Head and Neck Medicine by Alexandros G.Sfakianakis: 05/05/16

Πέμπτη 5 Μαΐου 2016

OtoRhinoLaryngology & Medicine,New Articles,May 6th,2016

Lavender angustifolia Essential Oil and Its Active Constituents on the Proliferation of Human Prostate Cancer

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 10 δευτερόλεπτα

Lavandula angustifolia is the most widely cultivated Lavandula species. The extraction of its flower and leaves has been used as herbal medicine. In this study, the in vitro antitumor activities were tested on human prostate cancer PC-3 and DU145 cell lines. Flow cytometry technology was applied to study apoptosis induction and cell cycle arrest. The […]

Exercise Training for Patients Pre- and Postsurgically Treated for Non-Small Cell Lung Cancer: A Systematic Review and Meta-analysis

Background. This meta-analysis examined the effects of exercise training on length of hospital stay, postoperative complications, exercise capacity, 6-minute walking distance (6MWD), and health-related quality of life (HRQoL) in patients following resection of non–small cell lung cancer (NSCLC). Methods. This review searched PubMed, EMBASE, and the Cochrane Collaboration data base up to August 16, 2015. […]

Probiotic Survey in Cancer Patients Treated in the Outpatient Department in a Comprehensive Cancer Center

Purpose. Availability without prescription restriction, low cost, and simple oral administration allow cancer patients to use probiotics without knowledge of potential risks. We present a survey of probiotic use and the association with patient tumor characteristics in cancer patients treated at the outpatient department of the National Cancer Institute in Slovakia. Patients and Methods. Between […]

Synergistic Apoptotic Effect of D-Fraction From Grifola frondosa and Vitamin C on Hepatocellular Carcinoma SMMC-7721 Cells

The aim of this study was to investigate the anticancer effect of a combination of D-fraction polysaccharide from Grifola frondosa (DFP) and vitamin C (VC) on hepatocellular carcinoma in vitro. DFP is a bioactive extract from the maitake mushroom. Anticancer activity was demonstrated using various concentrations of DFP alone or in combination with VC against […]

Meta-Analysis of the Effects of Neuropsychological Interventions on Cognitive Function in Non-Central Nervous System Cancer Survivors

Background. Cognitive impairment is a common complaint among cancer survivors, significantly impacting working memory, attention, executive function, and information processing speed. This meta-analysis aims to evaluate the effect of neuropsychological interventions on the cognitive function of non–central nervous system (non-CNS) cancer survivors. Methods. Three databases (PubMed, PsycInfo, and CAJ Full-text Database) were searched from January […]

Survival Analysis of Advanced Non-Small Cell Lung Cancer Patients Treated by Using Wheel Balance Cancer Therapy

Objective. To investigate the clinical effect and the overall survival (OS) rate of patients with advanced non–small cell lung cancer (NSCLC) who have undergone Wheel Balance Cancer Therapy (WBCT). Methods. The cases of 33 patients with advanced NSCLC who were treated with WBCT at the East West Cancer Center (EWCC) between October 4, 2004, and […]

Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA): A Feasibility Study

Introduction. Surgical resection in patients with non–small cell lung cancer (NSCLC) may be associated with significant morbidity, functional limitations, and decreased quality of life. Objectives. The safety and feasibility of a preoperative and early postoperative rehabilitation program in patients operated for NSCLC was determined in a nonhospital setting, with focus on high-intensity interval exercise. Methods. […]

Complementary and Alternative Medicine Use at a Comprehensive Cancer Center

Background. Complementary and alternative medicine (CAM) use is common among cancer patients, but the majority of CAM studies do not specify the time periods in relation to cancer diagnoses. We sought to define CAM use by cancer patients and investigate factors that might influence changes in CAM use in relation to cancer diagnoses. Methods. We […]

Chemopreventive Activity of MGN-3/Biobran Against Chemical Induction of Glandular Stomach Carcinogenesis in Rats and Its Apoptotic Effect in Gastric Cancer Cells

In the current study, we investigated the chemopreventive activity of arabinoxylan rice bran, MGN-3/Biobran, against chemical induction of glandular stomach carcinogenesis in rats. Gastric cancer was induced by carcinogen methylnitronitrosoguanidine (MNNG), and rats received MNNG alone or MNNG plus Biobran (40 mg/kg body weight) for a total of 8 months. Averaged results from 2 separate […]

