Oncology Reports
MicroRNAs are involved in cervical cancer development, progression, clinical outcome and improvement treatment response (Review) Víctor González-Quintana, Lizbeth Palma-Berré, Alma D. Campos-Parra, Eduardo López‑Urrutia, Oscar Peralta-Zaragoza, Rafael Vazquez-Romo, Carlos Pérez-Plasencia View Abstract ------------------------------ Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines Puteri Baharuddin, Nazilah Satar, Kamal Shaik Fakiruddin, Norashikin Zakari...περισσότερα »
OtoRhinoLaryngology & Medicine,New Articles,January 13th,2016
HNC : Elective nodal irradiation Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα Elective nodal irradiation and patterns of failure in head and neck cancer following primary radiotherapy via International Journal of Radiation Oncology*Biology*Physics Publication date: Available online 6 January 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics Author(s): Julie Kjems, Anita B. Gothelf, Katrin Håkansson, Lena Specht, Claus A. Kristensen, Jeppe Friborg PurposeThe delineation of elective clinical target volumes in... περισσότερα »
HNC : Elective nodal irradiation
Elective nodal irradiation and patterns of failure in head and neck cancer following primary radiotherapy via International Journal of Radiation Oncology*Biology*Physics Publication date: Available online 6 January 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics Author(s): Julie Kjems, Anita B. Gothelf, Katrin Håkansson, Lena Specht, Claus A. Kristensen, Jeppe Friborg PurposeThe delineation of elective clinical target volumes in head and neck cancer (HNC) is important, but the extent of lymph node levels necessary to include is debated. A comprehensive analysis...περισσότερα »
Influence of Long-Term Zinc Administration on Spatial Learning and Exploratory Activity in Rats
Influence of Long-Term Zinc Administration on Spatial Learning and Exploratory Activity in Rats: AbstractAnimal brain contains a significant amount of zinc, which is a cofactor for more than 300 enzymes. Moreover, it provides the basis for functioning of more than 2000 transcription factors, and it is necessary for memory formation and learning processes in the brain. The aim of this study was to investigate the effect of zinc supplementation on behavior in 3-month-old rats. For this purpose, the Morris water maze paradigm, hole-board, and T-maze were used. Wistar rats received a s... περισσότερα »
Remote epidural hematoma as a postoperative complication after intracranial tumor resection
Retrospective analysis of 14 cases of remote epidural hematoma as a postoperative complication after intracranial tumor resection: Abstract BackgroundThe occurrence of remote epidural hematoma as a postoperative complication after intracranial tumor resection is rare. This study reviewed experiences treating these hematomas and speculated on the causes of this disease. This study reviewed the treatment experience of 14 such cases. MethodsThe 14 patients included 10 males and 4 females, with an age range of 19 to 65 years old. Six cases of tumors occurred in the sellar region, t...περισσότερα »
Vinorelbine in heavily pretreated recurrent/metastatic head and neck squamous cell carcinoma patients.
Efficacy and safety of vinorelbine in heavily pretreated recurrent/metastatic head and neck squamous cell carcinoma patients.: The aim of this study was to evaluate the efficacy and tolerance of vinorelbine as a single agent in the treatment of recurrent/metastatic head and neck squamous cell carcinoma. Patients were treated with oral or intravenous vinorelbine according to the pluridisciplinary tumor board's decision. Efficacy and safety outcomes were analyzed retrospectively. Twenty-three patients were included in the study. Sixteen patients (69%) had received at least two previou... περισσότερα »
Extranodal diffuse large B-cell lymphoma with monoclonal gammopathy
Extranodal diffuse large B-cell lymphoma with monoclonal gammopathy: an aggressive and primary refractory disease responding to an immunomodulatory agent: Abstract BackgroundAlthough the clinical outcome of patients with diffuse large B cell lymphoma (DLBCL) has been improved by the addition of rituximab to standard chemotherapy, almost one-third fails or relapses after first line treatment. The presence of monoclonal gammopathy (MG) is a known adverse prognostic factor for DLBCL. Because this subset of patients does not benefit from R-CHOP, new therapeutic options are required. H...περισσότερα »
Cognitive effects of donepezil therapy in patients with brain tumors
Cognitive effects of donepezil therapy in patients with brain tumors: a pilot study: AbstractCognitive dysfunction is prevalent among brain tumor patients treated with radiotherapy (RT) and chemotherapy. However, there are no approved pharmacological interventions for cognitive dysfunction in cancer patients. The goal of this pilot study was to examine the efficacy of donepezil, an acetylcholinesterase inhibitor used to treat Alzheimer’s disease, in improving cognitive functions in brain tumor patients previously treated with RT + chemotherapy or chemotherapy alone. Fifteen patien... περισσότερα »
Bilateral central nervous system lesions
The neuroimaging of Leigh syndrome: case series and review of the literature: AbstractLeigh syndrome by definition is (1) a neurodegenerative disease with variable symptoms, (2) caused by mitochondrial dysfunction from a hereditary genetic defect and (3) accompanied by bilateral central nervous system lesions. A genetic etiology is confirmed in approximately 50% of patients, with more than 60 identified mutations in the nuclear and mitochondrial genomes. Here we review the clinical features and imaging studies of Leigh syndrome and describe the neuroimaging findings in a cohort of... περισσότερα »
The immunological impact of premalignant oral lesions, which often precedes development of HNSCC
Treatment to sustain a Th17-type phenotype to prevent skewing toward Treg and to limit premalignant lesion progression to cancer: Abstract While immune suppression is a hallmark of head and neck squamous cell carcinoma (HSNCC), the immunological impact of premalignant oral lesions, which often precedes development of HNSCC, is unknown. The present study assessed the changes in splenic and draining lymph node CD4+ cell populations and their production of select cytokines that occur in mice with carcinogen-induced premalignant oral lesions and the changes that occur as lesions progre... περισσότερα »
Treatment to sustain a Th17-type phenotype to prevent skewing toward Treg and to limit premalignant lesion progression to cancer
Treatment to sustain a Th17-type phenotype to prevent skewing toward Treg and to limit premalignant lesion progression to cancer: Abstract While immune suppression is a hallmark of head and neck squamous cell carcinoma (HSNCC), the immunological impact of premalignant oral lesions, which often precedes development of HNSCC, is unknown. The present study assessed the changes in splenic and draining lymph node CD4+ cell populations and their production of select cytokines that occur in mice with carcinogen-induced premalignant oral lesions and the changes that occur as lesions progre... περισσότερα »
A Model for Predicting Individualś Absolute Risk of Esophageal Adenocarcinoma: Moving towards Tailored Screening and Prevention
A Model for Predicting Individualś Absolute Risk of Esophageal Adenocarcinoma: Moving towards Tailored Screening and Prevention: Abstract Esophageal adenocarcinoma (EAC) is characterized by rapidly increasing incidence and poor prognosis, stressing the need for preventive and early detection strategies. We used data from a nationwide population-based case-control study, which included 189 incident cases of EAC and 820 age- and sex-matched control participants, from 1995 through 1997 in Sweden. We developed risk prediction models based on unconditional logistic regression. Candidate... περισσότερα »
Lysyl oxidase like-4 monoclonal antibody demonstrates therapeutic effect against head and neck squamous cell carcinoma cells and xenografts
Lysyl oxidase like-4 monoclonal antibody demonstrates therapeutic effect against head and neck squamous cell carcinoma cells and xenografts: Abstract A new member of the lysyl oxidase (LOX) family, lysyl oxidase-like 4 (LOXL4), is overexpressed in head and neck squamous cell carcinoma (HNSCC) compared to normal squamous epithelium. A monoclonal antibody (mAb) derived from fusion of Balb/c mouse splenocytes immunized with LOXL4 specific peptide was used to evaluate its therapeutic efficacy in 15 HNSCC cell lines associated with LOXL4 overexpression. For xenograft experiments 41 seve... περισσότερα »
Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread
Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread: AbstractSpread of head and neck cancer along the cranial nerves is often a lethal complication of this tumour. Current treatment options include surgical resection and/or radiotherapy, but recurrence is a frequent event suggesting that our understanding of this tumour and its microenvironment is incomplete. In this study, we have analysed the nature of the perineural tumour microenvironment by immunohistochemistry with particular focus on immune cells and molecules, ...περισσότερα »
Cumulative scores based on plasma D-dimer and serum albumin levels predict survival in esophageal squamous cell carcinoma patients treated with transthoracic esophagectomy
Cumulative scores based on plasma D-dimer and serum albumin levels predict survival in esophageal squamous cell carcinoma patients treated with transthoracic esophagectomy: Abstract BackgroundRecently, studies have shown that plasma D-dimer and serum albumin are prognostic markers for esophageal cancer. The purpose of this study was to evaluate a novel prognostic scoring system—DA score (combination of preoperative plasma D-dimer and serum albumin levels)—and analyze the association between survival of patients with esophageal squamous cell carcinoma (ESCC) and their Glasgow progn... περισσότερα »
Circulating serum levels of angiopoietin-1 and angiopoietin-2 in nasopharynx and larynx carcinoma patients
Circulating serum levels of angiopoietin-1 and angiopoietin-2 in nasopharynx and larynx carcinoma patients: AbstractWe aimed to determine the serum levels of angiogenic factors, namely angiopoietins, in nasopharyngeal and laryngeal carcinoma patients. We also aimed to seek the relation of these molecules with tumor grade and their utility as diagnostic biomarkers. We evaluated angiopoietin 1 and 2 levels innasopharynx and larynx cancer patients before treatment. Angiopoietin 2 levels were significantly elevated in larynx carcinoma patients and tended to be elevated in nasopharynx c...περισσότερα »
Improving the Safety of Oral Chemotherapy
Improving the Safety of Oral Chemotherapy at an Academic Medical Center [Quality in Action]: Purpose: Over the last decade, the use of oral chemotherapy (OC) for the treatment of cancer has dramatically increased. Despite their route of administration, OCs pose many of the same risks as intravenous agents. In this quality improvement project, we sought to examine our current process for the prescription of OC at the Abramson Cancer Center of the University of Pennsylvania and to improve on its safety. Methods: A multidisciplinary team that included oncologists, advanced-practice p... περισσότερα »
ReCAP: Serum Tumor Marker Use in Patients With Advanced Solid Tumors [HEALTH CARE DELIVERY]
ReCAP: Serum Tumor Marker Use in Patients With Advanced Solid Tumors [HEALTH CARE DELIVERY]: [image: F1.small.gif] QUESTION ASKED: The objective of this study is to evaluate the frequency of tumor marker use in patients with advanced solid tumors. SUMMARY ANSWER: Over a 1-year period, the mean number of any individual test per patient was seven tests, and the maximum number was 35 tests; the mean number of total tests per patient was 12 tests, and the maximum number was 70 tests. In a 1-year time frame, 16.3% of patients had more than 12 individual tests, and 34.3% had more t...περισσότερα »
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma: Abstract BackgroundWhile treatment failure in cases of head and neck squamous cell carcinoma (HNSCC) frequently takes the form of locoregional recurrences and distant metastasis, our understanding of the mechanisms of metastasis in HNSCC is limited. We initially performed the upstream and key nodes analysis together with whole gene microarray analysis characterized by distant metastatic potential *in vivo* with HNSCC cell lines and identified JunB, a member of the activator prot... περισσότερα »
