Toxins, Vol. 7, Pages 4381-4389: Quantitative Detection of Shiga Toxins Directly from Stool Specimens of Patients Associated with an Outbreak of Enterohemorrhagic Escherichia coli in Japan—Quantitative Shiga toxin detection from stool during EHEC outbreak
Detection of Shiga toxins (Stx) is important for accurate diagnosis of Enterohemorrhagic Escherichia coli infection. In this study, we quantitatively analyzed Stx protein in nine patients' stool during an outbreak that occurred in Japan. Highly sensitive immunoassay (bead enzyme-linked immunosorbent assay (bead-ELISA)) revealed that the concentrations of toxins in stool of patients ranged from 0.71 to 10.44 ng/mL for Stx1 and 2.75 to 51.61 ng/mL for Stx2. To our knowledge, this is the first report that reveals the range of Stx protein concentrations in human stools. from #Medicin... περισσότερα »
Direct Measurement of Trace Elemental Mercury in Hydrocarbon Matrices by Gas Chromatography with Ultraviolet Photometric Detection
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b02895 [image: ancham?d=yIl2AUoC8zA] from #Medicine via ola Kala on Inoreader http://ift.tt/1WgA25G via IFTTT
Cesium Speciation in Dust from Municipal Solid Waste and Sewage Sludge Incineration by Synchrotron Radiation Micro-X-ray Analysis
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b03298 [image: ancham?d=yIl2AUoC8zA] from #Medicine via ola Kala on Inoreader http://ift.tt/1M0apoi via IFTTT
Societies, Vol. 5, Pages 713-733: The Domains of Organizational Learning Practices: An Agency-Structure Perspective
Background: Organizational learning theory has retained considerable attention in the past decades from a wide array of academic disciplines in social sciences. Yet few integrative efforts have satisfactorily offered a comprehensive and systematic articulation of the concept of organizational learning with regards to: (a) its core constitutive dimensions and associated mechanisms; (b) the analytical levels from such mechanisms operate (e.g., workers, teams, organizations); as well as (c) their interplay. Methods: This article builds on a critical synthesis of predominant approache... περισσότερα »
Polymers, Vol. 7, Pages 2165-2174: Biodegradable Shape Memory Polymeric Material from Epoxidized Soybean Oil and Polycaprolactone
This article deals with the synthesis of plant oil-based shape memory materials from epoxidized soybean oil (ESO) and polycaprolactone (PCL). PolyESO/PCLs were synthesized by an acid-catalyzed curing in the presence of PCL. During the reaction, PCL scarcely reacted with ESO and the crystallinity of the PCL component decreased to form a semi-interpenetrating network structure. The incorporation of the PCL components improved the maximum stress and strain at break of ESO-based network polymer. The polyESO/PCL was gradually degraded by Pseudomonas cepasia lipase. Furthermore, the pol... περισσότερα »
Viruses, Vol. 7, Pages 5632-5642: Identification and Application of Neutralizing Epitopes of Human Adenovirus Type 55 Hexon Protein
Human adenovirus type 55 (HAdV55) is a newly identified re-emergent acute respiratory disease (ARD) pathogen with a proposed recombination of hexon gene between HAdV11 and HAdV14 strains. The identification of the neutralizing epitopes is important for the surveillance and vaccine development against HAdV55 infection. In this study, four type-specific epitope peptides of HAdV55 hexon protein, A55R1 (residues 138 to 152), A55R2 (residues 179 to 187), A55R4 (residues 247 to 259) and A55R7 (residues 429 to 443), were predicted by multiple sequence alignment and homology modeling meth...περισσότερα »
Viruses, Vol. 7, Pages 5619-5631: Exposure to West Nile Virus Increases Bacterial Diversity and Immune Gene Expression in Culex pipiens
Complex interactions between microbial residents of mosquitoes and arboviruses are likely to influence many aspects of vectorial capacity and could potentially have profound effects on patterns of arbovirus transmission. Such interactions have not been well studied for West Nile virus (WNV; Flaviviridae, Flavivirus) and Culex spp. mosquitoes. We utilized next-generation sequencing of 16S ribosomal RNA bacterial genes derived from Culex pipiens Linnaeus following WNV exposure and/or infection and compared bacterial populations and broad immune responses to unexposed mosquitoes. Our...περισσότερα »
Technologies, Vol. 3, Pages 219-237: A New Compton Camera Imaging Model to Mitigate the Finite Spatial Resolution of Detectors and New Camera Designs for Implementation
An intrinsic limitation of the accuracy that can be achieved with Compton cameras results from the inevitable fact that the detectors, which comprise the camera, cannot have infinitely-accurate spatial resolution. To mitigate this loss of accuracy, a new imaging model is proposed. The implementation of the new imaging model, however, requires new camera designs. The results of a computer simulation indicate that the new imaging model can produce reasonable images, at least when noiseless simulated data are used. In the future, more work is needed to determine if the use of the new ... περισσότερα »
Knowledge seeking behaviours of pre interns and early career doctors in Sri Lanka: a cross sectional study
Background: Use of reference sources for medical knowledge has changed dramatically over the last two decades with the introduction of online sources of information. This study analyses the medical knowledge seeking behaviours of pre interns and early career doctors in Sri Lanka. Methods: This cross sectional survey with a convenience sample was conducted at two sites targeting two groups; pre-intern doctors graduated from the Faculty of Medicine, University of Colombo and early career doctors following a postgraduate course at the National Hospital of Sri Lanka. The data collecti... περισσότερα »
Materials, Vol. 8, Pages 7230-7240: The Effects of Zr Doping on the Optical, Electrical and Microstructural Properties of Thin ZnO Films Deposited by Atomic Layer Deposition
Transparent conducting oxides (TCOs), with high optical transparency (≥85%) and low electrical resistivity (10−4 Ω·cm) are used in a wide variety of commercial devices. There is growing interest in replacing conventional TCOs such as indium tin oxide with lower cost, earth abundant materials. In the current study, we dope Zr into thin ZnO films grown by atomic layer deposition (ALD) to target properties of an efficient TCO. The effects of doping (0–10 at.% Zr) were investigated for ~100 nm thick films and the effect of thickness on the properties was investigated for 50–250 nm thic... περισσότερα »
Materials, Vol. 8, Pages 7217-7229: Active Nanofibrous Membrane Effects on Gingival Cell Inflammatory Response
Alpha-melanocyte stimulating hormone (α-MSH) is involved in normal skin wound healing and also has anti-inflammatory properties. The association of α-MSH to polyelectrolyte layers with various supports has been shown to improve these anti-inflammatory properties. This study aimed to evaluate the effects of nanofibrous membrane functionalized with α-MSH linked to polyelectrolyte layers on gingival cell inflammatory response. Human oral epithelial cells (EC) and fibroblasts (FB) were cultured on plastic or electrospun Poly-#-caprolactone (PCL) membranes with α-MSH covalently coupled... περισσότερα »
Resources, Vol. 4, Pages 787-795: Taylor Law in Wind Energy Data
The Taylor power law (or temporal fluctuation scaling), is a scaling relationship of the form σ ~ (P)λ where !! is the standard deviation and hPi the mean value of a sample of a time series has been observed for power output data sampled at 5 min and 1 s and from five wind farms and a single wind turbine, located at different places. Furthermore, an analogy with the turbulence field is performed, consequently allowing the establishment of a scaling relationship between the turbulent production IP and the mean value (P). from #Medicine via ola Kala on Inoreader http://ift.tt/1P2Ud... περισσότερα »
Nutrients, Vol. 7, Pages 8871-8886: Real Time Monitoring of Inhibition of Adipogenesis and Angiogenesis by (−)-Epigallocatechin-3-Gallate in 3T3-L1 Adipocytes and Human Umbilical Vein Endothelial Cells
Little is known about the effect of (−)-epigallocatechin-3-gallate (EGCG) on angiogenesis in adipocytes. We aimed to test the effect of EGCG on the expression of vascular endothelial growth factor (VEGF) in adipocytes. The levels of VEGF secretion, the expression of VEGF message ribonucleic acid (mRNA) and VEGF protein in 3T3-L1 cells were measured by enzyme linked immunosorbent assay (ELISA), real time polymerase chain reaction (PCR), and immunofluorescence staining, respectively. The xCELLigence real time cell analysis system was used to study the growth and differentiation of 3T... περισσότερα »
Pleomorphic adenoma involving soft tissue overlying the anterior border of ramus of the mandible: A rare ectopic presentation
Publication date: Available online 26 October 2015 *Source:*Journal of Oral Biology and Craniofacial Research Author(s): Naresh Kumar Sharma, Akhilesh Kumar Singh, Arun Pandey, Vishal Verma Ectopic pleomorphic adenoma is a rare presentation in sites other than major and minor salivary glands. In literature, cases of pleomorphic adenoma in the soft tissue of the neck, skin of the external auditory canal, subcutaneous layer of nose, and lymph node of mediastinum have been reported. We report a case of ectopic pleomorphic adenoma localized in the soft tissue over the anterior border of...περισσότερα »
Varian’s VitalBeam Cost-Conscious Radiotherapy System Unveiled
[image: Varian-VitalBeam]*Varian* has released its new VitalBeam radiotherapy system following both FDA and CE Mark approvals. The device is a budget option over the firm's TrueBeam system, but includes many of the features found in the more advanced sibling. VitalBeam is designed to be modular, allowing clinics to add and combine new capabilities such as kV, MV, Cone-beam CT (CBCT), and fluoro imaging, configurable photon and electron energies, IMRT, RapidArc, High Intensity Mode, and intra-fraction motion review. Product page: Varian VitalBeam… Source: Varian Medical Systems… ...περισσότερα »
Journal of Antibiotics
EDITORIALTopObituary: Remembering Emeritus Professor Lester Mitscher (20 August 1931–8 May 2015) James (Jim) McAlpine J Antibiot 2015 68: 601-602; 10.1038/ja.2015.75 Full Text ORIGINAL ARTICLESTopInduced sclerotium formation exposes new bioactive metabolites from *Aspergillus sclerotiicarbonarius* Lene M Petersen, Jens C Frisvad, Peter B Knudsen, Marko Rohlfs, Charlotte H Gotfredsen and Thomas O Larsen J Antibiot 2015 68: 603-608; advance online publication, May 6, 2015; 10.1038/ja.2015.40 Abstract | Full Text Dibenzocyclooctadiene lignans from *Schisandra* spp. selectively inhibit the... περισσότερα »
Journal of Clinical Neurosurgery
Ultra early microsurgical treatment for anterior communicating artery aneurysm of high-grade combined intraventricular hemorrhage (合并脑室出血的高级别前交通动脉瘤的超早期显微手术治疗) ZUO Kui, ,ZHU Zuo, ,HUANG Xin, ,YU Renxi, ,GUO Guangliang, ,WANG Jinpeng, ,PENG Zhixiang ...... page:321-323,327 Clinical comparative study on CTA and DSA in diagnosis and operative evaluation of intracranial aneurysm (CTA 与 DSA 在颅内动脉瘤诊断及手术评估中的临床比较研究) ZONG Zhenkun, ,YU Rutong, ,FAN Yuechao, ,LIU Yong ...... page:324-327 Correlation between complications and prognosis of clipping of intracranial aneurysms and its relevant fac... περισσότερα »
GALNT7, a target of miR-494, participates in the oncogenesis of nasopharyngeal carcinoma
Abstract GalNAc-transferase-7 (GALNT7) is essential for the regulation of cell proliferation and has been implicated in tumorigenesis. However, the role of GALNT7 in the development and progression of nasopharyngeal carcinoma (NPC) remains unclear. Our previous study showed that GALNT7 was a putative target of miR-494, which was confirmed by luciferase reporter assay. In the present study, we demonstrated that in vitro knockdown of GALNT7 significantly inhibited the proliferation, colony formation, migration, and invasion of NPC-derived cells. In vivo tumorigenicity assay showed th...περισσότερα »
Increased expression of interleukin-8 is an independent indicator of poor prognosis in clear-cell renal cell carcinoma
Abstract On the basis of aberrant interleukin-8 (IL-8) expression, a crucial angiogenesis factor and potential therapeutic target, in clear-cell renal cell carcinoma (ccRCC), this study aims to assess the prognostic significance of IL-8 in ccRCC. This retrospective study enrolled 271 patients who underwent nephrectomy for ccRCC in a single institution. The associations of IL-8 expression with clinical and pathological features were assessed using chi-squared tests. The impact on cancer-specific survival (CSS) and relapse-free survival (RFS) was analyzed using univariable and multi... περισσότερα »
Expression of cholecystokinin receptors in colon cancer and the clinical correlation in Taiwan
Abstract Cholecystokinin and gastrin receptors are upregulated in many human digestive malignancies; however, the correlation of their expressions with severity of colon carcinoma remains sketchy. Here, we determined the expression of cholecystokinin-1 and cholecystokinin-2 receptor, CCK1R and CCK2R, in colon carcinomas and investigated their correlations with clinicopathological characteristics and 1-year survival rate. Expression of CCK1R and CCK2R was determined by immunohistochemical assay in tissue samples obtained from 97 surgical specimens. Clinicopathological character ana... περισσότερα »
CXCL5 is a potential diagnostic and prognostic marker for bladder cancer patients
Abstract Chemokine C-X-C motif ligand 5 (CXCL5) is critical for bladder cancer growth and progression. Our previous study demonstrated that increase of CXCL5 in bladder cancer cell lines had an effect on tumor growth and progression. This study aims to investigate the expression of CXCL5 in tissue and urine of bladder cancer patients, in relation to clinicopathologic parameters, and as a predictive value in diagnosing and evaluating bladder cancer. Urothelial bladder cancer tissues from 255 patients were profiled for CXCL5 alterations by immunohistochemistry. Urine samples collect... περισσότερα »
Novel MicroRNA signatures in HPV-mediated cervical carcinogenesis in Indian women
Abstract This study aimed to investigate the role of miRNAs in HPV-mediated cervical pre-cancer and cancer cases in Indian population. We analysed the HPV infection and its genotypes in uterine cervical pre-cancer (*n* = 80), cancer (*n* = 200) and normal cervical samples (*n* = 150) by consensus sequence PCR followed by type specific PCRs. Also, microRNA profiling was done in a subset of cervical pre-cancer (*n* = 20), cancer cases (*n* = 50) and normal samples (*n* = 30) by real-time quantitative PCR (qRT-PCR). The prevalence of HPV infection in pre-cancer was found to be 81 % (6...περισσότερα »
The c.*229C > T gene polymorphism in 3′UTR region of the topoisomerase IIβ binding protein 1 gene and LOH in BRCA1/2 regions and their effect on the risk and progression of human laryngeal carcinoma
Abstract Topoisomerase IIβ binding protein 1 (TopBP1), a multiple-BRCT-domain, protein plays crucial roles in chromosome replication, DNA damage repair, apoptosis, and cell cycle checkpoint signalling. The aim of this study was to identify five SNPs at loci potentially located in the 3′UTR region of the *TopBP1* gene (rs185903567, rs116645643, rs115160714, rs116195487, rs112843513), their relationship with the risk of squamous cell laryngeal cancer (SCLC), tumor invasiveness, and prognosis. Genotyping was performed in 323 genetically unrelated individuals with SCLC and 418 randomly...περισσότερα »
SATB2 suppresses gastric cancer cell proliferation and migration
Abstract Gastric cancer is one of the death-related malignant tumors worldwide. It remains a challenge for the diagnosis and treatment of gastric cancer. Special AT-rich sequence-binding protein 2 (SATB2) is a new tumor suppressive gene and plays important roles in many cancers. However, the role of SATB2 in gastric cancer is still unknown. In the present study, we demonstrated that downregulation of SATB2 was associated with shortened survival in patients with gastric cancer. Ectopic expression of SATB2 inhibited gastric cancer cell proliferation, colony formation, and migration.... περισσότερα »
CCL15/CCR1 axis is involved in hepatocellular carcinoma cells migration and invasion
Abstract The identification of new biomarkers for the early detection of hepatocellular carcinoma is critical in the development of tumor-targeted therapy, which is possibly advantageous on the prognosis of this disease. Results from our previous study indicated that CCL15 can be a specific proteomic biomarker of hepatocellular carcinoma, which plays an important role in tumorigenesis and tumor invasion. In this study, we found that CCL15 can induce hepatocellular carcinoma cell migration and invasion. Furthermore, CCR1, the receptor of CCL15, was demonstrated to play a critical r... περισσότερα »
NFATC1 promotes cell growth and tumorigenesis in ovarian cancer up-regulating c-Myc through ERK1/2/p38 MAPK signal pathway
Abstract It has been reported that nuclear factor of activated T cells (NFATC1) was up-regulated in cancers mediating malignant behaviors. However, the role of NFATC1 in ovarian cancer has not been elucidated. In the present study, we undertook to explore the clinicopathological significance of NFATC1 expression and the mechanism by which NFATC1 works in ovarian cancer. Expression status of NFATC1 was examined using immunohistochemistry. Both knockdown and re-expression of NFATC1 on ovarian cancer cells were employed to observe the effect overgrowth. It was found that NFATC1 was s... περισσότερα »
Knockdown of miR-221 promotes the cisplatin-inducing apoptosis by targeting the BIM-Bax/Bak axis in breast cancer
Abstract Accumulating evidence shows that microRNAs (miRNAs) have a critical role in the initiation and progression of types of human cancer, including breast cancer. Recent research indicated that miRNAs are also related with the chemotherapy on cancers. In this study, the expression of miR-221 in breast cancer (BC) patients' serum and cancer tissues was found to be significantly up-regulated. The results of in vitro MTT assay indicated that although the anti-miR-221 oligonucleotide alone did not influence the viability of BC cell lines markedly, it significantly promoted the cyt... περισσότερα »
Submission Bias and the Rise of Open Access Journals
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External Rhinoplasty by Skin Excision to Correct Hypertrophic Tip of an Elderly Patient
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Thoughts on "Commentary on Labia Minora Reduction Techniques: A Comprehensive Literature Review"
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Nationwide Incidence, Cost, and Epidemiologic Trends in Facial Rhytidectomy: An Examination of Inpatient Facelifts Using the Nationwide Inpatient Sample (NIS) Database
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Response to "Does Lower Extremity Elevation Reduce Thromboembolism Risk After Abdominoplasty?"