Individualized Integrative Cancer Care in Anthroposophic Medicine: A Qualitative Study of the Concepts and Procedures of Expert Doctors

Background. Cancer patients widely seek integrative oncology which embraces a wide variety of treatments and system approaches. Objective. To investigate the concepts, therapeutic goals, procedures, and working conditions of integrative oncology doctors in the field of anthroposophic medicine. Methods. This qualitative study was based on in-depth interviews with 35 highly experienced doctors working in hospitals […]

HDACi Sensitize Myeloma Cells to Reovirus

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα

Multiple myeloma remains incurable and the majority of patients die within 5 years of diagnosis. Reolysin, the infusible form of human reovirus (RV), is a novel viral oncolytic therapy associated with antitumor activity likely resulting from direct oncolysis and a virus-mediated antitumor immune response. Results from our phase I clinical trial investigating single agent Reolysin […]

Hyperpolarized 13C MRSI-Detectable Changes with GBM Treatment

The current standard of care for glioblastoma (GBM) is surgical resection, radiotherapy, and treatment with temozolomide (TMZ). However, resistance to current therapies and recurrence are common. To improve survival, agents that target the PI3K signaling pathway, which is activated in approximately 88% of GBM, are currently in clinical trials. A challenge with such therapies is […]

SAHA Enhances Radiosensitization of Cisplatin in Lung Cancer

Lung cancer is a leading cause of cancer-related mortality worldwide, and concurrent chemoradiotherapy has been explored as a therapeutic option. However, the chemotherapeutic agents cannot be administered for most patients at full doses safely with radical doses of thoracic radiation, and further optimizations of the chemotherapy regimen to be given with radiation are needed. In […]

Bortezomib Inhibits Giant Cell Tumor of Bone

Giant cell tumor of bone (GCTB) is a rare and highly osteolytic bone tumor that usually leads to an extensive bone lesion. The purpose of this study was to discover novel therapeutic targets and identify potential agents for treating GCTB. After screening the serum cytokine profiles in 52 GCTB patients and 10 normal individuals using […]

Immunokinase-Based B-Lymphotoxic Delivery of Activated DAPK1

The serine/threonine death-associated protein kinases (DAPK) provide pro-death signals in response to (oncogenic) cellular stresses. Lost DAPK expression due to (epi)genetic silencing is found in a broad spectrum of cancers. Within B-cell lymphomas, deficiency of the prototypic family member DAPK1 represents a predisposing or early tumorigenic lesion and high-frequency promoter methylation marks more aggressive diseases. […]

Physiological and psychological factors associated with onset of high-altitude headache in Chinese men upon acute high-altitude exposure at 3700 m

Aim We aimed to identify clinical characteristics and risk factors associated with onset of high-altitude headache (HAH) after acute exposure at 3700 m. Method In two hours, 163 individuals ascended by plane to 3700 m. Demographic information, physiological and psychological measurements, cognitive function, physical work capacity tests and profile of mood states within one week […]

Sphenopalatine ganglion stimulation in cluster headache and other types of headache

Objectives The cluster headache is the most excruciatingly painful primary headache. In some patients, neither preventive treatment nor acute treatment is effective or treatment is poorly tolerated. The sphenopalatine ganglion (SPG) has an important role in the pathophysiology of cluster headache and, for this reason, SPG stimulation has been used to treat cluster headache. Methods […]

Can the border of migraine with aura be safely extended?

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Sonographic evaluation of lumbar interlaminar space opening in a variety of patient body positions for optimal neuraxial anesthesia delivery

Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 9 δευτερόλεπτα

[image: gr1.sml] To find the position that provided the most comfort, as well as the widest L3-L4 interlaminar space opening. from Anaesthesia via ola Kala on Inoreader http://ift.tt/21CDEmH via IFTTT

Biochemical and morphological changes in rats exposed to platinum nanoparticles

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα

Abstract This study evaluated the toxicity potential of platinum (Pt) nanoparticles in Wistar rats. Wistar rats weighing between 180 and 193 g were randomly assigned into four groups. Animals in group 1 served as the control and received distilled water. Those in groups 2, 3, and 4 were administered with 10, 50, and 100 mg/kg body weight of Pt nanoparticles, respectively. At the end of treatments, the rats were fasted for 24 h and sacrificed under mild anesthesia. The blood and vital organs were collected and used for the biochemical and histopathological examinations. Pt nanoparti... περισσότερα »

