Head and Neck Medicine by Alexandros G.Sfakianakis: 05/06/16

Παρασκευή 6 Μαΐου 2016

OtoRhinoLaryngology & Medicine,New Articles,May 6th,2016,a

Paraprosthetic Erosion of the Ileum after an Aorto-femoral Bypass

Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 27 δευτερόλεπτα

Publication date: Available online 6 May 2016 *Source:*European Journal of Vascular and Endovascular Surgery Author(s): F. Famá, R. Gaeta from Endocrinology via ola Kala on Inoreader http://ift.tt/21DB4wW via IFTTT

Walking Capacity Is Positively Related with Heart Rate Variability in Symptomatic Peripheral Artery Disease

Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 27 δευτερόλεπτα

Publication date: Available online 6 May 2016 *Source:*European Journal of Vascular and Endovascular Surgery Author(s): A.H.R.A. Lima, A.H.G. Soares, G.G. Cucato, A.S. Leicht, F.G.M. Franco, N. Wolosker, R.M. Ritti-Dias ObjectivesThe aim was to investigate the association between walking capacity and HRV in patients with symptomatic peripheral artery disease (PAD).MethodsThis was a cross sectional study. Ninety-five patients were recruited. Patients undertook a supine position for 20 minutes, with the final 10 minutes used to examine for resting HRV. Time domain, frequency domain, a...περισσότερα »

Iliac Artery Endofibrosis

Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 27 δευτερόλεπτα

Publication date: Available online 6 May 2016 *Source:*European Journal of Vascular and Endovascular Surgery Author(s): R.J. Hinchliffe from Endocrinology via ola Kala on Inoreader http://ift.tt/21DB3c7 via IFTTT

Formaldehyde Induces Rho-associated Kinase Activity to Evoke Airway Hyperresponsiveness.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 5 δευτερόλεπτα

*Formaldehyde Induces Rho-associated Kinase Activity to Evoke Airway Hyperresponsiveness.* Am J Respir Cell Mol Biol. 2016 May 5; Authors: Jude J, Koziol-White C, Scala J, Yoo E, Jester W, Maute C, Dalton P, Panettieri R Abstract BACKGROUND: Formaldehyde, a common indoor air pollutant, exacerbates asthma and synergizes with allergen to induce airway hyperresponsiveness (AHR) in animal models. The mechanisms mediating formaldehyde-induced AHR remain poorly understood. We posit that formaldehyde modulates agonist-induced contractile response of human airway smooth muscle (HASM) cel... περισσότερα »

Formaldehyde Induces Rho-associated Kinase Activity to Evoke Airway Hyperresponsiveness.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 6 δευτερόλεπτα

Formaldehyde Induces Rho-associated Kinase Activity to Evoke Airway Hyperresponsiveness.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 6 δευτερόλεπτα

Formaldehyde Induces Rho-associated Kinase Activity to Evoke Airway Hyperresponsiveness.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 6 δευτερόλεπτα

Formaldehyde Induces Rho-associated Kinase Activity to Evoke Airway Hyperresponsiveness.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 6 δευτερόλεπτα

Adverse Reaction to Cetuximab, an Epidermal Growth Factor Receptor Inhibitor.

Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα

*Adverse Reaction to Cetuximab, an Epidermal Growth Factor Receptor Inhibitor.* Acta Dermatovenerol Croat. 2016 Apr;24(1):70-72 Authors: Štulhofer Buzina D, Martinac I, Ledić Drvar D, Čeović R, Bilić I, Marinović B Abstract Dear Editor, Inhibition of the epidermal growth factor receptor (EGFR) is a new strategy in treatment of a variety of solid tumors, such as colorectal carcinoma, non-small cell lung cancer, squamous cell carcinoma of the head and neck, and pancreatic cancer (1). Cetuximab is a chimeric human-murine monoclonal antibody against EGFR. Cutaneous side effects are t...περισσότερα »

Diagnostic whole body scan (pre-therapy scan) in differentiated thyroid cancer: A single center community hospital experience.

Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα

*Diagnostic whole body scan (pre-therapy scan) in differentiated thyroid cancer: A single center community hospital experience.* Indian J Cancer. 2016 Jan-Mar;53(1):178-80 Authors: Santhanam P, Driscoll HK, Venkatraman P Abstract OBJECTIVE: Diagnostic whole body scan (pre-therapy scan) with either I-123 or I-131 (radioactive isotopes of iodine) is performed to assess the extent of thyroid cancer especially distant metastasis prior to administering the therapeutic dose of I-131. Our aim of the following study was to determine the utility of the diagnostic pre-therapy scan in the ma... περισσότερα »

Upper Respiratory Tract Infections

Alexandros G. SfakianakisστοHead and NeckΠριν από 9 δευτερόλεπτα

48 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2016/05/06 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1STyNb8 via IFTTT

ABC transporters and the proteasome complex are implicated in susceptibility to Stevens-Johnson syndrome and toxic epidermal necrolysis across multiple drugs.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα

[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *ABC transporters and the proteasome complex are implicated in susceptibility to Stevens-Johnson syndrome and toxic epidermal necrolysis across multiple drugs.* PLoS One. 2015;10(6):e0131038 Authors: Nicoletti P, Bansal M, Lefebvre C, Guarnieri P, Shen Y, Pe'er I, Califano A, Floratos A Abstract Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) represent rare but serious adverse drug reactions (ADRs). Both are characterized by distinctive blistering lesions and signific... περισσότερα »

Unusual Eruptions Associated with Mycoplasma pneumoniae Respiratory Infections: Review of the Literature.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα

[image: http:--misc.karger.com-LinkOutIcons-sk_n] Related Articles *Unusual Eruptions Associated with Mycoplasma pneumoniae Respiratory Infections: Review of the Literature.* Dermatology. 2015;231(2):152-7 Authors: Terraneo L, Lava SA, Camozzi P, Zgraggen L, Simonetti GD, Bianchetti MG, Milani GP Abstract BACKGROUND: Maculopapular or urticarial eruptions and erythema multiforme sometimes occur in patients affected with Mycoplasma pneumoniae respiratory infections. Further eruptions have also been reported. OBJECTIVE: To review the literature addressing M. pneumoniae respiratory i... περισσότερα »

Comparison of Patient- and Practitioner-Reported Toxic Effects Associated With Chemoradiotherapy for Head and Neck Cancer.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα

*Comparison of Patient- and Practitioner-Reported Toxic Effects Associated With Chemoradiotherapy for Head and Neck Cancer.* JAMA Otolaryngol Head Neck Surg. 2016 May 5; Authors: Falchook AD, Green R, Knowles ME, Amdur RJ, Mendenhall W, Hayes DN, Grilley-Olson JE, Weiss J, Reeve BB, Mitchell SA, Basch EM, Chera BS Abstract Importance: Agreement between patient- and practitioner-reported toxic effects during chemoradiotherapy for head and neck cancer is unknown. Objective: To compare patient-reported symptom severity and practitioner-reported toxic effects among patients receiving ... περισσότερα »

Comparison of Conventional, Revascularized, and Bioengineered Methods of Recurrent Laryngeal Nerve Reconstruction.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα

*Comparison of Conventional, Revascularized, and Bioengineered Methods of Recurrent Laryngeal Nerve Reconstruction.* JAMA Otolaryngol Head Neck Surg. 2016 May 5; Authors: Sand JP, Park AM, Bhatt N, Desai SC, Marquardt L, Sakiyama-Elbert S, Paniello RC Abstract Importance: Damage to the recurrent laryngeal nerve (RLN) is highly detrimental to voice, swallow, and cough. The optimal method for reconstitution of a nerve gap after injury is unknown. Objective: To evaluate multiple methods of RLN reconstruction. Design, Setting, and Participants: This study used an established canine mo...περισσότερα »

Effect of Basic Fibroblast Growth Factor in Tympanic Membrane Perforation.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα

*Effect of Basic Fibroblast Growth Factor in Tympanic Membrane Perforation.* JAMA Otolaryngol Head Neck Surg. 2016 May 5; Authors: Lou Z, Fu Y PMID: 27149323 [PubMed - as supplied by publisher] from #ORL via xlomafota13 on Inoreader http://ift.tt/1WdLyDV via IFTTT

Patient-Reported Toxic Effects-The Dawn of a New Era.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα

*Patient-Reported Toxic Effects-The Dawn of a New Era.* JAMA Otolaryngol Head Neck Surg. 2016 May 5; Authors: Worden FP PMID: 27149196 [PubMed - as supplied by publisher] from #ORL via xlomafota13 on Inoreader http://ift.tt/1OgFJwX via IFTTT

Painless, Nonhealing Submental Ulcer.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα

*Painless, Nonhealing Submental Ulcer.* JAMA Otolaryngol Head Neck Surg. 2016 May 5; Authors: O'Toole TR, Ghai R, Nielsen T PMID: 27149053 [PubMed - as supplied by publisher] from #ORL via xlomafota13 on Inoreader http://ift.tt/1WdLvrJ via IFTTT