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Comments on "Ten-Year Results From the Natrelle 410 Anatomical Form-Stable Silicone Breast Implant Core Study" and its Assigned Level of Evidence
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Oncoplastic and Reconstructive Breast Surgery
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Evaluation of the Effects of Silicone Implants on the Breast Parenchyma
Background Despite being the cosmetic procedure most performed worldwide, there are still few objective measurements of postoperative volumetric analysis of breast augmentation available in the literature. Objective The aim of this study was to evaluate volumetric changes in the breast parenchyma after the placement of silicone implants in the subglandular plane. Methods Thirty-four women were randomly allocated to the intervention group (n = 24), who underwent breast augmentation in the subglandular plane, or to the control group (n = 10), who received no intervention. Volume... περισσότερα »
Commentary on: Evaluation of the Effects of Silicone Implants on the Breast Parenchyma
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Commentary on: Transaxillary Endoscopic Breast Augmentation With Shaped Gel Implants
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Commentary on: Use of Nape and Peri-Auricular Hair by Follicular Unit Extraction to Create Soft Hairlines and Temples: My Experience with 128 Patients
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Commentary on: Safety of Vertical Augmentation-Mastopexy: Prospective Evaluation of Breast Perfusion Using Laser Fluorescence Imaging
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Enriched Autologous Facial Fat Grafts in Aesthetic Surgery: 3D Volumetric Results
Background Improved results with aesthetic fat augmentation of the face have been recently described by the concomitant use of autologous stem cells from the stromal vascular fraction (SVF). Objective There are no studies in the literature regarding facial fat augmentation results with the use of SVF using 3D computer volumetric analyses. This prospective study was thus undertaken to answer this question. Methods Fat was harvested by a standard liposuction technique for reinjection. A 50 cc aliquot of fat was also processed to obtain the SVF using a standard collagenase techni... περισσότερα »
Influence of Repeated Aspiration on Viability of Fat Grafts: A Comparative Study
Background Fat grafting has been increasingly widely used in cosmetic and reconstructive surgery. However, the long-term retention of fat grafts is still unpredictable. Many critical variables have been found to significantly affect the viability of fat grafts; still, some of the ordinary impact factors are overlooked. Objectives We performed this study to find out whether repeated aspiration had an impact on fat grafts through an *in vitro* analysis and a nude mouse model. Methods A 15 cm by 10 cm rectangle was marked at the lower abdomen. The cannula was gently advanced and ... περισσότερα »
The Alar Rim Flap: A Novel Technique to Manage Malpositioned Lateral Crura
Background Alar cartilage malposition is a common anatomic variation in which the axis of the lateral crus lies cephalically and may be parallel to the cephalic septum. Malposition of the lateral crura may produce inward collapse of the alae that is observable on deep inspiration. Objectives The authors performed the alar rim flap technique to treat patients with alar malposition and assessed functional and aesthetic outcomes. Methods Twelve patients who underwent primary open rhinoplasty with the alar rim flap technique were evaluated in a prospective study. A 2- or 3-mm cauda... περισσότερα »
Safety of Vertical Augmentation-Mastopexy: Prospective Evaluation of Breast Perfusion Using Laser Fluorescence Imaging
Background Augmentation-mastopexy is often recommended to simultaneously correct breast ptosis and restore upper pole fullness. However, some investigators believe that this procedural combination increases risk and recommend staging the surgery for some patients. Objectives This prospective study was undertaken to evaluate the blood supply of the breast and, specifically, the nipples and areolae to determine whether breast implants inserted at the time of a vertical mastopexy compromise blood supply. Methods The SPY Elite Intraoperative Perfusion Assessment System was used to...περισσότερα »
Journal of International Oncology
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 38 δευτερόλεπτα
Sorafenib inhibits tumor growth through modulating vasculogenic mimicry in a hepatocellular carci-noma xenograft model (索拉非尼抑制人肝癌裸鼠皮下移植瘤血管生成拟态作用研究) Zhang Yueying, ,Wang Zhaopeng, ,Wang Zhaoxia, ,Jia Qing, ,Wang Hengxiao, ,Jiang Guosheng, ,Zhang Weidong ...... page:721-725 Therapeutic effect and prognostic factors for patients with mucoepidermoid carcinoma of parotid gland (腮腺黏液表皮样癌单纯手术和术后辅助放化疗疗效和预后因素分析) Wei Cunzhi, ,Cai Defeng, ,Qu Jinwen, ,Xiao Shiqiang, ,Wang Jianhong ...... page:726-729 Expressions of MMP-7 and bFGF and their correlations with tumor interstitial microvascular de... περισσότερα »
The GABAB receptor agonist, baclofen, contributes to three distinct varieties of amnesia in the human brain
Publication date: Available online 26 October 2015 *Source:*Cortex Author(s): Adam Zeman, Serge Hoefeijzers, Fraser Milton, Michaela Dewar, Melanie Carr, Claire Streatfield We describe a patient in whom long-term, therapeutic infusion of the selective gamma-amino-butyric acid type B (GABAB) receptor agonist, baclofen, into the cerebrospinal fluid gave rise to three distinct varieties of memory impairment: i) repeated, short periods of severe global amnesia, ii) accelerated long-term forgetting, evident over intervals of days and iii) a loss of established autobiographical memories. ... περισσότερα »
Journal of Practical Stomatology
Adhesion,proliferation and ALP activity of osteoblasts on porous Ti processed by laser solid forming (成骨细胞在激光立体成形多孔钛表面的附着、增殖及 ALP 活性) LIU Zhiyong, ,MU Yaxing, ,YANG Haiou, ,GAO Bo, ,LIN Xin ...... page:603-606 Comparative study on the compressive strength of porcelain crown with different base materials (不同基底材料烤瓷冠抗压缩破坏力的对比研究) WU Jie, ,CHEN Zhiyu, ,QIU Yafei, ,LI Ning, ,GUO Changjun ...... page:607-610 Reliability of flexural strength and subcritical crack growth of two kinds of zirconia ceramics (2种牙科氧化锆陶瓷材料的弯曲强度可靠性和亚临界裂纹扩展研究) GONG Xu, ,ZHAO Xinyi, ,ZHANG Chunbao, ,LI Shibao, ,SHEN ... περισσότερα »
Chinese Journal of Orthodontics
gic drift of lower incisors in different vertical skeletal patterns (不同垂直骨面型下切牙生理性调整的临床研究) Lu Xinhua, ,Wu Liping, ,Xu Yue, ,Xie Yongjian, ,Cai Bin ...... page:121-126 The comparison of effects in different extraction patterns treated with Alexander discipline (亚历山大矫治技术两种拔牙模式矫治差异的研究) Liu Fuliang, ,Wen Fujia, ,Wei Song, ,Liu Weitao, ,Zhou Yanheng ...... page:127-131 An retrospective study of soft tissue changes of lip and chin morphology in skeletal Class Ⅲ adult patients with orthognathic surgery (成人骨性Ⅲ类手术患者唇颏部软组织形态改变的回顾性研究) Yang Yifan, ,Liang yuan, ,Wang Yali, ,Ding Yin ...... page... περισσότερα »
Chinese Journal of Clinical and Experimental Pathology
Study of MK promoting breast cancer cell MDA-MB-231 angiogenesis through EPCR/PAR1 pathway in vitro (MK 通过 EPCR/PAR1通路促进乳腺癌 MDA-MB-231细胞体外血管生成) WANG Qing-ling, ,LIU Dong-mei, ,HAN Zheng-jie, ,WU Yong-ping ...... page:961-965 Enrichment of breast cancer stem cells by serum-free culture (无血清培养有效富集乳腺癌干细胞) YIN Yan-xue, ,LI Chuan-wei, ,YU Ai-lian, ,WANG Xue-chun ...... page:966-970 Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities (成人IDH野生型星形细胞瘤从生物学和临床上归为其他肿瘤类型) David E R,Annekathrin K, ,Felix S ...... page:970-970 Clinicopathologic analysis... περισσότερα »
Journal of Clinical Electroneurophysiology
A survey of sleep condition in patients with pure sleep-related epilepsy (睡眠期癫(痫)患者的睡眠状况调查) FANG Youzuo, ,LUO Zuowen, ,ZHU Guoxing, ,LI Beizuo, ,WU Zuoying, ,DING Zuo, ,HONG Zhen ...... page:193-196,221 Clinical experience of 121 cases of epilepsy with comprehensive treatment (121例癫(痫)综合治疗的临床体会) LV Ying, ,LIU Jian, ,YANG Hua, ,XIANG Xin, ,XU Xueyou, ,PENG Zuo ...... page:197-202 zai yi you guan nao dian tu miao shu zhong shui mian fen qi de wen ti (再议有关脑电图描述中睡眠分期的问题) ZHANG Wenyuan ...... page:202 The study of after-discharges(AD) caused by electrical cortical stimulation (颅内电极皮层... περισσότερα »
Chinese Journal of Emergency Medicine
Features of survived casualties and treatment strategies in Kunshan "August 2" explosion aaccident (昆山"8·2"爆炸事故存活伤员损伤特点及救治分析) LIU Jun, ,ZHAO Fuli, ,WU Jian, ,WU Shuhua, ,YANG Aixiang, ,LI Xiaoying, ,PENG Xiao, ,CHANG Xin, ,CHENG Hongyu ...... page:952-957 The protective effect of hydrogen-rich saline on lung injury associated with severe acute pancreatitis and its impact on P38MAPK and NF-κB expression (氢饱和生理盐水对重症急性胰腺炎大鼠肺损伤的保护作用及对P38MAPK和NF-κB表达的影响) Fan Bin, ,Shi Qiao, ,Liu Liming, ,Wang Weixing ...... page:964-968 Protective effect of bradykynin postconditioning on neurons in rat... περισσότερα »
Bulletin of the Academy of Military Medical Sciences
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
Design and research of intelligent system for triage (智能检伤分类系统的设计与研究) WANG Dan, ,ZHANG Guang, ,CHEN Feng, ,SONG Zhen-xing, ,WANG Hai-tao, ,LU Heng-zhi,,WANG Ya-lin, ,WU Tai-hu ...... page:651-655 yi xue ming ci shu yu shi yong gui fan (医学名词术语使用规范) BEN Kanbianjibu ...... page:655-655 Design of monitoring system for physiological parameters of a crew (乘员生理参数监测系统设计) WAN Hong, ,WANG Yan-qi, ,KAO Xin-bin, ,YAN Jin-hai, ,LUO Si-yuan ...... page:656-659 Purification of carbon monoxide in armored vehicle cabins (装甲车辆舱室内一氧化碳气体净化实验研究) WANG Xue-you, ,YANG Zhi, ,ZHANG Wei, ,ZHANG Xiang-li, ,C... περισσότερα »
International Review of Ophthalmology
Overview for power adjustable intraocular lens (可调屈光力的人工晶状体) CHEN Qian-yin, ,LIN Zhen-de ...... page:217-223 Progress in fundus imaging: confocal scanning laser opthalmoscope (眼底成像技术新进展——共聚焦激光扫描检眼镜) HUO Yan-jiao, ,WEI Wen-bin ...... page:224-228 Interferon associated ophthalmologic complications (干扰素相关性眼病) DU Kui-fang, ,GUO Chun-gang ...... page:229-233 Action mechanism of mitochondrial dysfunction and oxidative stress on trabecular meshwork cell injury (线粒体功能失调和氧化应激在小梁网细胞损伤中的作用机制) SUN Rui-zhu, ,ZHANG Shao-dan, ,LIANG Yuan-bo, ,LV Fan ...... page:234-238 Progress in research of o... περισσότερα »
International Journal of Immunology
Establishment of a high efficient expression system of a novol human monoclonal antibody against tumour necrosis factor-related apoptosis-inducing ligand receptor and its functional characteristics (全人源抗人肿瘤坏死因子相关诱导凋亡配体受体单克隆抗体蛋白高效表达体系的建立及其功能性分析) SHI Jianing, ,HAN Xiaojian, ,LYU Fulian, ,BI Dongmei, ,JIN Aishun ...... page:403-408 The study of the role of macrophages in atherosclerosis based on the co-expression network (基于共表达网络研究巨噬细胞在动脉硬化中的作用) ZHAO Hongqun, ,ZHANG Yiye, ,LI Wan, ,HE Yuehan, ,LYU Junjie, ,HUANG Hao, ,CHEN Lina ...... page:409-412 Purification of early pregnancy fact... περισσότερα »
IBM and Carneggie Mellon Releasing NavCog App for Blind People
[image: cmu-for-blind] [image: sensor] Example of a Bluetooth beacon attached to an 'exit' sign. A collaboration between IBM Research and Carnegie Mellon University has unveiled an open development platform to help programmers create apps for blind people. To demonstrate the capabilities of the platform they wrote the NavCog app that harnesses Bluetooth beacons placed around the university campus and the phone's own sensors to provide all sort of information about the nearby environment. The team is working on integrating more advanced capabilities that would let the app recogniz...περισσότερα »
Image anatomy of nasal septal swell body
Image anatomy of nasal septal swell body *Author(s):* ZHU Hangjun, ZHANG Jiandong, WANG Yuhai *Pages:* 463-464 *Year:* 2015 *Issue:* 9 *Journal:* *Chinese Archiver of Otolaryngology-Head and Neck Surgery* *Keyword:* Nasal Septum; Airway Resistance; Tomography; X-Ray Computed; Anatomy; nasal septal swell body; *Abstract:* [ABSTRACT]OBJECTIVETo investigate the clinic significance of nasal septal swell body by observing and measuring it in the normal and deviated nasal septum on CT images.METHODSThe locations of the nasal septal swell bodies on horizontal CT images in 50 normal subjects... περισσότερα »
Facial nerve hemangioma
Diagnosis and treatment of *Author(s):* GUO Liangrong, LI Jiandong *Pages:* 455-458 *Year:* 2015 *Issue:* 9 *Journal:* *Chinese Archiver of Otolaryngology-Head and Neck Surgery* *Keyword:* Facial Nerve Diseases; Hemangioma; Tomography; X-Ray Computed; Temporal Bone; Magnetic Resonance Imaging; *Abstract:* [ABSTRACT]OBJECTIVETo study clinical features and imaging manifestations of facial nerve hemangioma. METHODSClinical data of 5 cases with facial nerve hemangioma, who were diagnosed and treated in facial lab of Beijing Shijitan hospital between January 2006 and December 2011, were ... περισσότερα »
Laryngopharyngeal reflux disease
Effect of acid-suppressive drugs on laryngeal contact granuloma *Author(s):* TIAN Shiyu, LI Jinrang *Pages:* 438-441 *Year:* 2015 *Issue:* 9 *Journal:* *Chinese Archiver of Otolaryngology-Head and Neck Surgery* *Keyword:* Granuloma; Laryngeal; Drug Therapy; proton pump inhibitor; acid suppression; *Abstract:* [ABSTRACT]OBJECTIVETo assess the efficacy of proton pump inhibitor (PPI) on the treatment for laryngeal contact granuloma.METHODSSixty seven patients with laryngeal contact granuloma who were diagnosed in our department from March 2010 to October 2014 were enrolled in this stud...περισσότερα »
Obstructive sleep apnea hypopnea syndrome & The anatomy of the basis nasi
Relationships between the characteristics of the anatomy of the basis nasi and the severity of obstructive sleep apnea hypopnea syndrome *Author(s):* TAN Junlong, YE Jingying, ZHANG Junbo, LI Yanru, CAO Xin, DONG Jiajia *Pages:* 470-473 *Year:* 2015 *Issue:* 9 *Journal:* *Chinese Archiver of Otolaryngology-Head and Neck Surgery* *Keyword:* Sleep Apnea; Obstructive; Tomography; X-Ray Computed; Airway Obstruction; Pharynx; basis nasi; *Abstract:* [ABSTRACT]OBJECTIVETo investigate the relationships between the characteristics of the upper airway anatomy, including the basis nasi, and t... περισσότερα »
The spread of drug-resistant pathogens, such as methicillin-resistant S. aureus strains (MRSA)
A novel mutation in the *vraS* gene of *Staphylococcus aureus* contributes to reduce susceptibility against daptomycin Jie Su, Maki Iehara, Jyunichiro Yasukawa, Yasuhiko Matsumoto, Hiroshi Hamamoto and Kazuhisa Sekimizu J Antibiot 2015 68: 646-648; advance online publication, April 22, 2015; 10.1038/ja.2015.42 Full Text Abstract Staphylococcus aureus is a Gram-positive bacterium that infects the skin and soft tissue in humans.1, 2 The spread of drug-resistant pathogens, such as methicillin-resistant S. aureus strains (MRSA), is a major clinical problem resulting in treatment failure... περισσότερα »
Patients with Multiple Trauma
Correlation Analysis Between the Treatment Time in Emergency Department and Death for *Author(s):* YE Huaikuo, WU Zhanqing, JIA Guoqiang *Pages:* 349-350,353 *Year:* 2015 *Issue:* 5 *Journal:* *Journal of Modern Clinical Medicine* *Keyword:* the treatment time in emergency department; multiple trauma; mortality; *Abstract:* Objective:To investigate the relationship between the treatment time in emergency department and the death of patients with multiple trauma, and to provide the foundation to take measures in clinic for shortening the treatment time in emergency department as wel... περισσότερα »
Misdiagnosis of Cervical Spondylosis
The Meta Analysis of *Author(s):* ZHANG Hong, JIANG Yuan *Pages:* 346-348 *Year:* 2015 *Issue:* 5 *Journal:* *Journal of Modern Clinical Medicine* *Keyword:* cervical spondylosis; misdiagnosis; retrospective analysis; *Abstract:* Objective:To review the cases of cervical spondylosis have been misdiagnosed as other diseases and analyze the causes of misdiagnosis, then provide an clinical thinking for the medical diagnosis and medical classification of cervical spondylosis.Methods:Searched the clinical case reports and reviews of the misdiagnosis of cervical spondylosis had been publ... περισσότερα »
Asymmetric butterfly incision combined with vestibular V-Y advance flap in repairing unilateral secondary cleft lip nasal deformity
Application of *Author(s):* Li Lei, Zhang Zhengwen, Xie Feng, Liu Jun *Pages:* 749-753 *Year:* 2015 *Issue:* 9 *Journal:* *Chinese Journal of Otorhinolaryngology* *Keyword:* Cleft lip; Nose deformities; acquired; Reconstructive surgical procedures; Surgical flaps; Rhinoplasty; *Abstract:* Objective To explore a new surgical method and its effect in repairing secondary nasal deformity of unilateral cleft lip.Methods Sixty-two patients with secondary unilateral lip and nasal deformity were treated with asymmetric butterfly incision combined with vestibular V-Y advance flap,and the su... περισσότερα »
Olfactory bulb volumes with ages and olfactory function
A correlation study on olfactory bulb volumes with ages and olfactory function in healthy adults *Author(s):* Hang Wei, Liu Gang, Han Tong, Zhang Jinling, Zhang Qiang *Pages:* 744-748 *Year:* 2015 *Issue:* 9 *Journal:* *Chinese Journal of Otorhinolaryngology* *Keyword:* Olfactory bulb; Megnetic resonance imaging; Olfaction disorders ; Age factors; Smell; *Abstract:* Objective To analyze the correlation between olfactory bulb(OB) volumes and ages,as well as OB volumes and olfactory function in healthy adults.Methods One hundred healthy subjects,without any diseases which might cause s... περισσότερα »
Triple semicircular canal occlusion in the treatment of intractable Meniere's disease
Long-term efficacy of *Author(s):* Zhang Daogong, Fan Zhaomin, Han Yuechen, Li Yawei, Wang Haibo *Pages:* 733-737 *Year:* 2015 *Issue:* 9 *Journal:* *Chinese Journal of Otorhinolaryngology* *Keyword:* Meniere disease; Semicircular canals; Otologic surgical procedures; Treatment outcome; *Abstract:* Objective To explore the long-term efficacy and safety of triple semicircular canal occlusion (TSCO) in the treatment of intractable Meniere's disease (MD) so as to provide an alternative surgical procedure for treating this disorder.Methods Data from Forty-nine patients,who were referre... περισσότερα »
Endolymphatic sac-mastoid shunt surgery for intractable Meniere's disease
Efficacy of *Author(s):* ZHANG Daogong, FAN Zhaomin, SHI Hongzuo, HAN Yuechen, LV Yafeng , LI Yawei, WANG Guangbin, WANG Haibo *Pages:* 729-732 *Year:* 2015 *Issue:* 9 *Journal:* *Chinese Journal of Otorhinolaryngology* *Keyword:* Meniere disease; Endolymphatic sac; Endolymphatic shunt; Treatment outcome; *Abstract:* Objective To investigate the effect and mechanism of endolymphatic sac-mastoid shunt surgery for intractable Meniere's disease of different stages according to hearing level.Methods Data from 240 patients diagnosed with unilateral MD strictly meeting the criteria issued... περισσότερα »
MRI as a promising tool for evaluation of the stability of cosmetic emulsions
Abstract Objective We have recently established a novel method to evaluate the emulsion stability of pharmaceutical skin cream. The key technology of the method is magnetic resonance imaging (MRI). The purpose of this study is to verify the usefulness of the method in the cosmetic industry. Methods Milky lotion-type emulsions were employed as test samples. We note that the test samples were prepared by taking account of commercial milky lotions. After the sample preparation, a centrifugation treatment (5000*g* for up to 120 min) was implemented to accelerate their destabilization... περισσότερα »
Management of Thrombocytopenia in Chronic Liver Disease: Focus on Pharmacotherapeutic Strategies
Abstract Thrombocytopenia (platelet count <150 × 109/L) often complicates chronic liver disease, impeding optimal management of these patients. The prevalence of this manifestation ranges from 6 % among non-cirrhotic patients with chronic liver disease to 70 % among patients with liver cirrhosis. It has also been shown that the severity of liver disease is associated with both prevalence and level of thrombocytopenia. Its development is often multifactorial, although thrombopoietin is thought to be a major factor. The discovery of and ability to clone thrombopoietin led to new tre...περισσότερα »
Recent Advances in the Development of Antineoplastic Agents Derived from Natural Products
Abstract Through years of evolutionary selection pressures, organisms have developed potent toxins that coincidentally have marked antineoplastic activity. These natural products have been vital for the development of multiagent treatment regimens currently employed in cancer chemotherapy, and are used in the treatment of a variety of malignancies. Therefore, this review catalogs recent advances in natural product-based drug discovery via the examination of mechanisms of action and available clinical data to highlight the utility of these novel compounds in the burgeoning age of p... περισσότερα »
Video head impulse test in peripheral vestibular diseases
Video head impulse test in peripheral vestibular diseases *Author(s):* Lin Ying, Gao Linxi, Han Liping, Lu Lianjun, Chen Yang, Zha Dingjun, Qiu Jianhua *Pages:* 724-728 *Year:* 2015 *Issue:* 9 *Journal:* *Chinese Journal of Otorhinolaryngology* *Keyword:* Vestibular diseases; Vestibular function tests; Reflex; vestibulo-ocular; Saccades; Semicircular canals; *Abstract:* Objectives The function of the semicircular canal receptors and the pathway of the vestibulo-ocular reflex (VOR) can be diagnosed with the clinical head impulse test.The aim of the study was to investigate the horizo... περισσότερα »
ESCC : Vitamin E succinate inhibits proliferation and induces apoptosis
Vitamin E succinate inhibits proliferation and induces apoptosis in human esophageal carcinoma cells TE-1 and Eca-109 *Author(s):* CHEN Haijun, LIU Yuqin, LI Yuze, WANG Xin, LI Nan, LI Dianzhong *Pages:* 357-360 *Year:* 2015 *Issue:* 5 *Journal:* *Carcinogenesis,Teratogenesis and Mutagenesis* *Keyword:* vitamin E succinate; human esophageal carcinoma cells; apoptosis ; proliferation; *Abstract:* OBJECTIVE:To study the effects of vitamin E succinate(VES) on proliferation,apoptosis and expressions of associated protein of human esophageal carcinoma cell line Eca-109 and TE-1.METHODS:Eca...περισσότερα »
speech and language; +21 new citations
21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *speech and language* These pubmed results were generated on 2015/10/27 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Language and Communication Disorders via ola Kala on Inoreader http://ift.tt/QGMHBq(((speech%20and%20language)%20AND%20%222015%2F10%2F24%2007.22%22%5BMHD...περισσότερα »
Risk Factors Associated with Language in Autism Spectrum Disorder: Clues to Underlying Mechanisms.
*Risk Factors Associated with Language in Autism Spectrum Disorder: Clues to Underlying Mechanisms.* J Speech Lang Hear Res. 2015 Oct 20; Authors: Tager-Flusberg H Abstract Purpose: Identifying risk factors associated with neurodevelopmental disorders is an important line of research, as it will lead to the earlier identification of children who could benefit from interventions that support optimal developmental outcomes. The primary goal of this review is to summarize research on risk factors associated with autism spectrum disorder. Method: The review focused on studies on inf...περισσότερα »
Implementation Science: Buzzword or Game Changer?
*Implementation Science: Buzzword or Game Changer?* J Speech Lang Hear Res. 2015 Oct 16; Authors: Douglas NF, Campbell WN, Hinckley JJ Abstract Purpose: To provide a resource of pertinent information concerning implementation science for immediate research application in communication sciences and disorders (CSD). Method: Key terminology related to implementation science is reviewed. Practical suggestions for the application of implementation science theories and methodologies are provided, including an overview of hybrid research designs that simultaneously investigate clinical ...περισσότερα »
Practice-based Research: Another Pathway for Closing the Research-Practice Gap.
*Practice-based Research: Another Pathway for Closing the Research-Practice Gap.* J Speech Lang Hear Res. 2015 Oct 16; Authors: Crooke PJ, Olswang LB Abstract Purpose: Practice-based research is proposed as an additional way to bridge the divide between research and practice. Method: The article compares the traditional, laboratory-based research with research that is generated from practice: practice-based research. The defining features of each are described, with an emphasis on contrasting internal and external validity. Retrospective and prospective practice-based studies ar...περισσότερα »
Voice Disorder Management Competencies: A Survey of School-Based Speech-Language Pathologists in Nebraska.
*Voice Disorder Management Competencies: A Survey of School-Based Speech-Language Pathologists in Nebraska.* Lang Speech Hear Serv Sch. 2015 Oct 23; Authors: Teten AF, DeVeney SL, Friehe MJ Abstract Purpose: The purpose was to determine the self-perceived competence levels in voice disorders of practicing school-based speech-language pathologists (SLPs) and identify correlated variables. Method: Participants were 153 master's-level, school-based SLPs with Nebraska teaching certificate and/or licensure who completed a survey including demographic information and a 25-item voice di...περισσότερα »
Markers, models, and measurement error: Exploring the links between attention deficits and language impairments.
*Markers, models, and measurement error: Exploring the links between attention deficits and language impairments.* J Speech Lang Hear Res. 2015 Oct 23; Authors: Redmond SM Abstract Purpose: The empirical record regarding the expected co-occurrence of attention-deficit/hyperactivity disorder (ADHD) and specific language impairment (SLI) is confusing and contradictory. A research plan is presented that has the potential to untangle links between these two common neurodevelopmental disorders. Method: Data from completed and ongoing research projects examining the relative value of ... περισσότερα »
Auditory cortical deactivation during speech production and following speech perception: an EEG investigation of the temporal dynamics of the auditory alpha rhythm.
*Auditory cortical deactivation during speech production and following speech perception: an EEG investigation of the temporal dynamics of the auditory alpha rhythm.* Front Hum Neurosci. 2015;9:534 Authors: Jenson D, Harkrider AW, Thornton D, Bowers AL, Saltuklaroglu T Abstract Sensorimotor integration (SMI) across the dorsal stream enables online monitoring of speech. Jenson et al. (2014) used independent component analysis (ICA) and event related spectral perturbation (ERSP) analysis of electroencephalography (EEG) data to describe anterior sensorimotor (e.g., premotor cortex,... περισσότερα »
Caregiver Expressed Emotion and Psychiatric Symptoms in African-Americans with Schizophrenia: An Attempt to Understand the Paradoxical Relationship.
