Head and Neck Medicine by Alexandros G.Sfakianakis: OtoRhinoLaryngology & Medicine,New Articles,May 5th,2016,a

Πέμπτη 5 Μαΐου 2016

OtoRhinoLaryngology & Medicine,New Articles,May 5th,2016,a

Eosinophilic oesophagitis: a systematic review for otolaryngologists.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 λεπτό

Related Articles *Eosinophilic oesophagitis: a systematic review for otolaryngologists.* J Laryngol Otol. 2015 Dec;129(12):1156-66 Authors: Bahgat M, Dawe N, Flood L Abstract BACKGROUND: Eosinophilic oesophagitis is a chronic, immune/antigen-mediated oesophageal disease, only recently, but increasingly, recognised in the world literature. It is diagnosed and managed primarily by medical gastroenterologists and allergy specialists, and is a distinct disease entity, affecting both children and adults. Few studies have been published in otolaryngology journals, although otolaryngolo...περισσότερα »

Prevalence and Overlap of Noncardiac Conditions in the Evaluation of Low-risk Acute Chest Pain Patients.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 λεπτό

[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Prevalence and Overlap of Noncardiac Conditions in the Evaluation of Low-risk Acute Chest Pain Patients.* Crit Pathw Cardiol. 2015 Sep;14(3):97-102 Authors: Al-Ani M, Winchester DE Abstract BACKGROUND: When patients present to the emergency department with a complaint concerning for heart disease, this often becomes the primary focus of their evaluation. While patients with noncardiac causes of chest pain outnumber those with cardiac causes, noncardiac etiologies are frequently overlooked. We investigated symptom... περισσότερα »

Derivation and Internal Validation of the Ebola Prediction Score for Risk Stratification of Patients With Suspected Ebola Virus Disease.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 λεπτό

[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Derivation and Internal Validation of the Ebola Prediction Score for Risk Stratification of Patients With Suspected Ebola Virus Disease.* Ann Emerg Med. 2015 Sep;66(3):285-293.e1 Authors: Levine AC, Shetty PP, Burbach R, Cheemalapati S, Glavis-Bloom J, Wiskel T, Kesselly JK Abstract STUDY OBJECTIVE: The current outbreak of Ebola virus disease in West Africa is the largest on record and has overwhelmed the capacity of local health systems and the international community to provide sufficient isolation and treatmen... περισσότερα »

QoS and QoE Aware N-Screen Multicast Service

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα

The paper focuses on ensuring the quality-of-service (QoS) and quality-of-experience (QoE) requirements of users having heterogeneous devices in a multicast session. QoS parameters such as bit rate, delays, and packet losses are good indicators for optimizing network services but fall short in characterizing user perception (QoE). In N-Screen service, the users have different devices with […]

Aggressive Angiomyxoma in Pregnancy: A Rare Condition, a Common Misdiagnosis

Introduction. Aggressive angiomyxoma is a rare mesenchymal neoplasm. Although benign in the majority of the cases, these neoplasms usually present a locally infiltrative nature and high rates of recurrence. Due to its rarity, misdiagnosis is a common problem. Case Presentation. We present one case of aggressive angiomyxoma in a 25-year-old pregnant woman. The patient presented […]

Within-Host Heterogeneity of Mycobacterium tuberculosis Infection Is Associated With Poor Early Treatment Response: A Prospective Cohort Study

The clinical management of tuberculosis is a major challenge in southern Africa. The prevalence of within-host genetically heterogeneous Mycobacterium tuberculosis infection and its effect on treatment response are not well understood. We enrolled 500 patients with tuberculosis in KwaZulu-Natal and followed them through 2 months of treatment. Using mycobacterial interspersed repetitive units–variable number of tandem […]

Mannose Receptor Is Required for Optimal Induction of Vaccine-Induced T-Helper Type 17 Cells and Resistance to Blastomyces dermatitidis Infection

We investigated how innate sensing by the mannose receptor (MR) influences the development of antifungal immunity. We demonstrate that MR senses mannan on the surface of attenuated Blastomyces dermatitidis vaccine yeast and that MR–/– mice demonstrate impaired vaccine immunity against lethal experimental blastomycosis, compared with wild-type control mice. Using naive Blastomyces-specific transgenic CD4+ T cells, […]

Correlation Between Meis1 and Msi1 in Esophageal Squamous Cell Carcinoma

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 8 δευτερόλεπτα

Correlation Between Meis1 and Msi1 in Esophageal Squamous Cell Carcinoma: Abstract PurposeHomeobox (HOX) transcription factors are critical regulators of cell fate, stem cell functions, and gastrointestinal development. They require three-amino acid loop extension (TALE) homeodomain proteins such as Meis1 to enhance their transcriptional efficiencies. There are complicated associations between different signaling pathways such as the Wnt and NOTCH and tumor progression. It has been investigated that GSK-3 as an important component of the Wnt pathway facilitates the expression of HO... περισσότερα »

Plasma phospholipids fatty acids, dietary fatty acids, and breast cancer risk

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 8 δευτερόλεπτα

Plasma phospholipids fatty acids, dietary fatty acids, and breast cancer risk: Abstract PurposeThis study prospectively investigates associations between fatty acids assessed in plasma phospholipids (PPL) and diet, and breast cancer risk, including subgroups defined by hormone receptor status. MethodsWe performed a case-cohort analysis within the Melbourne Collaborative Cohort Study using a random sample of 2,021 women and 470 breast cancer cases. At baseline, fatty acids were assessed in PPL and estimated from diet using a 121-item food frequency questionnaire. Hazard ratios ...περισσότερα »

Functional Esophageal Disorders.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 8 δευτερόλεπτα

*Functional Esophageal Disorders.* Gastroenterology. 2016 Feb 15; Authors: Aziz Q, Fass R, Gyawali CP, Miwa H, Pandolfino JE, Zerbib F Abstract Functional esophageal disorders consist of a disease category that present with esophageal symptoms (heartburn, chest pain, dysphagia, globus) not explained by mechanical obstruction (stricture, tumor, eosinophilic esophagitis), major motor disorders (achalasia, EGJ outflow obstruction, absent contractility, distal esophageal spasm, jackhammer esophagus), or gastroesophageal reflux disease (GERD). While mechanisms responsible are unclear,... περισσότερα »

Botulinum Toxin in Secondarily Nonresponsive Patients with Spasmodic Dysphonia.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 8 δευτερόλεπτα

*Botulinum Toxin in Secondarily Nonresponsive Patients with Spasmodic Dysphonia.* Otolaryngol Head Neck Surg. 2016 May 3; Authors: Mor N, Tang C, Blitzer A Abstract Chemodenervation with botulinum toxin (BoNT) has been effective and well tolerated for all types of dystonia for >30 years. We reviewed outcomes of our patients treated with BoNT serotype A (BoNT-A) for spasmodic dysphonia (SD) who became secondarily nonresponsive. We found that 8 of 1400 patients became nonresponsive to BoNT-A (0.57%), which is lower than the secondary nonresponse rate in other dystonias. After a ces...περισσότερα »

Predictors for Permanent Medialization Laryngoplasty in Unilateral Vocal Fold Paralysis.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 8 δευτερόλεπτα

*Predictors for Permanent Medialization Laryngoplasty in Unilateral Vocal Fold Paralysis.* Otolaryngol Head Neck Surg. 2016 May 3; Authors: Mor N, Wu G, Aylward A, Christos PJ, Sulica L Abstract OBJECTIVE: Early differentiation of patients with unilateral vocal fold paralysis (VFP) who recover from those who do not and consequently require permanent medialization laryngoplasty (ML) remains a challenge. The goal of this study is to identify factors that predict the need for ML. STUDY DESIGN: Case series with chart review. SETTING: Academic center. SUBJECTS AND METHODS: A total of 50... περισσότερα »

Impaired Esophageal Mucosal Integrity May Play a Causative Role in Patients With Nongastroesophageal Reflux Disease-Related Noncardiac Chest Pain.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 8 δευτερόλεπτα

[image: http:--pt.wkhealth.com-pt-pt-core-templa] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Impaired Esophageal Mucosal Integrity May Play a Causative Role in Patients With Nongastroesophageal Reflux Disease-Related Noncardiac Chest Pain.* Medicine (Baltimore). 2015 Dec;94(51):e2295 Authors: Min YW, Choi K, Pyo JH, Son HJ, Rhee PL Abstract Baseline impedance (BI) measurement can be used to evaluate the status of the esophageal mucosa integrity. We hypothesized that impaired esophageal mucosal integrity may play a causative role in patients with nongastroesophageal ... περισσότερα »

[Clinical analysis of 163 patients with remnant gastric cancer].

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 8 δευτερόλεπτα

Related Articles *[Clinical analysis of 163 patients with remnant gastric cancer].* Zhonghua Wei Chang Wai Ke Za Zhi. 2015 Dec;18(12):1253-5 Authors: Xiao Y, Chen L Abstract OBJECTIVE: To discuss the clinical characteristics of remnant gastric cancer (RGC). METHODS: Clinical data of 163 patients with RGC admitted to our department from January 2005 to January 2015 were collected and reviewed. RESULTS: The time duration of all the RGC patients between primary gastrectomy and occurrence of RGC ranged from 9 to 46 years (median 27.5 years). Among 163 patients, 112(68.7%) patients man...περισσότερα »

Prevalence and Overlap of Noncardiac Conditions in the Evaluation of Low-risk Acute Chest Pain Patients.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 9 δευτερόλεπτα

Derivation and Internal Validation of the Ebola Prediction Score for Risk Stratification of Patients With Suspected Ebola Virus Disease.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 9 δευτερόλεπτα

Surgical correction of septal deviation after Le Fort I osteotomy

Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 9 δευτερόλεπτα

Abstract Background The Le Fort I osteotomy is one of the most widely used and useful procedure to correct the dentofacial deformities of the midface. The changes of the maxilla position affect to overlying soft tissue including the nasal structure. Postoperative nasal septum deviation is a rare and unpredicted outcome after the surgery. There are only a few reports reporting the management of this complication. Case Presentation In our department, three cases of the postoperative nasal septum deviation after the Le Fort I osteotomy had been experienced. Via limited intraoral cir... περισσότερα »

[Laparoscopic fundoplication for gastroesophageal reflux disease-related cough: a report of 70 cases].

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 17 δευτερόλεπτα

Related Articles *[Laparoscopic fundoplication for gastroesophageal reflux disease-related cough: a report of 70 cases].* Zhonghua Wei Chang Wai Ke Za Zhi. 2015 Dec;18(12):1244-7 Authors: Hu Z, Wu J, Liang W, Yan C, Wang Z Abstract OBJECTIVE: To investigate the efficacy and safety of laparoscopic fundoplication for gastroesophageal reflux disease (GERD)-related cough. METHODS: Retrospective review of 70 patients with GERD-related cough who received laparoscopic fundoplication in GERD Department of The Second Artillery General Hospital during June 2008 to June 2013 was carried out.... περισσότερα »

Eosinophilic oesophagitis: a systematic review for otolaryngologists.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 17 δευτερόλεπτα

Prevalence and Overlap of Noncardiac Conditions in the Evaluation of Low-risk Acute Chest Pain Patients.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 17 δευτερόλεπτα

Derivation and Internal Validation of the Ebola Prediction Score for Risk Stratification of Patients With Suspected Ebola Virus Disease.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 17 δευτερόλεπτα

Neuromuscular electrical stimulation improves radiation-induced fibrosis through Tgf-Β1/MyoD homeostasis in head and neck cancer.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 17 δευτερόλεπτα

*Neuromuscular electrical stimulation improves radiation-induced fibrosis through Tgf-Β1/MyoD homeostasis in head and neck cancer.* J Surg Oncol. 2016 May 4; Authors: Peng G, Masood K, Gantz O, Sinha U Abstract OBJECTIVES: The purpose of this study was to analyze TGF-β1 and MyoD expression in cervical muscles during radiation therapy (RT) and their role in inducing muscle fibrosis in head and neck cancer (HNC) patients. We also studied the effect of combined traditional swallow therapy (TST) and neuromuscular electrical stimulation (NMES) therapy on TGF-β1/MyoD homeostasis in pat... περισσότερα »

Functional Esophageal Disorders.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 17 δευτερόλεπτα

Looking into oropharyngeal dysphagia in older adults.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 17 δευτερόλεπτα

*Looking into oropharyngeal dysphagia in older adults.* Nursing. 2016 May 3; Authors: Canham M PMID: 27144326 [PubMed - as supplied by publisher] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/24tuE8A via IFTTT

Endoscopic and Abdominal Management of Complete Benign Esophageal Obstruction.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 17 δευτερόλεπτα

*Endoscopic and Abdominal Management of Complete Benign Esophageal Obstruction.* ACG Case Rep J. 2016 Apr;3(3):162-4 Authors: Al-Lehibi A Abstract Benign esophageal strictures leading to complete esophageal occlusion are well known. In the pre-endoscopic era, such cases required surgery, but over the last decade, various novel endoscopic techniques have been developed to prevent morbidity and mortality. A 37-year-old man presented after 1 year of dysphagia and weight loss, and was found to have complete esophageal obstruction, not allowing even passage of guidewire. We used a co... περισσότερα »

Videofluoroscopic Swallow Examination Does Not Accurately Detect Cricopharyngeal Radiation Strictures.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 17 δευτερόλεπτα

*Videofluoroscopic Swallow Examination Does Not Accurately Detect Cricopharyngeal Radiation Strictures.* Otolaryngol Head Neck Surg. 2016 May 3; Authors: Szczesniak MM, Maclean J, O'Hare J, Humbert I, Wu PI, Quon H, Graham PH, Cook IJ Abstract Videofluoroscopy is the standard technique to evaluate dysphagia following radiotherapy for head and neck cancer (HNC). The accuracy of radiography in detecting strictures at the pharyngoesophageal junction is unknown. Our aim was to determine the diagnostic accuracy of videofluoroscopy in detecting strictures at the pharyngoesophageal junc...περισσότερα »

[The clinical, radiological and prognostic factor analysis of medullary infarction].