Distal retinal ganglion cell axon transport loss and activation of p38 MAPK stress pathway following VEGF-A antagonism

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα

*Distal retinal ganglion cell axon transport loss and activation of p38 MAPK stress pathway following VEGF-A antagonism* Cell Death and Disease 7, e2212 (May 2016). doi:10.1038/cddis.2016.110 Authors: R Foxton, A Osborne, K R Martin, Y-S Ng & D T Shima from Cell via ola Kala on Inoreader http://ift.tt/1WdbMq7 via IFTTT

Marginal and apical bone stability after staged sinus floor augmentation using bone condensing implants with variable-thread design: a two-dimensional analysis

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 11 δευτερόλεπτα

[image: alertIcon.gif] Publication date: Available online 5 May 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): F. Younes, A. Eghbali, S. De Troyer, T. De Bruyckere, R. Cleymaet, J. Cosyn Studies on the vertical stability of augmented bone after sinus lifting differ substantially. In addition, long healing periods are usually advocated prior to implant installation. The purpose of this case series study was to evaluate the changes in bone height after sinus lifting with a bovine-derived xenograft and to evaluate the clinical outcome of bone condensin... περισσότερα »

Marginal and apical bone stability after staged sinus floor augmentation using bone condensing implants with variable-thread design: a two-dimensional analysis

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 11 δευτερόλεπτα

Impact of laparoscopic antireflux surgery on belching in pediatric GERD patients

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 12 δευτερόλεπτα

Abstract Background Laparoscopic antireflux surgery (LARS) is a well-established treatment option for children with proton pomp inhibitor (PPI)-resistant gastroesophageal reflux disease (GERD). Besides preventing reflux of gastric fluid and solid content, LARS may also impair the ability of the stomach to vent intragastric air (i.e. gastric belching) and induce gas-related complications, such as bloating and/or hyperflatulence. Furthermore, it was previously hypothesized that LARS induces a behavioral type of belching, not originating from the stomach, called supragastric belchin... περισσότερα »

The impact of abuse and mood on bowel symptoms and health-related quality of life in irritable bowel syndrome (IBS)

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 12 δευτερόλεπτα

Abstract Background Irritable bowel syndrome (IBS) is a common abdominal pain disorder without an organic explanation. Abuse histories (physical, sexual, emotional) are prevalent in IBS. While abuse relates to mood disorders (depression and anxiety) also common in IBS, the influence of abuse on gastrointestinal (GI) symptoms and health-related quality of life (HRQOL) and its independence from psychological symptom comorbidity has not been studied. Methods Consecutive GI outpatients completed the ROME III Research Diagnostic Questionnaire and questionnaires on trauma (Life-Stress ...περισσότερα »

Exploring a Phonological Process Approach to Adult Pronunciation Training

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 15 δευτερόλεπτα

Purpose The production of speech sound classes in adult language learners is affected by (a) interference between the native language and the target language and (b) speaker variables such as time speaking English. In this article, we demonstrate how phonological process analysis, an approach typically used in child speech, can be used to characterize adult target language phonological learning. Method Sentences produced by 2 adult Japanese English language learners were transcribed and coded for phoneme accuracy and analyzed according to the percent occurrence of phonological proce... περισσότερα »

Sonographic evaluation of lumbar interlaminar space opening in a variety of patient body positions for optimal neuraxial anesthesia delivery

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 20 δευτερόλεπτα

[image: gr1.sml] To find the position that provided the most comfort, as well as the widest L3-L4 interlaminar space opening. from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/21CDEmH via IFTTT

Marginal and apical bone stability after staged sinus floor augmentation using bone condensing implants with variable-thread design: a two-dimensional analysis

Publication date: Available online 5 May 2016 Source:International Journal of Oral and Maxillofacial Surgery Author(s): F. Younes, A. Eghbali, S. De Troyer, T. De Bruyckere, R. Cleymaet, J. Cosyn Studies on the vertical stability of augmented bone after sinus lifting differ substantially. In addition, long healing periods are usually advocated prior to implant installation. The […]

Family Matters: Promoting the Academic Adaptation of Latino Youth in New and Established Destination

As primary agents of socialization, families and schools can powerfully shape the academic adaptation of youth. Using data from the Social Identification and Academic Adaptation studies, we compare the family and school environments of Latino high school seniors living in a new destination, North Carolina, with those living in an established destination, Los Angeles. We […]

