Prognostic use of soluble fms-like tyrosine kinase-1 and placental growth factor in patients with coronary artery disease.
*Prognostic use of soluble fms-like tyrosine kinase-1 and placental growth factor in patients with coronary artery disease.* Biomark Med. 2015 Dec 7; Authors: Sinning C, Schnabel RB, Zeller T, Seiffert M, Rupprecht HJ, Lackner KJ, Blankenberg S, Bickel C, Westermann D Abstract BACKGROUND: Intention of the study is to assess the cardiovascular mortality of patients with coronary artery disease (CAD) with the biomarkers of angiogenesis PlGF and its endogenous inhibitor sFlt-1. METHODS: The cohort included n = 1848 patients with CAD and 282 subjects without CAD. In 85 patients cardi...περισσότερα »
Amentoflavone Induces Anti-angiogenic and Anti-metastatic Effects Through Suppression of NF-κB Activation in MCF-7 cells.
Related Articles *Amentoflavone Induces Anti-angiogenic and Anti-metastatic Effects Through Suppression of NF-κB Activation in MCF-7 cells.* Anticancer Res. 2015 Dec;35(12):6685-93 Authors: Chen JH, Chen WL, Liu YC Abstract The aim of the present study was to investigate whether amentoflavone induces anti-angiogenic and anti-metastatic effects through suppression of NF-κB activation in breast cancer in vitro. Effects of NF-κB inhibitor 4-N-[2-(4-phenoxyphenyl) ethyl] quinazoline-4, 6-diamine (QNZ) and amentoflavone on the expression and secretion of angiogenesis- and metastasis-...περισσότερα »
Targeting Fibroblast Growth Factor Receptor (FGFR) with BGJ398 in a Gastric Cancer Model.
Related Articles *Targeting Fibroblast Growth Factor Receptor (FGFR) with BGJ398 in a Gastric Cancer Model.* Anticancer Res. 2015 Dec;35(12):6655-65 Authors: Schmidt K, Moser C, Hellerbrand C, Zieker D, Wagner C, Redekopf J, Schlitt HJ, Geissler EK, Lang SA Abstract AIM: To assess the efficacy of targeting fibroblast growth factor receptor (FGFR) with the pan-FGFR inhibitor BGJ398 in a gastric cancer (GC) model. MATERIALS AND METHODS: Expression of FGFRs was determined in GC cell lines (KKLS, MKN-45, TMK-1). Impact of the FGFR inhibitor BGJ398 on growth, motility, signaling, expr... περισσότερα »
Psoriasis and uric acid: a population-based cross-sectional study
Summary Background Psoriasis has been reported to be associated with raised serum uric acid levels and gout, and uric acid has been demonstrated to mediate inflammatory pathways via secretion of pro-inflammatory chemokines. Aim To evaluate the association between psoriasis, serum uric acid levels and gout in a cross-sectional study using the US National Health and Nutrition Examination Survey (NHANES) database. Methods Data on clinical history of psoriasis, gout and other relevant medical conditions from the questionnaire as well as laboratory parameters for serum uric acid and...περισσότερα »
Malignant peripheral nerve sheath tumour arising in a scar from infantile haemangioma
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1lLKg2z via IFTTT
mRNA and protein expression of the angiogenesis-related genes EDIL3, AMOT and ECM1 in mesenchymal stem cells in psoriatic dermis
Summary Background Dermal microvasculature expansion and angiogenesis are prominent in psoriasis. Our previous microarray study showed that the angiogenesis-related genes *EDIL3* (epidermal growth factor-like repeats and discoidin I-like domains 3), *AMOT* (angiomotin) and *ECM1* (extracellular matrix protein 1), had high expression levels in dermal mesenchymal stem cells (DMSCs) from psoriatic skin lesions. Aim To investigate the mRNA and protein expressions of *EDIL3*, *AMOT* and *ECM1* in DMSCs derived from psoriatic skin in order to better determine the molecular mechanisms ... περισσότερα »
Successive MRI Findings of Reversible Cerebral White Matter Lesions in a Patient with Cystathionine β-Synthase Deficiency.
*Successive MRI Findings of Reversible Cerebral White Matter Lesions in a Patient with Cystathionine β-Synthase Deficiency.* Tohoku J Exp Med. 2015;237(4):323-7 Authors: Sasai H, Shimozawa N, Asano T, Kawamoto N, Yamamoto T, Kimura T, Kawamoto M, Matsui E, Fukao T Abstract Cystathionine β-synthase (CBS) deficiency, well known as classical homocystinuria, is a rare autosomal recessive inborn error of homocysteine and sulfur metabolism. CBS converts homocysteine to cystathionine. The clinical features of untreated CBS deficiency include myopia, ectopia lentis, mental retardation, ... περισσότερα »
A Community-Based Exercise and Support Group Program Improves Quality of Life in African-American Breast Cancer Survivors: A Quantitative and Qualitative Analysis.