*Caregiver Expressed Emotion and Psychiatric Symptoms in African-Americans with Schizophrenia: An Attempt to Understand the Paradoxical Relationship.* Fam Process. 2015 Oct 23; Authors: Gurak K, Weisman de Mamani A Abstract Expressed emotion (EE) is a family environmental construct that assesses how much criticism, hostility, and/or emotional over-involvement a family member expresses about a patient (Hooley, Annual Review of Clinical Psychology, 2007, 3, 329). Having high levels of EE within the family environment has generally been associated with poorer patient outcomes for s...περισσότερα »
Comparison of Two Methods for Inducing Reflex Cough in Patients With Parkinson's Disease, With and Without Dysphagia.
*Comparison of Two Methods for Inducing Reflex Cough in Patients With Parkinson's Disease, With and Without Dysphagia.* Dysphagia. 2015 Oct 23; Authors: Hegland KW, Troche MS, Brandimore A, Okun MS, Davenport PW Abstract Aspiration pneumonia is a common cause of death in people with Parkinson's disease (PD). Dysfunctional swallowing occurs in the majority of people with PD, and research has shown that cough function is also impaired. Previous studies suggest that testing reflex cough by having participants inhale a cough-inducing stimulus through a nebulizer may be a reliable in... περισσότερα »
The Efficacy of Daily Prefrontal Repetitive Transcranial Magnetic Stimulation (rTMS) for Burning Mouth Syndrome (BMS): a Randomized, Controlled Single Blind Study
Publication date: Available online 26 October 2015 *Source:*Brain Stimulation Author(s): Yojiro Umezaki, Bashar W. Badran, William H. DeVries, Jkeonye Moss, Theresa Gonzales, Mark S. George BackgroundBurning mouth syndrome (BMS) is burning oral sensation without any corresponding abnormal findings. In some cases, BMS is refractory to pharmacologic treatments. Repetitive transcranial magnetic stimulation (rTMS) over left prefrontal cortex induces analgesic effect in both acute and chronic pain. However its effect for BMS has not been evaluated.ObjectiveThe aim of this randomized, con... περισσότερα »
Pituitary adenoma invasiveness
Vascular endothelial growth factor,matrix metalloproteinase-9 and tumor cell ultrastructure of pituitary adenoma invasiveness *Author(s):* LIU Ming, XU Zheng-rong, LIU Xi-peng, SUN Hai-feng, SHI Dai-le , Department of Neurosurgery, The First Affiliated Hospital of Hebei North University, Department of Endocrinology, The First Affiliated Hospital of Hebei North University, Department of Internal Medicine, Wanquan County Hospital *Pages:* 1044-1047 *Year:* 2015 *Issue:* 9 *Journal:* *Chinese Journal of Clinical Oncology and Rehabilitation* *Keyword:* Pituitary adenoma; Vascular endothe... περισσότερα »
Differential diagnosis of subacute cerebellar tumor and cerebellar hemorrhage
on computed tomography *Author(s):* WEI Wen-xiang, ZHAO A-ping, Tongchuan People’s Hospital *Pages:* 1034-1036 *Year:* 2015 *Issue:* 9 *Journal:* *Chinese Journal of Clinical Oncology and Rehabilitation* *Keyword:* Cerebellar neoplasms; Subacute cerebellar hemorrhage; Computed tomography; *Abstract:* Objective To explore and analyze differential diagnosis of subacute cerebellar tumor and cerebellar hemorrhage on computed tomography( CT) and summarize the different clinical manifestations,improve the identification of subacute cerebellar tumor and cerebellar hemorrhage,and aim to ra... περισσότερα »
Nanomaterials, Vol. 5, Pages 1782-1809: Enhancing Solar Cell Efficiency Using Photon Upconversion Materials
Photovoltaic cells are able to convert sunlight into electricity, providing enough of the most abundant and cleanest energy to cover our energy needs. However, the efficiency of current photovoltaics is significantly impeded by the transmission loss of sub-band-gap photons. Photon upconversion is a promising route to circumvent this problem by converting these transmitted sub-band-gap photons into above-band-gap light, where solar cells typically have high quantum efficiency. Here, we summarize recent progress on varying types of efficient upconversion materials as well as their ou... περισσότερα »
Cancers, Vol. 7, Pages 2169-2182: The Clinical Relevance of Long Non-Coding RNAs in Cancer
Non-coding RNAs have long been associated with cancer development and progression, and since their earliest discovery, their clinical potential in identifying and characterizing the disease has been pursued. Long non-coding (lncRNAs), a diverse class of RNA transcripts >200 nucleotides in length with limited protein coding potential, has been only modestly studied relative to other categories of non-coding RNAs. However, recent data suggests they too may be important players in cancer. In this article, we consider the value of lncRNAs in the clinical setting, and in particular the... περισσότερα »
Metabolites, Vol. 5, Pages 636-658: Advances in Metabolic Engineering of Cyanobacteria for Photosynthetic Biochemical Production
Engineering cyanobacteria into photosynthetic microbial cell factories for the production of biochemicals and biofuels is a promising approach toward sustainability. Cyanobacteria naturally grow on light and carbon dioxide, bypassing the need of fermentable plant biomass and arable land. By tapping into the central metabolism and rerouting carbon flux towards desirable compound production, cyanobacteria are engineered to directly convert CO2 into various chemicals. This review discusses the diversity of bioproducts synthesized by engineered cyanobacteria, the metabolic pathways use...περισσότερα »
FPGA Implementation of Optimal 3D-Integer DCT Structure for Video Compression
A novel optimal structure for implementing 3D-integer discrete cosine transform (DCT) is presented by analyzing various integer approximation methods. The integer set with reduced mean squared error (MSE) and high coding efficiency are considered for implementation in FPGA. The proposed method proves that the least resources are utilized for the integer set that has shorter bit values. Optimal 3D-integer DCT structure is determined by analyzing the MSE, power dissipation, coding efficiency, and hardware complexity of different integer sets. The experimental results reveal that dir... περισσότερα »
Cancer Screening Using Low-dose Computed Tomography
Lung Cancer Screening Using Low-dose Computed Tomography in 7496 Community Residents with High-risk *Author(s):* XIE Xin, XU Hui-ling, YAN Yu-jie, Shanghai Minhang Center for Disease Control and Prevention *Pages:* 811-814 *Year:* 2015 *Issue:* 10 *Journal:* *China Cancer* *Keyword:* lung cancer; tomography; screening; high risk group; *Abstract:* [Purpose] To explore the effect of low-dose computed tomography(LDCT) screening for lung cancer in a high risk group from local community. [Methods] The 7496 community residents with high risk for lung cancer were enrolled. The person with...περισσότερα »
Toxins, Vol. 7, Pages 4381-4389: Quantitative Detection of Shiga Toxins Directly from Stool Specimens of Patients Associated with an Outbreak of Enterohemorrhagic Escherichia coli in Japan—Quantitative Shiga toxin detection from stool during EHEC outbreak
Detection of Shiga toxins (Stx) is important for accurate diagnosis of Enterohemorrhagic Escherichia coli infection. In this study, we quantitatively analyzed Stx protein in nine patients' stool during an outbreak that occurred in Japan. Highly sensitive immunoassay (bead enzyme-linked immunosorbent assay (bead-ELISA)) revealed that the concentrations of toxins in stool of patients ranged from 0.71 to 10.44 ng/mL for Stx1 and 2.75 to 51.61 ng/mL for Stx2. To our knowledge, this is the first report that reveals the range of Stx protein concentrations in human stools. from #Medicin... περισσότερα »
Mathematics, Vol. 3, Pages 1001-1031: A Cohomology Theory for Commutative Monoids
Extending Eilenberg–Mac Lane's cohomology of abelian groups, a cohomology theory is introduced for commutative monoids. The cohomology groups in this theory agree with the pre-existing ones by Grillet in low dimensions, but they differ beyond dimension two. A natural interpretation is given for the three-cohomology classes in terms of braided monoidal groupoids. from #Medicine via ola Kala on Inoreader http://ift.tt/1Nyez6b via IFTTT
IJGI, Vol. 4, Pages 2292-2305: Image Segmentation Parameter Optimization Considering Within- and Between-Segment Heterogeneity at Multiple Scale Levels: Test Case for Mapping Residential Areas Using Landsat Imagery
Multi-scale/multi-level geographic object-based image analysis (MS-GEOBIA) methods are becoming widely-used in remote sensing because single-scale/single-level (SS-GEOBIA) methods are often unable to obtain an accurate segmentation and classification of all land use/land cover (LULC) types in an image. However, there have been few comparisons between SS-GEOBIA and MS-GEOBIA approaches for the purpose of mapping a specific LULC type, so it is not well understood which is more appropriate for this task. In addition, there are few methods for automating the selection of segmentation ...περισσότερα »
Future Internet, Vol. 7, Pages 405-428: Dynamical Trust and Reputation Computation Model for B2C E-Commerce
Trust is one of the most important factors that influence the successful application of network service environments, such as e-commerce, wireless sensor networks, and online social networks. Computation models associated with trust and reputation have been paid special attention in both computer societies and service science in recent years. In this paper, a dynamical computation model of reputation for B2C e-commerce is proposed. Firstly, conceptions associated with trust and reputation are introduced, and the mathematical formula of trust for B2C e-commerce is given. Then a dyna... περισσότερα »
Diseases, Vol. 3, Pages 282-293: The Role of Environmental Factors in the Development of Celiac Disease: What Is New?
Celiac disease (CD) is a systemic immune-mediated disorder caused by the ingestion of gluten-containing grains in genetically susceptible persons. It is one of the most common lifelong disorders, affecting approximately 1% of the general population. The prevalence of CD has increased in developed countries over recent decades, pointing to the role of additional environmental triggers other than gluten. It has been hypothesized that intestinal infections, the amount and quality of gluten, the intestinal microbiota, and early nutrition are all possible triggers of the switch from to... περισσότερα »
Catalysts, Vol. 5, Pages 1815-1830: On the Effect of Preparation Methods of PdCe-MOR Catalysts as NOx CH4-SCR System for Natural Gas Vehicles Application
In the present work, the effect of several parameters involved in the preparation of PdCe-HMOR catalysts active for NOx selective catalytic reduction with methane (NOx CH4-SCR) was studied. Results show that the catalytic performance of Pd-HMOR is better when palladium is introduced by ion-exchange, namely at room temperature. It was also shown that Pd loading does not influence the formation of cerium species, namely surface Ce4+ (CeO2) species and CeO2 species in interaction with Pd. However, when Ce is introduced before Pd, more surface CeO2 species are stabilized in the suppor...περισσότερα »
Mathematics, Vol. 3, Pages 1032-1044: A Fast O(N logN) Finite Difference Method for the One-Dimensional Space-Fractional Diffusion Equation
This paper proposes an approach for the space-fractional diffusion equation in one dimension. Since fractional differential operators are non-local, two main difficulties arise after discretization and solving using Gaussian elimination: how to handle the memory requirement of O(N2) for storing the dense or even full matrices that arise from application of numerical methods and how to manage the significant computational work count of O(N3) per time step, where N is the number of spatial grid points. In this paper, a fast iterative finite difference method is developed, which has a... περισσότερα »
High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma
Background. Despite the many studies examining thyroid cancers, the effect of thyroid autoantibodies on differentiated thyroid carcinoma (DTC) remains unclear. Objective. To investigate the association between serologic thyroid autoantibodies (ATAs) and DTC, we retrospectively evaluated data of thyroid nodules obtained from patients who underwent thyroid surgery. Methods. Data of thyroid nodules obtained from 1,638 patients who underwent thyroid surgery were evaluated. Thyroid autoimmunity was assessed by the presence of thyroglobulin (TgAb) or thyroid peroxidase antibodies (TPOAb)...περισσότερα »
Breast Cancer-Derived Extracellular Vesicles: Characterization and Contribution to the Metastatic Phenotype
The study of extracellular vesicles (EVs) in cancer progression is a complex and rapidly evolving field. Whole categories of cellular interactions in cancer which were originally presumed to be due solely to soluble secreted molecules have now evolved to include membrane-enclosed extracellular vesicles (EVs), which include both exosomes and shed microvesicles (MVs), and can contain many of the same molecules as those secreted in soluble form but many different molecules as well. EVs released by cancer cells can transfer mRNA, miRNA, and proteins to different recipient cells within...περισσότερα »
XiangshaLiujunzi decoction alleviates the symptoms of functional dyspepsia by regulating brain–gut axis and production of neuropeptides
Background: Chinese medicine xiangshaliujunzi decoction (XSLJZD) plays a key role in treating functional dyspepsia (FD), a common clinical gastrointestinal disorder. However, the mechanism of this disease is unclear. Brain–gut axis regulates food intake behaviour, and this regulatory mechanism is mediated by neuropeptides. Brain–gut axis impairment and neuropeptide alteration may be the pathological mechanisms of FD, and brain–gut axis regulation may influence the action of medicine. Methods: In our experiment, the effect of XSLJZD on FD was evaluated in terms of food intake, sucr... περισσότερα »
Editorial Board
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 from #Medicine via ola Kala on Inoreader http://ift.tt/1Ny8Nl1 via IFTTT
Table of Contents
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 from #Medicine via ola Kala on Inoreader http://ift.tt/1Ny8MNL via IFTTT
Editors' Selections From This Issue: Volume 96 / Number 11 / November 2015
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 from #Medicine via ola Kala on Inoreader http://ift.tt/1Ny8MgF via IFTTT
Masthead
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 from #Medicine via ola Kala on Inoreader http://ift.tt/1Ny8KFK via IFTTT
Impact of Outpatient Rehabilitation Medicare Reimbursement Caps on Utilization and Cost of Rehabilitation Care After Ischemic Stroke: Do Caps Contain Costs?
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 Author(s): Annie N. Simpson, Heather S. Bonilha, Abby S. Kazley, James S. Zoller, Kit N. Simpson, Charles Ellis ObjectiveTo estimate the proportion of patients with ischemic stroke who fall within and above the total outpatient rehabilitation caps before and after the Balanced Budget Act of 1997 took effect; and to estimate the cost of poststroke outpatient rehabilitation cost and resource utilization in these patients before and after the implementation of the caps.Design... περισσότερα »
Longitudinal Study of Headache Trajectories in the Year After Mild Traumatic Brain Injury: Relation to Posttraumatic Stress Disorder Symptoms
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 Author(s): Kathryn Sawyer, Kathleen R. Bell, Dawn M. Ehde, Nancy Temkin, Sureyya Dikmen, Rhonda M. Williams, Tiara Dillworth, Jeanne M. Hoffman ObjectiveTo examine headache trajectories among persons with mild traumatic brain injury (MTBI) in the year after injury and the relation of headache trajectory to posttraumatic stress disorder (PTSD) at 1 year postinjury.DesignProspective, longitudinal study.SettingParticipants were recruited through a university medical center and... περισσότερα »
Changes in Cerebellar Activation After Onabotulinumtoxin A Injections for Spasticity After Chronic Stroke: A Pilot Functional Magnetic Resonance Imaging Study
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 Author(s): Chia-Lin Chang, Douglas J. Weber, Michael C. Munin ObjectiveTo investigate the effect of reducing spasticity via onabotulinumtoxin A (Obtx-A) injection on cerebellar activation after chronic stroke during unilateral gripping.DesignPre-post, case series.SettingOutpatient spasticity clinic.ParticipantsIndividuals with chronic spasticity (N=4).InterventionsUpper-limb Obtx-A injection.Main Outcome MeasuresFunctional magnetic resonance imaging (fMRI) was used to meas... περισσότερα »
Smart Dressing Glows Green When Wound Becomes Infected
[image: smart-wound-dressing] A team of British scientists has developed a smart wound dressing that can detect the presence of bacterial infection. The ability to clean wounds of infections before they develop further would revolutionize wound therapy. The dressing glows green when in contact with a bacterial biofilm, an encapsulated mass of bacteria protected by a film through which passing drugs is very difficult. From the study abstract in *ACS Applied Materials & Interfaces*: The dressing is made of a hydrated agarose film in which the fluorescent dye containing vesicles wer...περισσότερα »
Calcium Hydroxide Paste Vital Pulp Therapy on Carious Pulpitis
Effect of *Author(s):* He Yanyang, Department of Stomatology, Songyang People’s Hospital *Pages:* 526-528 *Year:* 2015 *Issue:* 9 *Journal:* *Chinese Journal of Pharmacoepidemiology* *Keyword:* Carious pulpitis; Calcium hydroxide paste; Vital pulp therapy; Curative effect; *Abstract:* Objective: To observe curative effect and safety of calcium hydroxide paste vital pulp therapy on carious pulpitis. Methods: 80 cases of patients with carious pulpitis were divided into 40 cases of patients in observation group( 46 teeth with disease) and 40 cases of patients in control group( 48 tee... περισσότερα »
Therapeutic Drug Monitoring of Vancomycin in Obese Patients with Infection
Systemic Review of *Author(s):* Dong Qianru, Chen Ken, Zhai Suodi, Department of Pharmacy, Peking University Third Hospital, Department of Pharmacy Administration and Clinical Pharmacy, Peking University Pharmaceutical Science *Pages:* 513-516 *Year:* 2015 *Issue:* 9 *Journal:* *Chinese Journal of Pharmacoepidemiology* *Keyword:* Vancomycin; Therapeutic drug monitoring; Obese; Systematic review; *Abstract:* Objective: To systematic evaluate the necessity of vancomycin therapeutic drug monitoring in obese patients with infection compared with normal patients with infection. Methods:... περισσότερα »
Massively parallel DNA sequencing from routinely processed cytological smears
BACKGROUND Data generated by next-generation sequencing technologies have a pivotal role in precision medicine. These high-throughput techniques are preferentially performed on fresh tissue, but there is an increasing need for protocols adapted to materials derived from formalin-fixed, paraffin-embedded tissue and cytology specimens. METHODS The aim of this work was to show that cytological material collected from archival smears processed for routine diagnoses could be used for massively parallel sequencing and array-based genomic analysis for further studies. RESULTS As a pro...περισσότερα »
Life expectancy of young adults with follicular lymphoma
Background This study was aimed at investigating the clinical features and outcomes of follicular lymphoma (FL) patients younger than 40 years, which have not been extensively investigated yet. Patients and methods One hundred and fifty-five patients younger than 40 years were retrospectively studied from a series of 1002 FL patients diagnosed in four different European Oncology Centres (Barcelona, Spain; Bellinzona, Switzerland; London, UK; Novara, Italy) from 1985 to 2010. Results Patients younger than 40 had a lower incidence of elevated LDH, high beta2-microglobulin, and a... περισσότερα »
Maintenance rituximab after autologous stem cell transplantation in patients with mantle cell lymphoma
Background High-dose therapy and autologous stem cell transplantation (ASCT) improves outcomes for patients with mantle cell lymphoma (MCL), but relapse ultimately occurs in most patients. Recently presented interim results from a phase III prospective trial suggest maintenance rituximab (MR) after ASCT for MCL improves progression-free survival (PFS). The maturation of these data and any benefit of MR on overall survival (OS) remain to be defined. Patients and methods In this retrospective study, we examined a cohort of consecutive patients with MCL that underwent ASCT for MCL ... περισσότερα »
The ESMO magnitude of clinical benefit scaling tool: from theory to practice
from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1idaf0J via IFTTT
A randomized phase II study comparing paclitaxel-carboplatin-bevacizumab with or without nitroglycerin patches in patients with stage IV nonsquamous nonsmall-cell lung cancer: NVALT12 (NCT01171170)
Background Nitroglycerin (NTG) increases tumor blood flow and oxygenation by inhibiting hypoxia-inducible-factor (HIF)-1. A randomized phase II study has shown improved outcome when NTG patches were added to vinorelbine/cisplatin in patients with advanced nonsmall-cell lung cancer (NSCLC). In addition, there is evidence that the combination of bevacizumab and HIF-1 inhibitors increases antitumor activity. Patients and methods In this randomized phase II trial, chemo-naive patients with stage IV nonsquamous NSCLC were randomized to four cycles of carboplatin (area under the curv... περισσότερα »
Disease characteristics, treatment patterns, and outcomes of follicular lymphoma in patients 40 years of age and younger: an analysis from the National Lymphocare Study
Background Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma, with median age at diagnosis in the seventh decade. FL in young adults (YAs), defined as diagnosis at ≤40 years, is uncommon. No standard approaches exist guiding the treatment of YA FL, and little is known about their disease characteristics and outcomes. To gain further insights into YA FL, we analyzed the National LymphoCare Study (NLCS) to describe characteristics, initial treatments, and outcomes in this population versus patients aged >40 years. Patients and methods Using the NLCS databa...περισσότερα »
Carfilzomib and pomalidomide in patients with relapsed and/or refractory multiple myeloma with baseline risk factors
While survival times have increased over the last decade, most patients with multiple myeloma (MM) eventually relapse and become refractory to therapy. The treatment of patients with relapsed and/or refractory MM is frequently further complicated by the presence of pre-existing comorbidities that arise from an advanced disease state and of toxicities stemming from prior antimyeloma treatment. Carfilzomib and pomalidomide have recently been approved for the treatment of patients with relapsed and refractory MM. While these agents represent important additions to the available treat... περισσότερα »
RandomizEd phase II trial of Sunitinib four weeks on and two weeks off versus Two weeks on and One week off in metastatic clear-cell type REnal cell carcinoma: RESTORE trial
Background The standard sunitinib schedule, 4 weeks on, followed by 2 weeks off (4/2 schedule), is associated with troublesome toxicities, and maintenance of adequate sunitinib dosing and drug levels, which are essential for achieving an optimal treatment outcome, is challenging. The objective of this study was to investigate the efficacy and safety of an alternative sunitinib dosing schedule of 2 weeks on and 1 week off (2/1 schedule) compared with the standard sunitinib schedule of 4 weeks on and 2 weeks off (4/2 schedule). Patients and methods In this multicenter, randomized...περισσότερα »
Central adiposity, obesity during early adulthood, and pancreatic cancer mortality in a pooled analysis of cohort studies
Background Body mass index (BMI), a measure of obesity typically assessed in middle age or later, is known to be positively associated with pancreatic cancer. However, little evidence exists regarding the influence of central adiposity, a high BMI during early adulthood, and weight gain after early adulthood on pancreatic cancer risk. Design We conducted a pooled analysis of individual-level data from 20 prospective cohort studies in the National Cancer Institute BMI and Mortality Cohort Consortium to examine the association of pancreatic cancer mortality with measures of centr... περισσότερα »
A phase III randomized trial of adding topical nitroglycerin to first-line chemotherapy for advanced nonsmall-cell lung cancer: the Australasian lung cancer trials group NITRO trial
Background We sought to determine whether the substantial benefits of topical nitroglycerin with first-line, platinum-based, doublet chemotherapy in advanced nonsmall-cell lung cancer (NSCLC) seen in a phase II trial could be corroborated in a rigorous, multicenter, phase III trial. Patients and methods Patients starting one of five, prespecified, platinum-based doublets as first-line chemotherapy for advanced NSCLC were randomly allocated treatment with or without nitroglycerin 25 mg patches for 2 days before, the day of, and 2 days after, each chemotherapy infusion. Progressio... περισσότερα »
A randomized, controlled phase III trial of nab-Paclitaxel versus dacarbazine in chemotherapy-naïve patients with metastatic melanoma