Further delineation of FKBP14-related Ehlers-Danlos syndrome: A patient with early vascular complications and non-progressive kyphoscoliosis, and literature review.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα

*Further delineation of FKBP14-related Ehlers-Danlos syndrome: A patient with early vascular complications and non-progressive kyphoscoliosis, and literature review.* Am J Med Genet A. 2016 May 5; Authors: Dordoni C, Ciaccio C, Venturini M, Calzavara-Pinton P, Ritelli M, Colombi M Abstract FKBP14-related Ehlers-Danlos syndrome (EDS) is an extremely rare recessive connective tissue disorder described for the first time in 2012 by Baumann and coworkers. The causal gene, FKBP14, encodes a member of the F506-binding family of peptidyl-prolyl cis-trans isomerases. The paucity of pati... περισσότερα »

Child abuse and fabricated or induced illness in the ENT setting: a systematic review.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 12 δευτερόλεπτα

*Child abuse and fabricated or induced illness in the ENT setting: a systematic review.* Clin Otolaryngol. 2016 May 5; Authors: Rees P, Al-Hussaini A, Maguire S Abstract BACKGROUND: Child maltreatment is persistently under-recognised. Given that a third of maltreated children may return with serious or fatal injuries, it is imperative that otolaryngologists who are in frequent contact with children are able to detect maltreatment at first presentation. OBJECTIVE OF REVIEW: This review aims to identify ENT injuries, signs or symptoms that are indicative of physical abuse or fabrica... περισσότερα »

Salivary FOXP2 expression and oral feeding success in premature infants.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 13 δευτερόλεπτα

*Salivary FOXP2 expression and oral feeding success in premature infants.* Cold Spring Harb Mol Case Stud. 2016 Jan;2(1):a000554 Authors: Zimmerman E, Maki M, Maron J Abstract The objective of the study is to determine whether salivary FOXP2 gene expression levels at the initiation of oral feeding attempts are predictive of oral feeding success in the premature newborn. In this prospective study, saliva samples from 21 premature infants (13 males; birth gestational age [GA]: 30-34 wk) were collected around the initiation of oral feeding trials. Total RNA was extracted and underwen...περισσότερα »

Valproate ameliorates nitroglycerin-induced migraine in trigeminal nucleus caudalis in rats through inhibition of NF-кB

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 13 δευτερόλεπτα

As a complex nervous system disease, migraine causes severe healthy and social issues worldwide. Valproate (VPA) is a widely used treatment agent against seizures and bipolar disorder, and its function to alle... from #ENT via xlomafota13 on Inoreader http://ift.tt/1WcjJv1 via IFTTT

Formaldehyde Induces Rho-associated Kinase Activity to Evoke Airway Hyperresponsiveness.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 13 δευτερόλεπτα

[Transthoracic myotomy of a case of giant megaesophagus in Mali hospital].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 13 δευτερόλεπτα

[image: http:--http://ift.tt/1MOzwGw] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *[Transthoracic myotomy of a case of giant megaesophagus in Mali hospital].* Pan Afr Med J. 2015;21:239 Authors: Togo S, Abdoulaye OM, Xing L, Sadio Y PMID: 26523179 [PubMed - indexed for MEDLINE] from #ENT via xlomafota13 on Inoreader http://ift.tt/1rxUNBM via IFTTT

Randomised clinical trial: transoral incisionless fundoplication vs. sham intervention to control chronic GERD.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 13 δευτερόλεπτα

[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Randomised clinical trial: transoral incisionless fundoplication vs. sham intervention to control chronic GERD.* Aliment Pharmacol Ther. 2015 Dec;42(11-12):1261-70 Authors: Håkansson B, Montgomery M, Cadiere GB, Rajan A, Bruley des Varannes S, Lerhun M, Coron E, Tack J, Bischops R, Thorell A, Arnelo U, Lundell L Abstract BACKGROUND: Until recently only two therapeutic options have been available to control symptoms and the esophagitis in chronic gastro-oesophageal reflux disease (GERD), i.e. lifelong proton pump ... περισσότερα »

Oesophageal signet ring cell carcinoma as complication of gastro-oesophageal reflux disease.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 13 δευτερόλεπτα