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 17 δευτερόλεπτα

*[The clinical, radiological and prognostic factor analysis of medullary infarction].* Zhonghua Nei Ke Za Zhi. 2016 May 1;55(5):361-5 Authors: Sun AP, Liu XY, Sun QL, Chen L, Liu XL, Fan DS Abstract OBJECTIVE: To investigate the clinical and radiological features of medullary infarction (MI), and to compare the clinical characteristics of lateral medullary infarction (LMI) and medial medullary infarction (MMI). METHODS: Patients diagnosed as acute MI who were treated from January 2009 to December 2014 in Department of Neurology, Peking University Third Hospital, were retrospective...περισσότερα »

Clinical and neuroradiological features of spinocerebellar ataxia 38 (SCA38).

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 17 δευτερόλεπτα

*Clinical and neuroradiological features of spinocerebellar ataxia 38 (SCA38).* Parkinsonism Relat Disord. 2016 Apr 27; Authors: Borroni B, Di Gregorio E, Orsi L, Vaula G, Costanzi C, Tempia F, Mitro N, Caruso D, Manes M, Pinessi L, Padovani A, Brusco A, Boccone L Abstract INTRODUCTION: SCA38 (MIM 611805) caused by mutations within the ELOVL5 gene, which encodes an enzyme involved in the synthesis of long-chain fatty acids with a high and specific expression in Purkinje cells, has recently been identified. OBJECTIVE: The present study was aimed at describing the clinical and neur... περισσότερα »

Impaired Esophageal Mucosal Integrity May Play a Causative Role in Patients With Nongastroesophageal Reflux Disease-Related Noncardiac Chest Pain.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 17 δευτερόλεπτα

[Clinical analysis of 163 patients with remnant gastric cancer].

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 17 δευτερόλεπτα

The Effects of Odor Quality and Temporal Asynchrony on Modulation of Taste Intensity by Retronasal Odor.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

*The Effects of Odor Quality and Temporal Asynchrony on Modulation of Taste Intensity by Retronasal Odor.* Chem Senses. 2016 May 3; Authors: Isogai T, Wise PM Abstract The experiments had 2 main goals: 1) to add to the sparse literature on how retronasal aromas interact with bitter tastes, and 2) to determine whether modulation of taste intensity by aroma depends on temporal contiguity, as one might expect if flavor interactions depend on cross-modal binding (similar to object perception in other modalities). An olfactometer-gustometer allowed independent oral presentation of odo...περισσότερα »

Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

[image: http:--highwire.stanford.edu-icons-exter] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components.* Innate Immun. 2014 Aug;20(6):606-17 Authors: Lee RJ, Chen B, Redding KM, Margolskee RF, Cohen NA Abstract We previously observed that the human bitter taste receptor T2R38 is an important component of upper respiratory innate defense because it detects acyl homoserine lactone (AHL) quorum-sensing molecules secreted by Gram-negative bacteria. T2... περισσότερα »

Development and Application of Syndromic Surveillance for Severe Weather Events Following Hurricane Sandy

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα

Research Articles Stella Tsai, Teresa Hamby, Alvin Chu, Jessie A. Gleason, Gabrielle M. Goodrow, Hui Gu, Edward Lifshitz, Jerald A. Fagliano Disaster Medicine and Public Health Preparedness,FirstView Article(s), 9 pages Abstract from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Zhdl3C via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Within-Host Heterogeneity of Mycobacterium tuberculosis Infection Is Associated With Poor Early Treatment Response: A Prospective Cohort Study

Mannose Receptor Is Required for Optimal Induction of Vaccine-Induced T-Helper Type 17 Cells and Resistance to Blastomyces dermatitidis Infection

Histological Evidence of Chronic Mycoplasma genitalium-Induced Cervicitis in HIV-Infected Women: A Retrospective Cohort Study

Background. Mycoplasma genitalium is an emerging sexually transmitted pathogen implicated in inflammatory syndromes of the female reproductive tract. The objective of this study was to investigate human immunodeficiency virus (HIV)–infected women for an association between M. genitalium and cervicitis, a putative mechanism for enhanced HIV transmission efficiency to an uninfected partner. Methods. Using a longitudinal […]

Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01

Background. Models of controlled human malaria infection (CHMI) initiated by mosquito bite have been widely used to assess efficacy of preerythrocytic vaccine candidates in small proof-of-concept phase 2a clinical trials. Efficacy testing of blood-stage malaria parasite vaccines, however, has generally relied on larger-scale phase 2b field trials in malaria-endemic populations. We report the use of […]

Permanently Porous Single Molecule H-Bonded Organic Framework for Selective CO2 Capture

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 32 δευτερόλεπτα

*Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC02964G, Communication Shyamapada Nandi, Debanjan Chakraborty, Vaidhyanathan Ramanathan Permanant porosity has been realized in a hydrogen bonded framework formed by a single tripodal tricarboxylic acid molecule. The presence of three phenyl rings linked to a flexible *sp3* nitrogen... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1ZhaKGQ via IFTTT

Genomic Analysis of Serogroup Y Neisseria meningitidis Isolates Reveals Extensive Similarities Between Carriage-Associated and Disease-Associated Organisms

sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα

Background. Neisseria meningitidis is a frequent colonizer of the human nasopharynx, with asymptomatic carriage providing the reservoir for invasive, disease-causing strains. Serogroup Y (MenY) strains are a major cause of meningococcal disease. High-resolution genetic analyses of carriage and disease isolates can establish epidemiological relationships and identify potential virulence factors. Methods. Whole-genome sequence data were obtained […]

Oral Typhoid Vaccination With Live-Attenuated Salmonella Typhi Strain Ty21a Generates Ty21a-Responsive and Heterologous Influenza Virus-Responsive CD4+ and CD8+ T Cells at the Human Intestinal Mucosa

Background. Oral vaccination with live-attenuated Salmonella Typhi strain Ty21a is modestly efficacious, but the mechanisms of protection are currently unknown. While humoral and cellular immune responses are well described in peripheral blood, the cellular response at the intestinal mucosa has never been directly assessed. Methods. We vaccinated healthy adults with Ty21a and assessed humoral and […]

Can Changes to Scheduling Enhance the Performance of Rotavirus Vaccines in Low-Income Countries?

from Infectious Diseases via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24tASVZ via IFTTT

Dietary Lipid Type, Rather Than Total Number of Calories, Alters Outcomes of Enteric Infection in Mice

Dietary lipids modulate immunity, yet the means by which specific fatty acids affect infectious disease susceptibility remains unclear. Deciphering lipid-induced immunity is critical to understanding the balance required for protecting against pathogens while avoiding chronic inflammatory diseases. To understand how specific lipids alter susceptibility to enteric infection, we fed mice isocaloric, high-fat diets composed of […]

Maintaining a Safe Blood Supply in an Era of Emerging Pathogens

Coming shortly after outbreaks of dengue and chikungunya virus in related locations, the recent outbreak of Zika virus in the southern part of the western hemisphere is yet another reminder that infectious pathogens continue to emerge rapidly and can adversely affect public health, including the safety of the blood supply. In response to Zika virus, […]

Vaccination Against Hepatitis B Virus (HBV) in HIV-1-Infected Patients With Isolated Anti-HBV Core Antibody: The ANRS HB EP03 CISOVAC Prospective Study

Background. Although an isolated anti–hepatitis B virus (HBV) core antibody (anti-HBc) serological profile is frequent in human immunodeficiency virus (HIV)–infected patients, data on HBV vaccination in these patients are scarce. Methods. A prospective multicenter study was conducted to assess the immunogenicity of HBV vaccination in 54 patients with an isolated anti-HBc profile and undetectable HIV […]

A Randomized, Controlled Trial of the Impact of Alternative Dosing Schedules on the Immune Response to Human Rotavirus Vaccine in Rural Ghanaian Infants

Background. The recommended schedule for receipt of 2-dose human rotavirus vaccine (HRV) coincides with receipt of the first and second doses of diphtheria, pertussis, and tetanus vaccine (ie, 6 and 10 weeks of age, respectively). Alternative schedules and additional doses of HRV have been proposed and may improve vaccine performance in low-income countries. Methods. In […]

New Insights Into the Transmissibility of Leishmania infantum From Dogs to Sand Flies: Experimental Vector-Transmission Reveals Persistent Parasite Depots at Bite Sites

Canine leishmaniasis (CanL) is a chronic fatal disease of dogs and a major source of human infection through propagation of parasites in vectors. Here, we infected 8 beagles through multiple experimental vector transmissions with Leishmania infantum–infected Lutzomyia longipalpis. CanL clinical signs varied, although live parasites were recovered from all dog spleens. Splenic parasite burdens correlated […]

Maintaining a Safe Blood Supply in an Era of Emerging Pathogens

Vaccination Against Hepatitis B Virus (HBV) in HIV-1-Infected Patients With Isolated Anti-HBV Core Antibody: The ANRS HB EP03 CISOVAC Prospective Study

A Randomized, Controlled Trial of the Impact of Alternative Dosing Schedules on the Immune Response to Human Rotavirus Vaccine in Rural Ghanaian Infants

New Insights Into the Transmissibility of Leishmania infantum From Dogs to Sand Flies: Experimental Vector-Transmission Reveals Persistent Parasite Depots at Bite Sites

Noninterference of Rotavirus Vaccine With Measles-Rubella Vaccine at 9 Months of Age and Improvements in Antirotavirus Immunity: A Randomized Trial

Background. The burden of rotavirus morbidity and mortality is high in children aged <5 years in developing countries, and evaluations indicate waning protection from rotavirus immunization in the second year. An additional dose of rotavirus vaccine may enhance the immune response and lengthen the period of protection against disease, but coadministration of this dose should […]

Helicobacter pylori Activates Matrix Metalloproteinase 10 in Gastric Epithelial Cells via EGFR and ERK-mediated Pathways

Helicobacter pylori colonizes the human stomach and increases the risk for peptic ulcer disease and gastric carcinoma. H. pylori upregulates the expression and activity of several matrix metalloproteinases (MMPs) in cell lines and in the gastric mucosa. The aim of this study was to explore the mechanisms leading to upregulation of MMP10 in gastric epithelial […]

Clinical and Quality of Life Outcomes of Speech Treatment for Parkinson's Disease Delivered to the Home Via Telerehabilitation: A Noninferiority Randomized Controlled Trial.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 38 δευτερόλεπτα

*Clinical and Quality of Life Outcomes of Speech Treatment for Parkinson's Disease Delivered to the Home Via Telerehabilitation: A Noninferiority Randomized Controlled Trial.* Am J Speech Lang Pathol. 2016 May 4;:1-19 Authors: Theodoros DG, Hill AJ, Russell TG Abstract Purpose: This study investigated the noninferiority and validity of an intensive speech treatment for people with Parkinson's disease (PD) delivered via telerehabilitation to the home. The effect of location on online delivery was also investigated. Method: In this single-blinded, randomized controlled noninferiorit... περισσότερα »

Is India's policy framework geared for effective action on avoidable blindness from diabetes?