*A Community-Based Exercise and Support Group Program Improves Quality of Life in African-American Breast Cancer Survivors: A Quantitative and Qualitative Analysis.* Int J Sports Exerc Med. 2015;1(3) Authors: Nock NL, Owusu C, Flocke S, Krejci SA, Kullman EL, Austin K, Bennett B, Cerne S, Harmon C, Moore H, Vargo M, Hergenroeder P, Malone H, Rocco M, Tracy R, Lazarus HM, Kirwan JP, Heyman E, Berger NA Abstract African-American (AA) breast cancer (BCa) survivors have higher mortality rates, more comorbidities and are less likely to meet national physical activity guidelines after...περισσότερα »
Neural dynamics of change detection in crowded acoustic scenes
Publication date: 1 February 2016 *Source:*NeuroImage, Volume 126 Author(s): Ediz Sohoglu, Maria Chait Two key questions concerning change detection in crowded acoustic environments are the extent to which cortical processing is specialized for different forms of acoustic change and when in the time-course of cortical processing neural activity becomes predictive of behavioral outcomes. Here, we address these issues by using magnetoencephalography (MEG) to probe the cortical dynamics of change detection in ongoing acoustic scenes containing as many as ten concurrent sources. Each so... περισσότερα »
Spatial properties of objects predict patterns of neural response in the ventral visual pathway
[image: S10538119.gif] Publication date: 1 February 2016 *Source:*NeuroImage, Volume 126 Author(s): David M. Watson, Andrew W. Young, Timothy J. Andrews Neuroimaging studies have revealed topographically organised patterns of response to different objects in the ventral visual pathway. These patterns are thought to be based on the form of the object. However, it is not clear what dimensions of object form are important. Here, we determined the extent to which spatial properties (energy across the image) could explain patterns of response in these regions. We compared patterns of fMRI...περισσότερα »
Heterogeneous and nonlinear development of human posterior parietal cortex function
[image: S10538119.gif] Publication date: 1 February 2016 *Source:*NeuroImage, Volume 126 Author(s): Ting-Ting Chang, Arron W.S. Metcalfe, Aarthi Padmanabhan, Tianwen Chen, Vinod Menon Human cognitive problem solving skills undergo complex experience-dependent changes from childhood to adulthood, yet most neurodevelopmental research has focused on linear changes with age. Here we challenge this limited view, and investigate spatially heterogeneous and nonlinear neurodevelopmental profiles between childhood, adolescence, and young adulthood, focusing on three cytoarchitectonically dis... περισσότερα »
Perception drives production across sensory modalities: A network for sensorimotor integration of visual speech
[image: S10538119.gif] Publication date: 1 February 2016 *Source:*NeuroImage, Volume 126 Author(s): Jonathan H. Venezia, Paul Fillmore, William Matchin, A. Lisette Isenberg, Gregory Hickok, Julius Fridriksson Sensory information is critical for movement control, both for defining the targets of actions and providing feedback during planning or ongoing movements. This holds for speech motor control as well, where both auditory and somatosensory information have been shown to play a key role. Recent clinical research demonstrates that individuals with severe speech production deficits...περισσότερα »
Ictal epileptic headache revealing non convulsive status epilepticus in a case of eyelid myoclonia with absences
Ictal epileptic headache revealing non convulsive status epilepticus in a case of eyelid myoclonia with absences: Epileptic seizures and headache attacks are two common neurologic phenomena characterized by paroxysmal alteration of brain functions followed by complete restauration of the baseline condition. Headache and epilepsy are related in numerous ways, and they often co-occur. Although the link between these two diseases is not completely clear, several clinical, physiopathological and therapeutic features overlap. Headache is reported in association with epileptic seizures as...περισσότερα »
Surgical treatment of acoustic neuroma
: Outcomes and indications via Reports of Practical Oncology & Radiotherapy Publication date: Available online 7 December 2015 *Source:*Reports of Practical Oncology & Radiotherapy Author(s): Elisabetta Zanoletti, Chiara Faccioli, Alessandro Martini AimSurgery for acoustic neuroma has developed over the years with a gradual improvement in outcome. The goal of surgery should be cure of the disease and a low morbidity, preserving facial nerve function – and hearing, too, whenever feasible (i.e. in small tumors). The most appropriate approach must be decided case by case.BackgroundResults ... περισσότερα »
Bisphosphonates and evidence for association with esophageal and gastric cancer: a systematic review and meta-analysis
Bisphosphonates and evidence for association with esophageal and gastric cancer: a systematic review and meta-analysis: Objectives Concerns have been raised about a possible link between bisphosphonate use, and in particular alendronate, and upper gastrointestinal (UGI) cancer. A number of epidemiological studies have been published with conflicting results. We conducted a systematic review and meta-analysis of observational studies, to determine the risk of esophageal and gastric cancer in users of bisphosphonates compared with non-users. Design We searched PubMed, MEDLINE, EMBASE...περισσότερα »
Do thyroid cancer incidence rates increase with socioeconomic status among people with health insurance? An observational study using SEER population-based data
Do US thyroid cancer incidence rates increase with socioeconomic status among people with health insurance? An observational study using SEER population-based data: Objectives The US thyroid cancer incidence rates are rising while mortality remains stable. Trends are driven by papillary thyroid cancer (PTC), the predominant cancer subtype which has a very good prognosis. We hypothesised that health insurance and high census tract socioeconomic status (SES) are associated with PTC risk. Design Relationships between thyroid cancer incidence, insurance and census tract SES during 200... περισσότερα »
