Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Σάββατο 15 Απριλίου 2017

Pneumoperitoneum without Intestinal Perforation in a Neonate: Case Report and Literature Review

Pneumoperitoneum in a preterm neonate usually indicates perforation of the intestine and is considered a surgical emergency. However, there are cases of pneumoperitoneum with no evidence of rupture of the intestine reported in the literature. We report a case of pneumoperitoneum with no intestinal perforation in a preterm neonate with respiratory distress syndrome who was on high frequency oscillatory ventilation (HFOV). He developed bilateral pulmonary interstitial emphysema with localized cystic lesion, likely localized pulmonary interstitial emphysema, and recurrent pneumothoraces. He was treated with dexamethasone to wean from the ventilator. Pneumoperitoneum developed in association with left sided pneumothorax following mechanical ventilation and cardiopulmonary resuscitation. Pneumoperitoneum resolved after the pneumothorax was resolved with chest tube drainage. He died from acute cardiorespiratory failure. At autopsy, there was no evidence of intestinal perforation. This case highlights the fact that pneumoperitoneum can develop secondary to pneumothorax and does not always indicate intestinal perforation or require exploratory laparotomy.

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Laryngeal function-preserving operation for T4a laryngeal cancer with vocal cord paralysis — A case report

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Publication date: Available online 14 April 2017
Source:Auris Nasus Larynx
Author(s): Yukinori Asada, Koreyuki Kurosawa, Ko Matsumoto, Takahiro Goto, Kengo Katoh, Takayuki Imai, Shigeru Saijo, Kazuto Matsuura
For locally advanced laryngeal cancers, the standard treatment of choice is chemoradiotherapy if organ function needs to be conserved. Surgical treatment with larynx preservation is conducted only for limited cases. For locally advanced laryngeal cancers such as those with vocal cord fixation and/or cricoid cartilage destruction, there is no apparent standardized organ-preserving surgery keeping the essential laryngeal functions, viz. the airway, deglutition and articulation, uncompromized.Recently, our surgical team saw a patient with T4a advanced laryngeal cancer with vocal cord fixation who aspired to maintain his laryngeal function. Driven by his eagerness, we contrived novel techniques for laryngeal function preservation and performed a two-staged operation.In the first stage, extended vertical partial laryngectomy was conducted including resection of the affected thyroid, arytenoid, and cricoid cartilages, followed by local closure of the hypopharynx. Additionally, laryngeal suspension surgery and cricopharyngeal myotomy were performed in addition to suturing the epiglottis with the intact arytenoid cartilage to enhance swallowing function. In the second stage, airway reconstruction was performed using a local skin flap.As of 10 months after operation, there has been no tumor recurrence, and the reconstructed larynx has been working satisfactorily.In this report we describe an innovative operation that was especially contrived for laryngeal function preservation.



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Bilateral spontaneous symptomatic temporomandibular joint herniation into the external auditory canal: A case report and literature review

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Publication date: Available online 14 April 2017
Source:Auris Nasus Larynx
Author(s): Yong Won Lee, Yong Ho Park
Spontaneous temporomandibular joint (TMJ) herniation is the entity of protrusion of the retrodiscal contents of the TMJ into the external auditory canal (EAC) through a persistent Huschke's foramen. There have been a number of reports of spontaneous TMJ herniation, but there are no reports of bilateral symptomatic TMJ herniation. We report a case of a 70-year-old man who complained of a crunching sound in both ears during mastication. Examination showed bulging from the anterosuperior wall of the EAC on each side when the patient opened his mouth, which pushed the tympanic membrane medially. Bony defects in the corresponding area were seen on computed tomography. We describe a very rare case of bilateral spontaneous TMJ herniation that caused symptoms by having a direct impact on the tympanic membrane.