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 38 δευτερόλεπτα

*Is India's policy framework geared for effective action on avoidable blindness from diabetes?* Indian J Endocrinol Metab. 2016 Apr;20(Suppl 1):S42-50 Authors: Gaiha SM, Shukla R, Gilbert CE, Anchala R, Gudlavalleti MV Abstract BACKGROUND: The growing burden of avoidable blindness caused by diabetic retinopathy (DR) needs an effective and holistic policy that reflects mechanisms for early detection and treatment of DR to reduce the risk of blindness. MATERIALS AND METHODS: We performed a comprehensive health policy review to highlight the existing systemic issues that enable polic... περισσότερα »

Botulinum Toxin in Secondarily Nonresponsive Patients with Spasmodic Dysphonia.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 38 δευτερόλεπτα

Predictors for Permanent Medialization Laryngoplasty in Unilateral Vocal Fold Paralysis.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 38 δευτερόλεπτα

Semantic language models with deep neural networks

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 38 δευτερόλεπτα

[image: S08852308.gif] Publication date: Available online 4 May 2016 *Source:*Computer Speech & Language Author(s): Ali Orkan Bayer, Giuseppe Riccardi In this paper we explore the use of semantics in training language models for automatic speech recognition and spoken language understanding. Traditional language models (LMs) do not consider the semantic constraints and train models based on fixed-sized word histories. The theory of frame semantics analyzes word meanings and their constructs by using “semantic frames”. Semantic frames represent a linguistic scene with its relevant pa... περισσότερα »

Modulation of the wettability of excipients by surfactant and its impacts on the disintegration and release of tablets.

Alexandros G. SfakianakisστοHead and NeckΠριν από 39 δευτερόλεπτα

*Modulation of the wettability of excipients by surfactant and its impacts on the disintegration and release of tablets.* Drug Dev Ind Pharm. 2016 May 4;:1-39 Authors: Yang B, Xu L, Wang Q, Li S Abstract OBJECTIVE: To investigate the modulation of the wettability of excipients by types of surfactants and its impacts on the disintegration of tablets and drug release. MATERIALS AND METHODS: The critical micelle concentration (CMC) of surfactants including sodium dodecyl sulfate (SDS), sodium dodecyl benzene sulfonate (SDBS), dodecyl trimethyl ammonium bromide (DTAB), cetyltrimethyl ...περισσότερα »

RGD peptide targeted lipid coated nanoparticles for combinatorial delivery of sorafenib and quercetin against hepatocellular carcinoma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 39 δευτερόλεπτα

*RGD peptide targeted lipid coated nanoparticles for combinatorial delivery of sorafenib and quercetin against hepatocellular carcinoma.* Drug Dev Ind Pharm. 2016 May 4;:1-29 Authors: Wang C, Su L, Wu C, Wu J, Zhu C, Yuan G Abstract CONTEXT: Combination therapies provide a potential solution to addressing the tumor heterogeneity and drug resistance issues by taking advantage of distinct mechanisms of action of the multiple therapeutics. OBJECTIVE: To design arginine-glycineaspartic acid (RGD) modified lipid coated nanoparticles (NPs) for the co-delivery of the hydrophobic drugs ag...περισσότερα »

Efficacy and safety of pharmacological agents in the treatment of erythema migrans in early Lyme borreliosis-systematic review protocol.

Alexandros G. SfakianakisστοHead and NeckΠριν από 39 δευτερόλεπτα

*Efficacy and safety of pharmacological agents in the treatment of erythema migrans in early Lyme borreliosis-systematic review protocol.* Syst Rev. 2016;5(1):73 Authors: Torbahn G, Hofmann H, Allert R, Freitag MH, Dersch R, Fingerle V, Sommer H, Motschall E, Meerpohl JJ, Schmucker C Abstract BACKGROUND: Erythema migrans represents an early cutaneous and most common manifestation of Lyme borreliosis. Recommendations regarding pharmacological agents, dose and duration of treatment are subject of intense debate. This review aims to explore differences in efficacy and safety between... περισσότερα »

Analysis of the beta-propiolactone sensitivity and optimization of inactivation methods for human influenza H3N2 virus.

Alexandros G. SfakianakisστοHead and NeckΠριν από 39 δευτερόλεπτα

*Analysis of the beta-propiolactone sensitivity and optimization of inactivation methods for human influenza H3N2 virus.* J Virol Methods. 2016 Apr 30; Authors: Sasaki Y, Yoshino N, Sato S, Muraki Y Abstract Beta-propiolactone (BPL) is widely used as an inactivating reagent for influenza virus. However, the treatment of viruses with BPL occasionally results in a decrease in the hemagglutinin (HA) titer, which complicates vaccine development. In the present study, we examined the biological and biochemical characteristics of human H1N1 and H3N2 viruses treated with BPL, and develo... περισσότερα »

2014 Failed Influenza Vaccination Winter Campaign: Impact on Emergency Medical Service Calls Assessed by Telemedicine.

Alexandros G. SfakianakisστοHead and NeckΠριν από 39 δευτερόλεπτα

[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *2014 Failed Influenza Vaccination Winter Campaign: Impact on Emergency Medical Service Calls Assessed by Telemedicine.* Epidemiology. 2015 Sep;26(5):e61-2 Authors: Brunetti ND, Dellegrottaglie G, De Gennaro L, Gaglione A, Di Biase M PMID: 26164545 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1UBktZy via IFTTT

"Crude Vaccine Effectiveness" Is a Misleading Term in Test-negative Studies of Influenza Vaccine Effectiveness.

Alexandros G. SfakianakisστοHead and NeckΠριν από 39 δευτερόλεπτα

[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *"Crude Vaccine Effectiveness" Is a Misleading Term in Test-negative Studies of Influenza Vaccine Effectiveness.* Epidemiology. 2015 Sep;26(5):e60 Authors: Sullivan SG, Cowling BJ PMID: 26133018 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1SQKz6h via IFTTT

Gynecomastia and hormones

Abstract Gynecomastia—the enlargement of male breast tissue in men—is a common finding, frequently observed in newborns, adolescents, and old men. Physiological gynecomastia, occurring in almost 25 % of cases, is benign and self-limited; on the other hand, several conditions and drugs may induce proliferation of male breast tissue. True gynecomastia is a common feature often […]

Elevated inflammatory markers predict mortality in long-term ischemic stroke-survivors: a population-based prospective study

Abstract Background and aims High levels of inflammatory markers shortly after an ischemic stroke are associated with a worse prognosis. Whether inflammatory markers predict long-term mortality in stroke-survivors is less clear. We examined whether a persisting inflammatory response (levels of inflammatory markers >1 year after the stroke event) was associated with long-term mortality. Methods We […]

Imaging and simulation of Achilles tendon dynamics: implications for walking performance in the elderly

Publication date: Available online 3 May 2016 Source:Journal of Biomechanics Author(s): Jason R. Franz, Darryl G. Thelen The Achilles tendon (AT) is a complex structure, consisting of distinct fascicle bundles arising from each triceps surae muscle that may act as mechanically independent structures. Advances in tissue imaging are rapidly accelerating our understanding of the complexities […]

PRONTO: Simposio Internacional de #ecancer en Radioterapia #Chile 2016 https://t.co/UaUokkjiHR @ecanc er_espanol https://t.c…

RT @sinhuella : PRONTO: Simposio Internacional de #ecancer en Radioterapia #Chile 2016 https://t.co/UaUokkjiHR @ecancer_espanol https://t.c… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/728167816487153664 via IFTTT

Solo faltan 2 días para el https://t.co/r0IjFuIp2D te esperamos! https://t.co/U60f0GZSGE

RT @ecancer_espanol : Solo faltan 2 días para el https://t.co/r0IjFuIp2D te esperamos! https://t.co/U60f0GZSGE from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/728167799667888128 via IFTTT

Research, prevention, and the Affordable Care Act summary from #AACR16. https://t.co/oZuhVTA QqL https://t.co/VOXNber…

RT @AACR : On the blog: Research, prevention, and the Affordable Care Act summary from #AACR16. https://t.co/oZuhVTAQqL https://t.co/VOXNber… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/728167743929913344 via IFTTT

Una terapia del habla podría aliviar los problemas de memoria tras la quimio terapia https://t.co/zxvo9dv2mD https://t.…

RT @ecancer_espanol : Una terapia del habla podría aliviar los problemas de memoria tras la quimioterapia https://t.co/zxvo9dv2mD https://t.… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/728167604070813697 via IFTTT

Did you know that we identified the breast cancer gene BRCA2? https://t.co/FzYLU71JaU https://t.co/rqHrhyQB4i

RT @ICR_London : Did you know that we identified the breast cancer gene BRCA2? https://t.co/FzYLU71JaU https://t.co/rqHrhyQB4i from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/728167547447717888 via IFTTT

No te pierdas los cursos y simposios satélites en nuestro Simposio ecancer en Santiago de chile te esperamos! https:/…

RT @ecancer_espanol : No te pierdas los cursos y simposios satélites en nuestro Simposio ecancer en Santiago de chile te esperamos! https:/… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/728158399855087616 via IFTTT

Watch Dr Ying Wang explain how physical activity may improve prostate cancer prognosis: https://t.co/cBlXa0fXth

Watch Dr Ying Wang explain how physical activity may improve prostate cancer prognosis: https://t.co/cBlXa0fXth from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/728158180342005760 via IFTTT

upper respiratory tract infection; +44 new citations

Alexandros G. SfakianakisστοHead and NeckΠριν από 50 δευτερόλεπτα

44 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2016/05/05 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1WKzQPx via IFTTT

Familial adrenocortical carcinoma in association with Lynch syndrome.

Alexandros G. SfakianakisστοHead and NeckΠριν από 50 δευτερόλεπτα

*Familial adrenocortical carcinoma in association with Lynch syndrome.* J Clin Endocrinol Metab. 2016 May 4;:jc20161460 Authors: Challis BG, Kandasamy N, Powlson AS, Koulouri O, Kumar Annamalai A, Happerfield L, Marker AJ, Arends MJ, Nik-Zainal S, Gurnell M Abstract CONTEXT: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a poor prognosis. Although the majority of childhood ACC arises in the context of inherited cancer susceptibility syndromes, it remains less clear whether a hereditary tumour predisposition exists for the development of ACC in adults. Here, we ...περισσότερα »

Prediction of vertebral fractures in patients with monolateral adrenal incidentalomas.

Alexandros G. SfakianakisστοHead and NeckΠριν από 50 δευτερόλεπτα

*Prediction of vertebral fractures in patients with monolateral adrenal incidentalomas.* J Clin Endocrinol Metab. 2016 May 4;:jc20161423 Authors: Morelli V, Eller-Vainicher C, Palmieri S, Cairoli E, Stefano Salcuni A, Scillitani A, Carnevale V, Corbetta S, Arosio M, Della Casa S, Muscogiuri G, Spada A, Chiodini I Abstract CONTEXT: Subtle hypercortisolism is associated with an increased risk of vertebral fracture (VFx). OBJECTIVE: to determine the best parameters of cortisol secretion for detecting the VFx risk in patients with adrenal incidentalomas (AI). DESIGN: retrospective (cr... περισσότερα »

Diverse Genotypes and Phenotypes of Three Novel Thyroid Hormone Receptor Alpha Mutations.

Alexandros G. SfakianakisστοHead and NeckΠριν από 50 δευτερόλεπτα

*Diverse Genotypes and Phenotypes of Three Novel Thyroid Hormone Receptor Alpha Mutations.* J Clin Endocrinol Metab. 2016 May 4;:jc20161404 Authors: Demir K, van Gucht AL, Büyükinan M, Çatlı G, Ayhan Y, Nijat Bas V, Dündar B, Özkan B, Meima ME, Edward Visser W, Peeters RP, Visser TJ Abstract CONTEXT: Recently, several patients with RTHα due to T3 receptor alpha (TRα) mutations were identified. The phenotype of these patients consists of varying degrees of growth impairment, delayed bone, mental and motor development, constipation, macrocephaly, and near-normal thyroid function te... περισσότερα »

A Common CD36 Variant Influences Endothelial Function and Response to Treatment with Phosphodiesterase 5 Inhibition.