Thyroid hormone and vitamin D regulate VGF expression and promoter activity
Thyroid hormone and vitamin D regulate VGF expression and promoter activity: The Siberian hamster (Phodopus sungorus) survives winter by decreasing food intake and catabolizing abdominal fat reserves, resulting in a sustained, profound loss of body weight. Hypothalamic tanycytes are pivotal for this process. In these cells, short winter photoperiods upregulate deiodinase 3, an enzyme which regulates thyroid hormone availability, and downregulate genes encoding components of retinoic acid uptake and signaling. The aim of the current studies was to identify mechanisms by which season...περισσότερα »
A warning to the Speech-Language Pathology and Audiology community about the importance of scientific and clinical activities in primary progressive aphasia
A warning to the Brazilian Speech-Language Pathology and Audiology community about the importance of scientific and clinical activities in primary progressive aphasia: RESUMO Este artigo tem como objetivo alertar a comunidade científica fonoaudiológica brasileira sobre a importância e necessidade da atuação científica e clínica a respeito da Afasia Progressiva Primária. Esse alerta é fundamentado em um levantamento bibliográfico sistemático da produção científica brasileira sobre Afasia Progressiva Primária, a partir do qual foram encontrados nove artigos brasileiros. Percebe-se que... περισσότερα »
Speech language therapy bilingual clinic, a written language therapeutical proposal to deaf people: case report
Speech language therapy bilingual clinic, a written language therapeutical proposal to deaf people: case report: RESUMO Objetivo: O objetivo deste estudo foi analisar produções escritas de um sujeito surdo em processo de apropriação da escrita. Métodos: Participou dessa pesquisa um sujeito surdo, reconhecido pela inicial R., em conjunto com a sua fonoaudióloga. Cabe esclarecer que tal profissional, proficiente em língua de sinais, atuou como interlocutora e intérprete, priorizando a natureza interativa da linguagem e interferindo nas produções escritas apenas quando solicitada. Resu...περισσότερα »
World Voice Day
World Voice Day in news: analysis of reports on the Voice Campaign in Brazil: RESUMO Objetivo: Analisar reportagens televisionadas sobre o Dia Mundial da Voz veiculadas pela TV Globo(r). Métodos: foram pesquisadas reportagens veiculadas pela emissora Globo(r) em telejornais regionais, no período de 15 de março a 20 de abril de 2013. Para análise dos dados utilizou-se a técnica de Análise Documental (AD), em que se destacavam as variáveis: localização, turno de veiculação, tempo de duração, profissional entrevistado, menção ao trabalho multiprofissional, orientações à população e o e... περισσότερα »
Vocal parameters in adult bilingual speakers
A comparison of vocal parameters in adult bilingual Hebrew-English speakers: ABSTRACT Purpose: There has been growing research on the effects of language on voice characteristics; however, few studies have examined the impact of language on vocal features within bilinguals. This study aimed to compare vocal parameters among bilingual Hebrew/English speaking individuals when speaking in Hebrew versus English. Methods: Forty bilingual participants (17 males and 23 females) between the ages of 23-60 years were asked to spontaneously speak about a neutral topic. Voice samples were digit... περισσότερα »
Analysis of tongue pressure in young adults
Analysis of tongue pressure in Brazilian young adults: RESUMO Objetivo: Apresentar valores para a pressão da língua em adultos jovens brasileiros, considerando provas específicas e possíveis diferenças quanto ao gênero e tipo de prova. Método: Foram avaliados 51 voluntários de 18 a 28 anos, ambos os gêneros, com boa relação dento-oclusal e sem alterações de fala. Utilizou-se o Iowa Oral Performance Instrument na avaliação da pressão da língua (Kilopascal) durante as provas de elevação, protrusão, deglutição e lateralização, além do teste de resistência (segundos). Na análise dos res...περισσότερα »
Study of the correlation between the linear measurements of the skull and face and palatal wide and length measures
Study of the correlation between the linear measurements of the skull and face and palatal wide and length measures: RESUMO Objetivo: Analisar a relação entre as medidas lineares antropométricas de crânio e face com as medidas de largura e comprimento do palato duro. Métodos: foram utilizados 23 crânios humanos e as medidas foram obtidas com o auxílio de um paquímetro e um pelvímetro. Foram mensuradas as seguintes medidas lineares: comprimento máximo do crânio, distância biporion, largura facial máxima, altura nasal, comprimento palatino e largura palatina. Resultados: Após a descri... περισσότερα »
Comparative analysis of velopharyngeal activity assessed by acoustic rhinometry and rhinomanometry
Comparative analysis of velopharyngeal activity assessed by acoustic rhinometry and rhinomanometry: RESUMO Objetivo: Analisar a atividade velofaríngea (VF) de indivíduos com disfunção velofaríngea (DVF) aferida por rinometria acústica, comparativamente à rinomanometria. Métodos: Estudo clínico prospectivo em 41 adultos, de ambos os gêneros, com fissura de palato±lábio previamente operada e DVF residual ao exame clínico, sem articulação compensatória nas plosivas surdas [p], [t] e [k]. Variáveis analisadas: (1) variação volumétrica da nasofaringe (∆V) na produção das três plosivas, r...περισσότερα »
Phonological short-term memory and phonological awareness in students from the Elementary School
Phonological short-term memory and phonological awareness in students from the Elementary School: RESUMO Objetivos: Caracterizar e comparar o desempenho de escolares no início e término (1° e 5° ano) do Ensino Fundamental I, nas habilidades de Memória de Curto Prazo Fonológica e Consciência Fonológica. Métodos: Foram avaliados 80 escolares, de ambos gêneros, com bom desempenho escolar e linguístico, sendo 40 do 1º ano e 40 do 5º ano de uma escola estadual com média de idade, respectivamente, de 6,2 e 9,8 anos. Para a avaliação da Memória de Curto Prazo Fonológica (MCPF) foi utilizad... περισσότερα »