Background The efficacy and safety of *nab*-paclitaxel versus dacarbazine in patients with metastatic melanoma was evaluated in a phase III randomized, controlled trial. Patients and methods Chemotherapy-naïve patients with stage IV melanoma received *nab*-paclitaxel 150 mg/m2 on days 1, 8, and 15 every 4 weeks or dacarbazine 1000 mg/m2 every 3 weeks. The primary end point was progression-free survival (PFS) by independent radiologic review; the secondary end point was overall survival (OS). Results A total of 529 patients were randomized to *nab*-paclitaxel (*n* = 264) or d... περισσότερα »
High burden of copy number alterations and c-MYC amplification in prostate cancer from BRCA2 germline mutation carriers
Background Germline *BRCA2* mutations are associated with poorer outcome prostate cancer (PCa) compared with sporadic tumours but this association remains to be characterised. In this study, we aim to assess if there is a signature set of copy number alterations (CNA) that could aid to the identification of *BRCA2*-mutated tumours and would assist us to understand their aggressive clinical behaviour. Methods High-resolution array comparative genomic hybridisation profiling of DNA from PCa and matched morphologically normal prostate samples from 9 *BRCA2* germline mutation carri...περισσότερα »
Randomized phase III trial of treatment duration for oral uracil and tegafur plus leucovorin as adjuvant chemotherapy for patients with stage IIB/III colon cancer: final results of JFMC33-0502
Background While adjuvant chemotherapy is preferable for high-risk colon cancer, treatment duration is controversial. Oral uracil and tegafur (UFT)/leucovorin (LV) is widely used as a standard adjuvant chemotherapy for colon cancer in Japan. We conducted a phase III trial to investigate the optimal duration of adjuvant chemotherapy for stage IIB/III colon cancer. Patients and methods Patients with curatively resected stage IIB/III colon cancer were eligible for enrollment in this trial. Patients were registered within 6 weeks after surgery and were randomly assigned to receive ... περισσότερα »
Long-term exposure to circulating platinum is associated with late effects of treatment in testicular cancer survivors
Background The success of cisplatin-based (Platinol, Bristol-Myers Squibb Company, New York, NY, USA) chemotherapy for testicular cancer comes at the price of long-term and late effects related to healthy tissue damage. We assessed and modelled serum platinum (Pt) decay after chemotherapy and determined relationships between long-term circulating Pt levels and known late effects. Patients and methods In 99 testicular cancer survivors, treated with cisplatin-based chemotherapy, serum and 24-h urine samples were collected during follow-up (1–13 years after treatment). To build a ...περισσότερα »
Era-by-era improvement in survival for elderly patients with Hodgkin lymphoma; outcome data from a large population-based cohort
from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1N5fV9U via IFTTT
Development and validation of a nomogram to predict survival in incurable cachectic cancer patients on home parenteral nutrition
Background The use of home parenteral nutrition (HPN) in incurable cancer patients is extremely varied across different countries and institutions. In order to assess the clinical impact implied, we previously conducted a survey of incurable cancer patients receiving HPN, which shows that survival was markedly affected by Karnofsky performance status (KPS), tumor spread, Glasgow prognostic score (GPS) and tumor site. The aim of this study was to develop a nomogram incorporating the above factors for survival prediction. Patients and methods We gathered a series of 579 patients, ...περισσότερα »
REBECA: a phase I study of bevacizumab and whole-brain radiation therapy for the treatment of brain metastasis from solid tumours
from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1N5fQDo via IFTTT
Oncology 2020: a drug development and approval paradigm
from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1iamICq via IFTTT
Histologic transformation in marginal zone lymphomas
Background Histologic transformation (HT) is a poorly understood event in patients with marginal zone lymphoma (MZL). The aim of this study was to analyze incidence and risk factors for HT in a large series of MZL patients. Patients and methods The studied cohort included 340 MZL patients diagnosed and treated between 1995 and 2012: 157 extranodal MZLs [mucosa-associated lymphoid tissue (MALT) lymphoma, 46%], 85 splenic MZLs (SMZLs, 25%) and 37 nodal MZLs (NMZLs, 11%). Sixty-one patients (18%) had bone marrow infiltration at presentation, with or without detectable involvement o... περισσότερα »
Benefits and Risks of Making Use of Aspirin in the Secondary Prevention of Stroke
Prospective Cohort Study on *Author(s):* Sun Yihong, Jiang Hui, Wu Zhubing, Wang Xianyue, Gao Zhan, Zhou Dacheng, Zheng Rongyuan, Neurology Department of The People’s Hospital of Putuo, Neurology Department of The First Affiliated Hospital, Wenzhou Medical College *Pages:* 509-512 *Year:* 2015 *Issue:* 9 *Journal:* *Chinese Journal of Pharmacoepidemiology* *Keyword:* Aspirin; Secondary prevention of stroke; Prospective cohort study; Cerebral infarction; Upper gastro-intestinal bleeding; Intracranial hemorrhage; *Abstract:* Objective: To investigate the benefits and risks of initiat... περισσότερα »
MRI guided stereotactic biopsy in the diagnosis of intracranial lesions
The clinical application of MRI guided stereotactic biopsy in the diagnosis of intracranial lesions in operation *Author(s):* Sun Baisheng, Du Haifeng, Jiang Hui, Department of medical imaging, Armed Police Corps in Shandong Province Hospital *Pages:* 142-144 *Year:* 2015 *Issue:* 3 *Journal:* *Chinese Journal of Stereotactic and Functional Neurosurgery* *Keyword:* MRI guide; Stereotactic biopsy operation; Brain disease; *Abstract:* Objective To investigate the clinical application value of MRI guided stereotactic biopsy in the diagnosis of intracranial lesions in operation.Methods 6... περισσότερα »
Large-Scale $$\hbox {CO}_2$$ CO 2 Storage in a Deep Saline Aquifer: Uncertainties in Predictions Due to Spatial Variability of Flow Parameters and Their Modeling
Abstract Scarce data and uncertainties in the spatial variation of geological properties lead to different possible models of these heterogeneities. The aim of this study is to compare the pressure results and \(\hbox {CO}_2\) behavior of different permeability field models for a large-scale \(\hbox {CO}_2\) injection in a deep saline aquifer. Five ways of representing heterogeneities are tested and compared. The simplest representation defines homogeneous equivalent properties over the entire domain. A second representation is obtained by considering homogeneous layers. Two other ... περισσότερα »
Commentary on: The Alar Rim Flap: A Novel Technique to Manage Malpositioned Lateral Crura
from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1GvoWIi via IFTTT
Resistant Mechanism of Anti-anaerobic Antibiotics
Research Progress on Resistant Mechanism of Anti-anaerobic Antibiotics and its Clinical Medication *Author(s):* SHEN Min-na, GU Jue-fen, School of Life Science and Technology , China Pharmaceutical University *Pages:* 481-486 *Year:* 2015 *Issue:* 4 *Journal:* *Anti-Infection Pharmacy* *Keyword:* anaerobe; antibiotics; mechanisms of resistance; clinical medication; *Abstract:* Anaerobic bacteria are important constituents of the body normal flora,but can cause many kinds of endogenous disease pathogenic bacteria in human body. Because of improving modern culture and separation condi... περισσότερα »
Inhibitory Effect of Sitafloxacin Hydrate on Staphylococcus Aureus
Study on Inhibitory Effect of Sitafloxacin Hydrate on Staphylococcus Aureus in Mice *Author(s):* GAO Ya-ping, HEI Yan, JI Xing-she, LIU Yu, RONG Zhi-gang, ZHU Hao-wen, SHEN Bei-fen, YANG Guang, Dep.of Immunology,Institute of Basic Medical Sciences, The People’s Liberation Army Academy of Military Medical Sciences, Institute of Orbital Disease,People’s Armed Police Corps General Hospital, Jiangsu Wuzhong Pharmaceutical Group Co.Ltd *Pages:* 497-499 *Year:* 2015 *Issue:* 4 *Journal:* *Anti-Infection Pharmacy* *Keyword:* Staphylococcus aureus; sitafloxacin hydrate; peritonitis; *Abstra... περισσότερα »
Skin Test Result of Penicillin
Analysis of Reasons Affecting Skin Test Result of Penicillin and Its Countermeasures *Author(s):* FAN Guo-bin, LI Su-juan, SHEN Qin-hua, The People’s Hospital of Dongxihu District *Pages:* 516-519 *Year:* 2015 *Issue:* 4 *Journal:* *Anti-Infection Pharmacy* *Keyword:* penicillin; skin test; analysis; *Abstract:* Objective: To analyze the reasons affecting the skin test result of penicillin and its countermeasures.Methods:The main reasons that caused the high false positive rate of penicillin skin test were analyzed through comparison of the rules about penicillin skin test in differ... περισσότερα »
Intrathecal Analgesia for Chronic Refractory Pain: Current and Future Prospects
Abstract The intrathecal drug-delivery system (IDDS) is one mode of infusing analgesic medications directly into the cerebrospinal fluid in close proximity to their site of action. This modality has been employed in patients with refractory pain either due to malignant or non-malignant causes for over 30 years. Unfortunately, and despite the number of years it has been in use, there is still a scarcity of rigorous evidence to guide its integration into clinical practice. Current best evidence is inconclusive as to the comparative effectiveness and harms of the IDDS relative to rou... περισσότερα »
A phase I, dose-escalation study of volasertib combined with nintedanib in advanced solid tumors
Background Volasertib is a potent and selective cell-cycle kinase inhibitor that induces mitotic arrest and apoptosis by targeting Polo-like kinases. This study determined the maximum tolerated dose (MTD) and pharmacokinetics of volasertib combined with nintedanib, a potent and orally bioavailable triple angiokinase inhibitor, in patients with advanced solid tumors. Patients and methods This open-label, dose-escalation trial recruited patients with advanced metastatic solid tumors following failure of conventional treatment (NCT01022853; Study 1230.7). Volasertib was administere... περισσότερα »
Integration of Cyanine, Merocyanine and Styryl Dye Motifs with Synthetic Bacteriochlorins
Abstract Understanding the effects of substituents on spectral properties is essential for the rational design of tailored bacteriochlorins for light-harvesting and other applications. Towards this goal, three new bacteriochlorins containing previously unexplored conjugating substituents have been prepared and characterized. The conjugating substituents include two positively charged species, 2-(*N*-ethyl 2-quinolinium)vinyl- (*B-1*) and 2-(*N*-ethyl 4-pyridinium)vinyl- (*B-2*), and a neutral group, acroleinyl- (*B-3*); the charged species resemble cyanine (or styryl) dye motifs w... περισσότερα »
Effectiveness of a Wheelchair Skills Training Program for Powered Wheelchair Users: A Randomized Controlled Trial
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 Author(s): R. Lee Kirby, William C. Miller, Francois Routhier, Louise Demers, Alex Mihailidis, Jan Miller Polgar, Paula W. Rushton, Laura Titus, Cher Smith, Mike McAllister, Chris Theriault, Kara Thompson, Bonita Sawatzky ObjectivesTo test the hypothesis that powered wheelchair users who receive the Wheelchair Skills Training Program (WSTP) improve their wheelchair skills in comparison with a control group that receives standard care, and secondarily to assess goal achievem...περισσότερα »
Impact of Injection-Guiding Techniques on the Effectiveness of Botulinum Toxin for the Treatment of Focal Spasticity and Dystonia: A Systematic Review
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 Author(s): Anca-Irina Grigoriu, Mickael Dinomais, Olivier Rémy-Néris, Sylvain Brochard ObjectiveTo conduct a systematic review of the impact of different injection-guiding techniques on the effectiveness of botulinum toxin type A (BoNT-A) for the treatment of focal spasticity and dystonia.Data SourcesMEDLINE via PubMed, Academic Search Premier, PASCAL, The Cochrane Library, Scopus, SpringerLink, Web of Science, EM Premium, and PsycINFO.Study SelectionTwo reviewers independ... περισσότερα »
Measurement Characteristics and Clinical Utility of the Functional Gait Assessment Among Individuals With Vestibular Impairment
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 Author(s): Karen H. Lambert, Jennifer L. Stoskus, Teresa Rice, Linda B. Horn, Elizabeth Dannenbaum, Matthew R. Scherer from #Medicine via ola Kala on Inoreader http://ift.tt/1Ny8B50 via IFTTT
Journal of Trauma and Acute Care Surgery
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
- Surgical Wound Assessment by Sonography (SWATS) in the Prediction of Surgical Wound Infections.Barrett, Christopher D.; Celestin, Arthur; Eskander, Mariam F.; Fish, Emily; Glass, Charity C.; Murillo, Rudy; Gospodinov, Georgi; Gupta, Alok; Hauser, Carl J., 2015-10-23 07:00:00 AM BACKGROUND: Surgical site infections (SSI) are important sources of morbidity, prolonged hospital stays and readmissions. So they have become a major economic burden. We hypothesized that surgical wound assessment by sonography (SWATS) used at the bedside would detect wound fluid col... περισσότερα »
Editorial Board
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1Ny8Nl1 via IFTTT
Table of Contents
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1Ny8MNL via IFTTT
Editors' Selections From This Issue: Volume 96 / Number 11 / November 2015
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1Ny8MgF via IFTTT
Masthead
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1Ny8KFK via IFTTT
Impact of Outpatient Rehabilitation Medicare Reimbursement Caps on Utilization and Cost of Rehabilitation Care After Ischemic Stroke: Do Caps Contain Costs?
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 Author(s): Annie N. Simpson, Heather S. Bonilha, Abby S. Kazley, James S. Zoller, Kit N. Simpson, Charles Ellis ObjectiveTo estimate the proportion of patients with ischemic stroke who fall within and above the total outpatient rehabilitation caps before and after the Balanced Budget Act of 1997 took effect; and to estimate the cost of poststroke outpatient rehabilitation cost and resource utilization in these patients before and after the implementation of the caps.Design... περισσότερα »
Longitudinal Study of Headache Trajectories in the Year After Mild Traumatic Brain Injury: Relation to Posttraumatic Stress Disorder Symptoms
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 Author(s): Kathryn Sawyer, Kathleen R. Bell, Dawn M. Ehde, Nancy Temkin, Sureyya Dikmen, Rhonda M. Williams, Tiara Dillworth, Jeanne M. Hoffman ObjectiveTo examine headache trajectories among persons with mild traumatic brain injury (MTBI) in the year after injury and the relation of headache trajectory to posttraumatic stress disorder (PTSD) at 1 year postinjury.DesignProspective, longitudinal study.SettingParticipants were recruited through a university medical center and... περισσότερα »
Changes in Cerebellar Activation After Onabotulinumtoxin A Injections for Spasticity After Chronic Stroke: A Pilot Functional Magnetic Resonance Imaging Study
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 Author(s): Chia-Lin Chang, Douglas J. Weber, Michael C. Munin ObjectiveTo investigate the effect of reducing spasticity via onabotulinumtoxin A (Obtx-A) injection on cerebellar activation after chronic stroke during unilateral gripping.DesignPre-post, case series.SettingOutpatient spasticity clinic.ParticipantsIndividuals with chronic spasticity (N=4).InterventionsUpper-limb Obtx-A injection.Main Outcome MeasuresFunctional magnetic resonance imaging (fMRI) was used to meas... περισσότερα »
Effectiveness of a Wheelchair Skills Training Program for Powered Wheelchair Users: A Randomized Controlled Trial
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 Author(s): R. Lee Kirby, William C. Miller, Francois Routhier, Louise Demers, Alex Mihailidis, Jan Miller Polgar, Paula W. Rushton, Laura Titus, Cher Smith, Mike McAllister, Chris Theriault, Kara Thompson, Bonita Sawatzky ObjectivesTo test the hypothesis that powered wheelchair users who receive the Wheelchair Skills Training Program (WSTP) improve their wheelchair skills in comparison with a control group that receives standard care, and secondarily to assess goal achievem...περισσότερα »
Feasibility and Safety of Cardiopulmonary Exercise Testing in Multiple Sclerosis: A Systematic Review
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 Author(s): Lizanne Eva van den Akker, Martin Heine, Nikki van der Veldt, Joost Dekker, Vincent de Groot, Heleen Beckerman ObjectiveTo investigate the feasibility and safety of cardiopulmonary exercise testing (CPET) in patients with multiple sclerosis (MS).Data SourcesPubMed, EMBASE, CINAHL, SPORTDiscus, PsycINFO, ERIC, and the Psychology and Behavioral Sciences Collection were searched up to October 2014. References from retrieved articles were examined to identify additi... περισσότερα »
Impact of Injection-Guiding Techniques on the Effectiveness of Botulinum Toxin for the Treatment of Focal Spasticity and Dystonia: A Systematic Review
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 Author(s): Anca-Irina Grigoriu, Mickael Dinomais, Olivier Rémy-Néris, Sylvain Brochard ObjectiveTo conduct a systematic review of the impact of different injection-guiding techniques on the effectiveness of botulinum toxin type A (BoNT-A) for the treatment of focal spasticity and dystonia.Data SourcesMEDLINE via PubMed, Academic Search Premier, PASCAL, The Cochrane Library, Scopus, SpringerLink, Web of Science, EM Premium, and PsycINFO.Study SelectionTwo reviewers independ... περισσότερα »
Measurement Characteristics and Clinical Utility of the Functional Gait Assessment Among Individuals With Vestibular Impairment
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: November 2015 *Source:*Archives of Physical Medicine and Rehabilitation, Volume 96, Issue 11 Author(s): Karen H. Lambert, Jennifer L. Stoskus, Teresa Rice, Linda B. Horn, Elizabeth Dannenbaum, Matthew R. Scherer from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1Ny8B50 via IFTTT
JOURNAL ONKOLOGIE
Aktivität bei Lymphomen bestätigt: Bendamustin behauptet seine Stellung in der Hämatologie Die Bedeutung von Levact® (Bendamustin) als effektiver und gut verträglicher Chemotherapiepartner bestätigte sich auch auf der diesjährigen Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie in Basel. Langzeitdaten zweier Studien der StiL nach 7 bzw. 8 Jahren Nachbeobachtungszeit konnten die überlegene... EGFR-Mutationspositives NSCLC: Resistenz gegen Erlotinib vorbeugen mit Caseinkinase-1-alpha-Inhibition? Patiente...περισσότερα »
Sheathless transradial coronary angioplasty in an achondroplasic patient with ST elevation myocardial infarction
We present a case of a 50-year-old man with achondroplasia, who presented with anterior ST segment myocardial infarction (STEMI). He was taken urgently to the catheterisation laboratory. Owing to his short stature, it was not possible to insert a radial artery sheath so he underwent a sheathless primary percutaneous coronary intervention (PCI) through the right radial artery, with no complication. He was shifted to the coronary care unit and had an uneventful hospital course. He was discharged in stable condition and follows up regularly as an outpatient. from Cases via ola Kala ... περισσότερα »
Laparoscopic treatment of intestinal obstruction caused by an uncommon congenital band
Congenital bands represent a rare cause of small bowel obstruction. We report a case of intestinal obstruction caused by an uncommon form of congenital band in a 16-year-old girl. The diagnosis was strongly evoked preoperatively by CT scan and the intestinal obstruction was successfully treated using a laparoscopic approach. from Cases via ola Kala on Inoreader http://ift.tt/1kMdzC0 via IFTTT
Donohue syndrome and use of continuous subcutaneous insulin pump therapy
Donohue syndrome is a rare autosomal recessive condition caused by severe loss-of-function mutations in the insulin receptor (INSR) gene. The diagnosis is made on clinical, biochemical and genetic grounds. Mutations are found on chromosome 19p13.2, and code for mutations in the INSR gene. Treatment is challenging and often unsuccessful, and relies on maintaining normoglycaemia and avoiding fasting; in some patients, recombinant human insulin-like growth factor (rhIGF-1) has been trialled. The prognosis is poor, with most babies dying in infancy. Ethically, it is important to consi...περισσότερα »
Severe acute measles pneumonitis: virus isolation in bronchoalveolar lavage fluid
In the past few years, several endemic outbreaks of measles have been recognised, not only in children but also in adults, with severe and, occasionally, even fatal complications, possibly due to delayed diagnosis of the disease in adult medicine and decreasing vaccination rates. Furthermore, the treatment consists of supportive measures only. We present a case of severe measles pneumonitis in a 42-year-old man, a travel returnee, proven by direct virus isolation with PCR from bronchoalveolar lavage fluid. CT findings and pulmonary function testing revealed features of obstructive... περισσότερα »
Swallow syncope caused by third-degree atrioventricular block
We report a case of a patient with more than 30 years of repeated syncopes, always following food intake. The patient was diagnosed with a swallow-related third-degree atrioventricular block and successfully treated with an artificial pacemaker. from Cases via ola Kala on Inoreader http://ift.tt/1kMdnTc via IFTTT
What the mind does not know, the eyes do not see: a rare congenital fusion of the odontoid process to the atlantal hemiarch
Congenital spinal fusion of an odontoid process to an atlantal hemiarch is very rare. The unfamiliarity of the medical fraternity with this congenital malformation can easily be mistaken for an acute fracture, chronic infection or inflammatory disease. We present our experience of managing an adult who presented with neck pain after a motor vehicle accident. Radiological investigation revealed congenital fusion of the odontoid process to the atlantal hemiarch. The prevalence, embryology and clinical significance of this anomaly are discussed. As the natural progression of this ano... περισσότερα »
Effects of neck-specific exercises compared to waiting list for individuals with chronic whiplash associated disorders: a prospective randomized controlled study
Publication date: Available online 26 October 2015 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Anneli Peolsson, Maria Landén Ludvigsson, Ann-Marie Tigerfors, Gunnel Peterson ObjectiveTo determine, whether 3-months of neck-specific exercises could benefit individuals with chronic whiplash-associated disorders (WAD) who were on a waiting list for treatment.DesignA prospective, randomized controlled studySettingPrimary health careParticipants41 individuals (31 women, 10 men; mean age=38 y, SD=11.2) with chronic (6 to 36 months) WAD, grades 2 and 3, were analyze...περισσότερα »
Behavioral Sciences, Vol. 5, Pages 443-460: Age-Related Response Bias in the Decoding of Sad Facial Expressions
Recent studies have found that age is negatively associated with the accuracy of decoding emotional facial expressions; this effect of age was found for actors as well as for raters. Given that motivational differences and stereotypes may bias the attribution of emotion, the aim of the present study was to explore whether these age effects are due to response bias, that is, the unbalanced use of response categories. Thirty younger raters (19–30 years) and thirty older raters (65–81 years) viewed video clips of younger and older actors representing the same age ranges, and decoded ... περισσότερα »
Agronomy, Vol. 5, Pages 506-518: Polyethylene Glycol (PEG)-Treated Hydroponic Culture Reduces Length and Diameter of Root Hairs of Wheat Varieties
Wheat is an important cereal crop worldwide that often suffers from moisture deficits at the reproductive stage. Polyethylene glycol (PEG)-treated hydroponic conditions create negative osmotic potential which is compared with moisture deficit stress. An experiment was conducted in a growth chamber to study the effects of PEG on root hair morphology and associated traits of wheat varieties. Plants of 13 wheat varieties were grown hydroponically and three different doses of PEG 6000 (w/v): 0% (control), 0.3% and 0.6% (less than −1 bar) were imposed on 60 days after sowing for 20 day... περισσότερα »
Bioengineering, Vol. 2, Pages 184-203: Converting Sugars to Biofuels: Ethanol and Beyond
To date, the most significant sources of biofuels are starch- or sugarcane-based ethanol, which have been industrially produced in large quantities in the USA and Brazil, respectively. However, the ultimate goal of biofuel production is to produce fuels from lignocellulosic biomass-derived sugars with optimal fuel properties and compatibility with the existing fuel distribution infrastructure. To achieve this goal, metabolic pathways have been constructed to produce various fuel molecules that are categorized into fermentative alcohols (butanol and isobutanol), non-fermentative al... περισσότερα »
Les apnées du sommeil disparaissent-elles une fois l’acromégalie traitée ?