Alexandros G. SfakianakisστοHead and NeckΠριν από 50 δευτερόλεπτα

*A Common CD36 Variant Influences Endothelial Function and Response to Treatment with Phosphodiesterase 5 Inhibition.* J Clin Endocrinol Metab. 2016 May 4;:jc20161294 Authors: Shibao CA, Celedonio JE, Ramirez CE, Love-Gregory L, Arnold AC, Choi L, Okamoto LE, Gamboa A, Biaggioni I, Abumrad NN, Abumrad NA Abstract CONTEXT: The scavenger receptor CD36 influences the endothelial nitric oxide-cyclic GMP (NO-cGMP) pathway in vitro. Genetic variants that alter CD36 level are common in African Americans (AA), a population at high risk of endothelial dysfunction. OBJECTIVE: To examine if ...περισσότερα »

Contribution of heritability and epigenetic factors to skeletal muscle mass variation in UK twins.

Alexandros G. SfakianakisστοHead and NeckΠριν από 50 δευτερόλεπτα

*Contribution of heritability and epigenetic factors to skeletal muscle mass variation in UK twins.* J Clin Endocrinol Metab. 2016 May 4;:jc20161219 Authors: Livshits G, Gao F, Malkin I, Needhamsen M, Xia Y, Yuan W, Bell CG, Ward K, Liu Y, Wang J, Bell JT, Spector TD Abstract CONTEXT: Skeletal muscle mass (SMM) is one of the major components of human body composition, with deviations from normal values often leading to sarcopenia. OBJECTIVE: Our major aim was to conduct a genome-wide DNA methylation study in an attempt to identify potential genomic regions associated with SMM. DES... περισσότερα »

Association of Hypoalbuminemia with Osteoporosis: Analysis of the National Health and Nutrition Examination Survey.

Alexandros G. SfakianakisστοHead and NeckΠριν από 50 δευτερόλεπτα

*Association of Hypoalbuminemia with Osteoporosis: Analysis of the National Health and Nutrition Examination Survey.* J Clin Endocrinol Metab. 2016 May 4;:jc20161099 Authors: Afshinnia F, Pennathur S Abstract CONTEXT: The association of hypoalbuminemia with osteoporosis in human studies is controversial. OBJECTIVE: We tested the independent association between hypoalbuminemia and osteoporosis in a national dataset. DESIGN: This is a cross-sectional observation. SETTING AND PARTICIPANTS: Participants are the selected individuals from the National Health and Nutrition Examination Sur...περισσότερα »

Maladaptative autophagy impairs adipose function in Congenital Generalized Lipodystrophy due to cavin-1 deficiency.

Alexandros G. SfakianakisστοHead and NeckΠριν από 50 δευτερόλεπτα

*Maladaptative autophagy impairs adipose function in Congenital Generalized Lipodystrophy due to cavin-1 deficiency.* J Clin Endocrinol Metab. 2016 May 4;:jc20161086 Authors: Salle-Teyssières L, Auclair M, Terro F, Nemani M, Elsayed SM, Elsobky E, Lathrop M, Délépine M, Lascols O, Capeau J, Magré J, Vigouroux C Abstract CONTEXT: Mutations in PTRF encoding cavin-1 are responsible for congenital generalized lipodystrophy type 4 (CGL4) characterized by lipoatrophy, insulin resistance, dyslipidemia and muscular dystrophy. Cavin-1 cooperates with caveolins to form the plasma membrane c... περισσότερα »

Natural History of Congenital Generalized Lipodystrophy: A Nationwide Study from Turkey.

Alexandros G. SfakianakisστοHead and NeckΠριν από 50 δευτερόλεπτα

*Natural History of Congenital Generalized Lipodystrophy: A Nationwide Study from Turkey.* J Clin Endocrinol Metab. 2016 May 4;:jc20161005 Authors: Akinci B, Onay H, Demir T, Ozen S, Kayserili H, Akinci G, Nur B, Tuysuz B, Nuri Ozbek M, Gungor A, Yildirim Simsir I, Altay C, Demir L, Simsek E, Atmaca M, Topaloglu H, Bilen H, Atmaca H, Atik T, Cavdar U, Altunoglu U, Aslanger A, Mihci E, Secil M, Saygili F, Comlekci A, Garg A Abstract CONTEXT: Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by near total lack of body fat. OBJECTIVE: We ...περισσότερα »

Longitudinal associations of phospholipid and cholesteryl ester fatty acids with disorders underlying diabetes.

Alexandros G. SfakianakisστοHead and NeckΠριν από 50 δευτερόλεπτα

*Longitudinal associations of phospholipid and cholesteryl ester fatty acids with disorders underlying diabetes.* J Clin Endocrinol Metab. 2016 May 4;:jc20154267 Authors: Johnston LW, Harris SB, Retnakaran R, Zinman B, Giacca A, Liu Z, Bazinet RP, Hanley AJ Abstract CONTEXT: Specific serum fatty acid (FA) profiles predict the development of incident type 2 diabetes; however, limited longitudinal data exist exploring their role in the progression of insulin sensitivity (IS) and beta-cell function. OBJECTIVE: To examine the longitudinal associations of the FA composition of serum p... περισσότερα »

Therapy of Hypoparathyroidism with PTH(1-84): a Prospective Six Year Investigation of Efficacy and Safety.

Alexandros G. SfakianakisστοHead and NeckΠριν από 50 δευτερόλεπτα

*Therapy of Hypoparathyroidism with PTH(1-84): a Prospective Six Year Investigation of Efficacy and Safety.* J Clin Endocrinol Metab. 2016 May 4;:jc20154135 Authors: Rubin MR, Cusano NE, Fan WW, Delgado Y, Zhang C, Costa AG, Cremers S, Dworakowski E, Bilezikian JP Abstract CONTEXT: rhPTH(1-84) was recently approved for the treatment of refractory hypoparathyroidism, based upon a short term phase 3 clinical trial. Long-term data are needed since no time limit was placed on the treatment period. OBJECTIVE: We studied the effect of long-term rhPTH(1-84) treatment in hypoparathyroidi... περισσότερα »

Combination of Saxagliptin and Metformin is Effective as Initial Therapy in New Onset Type 2 Diabetes Mellitus With Severe Hyperglycemia.

Alexandros G. SfakianakisστοHead and NeckΠριν από 50 δευτερόλεπτα

*Combination of Saxagliptin and Metformin is Effective as Initial Therapy in New Onset Type 2 Diabetes Mellitus With Severe Hyperglycemia.* J Clin Endocrinol Metab. 2016 May 4;:jc20154097 Authors: Amblee A, Lious D, Fogelfeld L Abstract CONTEXT: The efficacy/safety of combination oral agents in those with stable newly diagnosed type 2 diabetes (T2DM) with severe hyperglycemia is unknown Objective: To assess glycemic and β-cell outcomes of two oral regimens Design: Open-label, randomized controlled trial with patients enrolled 2011-2014 and followed for 12 weeks Setting: Major publ...περισσότερα »

Novel synthetic plasmid and Doggybone DNA vaccines induce neutralizing antibodies and provide protection from lethal influenza challenge in mice.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

[image: http:--http://ift.tt/1XLQsFQ] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Novel synthetic plasmid and Doggybone DNA vaccines induce neutralizing antibodies and provide protection from lethal influenza challenge in mice.* Hum Vaccin Immunother. 2015;11(8):1972-82 Authors: Scott VL, Patel A, Villarreal DO, Hensley SE, Ragwan E, Yan J, Sardesai NY, Rothwell PJ, Extance JP, Caproni LJ, Weiner DB Abstract Nucleic acid-based vaccines (NAVs) are a promising alternative to conventional influenza vaccines with the potential to increase influenza vaccine availability du... περισσότερα »

Application of segmented dental panoramic tomography among children: positive effect of continuing education in radiation protection.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

*Application of segmented dental panoramic tomography among children: positive effect of continuing education in radiation protection.* Dentomaxillofac Radiol. 2016 May 4;:20160104 Authors: Pakbaznejad Esmaeili E, Waltimo-Sirén J, Laatikainen T, Haukka J, Ekholm M Abstract OBJECTIVES: Dental panoramic tomography is the most frequent examination among 7-12-year-olds according to the Radiation Safety and Nuclear Authority of Finland. At those ages, dental panoramic tomographs (DPTs) are mostly obtained for orthodontic reasons. Children's dose reduction by trimming the field-size to...περισσότερα »

Familial adrenocortical carcinoma in association with Lynch syndrome.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

Prediction of vertebral fractures in patients with monolateral adrenal incidentalomas.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

Diverse Genotypes and Phenotypes of Three Novel Thyroid Hormone Receptor Alpha Mutations.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

A Common CD36 Variant Influences Endothelial Function and Response to Treatment with Phosphodiesterase 5 Inhibition.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

Contribution of heritability and epigenetic factors to skeletal muscle mass variation in UK twins.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

Association of Hypoalbuminemia with Osteoporosis: Analysis of the National Health and Nutrition Examination Survey.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

Maladaptative autophagy impairs adipose function in Congenital Generalized Lipodystrophy due to cavin-1 deficiency.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

Natural History of Congenital Generalized Lipodystrophy: A Nationwide Study from Turkey.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

Longitudinal associations of phospholipid and cholesteryl ester fatty acids with disorders underlying diabetes.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

Therapy of Hypoparathyroidism with PTH(1-84): a Prospective Six Year Investigation of Efficacy and Safety.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

Combination of Saxagliptin and Metformin is Effective as Initial Therapy in New Onset Type 2 Diabetes Mellitus With Severe Hyperglycemia.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

Bilateral Subpectoral Interfascial Plane Catheters for Analgesia for Sternal Fractures: A Case Report.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

*Bilateral Subpectoral Interfascial Plane Catheters for Analgesia for Sternal Fractures: A Case Report.* Reg Anesth Pain Med. 2016 May 3; Authors: Raza I, Narayanan M, Venkataraju A, Ciocarlan A Abstract OBJECTIVES: Sternal fractures occur after deceleration injuries such as falls and road traffic accidents. Recovery from isolated fractures is excellent, but mortality increases dramatically with concurrent chest injuries such as rib fractures and soft tissue injuries. Short-term complications include chest pain, which prevents patients from taking deep breaths and coughing, there... περισσότερα »

The safety and efficacy of ramucirumab for the treatment of metastatic colorectal cancer.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

*The safety and efficacy of ramucirumab for the treatment of metastatic colorectal cancer.* Expert Rev Anticancer Ther. 2016 May 4; Authors: Garcia-Carbonero R, Riesco-Martinez MC, Diaz-Serrano A Abstract Ramucirumab (IMC-1121B, LY3009806) is a fully humanized monoclonal antibody that targets the extracellular domain of vascular endothelial growth factor receptor 2 (VEGFR2), the principal mediator of VEGF-A downstream effects in cancer angiogenesis. Ramucirumab has been recently approved for use in combination with FOLFIRI for the treatment of patients with metastatic colorectal ...περισσότερα »

The safety and efficacy of nivolumab for the treatment of advanced renal cell carcinoma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

*The safety and efficacy of nivolumab for the treatment of advanced renal cell carcinoma.* Expert Rev Anticancer Ther. 2016 May 4; Authors: Ornstein MC, Rini BI Abstract The cornerstone of therapy for advanced renal cell carcinoma (RCC) includes vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin (mTOR) inhibitors. Despite these therapies, outcomes for patients with advanced RCC are still not optimal. Immunotherapy with checkpoint inhibitors is a promising development in RCC and provides a new therapeutic option ... περισσότερα »

The therapeutic potential of natural killer cells to target medulloblastoma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

*The therapeutic potential of natural killer cells to target medulloblastoma.* Expert Rev Anticancer Ther. 2016 May 4; Authors: Perez-Martinez A, Fernandez L, Diaz MA PMID: 27144504 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1SOBfTM via IFTTT

Bosutinib: a third generation tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia.