The Efficacy of Traditional Chinese Herbal Medicine in the Treatment of EGFR Mutated Stage IV Pulmonary Adenocarcinoma Patients Who Received First-Line EGFR-TKI Treatment

Background. Chinese herbal medicine (CHM) has been used for thousands of year in Eastern countries. First-line epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) treatment is the standard treatment in stage IV pulmonary adenocarcinoma patients who had tumor EGFR mutations. This study was to find the efficacy of CHM on lung cancer treatment. Materials and […]

Chrysin Increases the Therapeutic Efficacy of Docetaxel and Mitigates Docetaxel-Induced Edema

Docetaxel (DTX) is an effective commercial anticancer agent for chemotherapy in non–small cell lung cancer (NSCLC), breast cancer, gastric cancer, and prostate cancer, but its adverse effects including edema, neurotoxicity, and hair loss limit its application. To improve the chemotherapeutic efficacy of DTX and reduce adverse effects, combination therapy is one of the alternative methods. […]

In Vitro and In Vivo Efficacy Studies of Lavender angustifolia Essential Oil and Its Active Constituents on the Proliferation of Human Prostate Cancer

Exercise Training for Patients Pre- and Postsurgically Treated for Non-Small Cell Lung Cancer: A Systematic Review and Meta-analysis

Probiotic Survey in Cancer Patients Treated in the Outpatient Department in a Comprehensive Cancer Center

Synergistic Apoptotic Effect of D-Fraction From Grifola frondosa and Vitamin C on Hepatocellular Carcinoma SMMC-7721 Cells

Meta-Analysis of the Effects of Neuropsychological Interventions on Cognitive Function in Non-Central Nervous System Cancer Survivors

Survival Analysis of Advanced Non-Small Cell Lung Cancer Patients Treated by Using Wheel Balance Cancer Therapy

The Role of Emotion Regulation in Moral Judgment

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 25 δευτερόλεπτα

Abstract Moral judgment has typically been characterized as a conflict between emotion and reason. In recent years, a central concern has been determining which process is the chief contributor to moral behavior. While classic moral theorists claimed that moral evaluations stem from consciously controlled cognitive processes, recent research indicates that affective processes may be driving moral behavior. Here, we propose a new way of thinking about emotion within the context of moral judgment, one in which affect is generated and transformed by both automatic and controlled proc... περισσότερα »

Marginal and apical bone stability after staged sinus floor augmentation using bone condensing implants with variable-thread design: a two-dimensional analysis

sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 38 δευτερόλεπτα

Corticolimbic anatomical characteristics predetermine risk for chronic pain

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 41 δευτερόλεπτα

Mechanisms of chronic pain remain poorly understood. We tracked brain properties in subacute back pain patients longitudinally for 3 years as they either recovered from or transitioned to chronic pain. Whole-brain comparisons indicated corticolimbic, but not pain-related circuitry, white matter connections predisposed patients to chronic pain. Intra-corticolimbic white matter connectivity analysis identified three segregated communities: dorsal medial prefrontal cortex–amygdala–accumbens, ventral medial prefrontal cortex–amygdala, and orbitofrontal cortex–amygdala–hippocampus. Hig...περισσότερα »

Role of cortico-pallidal connectivity in the pathophysiology of dystonia

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 41 δευτερόλεπτα

from Neurology via xlomafota13 on Inoreader http://ift.tt/21CBjs6 via IFTTT

The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 41 δευτερόλεπτα

Functional imaging using positron emission tomography and later functional magnetic resonance imaging revealed a particular brainstem area that is believed to be specifically activated in migraine during, but not outside of the attack, and consequently has been coined the 'migraine generator'*.* However, the pathophysiological concept behind this term is not undisputed and typical migraine premonitory symptoms such as fatigue and yawning, but also a typical association of attacks to circadian and menstrual cycles, all make the hypothalamus a possible regulating region of migraine a...περισσότερα »

Reply: Role of cortico-pallidal connectivity in the pathophysiology of dystonia

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 41 δευτερόλεπτα

from Neurology via xlomafota13 on Inoreader http://ift.tt/21CBjbs via IFTTT

CSF1R mosaicism in a family with hereditary diffuse leukoencephalopathy with spheroids