Depressive signs and cognitive performance in patients with a right hemisphere stroke
Depressive signs and cognitive performance in patients with a right hemisphere stroke: ABSTRACT Purpose: This study investigated the influence of suggestive signs of depression (SSD) in right-hemisphere brain-damaged (RHD) patients following a stroke on their cognitive performance measured by a brief neuropsychological assessment battery. Methods: Forty-two adults with RHD after a single episode of stroke and 84 matched controls participated in this study. They were assessed by means of the Geriatric Depression Scale and by Brief Neuropsychological Assessment Battery NEUPSILIN. Resu... περισσότερα »
Vocabulary and verbal comprehension of students with Attention Deficit Hyperactivity Disorder
Vocabulary and verbal comprehension of students with Attention Deficit Hyperactivity Disorder: RESUMO Objetivo: Comparar o vocabulário receptivo e a compreensão verbal de escolares com e sem Transtorno do Déficit de Atenção e Hiperatividade (TDAH) e, ainda, confrontar o desempenho deles com os valores normativos dos testes aplicados. Métodos: 40 crianças em idade escolar com e sem TDAH foram submetidas a dois testes de linguagem receptiva, TVfusp e Token Test. Análise descritiva foi realizada, obtendo-se os valores de média, mediana, mínimo, máximo e quartis. Para uma análise compar... περισσότερα »
Oropharyngeal swallowing
Qualitative and quantitative ultrasound analysis of oropharyngeal swallowing: RESUMO Objetivo: Analisar a influência do efeito da consistência do alimento e da idade sobre os parâmetros qualitativos e/ou quantitativas no exame ultrassonográfico (USG) da deglutição. Métodos: Foram realizadas avaliações ultrassonográficas da deglutição em 100 indivíduos sadios (divididos em quatro grupos com idades entre 20 e 60 anos) nas consistências líquida e purê. Para análise qualitativa, considerou-se a presença de cinco etapas durante a deglutição orofaríngea. Para a análise quantitativa, foram... περισσότερα »
Influence of the educational status on the Dichotic Sentence Identification test
Influence of the educational status on the Dichotic Sentence Identification test in Brazilian Portuguese: RESUMO Objetivo: Comparar o desempenho, na versão em português brasileiro, do teste de identificação de sentenças dicóticas (DSI) entre: as orelhas direita e esquerda e escolaridade em indivíduos audiologicamente normais. Métodos: Foram avaliados 200 indivíduos normouvintes, destros, separados em sete grupos de acordo com os anos de escolaridade.Todos os sujeitos foram submetidos à audiológica básica e comportamental do processamento auditivo (teste de localização sonora, teste ...περισσότερα »
Interaction between diabetes mellitus and hypertension on hearing of elderly
Interaction between diabetes mellitus and hypertension on hearing of elderly: RESUMO Introdução: Doenças crônicas e alterações metabólicas podem atuar como fator de aceleração na degeneração do sistema auditivo decorrente da idade. No entanto, estudos envolvendo a associação entre a perda auditiva com a diabetes mellitus (DM) e com a hipertensão arterial (AH) em idosos mostraram conclusões controversas. Sendo assim, novos estudos sobre essa temática são necessários, a fim de elucidarmos o efeito dessas doenças crônicas sobre o sistema auditivo. Objetivo: Comparar os limiares auditivo...περισσότερα »
Figure-background in dichotic task and their relation to skills untrained
Figure-background in dichotic task and their relation to skills untrained: RESUMO Objetivos: Verificar a eficácia do treinamento auditivo em tarefa dicótica e comparar as respostas da habilidade treinada com as repostas das habilidades não treinadas, após quatro e oito semanas. Métodos: 19 indivíduos, de 12 a 15 anos foram submetidos a um treinamento auditivo baseado no DIID e organizados em 8 sessões, com duração de 50 minutos por sessão. Realizaram a avaliação do processamento auditivo em três momentos: pré-intervenção, pós-intervenção na metade e no final do treinamento. Os dados... περισσότερα »
Teleaudiology: efficacy assessment of an online social network as a support tool for parents of children candidates for cochlear implant
Teleaudiology: efficacy assessment of an online social network as a support tool for parents of children candidates for cochlear implant: RESUMO Objetivo: Avaliar a eficácia de uma rede social on-line como apoio aos pais de crianças com deficiência auditiva. Métodos: Vinte e duas mães, divididas randomicamente em grupo experimental (n=11) e controle (n=11), preencheram um formulário on-line contendo o Índice de Estresse Parental - versão reduzida (PSI-SF). Apenas o grupo experimental teve acesso à rede social "Portal dos Bebês". Ambos os grupos preencheram novamente o formulário on-... περισσότερα »
Combination Therapy with Refametinib plus Sorafenib in Patients with Advanced Cancer
A Phase I Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Combination Therapy with Refametinib plus Sorafenib in Patients with Advanced Cancer: Purpose: To assess the safety and tolerability of the small-molecule allosteric MEK inhibitor refametinib combined with sorafenib, in patients with advanced solid malignancies. Methods: This phase I dose-escalation study included an expansion phase at the maximum tolerated dose (MTD). Patients received refametinib/sorafenib twice daily (BID) for 28 days, from a dose of refametinib 5 mg plus sorafenib 200 mg to a dose of refam... περισσότερα »
New robotic intubation device