Alexandros G. SfakianakisστοHead and NeckΠριν από 54 δευτερόλεπτα

Related Articles *Bosutinib: a third generation tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia.* Expert Rev Anticancer Ther. 2014 Jul;14(7):765-70 Authors: Hill BG, Kota VK, Khoury HJ Abstract Bosutinib is an oral tyrosine kinase inhibitor (TKI) with very potent dual inhibitory activity against SRC and abelson gene. Bosutinib was approved in 2012 for the treatment of resistant Philadelphia chromosome positive chronic myeloid leukemia (CML). Bosutinib is a very effective TKI against all phases of intolerant or resistant CML regardless of the presence or a... περισσότερα »

A global assessment of the male predominance in esophageal adenocarcinoma.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 56 δευτερόλεπτα

*A global assessment of the male predominance in esophageal adenocarcinoma.* Oncotarget. 2016 Apr 29; Authors: Xie SH, Lagergren J Abstract BACKGROUND: Esophageal adenocarcinoma (EAC) is characterized by a male predominance. However, variations in the sex difference across populations and over time have not previously been thoroughly investigated. RESULTS: The male-to-female ratio in EAC incidence varied greatly across continents, ranging from 1.03 in Africa to 7.64 in Northern America during 2003- 2007. The ratio was high in Europe (6.04) and Oceania (6.24), and lower in Asia (4....περισσότερα »

A comprehensive expression analysis of the MIA gene family in malignancies: MIA gene family members are novel, useful markers of esophageal, lung, and cervical squamous cell carcinoma.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 56 δευτερόλεπτα

*A comprehensive expression analysis of the MIA gene family in malignancies: MIA gene family members are novel, useful markers of esophageal, lung, and cervical squamous cell carcinoma.* Oncotarget. 2016 Apr 28; Authors: Sasahira T, Kirita T, Nishiguchi Y, Kurihara M, Nakashima C, Bosserhoff AK, Kuniyasu H Abstract Melanoma inhibitory activity (MIA) gene family members include MIA, MIA2, and Transport and Golgi organization protein 1 (TANGO). Although MIA gene family members have several tumor-related functions, their detailed roles in malignancies remain poorly elucidated. In th...περισσότερα »

Cyclin D1 expression predicts postoperative distant metastasis and survival in resectable esophageal squamous cell carcinoma.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 56 δευτερόλεπτα

*Cyclin D1 expression predicts postoperative distant metastasis and survival in resectable esophageal squamous cell carcinoma.* Oncotarget. 2016 Apr 28; Authors: Hou X, Liang RB, Wei JC, Xu Y, Fu JH, Luo RZ, He JH, Zhang LJ, Lin P, Yang HX Abstract PURPOSE: We aim to identify esophageal squamous cell carcinoma patients with increased risk of postoperative metastases. RESULTS: A high level of cyclin D1 expression, together with poor tumor cell differentiation and advanced tumor stages, increased risk of postoperative metastasis and decreased distant metastasis-free survival in ESC...περισσότερα »

The PI3K/AKT/c-MYC axis promotes the acquisition of cancer stem-like features in esophageal squamous cell carcinoma.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 56 δευτερόλεπτα

*The PI3K/AKT/c-MYC axis promotes the acquisition of cancer stem-like features in esophageal squamous cell carcinoma.* Stem Cells. 2016 May 4; Authors: Zhang HF, Wu C, Alshareef A, Gupta N, Zhao Q, Xu XE, Jiao JW, Li EM, Xu LY, Lai R Abstract The importance of intra-tumoral heterogeneity has been highlighted by the identification and characterization of cancer stem cells (CSCs). Based on the differential responsiveness to a Sox2 reporter, SRR2, we had found a novel dichotomy in esophageal squamous cell carcinoma (ESCC) cells, with reporter-responsive (RR) cells showing more CSC-l...περισσότερα »

Proximal gastrectomy versus total gastrectomy for proximal third gastric cancer: total gastrectomy is not always necessary.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 56 δευτερόλεπτα

*Proximal gastrectomy versus total gastrectomy for proximal third gastric cancer: total gastrectomy is not always necessary.* Langenbecks Arch Surg. 2016 May 4; Authors: Sugoor P, Shah S, Dusane R, Desouza A, Goel M, Shrikhande SV Abstract BACKGROUND: The appropriate extent of gastric resection for patients with proximal third gastric cancer is controversial. This study addresses whether the choice of surgical strategy (proximal gastrectomy [PG] versus total gastrectomy [TG]) influences the outcomes for proximal third gastric adenocarcinoma. MATERIALS AND METHODS: Review of prospe... περισσότερα »

Correlation Between Meis1 and Msi1 in Esophageal Squamous Cell Carcinoma.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 56 δευτερόλεπτα

*Correlation Between Meis1 and Msi1 in Esophageal Squamous Cell Carcinoma.* J Gastrointest Cancer. 2016 May 4; Authors: Moghbeli M, Rad A, Farshchian M, Taghehchian N, Gholamin M, Abbaszadegan MR Abstract PURPOSE: Homeobox (HOX) transcription factors are critical regulators of cell fate, stem cell functions, and gastrointestinal development. They require three-amino acid loop extension (TALE) homeodomain proteins such as Meis1 to enhance their transcriptional efficiencies. There are complicated associations between different signaling pathways such as the Wnt and NOTCH and tumor ... περισσότερα »

Treatment allocation in patients with early-stage esophageal adenocarcinoma: Prevalence and predictors of lymph node involvement.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 56 δευτερόλεπτα

*Treatment allocation in patients with early-stage esophageal adenocarcinoma: Prevalence and predictors of lymph node involvement.* Cancer. 2016 May 3; Authors: Gamboa AM, Kim S, Force SD, Staley CA, Woods KE, Kooby DA, Maithel SK, Luke JA, Shaffer KM, Dacha S, Saba NF, Keilin SA, Cai Q, El-Rayes BF, Chen Z, Willingham FF Abstract BACKGROUND: In considering treatment allocation for patients with early esophageal adenocarcinoma, the incidence of lymph node metastasis is a critical determinant; however, this has not been well defined or stratified by the relevant clinical predictor... περισσότερα »

Large intrauterine mass associated with cesarean scar pregnancy.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 56 δευτερόλεπτα

[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Large intrauterine mass associated with cesarean scar pregnancy.* Am J Obstet Gynecol. 2016 Jan;214(1):126.e1-2 Authors: Liu G, Shang X, Qi Z, Xue F PMID: 26342898 [PubMed - indexed for MEDLINE] from #Esophageal Cancer via xlomafota13 on Inoreader http://ift.tt/1Yaeji6 via IFTTT

Primary Malignant Melanoma of the Esophagus: A Case Report and Review of the Literature.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 56 δευτερόλεπτα

[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Primary Malignant Melanoma of the Esophagus: A Case Report and Review of the Literature.* Am J Case Rep. 2015;16:491-5 Authors: Navarro-Ballester A, De Lazaro-De Molina S, Gaona-Morales J Abstract BACKGROUND Primary malignant melanoma of the esophagus (PMME) is a rare cancer with a poor prognosis. It is often difficult to differentiate from non-epithelial malignant tumors, and immunohistochemical staining may be needed to diagnose the condition. The mainstay of treatment is usually surgical with curative or palliative intent... περισσότερα »

A global assessment of the male predominance in esophageal adenocarcinoma.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 56 δευτερόλεπτα

A comprehensive expression analysis of the MIA gene family in malignancies: MIA gene family members are novel, useful markers of esophageal, lung, and cervical squamous cell carcinoma.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 56 δευτερόλεπτα

Cyclin D1 expression predicts postoperative distant metastasis and survival in resectable esophageal squamous cell carcinoma.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 56 δευτερόλεπτα

The PI3K/AKT/c-MYC axis promotes the acquisition of cancer stem-like features in esophageal squamous cell carcinoma.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 56 δευτερόλεπτα

Proximal gastrectomy versus total gastrectomy for proximal third gastric cancer: total gastrectomy is not always necessary.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 56 δευτερόλεπτα

Neuromuscular electrical stimulation improves radiation-induced fibrosis through Tgf-Β1/MyoD homeostasis in head and neck cancer.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 57 δευτερόλεπτα

Functional Esophageal Disorders.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 57 δευτερόλεπτα

Looking into oropharyngeal dysphagia in older adults.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 57 δευτερόλεπτα

*Looking into oropharyngeal dysphagia in older adults.* Nursing. 2016 May 3; Authors: Canham M PMID: 27144326 [PubMed - as supplied by publisher] from Swallowing and Swallowing Disorders (Dysphagia) via a.lsfakia on Inoreader http://ift.tt/24tuE8A via IFTTT

Endoscopic and Abdominal Management of Complete Benign Esophageal Obstruction.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 57 δευτερόλεπτα

Videofluoroscopic Swallow Examination Does Not Accurately Detect Cricopharyngeal Radiation Strictures.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 57 δευτερόλεπτα

[The clinical, radiological and prognostic factor analysis of medullary infarction].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 57 δευτερόλεπτα

Clinical and neuroradiological features of spinocerebellar ataxia 38 (SCA38).

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 57 δευτερόλεπτα

Impaired Esophageal Mucosal Integrity May Play a Causative Role in Patients With Nongastroesophageal Reflux Disease-Related Noncardiac Chest Pain.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 57 δευτερόλεπτα

[Clinical analysis of 163 patients with remnant gastric cancer].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 57 δευτερόλεπτα

Semantic language models with deep neural networks

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 59 δευτερόλεπτα

Publication date: Available online 4 May 2016 Source:Computer Speech & Language Author(s): Ali Orkan Bayer, Giuseppe Riccardi In this paper we explore the use of semantics in training language models for automatic speech recognition and spoken language understanding. Traditional language models (LMs) do not consider the semantic constraints and train models based on fixed-sized word […]

Variations in surgeon position for palmar hand surgery

from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1ZgCuvj via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OfhtLH via IFTTT

Prevalence and Overlap of Noncardiac Conditions in the Evaluation of Low-risk Acute Chest Pain Patients.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα

Derivation and Internal Validation of the Ebola Prediction Score for Risk Stratification of Patients With Suspected Ebola Virus Disease.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα

Neurologic outcome of comatose survivors after hanging: a retrospective multicenter study

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα

The American Journal of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1ToJMc6 via IFTTT

To what extent do neighborhood differences mediate racial disparities in participation after spinal cord injury?

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα

Archives of Physical Medicine and Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/26WdK12 via IFTTT

Can radiographs of hip fractures predict subsequent hip fractures? A shape modeling analysis

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα

Injury from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1ToJKAI via IFTTT

Effect of baseline characteristics on mortality in the SURVIVE trial on the effect of levosimendan vs dobutamine in acute heart failure: Sub-analysis of the Finnish patients

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα

International Journal of Cardiology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/26WdHCx via IFTTT

The Effects of Odor Quality and Temporal Asynchrony on Modulation of Taste Intensity by Retronasal Odor.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 1 ώρα

Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 1 ώρα

Transarterial chemoembolization and sorafenib in hepatocellular carcinoma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

Related Articles *Transarterial chemoembolization and sorafenib in hepatocellular carcinoma.* Expert Rev Anticancer Ther. 2014 Jul;14(7):831-45 Authors: Cabibbo G, Tremosini S, Galati G, Mazza G, Gadaleta-Caldarola G, Lombardi G, Antonucci M, Sacco R Abstract Transarterial chemoembolization (TACE) is considered as the standard therapy for patients with intermediate-stage hepatocellular carcinoma. However, given the high heterogeneity of this population, no common strategy or protocol standardization has been defined yet. In the last few years TACE treatment has been combined with...περισσότερα »

Dendritic cell immunotherapy for glioblastoma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

Related Articles *Dendritic cell immunotherapy for glioblastoma.* Expert Rev Anticancer Ther. 2014 Jul;14(7):761-3 Authors: Polyzoidis S, Ashkan K Abstract Dendritic cell immunotherapy is emerging as a promising addition to the multimodal treatment of patients with glioblastoma multiform. Initial Phase I and II trials have demonstrated favorable outcomes with minimal toxicity. In this editorial, the current status and the future challenges of this therapy are discussed. PMID: 24850137 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http...περισσότερα »

Central nervous system toxicities of chemotherapeutic agents.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

Related Articles *Central nervous system toxicities of chemotherapeutic agents.* Expert Rev Anticancer Ther. 2014 Jul;14(7):857-63 Authors: Peddi PF, Peddi S, Santos ES, Morgensztern D Abstract Although there has been a significant progress in the recognition and management of the most common chemotherapy side effects, there is limited data on CNS toxicities. Since CNS toxicities can cause significant morbidity and delay or interruption of potentially effective therapies, there is a need for better understanding, early detection, prompt discontinuation of the offending drug, and ... περισσότερα »