Publication date: Available online 27 October 2015 *Source:*Revue des Maladies Respiratoires Author(s): M. Bruyneel, S. Haumont, F. Devuyst L'acromégalie est une maladie rare liée à une sécrétion excessive d'hormone de croissance qui entraîne des atteintes cardiovasculaires, respiratoires, métaboliques, articulaires, osseuses et néoplasiques, dont le syndrome d'apnées du sommeil. Le devenir du syndrome d'apnées du sommeil est variable sous traitement : amélioration, statu quo ou détérioration. Nous rapportons trois observations cliniques illustrant cette évolution imprévisible.Acrom...περισσότερα »
Sensitivity estimation in time-of-flight list-mode positron emission tomography
Purpose: An accurate quantification of the images in positron emission tomography (PET) requires knowing the actual sensitivity at each voxel, which represents the probability that a positron emitted in that voxel is finally detected as a coincidence of two gamma rays in a pair of detectors in the PET scanner. This sensitivity depends on the characteristics of the acquisition, as it is affected by the attenuation of the annihilation gamma rays in the body, and possible variations of the sensitivity of the scanner detectors. In this work, the authors propose a new approach to handl... περισσότερα »
Periodontal disease classifications revisited
An American Academy of Periodontology Task Force has recently published a report on the Update to the 1999 Classification of Periodontal Diseases and Conditions, which is a focused update outlining changes to be included in a comprehensive update planned for 2017. We discuss the proposed changes, and their rationales, and conclude that the periodontal classification carousel will continue to spin until it is realized that the only way forward is a profound reconsideration of what we hope to achieve with classifications. from OroFacial Medicine via ola Kala on Inoreader http://ift...περισσότερα »
Morphing technique reveals intact perception of object motion and disturbed perception of emotional expressions by low-functioning adolescents with Autism Spectrum Disorder
Publication date: December 2015 *Source:*Research in Developmental Disabilities, Volume 47 Author(s): Bora Han, Charles Tijus, Florence Le Barillier, Jacqueline Nadel A morphing procedure has been designed to compare directly the perception of emotional expressions and of moving objects. Morphing tasks were presented to 12 low-functioning teenagers with Autism Spectrum Disorder (LF ASD) compared to 12 developmental age-matched typical children and a group presenting ceiling performance. In a first study, when presented with morphed stimuli of objects and emotional faces, LF ASD showe...περισσότερα »
Semantic conflicts are resolved differently by adults with and without ADHD
Publication date: December 2015 *Source:*Research in Developmental Disabilities, Volume 47 Author(s): Dorit Segal, Nira Mashal, Lilach Shalev Attention Deficit/Hyperactivity Disorder (ADHD) is a common neurobehavioral disorder characterized by various behavioral and cognitive difficulties. Previous studies indicated that children with ADHD have language difficulties, including difficulties in metaphor understanding but the relation between metaphor processing and specific cognitive functions needs further investigation. In the current study we examined how adults with and without AD... περισσότερα »
Effects of neck-specific exercises compared to waiting list for individuals with chronic whiplash associated disorders: a prospective randomized controlled study
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Publication date: Available online 26 October 2015 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Anneli Peolsson, Maria Landén Ludvigsson, Ann-Marie Tigerfors, Gunnel Peterson ObjectiveTo determine, whether 3-months of neck-specific exercises could benefit individuals with chronic whiplash-associated disorders (WAD) who were on a waiting list for treatment.DesignA prospective, randomized controlled studySettingPrimary health careParticipants41 individuals (31 women, 10 men; mean age=38 y, SD=11.2) with chronic (6 to 36 months) WAD, grades 2 and 3, were analyze...περισσότερα »
Impact of shortened dental arches on oral health-related quality of life
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Summary This study described the prevalence of adults with shortened dental arches (SDA) in Brazil, specifically assessing the differences of oral health-related quality of life [the prevalence and severity of oral impacts on daily performance (OIDP)] by dentition status. We analysed data from the 2010 National Survey of Oral Health in Brazil, including home interviews and oral examinations. The assessment of SDA used two alternative definitions: having 3–5 natural occlusal units (OUs) in posterior teeth or having 4 OUs in posterior teeth. Both definitions included having intact a... περισσότερα »
Assessment of Lemon Balm (Melissa officinalis L.) Hydrogels: Quality and Bioactivity in Skin Cells
The aim of the study was to design gels with lemon balm extract, assess their quality, and investigate the effect of rosmarinic acid on skin cells in normal conditions and under oxidative stress. Methods. The quantities of rosmarinic acid (RA) released from gels were evaluated by applying the HPLC technique. HaCaT cell viability was assessed by using the MTT method. ROS generation was measured using DCFH-DA dye. The results showed that the gelling material affected the release of RA content from gels. Lower and slower RA content release was determined in carbomer-based gels. After ...περισσότερα »
Sequence specific recognition of ssDNA by fluorophore 3-hydroxyflavone
Publication date: Available online 26 October 2015 *Source:*Journal of Photochemistry and Photobiology B: Biology Author(s): Asli Capan, Muge S. Bostan, Erkan Mozioglu, Muslum Akoz, Ahmet C. Goren, Mehmet S. Eroglu, Turan Ozturk A fully water soluble 3-hydroxyflavone (3HF) derivative, N-(3-hydroxy-4′-flavonyl)-N,N,N-trimethylammonium sulfate (3HFNMe3) was synthesized. Invesitgation of its emissions at varying wavelengths revealed that it had three emission bands of normal (N⁎), anionic (A⁎) and tautomeric (T⁎), in ultrapure water. Recognition of single-stranded ten ssDNA chains, hav... περισσότερα »
The reliability and validity of the Developmental Coordination Disorder Questionnaire’07 for children aged 4–6 years in mainland China
Publication date: December 2015 *Source:*Research in Developmental Disabilities, Volume 47 Author(s): Jing Hua, Guixiong Gu, Qingqing Zhu, Da Wo, Ming Liu, Jiang-Qin Liu, Jie Mao, Tao Duan An effective population-based screening tool is needed to identify possible cases of Developmental Coordination Disorder (DCD) among preschool children in mainland China. We examined the psychometric properties of the DCD questionnaire'07 (DCDQ'07) in Chinese children aged 4–6. A total of 3316 children from 10 nursery schools were involved in the study. Internal consistency and test–retest reliabi... περισσότερα »
Imaging of abdominal and pelvic injuries from the Boston Marathon bombing
Emergency Radiology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1H70jMQ via IFTTT
Are regional variations in activity of dispatcher-assisted cardiopulmonary resuscitation associated with out-of-hospital cardiac arrests outcomes? A nation-wide population-based cohort study
Resuscitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PRWi67 via IFTTT
Long-term renal function after endovascular aneurysm repair
Clinical Journal of the American Society of Nephrology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1H70hEK via IFTTT
Atrial fibrillation burden and short-term risk of stroke: Case-crossover analysis of continuously recorded heart rhythm from cardiac electronic implanted devices
Circulation: Arrhythmia and Electrophysiology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PRWdPT via IFTTT
The use of the transparotid approach for surgical treatment of condylar fractures – own experience
Journal of Cranio-Maxillofacial Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1H70cRu via IFTTT
Coronary computed tomography angiography versus traditional care: comparison of one-year outcomes and resource use
Annals of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PRW9zq via IFTTT
Assessing bicycle-related trauma using the biomarker S100B reveals a correlation with total injury severity
European Journal of Trauma and Emergency Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1H70843 via IFTTT
Interdisciplinary intervention reduced the risk of being persistently depressive among older patients with hip fracture
Geriatrics and Gerontology International from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1H705VT via IFTTT
Protective effects of scutellarin on human cardiac microvascular endothelial cells against hypoxia-reoxygenation injury and its possible target-related proteins
Evidence-based Complementary and Alternative Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1H702JT via IFTTT
Emergency department use of computed tomography for children with ventricular shunts
The Journal of Pediatrics from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1H700S3 via IFTTT
Transdiscal C6–C7 contralateral C7 nerve root transfer in the surgical repair of brachial plexus avulsion injuries
Acta Neurochirurgica from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PRW3bf via IFTTT
Plasma bioactive-adrenomedullin as a prognostic biomarker in acute heart failure
The American Journal of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1H6ZXFT via IFTTT
Comparative performance of ATRIA, CHADS2, and CHA2DS2-VASc risk scores predicting stroke in patients with atrial fibrillation: Results from a national primary care database
JACC - Journal of the American College of Cardiology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PRVZIr via IFTTT
The use of inhaled nitrous oxide for analgesia in adult ED patients – A pilot study
The American Journal of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1H6ZSSL via IFTTT
Traumatic and non-traumatic adrenal emergencies
Emergency Radiology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PRVWME via IFTTT
Evaluation of hematological markers in minor head trauma in the emergency room
European Journal of Trauma and Emergency Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1H6ZOlW via IFTTT
Posttraumatic midface pain: clinical significance of the anterior superior alveolar nerve and canalis sinuosus
Annals of Plastic Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1H6ZKCK via IFTTT
Journal of oral rehabilitation: what's in a name?
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1H79fSv via IFTTT
Predictive model for survival in patients having repeat radiation treatment for painful bone metastases
Publication date: Available online 26 October 2015 *Source:*Radiotherapy and Oncology Author(s): Edward Chow, Keyue Ding, Wendy R. Parulekar, Rebecca K.S. Wong, Yvette M. van der Linden, Daniel Roos, William F. Hartsell, Peter Hoskin, Jackson S.Y. Wu, Abdenour Nabid, Jan Willem Leer, Ernest Vonk, Scott Babington, William F. Demas, Carolyn F. Wilson, Michael Brundage, Liting Zhu, Ralph M. Meyer PurposeTo establish a survival prediction model in the setting of a randomized trial of re-irradiation for painful bone metastases.MethodsData were randomly divided into training and testing s... περισσότερα »
Pedunculated mobile aortic arch thrombus as a cause for acute stroke
Description A 69-year-old man presented with sudden-onset dysphasia and right hemiparesis. MRI of the brain revealed an acute left frontoparietal infarct (figure 1). Carotid Dopplers were normal and ECG showed sinus rhythm. Transthoracic echocardiogram (TTE) revealed a highly mobile 1.33 cm echogenic mass attached to the superior surface of the aortic arch (figure 2). Subsequent transoesophageal echocardiogram (TOE) did not identify a left atrial appendage thrombus or patent foramen ovale. The patient was started on intravenous heparin prior to warfarin. Given the high-risk natu... περισσότερα »
[Medical and economic evaluation of oncological inpatients in 14 Belgian hospitals].
Related Articles *[Medical and economic evaluation of oncological inpatients in 14 Belgian hospitals].* Bull Cancer. 2015 Oct 20; Authors: Pirson M, Van den Bulcke J, Di Pierdomenico L, Martins D, Leclercq P Abstract INTRODUCTION: A prospective payment system per DRG is announced in Belgium. Is this kind of financing system adequate for oncology? Objectives of this study are: to analyze medical and economical characteristics of oncological inpatients and evaluate the homogeneity of costs and length of stay per DRG. METHODS: The study was realized in 14 Belgian hospitals, with 201...περισσότερα »
Metabolomics for Improved Understanding and Prediction of Cardiometabolic Diseases—Recent Findings from Human Studies
Abstract Cardiometabolic dieases are the main causes of morbidity and mortality worldwide. Despite large clinical and basic research efforts to improve the understanding of the molecular mechanisms of these conditions and to develop prediagnostic markers still remains a challenge. Recently, targeted and untargeted metabolomics technique became available for comprehensive studies of small molecules in biological samples in large-scale studies. MS- or NMR-based techniques dominate and have recently been used extensively in studies to identify predictive biomarkers, monitoring therap...περισσότερα »
Benzofuroxan derivatives N-Br and N-I induce intrinsic apoptosis in melanoma cells by regulating AKT/BIM signaling and display anti metastatic activity in vivo
Abstract Background Malignant melanoma is an aggressive type of skin cancer, and despite recent advances in treatment, the survival rate of the metastatic form remains low. Nifuroxazide analogues are drugs based on the substitution of the nitrofuran group by benzofuroxan, in view of the pharmacophore similarity of the nitro group, improving bioavailability, with higher intrinsic activity and less toxicity. Benzofuroxan activity involves the intracellular production of free-radical species. In the present work, we evaluated the antitumor effects of different benzofuroxan derivatives... περισσότερα »
Prediction of response to anti-EGFR antibody-based therapies by multigene sequencing in colorectal cancer patients
Abstract Background The anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (moAbs) cetuximab or panitumumab are administered to colorectal cancer (CRC) patients who harbor wild-type *RAS* proto-oncogenes. However, a percentage of patients do not respond to this treatment. In addition to mutations in the *RAS* genes, mutations in other genes, such as *BRAF*, *PI3KCA*, or *PTEN*, could be involved in the resistance to anti-EGFR moAb therapy. Methods In order to develop a comprehensive approach for the detection of mutations and to eventually identify other genes res...περισσότερα »
School-based brief psycho-educational intervention to raise adolescent cancer awareness and address barriers to medical help-seeking about cancer: a cluster randomised controlled trial
Abstract Objectives Raising cancer awareness and addressing barriers to help-seeking may improve early diagnosis. The aim was to assess whether a psycho-educational intervention increased adolescents' cancer awareness and addressed help-seeking barriers. Methods This was a cluster randomised controlled trial involving 2173 adolescents in 20 schools. The intervention was a 50-min presentation delivered by a member of Teenage Cancer Trust's (UK charity) education team. Schools were stratified by deprivation and roll size and randomly allocated to intervention/control conditions wi...περισσότερα »
Immunological factors influencing clinical outcome in lung cancer patients after telomerase peptide vaccination
Abstract We have previously reported two trials in non-small cell lung cancer (NSCLC) evaluating vaccine therapy with the telomerase peptide GV1001. The studies demonstrated considerable differences in survival among immune responders, highlighting that an immune response is not necessarily beneficial. In the present study, we conducted long-term clinical follow-up and investigated immunological factors hypothesized to influence clinical efficacy. Peripheral blood mononuclear cells from 33 NSCLC trial patients and 15 healthy donors were analyzed by flow cytometry for T regulatory ... περισσότερα »
Five-fraction stereotactic radiosurgery (SRS) for single inoperable high-risk non-small cell lung cancer (NSCLC) brain metastases
Abstract Background Achieving durable local control while limiting normal tissue toxicity with definitive radiation therapy in the management of high-risk brain metastases remains a radiobiological challenge. The objective of this study was to examine the local control and toxicity of a 5-fraction stereotactic radiosurgical approach for treatment of patients with inoperable single high-risk NSCLC brain metastases. Methods This retrospective analysis examines 20 patients who were deemed to have "high-risk" brain metastases. High-risk tumors were defined as those with a maximum dia... περισσότερα »
Immunological factors influencing clinical outcome in lung cancer patients after telomerase peptide vaccination
Abstract We have previously reported two trials in non-small cell lung cancer (NSCLC) evaluating vaccine therapy with the telomerase peptide GV1001. The studies demonstrated considerable differences in survival among immune responders, highlighting that an immune response is not necessarily beneficial. In the present study, we conducted long-term clinical follow-up and investigated immunological factors hypothesized to influence clinical efficacy. Peripheral blood mononuclear cells from 33 NSCLC trial patients and 15 healthy donors were analyzed by flow cytometry for T regulatory ... περισσότερα »
Has Angelina Jolie effect Led to an Increase in Risk Reducing Mastectomy and Breast Reconstruction in Wales; a Retrospective, Single Centre Cohort Study
Publication date: Available online 26 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Cathy M. Malcolm, Muhammad Umair Javed, Dai Nguyen from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1WfsPrJ via IFTTT
Serum Levels of Renin, Angiotensin Converting Enzyme and Angiotensin II in Patients Treated by Surgical Excision, Propranolol and Captopril for Problematic Proliferating Infantile Haemangioma
Publication date: Available online 26 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): L. Sulzberger, R. Baillie, T. Itinteang, S. de Jong, R. Marsh, P. Leadbitter, S.T. Tan The role of the renin-angiotensin system (RAS) in the biology of infantile haemangioma (IH) and its accelerated involution induced by β-blockers was initially proposed in 2010. This led to the first clinical trial in 2012 using low-dose captopril, an angiotensin converting enzyme inhibitor, demonstrating a similar response in these tumours. The current study aimed to compar... περισσότερα »
The Kinect Recording System for Objective Three- and Four-Dimensional Breast Assessment with Image Overlays
Publication date: Available online 26 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Henseler Helga, Bonkat Sarah Kim, Vogt Peter, Rosenhahn Bodo IntroductionWe investigated the application of the validated portable Kinect camera for three-and fourdimensional breast assessment in female life models.MethodBreast images from six life models were captured using the Kinect camera. Capture was conducted with taking three different arm positions while standing upright: with the arms straight down, straight up to the side at 90° and straight all the ...περισσότερα »
Thin Melanomas (<1mm) and New NICE Guidance for Sentinel Lymph Node Biopsy
Publication date: Available online 26 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): J.A. Dunne, J. Odili, B.W.E.M. Powell from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1LUXTmt via IFTTT
Second toe microsurgical free-flap for aesthetic and sensory reconstruction of palmar soft tissue defects of fingers
Publication date: Available online 26 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Jia-xiang Gu, Subhash Regmi, Nai-chen Zhang, Hong-jun Liu, Wen-zhong Zhang, Tao Xu Objectivesto illustrate the surgical methods and clinical efficacy of microsurgical free-flaps obtained from second toe for the reconstruction of palmar soft-tissue defect of fingers.MethodsWe enrolled 22 patients (13 men and 9 women), who received second toe free-flap for 22 finger defects between August 2007 and July 2013. The average age was 35 years (range, 18-62 years). Th...περισσότερα »
Composite Orbital Reconstruction Using the Vascularized Segmentalized Osteo-Fascio-Cutaneous Fibula Flap
Publication date: Available online 26 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): T.Kalle Lundgren, Marco Pignatti, Martin Halle, Giulia Boscaini, Ann-Charlotte Docherty Skogh, M.D. Giorgio De Santis Reconstruction of composite orbital defects must address the orbit and an exposed skull base and/or maxillary region. The orbit should not only be covered but also reshaped to accomodate the orbital contents or an epithesis when needed. A rationale for a near anatomical reconstruction of the orbit, together with adjacent dead space obliteration...περισσότερα »
The Role of Elective Amputation In Patients With Traumatic Brachial Plexus Injury
Publication date: Available online 26 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Andrés A. Maldonado, Michelle F. Kirchner, Robert J. Spinner, Allen T. Bishop, Alexander Y. Shin BackgroundDespite undergoing complex brachial plexus surgical reconstructions and rehabilitation, some patients request an elective amputation. This study evaluates the role of elective amputation after brachial plexus injury.MethodsA retrospective chart review was performed for all the 2140 patients with brachial plexus injuries treated with elective amputation b... περισσότερα »
Stromal Vascular Fraction – a regenerative reality? Part 2 – Mechanisms of regenerative action
Publication date: Available online 24 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): James Guo, Andrew Nguyen, Derek A. Banyard, Darya Fadavi, Jason D. Toranto, Garrett A. Wirth, Keyianoosh Z. Paydar, Gregory R.D. Evans, Alan D. Widgerow Adipose tissue is a rich source of cells with emerging promise for tissue engineering and regenerative medicine. The stromal vascular fraction (SVF), in particular, is an eclectic composite of cells with progenitor activity that includes preadipocytes, mesenchymal stem cells, pericytes, endothelial cells, and...περισσότερα »
Challenges in global microsurgery: a six year review of outcomes at an East African hospital
Publication date: Available online 24 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Isabelle Citron, George Galiwango, Andrew Hodges BackgroundFree tissue transfer is an invaluable resource for reconstruction of complex defects. There is very little evidence as to the feasibility and outcomes of microsurgery performed in East Africa. This study will analyse outcomes of 114 consecutive free flaps, performed over 6 years at a single plastic surgery unit in Uganda. It aims to demonstrate that despite its challenges, successful microsurgical prac... περισσότερα »
Prophylactic Amifostine Prevents a Pathologic Vascular Response in a Murine Model of Expander-Based Breast Reconstruction
Publication date: Available online 24 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Y. Polyatskaya, N.S. Nelson, J.J. Rodriguez, A.R. Zheutlin, S.S. Deshpande, P.A. Felice, A. Donneys, S.R. Buchman BackgroundAlthough expander-based breast reconstruction is the most commonly used method of reconstruction worldwide, it continues to be plagued with complication rates as high as 60% when radiotherapy is implemented. We hypothesized that quantitative measures of radiotherapy-induced vascular injury can be mitigated by utilizing amifostine in a mu... περισσότερα »
Changes in the immunohistochemical localization of the glycine receptor in the superior olivary complex of adult circling mice.
*Changes in the immunohistochemical localization of the glycine receptor in the superior olivary complex of adult circling mice.* Mol Med Rep. 2015 Oct 13; Authors: Yoo YB, Maskey D, Kim MJ Abstract Circling mice is a mutant model of spontaneous deafness exhibiting degenerated spiral ganglion cells in the cochlea and loss of organ of Corti. The balance between glycinergic inhibition and glutamatergic excitation in the lateral superior olive (LSO) is essential for the detection of interaural level differences. Long term weakening of glycinergic synaptic inhibition in the LSO may ... περισσότερα »
Hearing Aid Use and Associated Factors in South Korea.
*Hearing Aid Use and Associated Factors in South Korea.* Medicine (Baltimore). 2015 Oct;94(42):e1580 Authors: Moon IJ, Baek SY, Cho YS Abstract Despite the high prevalence of hearing impairment in the elderly, the rate of hearing aid use is still low. The objectives of this study were to report the nation-wide prevalence of hearing aid use in the Korean population and to determine the associated factors with hearing aid use utilizing a nationally representative data set.We obtained data from the 2010 to 2012 Korea National Health and Nutrition Examination Surveys, which were cro... περισσότερα »
A 'calcium capacitor' shapes cholinergic inhibition of cochlear hair cells.