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Editorial Board

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Publication date: May 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 123, Issue 5





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Society Page

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Publication date: May 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 123, Issue 5





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An update on myofibromas and myofibromatosis affecting the oral regions with report of 24 new cases

Publication date: Available online 5 April 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Molly Housley Smith, John D. Reith, Donald M. Cohen, Nadim M. Islam, Kimberly T. Sibille, Indraneel Bhattacharyya
ObjectivesMyofibromas are uncommon soft tissue tumors exhibiting considerable histopathologic overlap with other benign and malignant entities. The treatment of lesions arising in the oral cavity is controversial. Herein we present 24 new cases and review the literature.Study DesignA search for oral myofibromas was performed within the archives of the UF Oral Pathology and Surgical Pathology Services (1994-2015). Demographic information and immunohistochemical results were recorded. MEDLINE and Web of Science were searched for cases of myofibroma of the oral cavity and oropharynx in the English-language literature between January 1990 and July 2016. The results were analyzed.Results245 total cases were identified: 24 from our present series and 221 from the literature. The distribution by sex was 54.6% male and 45.4% female, and the mean age was 23.1 years. Only 7 patients had known multiple lesions. Treatment modalities varied greatly. Of those with follow-up information, only 9 cases recurred.ConclusionMyofibromas may resemble several other entities. Because of the potential for multiple (perhaps visceral) lesions and possibility for overtreatment, correct diagnosis is of utmost importance. Cases with minimally invasive treatment are sparse, and no standardized treatment protocol is established. This information should be a priority for future publications.



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Information for Readers

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Publication date: May 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 123, Issue 5





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Head and neck surgeons at the vanguard of immunotherapy

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Publication date: May 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 123, Issue 5
Author(s): R. Bryan Bell




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Contents

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Publication date: May 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 123, Issue 5





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Histologic and Immunohistochemical Identification of Cribriform Adenocarcinoma

Publication date: Available online 4 April 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Rashidah Wiley, Aditya Kalgi, Renee Reich, Paul Freedman
ObjectiveTo assess whether tumors originally classified as adenocarcinoma NOS (Adca-NOS), adenoid cystic carcinoma (ACC) and polymorphous low-grade adenocarcinoma (PLGA) could be reclassified as cribriform adenocarcinoma of the tongue and minor salivary gland (CATMSG).Study DesignTumors diagnosed between 1992 and 2014 at Oral Pathology Laboratory, Inc. (NYHQ) were selected. Each tumor was reviewed by 3 oral pathologists to confirm the diagnosis of CATMSG. After review, 11/70 Adca-NOS, 5/38 ACCs, and 5/23 PLGAs met the histological criteria of CATMSG. One case diagnosed as CATMSG in 2014 was used as a control and the following stains were completed: EMA, HBME-1(Hector Battifora Mesothelial-1), p16, and CAM 5.2. 11-Adca, NOS, 2ACCs (tissue was available for only 2 of the 5 adenoid cystic carcinoma cases), and 5-PLGAs underwent immunohistochemical (IHC) staining. Positive HMBE-1, p16 and CAM 5.2 staining along with negative staining for EMA were considered supportive of a diagnosis of CATMSG.ResultsBased on histologic features and IHC results, we were able to reclassify 10 tumors (8 Adca-NOS and 2-PLGA) as CATMSG.ConclusionCATMSG should be from distinguished from other salivary gland tumors with similar histologic features. The diagnosis of CATMSG can be made on H&E alone; but IHC analysis can be useful for confirmation.



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So you want to be published? Pearls for journal publishing

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Publication date: Available online 13 April 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Lauren L. Patton




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Molar incisor malformation in six cases: Description and diagnostic protocol

Publication date: Available online 4 April 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Ingvild Johnsen Brusevold, Thea Martine Granvoll Bie, Christine Sophie Baumgartner, Runa Das, Ivar Espelid
ObjectiveThe term molar incisor malformation (MIM) has recently been presented in scientific literature, where it is described as a condition with localized impaired root development. We here present six recently discovered cases referred to our departments.Study designThe patients were enrolled in the study after referral and examined clinically and radiologically. Two extracted teeth were further examined with micro-CT or microscopy.ResultsAffected teeth were first permanent molars with hypoplastic roots, narrow pulp chambers and a hypercalcified dentine layer cervical to the pulp chamber. Two of the cases also had cervical constrictions on the upper incisors. They were aged 8-12 years, presently healthy, but had experienced serious medical conditions located to the head and neck region in their first year of life. Some of the cases had been referred because of acute infections and pain.ConclusionIn five out of six patients severe health problems early in life located in the head and neck region may be associated with root malformation in molars and incisors. Patients with MIM need to be followed closely and extractions should be planned at the right time to avoid unnecessary infections and pain in addition to orthodontic problems.