Leveraging Optogenetic-Based Neurovascular Circuit Characterization for Repair
Abstract Optogenetic techniques are a powerful tool for determining the role of individual functional components within complex neural circuits. By genetically targeting specific cell types, neural mechanisms can be actively manipulated to gain a better understanding of their origin and function, both in health and disease. The potential of optogenetics is not limited to answering biological questions, as it is also a promising therapeutic approach for neurological diseases. An important prerequisite for this approach is to have an identified target with a uniquely defined role wi... περισσότερα »
Longitudinal Multilevel Modeling of Facial Pain, Muscle Tension, and Stress
The role of masticatory muscle activation on pain in temporomandibular muscle and joint disorders (TMJD) is controversial. This single-group, prospective panel study examined the relationships among masticatory muscle tension, emotional distress, and TMJD pain in a sample of 7,023 observations obtained from 171 individuals using longitudinal multilevel modeling. Three main hypotheses were tested. The first posited that emotional distress and muscle tension directly influenced pain (hypothesis 1a: Distress -> TMJD Pain; hypothesis 1b: Muscle Tension -> TMJD Pain). The second posite... περισσότερα »
Relation between soft tissue and skeletal changes after mandibular setback surgery: A systematic review and meta-analysis
Accurate prediction of hard and soft tissue changes is essential in orthognathic surgery. The aim of the present study was to systematically investigate the relation between soft and hard tissue relocation after mandibular setback surgery. A systematic search was performed, correlation coefficients and ratios were retrieved from the eligible studies, and the risk of bias was assessed. The random effects method was used to combine data. The five eligible studies showed that sagittal changes in pogonion, point B, and incision inferius incisalis are highly correlated with respective ... περισσότερα »
Issue Information - Guidelines for Authors
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1PWccez via IFTTT
Effectiveness of Intralesional Triamcinolone in the Treatment of Keloids in Children
Abstract Background The current treatment of keloids includes surgery, intralesional steroids, and radiotherapy, among others. Radiotherapy is not recommended in children due to its effects on growing tissues. Our aim was to study intralesional triamcinilone therapy of keloids in children and analyze the impact of body location, age of the lesion, and etiology of the keloid on clinical response. Methods We conducted a prospective clinical trial with patients 1 to 14 years of age evaluated for keloid treatment. A soft tissue ultrasound was performed to measure the keloid volume, ... περισσότερα »
Parathyroid Hormone: An Overlooked Variable in Atopic Dermatitis and Vitamin D Research
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1mWSeam via IFTTT
Visual Acuity and Self-Reported Vision Status: Their Associations With Social Isolation in Older Adults
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Objectives: This study examined the associations of two measures of vision impairment (i.e., a clinical measure of visual acuity and self-reported vision status) and social isolation in a nationally representative sample of Americans aged 60 and older. Method: Five cycles of the National Health and Nutrition Examination Survey (NHANES IV; 1999-2008) were used to estimate […]
How would increasing seat belt use affect the number of killed or seriously injured light vehicle occupants?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Publication date: March 2016 Source:Accident Analysis & Prevention, Volume 88 Author(s): Alena Høye The expected effects of increasing seat belt use on the number of killed or seriously injured (KSI) light vehicle occupants have been estimated for three scenarios of increased seat belt use in Norway, taking into account current seat belt use, the effects […]
Evaluation of optimal extracellular vesicle small RNA isolation and qRT-PCR normalisation for serum and urine samples.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
In conclusion, this study identifies optimal methods for isolation of serum and urine EV RNA, and suitable ECs for normalisation of qRT-PCR studies. Such reports should aid in the standardisation of EV microRNA data, particularly for biomarker studies. PMID: 26723490 [PubMed – as supplied by publisher] (Source: Journal of Immunological Methods) from #Medicine-SfakianakisAlexandros via o.lakala70 […]
Array-in-well platform-based multiplex assay for the simultaneous detection of anti-HIV- and treponemal-antibodies, and Hepatitis B surface antigen.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Authors: Talha SM, Saviranta P, Hattara L, Vuorinen T, Hytönen J, Khanna N, Pettersson K Abstract Multiplex assays detecting sets of related clinical analytes simultaneously can save considerable amount of time and resources. Array-in-well (AIW) is a powerful platform for the multiplex detection of different analytes where microarrays can be printed at the bottom of […]
Indirect assessment of neutralizing anti-drug antibodies utilizing pharmacokinetic assay data.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Authors: Vettermann C, Ortiz J, Lee S, Sanchez S, Victor HP, Ma M, Heath T, Gupta S Abstract Neutralizing anti-drug antibodies (NAbs) can adversely impact efficacy and safety of biologic therapeutics. However, current assay formats to detect NAbs are limited in their use during the dosing phase due to interference by circulating drug, resulting in […]
Molecular targeting of papillary thyroid carcinoma with fluorescently labeled ratiometric activatable cell penetrating peptides in a transgenic murine model
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
ConclusionsRACPPs successfully targeted PTC in a transgenic thyroidectomy model, and allowed for residual tumor detection that reduced positive margins beyond what was possible with white‐light surgery alone. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OqfKD6 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios […]
Prognostic significance of tumor regression grade for patients with esophageal squamous cell carcinoma after neoadjuvant chemotherapy followed by surgery
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
ConclusionsTRG is a critical prognostic factor in patients with ESCC who had undergone nCT followed by surgery. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RLdCdI via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Visual Acuity and Self-Reported Vision Status: Their Associations With Social Isolation in Older Adults
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Objectives: This study examined the associations of two measures of vision impairment (i.e., a clinical measure of visual acuity and self-reported vision status) and social isolation in a nationally representative sample of Americans aged 60 and older. Method: Five cycles of the National Health and Nutrition Examination Survey (NHANES IV; 1999-2008) were used to estimate […]
Sentinel lymph node identification using superparamagnetic iron oxide particles versus radioisotope: The French Sentimag feasibility trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
ConclusionsThis new magnetic tracer is a feasible method and a promising alternative to the isotope. It could offer benefits for ambulatory surgery or sites without nuclear medicine departments. J. Surg. Oncol. 2016;9999:XX–XX. © 2016 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OqfKmA via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos […]
How would increasing seat belt use affect the number of killed or seriously injured light vehicle occupants?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Publication date: March 2016 Source:Accident Analysis & Prevention, Volume 88 Author(s): Alena Høye The expected effects of increasing seat belt use on the number of killed or seriously injured (KSI) light vehicle occupants have been estimated for three scenarios of increased seat belt use in Norway, taking into account current seat belt use, the effects […]
Stereotactic body radiation therapy (SBRT) treatment delivery techniques
Influence of different treatment techniques and clinical factors over the intrafraction variation on lung stereotactic body radiotherapy: Abstract PurposeIn the present study we compared three different Stereotactic body radiation therapy (SBRT) treatment delivery techniques in terms of treatment time (TT) and their relation with intrafraction variation (IFV). Besides that, we analyzed if different clinical factors could have an influence on IFV. Finally, we appreciated the soundness of our margins. Materials and methodsForty-five patients undergoing SBRT for stage I lung cance... περισσότερα »
Effects of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic treatment: analysis of molecular alterations by a randomised controlled trial
Effects of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic treatment: analysis of molecular alterations by a randomised controlled trial: *Effects of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic treatment: analysis of molecular alterations by a randomised controlled trial* British Journal of Cancer 114, 21 (12 January 2016). doi:10.1038/bjc.2015.418 Authors: Maki Kawanaka, Jiro Watari, Noriko Kamiya, Takahisa Yamasaki, Takashi Kondo, Fumihiko Toyoshima, Hisatomo Ikehara, Toshi... περισσότερα »
Stereotactic irradiation of spinal lesions
Sub-second and sub-millimeter resolution positional verification for stereotactic irradiation of spinal lesions via International Journal of Radiation Oncology*Biology*Physics Publication date: Available online 12 January 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics Author(s): Colien Hazelaar, Max Dahele, Hassan Mostafavi, Lineke van der Weide, Ben J. Slotman, Wilko F.A.R. Verbakel PurposeSpine stereotactic body radiotherapy (SBRT) requires high positioning accuracy. We report our experience with markerless template matching and triangulation of kilo-voltage...περισσότερα »
Dynamic assessment of carcinoembryonic antigen in the first month after liver resection for colorectal liver metast ases as a rapid‐recurrence predictor
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
ConclusionA CEA half‐life >10 days or rising 1 month after curative‐intent liver resection was associated with rapid recurrence of CRLM within 100 days. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RLdCui via IFTTT
A multi‐institutional analysis of elderly patients undergoing a liver resection for intrahepatic cholangiocarc inoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
ConclusionElderly patients undergoing liver surgery for ICC demonstrated an increased risk of perioperative complications, but comparable long‐term DFS and OS compared with younger patients. Rather, tumor characteristics were more predictive of worse long‐term outcomes. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RLdAm0 via […]
Tumor histopathology predicts outcomes after resection of colorectal cancer liver metastases treated with and without pre‐operative chemotherapy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
ConclusionsHigh proportions of CRCLM fibrosis occur in 20% of patients without radiologic response to chemotherapy. Among untreated patients, high proportion of viable tumor relative to fibrosis is associated with poor RFS after resection. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OqfMLc via IFTTT
S‐1 plus nab‐paclitaxel is a promising regimen for pancreatic cancer in a preclinical model
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
ConclusionsS‐1 and nab‐paclitaxel had a synergetic effect in preclinical studies with good tolerability, and may play a role in stromal depletion and tumor angiogenesis. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RLdBXb via IFTTT
IL‐32α has differential effects on proliferation and apoptosis of human melanoma cell lines
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
ConclusionsThe data presented suggest a direct effect of IL‐32α on the growth of human melanoma and give some insight into the mechanisms which may in part govern this effect. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OqfML8 via IFTTT