[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Oesophageal signet ring cell carcinoma as complication of gastro-oesophageal reflux disease.* Aliment Pharmacol Ther. 2015 Nov;42(10):1222-31 Authors: Turner KO, Genta RM, Sonnenberg A Abstract BACKGROUND: Signet ring cell carcinoma occurs as a histological variant of oesophageal adenocarcinoma. AIM: In a cross-sectional study, to pursue the hypothesis that oesophageal signet ring cell cancers constitute a complication of gastro-oesophageal reflux disease. METHODS: In a large national database of histopathology re... περισσότερα »

Delayed hypersensitivity reaction after cervical disc replacement: a case report.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 13 δευτερόλεπτα

[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Delayed hypersensitivity reaction after cervical disc replacement: a case report.* Orthop Traumatol Surg Res. 2015 Sep;101(5):643-5 Authors: Lagier M, Briere M, Giorgi H, Fuentes S, Blondel B, Tropiano P Abstract We report a case of allergic reaction after total cervical disc arthroplasty. A 52-year old woman was operated on for right C6 cervicobrachial neuralgia secondary to C5-C6 disc disease with foraminal stenosis. A cobalt-chromium-molybdenum total disc prosthesis had been implanted two years earlier. The pa... περισσότερα »

Gastroesophageal reflux and lung disease.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 13 δευτερόλεπτα

Related Articles *Gastroesophageal reflux and lung disease.* Expert Rev Respir Med. 2015 Aug;9(4):383-5 Authors: Meyer KC Abstract Gastroesophageal reflux (GER) can cause respiratory symptoms and may trigger, drive and/or worsen airway disorders, interstitial lung diseases and lung allograft dysfunction. Whether lifestyle changes and acid suppression alone can counter and prevent the adverse effects of GER on the respiratory tract remains unclear. Recent data suggest that antireflux surgery may be more effective in preventing lung disease progression in patients with idiopathic ... περισσότερα »

Clinical outcomes in patients with a diagnosis of "indefinite for dysplasia" in Barrett's esophagus: a multicenter cohort study.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 13 δευτερόλεπτα

[image: http:--http://ift.tt/1SvbKVd] Related Articles *Clinical outcomes in patients with a diagnosis of "indefinite for dysplasia" in Barrett's esophagus: a multicenter cohort study.* Endoscopy. 2015 Aug;47(8):669-74 Authors: Sinh P, Anaparthy R, Young PE, Gaddam S, Thota P, Balasubramanian G, Singh M, Higbee AD, Wani S, Gupta N, Rastogi A, Mathur SC, Bansal A, Horwhat JD, Cash BD, Falk GW, Lieberman DA, Vargo JJ, Sampliner RE, Sharma P Abstract BACKGROUND AND STUDY AIM: Data are limited on the natural history of patients with Barrett's esophagus with a diagnosis of "indefinite ... περισσότερα »

More art than science: impedance analysis prone to interpretation error.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 13 δευτερόλεπτα

[image: http:--production.springer.de-OnlineReso] Related Articles *More art than science: impedance analysis prone to interpretation error.* J Gastrointest Surg. 2015 Jun;19(6):987-92 Authors: Ciecierega T, Gordon BL, Aronova A, Crawford CV, Zarnegar R Abstract BACKGROUND: Impedance monitoring for reflux evaluation does not have standardized scoring, which can confound interpretation between observers. We investigated the variability of impedance testing interpretation between physicians and computer software. METHODS: Raw impedance data from 38 patients that underwent impedance ... περισσότερα »

Perspectives on the role of the speech and language therapist in palliative care: An international survey.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 13 δευτερόλεπτα

Related Articles *Perspectives on the role of the speech and language therapist in palliative care: An international survey.* Palliat Med. 2015 Sep;29(8):756-61 Authors: O'Reilly AC, Walshe M Abstract BACKGROUND: Speech and language therapists can improve the quality of life of people receiving palliative care through the management of communication and swallowing difficulties (dysphagia). However, their role in this domain is poorly defined and little is understood about the current international professional practice in this field. AIMS: To examine how speech and language thera... περισσότερα »

Galectin-1 is essential for the induction of MOG35-55-based intravenous tolerance in experimental autoimmune encephalomyelitis

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 13 δευτερόλεπτα

[image: cover.gif?v=1&s=b21358abd3cdaaa7c9eaac8d] In experimental autoimmune encephalomyelitis (EAE), intravenous (i.v.) injection of the antigen, myelin oligodendrocyte glycoprotein-derived peptide, MOG35-55, suppresses disease development, a phenomenon called i.v. tolerance. Galectin-1, an endogenous glycan-binding protein, is upregulated during autoimmune neuroinflammation and plays immunoregulatory roles by inducing tolerogenic dendritic cells (DCs) and IL-10-producing regulatory type 1 T (Tr1) cells. To examine the role of galectin-1 in i.v. tolerance, we administered MOG35-5... περισσότερα »