Teaser

Molar incisor malformation (MIM) is a newly recognised condition. The dental team should be aware of this condition to make the correct diagnosis and make a control and treatment plan to avoid infection, pain and early tooth loss in affected children.


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Histologic variation in high grade oral epithelial dysplasia when associated with high-risk human papillomavirus

Publication date: May 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 123, Issue 5
Author(s): Sujita Khanal, Patrick J. Trainor, Maryam Zahin, Shin-je Ghim, Joongho Joh, Shesh N. Rai, Alfred Bennett Jenson, Brian S. Shumway
ObjectivesReported cytologic alterations associated with high-risk human papillomavirus (HR-HPV) in oral epithelial dysplasia (HPV-OED) need further characterization.Study DesignArchival cases of high-grade oral epithelial dysplasia (hgOED) (N = 38) were assigned a cytologic score (CS) based on the average number of mitotic, karyorrhectic, and apoptotic cells per high-power field. Three groups were then generated on the basis of increasing CS: Focal (group 1, N = 14), Intermediate (group 2, N = 12), and Diffuse (group 3, N = 12). Polymerase chain reaction–based HPV genotyping and p16 immunohistochemistry were performed.ResultsHR-HPV was found significantly more in group 3 (83.3%) compared with groups 1 and 2 (group 1&2; 42.9% and 41.7%, respectively; P = .047). HPV16 predominated in HR-HPV-positive cases (90.5%). By location, the tongue or the floor of mouth was associated with all groups (P = .04). Increasing CS was associated with a slightly younger age (P = .04) and increased expression of p16 (P = .005). CS and p16 expression were not sensitive but were highly specific predictors for HR-HPV presence. Based on limited follow-up information, HPV-OED does not differ in clinical aggressiveness compared with conventional OED.ConclusionsIncreased CS in hgOED is strongly associated with HR-HPV (mostly HPV16) and p16 expression. CS and p16 expression are specific predictors of HR-HPV presence. Further molecular study and long-term follow-up of HPV-OED are needed.



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The association between condylar bone changes revealed in cone beam computed tomography and clinical dysfunction index in patients with or without temporomandibular joint disorders

Publication date: May 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 123, Issue 5
Author(s): Leila Khojastepour, Mahroo Vojdani, Maryam Forghani
ObjectiveThe aim of the present study was to compare cone beam computed tomography (CBCT) findings pertinent to patients with temporomandibular disorder (TMD) and patients without TMD (non-TMD), as well as to investigate the correlation between these findings and the clinical dysfunction index (Di).Study DesignIn this cross-sectional study, CBCT images of temporomandibular joints (TMJs) were evaluated for condylar bone changes in 84 patients with TMD. The patients were assigned a score using Helkimo's clinical Di, ranging from 1 to 25, and were thereafter subdivided into 3 groups based on the degree of Helkimo's Di. CBCT and clinical records of sex- and age-matched non-TMD patients were used as the control group.ResultsThere was a significant difference in the prevalence of all types of bone changes between TMD and non-TMD groups (all P < .05), except for loose joint bodies. Furthermore, there was a significant correlation between the total amount of bone change and the Helkimo Di score (P < .001).ConclusionEvaluation of CBCT images in the present study revealed significant differences between TMD and non-TMD condyles. There was also a significant relationship between the Helkimo clinical Di and the total amount of condylar bone change in patients with TMD.



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Topographic analysis of the maxillary premolars relative to the maxillary sinus and the alveolar bone using cone beam computed tomography

Publication date: May 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 123, Issue 5
Author(s): Kazuhide Nishihara, Shin-ichiro Yoshimine, Takahiro Goto, Kiyohide Ishihata, Ken-ichi Kume, Takuya Yoshimura, Norifumi Nakamura, Akira Arasaki
ObjectiveThe purpose of the present study was to elucidate the anatomic characteristics of the maxillary premolars for the planning of dental treatment using cone beam computed tomography (CBCT).Study DesignCBCT images were obtained for 150 maxillary premolars in 68 patients. The internal angle formed by the long axis of the maxillary premolars and the long axis of the alveolar bone was evaluated on the cross-sectional images. The vertical relationships between the maxillary premolars and the maxillary sinus were classified into 5 categories. The bone width and internal angle were compared among the images classified into the 5 categories.ResultsThe internal angle was 25.5 ± 6.9° at the maxillary first premolars. The incidence of Type I in the maxillary first premolars was 46.7%. In the maxillary second premolars, the incidence of Type I (14.7%) was significantly lower than the total incidence of Types II, III, IV, and V (85.3%). Type I had the significantly largest internal angle (28.0 ± 7.7°) among all types for the maxillary first premolars.ConclusionWhen considering dental treatment in the maxillary premolars, one should observe the inclination of the maxillary premolars to the alveolar bone as well as the position of the inferior wall of the maxillary sinus.