Assessing the safety and efficacy of full robotic gastrectomy with intracorporeal robot‐sewn anastomosis for gastric cancer: A randomized clinical trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
ConclusionFull robotic gastrectomy with intracorporeal robot‐sewn anastomosis for gastric cancer is safe and does not increase the complication risk during or after surgery. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RLdBX0 via IFTTT
Expression of the potential cancer stem cell markers CD133 and CD44 in medullary thyroid carcinoma: A ten‐year follow‐up and prognostic analysis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
ConclusionOur study suggested the high expression of CD133 and CD44 in the MTC, and CD133 and CD44 expressions were correlated with capsule invasion and with OS. CD133 and/or CD44 may be prognostic factors for OS and/or DFS in our MTC patients. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc (Source: Journal of Surgical Oncology) from […]
Predictive factors of dysphagia after lateral and superior oropharyngeal reconstruction with free flap transfer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
ConclusionsEarly intervention to minimize the risk of dysphagia should be performed for patients identified with these predictive factors. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RLdA5o via IFTTT
Spontaneous rupture of the long head of the biceps tendon in a woman with hypothyroidism: a case report
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Abstract Background Tendinitis can be a presenting complaint in hypothyroidism, with symptomatic relief being obtained by appropriate management of the primary thyroid deficiency. To the best of our knowledge no other cases of spontaneous rupture of the long head of the biceps tendon during uncontrolled hypothyroidism have yet been reported. Case presentation This case report […]
Removal of dental implant displaced into maxillary sinus by combination of endoscopically assisted and bone repositioning techniques: a case report
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Abstract Background Accidental displacement of a dental implant into the maxillary sinus is an infrequent although not uncommon complication encountered in dental clinical practice, with the main cause thought to be inadequate bone height in the posterior maxilla. We report a case of migration of a dental implant into the maxillary sinus, and discuss the […]
Postoperative Infectious Complications are Associated with Adverse Oncologic Outcomes in Esophageal Cancer Patients Undergoing Preoperative Chemotherapy
Postoperative Infectious Complications are Associated with Adverse Oncologic Outcomes in Esophageal Cancer Patients Undergoing Preoperative Chemotherapy: Abstract BackgroundFor some types of cancer, postoperative complications can negatively influence survival, but the association between these complications and oncological outcomes is unclear for patients with esophageal cancer who receive preoperative treatments. MethodsData were retrospectively analyzed for patients who underwent curative resection following preoperative chemotherapy for esophageal squamous cell carcinoma f...περισσότερα »
Multicenter clinical trial of the Nucleus Hybrid S8 cochlear implant: Final outcomes
Multicenter clinical trial of the Nucleus Hybrid S8 cochlear implant: Final outcomes: Objectives/Hypothesis The concept of expanding electrical speech processing to those with more residual acoustic hearing with a less-invasive shorter cochlear implant (CI) has been ongoing since 1999. A multicenter study of the Nucleus Hybrid S8 CI took place between 2002 and 2011. This report describes the final outcomes of this clinical trial. Study Design Multicenter, longitudinal, single-subject design. Methods Eighty-seven subjects received a Nucleus Hybrid S8 CI in their poorer ear. Speech pe... περισσότερα »
MRI-Guided Cryoablation to Alleviate Pain in Head, Neck and Spine
MRI-Guided Cryoablation to Alleviate Pain in Head, Neck and Spine: *Conditions*: Facet Joints; Degeneration; Neuropathy; Neuralgia *Interventions*: Procedure: Cryoablation under image guidance; Device: MRI Seednet Cryotherapy System *Sponsor*: Brigham and Women's Hospital Groups/CohortsAssigned InterventionsNerve/Facet joint cryoablation Patients with facet joint disease, or compressed or damaged nerve roots causing pain in the head, neck or spine. Procedure: Cryoablation under image guidance Observing efficacy of cryoablation to nerves and facets for the treatment of r...περισσότερα »
Esophagectomy With or Without Prior Ischemic Gastric Preconditioning
Esophagectomy With or Without Prior Ischemic Gastric Preconditioning: *Condition*: Esophageal Cancer *Interventions*: Procedure: Two Stage Esophagectomy; Procedure: One Stage Esophagectomy *Sponsor*: Ki Wan Kim ArmsAssigned InterventionsActive Comparator: Two Stage Esophagectomy Ischemic gastric preconditioning performed 7-10 prior to esophagectomy Procedure: Two Stage Esophagectomy Patients will undergo laparoscopic staging and ischemic gastric conditioning and pyloric Botox injection 7-10 days prior to an esophagectomy with gastric pull-up reconstruction Active Comparator... περισσότερα »
A European multi-language initiative to make the general population aware of independent clinical research: the European Communication on Research Awareness Need project
A European multi-language initiative to make the general population aware of independent clinical research: the European Communication on Research Awareness Need project: Background: The ECRAN (European Communication on Research Awareness Needs) project was initiated in 2012, with support from the European Commission, to improve public knowledge about the importance of independent, multinational, clinical trials in Europe. Methods: Participants in the ECRAN consortium included clinicians and methodologists directly involved in clinical trials; researchers working in partnership with ... περισσότερα »
The Clinical Physics Research of Image Guided Adaptive Radiation Therapy for Esophagus Cancer
The Clinical Physics Research of Image Guided Adaptive Radiation Therapy for Esophagus Cancer: *Condition*: Esophageal Cancer *Intervention*: Radiation: Dose adaptation *Sponsor*: Sun Yat-sen University ArmsAssigned InterventionsExperimental: adaptive radiation therapy (ART) 40 patients treated with ART, using dose adaptation method to match the change of PTV and movement of OARs and achieve an optimal dose distribution using online CBCT images. Radiation: Dose adaptation Replanning the treatment to adapt the change of PTV and movement of OARs to achieve an optimal dose distr... περισσότερα »
Bisphosphonates related osteonecrosis of the jaw
Histopathological features of bisphosphonates related osteonecrosis of the jaw in rats with and without vitamin d supplementation via Oral Biology Publication date: Available online 11 January 2016 *Source:*Archives of Oral Biology Author(s): Saim Yanik, Mutan Hamdi, Suna Erkılıç, Zehra Bozdağ, Tuncer Demir, Sedat Çetiner ObjectiveAim of this study was to investigate the effect of vitamin-D3 on the osteonecrosis of bone that was induced after tooth extraction was conducted on rats that were given zoledronic acid (Z.A).Material and methodsAnimals were divided into four groups. Two of th... περισσότερα »
Septic Lateral Sinus Thrombosis: Sinus Exploration Is Unnecessary
Septic Lateral Sinus Thrombosis: Sinus Exploration Is Unnecessary: The algorithm of treatment of septic lateral sinus thrombosis (SLST) has undergone a paradigm shift with the understanding of the natural history of sigmoid sinus thrombosis. Thus, the recent medical literature promulgates the management of these cases with no sinus exploration. However, in view of marked paucity of literature on the cited subject, not much is known about this form of treatment. We present our experience of treating two paediatric cases of SLST with mastoid surgery and no sinus exploration: both case...περισσότερα »
Correlation between preoperative predictions and surgical findings in the parotid surgery for tumors
Correlation between preoperative predictions and surgical findings in the parotid surgery for tumors: Abstract BackgroundTo compare preoperative CT/MRI based predictions with real surgical findings for deep lobe parotid gland surgery. MethodsThe study analyzed 122 parotidectomies (2004–2014) for benign tumor removal. The facial nerve, the Utrecht line, the Conn’s arc, and the retromandibular vein were used as landmarks for CT/MRI presurgical evaluation of patients. We assessed 106 CT images and 86 MRI images. The study compared preoperative evaluation of tumor location with its... περισσότερα »
Effect of Cigarette Smoking and Passive Smoking on Hearing Impairment: Data from a Population–Based Study
Effect of Cigarette Smoking and Passive Smoking on Hearing Impairment: Data from a Population–Based Study: by Jiwon Chang, Namhyung Ryou, Hyung Jin Jun, Soon Young Hwang, Jae-Jun Song, Sung Won Chae Objectives In the present study, we aimed to determine the effect of both active and passive smoking on the prevalence of the hearing impairment and the hearing thresholds in different age groups through the analysis of data collected from the Korea National Health and Nutrition Examination Survey (KNHANES). Study Design Cross-sectional epidemiological study. Methods The KNHANES ... περισσότερα »
Development of Tablet Formulation of Amorphous Solid Dispersions Prepared by Hot Melt Extrusion Using Quality by Design Approach
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
ABSTRACT The objective of the study was to identify the extragranular component requirements (level and type of excipients) to develop an immediate release tablet of solid dispersions prepared by hot melt extrusion (HME) process using commonly used HME polymers. Solid dispersions of compound X were prepared using polyvinyl pyrrolidone co-vinyl acetate 64 (PVP VA64), Soluplus, […]
Using PG-Liposome-Based System to Enhance Puerarin Liver-Targeted Therapy for Alcohol-Induced Liver Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
Abstract A critical issue for alcohol-induced liver disease (ALD) therapeutics is the lack of a highly efficient delivery system. In this study, a Puerarin-propylene glycol-liposome system was prepared for the purpose of targeting puerarin, an isoflavon, to the liver. Transmission electron microscope (TEM) results showed the liposomes to be spherical in shape with an average […]
Predictors of disease complications and treatment outcome among patients with chronic suppurative otitis media attending a tertiary hospital, Mwanza Tanzania
Predictors of disease complications and treatment outcome among patients with chronic suppurative otitis media attending a tertiary hospital, Mwanza Tanzania: Chronic suppurative otitis media (CSOM) is a major health problem in developing countries causing hearing loss and life threatening complications. Early and effective treatment based on the knowledge of causat... Abstract Background Chronic suppurative otitis media (CSOM) is a major health problem in developing countries causing hearing loss and life threatening complications. Early and effective treatment based on the know... περισσότερα »
Acoustic rhinometry and video endoscopic scoring to evaluate postoperative outcomes in endonasal spreader graft surgery with septoplasty and turbinoplasty for nasal valve collapse
Acoustic rhinometry and video endoscopic scoring to evaluate postoperative outcomes in endonasal spreader graft surgery with septoplasty and turbinoplasty for nasal valve collapse: Abstract BackgroundNasal obstruction is a common complaint seen by otolaryngologists. The internal nasal valve (INV) is typically the narrowest portion of the nasal cavity, and if this area collapses on inspiration the patient experiences significant symptoms of nasal obstruction. The nasal obstruction is further compounded if the INV is narrower than normal. Previous studies have evaluated the effectiv... περισσότερα »
Epistaxis in hereditary hemorrhagic telangiectasia
Epistaxis in hereditary hemorrhagic telangiectasia: an evidence based review of surgical management: AbstractPatients with Hereditary Hemorrhagic Telangiectasia (HHT) frequently present with epistaxis. Up to 98 % of these patients will have epistaxis at some point in their life. There are multiple ways to deal with this problem, including conservative, medical and surgical options. We present a case and an update on the treatment options for HHT, with a focus on the newer and experimental techniques.