Key roles of autophagy in regulating T-cell function

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 13 δευτερόλεπτα

Abstract In the past 10 years, autophagy has emerged as a crucial regulator of T-cell homeostasis, activation and differentiation. Through the ability to adjust the cell's proteome in response to different stimuli, different forms of autophagy have been shown to control T-cell homeostasis and survival. Autophagic processes can also determine the magnitude of the T-cell response to TCR engagement, by regulating the cellular levels of specific signaling intermediates and modulating the metabolic output in activated T cells. In this review we will examine the mechanisms that control ... περισσότερα »

Activation of murine invariant NKT cells promotes susceptibility to candidiasis by IL-10-induced modulation of phagocyte antifungal activity

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 13 δευτερόλεπτα

[image: cover.gif?v=1&s=b21358abd3cdaaa7c9eaac8d] Invariant NKT (iNKT) cells play an important role in a variety of antimicrobial immune responses due to their ability to produce high levels of immunemodulating cytokines. Here, we investigated the role of iNKT cells in host defense against candidiasis using *Jα18*-deficient mice (*Jα18*−/−), which lack iNKT cells. *Jα18*−/- mice were more resistant to the development of lethal candidiasis than wild-type (WT) mice. In contrast, treatment of WT mice with the iNKT cell activating ligand α-galactosylceramide markedly enhanced their mo...περισσότερα »

Cell origin in the macula flava of the human newborn vocal fold

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 13 δευτερόλεπτα

Research Articles K Sato, S Chitose, T Kurita, H Umeno The Journal of Laryngology & Otology,FirstView Article(s), 6 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #ENT via xlomafota13 on Inoreader http://ift.tt/1O2eGuu via IFTTT

Development of an item bank for the EORTC Role Functioning Computer Adaptive Test (EORTC RF-CAT)

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 14 δευτερόλεπτα

Role functioning (RF) as a core construct of health-related quality of life (HRQOL) comprises aspects of occupational and social roles relevant for patients in all treatment phases as well as for survivors. Th… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1rZKkj0 via IFTTT

Osterix and RUNX2 are Transcriptional Regulators of Sclerostin in Human Bone

Abstract Sclerostin, encoded by the SOST gene, works as an inhibitor of the Wnt pathway and therefore is an important regulator of bone homeostasis. Due to its potent action as an inhibitor of bone formation, blocking sclerostin activity is the purpose of recently developed anti-osteoporotic treatments. Two bone-specific transcription factors, RUNX2 and OSX, have been […]

Health Technology

216 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: health technology These pubmed results were generated on 2016/05/06 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content […]

Antibiotics, Vol. 5, Pages 15: Antibiotics and RNase P

RNase P is an essential endonuclease in tRNA biogenesis, which generates the mature 5′-termini of tRNAs. Most forms of RNase P are ribonucleoproteins, i.e., they consist of an essential RNA and protein subunits. The catalytic function of ribonucleoprotein RNase P enzymes resides entirely in the RNA subunit. Its high structural and functional diversity among representatives […]

A Radiomics Nomogram for Preoperative Prediction of Lymph Node Metastasis

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 14 δευτερόλεπτα

Development and Validation of a Radiomics Nomogram for Preoperative Prediction of Lymph Node Metastasis in Colorectal Cancer [Gastrointestinal Cancer]: Purpose To develop and validate a radiomics nomogram for preoperative prediction of lymph node (LN) metastasis in patients with colorectal cancer (CRC). Patients and Methods The prediction model was developed in a primary cohort that consisted of 326 patients with clinicopathologically confirmed CRC, and data was gathered from January 2007 to April 2010. Radiomic features were extracted from portal venous–phase computed tomography (... περισσότερα »

Child abuse and fabricated or induced illness in the ENT setting: a systematic review.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 14 δευτερόλεπτα

Salivary FOXP2 expression and oral feeding success in premature infants.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 14 δευτερόλεπτα

FOXP2 gene deletion and infant feeding difficulties: a case report.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 14 δευτερόλεπτα

