. Arnould, Francis P. Worden, Matthew E. Spector, Mark E. Prince, Scott A. McLean, Andrew G. Shuman, Kelly M. Malloy, Keith Casper, Carol R. Bradford, Matthew J. Schipper, Avraham Eisbruch ObjectiveTo identify predictive… Continue reading Predictors of severe long-term toxicity after re-irradiation for head and neck cancer
Development and validation of Raman spectroscopic classification models to discriminate tongue squamous cell carcinoma from non-tumorous tissue
Publication date: September 2016 Source:Oral Oncology, Volume 60 Author(s): Froukje L.J. Cals, Senada Koljenović, José A. Hardillo, Robert J. Baatenburg de Jong, Tom C. Bakker Schut, Gerwin J. Puppels BackgroundCurrently, up to 85% of the oral resection specimens have inadequate resection margins, of which the majority is located in the deeper soft tissue layers. The… Continue reading Development and validation of Raman spectroscopic classification models to discriminate tongue squamous cell carcinoma from non-tumorous tissue
Chemokines accentuating protumoral activities in oral cancer microenvironment possess an imperious stratagem for therapeutic resolutions
Publication date: September 2016 Source:Oral Oncology, Volume 60 Author(s): Swagatika Panda, Subrat Kumar Padhiary, Samapika Routray Chemokines, the chemotactic cytokines have established their role in tumorigenesis and tumor progression. Studies, which explored their role in oral cancer for protumoral activity, point towards targeting chemokines for oral squamous cell carcinoma therapy. The need of the hour… Continue reading Chemokines accentuating protumoral activities in oral cancer microenvironment possess an imperious stratagem for therapeutic resolutions
Oral cancer during pregnancy
Publication date: Available online 2 July 2016 Source:Oral Oncology Author(s): Valentina Terenzi, Andrea Cassoni, Marco Della Monaca, Paolo Priore, Francesca De Felice, Daniela Musio, Andrea Battisti, Maria Teresa Fadda, Vincenzo Tombolini, Valentino Valentini from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29NBJrq via IFTTT
New approach for virtual surgical planning and mandibular reconstruction using a fibula free flap
Publication date: Available online 22 June 2016 Source:Oral Oncology Author(s): Matthias Mottini, S.M. Seyed Jafari, Maziar Shafighi, Benoît Schaller Maxillofacial reconstruction poses a major challenge to surgeons because of the associated anatomical complexity, the sensitivity of the involved systems and the need to maintain a pleasing facial appearance. Here, we present a detailed description of… Continue reading New approach for virtual surgical planning and mandibular reconstruction using a fibula free flap
Unmet needs for patients with salivary gland cancer
Publication date: Available online 1 July 2016 Source:Oral Oncology Author(s): Lara A. Dunn, Alan L. Ho, Scott A. Laurie, David G. Pfister from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29NC91b via IFTTT
Prognostic significance of p53 expression in patients with esophageal cancer: A meta-analysis
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
BMC Cancer from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29mb9qJ via IFTTT
Genetic predisposition to obesity is associated with insulin secretion in Chinese adults: The Cardiometabolic Risk in Chinese (CRC) study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Journal of Diabetes and its Complications from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29ND7dJ via IFTTT
The Chinese medicine Kuan-Sin-Yin improves liver function in patients with chronic hepatitis C: A randomised and placebo-controlled trial
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Complementary Therapies in Medicine from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29mbqdr via IFTTT
Advantages of radial volumetric breath-hold examination (VIBE) with k-space weighted image contrast reconstruction (KWIC) over Cartesian VIBE in liver imaging of volunteers simulating inadequate or no breath-holding ability
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
European Radiology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29NDFQZ via IFTTT
Celiac disease: Understanding the gluten-free diet
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
European Journal of Nutrition from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29mbmue via IFTTT
Pharmacologic provocation combined with endoscopy in refractory cases of GI bleeding
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Gastrointestinal Endoscopy from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29NDuVH via IFTTT
Efficacy observation on acupuncture for diabetic gastroparesis
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Journal of Acupuncture and Tuina Science from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29mb9aw via IFTTT
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