Metformin blocks progression of obesity-activated thyroid cancer in a mouse model.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Metformin blocks progression of obesity-activated thyroid cancer in a mouse model.* Oncotarget. 2016 Apr 26; Authors: Park J, Kim WG, Zhao L, Enomoto K, Willingham M, Cheng SY Abstract Compelling epidemiologic evidence indicates that obesity is associated with a high risk of human malignancies, including thyroid cancer. We previously demonstrated that a high fat diet (HFD) effectively induces the obese phenotype in a mouse model of aggressive follicular thyroid cancer (ThrbPV/PVPten+/-mice). We showed that HFD promotes cancer progression through aberrant activation of the leptin...περισσότερα »

Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma.* Oncotarget. 2016 Apr 29; Authors: Zhao HD, Tang HL, Liu NN, Zhao YL, Liu QQ, Zhu XS, Jia LT, Gao CF, Yang AG, Li JT Abstract Ubiquitin-specific protease 22 (USP22) aberrance has been implicated in several malignancies; however, whether USP22 plays a role in anaplastic thyroid carcinoma (ATC) remains unclear. Here, we report that USP22 expression is highly elevated in ATC tissues, which positively correlated with tumor size, extracapsular invasion, clinical stages, and poor...περισσότερα »

Thyroglobulin levels and thyroglobulin/thyrotropin ratio could predict the success of the ablative/therapeutic (131)I in the differentiated thyroid cancers.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Thyroglobulin levels and thyroglobulin/thyrotropin ratio could predict the success of the ablative/therapeutic (131)I in the differentiated thyroid cancers.* Endocr Res. 2016 May 4;:1-7 Authors: Trevizam PG, Tagliarini JV, Castilho EC, de Alencar Marques M, Kiy Y, da Silva Mazeto GM Abstract BACKGROUND: Stimulated thyroglobulin (STg) levels in patients with differentiated thyroid carcinomas (DTCs) after total thyroidectomy (TT) and before radioactive iodine ((131)I) ablation/therapy (RIT) are predictive of therapeutic success but can be influenced by the thyroid-stimulating hor... περισσότερα »

AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy.* Oncotarget. 2016 Apr 30; Authors: Wei X, Duan W, Li Y, Zhang S, Xin X, Sun L, Gao M, Li Q, Wang D Abstract Gastric cancer remains a disease with a high mortality rate despite of multiple therapeutic strategies. So far, it is very important to develop new treatment approaches to improve current therapeutic efficacy in gastric cancer. Apurinic/apyrimidinic endonuclease (APE1) involves in DNA base excision repair (BER) during DNA damage pathway. APE1 wa... περισσότερα »

Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis.* Oncotarget. 2016 Apr 30; Authors: Champa D, Orlacchio A, Patel B, Ranieri M, Shemetov AA, Verkhusha VV, Cuervo AM, Cristofano AD Abstract Poorly differentiated and anaplastic thyroid carcinomas are very aggressive, almost invariably lethal neoplasms for which no effective treatment exists. These tumors are intrinsically resistant to cell death, even when their driver oncogenic signaling pathways are inhibited.We have undertaken a detailed analysis, in mouse and human thyroid cancer...περισσότερα »

DUSP4/MKP2 overexpression is associated with BRAF(V600E) mutation and aggressive behavior of papillary thyroid cancer.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*DUSP4/MKP2 overexpression is associated with BRAF(V600E) mutation and aggressive behavior of papillary thyroid cancer.* Onco Targets Ther. 2016;9:2255-63 Authors: Ma B, Shi R, Yang S, Zhou L, Qu N, Liao T, Wang Y, Wang Y, Ji Q Abstract The study was performed to retrospectively analyze the correlation of dual specificity phosphatase 4 (DUSP4) expression with clinicopathological variables and BRAF(V600E) mutation to better characterize the potential role of DUSP4 as a biomarker in papillary thyroid cancer (PTC). Patients (n=120) who underwent surgery for PTC at Fudan University Sh...περισσότερα »

Risk of Complications after Thyroidectomy and Parathyroidectomy: A Case Series with Planned Chart Review.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Risk of Complications after Thyroidectomy and Parathyroidectomy: A Case Series with Planned Chart Review.* Otolaryngol Head Neck Surg. 2016 May 3; Authors: Meltzer C, Klau M, Gurushanthaiah D, Titan H, Meng D, Radler L, Sundang A Abstract OBJECTIVE: To develop a predictive model for the risk of complications after thyroid and parathyroid surgery. STUDY DESIGN: Case series with planned chart review of patients undergoing surgery, 2007-2013. SETTING: Kaiser Permanente Northern California and Kaiser Permanente Southern California. SUBJECTS AND METHODS: Patients (N = 16,458) undergoi... περισσότερα »

Prognosis of patients with benign thyroid nodules: a population-based study.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Prognosis of patients with benign thyroid nodules: a population-based study.* Endocrine. 2016 May 3; Authors: Singh Ospina N, Maraka S, Espinosa de Ycaza AE, Brito JP, Castro MR, Morris JC, Montori VM Abstract Most thyroid nodules are benign. The ideal follow-up of these patients should reflect their prognosis, which has been scarcely investigated. We aimed to evaluate the prognosis of patients with initial benign thyroid cytology. A population-based study, using the Rochester Epidemiology Project, identifying patients with benign thyroid cytology diagnosed between 2003 and 200...περισσότερα »

The McGill Thyroid Nodule Score's (MTNS+) role in the investigation of thyroid nodules with benign ultrasound guided fine needle aspiration biopsies: a retrospective review.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*The McGill Thyroid Nodule Score's (MTNS+) role in the investigation of thyroid nodules with benign ultrasound guided fine needle aspiration biopsies: a retrospective review.* J Otolaryngol Head Neck Surg. 2016;45(1):29 Authors: Khalife S, Bouhabel S, Forest VI, Hier MP, Rochon L, Tamilia M, Payne RJ Abstract BACKGROUND: Ultrasound guided fine needle aspiration (USFNA) biopsies of thyroid nodules sometimes create a decision-making dilemma for surgeons as they may yield falsely benign results. The McGill Thyroid Nodule Score + (MTNS+) was developed to aid in clinical guidance rega...περισσότερα »

Less is More: Comparing the 2015 and 2009 American Thyroid Association Guidelines for Thyroid Nodules and Cancer.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Less is More: Comparing the 2015 and 2009 American Thyroid Association Guidelines for Thyroid Nodules and Cancer.* Thyroid. 2016 May 3; Authors: Kim B, Yousman WP, Wong WX, Cheng C, McAninch EA Abstract Background The American Thyroid Association (ATA) has recently revised its guidance pertaining to thyroid nodules and follicular cell-derived thyroid cancer. The 2015 guidelines are massive both in scope and scale, with changes in the organizational approach to risk stratification of nodules and cancer, as well as multiple sections covering new material. This review highlights th...περισσότερα »

Evidence-based guidelines for recommending cochlear implantation for young children: Audiological criteria and optimizing age at implantation.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Evidence-based guidelines for recommending cochlear implantation for young children: Audiological criteria and optimizing age at implantation.* Int J Audiol. 2016 May 4;:1-10 Authors: Leigh JR, Dettman SJ, Dowell RC Abstract OBJECTIVE: Establish up-to-date evidence-based guidelines for recommending cochlear implantation for young children. DESIGN: Speech perception results for early-implanted children were compared to children using traditional amplification. Equivalent pure-tone average (PTA) hearing loss for cochlear implant (CI) users was established. Language of early-implant...περισσότερα »

Charcoal suspension tattoo: new tool for the localization of malignant laterocervical lymph nodes.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Charcoal suspension tattoo: new tool for the localization of malignant laterocervical lymph nodes.* Eur Arch Otorhinolaryngol. 2016 May 3; Authors: Tirelli G, Cova MA, Zanconati F, Makuc E, Bonazza D, Tofanelli M, Di Lenarda R, Gardenal N Abstract We present a retrospective study to evaluate safety and effectiveness of ultrasound (US)-guided tattooing with charcoal of suspicious laterocervical lymph nodes. When an open biopsy of a laterocervical lymph node is needed, the choice of the lymph node to excise and examine is fundamental to avoid rebiopsy. Surgeons tend to choose the ... περισσότερα »

Proximal location in extremity long bones is a poor prognostic factor for osteosarcoma: A retrospective cohort study of 153 patients.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Proximal location in extremity long bones is a poor prognostic factor for osteosarcoma: A retrospective cohort study of 153 patients.* Acta Oncol. 2016 May 4;:1-4 Authors: Cates JM, Schoenecker JG Abstract BACKGROUND: Osteosarcomas arising in the proximal femur, humerus, and tibia appear to have poorer outcomes than those arising in distal long bones. However, the strength of this association is uncertain, particularly in light of other prognostic factors. Therefore, this retrospective cohort study was performed to compare patient outcomes between proximal and distal tumor locat...περισσότερα »

Prospective MRI-based imaging study to assess feasibility of proton therapy for post-prostatectomy radiation.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Prospective MRI-based imaging study to assess feasibility of proton therapy for post-prostatectomy radiation.* Acta Oncol. 2016 May 4;:1-6 Authors: Swisher-McClure S, Yin L, Rosen M, Batra S, Berman AT, Both S, Vapiwala N Abstract PURPOSE/OBJECTIVES: To optimize delivery of post-prostatectomy radiation (PPRT) with protons by examining dosimetric effects of variations in physician contouring, organ motion, and patient alignment during a course of PPRT. MATERIAL AND METHODS: We enrolled 10 patients receiving PPRT in a prospective imaging study. All patients underwent combined comp... περισσότερα »

Delayed nausea and vomiting from carboplatin doublet chemotherapy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Delayed nausea and vomiting from carboplatin doublet chemotherapy.* Acta Oncol. 2016 May 4;:1-5 Authors: Waqar SN, Mann J, Baggstrom MQ, Waqar MA, Chitneni P, Williams K, Gao F, Morgensztern D, Govindan R Abstract BACKGROUND: Delayed nausea and vomiting following administration of carboplatin containing chemotherapy regimen remains a clinically significant problem for patients with cancer despite administration of standard antiemetic prophylaxis comprising of a 5-HT3 antagonist and dexamethasone. We performed a prospective study to define the incidence and risk factors for delay... περισσότερα »

Prevalence and Overlap of Noncardiac Conditions in the Evaluation of Low-risk Acute Chest Pain Patients.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα

Derivation and Internal Validation of the Ebola Prediction Score for Risk Stratification of Patients With Suspected Ebola Virus Disease.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα

Homozygous HOXB1 loss-of-function mutation in a large family with hereditary congenital facial paresis.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα

*Homozygous HOXB1 loss-of-function mutation in a large family with hereditary congenital facial paresis.* Am J Med Genet A. 2016 May 4; Authors: Vogel M, Velleuer E, Schmidt-Jiménez LF, Mayatepek E, Borkhardt A, Alawi M, Kutsche K, Kortüm F Abstract Hereditary congenital facial paresis (HCFP) belongs to the congenital cranial dysinnervation disorders. HCFP is characterized by the isolated dysfunction of the seventh cranial nerve and can be associated with hearing loss, strabismus, and orofacial anomalies. Möbius syndrome shares facial palsy with HCFP, but is additionally characte...περισσότερα »

Lymph Node Micrometastases and In-Transit Metastases from Melanoma: In Vivo Detection with Multispectral Optoacoustic Imaging in a Mouse Model.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Lymph Node Micrometastases and In-Transit Metastases from Melanoma: In Vivo Detection with Multispectral Optoacoustic Imaging in a Mouse Model.* Radiology. 2016 May 4;:160191 Authors: Neuschmelting V, Lockau H, Ntziachristos V, Grimm J, Kircher MF Abstract Purpose To study whether multispectral optoacoustic tomography (MSOT) can serve as a label-free imaging modality for the detection of lymph node micrometastases and in-transit metastases from melanoma on the basis of the intrinsic contrast of melanin in comparison to fluorine 18 fluorodeoxyglucose (FDG) positron emission tomogr... περισσότερα »

MR Imaging Radiomics Signatures for Predicting the Risk of Breast Cancer Recurrence as Given by Research Versions of MammaPrint, Oncotype DX, and PAM50 Gene Assays.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*MR Imaging Radiomics Signatures for Predicting the Risk of Breast Cancer Recurrence as Given by Research Versions of MammaPrint, Oncotype DX, and PAM50 Gene Assays.* Radiology. 2016 May 5;:152110 Authors: Li H, Zhu Y, Burnside ES, Drukker K, Hoadley KA, Fan C, Conzen SD, Whitman GJ, Sutton EJ, Net JM, Ganott M, Huang E, Morris EA, Perou CM, Ji Y, Giger ML Abstract Purpose To investigate relationships between computer-extracted breast magnetic resonance (MR) imaging phenotypes with multigene assays of MammaPrint, Oncotype DX, and PAM50 to assess the role of radiomics in evaluati... περισσότερα »