New robotic intubation device: [image: Ohio.jpg] A new development from Ohio State University: "With nearly 25 million intubations performed each year in the U.S., and at least 1 percent ending in failure, there is a pressing need for improved technology. So a team of Ohio State engineers began working with Dr. Hamdy Awad, an anesthesiologist at The Ohio State University Wexner Medical Center and associate professor in the College of Medicine. In addition to emergencies, patients need intubation when under general anesthesia to maintain an open airway during surgery. Encouraged... περισσότερα »
Otorhinolaryngological, audiovestibular and swallowing manifestations of patients with Niemann–Pick disease Type C,A proteomic characterization of NTHi lysates, Hospital cost of pediatric patients with complicated acute sinusitis, Improved behavior after adenotonsillectomy in children with higher and lower IQ
Otorhinolaryngological, audiovestibular and swallowing manifestations of patients with Niemann–Pick disease Type C Publication date: January 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 80 Author(s): Rezarta Taga Senirli, Oğuz Kuşçu, Umut Akyol, Meral Topçu, Öznur Yiğit, Songül Aksoy, Numan Demir Objectives The aim of this study is to evaluate audiovestibular and swallowing impairment of patients with NPC. Methods Audiovestibular and swallowing evaluation were performed on patients with Niemann–Pick disease type C (NPC) at Hacettepe University between ... περισσότερα »
Airway Problems in Children with Down's Syndrome
The Prevalence of via Pediatric Otorhinolaryngology Publication date: Available online 8 December 2015 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Jane Hamilton, May Maxime Corazon Yaneza, William Andrew Clement, Haytham Kubba AimAirway disorders are common in children with Down's Syndrome. We report the findings on airway endoscopy in a birth cohort of children from a well-defined geographical area, in order to estimate true population prevalence of airway problems in children with Down's Syndrome.MethodRetrospective case note review over a 20-year peri... περισσότερα »
Malignant peripheral nerve sheath tumour arising in a scar from infantile haemangioma
Malignant peripheral nerve sheath tumour arising in a scar from infantile haemangioma:
Prasugrel for Sickle Cell Vaso-Occlusive Events
A Multinational Trial of Prasugrel for Sickle Cell Vaso-Occlusive Events: Sickle cell anemia, which is estimated to affect 100 million persons worldwide, is an inherited blood disorder characterized by hemolytic anemia and recurrent vaso-occlusive crises that are associated with hospitalizations, impaired quality of life, and early death. The pathophysiological mechanism…
The effect of oral administration of dsRNA on viral replication and mortality
The effect of oral administration of dsRNA on viral replication and mortality in Bombus terrestris: Israeli acute paralysis virus (IAPV), a single-stranded RNA virus, has a worldwide distribution and affects honeybees as well as other important pollinators. IAPV infection in honeybees has been successfully repressed by exploiting the RNA interference (RNAi) pathway of the insect's innate immune response with virus-specific double stranded RNA (dsRNA). Here we investigated the effect of IAPV infection in the bumblebee Bombus terrestris and its tissue tropism. B. terrestris is a commo... περισσότερα »
TLR4 drives the pathogenesis of acquired cholesteatoma by promoting local inflammation and bone destruction.
TLR4 drives the pathogenesis of acquired cholesteatoma by promoting local inflammation and bone destruction.: *TLR4 drives the pathogenesis of acquired cholesteatoma by promoting local inflammation and bone destruction.* Sci Rep. 2015;5:16683 Authors: Si Y, Chen YB, Chen SJ, Zheng YQ, Liu X, Liu Y, Jiang HL, Xu G, Li ZH, Huang QH, Xiong H, Zhang ZG Abstract Acquired cholesteatoma is a chronic inflammatory disease characterized by both hyperkeratinized squamous epithelial overgrowth and bone destruction. Toll-like receptor (TLR) activation and subsequent inflammatory cytokine pro...περισσότερα »
A Hierarchical Generative Framework of Language Processing: Linking Language Perception, Interpretation, and Production Abnormalities in Schizophrenia.
A Hierarchical Generative Framework of Language Processing: Linking Language Perception, Interpretation, and Production Abnormalities in Schizophrenia.: *A Hierarchical Generative Framework of Language Processing: Linking Language Perception, Interpretation, and Production Abnormalities in Schizophrenia.* Front Hum Neurosci. 2015;9:643 Authors: Brown M, Kuperberg GR Abstract Language and thought dysfunction are central to the schizophrenia syndrome. They are evident in the major symptoms of psychosis itself, particularly as disorganized language output (positive thought disorder...περισσότερα »
Acoustic-Emergent Phonology in the Amplitude Envelope of Child-Directed Speech.
Acoustic-Emergent Phonology in the Amplitude Envelope of Child-Directed Speech.: *Acoustic-Emergent Phonology in the Amplitude Envelope of Child-Directed Speech.* PLoS One. 2015;10(12):e0144411 Authors: Leong V, Goswami U Abstract When acquiring language, young children may use acoustic spectro-temporal patterns in speech to derive phonological units in spoken language (e.g., prosodic stress patterns, syllables, phonemes). Children appear to learn acoustic-phonological mappings rapidly, without direct instruction, yet the underlying developmental mechanisms remain unclear. Acros... περισσότερα »
Cortical tracking of hierarchical linguistic structures in connected speech.
Cortical tracking of hierarchical linguistic structures in connected speech.: *Cortical tracking of hierarchical linguistic structures in connected speech.* Nat Neurosci. 2015 Dec 7; Authors: Ding N, Melloni L, Zhang H, Tian X, Poeppel D Abstract The most critical attribute of human language is its unbounded combinatorial nature: smaller elements can be combined into larger structures on the basis of a grammatical system, resulting in a hierarchy of linguistic units, such as words, phrases and sentences. Mentally parsing and representing such structures, however, poses challenge...περισσότερα »
Nodular histiocytic/mesothelial hyperplasia as consequence of chronic mesothelium irritation by subphrenic abscess.