[image: http:--media.wiley.com-assets-7278-93-Pu] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *A 'calcium capacitor' shapes cholinergic inhibition of cochlear hair cells.* J Physiol. 2014 Aug 15;592(Pt 16):3393-401 Authors: Fuchs PA Abstract Efferent cholinergic neurons project from the brainstem to inhibit sensory hair cells of the vertebrate inner ear. This inhibitory synapse combines the activity of an unusual class of ionotropic cholinergic receptor with that of nearby calcium-dependent potassium channels to shunt and hyperpolarize the hair cell. Postsynaptic calc... περισσότερα »
Synaptic Mechanisms Shaping Delay-Tuned Combination-Sensitivity in The Auditory Thalamus of Mustached Bats
Publication date: Available online 27 October 2015 *Source:*Hearing Research Author(s): John A. Butman, Nobuo Suga For the processing of target-distance information, delay-tuned auditory neurons of the mustached bat show facilitative responses to a combination of signal elements of a biosonar pulse-echo pair with a specific echo delay. They are initially produced in the inferior colliculus by facilitative responses based on the coincidence of the rebound response following glycinergic inhibition to the first harmonic of the pulse and a short-latency response to the 2nd–4th harmonics... περισσότερα »
Visceral adiposity is a predictor of parathyroid hormone levels in healthy adults
Abstract Purpose Parathyroid hormone (PTH) has been shown to correlate positively with fat mass, however there are no studies that have investigated whether this association is a result of, or is modified by, body fat distribution. The aim of this study was to investigate the association of PTH with several body composition indices, namely visceral (VAT) and subcutaneous adiposity (SCAT) as well as with lean mass and with serum leptin, which has been reported to increase PTH. Methods This was a cross-sectional study in which PTH was measured by chemiluminescent assay; body fat an...περισσότερα »
Synthetic Cannabinoids and Their Effects on the Cardiovascular System
Publication date: Available online 26 October 2015 *Source:*The Journal of Emergency Medicine Author(s): Jonathan Von Der Haar, Soheila Talebi, Farzaneh Ghobadi, Shailinder Singh, Roger Chirurgi, Pingle Rajeswari, Hossein Kalantari, Getaw Worku Hassen BackgroundIn the past couple of years, there has been an outbreak of synthetic cannabinoid (SC) use in major cities in the United States. Patients can present with various symptoms affecting the central nervous and cardiovascular systems. The effects of endocannabinoid on contractility and Ca2+ signaling have been shown through both ca... περισσότερα »
Is capsule endoscopy appropriate for elderly patients? The influence of ageing on findings and diagnostic yield: An Italian retrospective study
Few data are available on the use of capsule endoscopy in the elderly. from C via ola Kala on Inoreader http://ift.tt/1Gvbm7U via IFTTT
Bowel ultrasound imaging in patients with cystic fibrosis: Relationship with clinical symptoms and CFTR genotype
Ultrasound imaging is used to assess bowel abnormalities in gastrointestinal diseases. We aimed to assess the rate of predefined bowel ultrasound signs and their relationship with gastrointestinal symptoms and the cystic fibrosis transmembrane conductance regulator (CFTR) genotype in cystic fibrosis patients in regular follow-up. from C via ola Kala on Inoreader http://ift.tt/1GvblRf via IFTTT
The microbiome of the maxillary sinus and middle nasal meatus in chronic rhinosinusitis.
*The microbiome of the maxillary sinus and middle nasal meatus in chronic rhinosinusitis.* Rhinology. 2015 Oct 25; Authors: Ivanchenko OA, Karpishchenko SA, Kozlov RS, Krechikova OI, Otvagin IV, Sopko ON, Piskunov GZ, Lopatin AS Abstract AIM: This multicenter study was focused on the identification of the microorganisms inhabiting the maxillary sinus and middle nasal meatus in chronic rhinosinusitis. METHODOLOGY: 112 middle meatus swabs and 112 maxillary sinus aspirates from 103 patients were available for culture. RESULTS: A total of 244 strains of microorganisms representing mo...περισσότερα »
Common airborne fungi induce species-specific effects on upper airway inflammatory and remodelling responses.
*Common airborne fungi induce species-specific effects on upper airway inflammatory and remodelling responses.* Rhinology. 2015 Oct 25; Authors: Sproson EL, Thomas KM, Lau LC, Harries PG, Howarth PH, Salib RJ Abstract OBJECTIVE: Whilst the exact cause of chronic rhinosinusitis (CRS) remains elusive, it is clear that both inflammation and remodelling are key disease processes. Environmental fungi have been linked to airway inflammation in CRS; however, their role in the pathogenesis of this condition remains controversial. The current consensus suggests that whilst fungi may not b... περισσότερα »
Radiobiological evaluation of intensity modulated radiation therapy treatments of patients with head and neck cancer: A dual-institutional study.
*Radiobiological evaluation of intensity modulated radiation therapy treatments of patients with head and neck cancer: A dual-institutional study.* J Med Phys. 2015 Jul-Sep;40(3):165-169 Authors: Narayanasamy G, Pyakuryal AP, Pandit S, Vincent J, Lee C, Mavroidis P, Papanikolaou N, Kudrimoti M, Sio TT Abstract In clinical practice, evaluation of clinical efficacy of treatment planning stems from the radiation oncologist's experience in accurately targeting tumors, while keeping minimal toxicity to various organs at risk (OAR) involved. A more objective, quantitative method may b... περισσότερα »
Role of miR-138 in the regulation of larynx carcinoma cell metastases.
*Role of miR-138 in the regulation of larynx carcinoma cell metastases.* Tumour Biol. 2015 Oct 24; Authors: Gao S, Wang J, Xie J, Zhang T, Dong P Abstract The cases of larynx carcinoma (LC) with poor prognosis largely result from the distal metastases of the primary tumor. Since microRNAs (miRNAs) play critical roles during cancer metastases, determination of the involved miRNAs in the regulation of the LC metastases may provide novel therapeutic targets for LC treatment. Here, we studied the LC specimens from the patients and found that the levels of miR-138 were significantly d... περισσότερα »
Preference evaluation and perceived sensory comparison of fluticasone furoate and mometasone furoate intranasal sprays in allergic rhinitis.
*Preference evaluation and perceived sensory comparison of fluticasone furoate and mometasone furoate intranasal sprays in allergic rhinitis.* Auris Nasus Larynx. 2015 Oct 20; Authors: Yonezaki M, Akiyama K, Karaki M, Goto R, Inamoto R, Samukawa Y, Kobayashi R, Kobayashi E, Hoshikawa H Abstract OBJECTIVE: Intranasal corticosteroid sprays (INCSs) are commonly used for therapy of allergic rhinitis (AR). Adherence to regular use of INCSs is influenced by patient perception and preferences of products. The study objective was to compare perceived sensory attributes of fluticasone fu...περισσότερα »
Optimizing hereditary angioedema management through tailored treatment approaches.
*Optimizing hereditary angioedema management through tailored treatment approaches.* Expert Rev Clin Immunol. 2015 Oct 23;:1-13 Authors: Nasr IH, Manson AL, Al Wahshi HA, Longhurst HJ Abstract Hereditary angioedema (HAE) is a rare but serious and potentially life threatening autosomal dominant condition caused by low or dysfunctional C1 esterase inhibitor (C1-INH) or uncontrolled contact pathway activation. Symptoms are characterized by spontaneous, recurrent attacks of subcutaneous or submucosal swellings typically involving the face, tongue, larynx, extremities, genitalia or b...περισσότερα »
Imaging Acute Airway Obstruction in Infants and Children.
*Imaging Acute Airway Obstruction in Infants and Children.* Radiographics. 2015 Oct 23;:150096 Authors: Darras KE, Roston AT, Yewchuk LK Abstract Acute airway obstruction is much more common in infants and children than in adults because of their unique anatomic and physiologic features. Even in young patients with partial airway occlusion, symptoms can be severe and potentially life-threatening. Factors that predispose children to airway compromise include the orientation of their larynx, the narrow caliber of their trachea, and their weak intercostal muscles. Because the clinic... περισσότερα »
[Laryngeal Tube Position Shift after Chest Compression: Comparison of Fixation Methods Using Durapore Tape, Multipore Tape, or a Neck Tape].
Related Articles *[Laryngeal Tube Position Shift after Chest Compression: Comparison of Fixation Methods Using Durapore Tape, Multipore Tape, or a Neck Tape].* Masui. 2015 May;64(5):566-8 Authors: Seno H, Komasawa N, Fujiwara S, Miyazaki S, Tatsumi S, Minami T Abstract BACKGROUND: The laryngeal tube (LT ; Smiths Medical, Minnesota, U. S. A) is an inflatable supraglottic device for emergency airway management such as during chest compression, the instability after insertion remains a problem. METHODS: We investigated the effectiveness of three fixation methods of LT using a manikin... περισσότερα »
[Spontaneous Respiration Technique for Pediatric Microlaryngeal Surgery without Endotracheal Intubation].
Related Articles *[Spontaneous Respiration Technique for Pediatric Microlaryngeal Surgery without Endotracheal Intubation].* Masui. 2015 May;64(5):524-9 Authors: Torii N, Tachibana K, Fujita N, Yamashita T, Terada Y, Kinouchi K Abstract We report the anesthetic management of microlaryngeal surgery in children using tubeless total intravenous anesthesia (TIVA) without endotracheal intubation under spontaneous breathing. In 9 patients (median age : 4.9 yr. range 1 months-14 years, body weight : 17 kg, range 3-61 kg), 19 procedures were performed with TIVA using propofol and remifen... περισσότερα »
Carcinogenic efects of circadian disruption
: an epigenetic viewpoint *Author(s):* Abbas Salavaty, Department of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz *Pages:* 375-383 *Year:* 2015 *Issue:* 9 *Journal:* *Chinese Journal of Cancer* *Keyword:* Cancer; Epigenetics; Circadian rhythms; Circadian disruption; Chronotherapy; *Abstract:* Circadian rhythms refer to the endogenous rhythms that are generated to synchronize physiology and behavior with 24-h environmental cues. These rhythms are regulated by both external cues and molecular clock mechanisms in almost all cells. Disruption of circadian rhythms, wh... περισσότερα »
Atrial Fibrillation After Treatment for Differentiated Thyroid Carcinoma
Increased Risk of Esther N. Klein Hesselink, Joop D. Lefrandt, Edwin P. Schuurmans, Johannes G. M. Burgerhof, Bart Groen, Ron T. Gansevoort, Anouk N. A. van der Horst-Schrivers,Robin P. F. Dullaart, Isabelle C. Van Gelder, Adrienne H. Brouwers, Michiel Rienstra, and Thera P. Links Address all correspondence and requests for reprints to: Prof Dr Thera P. Links, University of Groningen, University Medical Center Groningen, Department of Endocrinology, HPC AA31, P.O. Box 30.001, 9700 RB Groningen, The Netherlands . E-mail: t.p.links@umcg.nl. DOI: http://dx.doi.org/10.1210/jc.2015-2782 ...περισσότερα »
Autoimmune thyroid disorders : Circulating microvesicles regulate Treg and Th17 differentiation
Circulating microvesicles regulate Treg and Th17 differentiation in human autoimmune thyroid disorders Ana Rodríguez-Muñoz1, Rebeca Martínez-Hernández1, Ana Ramos-Leví1, Ana Serrano-Somavilla1, Roberto González-Amaro3, Francisco Sánchez-Madrid2,Hortensia de la Fuente2,*, and Mónica Marazuela1,* Address all correspondence and requests for reprints to: *Corresponding author and person to whom reprint requests should be addressed:* Mónica Marazuela, M.D, Ph.D, Department of Endocrinology, Hospital Universitario de la Princesa, UAM, C/ Diego de León, 62, 28 006, Madrid. Spain , Phone: (+... περισσότερα »
Subclinical thyroid dysfunction and frailty
Subclinical Thyroid Dysfunction and Frailty among Older Men Vanessa S. Virgini1, Nicolas Rodondi2, Peggy M. Cawton3, Stephanien Litwack Harrison3, Andrew R. Hoffman4, Eric S. Orwoll5, Kristine E. Ensrud6,7,8, Douglas C. Bauer9, and for the Osteoporotic Fractures in Men (MrOS) Research Group Address all correspondence and requests for reprints to: Douglas C. Bauer, MD., Department of Medicine, San Francisco University Center, San Francisco, the United States of America , tel.: 415–514-8039, e-mail: DBauer@psg.ucsf.edu. DOI: http://dx.doi.org/10.1210/jc.2015-3191 Context: Both subclinic... περισσότερα »
Early changes in dynamic biomarkers of liver fibrosis in hepatitis C virus-infected patients treated with sofosbuvir
Chronic hepatitis C is a major cause of liver-associated mortality caused by decompensated cirrhosis and hepatocellular carcinoma. With the approval of sofosbuvir, therapeutic efficacy has markedly increased. Early changes in non-invasive biomarkers of liver fibrosis under effective antiviral therapy are widely unknown. from C via ola Kala on Inoreader http://ift.tt/1icCnBe via IFTTT
Synaptic Mechanisms Shaping Delay-Tuned Combination-Sensitivity in The Auditory Thalamus of Mustached Bats
Publication date: Available online 27 October 2015 *Source:*Hearing Research Author(s): John A. Butman, Nobuo Suga For the processing of target-distance information, delay-tuned auditory neurons of the mustached bat show facilitative responses to a combination of signal elements of a biosonar pulse-echo pair with a specific echo delay. They are initially produced in the inferior colliculus by facilitative responses based on the coincidence of the rebound response following glycinergic inhibition to the first harmonic of the pulse and a short-latency response to the 2nd–4th harmonics... περισσότερα »
Effect of a backboard on compression depth during cardiac arrest in the Emergency Department: A simulation study
The American Journal of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1H6WW8I via IFTTT
Reproductive hormone levels and all-cause, cancer and cardiovascular disease
The association of reproductive hormone levels and all-cause, cancer and cardiovascular disease mortality in menStine Agergaard Holmboe, et al. | The Journal of Clinical Endocrinology & Metabolism Stine Agergaard Holmboe1, Eleni Vradi2, Tina Kold Jensen1, Allan Linneberg3, 4,5,Lise Lotte N Husemoen3, Thomas Scheike2, Niels E Skakkebæk1, Anders Juul 1, and Anna-Maria Andersson1 Address all correspondence and requests for reprints to: Stine Agergaard Holmboe, MSc, University of Copenhagen, Dept. of Growth and Reproduction, GR-5064, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denma... περισσότερα »
Impact of early intervention on comprehensive language and academic achievement in Japanese hearing-impaired children with cochlear implants.
*Impact of early intervention on comprehensive language and academic achievement in Japanese hearing-impaired children with cochlear implants.* Int J Pediatr Otorhinolaryngol. 2015 Oct 8; Authors: Sugaya A, Fukushima K, Kasai N, Kataoka Y, Maeda Y, Nagayasu R, Toida N, Ohmori S, Fujiyoshi A, Taguchi T, Omichi R, Nishizaki K Abstract OBJECTIVES: Early hearing detection and intervention (EHDI) is critical for achievement of age-appropriate speech perception and language development in hearing-impaired children. It has been 15 years since newborn hearing screening (NHS) was introduc...περισσότερα »
Invasive Cervical Cancer and Antidepressants: A Nationwide Population-Based Study.
*Invasive Cervical Cancer and Antidepressants: A Nationwide Population-Based Study.* Medicine (Baltimore). 2015 Oct;94(42):e1866 Authors: Chan HL, Hsieh YH, Lin CF, Liang HY, Huang KY, Chiu WC, Lee Y, McIntyre RS, Chen VC Abstract To our knowledge, no prior population-based study has been published wherein the primary aim was to evaluate whether an association between psychotropic drug prescription and cervical cancer exists. Herein we have conducted the first study that primarily aimed to determine the association between antidepressants use and risk of invasive cervical cancer... περισσότερα »
Shale Gas Production Grows, Industry Benefits
[image: blog_mining_shale-gas_plastics_image4.jp] Shale gas deposits, or "plays," are contained in fine-grained sedimentary rocks that contain clay and other fine-grained minerals. Shale gas is difficult to extract because the low permeability and high clay content of the rock keeps the gas trapped inside. Hydraulic fracturing, (fracking), a technique of injecting water, sand, and chemicals into shale and other Read the rest of this article The post Shale Gas Production Grows, Industry Benefits appeared first on Accelerating Science. from Biomedical Engineering via ola Kala on ...περισσότερα »
Clinical Results of a Percutaneous Technique for Trigger Digit Release Using a 25-Gauge Hypodermic Needle Combined with Corticosteroid Infiltration
Publication date: Available online 23 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Yoshihiro Abe Clinical results of a technique of percutaneous needle trigger digit release (PNTDR) using a 25-gauge needle with corticosteroid infiltration are reported. This prospective study assessed 52 digits that underwent PNTDR. Results were compared with control group who had the only administration of steroid injection. Patients underwent PNTDR were divided into diabetic and nondiabetic groups and assessed postoperatively after 1 week, and after 1, 2, ... περισσότερα »
3D stereophotogrammetry in upper extremity lymphedema: an accurate diagnostic method
Publication date: Available online 22 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Marijn Hameeteman, Arico C. Verhulst, Rinaldo D. Vreeken, Thomas J.J. Maal, Dietmar J.O. Ulrich BackgroundUpper extremity lymphedema is a problem that is frequently seen after breast cancer treatment. Current diagnostic methods in volume measurement of the upper extremities are cumbersome or time consuming. The purpose of this study was to assess the validity and reliability of 3D stereophotogrammetry for volume measurements in upper extremity lymphedema.Meth... περισσότερα »
Modified ‘Mustardé’ Suture Technique: Novel way of inserting mattress sutures to create the antihelical fold
Publication date: Available online 22 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Log Murugesan, Kiera Welman, Daniel J. Marsh from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1LUXuk6 via IFTTT
Comparison between eyelid indices of ptotic eye and normal fellow eye in patients with unilateral congenital ptosis
Publication date: Available online 22 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Abbas Bagheri, Mehdi Tavakoli, Hadi Najmi, Reza Erfanian Salim, Shahin Yazdani PurposeTo evaluate the relationship between levator muscle function (LMF) and other eyelid parameters in the normal and affected eyes of patients with unilateral congenital ptosis.MethodsThis study includes subjects with unilateral congenital upper lid ptosis who were referred for operation over a 2-year period. Patients with other eyelid abnormalities and previous eyelid surgery w...περισσότερα »
Use of the Anterolateral Thigh Flap for Reconstruction of the Pediatric Anophthalmic Orbit
Publication date: Available online 22 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Sally L. Hynes, Christopher R. Forrest, Gregory H. Borschel Children with acquired anophthalmia pose unique reconstructive challenges. With implant-based reconstruction, the current standard of care, there is a tendency toward intraorbital and adnexal tissue contraction and an increasing volume discrepancy with orbital growth, producing enophthalmos, eyelid retraction, and difficulty retaining an ocular prosthesis. We describe a novel technique for secondary r... περισσότερα »
Immediate two-stage nipple reconstruction with a local mastectomy flap following secondary autologous breast reconstruction
Publication date: Available online 22 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Jinguang He, Tao Wang, Hua Xu, Yi Zhang, Jiasheng Dong Due to the inevitable postoperative shrinkage, an initial hypercorrection is emphasized in nipple reconstruction with a random skin flap. However, the breast shape will be damaged if an excessively large flap is raised on the surface of the breast mound. In the manuscript, we report a technique for immediate two-stage nipple reconstruction with a local mastectomy flap during the secondary breast reconstruc...περισσότερα »
Reply: “Composite Orbital Reconstruction Using the Vascularized Segmentalized Osteo-Fascio-Cutaneous Fibula Flap”
Publication date: Available online 22 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Daniel E. Borsuk from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1LUXi4m via IFTTT
Comment RE: Dynamic reconstruction of complex abdominal wall defects with the pedicled innervated vastus lateralis and anterolateral thigh PIVA flap
Publication date: Available online 22 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Sarita Vamadeva, Joannis Constantinides, Pari Mohanna, Paul Roblin, David Ross from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1Xw3fMs via IFTTT
A simple approach to facilitate the use of microdebrider for treatment of fibrous gynaecomastia
Publication date: Available online 21 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Sze-Ryn Chung, Terence Goh from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1N4IDHW via IFTTT
Evaluating the anatomical location of the posterior superior alveolar artery in cone beam computed tomography images
The purpose of this study was to examine the diameter, location, and frequency of the appearance of the posterior superior alveolar artery (PSAA) in preoperative cone beam computed tomography (CBCT) scans. Two hundred and eleven pre-implant CBCT scans were reviewed. The following criteria were considered in all subjects: (1) the location of the artery: intra-sinus or below the membrane (type I), intraosseous (type II), or superficial (type III); (2) the distance between the lower border of the artery and the alveolar crest; (3) the bone height measured from the floor of the sinus ... περισσότερα »
Journal of Craniofacial Surgery - Published Ahead-of-Print
- Assessing Patient-Reported Outcomes Following Orthognathic Surgery and Osseous Genioplasty.Schwitzer, Jonathan A.; Albino, Frank P.; Mathis, Ryan K.; Scott, Amie M.; Gamble, Laurie; Baker, Stephen B., 2015-10-21 07:00:00 AM Primary outcomes for orthognathic surgery and genioplasty patients include satisfaction with appearance, improved motor function, and enhanced quality of life. The goal of this study was to assess outcomes among patients undergoing these procedures, and to highlight the potential use of FACE-Q instrument for use in patients with dent... περισσότερα »
Wnt5a, Ryk and Ror2 Expression in Glioblastoma Subgroups
Publication date: Available online 26 October 2015 *Source:*Pathology - Research and Practice Author(s): Yuil Kim, Mineui Hong, In-Gu Do, Sang Yun Ha, Dakeun Lee, Yeon-Lim Suh BackgroundWnt5a, a non-canonical Wnt ligand, has been shown to play tumor-promoting or tumor-suppressive roles in different neoplasms. Increased Wnt5a expression and Wnt5a-dependent invasive activity that is mediated by one of its receptors, Ryk, have been reported in glioblastomas.MethodsWe investigated the protein expression of Wnt5a, its receptors Ryk and Ror2, and the canonical Wnt pathway marker β-catenin... περισσότερα »
Effect of resistance training on C-reactive protein, blood glucose and lipid profile in older women with differing levels of RT experience
Abstract The purpose of this study was to analyze the effects of a progressive resistance training (RT) program on C-reactive protein (CRP), blood glucose (GLU), and lipid profile in older women with differing levels of RT experience. Sixty-five older women (68.9 ± 6.1 years, 67.1 ± 13.1 kg) were separated according to RT experience: an advanced group composed by 35 participants who previously carried out 24 weeks of RT and a novice group composed by 30 participants without previous experience in RT (*n* = 30). Both groups performed a RT program comprised of eight exercises targeti... περισσότερα »
Andrologie in der Dermatologie – wozu?
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1H6VXFo via IFTTT
A genetic variant of p53 restricts the mucous secretory phenotype by regulating SPDEF and Bcl-2 expression.
[image: http:--http://ift.tt/1feGv2I] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *A genetic variant of p53 restricts the mucous secretory phenotype by regulating SPDEF and Bcl-2 expression.* Nat Commun. 2014;5:5567 Authors: Chand HS, Montano G, Huang X, Randell SH, Mebratu Y, Petersen H, Tesfaigzi Y Abstract Despite implications for carcinogenesis and other chronic diseases, basic mechanisms of p53 and its variants in suppressing Bcl-2 levels are poorly understood. Bcl-2 sustains mucous cell metaplasia, whereas p53(-/-) mice display chronically increased mucous cells... περισσότερα »
Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome.
*Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome.* J Laryngol Otol. 2015 Oct 26;:1 Authors: Bakshi SS PMID: 26498109 [PubMed - as supplied by publisher] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1icvhwz via IFTTT
Changes in the immunohistochemical localization of the glycine receptor in the superior olivary complex of adult circling mice.