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Mandibular step osteotomy using CAD/CAM-derived surgical splint: case report

Mandibular step osteotomy is a useful technique for large mandibular setbacks. We report a case of a patient who had a mandibular step osteotomy using a CAD/CAM-derived wafer for mandibular setback with reduction of the arch.

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The anecdote of viral etiopathogenia in ameloblastoma and odontogenic keratocyst: Why don’t we let it go?

Publication date: Available online 14 April 2017
Source:Journal of Oral Biology and Craniofacial Research
Author(s): Bacem A.E.O. Khalele
BackgroundAmeloblastoma (AM) and odontogenic Keratocyst (OKC) are destructive odontogenic lesions of the gnathion. Although their exact pathogeneses are not yet totally understood, the viral etiopathogenesis in AM and KCOT has been proposed. True to syndromic keratocystic odontogenic tumor (sKCOT) and non-syndromic OKC is the high recurrence rate.ObjectivesGiven that shared pathways trailed by AM and by sKCOT/OKC have been suggested, this study, however, contrasts the expression of AM and OKC for viral antibodies.MethodA total of archival 80 paraffin blocks of cases of parakeratinized odontogenic keratocyst (non-syndromic KCOTs) and of ameloblastomas (n=40 for each) were included in this study to be sectioned and stained for two immunohistochemical markers: anti-human papillomavirus and Epstein-Barr virus-encoded latent membrane protein.ResultsAll the submitted cases of AM and parakeratinized OKC were negative for both markers: anti-HPV and anti-LMP-1.ConclusionsAlthough results could have been biased, given the same ethnic group and territory examined in this study, all cases were negative for both markers. Therefore, the viral contribution to the etiopathogenesis in AM and OKC could not be established in this study.



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Role of 1.5mm microplates in treatment of symphyseal fracture of mandible: A stress analysis based comparative study

Publication date: Available online 14 April 2017
Source:Journal of Oral Biology and Craniofacial Research
Author(s): Syed S. Ahmed, Siddharth Bhardwaj, Md. Kalim Ansari, Omar Farooq, Abid Ali Khan
Aims and objectivesTo perform comparative finite element analysis (FEA)for 2.0mm standard miniplate and 1.5mm microplate in isolated symphyseal mandibular fractures.Material and methodTwo FE models of mandible were developed and symphyseal fracture was created in both of them. Each fractured model was reduced and fixed using two mini plates and two microplates, respectively according Champ's principle. Stresses thus developed in the plates after application of masticatory load were observed in the models.ResultsResults of the study indicated there was no significant difference in the stresses developed in either of the bone plating system.Conclusion1.5mm Microplates can be used in place of 2.0mm miniplates in isolated symphyseal fractures of the mandible.



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Subcutaneous dermatofibrosarcoma protuberans, a rare subtype with predilection for the head: A retrospective series of 18 cases

Dermatofibrosarcoma protuberans (DFSP) typically affects the dermis and subcutaneous tissue. The subcutaneous variant is rare.