*Nodular histiocytic/mesothelial hyperplasia as consequence of chronic mesothelium irritation by subphrenic abscess.* Future Oncol. 2015 Nov;11(24 Suppl):51-5 Authors: Cabibi D, Lo Iacono G, Raffaele F, Dioguardi S, Ingrao S, Pirrotta A, Fatica F, Cajozzo M Abstract PURPOSE: Pleural nodular histiocytic/mesothelial hyperplasia is a nodular histiocytic/mesothelial proliferation, often delimiting cystic cavities, due to irritation by a pulmonary noxa. Case report results: The patient had right pleural parietal and diaphragmatic thickness, with pleural effusion, without lung alterat...περισσότερα »
Elastofibroma dorsi and the thoracic surgeon: experience with 13 patients.
*Elastofibroma dorsi and the thoracic surgeon: experience with 13 patients.* Future Oncol. 2015 Nov;11(24 Suppl):47-50 Authors: Criscione A, Palmucci S, Calvo D, Magro G, Coronella M, Piccoli M, Lanza ML, Roccasalva F, Caltabiano R, Basile G, Migliore M Abstract A total of 13 patients (11 females, average age of 63 years) with elastofibromadorsi were retrospectively analyzed. The disease was confirmed by surgical intervention in five cases. In other patients (n = 8) the diagnosis was achieved on the basis of clinical and radiological features. Typical imaging features allow for t... περισσότερα »
Preliminary experience with video-assisted thoracic surgery lobectomy for lung malignancies: general considerations moving toward standard practice.
*Preliminary experience with video-assisted thoracic surgery lobectomy for lung malignancies: general considerations moving toward standard practice.* Future Oncol. 2015 Nov;11(24 Suppl):43-6 Authors: Migliore M, Criscione A, Calvo D, Borrata F, Gangemi M, Attinà G Abstract As part of the Second Catania Symposium on Thoracic Oncology, as we started the experience with video-assisted thoracic surgery (VATS) lobectomy for lung malignancies, we reviewed our data and argued some comments in a more general discussion. Operated patients with non-small-cell lung cancer were divided in t...περισσότερα »
Thoracoscopy in pleural effusion - two techniques: awake single-access video-assisted thoracic surgery versus 2-ports video-assisted thoracic surgery under general anesthesia.
*Thoracoscopy in pleural effusion - two techniques: awake single-access video-assisted thoracic surgery versus 2-ports video-assisted thoracic surgery under general anesthesia.* Future Oncol. 2015 Nov;11(24 Suppl):39-41 Authors: Cajozzo M, Lo Iacono G, Raffaele F, Anzalone AA, Fatica F, Geraci G, Dioguardi S Abstract UNLABELLED: Awake single access video-assisted thoracic surgery with local anesthesia improves procedure tolerance, reduces postoperative stay and costs. MATERIALS & METHODS: Local anesthesia was made with lidocaine and ropivacaine. We realize one 20 mm incision for... περισσότερα »
FBLN-3 as a biomarker of pleural plaques in workers occupationally exposed to carcinogenic fibers: a pilot study.
*FBLN-3 as a biomarker of pleural plaques in workers occupationally exposed to carcinogenic fibers: a pilot study.* Future Oncol. 2015 Nov;11(24 Suppl):35-7 Authors: Rapisarda V, Ledda C, Migliore M, Salemi R, Musumeci A, Bracci M, Marconi A, Loreto C, Libra M Abstract FBLN-3 has recently been proposed as a biomarker for malignant mesothelioma. A significantly increased standardized mortality rate from malignant mesothelioma has been reported in Biancavilla, Italy. Its cause has been identified in environmental exposure to fluoro-edenite. The aim of this study was to seek a corr...περισσότερα »
Biomarkers and prognostic factors for malignant pleural mesothelioma.
*Biomarkers and prognostic factors for malignant pleural mesothelioma.* Future Oncol. 2015 Nov;11(24 Suppl):29-33 Authors: Vigneri P, Martorana F, Manzella L, Stella S Abstract The increasing incidence and the dismal prognosis of malignant pleural mesothelioma calls for the identification of biomarkers that will allow a timely diagnosis; display prognostic value; and, predict the response to pharmacological agents employed for the treatment of the disease. Biomarkers associated with early diagnosis currently include mesothelin in combination with miRNA miR-103a-3p. As for prognos...περισσότερα »
Management of recurrence after initial surgery for malignant pleural mesothelioma: a mini-review.
*Management of recurrence after initial surgery for malignant pleural mesothelioma: a mini-review.* Future Oncol. 2015 Nov;11(24 Suppl):23-7 Authors: Halezeroğlu S, Migliore M Abstract Recurrence after surgery in the multimodality therapy for malignant pleural mesothelioma is a common problem. As the majority of patients experience not only local but also distant metastases, a systemic treatment strategy in addition to local control measures remains necessary. Nevertheless, none of the chemotherapy regimens have achieved clinical success. Local management modalities such as ster... περισσότερα »
Pleurectomy/decortication and hyperthermic intrapleural chemotherapy for malignant pleural mesothelioma: initial experience.
*Pleurectomy/decortication and hyperthermic intrapleural chemotherapy for malignant pleural mesothelioma: initial experience.* Future Oncol. 2015 Nov;11(24 Suppl):19-22 Authors: Migliore M, Calvo D, Criscione A, Palmucci S, Fuccio Sanzà G, Caltabiano R, Spatola C, Privitera G, Aiello MM, Parra HS, Ciancio N, Di Maria G Abstract Cytoreductive surgery and hyperthermic intraoperative intrapleural chemotherapy (HITHOC) are a known option for malignant pleural mesothelioma (MPM). This prospective study was started to prove that pleurectomy/decortication and HITHOC could be successful...περισσότερα »
The imbalance of masticatory muscle activity affects the asymmetric growth of condylar cartilage and subchondral bone
in rats via Oral Biology Publication date: March 2016 *Source:*Archives of Oral Biology, Volume 63 Author(s): Mutsumi Miyazaki, Ikuo Yonemitsu, Maki Takei, Ikuko Kure-Hattori, Takashi Ono ObjectiveTo examine the effects of imbalance of masticatory muscle activity of the rat mandible on the condylar cartilage and subchondral bone during the growth period.DesignForty 5-week-old male Wistar rats were randomly divided into experimental (n=20) and control (n=20) groups. In the experimental group, the left masseter muscles were resected. The rats were sacrificed at 7 or 9 weeks of age in b...περισσότερα »
Suprasellar Primitive Neuroectodermal Tumor in an Adult.