Band limited chirp stimulation in vestibular evoked myogenic potentials
Band limited chirp stimulation in vestibular evoked myogenic potentials: AbstractAir conducted vestibular evoked myogenic potentials (VEMP) can be elicited by various low frequency and intense sound stimuli, mainly clicks or short tone bursts (STB). Chirp stimuli are increasingly used in diagnostic audiological evaluations as an effective means to obtain acoustically evoked responses in narrowed or extended frequency ranges. We hypothesized in this study that band limited chirp stimulation, which covers the main sensitivity range of sound sensitive otolithic afferents (around 500 H... περισσότερα »
Pathologic features of metastatic lymph nodes identified from prophylactic central neck dissection in patients with papillary thyroid carcinoma
Pathologic features of metastatic lymph nodes identified from prophylactic central neck dissection in patients with papillary thyroid carcinoma: AbstractThe importance of pathologic features of metastatic lymph nodes (LNs), such as size, number, and extranodal extension, has been recently emphasized in patients with papillary thyroid carcinoma (PTC). We evaluated the characteristics of metastatic LNs identified after prophylactic central neck dissection (CND) in patients with PTC. We performed a retrospective review of 1,046 patients who underwent unilateral or bilateral thyroidect... περισσότερα »
Chirurgie der Nase und Nasennebenhöhlen
Chirurgie der Nase und Nasennebenhöhlen: Laryngo-Rhino-Otol 2016; 95: 51-67 DOI: 10.1055/s-0041-107799 Übersichtlich werden in komprimierter Form die prinzipiellen Operationstechniken der Nase (funktionell) und Nasennebenhöhlen (entzündliche Erkrankungen) abgebildet. Herausgestellt wird die Rolle des Septums für die Funktion, Form sowie die Stabilität der Nase als zentrale Struktur (insbesondere für die Nasenspitze und den Nasenrücken), sowie für den Erfolg einer Rhinoplastik. Zusätzlich wird auf den Regulationseffekt der unteren Nasenmuscheln bei nasaler Obstruktion durch Reduktio... περισσότερα »
Rhabdomyomatous Mesenchymal Hamartoma: A Deep Subcutaneous Lesion in the Sternoclavicular Area
Rhabdomyomatous Mesenchymal Hamartoma: A Deep Subcutaneous Lesion in the Sternoclavicular Area: Abstract Cutaneous rhabdomyomatous mesenchymal hamartoma (RMH) is a rare benign tumor composed of two or more types of mesenchymal-derived cells. RMHs are generally sporadic and independent, but they can be associated with congenital abnormalities. We report a subcutaneous case of RMH in the sternoclavicular area with two recurrences after complete surgical excision. The course is variable and can range from spontaneous resolution to repeated recurrences.
Optimale Schmerztherapie nach Tonsillektomie: ein ungelöstes Problem
*Optimale Schmerztherapie nach Tonsillektomie: ein ungelöstes Problem: * *Laryngo-Rhino-Otol 2016; 95: 15-23DOI: 10.1055/s-0041-107985* *Die Tonsillektomie gehört zu den schmerzhaftesten operativen Eingriffen überhaupt. Leider bekommen Patienten immer noch Aussagen zu hören wie: „Da müssen Sie durch“ oder „Sie bekommen doch schon genug Schmerzmedikamente“. Fragt man die behandelten Anästhesisten und HNO-Ärzte, so kann man zu hören bekommen: „Schmerzen nach Tonsillektomie seien kein Problem, man habe ein bewährtes Schmerzregime“. Im Widerspruch dazu zeigen klinische Untersuchungen,... περισσότερα »
Laryngo-Rhino-Otologie
Morbus Menière – Kausaler Faktor: chronisch zerebrospinale venöse Insuffizienz? Beidseitige chronische Mittelohrerkrankungen – Operation beider Ohren am selben Tag günstiger als zweizeitiges Vorgehen Klinische Untersuchung in der HNO-Heilkunde, Kopf- und Halschirurgie – Teil I: Ohr und Nase Tipps & Tricks – Epistaxis Management unter Berücksichtigung der Kontamination Optimale Schmerztherapie nach Tonsillektomie: ein ungelöstes Problem Die Tonsillektomie gehört zu den schmerzhaftesten operativen Eingriffen überhaupt. Leider bekommen Patienten immer noch Aussagen zu hören wie: „Da ... περισσότερα »
Childhood Pemphigus Foliaceus with Exclusive Immunoglobulin G Autoantibodies to Desmocollins
Abstract Pemphigus refers to a group of potentially fatal blistering skin diseases that are often due to the deleterious effects of autoantibodies directed against desmosomal antigens. Although desmogleins have been mainly implicated as autoantigens in pemphigus, a steadily growing body of evidence suggests that other desmosomal proteins may be causally involved as well. Antibodies directed against desmocollin-3 have been shown to play a direct role in the pathogenesis of several types of pemphigus. Here we describe the case of a child with localized pemphigus foliaceus and immuno...περισσότερα »
Pediatric Dermatology Photoquiz: An Ulcerated Nodule on the Abdomen of a Child
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Pediatric Dermatology Photoquiz: A 9-Year Old Girl with Papules on Her Hands
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Patient Perspectives: Atopic dermatitis (eczema)
With the now-universal access to web-based information, there is a need to provide clear, concise, and accurate medical information to patients and their families informing them about their medical conditions. Most practioners rely on electronic health records, and the ability to share information with patients in the form of "patients handouts" is easier than ever. Pediatric dermatologists, dermatologists, pediatricians, family practitioners, and internists diagnose a number of conditions in common and the SPD has initiated work on a patient handout database (found at http://ped... περισσότερα »
Cutaneous adverse events (AEs) of anti-programmed cell death (PD)-1 therapy in patients with metastatic melanoma: A single-institution cohort
Anti-programmed cell death (PD)-1 therapy is emerging as the backbone of new standard of care immunotherapy for metastatic melanoma. Immune-related cutaneous events are observed in these patients. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1mWPA4u via IFTTT
Offizinale Grundlagen und ihre Charakteristik
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Onychocola canadensis Sigler bei Onychomykose
Zusammenfassung Schimmelpilze werden als Erreger einer Onychomykose immer häufiger isoliert. Ursache sind beispielsweise *Scopulariopsis brevicaulis, Fusarium, Aspergillus, Acremonium, Neoscytalidium dimidiatum, Arthrographis kalrae* und *Chaetomium*. Hier wird erstmals in Deutschland über 5 Patienten mit Verdacht auf eine Onychomykose durch *Onychocola canadensis* berichtet. Systemische Antimykotika gelten als nicht wirksam bei Non-Dermatophyte-Mould (NDM)-Onychomykosen. Im Einzelfall scheint Terbinafin durchaus wirksam bei einer *Onychocola-canadensis*-Infektion des Nagels zu se... περισσότερα »
In Response to: Comparison of Methods for the Repair of Acute Tympanic Membrane Perforations: Silk Patch vs. Paper Patch
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28th Annual Meeting of the Wound Healing Society SAWC-Spring/WHS Joint Meeting
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Clinical Otolaryngology
Acknowledgements to reviewers Pragmatic detection of anxiety and depression in a prospective cohort of voice outpatient clinic attenders Chronic rhinosinusitis: patient experiences of primary and secondary care – a qualitative study The outcome of septorhinoplasty surgery on olfactory function Sino‐Nasal Outcome Test‐22: translation, cultural adaptation and validation in Portugal Quality‐of‐life and functional outcomes following pharyngolaryngectomy: a systematic review of literature Temperature rises in the round window caused by various light sources during insertion of rigid e... περισσότερα »
Evaluation of optimal extracellular vesicle small RNA isolation and qRT-PCR normalisation for serum and urine samples.
In conclusion, this study identifies optimal methods for isolation of serum and urine EV RNA, and suitable ECs for normalisation of qRT-PCR studies. Such reports should aid in the standardisation of EV microRNA data, particularly for biomarker studies. PMID: 26723490 [PubMed – as supplied by publisher] (Source: Journal of Immunological Methods) from #Medicine-Sfakianakis via simeraentaxei… Continue reading Evaluation of optimal extracellular vesicle small RNA isolation and qRT-PCR normalisation for serum and urine samples.
Array-in-well platform-based multiplex assay for the simultaneous detection of anti-HIV- and treponemal-antibodies, and Hepatitis B surface antigen.