*FOXP2 gene deletion and infant feeding difficulties: a case report.* Cold Spring Harb Mol Case Stud. 2016 Jan;2(1):a000547 Authors: Zimmerman E, Maron JL Abstract Forkhead box protein P2 (FOXP2) is a well-studied gene known to play an essential role in normal speech development. Deletions in the gene have been shown to result in developmental speech disorders and regulatory disruption of downstream gene targets associated with common forms of language impairments. Despite similarities in motor planning and execution between speech development and oral feeding competence, there ha... περισσότερα »

Gastroscopic removal of a giant fibrovascular polyp from the esophagus.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 14 δευτερόλεπτα

*Gastroscopic removal of a giant fibrovascular polyp from the esophagus.* Thorac Cancer. 2016 Apr 26;7(3):363-6 Authors: Li J, Yu H, Pu R, Lu Z Abstract Giant polyps in the esophagus are rarely occurring benign tumors and may contain lipomas, fibrovascular polyps, fibrolipomas or neurofibromas polyps. Clinical symptoms include dysphagia, vomiting, retrosternal pain, shortness of breath, and asthma. In some cases, the polyps are regurgitated into the oral cavity and represent a spectacular manifestation. The reported case in this study was of a 50-year-old man who complained of em... περισσότερα »

Clinical features and prognosis in anti-SRP and anti-HMGCR necrotising myopathy.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 14 δευτερόλεπτα

*Clinical features and prognosis in anti-SRP and anti-HMGCR necrotising myopathy.* J Neurol Neurosurg Psychiatry. 2016 May 4; Authors: Watanabe Y, Uruha A, Suzuki S, Nakahara J, Hamanaka K, Takayama K, Suzuki N, Nishino I Abstract OBJECTIVE: To elucidate the common and distinct clinical features of immune-mediated necrotising myopathy (IMNM), also known as necrotising autoimmune myopathy associated with autoantibodies against signal recognition particle (SRP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). METHODS: We examined a cohort of 460 patients with idiopathic... περισσότερα »

A Preliminary Study of How the Viscosity of Dietary Fluids and Videofluoroscopy Fluids can be Matched.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 14 δευτερόλεπτα

*A Preliminary Study of How the Viscosity of Dietary Fluids and Videofluoroscopy Fluids can be Matched.* Dysphagia. 2016 May 5; Authors: Suzuki H, Kondo I, Sakamoto K, Kimura K, Matsumoto T Abstract This study examined the method by which the viscosity of mealtime and videofluoroscopy fluid can be matched through adjustment of the amount of xanthan gum-based thickener added to them. Viscosity measurement was made with a cone-plate viscometer. Samples were tested at 5, 25, 45, and 65 ± 0.1 °C and shear rates of 5-200 s(-1). We found that the adjusted amount of thickener differs de...περισσότερα »

[Transthoracic myotomy of a case of giant megaesophagus in Mali hospital].

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 14 δευτερόλεπτα

[image: http:--http://ift.tt/1MOzwGw] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *[Transthoracic myotomy of a case of giant megaesophagus in Mali hospital].* Pan Afr Med J. 2015;21:239 Authors: Togo S, Abdoulaye OM, Xing L, Sadio Y PMID: 26523179 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1rxUNBM via IFTTT

Randomised clinical trial: transoral incisionless fundoplication vs. sham intervention to control chronic GERD.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 14 δευτερόλεπτα

Delayed hypersensitivity reaction after cervical disc replacement: a case report.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 14 δευτερόλεπτα

The Causal Relationship Between Income and Health

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Invited Commentary: Using Financial Credits as Instrumental Variables for Estimating the Causal Relationship Between Income and Health: Social epidemiologists are interested in determining the causal relationship between income and health. Natural experiments in which individuals or groups receive income randomly or quasi-randomly from financial credits (e.g., tax credits or cash transfers) are increasingly being analyzed using instrumental variable analysis. For example, in this issue of the *Journal*, Hamad and Rehkopf (*Am J Epidemiol*. 2016;183(9):775–784) used an in-work tax c... περισσότερα »

Poverty and Child Development

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

A Longitudinal Study of the Impact of the Earned Income Tax Credit: Although adverse socioeconomic conditions are correlated with worse child health and development, the effects of poverty-alleviation policies are less understood. We examined the associations of the Earned Income Tax Credit (EITC) on child development and used an instrumental variable approach to estimate the potential impacts of income. We used data from the US National Longitudinal Survey of Youth (*n* = 8,186) during 1986–2000 to examine effects on the Behavioral Problems Index (BPI) and Home Observation Measur...περισσότερα »