Towards medicinal mechanochemistry: evolution of milling from pharmaceutical solid form screening to the synthesis of active pharmaceutical ingredients (APIs)

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 1 ώρα

[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC02015A, Feature Article Tomislav Friscic, Davin Tan, Leigh Loots This overview highlights the emergent area of mechanochemical reactions for making active pharmaceutical ingredients (APIs), and covers the latest advances in the recently established area of mechanochemical screening and synthesis... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1SOA0nv via IFTTT

A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 1 ώρα

[image: GA?id=C6CC03244C] *Chem. Commun.*, 2016, Advance Article *DOI*: 10.1039/C6CC03244C, Communication [image: Open Access] Open Access [image: Creative Commons Licence] This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Ignacio Colomer, Christopher J. Empson, Philip Craven, Zachary Owen, Richard G. Doveston, Ian Churcher, Stephen P. Marsden, Adam Nelson LLAMA was used to assess the lead-likeness of scaffolds prepared *via* complementary cyclisations of hex-2-ene-1,6-diamine derivatives. To cite this article before page numbers are assigned, use t... περισσότερα »

Observation of phase-retention behavior of HC(NH2)2PbI3 black perovskite polymorph upon mesoporous TiO2 scaffolds

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 1 ώρα

[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC02086K, Communication Yuanyuan Zhou, Joonsuh Kwun, Hector F Garces, Shuping Pang, Nitin P Padture The [small alpha]->[small delta] phase transition, which occurs favorably in planar films of black [small alpha]-HC(NH2)2PbI3 ([small alpha]-FAPbI3) perovskite in the amibent, is retarded when the [small alpha]-FAPbI3 is deposited upon mesoporous TiO2 scaffolds. It... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1q1ExYb via I... περισσότερα »

Isomorphous Template Induced Crystallisation: A Robust Method for the Targeted Crystallisation of Computationally Predicted Metastable Polymorphs.

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 1 ώρα

[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC01710J, Communication Vijay Kumar Srirambhatla, Rui Guo, Sarah L Price, Alastair James Florence A new method of inducing the crystallisation of metastable polymorphs by isomorphous templating has been developed and used to reproduce the crystallisation of CBZ-V on the surface of DHC-II. Studies... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1q1EvzJ via IFTTT

Superoxide dismutase 2 overexpression alleviates maternal diabetes-induced neural tube defects, restores mitochondrial function and suppresses cellular stress in diabetic embryopathy

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Publication date: July 2016 Source:Free Radical Biology and Medicine, Volume 96 Author(s): Jianxiang Zhong, Cheng Xu, Rinat Gabbay-Benziv, Xue Lin, Peixin Yang Pregestational diabetes disrupts neurulation leading to neural tube defects (NTDs). Oxidative stress resulting from reactive oxygen species (ROS) plays a central role in the induction of NTD formation in diabetic pregnancies. We aimed […]

Significance of microRNA-related variants in susceptibility to recurrence of oropharyngeal cancer patients after definitive radiotherapy.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Significance of microRNA-related variants in susceptibility to recurrence of oropharyngeal cancer patients after definitive radiotherapy. Oncotarget. 2016 Apr 26; Authors: Chen X, Sturgis EM, Wang C, Cao X, Li Y, Wei Q, Li G Abstract Common single nucleotide polymorphisms (SNPs) in miRNAs may affect miRNA functions and their target expression and thus may affect biological […]

Thyroglobulin levels and thyroglobulin/thyrotropin ratio could predict the success of the ablative/therapeutic (131)I in the differentiated thyroid cancers.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Thyroglobulin levels and thyroglobulin/thyrotropin ratio could predict the success of the ablative/therapeutic (131)I in the differentiated thyroid cancers. Endocr Res. 2016 May 4;:1-7 Authors: Trevizam PG, Tagliarini JV, Castilho EC, de Alencar Marques M, Kiy Y, da Silva Mazeto GM Abstract BACKGROUND: Stimulated thyroglobulin (STg) levels in patients with differentiated thyroid carcinomas (DTCs) after total […]

Neuromuscular electrical stimulation improves radiation-induced fibrosis through Tgf-Β1/MyoD homeostasis in head and neck cancer.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Neuromuscular electrical stimulation improves radiation-induced fibrosis through Tgf-Β1/MyoD homeostasis in head and neck cancer. J Surg Oncol. 2016 May 4; Authors: Peng G, Masood K, Gantz O, Sinha U Abstract OBJECTIVES: The purpose of this study was to analyze TGF-β1 and MyoD expression in cervical muscles during radiation therapy (RT) and their role in inducing […]

The Effects of Sensorineural Hearing Impairment on Asynchronous Glimpsing of Speech.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

The Effects of Sensorineural Hearing Impairment on Asynchronous Glimpsing of Speech. PLoS One. 2016;11(5):e0154920 Authors: Ozmeral EJ, Buss E, Hall JW Abstract In a previous study with normal-hearing listeners, we evaluated consonant identification masked by two or more spectrally contiguous bands of noise, with asynchronous square-wave modulation applied to neighboring bands. Speech recognition thresholds were […]

Malnutrition and Clinical Outcome of 234 Head and Neck Cancer Patients who Underwent Percutaneous Endoscopic Gastrostomy.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Malnutrition and Clinical Outcome of 234 Head and Neck Cancer Patients who Underwent Percutaneous Endoscopic Gastrostomy. Nutr Cancer. 2016 May 4;:1-9 Authors: Fonseca J, Santos CA, Brito J Abstract Head and neck cancer (HNC) patients who underwent percutaneous endoscopic gastrostomy (PEG) present malnutrition risk and speech impairments. Their assessment relies on objective anthropometric/laboratory data. Focusing […]

FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms. Oncotarget. 2016 Apr 29; Authors: Zhang X, Wu J, Luo S, Lechler T, Zhang JY Abstract FRA1 (Fos-like antigen 1) is highly expressed in many epithelial cancers including squamous cell carcinoma of the skin (cSCC) and head and neck (HNSCC). […]

Capecitabine for treating head and neck cancer.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Capecitabine for treating head and neck cancer. Expert Opin Investig Drugs. 2016 May 4; Authors: Iqbal H, Pan Q Abstract Introduction With an increasing incidence, over half a million cases of head and neck cancer (HNC) are diagnosed annually worldwide. Various chemotherapeutic agents are utilized to achieve adequate locoregional control. Cisplatin, fluorouracil (FU), and taxanes […]

Short-Term Outcomes of Acute Low-Tone Sensorineural Hearing Loss According to Treatment Modality.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Short-Term Outcomes of Acute Low-Tone Sensorineural Hearing Loss According to Treatment Modality. J Audiol Otol. 2016 Apr;20(1):47-52 Authors: Chang J, Yum G, Im HY, Jung JY, Rah YC, Choi J Abstract BACKGROUND AND OBJECTIVES: We compared improvements in hearing thresholds in acute low-tone sensorineural hearing loss (ALHL) patients after two different treatments: steroid alone and […]

Volumetric Changes in the Bony External Auditory Canal in Unilateral Chronic Otitis Media.

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Volumetric Changes in the Bony External Auditory Canal in Unilateral Chronic Otitis Media. J Audiol Otol. 2016 Apr;20(1):41-6 Authors: Park JH, Noh M, Lee CK, Park SB, Park KH, Han JK, Kim HJ Abstract BACKGROUND AND OBJECTIVES: Pneumatization of air cells in the mastoid bone is decreased in chronic otitis media (COM). A decrease in […]

Metformin blocks progression of obesity-activated thyroid cancer in a mouse model.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα

Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα

Thyroglobulin levels and thyroglobulin/thyrotropin ratio could predict the success of the ablative/therapeutic (131)I in the differentiated thyroid cancers.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα

Neuromuscular electrical stimulation improves radiation-induced fibrosis through Tgf-Β1/MyoD homeostasis in head and neck cancer.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα

AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα

Obatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosis.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα

DUSP4/MKP2 overexpression is associated with BRAF(V600E) mutation and aggressive behavior of papillary thyroid cancer.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα

Risk of Complications after Thyroidectomy and Parathyroidectomy: A Case Series with Planned Chart Review.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα

Prognosis of patients with benign thyroid nodules: a population-based study.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 1 ώρα

Does stage of cancer, comorbidity or lifestyle factors explain educational differences in survival after endometrial cancer? A cohort study among Danish women diagnosed 2005-2009.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Does stage of cancer, comorbidity or lifestyle factors explain educational differences in survival after endometrial cancer? A cohort study among Danish women diagnosed 2005-2009.* Acta Oncol. 2016 May 4;:1-6 Authors: Seidelin UH, Ibfelt E, Andersen I, Steding-Jessen M, Høgdall C, Kjær SK, Dalton SO Abstract BACKGROUND: Several studies have documented an association between socioeconomic position and survival from gynaecological cancer, but the mechanisms are unclear. OBJECTIVE: The aim of this study was to examine the association between level of education and survival after en...περισσότερα »

Proportion of women with self-reported opportunistic mammography before organized screening.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Proportion of women with self-reported opportunistic mammography before organized screening.* Acta Oncol. 2016 May 4;:1-5 Authors: Heikkinen S, Miettinen J, Koskenvuo M, Huovinen R, Pitkäniemi J, Sarkeala T, Malila N Abstract BACKGROUND: In Finland, organized nationwide breast cancer (BC) screening is biennially offered for women aged 50-69 years. The aim was to estimate, for the first time in Finland, the proportion of women having opportunistic mammography at age less than 50 years and to investigate the role of BC family history and educational level for having opportunistic ...περισσότερα »

Multiple paragangliomas of head and neck associated with hepatic paraganglioma: a case report.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Multiple paragangliomas of head and neck associated with hepatic paraganglioma: a case report.* BMC Med Imaging. 2015;15:38 Authors: Xiao Z, She D, Cao D Abstract BACKGROUND: Paragangliomas (PGs) are neuroendocrine tumors derived embryonically from the neural crest cells of the autonomic nervous system. Approximately 3 % of all paragangliomas occur in the head and neck area. Head and neck paragangliomas (HNPGs) are rare and highly vascularized tumors, the majority of which are benign. M... περισσότερα »

A coincidence or a rare occurrence? A case of plasmablastic lymphoma of the small intestines following infliximab treatment for Crohn's disease.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

[image: http:--production.springer.de-OnlineReso] Related Articles *A coincidence or a rare occurrence? A case of plasmablastic lymphoma of the small intestines following infliximab treatment for Crohn's disease.* Ann Hematol. 2016 Jan;95(1):149-50 Authors: Maung SW, Desmond R, McHugh J, Ryan B, Neary P, Jeffers M, Enright H PMID: 26361950 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1J5ADQ1 via IFTTT

Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Neuroendocrine Carcinoma of the Kidney and Bladder with Loss of Heterozygosity and Changes in Chromosome 3 Copy Number.* Am J Case Rep. 2015;16:611-6 Authors: Okada A, Iida K, Hamakawa T, Umemoto Y, Yasui T, Kawai N, Tozawa K, Sasaki S, Hayashi Y, Kohri K Abstract BACKGROUND: Neuroendocrine carcinomas (NECs) of the urological organs are observed occasionally, although simultaneous development in the kidney and blabber has not been reported. CASE REPORT: We report a case of a metastatic NEC of the kidney and bladder in a 77-y... περισσότερα »

OtoRhinoLaryngology & Medicine,New Articles,May 5th,2016

Alexandros G. SfakianakisστοMedicine by Alexandros G. SfakianakisΠριν από 1 ώρα

Salmonella enterica Subspecies diarizonae Maxillary Sinusitis in a Snake Handler: First Report *sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα* *In this study, we report the first case of reptile-associated maxillary sinusitis due to Salmonella enterica subspecies diarizonae in a snake handler and the third case of salmonella-associated sinusitis worldwide. The case highlights the potential of respiratory transmission and atypical salmonellosis present... περισσότερα »

Rasburicase-Induced Methemoglobinemia in a Patient with Aggressive Non-Hodgkin's Lymphoma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Rasburicase-Induced Methemoglobinemia in a Patient with Aggressive Non-Hodgkin's Lymphoma.* Am J Case Rep. 2015;16:590-3 Authors: Alessa MA, Craig AK, Cunningham JM Abstract BACKGROUND: Rasburicase is a recombinant urate oxidase enzyme that converts uric acid to allantoin (an inactive and soluble metabolite that is readily excreted in urine). It is used for the management of tumor lysis syndrome (TLS) in cancer patients receiving chemotherapy. Although rasburicase is a generally safe and effective treatment, it can be associ...περισσότερα »

Periodontal pocket as a potential reservoir of high risk human papilloma virus: A pilot study.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

*Periodontal pocket as a potential reservoir of high risk human papilloma virus: A pilot study.* J Indian Soc Periodontol. 2016 Mar-Apr;20(2):136-40 Authors: Dayakar MM, Shipilova A, Gupta D Abstract AIM: Human papilloma viruses (HPVs) are small DNA viruses that have been identified in periodontal pocket as well as gingival sulcus. High risk HPVs are also associated with a subset of head and neck carcinomas. HPV detection in periodontium has previously involved DNA detection. This study attempts to: (a) Detect the presence or absence of high risk HPV in marginal periodontiun by i... περισσότερα »

Thyroglobulin levels and thyroglobulin/thyrotropin ratio could predict the success of the ablative/therapeutic (131)I in the differentiated thyroid cancers.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

Less is More: Comparing the 2015 and 2009 American Thyroid Association Guidelines for Thyroid Nodules and Cancer.

Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα

Usage of allergy codes in primary care electronic health records: a national evaluation in Scotland

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα

Abstract Background The UK's NHS intends to move from the current Read code system to the international, detailed Systematized Nomenclature of Medicine Clinical Terms (SNOMED-CT) to facilitate more clinically appropriate coding of conditions and associated risk factors and outcomes. Given concerns about coding behaviour of General Practitioners, we sought to study current coding patterns in allergies and identify lessons for the future migration to SNOMED-CT. Methods Data from 2,014,551 primary-care consultations in over 100,000 patients with one or more of 11 potentially allerg...περισσότερα »

Usage of allergy codes in primary care electronic health records: a national evaluation in Scotland

sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Abstract Background The UK’s NHS intends to move from the current Read code system to the international, detailed Systematized Nomenclature of Medicine Clinical Terms (SNOMED-CT) to facilitate more clinically appropriate coding of conditions and associated risk factors and outcomes. Given concerns about coding behaviour of General Practitioners, we sought to study current coding patterns in […]

Neuromuscular electrical stimulation improves radiation-induced fibrosis through Tgf-Β1/MyoD homeostasis in head and neck cancer.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα

3D scanning and printing skeletal tissues for anatomy education

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα

Abstract Detailed anatomical models can be produced with consumer-level 3D scanning and printing systems. 3D replication techniques are significant advances for anatomical education as they allow practitioners to more easily introduce diverse or numerous specimens into classrooms. Here we present a methodology for producing anatomical models in-house, with the chondrocranium cartilage from a spiny dogfish (*Squalus acanthias*) and the skeleton of a cane toad (*Rhinella marina*) as case studies. 3D digital replicas were produced using two consumer-level scanners and specimens were ... περισσότερα »

Genomic variation of Epstein-Barr virus in inflammatory pseudotumor-like follicular dendritic cell tumor

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα

Abstract Inflammatory pseudotumor-like follicular dendritic cell (FDC) tumor is a rare neoplasm characterized by proliferation of spindle to ovoid tumor cells showing morphologic and immunophenotypic features of FDC with intense lymphoplasmacytic infiltrate1. The tumor almost invariably involves the spleen or liver and is consistently associated with Epstein-Barr virus (EBV) infection2, 3. According to the sequence divergence of EBNA-3 gene, EBV has two distinct strains, subtype A and subtype B4. This article is protected by copyright. All rights reserved. from Anatomy Pathology ...περισσότερα »

Heterogeneous firing rate response of mice layer V pyramidal neurons in the fluctuation-driven regime

Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 2 ώρες

Abstract Characterizing the input-output properties of neocortical neurons is of crucial importance to understand the properties emerging at the network level. In the regime of low-rate irregular firing (such as in the *awake* state) determining those properties for neocortical cells remains, however, both experimentally and theoretically challenging. Here, we studied this problem using a combination of theoretical modeling and *in vitro* experiments. We first identified, theoretically, three somatic variables that describe the dynamical state at the soma in this *fluctuation-driven... περισσότερα »

The transcription factor NeuroD2 coordinates synaptic innervation and cell intrinsic properties to control excitability of cortical pyramidal neurons

Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 2 ώρες

Synaptic excitation and inhibition must be properly balanced in individual neurons and neuronal networks for proper brain function. Disruption of this balance during development may lead to autism spectral disorders and epilepsy. Synaptic excitation is counter-balanced by synaptic inhibition but also by regulation attenuation of cell-intrinsic neuronal excitability. To maintain proper excitation levels during development, neurons must sense activity over time and regulate the expression of genes that control these parameters. While this is a critical process, little is known about ... περισσότερα »

The Effects of Odor Quality and Temporal Asynchrony on Modulation of Taste Intensity by Retronasal Odor.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 2 ώρες

Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 2 ώρες

The Effects of Odor Quality and Temporal Asynchrony on Modulation of Taste Intensity by Retronasal Odor.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 2 ώρες

Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 2 ώρες

The McGill Thyroid Nodule Score's (MTNS+) role in the investigation of thyroid nodules with benign ultrasound guided fine needle aspiration biopsies: a retrospective review.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 2 ώρες

Less is More: Comparing the 2015 and 2009 American Thyroid Association Guidelines for Thyroid Nodules and Cancer.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 2 ώρες

Correlation Between Meis1 and Msi1 in Esophageal Squamous Cell Carcinoma.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 2 ώρες

Treatment allocation in patients with early-stage esophageal adenocarcinoma: Prevalence and predictors of lymph node involvement.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 2 ώρες

Large intrauterine mass associated with cesarean scar pregnancy.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 2 ώρες

Related Articles *Large intrauterine mass associated with cesarean scar pregnancy.* Am J Obstet Gynecol. 2016 Jan;214(1):126.e1-2 Authors: Liu G, Shang X, Qi Z, Xue F PMID: 26342898 [PubMed - indexed for MEDLINE] from pubmed: esophageal cancer http://ift.tt/1Yaeji6 via IFTTT

Primary Malignant Melanoma of the Esophagus: A Case Report and Review of the Literature.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 2 ώρες

Related Articles *Primary Malignant Melanoma of the Esophagus: A Case Report and Review of the Literature.* Am J Case Rep. 2015;16:491-5 Authors: Navarro-Ballester A, De Lazaro-De Molina S, Gaona-Morales J Abstract BACKGROUND Primary malignant melanoma of the esophagus (PMME) is a rare cancer with a poor prognosis. It is often difficult to differentiate from non-epithelial malignant tumors, and immunohistochemical staining may be needed to diagnose the condition. The mainstay of treatment is usually surgical with curative or palliative intent, since radio- and chemotherapy do no... περισσότερα »

Less is More: Comparing the 2015 and 2009 American Thyroid Association Guidelines for Thyroid Nodules and Cancer.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 2 ώρες

Diagnostic accuracy of fine needle aspiration biopsy for detection of malignancy in pediatric thyroid nodules: protocol for a systematic review and meta-analysis.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 2 ώρες

Related Articles *Diagnostic accuracy of fine needle aspiration biopsy for detection of malignancy in pediatric thyroid nodules: protocol for a systematic review and meta-analysis.* Syst Rev. 2015;4:120 Authors: Lai SW, Roberts DJ, Rabi DM, Winston KY Abstract BACKGROUND: Fine needle aspiration biopsy (FNAB) is an accurate test commonly used to determine whether thyroid nodules are malignant in adults. However, less is known about its diagnostic accuracy for this purpose in children, where conduct of FNAB is less frequent, more technically challenging, and pre-test probabilities... περισσότερα »

[A bulky lateral cervical mass].

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 2 ώρες

Related Articles *[A bulky lateral cervical mass].* Med Sante Trop. 2015 Apr-Jun;25(2):133-5 Authors: Jarry J, Raynaud L, Buisson P, Blegole Oble C Abstract Branchial cysts are rare, benign cervical lesions that can mimic thyroid goiters, in particular in areas where goiters are endemic. This case describes an Ivorian patient who presented with what appeared to be a voluminous thyroid goiter. At surgery, it proved to be a cyst of the second pharyngeal arch. PMID: 26039459 [PubMed - indexed for MEDLINE] from pubmed: thyroid cancer http://ift.tt/24to0iR via IFTTT

Neuromuscular electrical stimulation improves radiation-induced fibrosis through Tgf-Β1/MyoD homeostasis in head and neck cancer.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 2 ώρες

3D scanning and printing skeletal tissues for anatomy education

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 2 ώρες

Effect of recombinant PDGF-BB on bone formation in the presence of β-tricalcium phosphate and bovine bone mineral matrix: a pilot study in rat calvarial defects

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 2 ώρες

AbstractBackground Supplementation of bone substitutes with recombinant platelet-derived growth factor-BB (PDGF-BB) can enhance bone regeneration. The aim of the study was to evaluate the effect of PDGF-BB on bone formation in the presence of β-tricalcium phosphate and bovine bone mineral matrix in a rat calvaria defect model. Methods The authors examined 5 mm rat calvarial defects treated with β-tricalcium phosphate (TCP) or demineralized bovine bone mineral (DBBM) with and without 0.3 mg/ml recombinant PDGF-BB. Calvaria defects were randomly divided into the following treatment g... περισσότερα »

Disc position in clinically asymptomatic, pretreatment adolescents with Class I, II, or III malocclusion

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 2 ώρες

AbstractObjective To test the null hypothesis that children with Class I, II, and III malocclusions who have not undergone orthodontic therapy present with displaced discs. Materials and methods This study relied on retrospective material consisting of 76 unilateral left sagittal–oblique temporomandibular joint (TMJ) magnetic resonance imaging (MRIs) and lateral cephalometric radiographs taken in maximum intercuspal position in patients with clinically symptom-free and orthodontically untreated Class I (*n* = 30; 19 girls and 11 boys), Class II (*n* = 26; 10 girls and 16 boys), and...περισσότερα »

Alternate rapid maxillary expansion–constriction and tooth-borne symphyseal distraction osteogenesis

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 2 ώρες

Abstract Surgically assisted rapid mandibular expansion is a contemporary treatment alternative to enable genuine skeletal mandibular widening. Mandibular widening via a tooth-borne distractor is a practical and noninvasive clinical approach. Recently, to expand and protract the maxilla, the alternate rapid maxillary expansion-and-constriction procedure was suggested. In this case report, we describe a female patient (12 years 7 months old) having severe maxillary and mandibular crowding who underwent repeated alternate rapid maxillary expansion and constriction in combination with... περισσότερα »

Neuromuscular electrical stimulation improves radiation-induced fibrosis through Tgf-Β1/MyoD homeostasis in head and neck cancer.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 2 ώρες

Sleep physiology predicts memory retention after reactivation

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες

Summary Both sleep and future relevance influence memory consolidation; however, limited research has investigated their role in memory reconsolidation. We manipulated the future relevance of both stable and labile memories in need of reconsolidation. Two groups learned two blocks of syllable pairs on one evening and were told they would be tested on one of […]

Human amygdala activation during rapid eye movements of rapid eye movement sleep: an intracranial study

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες

Summary The amygdaloid complex plays a crucial role in processing emotional signals and in the formation of emotional memories. Neuroimaging studies have shown human amygdala activation during rapid eye movement sleep (REM). Stereotactically implanted electrodes for presurgical evaluation in epileptic patients provide a unique opportunity to directly record amygdala activity. The present study analysed amygdala […]

3D scanning and printing skeletal tissues for anatomy education

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες

A Volumetric Approach to Wake Reduction: Design, Optimization, and Experimental Verification

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες

Wake reduction is a crucial link in the chain leading to undetectable watercraft. Here, we explore a volumetric approach to controlling the wake in a stationary flow past cylindrical and spherical objects. In this approach, these objects are coupled with rigid, fluid-permeable structures prescribed by a macroscopic design approach where all solid boundaries are parameterized […]

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Πέμπτη 5 Μαΐου 2016

OtoRhinoLaryngology & Medicine,New Articles,May 5th,2016,a