*Changes in the immunohistochemical localization of the glycine receptor in the superior olivary complex of adult circling mice.* Mol Med Rep. 2015 Oct 13; Authors: Yoo YB, Maskey D, Kim MJ Abstract Circling mice is a mutant model of spontaneous deafness exhibiting degenerated spiral ganglion cells in the cochlea and loss of organ of Corti. The balance between glycinergic inhibition and glutamatergic excitation in the lateral superior olive (LSO) is essential for the detection of interaural level differences. Long term weakening of glycinergic synaptic inhibition in the LSO may ... περισσότερα »
A 'calcium capacitor' shapes cholinergic inhibition of cochlear hair cells.
[image: http:--media.wiley.com-assets-7278-93-Pu] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *A 'calcium capacitor' shapes cholinergic inhibition of cochlear hair cells.* J Physiol. 2014 Aug 15;592(Pt 16):3393-401 Authors: Fuchs PA Abstract Efferent cholinergic neurons project from the brainstem to inhibit sensory hair cells of the vertebrate inner ear. This inhibitory synapse combines the activity of an unusual class of ionotropic cholinergic receptor with that of nearby calcium-dependent potassium channels to shunt and hyperpolarize the hair cell. Postsynaptic calc... περισσότερα »
Omohyoid Muscle Syndrome in a Mixed Martial Arts Athlete: A Case Report.
*Omohyoid Muscle Syndrome in a Mixed Martial Arts Athlete: A Case Report.* Sports Health. 2015 Sep;7(5):458-462 Authors: Lee AD, Yu A, Young SB, Battaglia PJ, Ho CJ Abstract Omohyoid muscle syndrome is a rare cause of an X-shaped bulging lateral neck mass that occurs on swallowing. This is a diagnostic case report of a 22-year-old mixed martial arts athlete who acquired this condition. PMID: 26502424 [PubMed - as supplied by publisher] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1MoZO8D via IFTTT
High Risk of Lateral Nodal Metastasis in Lateral Solitary Solid Papillary Thyroid Cancer.
*High Risk of Lateral Nodal Metastasis in Lateral Solitary Solid Papillary Thyroid Cancer.* Ultrasound Med Biol. 2015 Oct 20; Authors: Lai XJ, Zhang B, Jiang YX, Li JC, Zhao RN, Yang X, Zhang Q, Zhang XY, Li WB, Zhu SL Abstract We explored the relationship between ultrasonic intra-thyroidal location and neck node metastasis pattern in solitary solid papillary thyroid cancer (PTC). Data on 186 patients were retrospectively reviewed. The association between several characteristics and neck node metastasis pattern were analyzed. Among the 186 thyroid nodules, age ≥45 y (p = 0.005),... περισσότερα »
Paranasal sinus opacification at MRI in lower airway disease (the HUNT study-MRI).
*Paranasal sinus opacification at MRI in lower airway disease (the HUNT study-MRI).* Eur Arch Otorhinolaryngol. 2015 Oct 26; Authors: Hansen AG, Helvik AS, Thorstensen WM, Nordgård S, Langhammer A, Bugten V, Stovner LJ, Eggesbø HB Abstract The study builds on the concept of united airways, which describes the link between the upper and lower airways. Explorations of this concept have mainly related to asthma and less to chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate paranasal sinus opacification at magnetic resonance imaging (MRI) in COPD,...περισσότερα »
Minor salivary gland carcinoma: a review of 35 cases.
*Minor salivary gland carcinoma: a review of 35 cases.* Eur Arch Otorhinolaryngol. 2015 Oct 23; Authors: Haymerle G, Schneider S, Harris L, Häupl T, Schopper C, Pammer J, Grasl MC, Erovic BM Abstract Minor salivary gland carcinomas represent a heterogeneous group of tumors with broad variation in clinical appearance and histopathology. Clinical data of patients with small salivary gland malignancies were collected from the medical records. Tissue microarray was constructed to determine the expression pattern of 24 proteins in 35 patients with minor salivary gland carcinomas. The... περισσότερα »
Long-Term Donor Site Morbidity after Vascularized Free Fibula Flap Harvesting: Clinical and Gait Analysis
Publication date: Available online 21 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Damien Feuvrier, Yoshimasa Sagawa, Samuel Béliard, Julien Pauchot, Pierre Decavel The goal of this study was to determine the clinical morbidity and changes in gait temporal spatial parameters after harvesting of a vascularized free fibula flap. Eleven patients (mean age: 52 ± 17 years) and eleven healthy controls (mean age: 50 ± 14 years) were included in this study. The patients were assessed between 5 and 104 months after their surgery. The study consisted...περισσότερα »
Ear and Hearing - Published Ahead-of-Print
- Asymmetric Hearing Loss in Chinese Workers Exposed to Complex Noise.Wang, Xiaoxiao; Li, Nan; Zeng, Lin; Tao, Liyuan; Zhang, Hua; Yang, Qiuling; Qiu, Wei; Zhu, Liangliang; Zhao, Yiming, 2015-10-23 07:00:00 AM Objectives: Evaluate the audiometric asymmetry in Chinese industrial workers and investigate the effects of noise exposure, sex, and binaural average thresholds on audiometric asymmetry. Design: Data collected from Chinese industrial workers during a cross-sectional study were reanalyzed. Of the 1388 workers, 266 met the inclusion criteria for this stud... περισσότερα »
British Journal of Dermatology
- Unilateral hyperhidrosis and hypothermia – symptoms of an intrathoracic tumourB. Dyring-Andersen, S. Kamp, A. Madelung, C. Zachariae, 2015-10-27 15:08:18 PM A 34-year old man presented at the Department of Dermato-allergology, Herlev and Gentofte Hospital with unilateral hyperhidrosis localized to the right axilla through approximately 10 years without progression of symptoms. The patient often experienced that his right hand was colder than the left, especially during bouts of hyperhidrosis. The symptoms usually arose in stressful situations. The patie... περισσότερα »
Three- and Four-Dimensional Breast Assessment
The Kinect Recording System for Objective Three- and Four-Dimensional Breast Assessment with Image Overlays via British Association of Plastic Surgeons Publication date: Available online 26 October 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Henseler Helga, Bonkat Sarah Kim, Vogt Peter, Rosenhahn Bodo IntroductionWe investigated the application of the validated portable Kinect camera for three-and fourdimensional breast assessment in female life models.MethodBreast images from six life models were captured using the Kinect camera. Capture was conducte... περισσότερα »
The Egyptian Journal of Otolaryngology
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 4 ώρες
- A comparative study of the efficacy of topical nasal steroids versus systemic steroids in the treatment of otitis media with effusion in childrenMohamed Anwar, 2015-10-27 00:00:00 AM *Mohamed Anwar, Mosaad Abdel-Aziz, Ahmad Nassar, Tamer Ismail* The Egyptian Journal of Otolaryngology 2015 31(4):208-212 Objective To evaluate the effectiveness of using topical nasal steroids versus oral steroids in the treatment of otitis media with effusion (OME) in children. Methods One hundred (100) patients were included in the study, they were divided into two ... περισσότερα »
Mycoses
- Identification of invasive fungal diseases in immunocompromised patients by combining an Aspergillus specific PCR with a multifungal DNA-microarray from primary clinical samplesT. Boch, M. Reinwald, P. Postina, O. A. Cornely, J. J. Vehreschild, C. P. Heußel, W. J. Heinz, M. Hoenigl, S. Eigl, T. Lehrnbecher, J. Hahn, B. Claus, M. Lauten, G. Egerer, M. C. Müller, S. Will, N. Merker, W.-K. Hofmann, D. Buchheidt, B. Spiess, 2015-10-27 15:01:12 PM Summary The increasing incidence of invasive fungal diseases (IFD), most of all invasive aspergillosis (IA) i... περισσότερα »
Journal of Research in Medical Sciences
- Effect of the peels of two Citrus fruits on endothelium function in adolescents with excess weight: A triple-masked randomized trialMohammad Hashemi, 2015-10-27 00:00:00 AM *Mohammad Hashemi, Elham Khosravi, Alireza Ghannadi, Mahin Hashemipour, Roya Kelishadi* Journal of Research in Medical Sciences 2015 20(8):721-726 Background: Obesity induces endothelial dysfunction even in the pediatric age group. The possible protective effects of fruits and herbal products on the endothelial dysfunction of obese children remain to be determined. This stu... περισσότερα »
Olanzapine long-acting injection: a review of first experiences of post-injection delirium/sedation syndrome in routine clinical practice.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Olanzapine long-acting injection: a review of first experiences of post-injection delirium/sedation syndrome in routine clinical practice.* BMC Psychiatry. 2015;15:65 Authors: Bushe CJ, Falk D, Anand E, Casillas M, Perrin E, Chhabra-Khanna R, Detke HC Abstract BACKGROUND: Olanzapine long-acting injection (LAI) for the treatment of schizophrenia was associated with a cluster of symptoms termed post-injection delirium/sedation syndrome (PDSS) in a small percentage (~2%) of patients during...περισσότερα »
Amarogentin Displays Immunomodulatory Effects in Human Mast Cells and Keratinocytes
Keratinocytes express the bitter taste receptors TAS2R1 and TAS2R38. Amarogentin as an agonist for TAS2R1 and other TAS2Rs promotes keratinocyte differentiation. Similarly, mast cells are known to express bitter taste receptors. The aim of this study was to assess whether bitter compounds display immunomodulatory effects on these immunocompetent cells in the skin, so that they might be a target in chronic inflammatory diseases such as atopic dermatitis and psoriasis. Here, we investigated the impact of amarogentin on substance P-induced release of histamine and TNF-α from the huma...περισσότερα »
Usefulness of 18 F-FDG PET/CT to Detect Metastatic Mucinous Adenocarcinoma Within an Inguinal Hernia
Abstract Metastatic mucinous adenocarcinoma in an inguinal hernia is a rare disease and the image findings of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) are little known. Here, we introduce a 57-year-old man with metastatic mucinous adenocarcinoma in an inguinal hernia. On initial 18F-FDG PET/CT, hypermetabolism was observed in mucinous adenocarcinoma of the cecum, and adenocarcinomas of the transverse and ascending colon, respectively. Follow-up 18F-FDG PET/CT revealed newly developed multiple hypermetabolism in peritoneal seeding ... περισσότερα »
Mitoxantrone as a contributing factor in medication-related osteonecrosis of the jaws
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is usually initiated by dental surgery, but is occasionally exacerbated by other antiresorptive (denosumab) and anti-angiogenic therapies, and in such cases is currently termed medication-related osteonecrosis of the jaws (MRONJ). The case of a 58-year-old female with breast cancer who developed multiple and ultimately fatal metastases despite 3 years of treatment with chemotherapeutic drugs and intravenous bisphosphonates, is presented herein. from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1XvR6qK via IFTTT
Prenatal testosterone and stuttering.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Prenatal testosterone and stuttering.* Early Hum Dev. 2015 Jan;91(1):43-6 Authors: Montag C, Bleek B, Breuer S, Prüss H, Richardt K, Cook S, Yaruss JS, Reuter M Abstract BACKGROUND: The prevalence of stuttering is much higher in males compared to females. The biological underpinnings of this skewed sex-ratio is poorly understood, but it has often been speculated that sex hormones could play an important role. AIMS: The present study investigated a potential link between prenatal testosterone and stuttering. Here,...περισσότερα »
Disfluency: it is not always stuttering.
[image: http:--media.wiley.com-assets-2250-98-Wi] Related Articles *Disfluency: it is not always stuttering.* Clin Genet. 2014 Mar;85(3):298-9 Authors: Cosyns M, van Zaalen Y, Mortier G, Janssens S, Amez A, Van Damme J, Van Borsel J PMID: 23565840 [PubMed - indexed for MEDLINE] from Language and Communication Disorders via ola Kala on Inoreader http://ift.tt/1icgxOg via IFTTT
Innovative Physics and Engineering Research in Nuclear Medicine and Molecular Imaging : A Message from the Associate Editor
from Cancer via ola Kala on Inoreader http://ift.tt/1WfBSDK via IFTTT
Intensity modulated perioperative HDR brachytherapy for recurrent and/or advanced head and neck metastases.
*Intensity modulated perioperative HDR brachytherapy for recurrent and/or advanced head and neck metastases.* Eur Arch Otorhinolaryngol. 2015 Oct 23; Authors: Teudt IU, Kovàcs G, Ritter M, Melchert C, Soror T, Wollenberg B, Meyer JE Abstract Recurrent neck metastases following surgery and full dose adjuvant radiotherapy of squamous cell head and neck cancer remain a clinical challenge. After revision neck dissection and chemotherapy re-irradiation dosage is often limited and survival prognosis deteriorates. Here, adjuvant high-dose rate intensity modulated perioperative brachyth... περισσότερα »
Reconstructive approach to hostile cranioplasty: A review of the University of Chicago experience.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Reconstructive approach to hostile cranioplasty: A review of the University of Chicago experience.* J Plast Reconstr Aesthet Surg. 2015 Aug;68(8):1036-43 Authors: Fong AJ, Lemelman BT, Lam S, Kleiber GM, Reid RR, Gottlieb LJ Abstract BACKGROUND: Hostile sites for cranioplasty occur in patients with a history of radiation, infection, failed cranioplasty, CSF leak or acute infection. We review our series of autologous cranioplasties and present an approach to decision-making for reconstructing these complex defects....περισσότερα »
Cochlear implantation for hearing rehabilitation in single-sided deafness after translabyrinthine vestibular schwannoma surgery.
*Cochlear implantation for hearing rehabilitation in single-sided deafness after translabyrinthine vestibular schwannoma surgery.* Eur Arch Otorhinolaryngol. 2015 Oct 23; Authors: Hassepass F, Arndt S, Aschendorff A, Laszig R, Wesarg T Abstract The aim of the study was to investigate the option of cochlear implantation (CI) in resultant single-sided deafness associated with unilateral translabyrinthine resection of sporadic vestibular schwannoma (VS). This is a retrospective study performed at Tertiary Care Academic Centre. Following extensive counselling regarding the potential ... περισσότερα »
Repeated sessions of transcranial direct current stimulation for treatment of chronic subjective tinnitus: a pilot randomized controlled trial.
*Repeated sessions of transcranial direct current stimulation for treatment of chronic subjective tinnitus: a pilot randomized controlled trial.* Neurol Sci. 2015 Oct 24; Authors: Forogh B, Mirshaki Z, Raissi GR, Shirazi A, Mansoori K, Ahadi T Abstract Subjective tinnitus is an auditory phantom sensation characterized by the perception of sound in the absence of an identifiable external source. This distressing audiological symptom can severely affect the quality of life. Transcranial direct current stimulation (tDCS) is a noninvasive technique that can induce short-term relief i... περισσότερα »
Incidence of Retrocochlear Pathology Found on MRI in Patients With Non-Pulsatile Tinnitus.
*Incidence of Retrocochlear Pathology Found on MRI in Patients With Non-Pulsatile Tinnitus.* Otol Neurotol. 2015 Oct 22; Authors: Choi KJ, Sajisevi MB, Kahmke RR, Kaylie DM Abstract OBJECTIVE: To identify the incidence of retrocochlear pathology on MRI in patients with non-pulsatile tinnitus. STUDY DESIGN: Retrospective review. SETTING: Tertiary Referral Center. PATIENTS: Adults with MRIs performed between March 1, 2008 and February 1, 2014 for non-pulsatile tinnitus with or without hearing loss. INTERVENTION: MRI. MAIN OUTCOME MEASURE: Incidence of retrocochlear pathology. RESULTS... περισσότερα »
Hearing Aid Use and Associated Factors in South Korea.
*Hearing Aid Use and Associated Factors in South Korea.* Medicine (Baltimore). 2015 Oct;94(42):e1580 Authors: Moon IJ, Baek SY, Cho YS Abstract Despite the high prevalence of hearing impairment in the elderly, the rate of hearing aid use is still low. The objectives of this study were to report the nation-wide prevalence of hearing aid use in the Korean population and to determine the associated factors with hearing aid use utilizing a nationally representative data set.We obtained data from the 2010 to 2012 Korea National Health and Nutrition Examination Surveys, which were cro... περισσότερα »
Open surgical management of oesophageal diverticulum.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Open surgical management of oesophageal diverticulum.* Multimed Man Cardiothorac Surg. 2015;2015 Authors: Gust L, De Lesquen H, Ouattara M, Thomas PA, D'Journo XB Abstract Epiphrenic diverticula are defined as the herniation of the mucosa and submucosa through the muscular layers of the oesophageal wall in its lower third. An increased intraluminal pressure associated with an oesophageal motility disorder is usually present in the pathophysiology of the disease. Surgical treatment is indicated mostly in symptomati...περισσότερα »
[Palsy of CVI caused by ecchordosis physaliphora].
*[Palsy of CVI caused by ecchordosis physaliphora].* Ophthalmologe. 2015 Oct 26; Authors: Stahl-Hoffmann VD, Gräf M, Cesnulis E, Schuknecht B, Lorenz B Abstract We report a case of symptomatic ecchordosis physaliphora (EP) in a 34-year-old woman who presented with progressive diplopia due to palsy of the left sixth cranial nerve. Repeated magnetic resonance imaging (MRI) disclosed typical characteristics of a congenital EP lesion with compression of the left abducens nerve presumably because of a secondary herniation of the arachnoid mater. We performed an augmenting combined re...περισσότερα »
Pediatric sleep-disordered breathing: New evidence on its development.
*Pediatric sleep-disordered breathing: New evidence on its development.* Sleep Med Rev. 2015 Dec;24:46-56 Authors: Guilleminault C, Akhtar F Abstract Sleep-disordered breathing (SDB) in children could be resolved by adenotonsillectomy (T&A). However, incomplete results are often noted post-surgery. Because of this partial resolution, long-term follow-up is needed to monitor for reoccurrence of SDB, which may be diagnosed years later through reoccurrence of complaints or in some cases, through systematic investigations. Children undergoing T&A often have small upper airways. Gene...περισσότερα »
Initial experience with dual-lumen balloon catheter injection for preoperative Onyx embolization of skull base paragangliomas.
*Initial experience with dual-lumen balloon catheter injection for preoperative Onyx embolization of skull base paragangliomas.* J Neurosurg. 2015 Oct 23;:1-7 Authors: Ladner TR, He L, Davis BJ, Yang GL, Wanna GB, Mocco J Abstract OBJECT Paragangliomas are highly vascular head and neck tumors for which preoperative embolization is often considered to facilitate resection. The authors evaluated their initial experience using a dual-lumen balloon to facilitate preoperative embolization in 5 consecutive patients who underwent preoperative transarterial Onyx embolization assisted by ... περισσότερα »
Esophageal motility after peroral endoscopic myotomy for achalasia.
*Esophageal motility after peroral endoscopic myotomy for achalasia.* J Gastroenterol. 2015 Oct 25; Authors: Hu Y, Li M, Lu B, Meng L, Fan Y, Bao H Abstract BACKGROUND: Peroral endoscopic myotomy (POEM) has been introduced as a novel endoscopic treatment for achalasia. The aim of this work is to assess the changes in esophageal motility caused by POEM in patients with achalasia. METHODS: Forty-one patients with achalasia underwent POEM from September 2012 to November 2014. Esophageal motility of all patients was evaluated preoperatively and 1 month after POEM utilizing high-resol... περισσότερα »
Discordance of histopathologic parameters in cutaneous melanoma: Clinical implications
Histopathologic analysis remains the gold standard for the diagnosis of melanoma, however previous studies have shown a substantial rate of interobserver variability in the evaluation of melanocytic lesions. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1Rc91z3 via IFTTT
Incidence and treatment patterns of complicated bone metastases in a population-based radiotherapy program
There is abundant evidence in support of single fraction (SF) radiation therapy (RT) for uncomplicated bone metastases (BoM). We sought to determine the proportion of BoM that is complicated in a population-based RT program in order to act as a potential guide for assessing SFRT utilization rates. from Rathiotherapy via ola Kala on Inoreader http://ift.tt/1Rc3Peo via IFTTT
Psoriasis pustulosa generalizada
Publication date: November 2015 *Source:*Piel, Volume 30, Issue 9 Author(s): Adrián Imbernón-Moya, Marcela Martínez-Pérez, Alejandro Lobato-Berezo, Micaela Churruca-Grijelmo, Antonio Aguilar-Martínez, Miguel Ángel Gallego-Valdés from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1MoJ1SV via IFTTT
Etiopatogenia del carcinoma basocelular. Vías genéticas y dianas terapéuticas
Publication date: November 2015 *Source:*Piel, Volume 30, Issue 9 Author(s): José Suárez Hernández, Ricard Fernández-de-Misa Cabrera from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1MoJ2Xb via IFTTT
Síndrome LEOPARD
Publication date: November 2015 *Source:*Piel, Volume 30, Issue 9 Author(s): Adrián Imbernón-Moya, Micaela Churruca-Grijelmo, Alejandro Lobato-Berezo, Carmen Lacambra from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1MoJ2X2 via IFTTT
Lesiones marfileñas en el tronco y la mano izquierda
Publication date: November 2015 *Source:*Piel, Volume 30, Issue 9 Author(s): Alejandro Lobato-Berezo, Montserrat Chao-Crecente, Antonio Aguilar-Martínez from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1MoJ2GC via IFTTT
Mácula negra en la nuca
Publication date: November 2015 *Source:*Piel, Volume 30, Issue 9 Author(s): Enric Piqué-Duran, Odalys García-Vazquez, Miguel A. Azcue-Mayorga from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1Wfq58r via IFTTT
Lesiones marfileñas en el tronco y la mano izquierda. Diagnóstico y comentario
Publication date: November 2015 *Source:*Piel, Volume 30, Issue 9 Author(s): Alejandro Lobato-Berezo, Montserrat Chao-Crecente, Antonio Aguilar-Martínez from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1Wfq4l7 via IFTTT
Mácula negra en la nuca. Diagnóstico y comentario
Publication date: November 2015 *Source:*Piel, Volume 30, Issue 9 Author(s): Enric Piqué-Duran, Odalys García-Vazquez, Miguel A. Azcue-Mayorga from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1MoJ1lU via IFTTT
Options for Auditory Training for Adults with Hearing Loss
Semin Hear 2015; 36: 284-295 DOI: 10.1055/s-0035-1564461 Hearing aid devices alone do not adequately compensate for sensory losses despite significant technological advances in digital technology. Overall use rates of amplification among adults with hearing loss remain low, and overall satisfaction and performance in noise can be improved. Although improved technology may partially address some listening problems, auditory training may be another alternative to improve speech recognition in noise and satisfaction with devices. The literature underlying auditory plasticity followin... περισσότερα »
Auditory Training for Central Auditory Processing Disorder
Semin Hear 2015; 36: 199-215 DOI: 10.1055/s-0035-1564458 Auditory training (AT) is an important component of rehabilitation for patients with central auditory processing disorder (CAPD). The present article identifies and describes aspects of AT as they relate to applications in this population. A description of the types of auditory processes along with information on relevant AT protocols that can be used to address these specific deficits is included. Characteristics and principles of effective AT procedures also are detailed in light of research that reflects on their value. F... περισσότερα »
The Effects of Meaning-Based Auditory Training on Behavioral Measures of Perceptual Effort in Individuals with Impaired Hearing
Semin Hear 2015; 36: 263-272 DOI: 10.1055/s-0035-1564454 There has been considerable interest in measuring the perceptual effort required to understand speech, as well as to identify factors that might reduce such effort. In the current study, we investigated whether, in addition to improving speech intelligibility, auditory training also could reduce perceptual or listening effort. Perceptual effort was assessed using a modified version of the n-back memory task in which participants heard lists of words presented without background noise and were asked to continually update thei... περισσότερα »
Cephalalgia
Cephalalgia -- Preview Articles - The influence of genetic constitution on migraine drug responsesChristensen, A. F., Esserlind, A.-L., Werge, T., Stefansson, H., Stefansson, K., Olesen, J., 2015-10-27 08:56:05 AM Objective Specific acute treatments of migraine are 5HT1B/D receptor agonists; triptans and ergotamine, but only two-thirds of patients respond well without side effects. No migraine-prophylactic drugs are specific to migraine. Prophylactic drugs are selected by time-consuming "trial and error." Personalized treatment is therefore much needed. The... περισσότερα »
Transbronchial Cryobiopsies in the Evaluation of Lung Allografts: Do the Benefits Outweigh the Risks?