History of Severe Sunburn and Risk of Skin Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Among Women and Men in 2 Prospective Cohort Studies: Few studies have assessed the relationship between sunburn and risk of different skin cancers (melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC)) in prospective studies simultaneously, and little is known about the association of severe sunburns at different body sites with skin cancer risk. We used data on 87,166 women in the Nurses' Health Study (1982–2010) and 32,959 men in the Health Professionals Follow-up Study (1992–2010) to investigate skin cancer risk associated with history of severe sunburns at d...περισσότερα »

Incident Ischemic Heart Disease After Long-Term Occupational Exposure to Fine Particulate Matter

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Accounting for 2 Forms of Survivor Bias: Little is known about the heart disease risks associated with occupational, rather than traffic-related, exposure to particulate matter with aerodynamic diameter of 2.5 µm or less (PM2.5). We examined long-term exposure to PM2.5 in cohorts of aluminum smelters and fabrication workers in the United States who were followed for incident ischemic heart disease from 1998 to 2012, and we addressed 2 forms of survivor bias. Left truncation bias was addressed by restricting analyses to the subcohort hired after the start of follow up. Healthy work... περισσότερα »

Statins for Breast Cancer Prevention

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Statins for Breast Cancer Prevention: Statins have the potential to reduce breast cancer incidence and recurrence as shown in both epidemiologic and laboratory studies. The purpose of this study was to evaluate the effect of a lipophilic statin, atorvastatin, on breast cancer biomarkers of risk [mammographic density (MD) and insulin growth factor 1 (IGF-1)] in high-risk premenopausal women. Premenopausal women at increased risk for breast cancer received either 40 mg of atorvastatin or placebo for 1 year. Biomarker assessment was performed prior to initiation and at completion of s... περισσότερα »

The tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Clinical Trial of 2-Phenethyl Isothiocyanate: 2-Phenethyl isothiocyanate (PEITC), a natural product found as a conjugate in watercress and other cruciferous vegetables, is an inhibitor of the metabolic activation and lung carcinogenicity of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in F344 rats and A/J mice. We carried out a clinical trial to determine whether PEITC also inhibits the metabolic activation of NNK in smokers. Cigarette smokers were recruited and asked to smoke cigarettes containing deuterium-labeled [pyridine-D4]NNK for an acclimation... περισσότερα »

Neuromuscular electrical stimulation improves radiation-induced fibrosis through Tgf-Β1/MyoD homeostasis in head and neck cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Neuromuscular electrical stimulation improves radiation-induced fibrosis through Tgf-Β1/MyoD homeostasis in head and neck cancer: Objectives The purpose of this study was to analyze TGF-β1 and MyoD expression in cervical muscles during radiation therapy (RT) and their role in inducing muscle fibrosis in head and neck cancer (HNC) patients. We also studied the effect of combined traditional swallow therapy (TST) and neuromuscular electrical stimulation (NMES) therapy on TGF-β1/MyoD homeostasis in patients undergoing post-operative RT for HNC. Study Design Case–control study. Methods ...περισσότερα »

Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials): AbstractMuscle wasting in cancer is a common and often occult condition that can occur prior to overt signs of weight loss and before a clinical diagnosis of cachexia can be made. Muscle wasting in cancer is an important and independent predictor of progressive functional impairment, decreased quality of life, and increased mortality. Although several therapeutic agents ar... περισσότερα »

Immunohistochemical Study EMT-Related Proteins in HPV-, and EBV-Negative Patients with Sinonasal Tumours

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Immunohistochemical Study EMT-Related Proteins in HPV-, and EBV-Negative Patients with Sinonasal Tumours: AbstractEpithelial to mesenchymal transition (EMT) is a biological process in which the epithelial cells, transform to mesenchymal cells via multiple biochemical modifications. Immunohistochemical method was used to examine the expression of EMT-related proteins: Slug, E-cadherin and fibronectin, in 41 cases of sinonasal inverted papilloma (SIP), 33 cases of sinonasal squamous cell carcinoma (SNC), and 22 cases of normal mucosa as a control. In all cases negative viral status w... περισσότερα »

Lead identification for the K-Ras protein

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Lead identification for the K-Ras protein: Akbar Ali Khan Pathan,1,2,* Bhavana Panthi,3,* Zahid Khan,1 Purushotham Reddy Koppula,4–6Mohammed Saud Alanazi,1 Sachchidanand,3 Narasimha Reddy Parine,1 Mukesh Chourasia3,* 1Genome Research Chair (GRC), Department of Biochemistry, College of Science, King Saud University, 2Integrated Gulf Biosystems, Riyadh, Kingdom of Saudi Arabia; 3Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, Hajipur, India;4Department of Internal Medicine, School of Medicine, 5Harry S. Truman Memorial Veterans Affairs... περισσότερα »