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Risk factors for free flap failure: a retrospective analysis of 881 free flaps for head and neck defect reconstruction

Publication date: Available online 14 April 2017
Source:International Journal of Oral and Maxillofacial Surgery
Author(s): W. Zhou, W.-B. Zhang, Y. Yu, Y. Wang, C. Mao, C.-B. Guo, G.-Y. Yu, X. Peng
The aim of this study was to identify the risk factors for free flap failure after head and neck reconstructive surgery. The data of 881 consecutive patients who underwent free flap surgery at the Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, between January 2013 and November 2016, were reviewed retrospectively. All surgeries were performed by a single head and neck surgical team. Patient demographic and surgical data that may have an influence on free flap outcomes were recorded. The χ2 test and multivariate logistic regression analysis were used to identify relevant risk factors. In total, 881 free tissue transfer surgeries were included in this study. Free flap failure occurred in 26 of 881 flaps (2.9%). A history of irradiation (odds ratio 0.205, 95% confidence interval 0.07–0.56; P=0.002) was a statistically significant risk factor for free flap failure. Age, diabetes mellitus, history of previous neck surgery to the anastomosis side, donor site, choice of recipient vein, use of a coupler device, and postoperative anticoagulation were not associated with free flap outcomes. Thus, it is concluded that when performing head and neck reconstructive surgery, special attention should be paid to patients who have previously undergone irradiation.



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The keys to conservative treatment of early-stage squamous cell carcinoma of the tonsillar region

Publication date: Available online 14 April 2017
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): O. Laccourreye, P. Castelnau-Marchand, F. Rubin, C. Badoual, P. Halimi, P. Giraud
To analyze the medical literature devoted to work-up, epidemiology, local control, survival, complications and sequelae after conservative treatment for early-stage squamous cell carcinoma of the tonsillar region. An analysis of the PubMed (1975–2016) database was performed using the following keywords and associations: "tonsil/tonsillar region/oropharynx" AND "squamous cell carcinoma" AND "early-stage (I–II; T1–2N0M0)" AND "radiation therapy/radiotherapy" OR "conservative surgery/oropharyngectomy/transoral surgery/radical tonsillectomy". The search retrieved 10 retrospective series documenting local control and/or survival in series with more than 50 cases and a minimum 2 years' follow-up after conservative treatment; no prospective studies, meta-analyses and/or Cochrane analyses were found. Magnetic resonance imaging is the key radiological exam for local extension assessment. Human papilloma virus infection (HPV) is a risk factor that must be screened for systematically, since it induces tumoral radio-sensitivity and increases the risk of specific synchronous and metachronous second primaries. Whatever conservative treatment used, local control and survival rates higher than 85% were achieved. Implementing intensity-modulated radiation therapy reduced the incidence and severity of radiation-related complications and sequelae. Transoral surgery yielded very low morbidity/mortality rates, enabled association to ipsilateral neck dissection, and allowed radiation therapy to be reserved for the management of metachronous second primaries. Transoral surgery appeared to be the first-line option in the majority of cases. Lifetime follow-up adapted to HPV status is mandatory. The development of HPV vaccination does not mean that campaigns against smoking and alcohol abuse are of diminished importance.



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Pediatric sialolithiasis is not related to oral or oropharyngeal infection: A population-based case control study using the Korean National Health Insurance Database

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Publication date: June 2017
Source:International Journal of Pediatric Otorhinolaryngology, Volume 97
Author(s): Seong Jun Won, Eunkyu Lee, Hee Jung Kim, Hyun-kyung Oh, Han-Sin Jeong
ObjectivesPoor oral hygiene is one of the risk factors for sialolithiasis particularly in adults; however the etiology of sialolithiasis in pediatric patients remains largely unknown. The purpose of this study is to identify the association between sialolithiasis and the oral/oropharyngeal infections in the pediatric population, as surrogate indicators for oral hygiene and retrograde infections to the affected salivary gland.MethodsThis was a population based case-control study using the Korean National Health Insurance Database. We identified 10,095 pediatric patients, diagnosed with sialolithiasis, as cases (study period 2011–2015) and 50,475 age/gender/residence matched subjects without sialolithiasis, but with unrelated diseases (e.g., simple trauma in extremities) were set as controls. Logistic regression analyses were conducted to evaluate the association of sialolithiasis with oral or oropharyngeal infections.ResultsThe morbidity rate of sialadenitis was much higher in the cases than the controls (32.92% vs 0.72%, p < 0.0001). By contrast, the prevalence of oral or oropharyngeal infections (stomatitis, gingivitis, periodontitis, and pharyngo-tonsillitis) was significantly lower in pediatric sialolithiasis patients in all age (0–18) groups. The adjusted odds ratios of the multivariate analyses also confirmed significantly less prevalence of the oral and oropharyngeal infections in pediatric sialolithiasis patients.ConclusionOral or oropharyngeal infections were inversely associated with pediatric sialolithiasis, suggesting that pediatric sialolithiasis may result from the intrinsic factors of the salivary gland itself, not from oral or oropharyngeal infections.