Authors: Talha SM, Saviranta P, Hattara L, Vuorinen T, Hytönen J, Khanna N, Pettersson K Abstract Multiplex assays detecting sets of related clinical analytes simultaneously can save considerable amount of time and resources. Array-in-well (AIW) is a powerful platform for the multiplex detection of different analytes where microarrays can be printed at the bottom of… Continue reading Array-in-well platform-based multiplex assay for the simultaneous detection of anti-HIV- and treponemal-antibodies, and Hepatitis B surface antigen.
Indirect assessment of neutralizing anti-drug antibodies utilizing pharmacokinetic assay data.
Authors: Vettermann C, Ortiz J, Lee S, Sanchez S, Victor HP, Ma M, Heath T, Gupta S Abstract Neutralizing anti-drug antibodies (NAbs) can adversely impact efficacy and safety of biologic therapeutics. However, current assay formats to detect NAbs are limited in their use during the dosing phase due to interference by circulating drug, resulting in… Continue reading Indirect assessment of neutralizing anti-drug antibodies utilizing pharmacokinetic assay data.
In vivo depletion and genetic targeting of mouse intestinal CX3CR1(+) mononuclear phagocytes.
Authors: Koscsó B, Gowda K, Bogunovic M Abstract Mononuclear phagocytes (MPs) are an essential component of the intestinal immune system. They are comprised of a few dendritic cell and macrophage subsets, all with the common ability to sample extracellular milieu and to discriminate between dangerous and innocuous signals. Despite the commonality, each MP subset acquires… Continue reading In vivo depletion and genetic targeting of mouse intestinal CX3CR1(+) mononuclear phagocytes.
Breast cancer survival in the US and Europe: a CONCORD high-resolution study
International journal of cancer. Journal international du cancer from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1l51fwa via IFTTT
“Threshold Findings” in an Ecological Study
Epidemiology (Cambridge, Mass.) from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1mWRvpA via IFTTT
The efficacy and safety of airway foreign body removal by balloon catheter via flexible bronchoscope in children-A retrospective analysis
The efficacy and safety of airway foreign body removal by balloon catheter via flexible bronchoscope in children-A retrospective analysis: To investigate the efficacy and safety of the airway foreign body removal by balloon catheter via flexible bronchoscope in children AbstractObjectives To investigate the efficacy and safety of the airway foreign body removal by balloon catheter via flexible bronchoscope in children Methods Retrospective analysis was performed of 26 cases of airway foreign body removal in children by balloon catheter via flexible bronchoscope in the First Affili... περισσότερα »
Safety of Paediatric Day-Stay Laryngeal Surgery for Recurrent Respiratory Papillomatosis
Safety of Paediatric Day-Stay Laryngeal Surgery for Recurrent Respiratory Papillomatosis: Safety assessment of day-stay laryngeal surgery in a cohort of children with Recurrent Respiratory Papillomatosis (RRP). Recurrent Respiratory Papillomatosis is a chronic debilitating disease which usually requires multiple recurrent interventions under general anaesthesia. Day-stay surgery is an attractive option as it allows avoiding the inconvenience and costs of routine overnight admissions while recovering in the safe environment of the family home. This is the first study to assess the sa...περισσότερα »
Ischemia-modified albumin, brain natriuretic peptide, and growth differentiation factor-15 levels in patients with nasal polyps
Ischemia-modified albumin, brain natriuretic peptide, and growth differentiation factor-15 levels in patients with nasal polyps: Nasal polyps (NP) are a chronic inflammatory disease of the nasal mucosa; their etiology is suspected to involve oxidative stress. Growth differentiation factor-15 (GDF-15), brain natriuretic peptide (BNP), and ischemia-modified albumin (IMA) are biomarkers used especially in the early diagnosis and follow-up of cardiovascular diseases. The aim of this study was to assess levels of serum GDF-15, BNP, and IMA in patients with NP and to compare them with tho... περισσότερα »
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer: Thyroid Jan 2016, Vol. 26, No. 1: 1-133. Author information Bryan R. Haugen,1,* Erik K. Alexander,2 Keith C. Bible,3 Gerard M. Doherty,4 Susan J. Mandel,5 Yuri E. Nikiforov,6 Furio Pacini,7 Gregory W. Randolph,8 Anna M. Sawka,9 Martin Schlumberger,10 Kathryn G. Schuff,11 Steven I. Sherman,12 Julie Ann Sosa,13 David L. Steward,14 R. Michael Tuttl... περισσότερα »
Melanoma of the Oral Cavity
Melanoma of the Oral Cavity: an Analysis of 46 New Cases with Emphasis on Clinical and Histopathologic Characteristics: AbstractMelanoma of the oral cavity is a rare malignancy that carries a poor prognosis. We identified 46 new cases of both primary and metastatic melanoma to the oral cavity. Following IRB approval, these cases were obtained from the Oral Pathology Biopsy Service archives of the UF College of Dentistry (1994–2014), the UK College of Dentistry (1997–2015), and the UM Medical Center (1988–2015). All slides were reviewed. The location, age, race, gender, clinical imp...περισσότερα »
The diagnostic utility of fluorescence in situ hybridization (FISH) for detecting FGFR1 translocations
Phosphaturic Mesenchymal Tumor Involving the Head and Neck: A Report of Five Cases with FGFR1 Fluorescence In Situ Hybridization Analysis: AbstractPhosphaturic mesenchymal tumor (PMT) is a rare neoplasm; however, it is the most common cause of tumor-induced osteomalacia (TIO), a paraneoplastic syndrome characterized by renal phosphate wasting and hypophosphatemia. A subset of PMTs harbours an *FGFR1* translocation although this alteration has not been demonstrated in PMT involving a head and neck site. We present a series of five PMTs involving the head and neck and demonstrate the... περισσότερα »
Phosphaturic Mesenchymal Tumor Involving the Head and Neck: A Report of Five Cases with FGFR1 Fluorescence In Situ Hybridization Analysis
Phosphaturic Mesenchymal Tumor Involving the Head and Neck: A Report of Five Cases with FGFR1 Fluorescence In Situ Hybridization Analysis: AbstractPhosphaturic mesenchymal tumor (PMT) is a rare neoplasm; however, it is the most common cause of tumor-induced osteomalacia (TIO), a paraneoplastic syndrome characterized by renal phosphate wasting and hypophosphatemia. A subset of PMTs harbours an *FGFR1* translocation although this alteration has not been demonstrated in PMT involving a head and neck site. We present a series of five PMTs involving the head and neck and demonstrate the... περισσότερα »
Variability of Ratings in the Otolaryngology Standardized Letter of Recommendation
Variability of Ratings in the Otolaryngology Standardized Letter of Recommendation: Objective To determine the variability of ratings given to students on the otolaryngology standardized letter of recommendation (SLOR). Study Design Retrospective review. Setting Academic otolaryngology training program. Subjects and Methods 496 SLORs to the Cleveland Clinic Otolaryngology Training Program were reviewed. The SLORs were extracted from the applications and analyzed. The distributions of ratings across the 10 categories were statistically analyzed including distribution and standard...περισσότερα »
Predicting Surgical Response Using Tensiometry in OSA Patients after Genioglossus Advancement with Uvulopalatopharyngoplasty
Predicting Surgical Response Using Tensiometry in OSA Patients after Genioglossus Advancement with Uvulopalatopharyngoplasty: Objective To evaluate the role of tension on the genioglossus muscle in the performance of genioglossus advancement on sleep-disordered breathing in patients undergoing multilevel obstructive sleep apnea (OSA) surgery. Study Design Prospective study. Setting Academic practice. Subjects and Methods Twenty-three subjects underwent genioglossus advancement with uvulopalatopharyngoplasty for OSA. Subjects underwent pre- and postoperative polysomnography, ceph... περισσότερα »
Bacterial Biofilm in Salivary Gland Stones: Cause or Consequence?
Bacterial Biofilm in Salivary Gland Stones: Cause or Consequence?: Objective The pathogenesis of salivary calculi is not yet clear; however, 2 theories have been formulated: (1) "the classic theory," based on calcium microdeposits in serous and ductal acinous cells, successively discharged into the ducts; (2) "the retrograde theory," based on a retrograde migration of food, bacteria, and so on from the oral cavity to the salivary duct. The aim of the present study is to highlight the role of bacteria and biofilm in stone formation. Study Design Case series without comparison. Sett... περισσότερα »
Common bile duct diameter in an asymptomatic population: A magnetic resonance imaging study.
Related Articles *Common bile duct diameter in an asymptomatic population: A magnetic resonance imaging study.* World J Radiol. 2015 Dec 28;7(12):501-508 Authors: Peng R, Zhang L, Zhang XM, Chen TW, Yang L, Huang XH, Zhang ZM Abstract AIM: To measure the common bile duct (CBD) diameter by magnetic resonance cholangiopancreatography (MRCP) in a large asymptomatic population and analyze its some affecting factors. METHODS: This study included 862 asymptomatic subjects who underwent MRCP. The CBD diameter was measured at its widest visible portion on regular end-expiration MRCP for ... περισσότερα »
Recovery of serum testosterone following neoadjuvant and adjuvant androgen deprivation therapy in men treated with prostate brachytherapy.
Related Articles *Recovery of serum testosterone following neoadjuvant and adjuvant androgen deprivation therapy in men treated with prostate brachytherapy.* World J Radiol. 2015 Dec 28;7(12):494-500 Authors: Tsumura H, Satoh T, Ishiyama H, Hirano S, Tabata KI, Kurosaka S, Matsumoto K, Fujita T, Kitano M, Baba S, Hayakawa K, Iwamura M Abstract AIM: To investigate the time course of testosterone (T) recovery after cessation of androgen deprivation therapy (ADT) in patients treated with brachytherapy. METHODS: One-hundred and seventy-four patients treated between June 1999 and Febr...περισσότερα »
Three-dimensional imaging of the uterus: The value of the coronal plane.