LDL-C levels and prognosis in nasopharyngeal carcinoma patients

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

LDL-C levels and prognosis in nasopharyngeal carcinoma patients: Qiu Tang, Qiao-Ying Hu, Yong-feng Piao, Yong-Hong Hua Department of Head and Neck Cancer Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People’s Republic of China *Purpose: *To investigate the correlations between long-term survival outcomes in patients with nasopharyngeal carcinoma (NPC) and pretreatment serum low-density lipoprotein cholesterol (LDL-C) levels. *Patients and methods: *Between January 2008 and December 2011, 935 patients with newly diagnosed NPC who were treated with intensity-modulated ... περισσότερα »

Drinking Water and Arsenic

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Elevated Bladder Cancer in Northern New England: The Role of Drinking Water and Arsenic: *Background:* Bladder cancer mortality rates have been elevated in northern New England for at least five decades. Incidence rates in Maine, New Hampshire, and Vermont are about 20% higher than the United States overall. We explored reasons for this excess, focusing on arsenic in drinking water from private wells, which are particularly prevalent in the region. *Methods:* In a population-based case-control study in these three states, 1213 bladder cancer case patients and 1418 control subjects ...περισσότερα »

Strategies to genetically engineer T cells for cancer immunotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Strategies to genetically engineer T cells for cancer immunotherapy: AbstractImmunotherapy is one of the most promising and innovative approaches to treat cancer, viral infections, and other immune-modulated diseases. Adoptive immunotherapy using gene-modified T cells is an exciting and rapidly evolving field. Exploiting knowledge of basic T cell biology and immune cell receptor function has fostered innovative approaches to modify immune cell function. Highly translatable clinical technologies have been developed to redirect T cell specificity by introducing designed receptors. Th... περισσότερα »

Utility of 18F-FDG-PET/CT in patients suspected of paraneoplastic neurological syndrome

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

: importance of risk classification: Abstract PurposeTo assess the diagnostic impact of 18F-FDG-PET/CT in patients suspected of paraneoplastic neurological syndrome (PNS) based on our own pre-test risk classification (PRC). MethodsA multicenter retrospective longitudinal study was conducted from 2006 to 2014. We designed a seven-point scoring system using the clinical syndrome characteristics [classical (CS) and non-classical syndromes (NCS)] and its location (central, peripheral, in the neuromuscular junction or combined), onconeural antibodies and tumor markers. Patients were...περισσότερα »

The gastrointestinal microbiome in infectious complications during induction chemotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

for acute myeloid leukemia: BACKGROUND Despite increasing data on the impact of the microbiome on cancer, the dynamics and role of the microbiome in infection during therapy for acute myelogenous leukemia (AML) are unknown. Therefore, the authors sought to determine correlations between microbiome composition and infectious outcomes in patients with AML who were receiving induction chemotherapy (IC). METHODS Buccal and fecal specimens (478 samples) were collected twice weekly from 34 patients with AML who were undergoing IC. Oral and stool microbiomes were characterized by 16S rib... περισσότερα »

Patients with early-stage esophageal adenocarcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Treatment allocation in patients with early-stage esophageal adenocarcinoma: Prevalence and predictors of lymph node involvement: BACKGROUND In considering treatment allocation for patients with early esophageal adenocarcinoma, the incidence of lymph node metastasis is a critical determinant; however, this has not been well defined or stratified by the relevant clinical predictors of lymph node spread. METHODS Data from the Surveillance, Epidemiology, and End Results database of the National Cancer Institute were abstracted from 2004 to 2010 for patients with early-stage esophageal ...περισσότερα »

Central nervous system embryonal tumours

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Incidence and survival of children and young people with central nervous system embryonal tumours in the North of England, 1990–2013 via ScienceDirect Publication: European Journal of Cancer Publication date: July 2016 *Source:*European Journal of Cancer, Volume 61 Author(s): L. Fairley, S.V. Picton, R.J.Q. McNally, S. Bailey, M.G. McCabe, R.G. Feltbower BackgroundMedulloblastoma and primitive neuroectodermal tumours (PNET) are the most common central nervous system (CNS) embryonal tumours diagnosed in childhood. Survival outcomes are worse for children diagnosed with CNS PNET compared... περισσότερα »