Suprasellar Primitive Neuroectodermal Tumor in an Adult.: Primitive neuroectodermal tumors (PNET) of the central nervous system (CNS) are a heterogeneous group of embryonal malignancies that are composed of undifferentiated or poorly differentiated neuroepithelial cells. Supratentorial PNET is the second most common CNS embryonal malignancy in children, but it is rare in adults. We report the case of a 31-year-old woman with bilateral vision loss and a bitemporal hemianopia. Neuroimaging revealed a suprasellar mass, and pathology was consistent with PNET. After surgical debulking of... περισσότερα »
Optic Nerve Sheath Melanoma Presenting as a Central Retinal Vein Occlusion.
Optic Nerve Sheath Melanoma Presenting as a Central Retinal Vein Occlusion.: A 64-year-old woman, with a history of diabetes and melanoma, developed a central retinal vein occlusion (CRVO) in her left eye. On exam, she had severe disc edema with retinal nerve fiber layer thickening, and anterior deformation of the peripapillary retinal pigment epithelium (RPE)/Bruch membrane layer (ppRPE/BM) toward the vitreous on spectral domain optical coherence tomography (SD-OCT) suggesting an optic nerve sheath (ONS) meningioma. Magnetic resonance imaging findings and ONS biopsy later confirmed... περισσότερα »
The Optic Canal Size Is Associated With the Severity of Papilledema and Poor Visual Function in Idiopathic Intracranial Hypertension.
The Optic Canal Size Is Associated With the Severity of Papilledema and Poor Visual Function in Idiopathic Intracranial Hypertension.: Background: To determine whether the size of the bony optic canal is associated with the severity of papilledema and poor visual function in idiopathic intracranial hypertension (IIH). Methods: We performed a retrospective review of definite patients with IIH with requisite brain magnetic resonance imaging allowing for optic canal measurement. Clinical characteristics and automated (Humphrey) visual field results were reviewed; papilledema was graded ...περισσότερα »
Chronic Myelogenous Leukemia Relapse Presenting With CNS Blast Crisis and Bilateral Optic Nerve Infiltration.
Chronic Myelogenous Leukemia Relapse Presenting With CNS Blast Crisis and Bilateral Optic Nerve Infiltration.: Bilateral, simultaneous optic nerve sheath infiltration as a manifestation of leukemia relapse is very rare. A 45-year-old woman with chronic myelogenous leukemia was successfully treated to cytogenetic bone marrow remission 1 year previously and maintained on imatinib. She developed total bilateral blindness with marked, bilateral optic disc edema and evidence of bilateral optic nerve infiltration on magnetic resonance imaging. Cerebrospinal fluid cytology confirmed centra... περισσότερα »
Loss of E2F1 Extends Survival and Accelerates Oral Tumor Growth in HPV-Positive Mice
Cancers, Vol. 7, Pages 2372-2385: Loss of E2F1 Extends Survival and Accelerates Oral Tumor Growth in HPV-Positive Mice: The Human Papillomavirus (HPV) is associated with several human cancers, including head and neck squamous cell carcinomas (HNSCCs). HPV expresses the viral oncogene E7 that binds to the retinoblastoma protein (RB1) in order to activate the E2F pathway. RB1 can mediate contradictory pathways—cell growth and cell death via E2F family members. Here, we assessed the extent to which E2F1 mediates lethality of HPV oncogenes. Ubiquitous expression of the HPV oncogenes E6 ... περισσότερα »
Contribution of synovial lining cells to synovial vascularization of the rat temporomandibular joint
Contribution of synovial lining cells to synovial vascularization of the rat temporomandibular joint: Abstract The lining layer of the synovial membrane in the temporomandibular joint (TMJ) contains two types of lining cells: macrophage-like type A and fibroblast-like type B cells. The type B cells are particularly heterogeneous in their morphology and immunoreactivity, so that details of their functions remain unclear. Some of the type B cells exhibit certain resemblances in their ultrastructure to those of an activated capillary pericyte at the initial stage of the angiogenesis. ... περισσότερα »
Snake and Spider Toxins Induce a Rapid Recovery of Function of Botulinum Neurotoxin Paralysed Neuromuscular Junction
Toxins, Vol. 7, Pages 5322-5336: Snake and Spider Toxins Induce a Rapid Recovery of Function of Botulinum Neurotoxin Paralysed Neuromuscular Junction: Botulinum neurotoxins (BoNTs) and some animal neurotoxins (β-Bungarotoxin, β-Btx, from elapid snakes and α-Latrotoxin, α-Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes in patients. However, their mechanism of action is different, leading to a largely-different duration of neuromuscular junction (NMJ) blockade. BoNTs induce a long-lasting paralysis without n...περισσότερα »
Tracheal Ulcers Due to Endotracheal Tube Cuff Pressure
Tracheal Ulcers Due to Endotracheal Tube Cuff Pressure: [image: image]Tracheal injury is a well-known complication of endotracheal intubation. We present a case of a 73-year-old man who underwent craniotomy because of parenchymal hemorrhage involving the left hemisphere. After the surgical procedure, he was admitted to the intensive care unit. Bronchoscopy-guided percutaneous dilational tracheostomy was performed on day 8 of mechanical ventilation. During the procedure, tracheal ulcers were found affecting the anterior tracheal wall. The site of the lesions corresponded to the site w... περισσότερα »