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 41 δευτερόλεπτα

Mutations in the colony stimulating factor 1 receptor (*CSF1R)* have recently been discovered as causal for hereditary diffuse leukoencephalopathy with axonal spheroids. We identified a novel, heterozygous missense mutation in *CSF1R* [c.1990G > A p.(E664K)] by exome sequencing in five members of a family with hereditary diffuse leukoencephalopathy with axonal spheroids. Three affected siblings had characteristic white matter abnormalities and presented with progressive neurological decline. In the fourth affected sibling, early progression halted after allogeneic haematopoietic s... περισσότερα »

In vivo imaging of neuromelanin in Parkinsons disease using 18F-AV-1451 PET

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 41 δευτερόλεπτα

The tau tangle ligand 18F-AV-1451 (18F-T807) binds to neuromelanin in the midbrain, and may therefore be a measure of the pigmented dopaminergic neuronal count in the substantia nigra. Parkinson's disease is characterized by progressive loss of dopaminergic neurons. Extrapolation of post-mortem data predicts that a ~30% decline of nigral dopamine neurons is necessary to cause motor symptoms in Parkinson's disease. Putamen dopamine terminal loss at disease onset most likely exceeds that of the nigral cell bodies and has been estimated to be of the order of 50–70%. We investigated t...περισσότερα »

Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα

*Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis* Cell Death and Disease 7, e2214 (May 2016). doi:10.1038/cddis.2016.107 Authors: S Neitemeier, A M Dolga, B Honrath, S S Karuppagounder, I Alim, R R Ratan & C Culmsee from Cell via ola Kala on Inoreader http://ift.tt/1T1P6Fe via IFTTT

Transcription factor Six2 mediates the protection of GDNF on 6-OHDA lesioned dopaminergic neurons by regulating Smurf1 expression

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα

*Transcription factor Six2 mediates the protection of GDNF on 6-OHDA lesioned dopaminergic neurons by regulating Smurf1 expression* Cell Death and Disease 7, e2217 (May 2016). doi:10.1038/cddis.2016.120 Authors: J Gao, X-y Kang, S Sun, L Li, B-l Zhang, Y-q Li & D-s Gao from Cell via ola Kala on Inoreader http://ift.tt/1WdbJum via IFTTT

PXR interaction with p53: a meeting of two masters

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα

*PXR interaction with p53: a meeting of two masters* Cell Death and Disease 7, e2218 (May 2016). doi:10.1038/cddis.2016.122 Authors: D Robbins, J Bakke, M T Cherian, J Wu & T Chen from Cell via ola Kala on Inoreader http://ift.tt/1T1P6F6 via IFTTT

SP6616 as a new Kv2.1 channel inhibitor efficiently promotes β-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα

*SP6616 as a new Kv2.1 channel inhibitor efficiently promotes β-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways* Cell Death and Disease 7, e2216 (May 2016). doi:10.1038/cddis.2016.119 Authors: T T Zhou, L L Quan, L P Chen, T Du, K X Sun, J C Zhang, L Yu, Y Li, P Wan, L L Chen, B H Jiang, L H Hu, J Chen & X Shen from Cell via ola Kala on Inoreader http://ift.tt/1WdbJug via IFTTT

Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα

*Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses* Cell Death and Disease 7, e2215 (May 2016). doi:10.1038/cddis.2016.113 Authors: P Cunin, C Beauvillain, C Miot, J-F Augusto, L Preisser, S Blanchard, P Pignon, M Scotet, E Garo, I Fremaux, A Chevailler, J-F Subra, P Blanco, M R Wilson, P Jeannin & Y Delneste from Cell via ola Kala on Inoreader http://ift.tt/1WdbM9F via IFTTT

The CS Sulfation Motifs 4C3, 7D4, 3B3[−]; and Perlecan Identify Stem Cell Populations and Their Niches, Activated Progenitor Cells and Transitional Areas of Tissue Development in the Fetal Human Elbow

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα

Stem Cells and Development , Vol. 0, No. 0. from Cell via ola Kala on Inoreader http://ift.tt/24wfaRl via IFTTT

Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα

*Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma* Cell Death and Disease 7, e2213 (May 2016). doi:10.1038/cddis.2016.117 Authors: F Ahmad, D Dixit, V Sharma, A Kumar, S D Joshi, C Sarkar & E Sen from Cell via ola Kala on Inoreader http://ift.tt/1T1P6EY via IFTTT

Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα

*Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer* Cell Death and Disease 7, e2211 (May 2016). doi:10.1038/cddis.2016.114 Authors: T Taniguchi, Y Iizumi, M Watanabe, M Masuda, M Morita, Y Aono, S Toriyama, M Oishi, W Goi & T Sakai from Cell via ola Kala on Inoreader http://ift.tt/1T1P6oI via IFTTT

Exploring a Phonological Process Approach to Adult Pronunciation Training

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 44 δευτερόλεπτα

KE108-conjugated unimolecular micelles loaded with a novel HDAC inhibitor thailandepsin-A for targeted neuroendocrine cancer therapy

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 48 δευτερόλεπτα

[image: alertIcon.gif] Publication date: August 2016 *Source:*Biomaterials, Volume 97 Author(s): Guojun Chen, Renata Jaskula–Sztul, April Harrison, Ajitha Dammalapati, Wenjin Xu, Yiqiang Cheng, Herbert Chen, Shaoqin Gong Neuroendocrine (NE) cancers can cause significant patient morbidity. Besides surgery, there are no curative treatments for NE cancers and their metastases, emphasizing the need for the development of other forms of therapy. In this study, multifunctional unimolecular micelles were developed for targeted NE cancer therapy. The unimolecular micelles were formed by mul...περισσότερα »

Future of nanotherapeutics: Targeting the cellular sub-organelles

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 48 δευτερόλεπτα

[image: S01429612.gif] Publication date: August 2016 *Source:*Biomaterials, Volume 97 Author(s): Xiaowei Ma, Ningqiang Gong, Lin Zhong, Jiadong Sun, Xing-Jie Liang Many diseases originate from alterations at nanoscale levels. Precise drug delivery should be achieved not only at cell level, but also at organelle level to achieve maximum therapeutic responses as well as avoiding possible toxic side effects of the drugs. However, organelles and subcellular structures are natural barriers that hampering many therapeutics from taking effects. Nanodelivery vehicle is a favorable platform ... περισσότερα »

Long-term treatment with aldosterone slows the progression of age-related hearing loss

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα

[image: S03785955.gif] Publication date: Available online 5 May 2016 *Source:*Hearing Research Author(s): Joshua Halonen, Ashley Hinton, Robert D. Frisina, Bo Ding, Xiaoxia Zhu, Joseph P. Walton Age-related hearing loss (ARHL), clinically referred to as presbycusis, is one of the three most prevalent chronic medical conditions of our elderly, with the majority of persons over the age of 60 suffering from some degree of ARHL. The progressive loss of auditory sensitivity and perceptual capability results in significant declines in workplace productivity, quality of life, cognition and... περισσότερα »

Time dependent structure of postural sway in individuals with multiple sclerosis

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα

Publication date: July 2016 *Source:*Gait & Posture, Volume 48 Author(s): Kathleen L. Roeing, Douglas A. Wajda, Jacob J. Sosnoff Non-linear analyses, which examine the time dependent structure of physiological output have been found to be able to detect subtle differences in postural control between pathological groups and healthy controls while traditional linear parameters do not. This investigation examines whether a specific non-linear metric, approximate entropy, may provide a novel biomarker for balance impairment in individuals with multiple sclerosis (MS) who have normal sway....περισσότερα »

Effects of running-induced fatigue on plantar pressure distribution in novice runners with different foot types

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα

Publication date: Available online 5 May 2016 *Source:*Gait & Posture Author(s): Mehrdad Anbarian, Hamed Esmaili This study aimed to assess the effects of running-induced fatigue on plantar pressure parameters in novice runners with low and high medial longitudinal arch. Plantar pressure data from 42 novice runners (21 with high, and 21 with low arch) were collected before and after running-induced fatigue protocol during running at 3.3m/s along the Footscan® platform. Peak plantar pressure, peak force and force-time integral (impulse) were measured in ten anatomical zones. Relative t...περισσότερα »

Buried territories: heterochromatic response to DNA double-strand breaks

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 1 ώρα

Cellular response to DNA double-strand breaks (DSBs), the most deleterious type of DNA damage, is highly influenced by higher-order chromatin structure in eukaryotic cells. Compared with euchromatin, the compacted structure of heterochromatin not only protects heterochromatic DNA from damage, but also adds an extra layer of control over the response to DSBs occurring in heterochromatin. One key step in this response is the decondensation of heterochromatin structure. This decondensation process facilitates the DNA damage signaling and promotes proper heterochromatic DSB repair, th... περισσότερα »