Related Articles *Three-dimensional imaging of the uterus: The value of the coronal plane.* World J Radiol. 2015 Dec 28;7(12):484-493 Authors: Wong L, White N, Ramkrishna J, Júnior EA, Meagher S, Costa FD Abstract Advent in three-dimensional (3D) imaging technology has seen 3D ultrasound establish itself as a useful adjunct complementary to traditional two-dimensional imaging of the female pelvis. This advantage largely arises from its ability to reconstruct the coronal plane of the uterus, which allows further delineation of many gynecological disorders. 3D imaging of the uterus...περισσότερα »
Amyloid positron emission tomography and cognitive reserve.
Related Articles *Amyloid positron emission tomography and cognitive reserve.* World J Radiol. 2015 Dec 28;7(12):475-483 Authors: Bauckneht M, Picco A, Nobili F, Morbelli S Abstract Alzheimer's disease (AD) is characterized by a non-linear progressive course and several aspects influence the relationship between cerebral amount of AD pathology and the clinical expression of the disease. Brain cognitive reserve (CR) refers to the hypothesized capacity of an adult brain to cope with brain damage in order to minimize symptomatology. CR phenomenon contributed to explain the disjuncti... περισσότερα »
Multi-detector computed tomography imaging of large airway pathology: A pictorial review.
Related Articles *Multi-detector computed tomography imaging of large airway pathology: A pictorial review.* World J Radiol. 2015 Dec 28;7(12):459-474 Authors: Jugpal TS, Garg A, Sethi GR, Daga MK, Kumar J Abstract The tracheobronchial tree is a musculo-cartilagenous framework which acts as a conduit to aerate the lungs and consequently the entire body. A large spectrum of pathological conditions can involve the trachea and bronchial airways. These may be congenital anomalies, infections, post-intubation airway injuries, foreign body aspiration or neoplasms involving the airway. ... περισσότερα »
Predicting gestational diabetes mellitus during the first trimester using anthropometric measurements and HOMA-IR
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Abstract Purpose To determine the predictability of gestational diabetes mellitus (GDM) during the first trimester using the degree of insulin resistance and anthropometric measurements and to assign the risk of developing GDM by weight gained during pregnancy (WGDP). Methods A total of 250 singleton pregnancies at 7–12 gestational weeks were studied. Body mass index (BMI), […]
Podcasting in the STEM disciplines: The implications of supplementary lecture recording and ‘lecture flipping.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Lecture capture, or ‘podcasting’ technology offers a new and engaging format of learning materials that can be used to increase the flexibility and interactivity of learning and teaching environments. Here we discuss different ways that these recordings can be incorporated into STEM discipline teaching, and the impact this can have on students’ learning. from #Infections […]
Comparing the temporal colonization and microbial diversity of showerhead biofilms in Hawai’i and Colorado
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
The household is a potential source of opportunistic pathogens to humans, a particularly critical issue for immunodeficient individuals. An important human-microbe interface is the biofilm that develops on showerhead surfaces. Once microbe-laden biofilms become aerosolized, they can potentially be inhaled into the lungs. Understanding how quickly a new showerhead becomes colonized would provide useful information […]
Simultaneous saccharification and fermentation of dilute alkaline-pretreated corn stover for enhanced butanol production by Clostridium saccharobutylicum DSM 13864
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Simultaneous saccharification and fermentation (SSF) process was applied for biobutanol production by Clostridium saccharobutylicum DSM 13864 from corn stover (CS). The key influential factors in SSF process, including corn steep liquor concentration, dry biomass and enzyme loading, SSF temperature, inoculation size and pre-hydrolysis time were optimized. In 5-L bioreactor with SSF process, butanol titer and […]
Fungal denitrification: Bipolaris sorokiniana exclusively denitrifies inorganic nitrogen in the presence and absence of oxygen
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Fungi may play an important role in the production of the greenhouse gas nitrous oxide (N2O). Bipolaris sorokiniana is a ubiquitous saprobe found in soils worldwide, yet denitrification by this fungal strain has not previously been reported. We aimed to test if B. sorokiniana would produce N2O and CO2 in the presence of organic and […]
Podcasting in the STEM disciplines: The implications of supplementary lecture recording and ‘lecture flipping.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Lecture capture, or ‘podcasting’ technology offers a new and engaging format of learning materials that can be used to increase the flexibility and interactivity of learning and teaching environments. Here we discuss different ways that these recordings can be incorporated into STEM discipline teaching, and the impact this can have on students’ learning. from Infection […]
Comparing the temporal colonization and microbial diversity of showerhead biofilms in Hawai’i and Colorado
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
The household is a potential source of opportunistic pathogens to humans, a particularly critical issue for immunodeficient individuals. An important human-microbe interface is the biofilm that develops on showerhead surfaces. Once microbe-laden biofilms become aerosolized, they can potentially be inhaled into the lungs. Understanding how quickly a new showerhead becomes colonized would provide useful information […]
Cutaneous adverse events (AEs) of anti-programmed cell death (PD)-1 therapy in patients with metastatic melanoma: A single-institution cohort
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Anti-programmed cell death (PD)-1 therapy is emerging as the backbone of new standard of care immunotherapy for metastatic melanoma. Immune-related cutaneous events are observed in these patients. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1mWPA4u via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OhrLwW via IFTTT
Offizinale Grundlagen und ihre Charakteristik
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1RBfrvp via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OhrKce via IFTTT
Simultaneous saccharification and fermentation of dilute alkaline-pretreated corn stover for enhanced butanol production by Clostridium saccharobutylicum DSM 13864
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
Simultaneous saccharification and fermentation (SSF) process was applied for biobutanol production by Clostridium saccharobutylicum DSM 13864 from corn stover (CS). The key influential factors in SSF process, including corn steep liquor concentration, dry biomass and enzyme loading, SSF temperature, inoculation size and pre-hydrolysis time were optimized. In 5-L bioreactor with SSF process, butanol titer and […]
Predicting gestational diabetes mellitus during the first trimester using anthropometric measurements and HOMA-IR
Abstract Purpose To determine the predictability of gestational diabetes mellitus (GDM) during the first trimester using the degree of insulin resistance and anthropometric measurements and to assign the risk of developing GDM by weight gained during pregnancy (WGDP). Methods A total of 250 singleton pregnancies at 7–12 gestational weeks were studied. Body mass index (BMI), waist/hip ratio (WHR), quantitative insulin sensitivity check index (QUICKI), homeostasis model assessment-insulin resistance (HOMA-IR) scores and WGDP were determined. The backward stepwise method was applied... περισσότερα »
Podcasting in the STEM disciplines: The implications of supplementary lecture recording and 'lecture flipping.
Lecture capture, or 'podcasting' technology offers a new and engaging format of learning materials that can be used to increase the flexibility and interactivity of learning and teaching environments. Here we discuss different ways that these recordings can be incorporated into STEM discipline teaching, and the impact this can have on students' learning. from Infection via ola Kala on Inoreader http://ift.tt/1l4YwTt via IFTTT
Comparing the temporal colonization and microbial diversity of showerhead biofilms in Hawai'i and Colorado
The household is a potential source of opportunistic pathogens to humans, a particularly critical issue for immunodeficient individuals. An important human-microbe interface is the biofilm that develops on showerhead surfaces. Once microbe-laden biofilms become aerosolized, they can potentially be inhaled into the lungs. Understanding how quickly a new showerhead becomes colonized would provide useful information to minimize exposure to potentially pathogenic environmental microbes. High school scientists sampled the inner surfaces of pre-existing and newly fitted showerheads mont... περισσότερα »
Simultaneous saccharification and fermentation of dilute alkaline-pretreated corn stover for enhanced butanol production by Clostridium saccharobutylicum DSM 13864
Simultaneous saccharification and fermentation (SSF) process was applied for biobutanol production by *Clostridium saccharobutylicum* DSM 13864 from corn stover (CS). The key influential factors in SSF process, including corn steep liquor concentration, dry biomass and enzyme loading, SSF temperature, inoculation size and pre-hydrolysis time were optimized. In 5-L bioreactor with SSF process, butanol titer and productivity of 12.3 g/L and 0.257 g/L/h were achieved at 48 h, which were 20.6% and 21.2% higher than those in separate hydrolysis and fermentation (SHF) respectively. The ...περισσότερα »
Fungal denitrification: Bipolaris sorokiniana exclusively denitrifies inorganic nitrogen in the presence and absence of oxygen
Fungi may play an important role in the production of the greenhouse gas nitrous oxide (N2O). *Bipolaris sorokiniana* is a ubiquitous saprobe found in soils worldwide, yet denitrification by this fungal strain has not previously been reported. We aimed to test if *B. sorokiniana* would produce N2O and CO2 in the presence of organic and inorganic forms of nitrogen (N) under micro-aerobic and anaerobic conditions. Nitrogen source (organic-N, inorganic-N, no-N control) significantly affected N2O and CO2 production both in the presence and absence of oxygen, which contrasts with bacte... περισσότερα »
Mélanonychies longitudinales
Publication date: Available online 12 January 2016 *Source:*Annales de Dermatologie et de Vénéréologie Author(s): I. Moulonguet, S. Goettmann-Bonvallot from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1SNkCYn via IFTTT
Ulcères de jambe au cours de la drépanocytose : étude rétrospective de 40 cas
Publication date: Available online 12 January 2016 *Source:*Annales de Dermatologie et de Vénéréologie Author(s): M. Ndiaye, S.O. Niang, A. Diop, M. Diallo, K. Diaz, F. Ly, P. Dioussé, B.A. Diatta, N.B. Seck, S. Diallo, M.T. Ndiaye, S. Diadie, M.T. Dieng, A. Kane IntroductionEn Afrique, les études consacrées aux ulcères de jambe (UJ) drépanocytaires sont rares. Les objectifs de notre travail étaient de déterminer les aspects épidémiologiques, diagnostiques et évolutifs des UJ au cours de la drépanocytose.Patients et méthodesUne étude rétrospective a été menée pendant 5ans dans trois...περισσότερα »
Vermicomposting of sludge from animal wastewater treatment plant mixed with cow dung or swine manure using Eisenia fetida
Abstract Vermicomposting of animal wastewater treatment plant sludge (S) mixed with cow dung (CD) or swine manure (SM) employing *Eisenia fetida* was tested. The numbers, weights, clitellum development, and cocoon production were monitored for 60 days at a detecting interval of 15 days. The results indicated that 100 % of the sludge can be the suitable food for growth and fecundity of *E. fetida*, while addition of CD or SM in sludge significantly (*P* < 0.05) increased the worm biomass and reproduction. The sludge amended with 40 % SM can be a great medium for the growth of *E. f...περισσότερα »