[image: http:--allenpress.com-system-files-image] Related Articles *Transbronchial Cryobiopsies in the Evaluation of Lung Allografts: Do the Benefits Outweigh the Risks?* Arch Pathol Lab Med. 2015 Oct 21; Authors: Roden AC, Kern RM, Aubry MC, Jenkins SM, Yi ES, Scott JP, Maldonado F Abstract Context .- Transbronchial cryobiopsy technique yields larger biopsies with enhanced quality. The benefits and safety of cryobiopsies have not been thoroughly studied in lung allografts. Objective . -To compare size, quality, reproducibility of interpretation of rejection and complications of... περισσότερα »
Practical Applications in Immunohistochemistry: Carcinomas of Unknown Primary Site.
[image: http:--allenpress.com-system-files-image] Related Articles *Practical Applications in Immunohistochemistry: Carcinomas of Unknown Primary Site.* Arch Pathol Lab Med. 2015 Oct 12; Authors: Kandalaft PL, Gown AM Abstract Context .- Identification of the site of origin of carcinoma of unknown primary using immunohistochemistry is a frequent requirement of anatomic pathologists. Diagnostic accuracy is crucial, particularly in the current era of targeted therapies and smaller sample sizes. Objectives .- To provide practical guidance and suggestions for classifying carcinoma of...περισσότερα »
Employer Expectations for Newly Trained Pathologists: Report of a Survey From the Graduate Medical Education Committee of the College of American Pathologists.
[image: http:--allenpress.com-system-files-image] Related Articles *Employer Expectations for Newly Trained Pathologists: Report of a Survey From the Graduate Medical Education Committee of the College of American Pathologists.* Arch Pathol Lab Med. 2015 Oct 2; Authors: Post MD, Johnson K, Brissette MD, Conran RM, Domen RE, Hoffman RD, McCloskey CB, Raciti PM, Roberts CA, Rojiani AM, Tucker JA, Powell SZ Abstract Context .- Multiple sources have identified challenges that training programs face in preparing graduates for the "real world" practice of pathology, and many training p...περισσότερα »
Validation of the Lung Subtyping Panel in Multiple Fresh-Frozen and Formalin-Fixed, Paraffin-Embedded Lung Tumor Gene Expression Data Sets.
[image: http:--allenpress.com-system-files-image] Related Articles *Validation of the Lung Subtyping Panel in Multiple Fresh-Frozen and Formalin-Fixed, Paraffin-Embedded Lung Tumor Gene Expression Data Sets.* Arch Pathol Lab Med. 2015 Oct 2; Authors: Faruki H, Mayhew GM, Fan C, Wilkerson MD, Parker S, Kam-Morgan L, Eisenberg M, Horten B, Hayes DN, Perou CM, Lai-Goldman M Abstract Context .- A histologic classification of lung cancer subtypes is essential in guiding therapeutic management. Objective .- To complement morphology-based classification of lung tumors, a previously devel... περισσότερα »
Next-Generation Sequencing of a Cohort of Pulmonary Large Cell Carcinomas Reclassified by World Health Organization 2015 Criteria.
[image: http:--allenpress.com-system-files-image] Related Articles *Next-Generation Sequencing of a Cohort of Pulmonary Large Cell Carcinomas Reclassified by World Health Organization 2015 Criteria.* Arch Pathol Lab Med. 2015 Oct 2; Authors: Driver BR, Portier BP, Mody DR, Deavers M, Bernicker EH, Kim MP, Teh BS, Santacruz JF, Kopas L, Munden RF, Cagle PT Abstract Context .- The classification of pulmonary large cell carcinoma has undergone a major revision with the recent World Health Organization (WHO) 2015 Classification. Many large cell carcinomas are now reassigned to either... περισσότερα »
Abstracts and Case Studies From the College of American Pathologists 2015 Annual Meeting (CAP '15).
[image: http:--allenpress.com-system-files-image] Related Articles *Abstracts and Case Studies From the College of American Pathologists 2015 Annual Meeting (CAP '15).* Arch Pathol Lab Med. 2015 Oct;139(10):e2-e186 Authors: PMID: 26414477 [PubMed - in process] from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1MowO0D via IFTTT
Abstract/Case Study Review Committee for the College of American Pathologists 2015 Annual Meeting.
[image: http:--allenpress.com-system-files-image] Related Articles *Abstract/Case Study Review Committee for the College of American Pathologists 2015 Annual Meeting.* Arch Pathol Lab Med. 2015 Oct;139(10):e1 Authors: Abstract The Archives of Pathology & Laboratory Medicine acknowledges the following individuals for volunteering to review abstract and case study submissions for the CAP '15 meeting. PMID: 26414476 [PubMed - in process] from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1XvwiQl via IFTTT
Acute Promyelocytic Leukemia: A Review and Discussion of Variant Translocations.
[image: http:--allenpress.com-system-files-image] Related Articles *Acute Promyelocytic Leukemia: A Review and Discussion of Variant Translocations.* Arch Pathol Lab Med. 2015 Oct;139(10):1308-13 Authors: Adams J, Nassiri M Abstract The majority of patients with acute promyelocytic leukemia (APL) manifest the t(15;17)(q24.1;q21.2) translocation; however, a minor but significant proportion of patients with APL harbor complex, cryptic, or variant translocations, which typically involve RARA. With the exception of ZBTB16/RARA, these variants have similar morphologic and immunophenot...περισσότερα »
Underutilization of Meta-analysis in Diagnostic Pathology.
[image: http:--allenpress.com-system-files-image] Related Articles *Underutilization of Meta-analysis in Diagnostic Pathology.* Arch Pathol Lab Med. 2015 Oct;139(10):1302-7 Authors: Kinzler M, Zhang L Abstract Context .- No studies to our knowledge have investigated citations and utilization of meta-analysis in diagnostic pathology (DP). Objective .- To characterize meta-analyses in DP compared with meta-analyses in medicine. Design .- We searched PubMed for meta-analyses in 12 major DP journals without specifying years and in 4 major medicine journals in both 2006 and 2011. We c...περισσότερα »
Assessing the Impact of Analytical Error on Perceived Disease Severity.
[image: http:--allenpress.com-system-files-image] Related Articles *Assessing the Impact of Analytical Error on Perceived Disease Severity.* Arch Pathol Lab Med. 2015 Oct;139(10):1295-301 Authors: Kroll MH, Garber CC, Bi C, Suffin SC Abstract Context .- The perception of the severity of disease from laboratory results assumes that the results are free of analytical error; however, analytical error creates a spread of results into a band and thus a range of perceived disease severity. Objective .- To assess the impact of analytical errors by calculating the change in perceived dise... περισσότερα »
Atypical Spitz Tumors: A Diagnostic Challenge.
[image: http:--allenpress.com-system-files-image] Related Articles *Atypical Spitz Tumors: A Diagnostic Challenge.* Arch Pathol Lab Med. 2015 Oct;139(10):1263-70 Authors: Harms KL, Lowe L, Fullen DR, Harms PW Abstract Spitzoid melanocytic lesions encompass a spectrum from benign Spitz nevi to malignant spitzoid melanomas. Spitzoid melanocytic neoplasms have significant morphologic and molecular differences from conventional melanocytic lesions, and prediction of biologic behavior and metastatic risk may be difficult. Most challenging is the atypical Spitz tumor, a borderline spit...περισσότερα »
Pulmonary Apical Cap-What's Old Is New Again.
[image: http:--allenpress.com-system-files-image] Related Articles *Pulmonary Apical Cap-What's Old Is New Again.* Arch Pathol Lab Med. 2015 Oct;139(10):1258-62 Authors: Lagstein A Abstract The pulmonary apical cap (PAC) is a morphologically distinct type of unilateral or bilateral fibroelastotic scar involving the lung apices. Despite being relatively common and having been described more than a hundred years ago, it remains underappreciated as a unique diagnostic entity by clinicians, radiologists, and pathologists alike. Given the centrality of modern chest imaging in the work...περισσότερα »
Morphologic Mimics of Invasive Lobular Carcinoma.
[image: http:--allenpress.com-system-files-image] Related Articles *Morphologic Mimics of Invasive Lobular Carcinoma.* Arch Pathol Lab Med. 2015 Oct;139(10):1253-7 Authors: Ishikawa MK, Pinsky RW, Smith LB, Jorns JM Abstract Invasive lobular carcinoma of the breast is a relatively common diagnosis. However, other carcinomatous as well as noncarcinomatous neoplasms, either primary or metastatic to the breast, may mimic invasive lobular carcinoma. As treatment may differ, establishing the correct diagnosis is paramount to providing the appropriate care for these patients. This revie... περισσότερα »
Metastases to the Pancreas Encountered on Endoscopic Ultrasound-Guided, Fine-Needle Aspiration.
[image: http:--allenpress.com-system-files-image] Related Articles *Metastases to the Pancreas Encountered on Endoscopic Ultrasound-Guided, Fine-Needle Aspiration.* Arch Pathol Lab Med. 2015 Oct;139(10):1248-52 Authors: Pang JC, Roh MH Abstract Metastatic lesions in the pancreas are very uncommon and may be difficult to differentiate from the more commonly encountered primary neoplasms derived from the exocrine and endocrine pancreas because of the significant overlap in clinical presentation, imaging, and cytologic features. Metastasis to the pancreas may occur years after treat... περισσότερα »
Olmesartan-Associated Enteropathy: A Review of Clinical and Histologic Findings.
[image: http:--allenpress.com-system-files-image] Related Articles *Olmesartan-Associated Enteropathy: A Review of Clinical and Histologic Findings.* Arch Pathol Lab Med. 2015 Oct;139(10):1242-7 Authors: Choi EY, McKenna BJ Abstract Olmesartan is an antihypertensive medication belonging to the angiotensin II receptor blocker class of drugs that has recently been associated with severe enteropathy. Olmesartan-associated enteropathy is uncommon and may be difficult to recognize because of its clinical and histologic similarities to other clinical entities, including celiac sprue an... περισσότερα »
Intraductal Carcinoma of the Prostate: Morphologic Features, Differential Diagnoses, Significance, and Reporting Practices.
[image: http:--allenpress.com-system-files-image] Related Articles *Intraductal Carcinoma of the Prostate: Morphologic Features, Differential Diagnoses, Significance, and Reporting Practices.* Arch Pathol Lab Med. 2015 Oct;139(10):1234-41 Authors: Magers M, Kunju LP, Wu A Abstract The differential diagnosis for atypical cribriform lesions of the prostate has become increasingly complex and includes intraductal carcinoma of the prostate, high-grade prostatic intraepithelial neoplasia, and atypical intraductal proliferations. In this review, we summarize the morphologic and molecul... περισσότερα »
MiT Family Translocation-Associated Renal Cell Carcinoma: A Contemporary Update With Emphasis on Morphologic, Immunophenotypic, and Molecular Mimics.
[image: http:--allenpress.com-system-files-image] Related Articles *MiT Family Translocation-Associated Renal Cell Carcinoma: A Contemporary Update With Emphasis on Morphologic, Immunophenotypic, and Molecular Mimics.* Arch Pathol Lab Med. 2015 Oct;139(10):1224-33 Authors: Magers MJ, Udager AM, Mehra R Abstract Translocation-associated renal cell carcinoma (t-RCC) is a relatively uncommon subtype of renal cell carcinoma characterized by recurrent gene rearrangements involving the TFE3 or TFEB loci. TFE3 and TFEB are members of the microphthalmia transcription factor (MiT) family,... περισσότερα »
Acute Myeloid Leukemia Genetics: Risk Stratification and Implications for Therapy.
[image: http:--allenpress.com-system-files-image] Related Articles *Acute Myeloid Leukemia Genetics: Risk Stratification and Implications for Therapy.* Arch Pathol Lab Med. 2015 Oct;139(10):1215-23 Authors: Wang ML, Bailey NG Abstract Acute myeloid leukemia is a category of diseases with a common aggressive clinical presentation but with a prognosis and management that is dependent upon the underlying genetic characteristics of the neoplasm. The purpose of this brief review is to update the practicing pathologist on the current standard of care in the genetic evaluation of acute ... περισσότερα »
Modified Occlusal Table - An Aid to Enhance Function of Hemimandibulectomy Patient: A Case Report.
*Modified Occlusal Table - An Aid to Enhance Function of Hemimandibulectomy Patient: A Case Report.* J Clin Diagn Res. 2015 Sep;9(9):ZD01-ZD03 Authors: Shashidhara HS, Thippanna RK, Dang K, Hajira N, Sharma A Abstract Completely edentulous patients who have undergone hemimandibulectomy suffer severe anatomic and functional loss. Functions like mastication, speech and deglutition are severely compromised. The mandibular deviation towards the resected side leads to inefficient mastication. In order to alleviate the difficulties encountered by the patient, construction of a modified...περισσότερα »
Clinical Variables Associated with Hydration Status in Acute Ischemic Stroke Patients with Dysphagia.
*Clinical Variables Associated with Hydration Status in Acute Ischemic Stroke Patients with Dysphagia.* Dysphagia. 2015 Oct 23; Authors: Crary MA, Carnaby GD, Shabbir Y, Miller L, Silliman S Abstract Acute stroke patients with dysphagia are at increased risk for poor hydration. Dysphagia management practices may directly impact hydration status. This study examined clinical factors that might impact hydration status in acute ischemic stroke patients with dysphagia. A retrospective chart review was completed on 67 ischemic stroke patients who participated in a prior study of nutr...περισσότερα »
Modified Occlusal Table - An Aid to Enhance Function of Hemimandibulectomy Patient: A Case Report.
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 7 ώρες
*Modified Occlusal Table - An Aid to Enhance Function of Hemimandibulectomy Patient: A Case Report.* J Clin Diagn Res. 2015 Sep;9(9):ZD01-ZD03 Authors: Shashidhara HS, Thippanna RK, Dang K, Hajira N, Sharma A Abstract Completely edentulous patients who have undergone hemimandibulectomy suffer severe anatomic and functional loss. Functions like mastication, speech and deglutition are severely compromised. The mandibular deviation towards the resected side leads to inefficient mastication. In order to alleviate the difficulties encountered by the patient, construction of a modified...περισσότερα »
Clinical Variables Associated with Hydration Status in Acute Ischemic Stroke Patients with Dysphagia.
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 7 ώρες
*Clinical Variables Associated with Hydration Status in Acute Ischemic Stroke Patients with Dysphagia.* Dysphagia. 2015 Oct 23; Authors: Crary MA, Carnaby GD, Shabbir Y, Miller L, Silliman S Abstract Acute stroke patients with dysphagia are at increased risk for poor hydration. Dysphagia management practices may directly impact hydration status. This study examined clinical factors that might impact hydration status in acute ischemic stroke patients with dysphagia. A retrospective chart review was completed on 67 ischemic stroke patients who participated in a prior study of nutr...περισσότερα »
Abordaje terapéutico del carcinoma escamoso cutáneo no operable
Publication date: November 2015 *Source:*Piel, Volume 30, Issue 9 Author(s): Rafael Salido Vallejo, Gloria Garnacho Saucedo, Carmen María Alcántara Reifs, Antonio Vélez García-Nieto from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1MoJ29v via IFTTT
Psoriasis desarrollada en estrías de distensión: fenómeno de Koebner inusual en un paciente con psoriasis tratada con ustekinumab
Publication date: November 2015 *Source:*Piel, Volume 30, Issue 9 Author(s): Benigno Monteagudo, Ana Varela-Veiga, Alejandro Vilas-Sueiro, Daniel González-Vilas from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1LUcqyU via IFTTT
Aparición de quistes de milium sobre un tatuaje
Publication date: November 2015 *Source:*Piel, Volume 30, Issue 9 Author(s): Susana Córdoba, Nieves Puente, Cristina Martínez-Morán, Jesús M. Borbujo from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1PRrimD via IFTTT
Empeoramiento repentino de una dermatitis herpetiforme bien tratada: siguiendo la pista
Publication date: November 2015 *Source:*Piel, Volume 30, Issue 9 Author(s): María Encarnación Gómez Sánchez, Eduardo Escario Travesedo, Maria Teresa López Villaescusa, Fernando de Manueles Marcos from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1PRri69 via IFTTT
Síndrome de Sweet localizado tras cirugía de carcinoma de células de Merkel
Publication date: November 2015 *Source:*Piel, Volume 30, Issue 9 Author(s): Sergio Santos-Alarcón, Tania Díaz-Corpas, Almudena Mateu-Puchades, Amparo Fuertes-Prósper from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1LUcsa0 via IFTTT
Leishmaniasis cutánea en un niño tratado con éxito con fluconazol oral
Publication date: November 2015 *Source:*Piel, Volume 30, Issue 9 Author(s): Clara Martín-Callizo from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1LUcpeg via IFTTT
Seguridad y utilidad de la fototerapia con rayos ultravioleta B de banda estrecha en la edad pediatrica
Publication date: Available online 26 October 2015 *Source:*Piel Author(s): María del Mar Escudero, Juan Escalas from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1PRrhzl via IFTTT
Seasonal, interannual, and long-term variabilities in biomass burning activity over South Asia
Abstract The seasonal, interannual, and long-term variations in biomass burning activity and related emissions are not well studied over South Asia. In this regard, active fire location retrievals from the Moderate Resolution Imaging Spectroradiometer (MODIS), the retrievals of aerosol optical depth (AOD) from MODIS Terra, and tropospheric column NO2 from Ozone Monitoring Instrument (OMI) are used to understand the effects of biomass burning on the tropospheric pollution loadings over South Asia during 2003–2013. Biomass burning emission estimates from Global Fire Emission Database...περισσότερα »
Modeling the dynamics of DDT in a remote tropical floodplain: indications of post-ban use?
Abstract Significant knowledge gaps exist regarding the fate and transport of persistent organic pollutants like dichlorodiphenyltrichloroethane (DDT) in tropical environments. In Brazil, indoor residual spraying with DDT to combat malaria and leishmaniasis began in the 1950s and was banned in 1998. Nonetheless, high concentrations of DDT and its metabolites were recently detected in human breast milk in the community of Lake Puruzinho in the Brazilian Amazon. In this work, we couple analysis of soils and sediments from 2005 to 2014 at Puruzinho with a novel dynamic floodplain mode... περισσότερα »
Less indoor cleaning is associated with poor health and unhappiness in adults: Japanese General Social Survey, 2010
Abstract Indoor environment is important to human health and well-being. The aim of the present study was to investigate the relationships among indoor cleaning, rubbish disposal and human health and well-being in a national and population-based setting. Data was retrieved from the Japanese General Social Survey, 2010. Information on demographics, lifestyle factors, frequency of indoor cleaning and rubbish disposal and self-reported health and well-being in Japanese adults was obtained by household interview. Analysis included chi-square test, logistic and multi-nominal regression ... περισσότερα »
CD137 Regulates NFATc1 Expression in Mouse VSMCs through TRAF6/NF-κB p65 Signaling Pathway
Our previous study proved that CD137-CD137L interaction can regulate the expression of NFATc1. Here, we investigated whether CD137 signaling regulates the expression of NFATc1 in mice VSMCs through TRAF6/NF-κB p65 pathway. Data shows that the CD137 expression can be stimulated by TNF-α in a time-dependent manner in mouse VSMCs. Knockdown of TRAF6 by siTRAF6 significantly attenuated agonist-CD137mAb induced increase of NF-κB p65 and NFATc1 in VSMCs. Pretreatment with a NF-κB inhibitor PDTC for 30 min inhibited the expression of p-p65 in both cytoplasm and nucleus in VSMCs. Thus, th... περισσότερα »
Differential Associations between CDH13 Genotypes, Adiponectin Levels, and Circulating Levels of Cellular Adhesive Molecules
CDH13 gene variants with lower adiponectin levels are paradoxically associated with a more favorable metabolic profile. We investigated the statistical association between CDH13 locus variants and adiponectin levels by examining 12 circulating inflammation marker levels and adiposity status in 530 Han Chinese people in Taiwan. After adjustments for clinical covariates, adiponectin levels were positively associated with soluble vascular cell adhesion molecule-1 (sVCAM1) levels and negatively associated with adiposity status and levels of C-reactive protein (CRP), soluble E-selectin... περισσότερα »
Salvage supracricoid laryngectomy after failed radiotherapy and partial laryngectomy.
Related Articles *Salvage supracricoid laryngectomy after failed radiotherapy and partial laryngectomy.* J Laryngol Otol. 2015 Jan;129(1):101-5 Authors: Nakayama M, Miyamoto S, Okabe S, Okamoto M Abstract BACKGROUND: A case of salvage supracricoid laryngectomy with cricohyoidoepiglottopexy after failed radiation therapy and vertical partial laryngectomy had successful oncological and functional outcomes. This is the first reported application of salvage supracricoid laryngectomy with cricohyoidoepiglottopexy after the failure of two major treatments. CASE REPORT: A 65-year-old ma... περισσότερα »
The Effect of Increasing Intracranial Pressure on Ocular Vestibular-Evoked Myogenic Potential Frequency Tuning.
*The Effect of Increasing Intracranial Pressure on Ocular Vestibular-Evoked Myogenic Potential Frequency Tuning.* Ear Hear. 2015 Nov-Dec;36(6):e336-e341 Authors: Jerin C, Wakili R, Kalla R, Gürkov R Abstract OBJECTIVE: Ocular vestibular-evoked myogenic potentials (oVEMPs) represent extraocular muscle activity in response to vestibular stimulation. The authors sought to investigate whether posture-induced increase of the intracranial pressure (ICP) modulated oVEMP frequency tuning, that is, the amplitude ratio between 500-Hz and 1000-Hz stimuli. DESIGN: Ten healthy subjects were e...περισσότερα »
Ocular vestibular-evoked myogenic potentials using air-conducted sound: test parameters and normative data in healthy children; effect of body position on threshold.
*Ocular vestibular-evoked myogenic potentials using air-conducted sound: test parameters and normative data in healthy children; effect of body position on threshold.* Eur Arch Otorhinolaryngol. 2015 Oct 24; Authors: Kastanioudakis I, Saravakos P, Leontis T, Balatsouras DG, Ziavra N Abstract In the present prospective study, we both investigated positioning techniques for the enhancement of oVEMP procedures and the viability of oVEMP testing in a healthy children population. A total of 41 healthy children were enrolled in this study. 21 were boys and 20 were girls, with their ag...περισσότερα »