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Iatrogenic trichloroacetic acid injury causing necrotizing otitis media and deafness

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Publication date: June 2017
Source:International Journal of Pediatric Otorhinolaryngology, Volume 97
Author(s): Tyler R. Halle, N. Wendell Todd, Jolie Fainberg




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Excision of sublingual gland as treatment for ranulas in pediatric patients

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Publication date: June 2017
Source:International Journal of Pediatric Otorhinolaryngology, Volume 97
Author(s): Brittany N. Nguyen, Barbara N. Malone, James D. Sidman, Brianne Barnett Roby
ObjectiveThe aim of this case study is to demonstrate that post-operative complication rates of sublingual gland excision for treatment of ranulas are equal to or less than alternative methods with a lower recurrence rate than other surgical methods.MethodsThis was a retrospective review of pediatric patients from 2004 to 2015 at Children's Hospitals and Clinics of Minnesota. Sixteen ranulas and 6 plunging ranulas were treated via sublingual gland excision during this time frame. Data examined included age, gender, scans of the lesion, location and size of lesion, surgical procedures, complications, and recurrence.ResultsThere were 22 patients who met criteria. Only one patient had recurrence of the lesion (4.5%). One patient reported lateral tongue numbness post-operatively, and one patient had a hypoglossal nerve injury, with tongue deviation upon exam. Both of these complications were temporary and resolved within months of the procedure.ConclusionAlthough sublingual gland excision is a definitive treatment for ranulas, many surgeons still utilize other methods such as marsupialization, drainage of the cyst, or excision of ranula alone as the primary method of treatment due to concerns about complications. This retrospective study demonstrates that excision of the sublingual gland is both a safe and effective method of treatment for ranulas.



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Clinical manifestations of neuroblastoma with head and neck involvement in children

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Publication date: June 2017
Source:International Journal of Pediatric Otorhinolaryngology, Volume 97
Author(s): Sameer Alvi, Omar Karadaghy, Michelle Manalang, Robert Weatherly
ObjectiveThe purpose of our study is to review our 15-year experience with pediatric patients who have been diagnosed with neuroblastoma, and to determine their most frequent head and neck manifestations and symptoms.Study designRetrospective chart review of electronic medical record.SettingAn academic, tertiary care pediatric hospital.Subjects and MethodsIRB approval from the Office of Research Integrity at Children's Mercy Hospital was obtained. The hospital tumor database was analyzed to identify patients with neuroblastoma, ganglioneuroblastoma, and esthesioneuroblastoma diagnosed between 1997 and 2012. We recorded the various clinical signs and symptoms these patients displayed at their initial presentation, focusing on patients with head and neck involvement. We then determined the relative incidence of these various findings.ResultsOur review yielded 118 patients diagnosed with neuroblastoma, ganglioneuroblastoma, or esthesioneuroblastoma over our 15 year study period. 7 of the 118 patients were diagnosed with primary tumors of the head and neck. Another 19 patients had metastatic head and neck involvement. For those with primary disease, presence of a neck mass and signs of Horner's syndrome were the most common findings. For metastatic disease, craniofacial bony metastasis was the most frequent finding in our study.ConclusionsBased on our data, there are a handful of findings that occur frequently in pediatric head and neck neuroblastoma. Any persistent neck mass, unexplained Horner's syndrome, or periorbital ecchymosis should be carefully evaluated. This study should serve as an aid for the otolaryngologist to be aware of the possible manifestations of this malignancy in children.



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Frosted branch angiitis and cerebral venous sinus thrombosis as an initial onset of neuro-Behçet’s disease: a case report and review of the literature

Frosted branch angiitis is a rare, severe condition. It can be either a primary or a secondary condition and is characterized by rapid deterioration of vision and fulminant retinal vasculitis that manifests as...

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Primary adrenal non-Hodgkin lymphoma: a case report and review of the literature

Lymphomas are cancers that arise from the white blood cells and have been traditionally divided into two large subtypes: Hodgkin and non-Hodgkin lymphoma. B-cell lymphoma is the most common subtype of non-Hodg...

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