Metal induced inhalation exposure in urban population: A probabilistic approach
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 56 δευτερόλεπτα
Publication date: March 2016 Source:Atmospheric Environment, Volume 128 Author(s): Kamila Widziewicz, Krzysztof Loska The paper was aimed at assessing the health risk in the populations of three Silesian cities: Bielsko-Biała, Częstochowa and Katowice exposed to the inhalation intake of cadmium, nickel and arsenic present in airborne particulate matter. In order to establish how the exposure […]
Bilateral thalamic developmental venous variations (DVVs) draining into same internal cerebral vein: a case report and review with emphasis on DVVs with outflow restriction
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 56 δευτερόλεπτα
Abstract Developmental venous variations (DVVs) are anatomic variations of normal transmedullary veins which are often discovered incidentally. Although they are accepted as benign compensatory venous drainage systems, they may become symptomatic or clinically significant due to flow-related causes. The fragile venous drainage systems increase vulnerability to in–out flow alterations. Increased inflow or decreased outflow causes […]
Diagnosis of a C3 segmental type of vertebral artery by magnetic resonance angiography: report of two cases
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 56 δευτερόλεπτα
Abstract We report two cases in which the vertebral artery (VA) entered the spinal canal via the intervertebral foramen at the C2–C3 disc level, an extremely rare variation regarded as a C3 segmental type of VA, that we diagnosed by magnetic resonance angiography. The C2 segmental type of VA, in which the VA enters the […]
Replaced common hepatic artery from the superior mesenteric artery: multidetector computed tomography (MDCT) classification focused on pancreatic penetration and the course of travel
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 56 δευτερόλεπτα
Abstract Purpose We categorize the subtypes of the replaced common hepatic artery (RCHA) and evaluate the clinical implications. Methods Thirty-four cases of the RCHA were evaluated retrospectively using multidetector computed tomography. We categorized them into the three RCHA subtypes according to pancreatic penetration and the passing routes. The distance between the orifice of the superior […]
Editorial 2016
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 56 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1mWyEuU via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Meta-analysis of published efficacy and safety data for docetaxel in second-line treatment of patients with advanced non-small-cell lung cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 56 δευτερόλεπτα
Abstract Purpose To gain a better understanding of the impact of dose and other prognostic factors on safety and efficacy of docetaxel in second-line non-small-cell lung cancer patients. Methods A model-based meta‐analysis (MBMA) of a published docetaxel monotherapy data in 6085 second‐line non-small-cell lung cancer patients from 46 trials was conducted. Results The logit of […]
Researcher Interview: Jinghui Zhang
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 56 δευτερόλεπτα
Jinghui Zhang, Ph.D., Chair of the newly established Computational Biology Department at St. Jude Children’s Research Hospital, lead computational analyst for the Pediatric Cancer Genome Project (PCGP), and member of the St. Jude Faculty, spoke to Amy Blum for this Researcher Interview. Amy Blum: What is your primary area of expertise as a researcher? from […]
Genomic profiling of lower-grade gliomas uncovers cohesive disease groups: implications for diagnosis and treatment
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 56 δευτερόλεπτα
Lower-grade gliomas (including low- and intermediate-grade gliomas, World Health Organization grades II and III) are diffusely infiltrative neoplasms that arise most often in the cerebral hemispheres of adults… from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1nhpmJK via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Cumulative scores based on plasma D-dimer and serum albumin levels predict survival in esophageal squamous cell carcinoma patients treated with transthoracic esophagectomy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 56 δευτερόλεπτα
Recently, studies have shown that plasma D-dimer and serum albumin are prognostic markers for esophageal cancer. The purpose of this study was to evaluate a novel prognostic scoring system—DA score (combinatio… from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1nhpmJG via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The role of endoscopy in the diagnosis and treatment of inflammatory pancreatic fluid collections
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 56 δευτερόλεπτα
This is one of a series of statements discussing the use of GI endoscopy in common clinical situations. The Standards of Practice Committee of the American Society for Gastrointestinal Endoscopy (ASGE) prepared this text. In preparing this guideline, a search of the medical literature from January 1990 to February 2015 was performed by using PubMed. […]
Source apportionment of indoor PM10 in Elderly Care Centre
Abstract Source contribution to atmospheric particulate matter (PM) has been exhaustively modelled. However, people spend most of their time indoors where this approach is less explored. This evidence worsens considering elders living in Elderly Care Centres, since they are more susceptible. The present study aims to investigate the PM composition and sources influencing elderly exposure. Two 2-week sampling campaigns were conducted—one during early fall (warm phase) and another throughout the winter (cold phase). PM10 were collected with two TCR-Tecora® samplers that were located...περισσότερα »
Isolation and characterization of a hydrocarbonoclastic bacterial enrichment from total petroleum hydrocarbon contaminated sediments: potential candidates for bioaugmentation in bio-based processes
Abstract Seven hydrocarbonoclastic new bacterial isolates were isolated from dredged sediments of a river estuary in Italy. The sediments were contaminated by shipyard activities since decades, mainly ascribable to the exploitation of diesel oil as the fuel for recreational and commercial navigation of watercrafts. The bacterial isolates were able to utilize diesel oil as sole carbon source. Their metabolic capacities were evaluated by GC-MS analysis, with reference to the depletion of both the normal and branched alkanes, the *n*C18 fatty acid methyl ester and the unresolved compl... περισσότερα »
Toxicity of the mixture of selected antineoplastic drugs against aquatic primary producers
Abstract The residues of antineoplastic drugs are considered as new and emerging pollutants in aquatic environments. Recent experiments showed relatively high toxicity of 5-fluorouracil (5-FU), imatinib mesylate (IM), etoposide (ET) and cisplatin (CP) that are currently among most widely used antineoplastic drugs, against phytoplankton species. In this study, we investigated the toxic potential of the mixture of 5-FU + IM + ET against green alga *Pseudokirchneriella subcapitata* and cyanobacterium *Synechococcus leopoliensis,* and the stability and sorption of these drugs to algal ... περισσότερα »
Bioaugmentation in a pilot-scale constructed wetland to treat domestic wastewater in summer and autumn
Abstract In order to determine whether bioaugmentation is an effective technique in wetlands before the plants were harvested, the nitrogen (N) removal from a constructed wetland (CW) planted with *Phragmites* was evaluated after inoculating with *Paenibacillus* sp. XP1 in Northern China. The experiment was loaded with secondary effluent of rural domestic wastewater (RDW) using the batch-loaded method for over a 17-day period in summer and autumn. Chemical oxygen demand (CODcr), ammonia nitrogen (NH3-N), and total nitrogen (TN) decreased significantly in the CW with *Phragmites* i... περισσότερα »
Quantitative research into the deconditioning of hemodynamic to disorder of consciousness carried out using transcranial Doppler ultrasonography and photoplethysmography obtained via finger-transmissive absorption
Abstract In this study, transcranial Doppler ultrasonography (TCD) and photoplethysmography (PPG) have been utilized, through the observation of peripheral and cerebrovascular hemodynamic changes of the disorder of consciousness (DOC) patients, measured on clinical behavior scale of Coma Recovery Score-Revised (CRS-R) to obesrve their diagnostic value in evaluation of DOC patients. TCD ultrasound was used to evaluate the flow velocity and waveform patterns of middle cerebral artery (MCA), while PPG infrared signals were utilized to assess the peripheral circulation as a mean of me... περισσότερα »
A case of Horton's disease (with its potential neurological symptoms) depicted in a portrait by Andrea Mantegna
from Neurology via xlomafota13 on Inoreader http://ift.tt/1JJFVrL via IFTTT
No association between ApoE polymorphism and febrile seizures
Abstract Seizures associated with fever are a common pediatric problem, affecting about 2–7 % of children between 3 months and 5 years of age. Differentiation of febrile seizures from acute symptomatic seizures secondary to central nervous system infections or seizures associated with fever in children with epilepsy is essential to provide appropriate treatment and follow-up care. Here, we tested the hypothesis that children who exhibit simple febrile seizures during early childhood, but do not develop epileptic seizures later in life, might preferentially carry the ApoE2 allele o... περισσότερα »
Association study between IL-17A and IL-17F gene polymorphism and myasthenia gravis in Chinese patients
Abstract Alleles of IL-17A and IL-17F genes were reported to be associated with many inflammatory and autoimmune disorders in Asian patients. Serum level and mRNA of IL-17A in peripheral blood mononuclear cells were reported to be significantly higher in MG patients than in healthy controls. In experimental autoimmune myasthenia gravis (EAMG) animals, IL-17 may have effects on the severity of MG. This study investigated the association between four SNPs of IL-17A and IL-17F gene (rs8193036, rs2275913 and rs3748067 in IL-17A; rs763780 in IL-17F) and MG in Chinese patients. The alle... περισσότερα »
EEG frequency analysis of cortical brain activities induced by effect of light touch
Abstract In human postural control, touching a fingertip to a stable object with a slight force (<1 N) reduces postural sway independent of mechanical support, which is referred to as the effect of light touch (LT effect). The LT effect is achieved by the spatial orientation according to haptic feedback acquired from an external spatial reference. However, the neural mechanism of the LT effect is incompletely understood. Therefore, the purpose of this study was to employ EEG frequency analysis to investigate the cortical brain activity associated with the LT effect when attentional... περισσότερα »
Rewarding imperfect motor performance reduces adaptive changes
Abstract Could a pat on the back affect motor adaptation? Recent studies indeed suggest that rewards can boost motor adaptation. However, the rewards used were typically reward gradients that carried quite detailed information about performance. We investigated whether simple binary rewards affected how participants learned to correct for a visual rotation of performance feedback in a 3D pointing task. To do so, we asked participants to align their unseen hand with virtual target cubes in alternating blocks with and without spatial performance feedback. Forty participants were assi... περισσότερα »
In Parkinson’s disease on a probabilistic Go/NoGo task deep brain stimulation of the subthalamic nucleus only interferes with withholding of the most prepotent responses
Abstract The evidence on the impact of subthalamic nucleus deep brain stimulation (STN-DBS) on action restraint on Go/NoGO reaction time (RT) tasks in Parkinson's disease (PD) is inconsistent; with some studies reporting no effect and others finding that STN stimulation interferes with withholding of responses and results in more commission errors relative to STN-DBS off. We used a task in which the probability of Go stimuli varied from 100 % (simple RT task) to 80, 50 and 20 % (probabilistic Go/NoGo RT task), thus altering the prepotency of the response and the difficulty in withh... περισσότερα »
Trigeminocardiac reflex and haemodynamic changes during Le Fort I osteotomy
The Le Fort I osteotomy is performed under general anaesthesia and specific haemodynamic conditions, i.e. hypotensive general anaesthesia. This study assessed the incidence of the trigeminocardiac reflex (TCR) during the different stages of the Le Fort I osteotomy. Forty-seven patients requiring a Le Fort I osteotomy were included. General anaesthesia was induced. In terms of haemodynamic changes, each patient's oxygen saturation (SpO2), mean arterial pressure (MAP), heart rate (HR), and electrocardiogram (ECG) were monitored by SADAAT Monitoring System and recorded during the dif...περισσότερα »
Three-dimensional maxillary and mandibular regional superimposition using cone beam computed tomography: a validation study
This study aimed to validate a novel method for fast regional superimposition of cone beam computed tomography (CBCT) scans. The method can be used with smaller field of view scans, thereby allowing for a lower radiation dose. This retrospective study used two dry skulls and secondary data from 15 patients who had more than one scan taken using the same machine. Two observers tested two types of regional voxel-based superimposition: maxillary and mandibular. The registration took 10–15s. Three-dimensional surface models of the maxillas and mandibles were generated via standardized... περισσότερα »
Source apportionment of indoor PM10 in Elderly Care Centre
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Source contribution to atmospheric particulate matter (PM) has been exhaustively modelled. However, people spend most of their time indoors where this approach is less explored. This evidence worsens considering elders living in Elderly Care Centres, since they are more susceptible. The present study aims to investigate the PM composition and sources influencing elderly exposure. […]
Isolation and characterization of a hydrocarbonoclastic bacterial enrichment from total petroleum hydrocarbon contaminated sediments: potential candidates for bioaugmentation in bio-based processes
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Seven hydrocarbonoclastic new bacterial isolates were isolated from dredged sediments of a river estuary in Italy. The sediments were contaminated by shipyard activities since decades, mainly ascribable to the exploitation of diesel oil as the fuel for recreational and commercial navigation of watercrafts. The bacterial isolates were able to utilize diesel oil as sole […]
Toxicity of the mixture of selected antineoplastic drugs against aquatic primary producers
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract The residues of antineoplastic drugs are considered as new and emerging pollutants in aquatic environments. Recent experiments showed relatively high toxicity of 5-fluorouracil (5-FU), imatinib mesylate (IM), etoposide (ET) and cisplatin (CP) that are currently among most widely used antineoplastic drugs, against phytoplankton species. In this study, we investigated the toxic potential of the […]
Efficacy of EPAP
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
from #SleepMedicine via ola Kala on Inoreader http://ift.tt/1PVLTFp via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1W5ZKLz via IFTTT
A telehealth program for CPAP adherence reduces labor and yields similar adherence and efficacy when compared to standard of care
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Purpose This study evaluated the effectiveness and coaching labor requirements of a web-based automated telehealth (TH) messaging program compared with standard of care (SOC) in newly diagnosed patients with obstructive sleep apnea (OSA). Methods In this non-blinded, multicenter, prospective study, all patients were started on continuous positive airway pressure (CPAP) with heated humidification and […]
Bioaugmentation in a pilot-scale constructed wetland to treat domestic wastewater in summer and autumn
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract In order to determine whether bioaugmentation is an effective technique in wetlands before the plants were harvested, the nitrogen (N) removal from a constructed wetland (CW) planted with Phragmites was evaluated after inoculating with Paenibacillus sp. XP1 in Northern China. The experiment was loaded with secondary effluent of rural domestic wastewater (RDW) using the […]
Three-dimensional maxillary and mandibular regional superimposition using cone beam computed tomography: a validation study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
This study aimed to validate a novel method for fast regional superimposition of cone beam computed tomography (CBCT) scans. The method can be used with smaller field of view scans, thereby allowing for a lower radiation dose. This retrospective study used two dry skulls and secondary data from 15 patients who had more than one […]
Metal induced inhalation exposure in urban population: A probabilistic approach
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: March 2016 Source:Atmospheric Environment, Volume 128 Author(s): Kamila Widziewicz, Krzysztof Loska The paper was aimed at assessing the health risk in the populations of three Silesian cities: Bielsko-Biała, Częstochowa and Katowice exposed to the inhalation intake of cadmium, nickel and arsenic present in airborne particulate matter. In order to establish how the exposure […]
Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Background: Microglia and macrophages play a central role in neuroinflammation. Pro-inflammatory cytokines trigger their conversion to a classically activated (M1) phenotype, sustaining inflammation and producing a cytotoxic environment. Conversely, anti-inflammatory cytokines polarize the cells towards an alternatively activated (M2), tissue reparative phenotype. Elucidation of the signal transduction pathways involved in M1 to M2 phenotypic conversion […]
Spontaneous rupture of the long head of the biceps tendon in a woman with hypothyroidism: a case report
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Background Tendinitis can be a presenting complaint in hypothyroidism, with symptomatic relief being obtained by appropriate management of the primary thyroid deficiency. To the best of our knowledge no other cases of spontaneous rupture of the long head of the biceps tendon during uncontrolled hypothyroidism have yet been reported. Case presentation This case report […]
Efficacy of EPAP
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A telehealth program for CPAP adherence reduces labor and yields similar adherence and efficacy when compared to standard of care
Abstract Purpose This study evaluated the effectiveness and coaching labor requirements of a web-based automated telehealth (TH) messaging program compared with standard of care (SOC) in newly diagnosed patients with obstructive sleep apnea (OSA). Methods In this non-blinded, multicenter, prospective study, all patients were started on continuous positive airway pressure (CPAP) with heated humidification and a wireless modem. They all received standardized CPAP education and setup. Patients in the TH group (*n* = 58) received an automated series of text messages and/or e-mails th...περισσότερα »
Diagnosis of a C3 segmental type of vertebral artery by magnetic resonance angiography: report of two cases
Abstract We report two cases in which the vertebral artery (VA) entered the spinal canal via the intervertebral foramen at the C2–C3 disc level, an extremely rare variation regarded as a C3 segmental type of VA, that we diagnosed by magnetic resonance angiography. The C2 segmental type of VA, in which the VA enters the spinal canal via the C1–C2 intervertebral space, is relatively common. It is important to identify these variations before surgery of the craniovertebral junction or interventional procedures to prevent complications. from Anatomy Pathology via xlomafota13 on Inore... περισσότερα »
Replaced common hepatic artery from the superior mesenteric artery: multidetector computed tomography (MDCT) classification focused on pancreatic penetration and the course of travel
Abstract Purpose We categorize the subtypes of the replaced common hepatic artery (RCHA) and evaluate the clinical implications. Methods Thirty-four cases of the RCHA were evaluated retrospectively using multidetector computed tomography. We categorized them into the three RCHA subtypes according to pancreatic penetration and the passing routes. The distance between the orifice of the superior mesenteric artery (SMA) and RCHA bifurcation (*D* SMA-RCHA) was measured using advanced 3D imaging software. Analysis of variance was used to evaluate the difference in *D* SMA-RCHA accordi... περισσότερα »
Editorial 2016
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Composite Epstein-Barr Virus-Associated B-Cell Lymphoproliferative Disorder and Tubular Adenoma in a Rectal Polyp
Composite tumors are formed when there is intermingling between two components of separate tumors seen histologically. Cases demonstrating composite tubular adenoma with other types of tumors in the colon are rare. Composite tubular adenomas with nonlymphoid tumors including carcinoids, microcarcinoids, and small cell undifferentiated carcinoma have been reported in the literature. The occurrence of composite lymphoma and tubular adenoma within the colorectal tract is extremely rare. Only three cases have been reported and include one case of mantle cell lymphoma and two cases of ...περισσότερα »
Triad of Intraspinal Meningioma, Schwannoma, and Ependymoma: Report of an Extremely Rare Case
Mixed tumors composed of schwannoma and meningioma are extremely rare and are usually associated with neurofibromatosis type 2. So far, all the cases reported have involved the cerebellopontine angle. Only 3 reported cases did not have a clear association with neurofibromatosis type 2. We report a mixed tumor comprising schwannoma admixed with meningioma and ependymoma in the cervical spinal cord of a 22-year-old male. from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1P07e3p via IFTTT
Lymphocytic Infiltration as a Prognostic Factor in Patients With Colon Cancer
Host-defense mechanisms may have an important role in predicting the outcome of colorectal cancer patients. We designed our study to evaluate the possible prognostic significance of the presence of lymphocytic infiltration (LI) and subgroups of lymphocytes (CD3 and CD20) in the primary tumors. We randomly selected 195 patients operated for colorectal carcinoma from a larger cohort of 1527 patients with colorectal cancer. Histological slides were blindly reevaluated for the presence of LI that was graded 0 to 3. Immunohistochemical phenotyping of the lymphocytes was performed only ... περισσότερα »
Histology-Driven Therapy: The Importance of Diagnostic Accuracy in Guiding Systemic Therapy of Soft Tissue Tumors
Soft tissue tumors (STTs) are rare mesenchymal neoplasms accounting for less than 1% of adult cancers. More than 50 different subtypes of STTs have been identified, with this number expected to grow as our understanding of the complex genetic landscape of these diseases improves. As the classification of soft tissue neoplasms continues to diversify, so does the approach to therapy. Accurate histopathologic diagnosis, utilizing the appropriate ancillary immunohistochemical and molecular diagnostic platforms, underpins the oncologic management of soft tissue sarcomas. As increasing ...περισσότερα »