Transpulmonary Artery Needle Aspiration of Hilar Masses With Endobronchial Ultrasound: A Necessary Evil
Transpulmonary Artery Needle Aspiration of Hilar Masses With Endobronchial Ultrasound: A Necessary Evil: [image: image]The safety with regard to bleeding complications of endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) of hilar and mediastinal lymphadenopathy has been well established. The real-time visualization of targeted and surrounding structures allows the operator to avoid puncturing even small vessels. However, on occasions, the only way to reach the target is by traversing vessels. We report 2 cases of right hilar masses that were successfully diagnose...περισσότερα »
Stress “Deafness” Reveals Absence of Lexical Marking of Stress or Tone in the Adult Grammar
by Hamed Rahmani, Toni Rietveld, Carlos Gussenhoven A Sequence Recall Task with disyllabic stimuli contrasting either for the location of prosodic prominence or for the medial consonant was administered to 150 subjects equally divided over five language groups. Scores showed a significant interaction between type of contrast and language group, such that groups did not differ on their performance on the consonant contrast, while two language groups, Dutch and Japanese, significantly outperformed the three other language groups (French, Indonesian and Persian) on the prosodic contra...περισσότερα »
Clinico-pathological Characteristics Associated With BRAFK601E and BRAFL597 Mutations in Melanoma
Clinico-pathological Characteristics Associated With BRAFK601E and BRAFL597 Mutations in Melanoma: Summary *BRAF* mutations at codons L597 and K601 occur uncommonly in melanoma. Clinical and pathological associations of these mutations were investigated in a cohort of 1,119 patients with known *BRAF* mutation status. A *BRAF* mutation was identified in 435 patients; Mutations at L597 and the K601E mutation were seen in 3.4% and 3.2% of these, respectively. K601E melanomas tended to occur in male patients, a median age of 58 years, were generally found on the trunk (64%) and uncommo... περισσότερα »
What is the Most Appropriate Intraoperative Baseline Parathormone?
What is the Most Appropriate Intraoperative Baseline Parathormone? A Prospective Cohort study.: *What is the Most Appropriate Intraoperative Baseline Parathormone? A Prospective Cohort study.* Int J Surg. 2015 ; Authors: Garbutt L, Sigvaldason H, Sharaf Eldin MH, Dembinski T, Nason RW, Pathak KA Abstract INTRODUCTION: The time of drawing pre-incision intraoperative parathyroid hormone (ioPTH) is crucial to provide the right baseline for post-excision PTH measurement. The objective of this study was to identify the optimal time and the numbers of baseline PTH samples that best pr... περισσότερα »
Oral Oncology
MicroRNA-31 upregulation predicts increased risk of progression of oral potentially malignant disorder Publication date: Available online 7 December 2015 *Source:*Oral Oncology Author(s): Kai-Feng Hung, Chung-Ji Liu, Peng-Chih Chiu, Jiun-Sheng Lin, Kuo-Wei Chang, Wen-Yu Shih, Shou-Yen Kao, Hsi-Feng Tu Objectives MicroRNAs (miRNAs, miRs) have shown diagnostic and prognostic potential for oral cancer but their role in oral potentially malignant disorder (OPMD) has been less investigated. We aimed to assess whether miR-21and miR-31, two of the most relevant miRNAs in oral cancer, are u...περισσότερα »
Lymphangioleiomyomatosis diagnosed by effusion cytology
Lymphangioleiomyomatosis diagnosed by effusion cytology: A case report: *Glorimar Rivera, Tunc Gokaslan, Elizabeth M Kurian* Journal of Cytology 2015 32(4):287-289 Lymphangioleiomyomatosis (LAM) is a rare lung disease traditionally affecting women during their childbearing years. It can be sporadic or be associated with tuberous sclerosis syndrome. It is usually manifested in the lungs, kidneys, and/or lymphatic system. It consists of an overgrowth of abnormal smooth muscle-like cells, usually along the bronchovascular structures, resulting in the formation of cysts and the dest... περισσότερα »
Bilaterally enlarged parotids and sicca symptoms as a presentation of sarcoidosis: Pivotal role of aspiration cytology in diagnosis
Bilaterally enlarged parotids and sicca symptoms as a presentation of sarcoidosis: Pivotal role of aspiration cytology in diagnosis: *Tanya Sharma, Deepti Joshi, Alkesh Khurana, Vikas Gupta, Neelkamal Kapoor* Journal of Cytology 2015 32(4):281-283 Sarcoidosis is a chronic multisystem inflammatory disease of unknown etiology characterized by widespread noncaseating granulomas in various organs. The diagnosis of sarcoidosis is based on cytological, clinicolaboratory, and radiological findings, and requires careful exclusion of other granulomatous diseases especially tuberculosis. ...περισσότερα »
Comparative cytomorphometric analysis of oral mucosal cells in normal, tobacco users, oral leukoplakia and oral squamous cell carcinoma
Comparative cytomorphometric analysis of oral mucosal cells in normal, tobacco users, oral leukoplakia and oral squamous cell carcinoma: *Mahadoon Nivia, Sukumaran Nair Sunil, Ravindran Rathy, Thapasimuthu Vijayamma Anilkumar* Journal of Cytology 2015 32(4):253-260 Background: Squamous cell carcinoma (SCC) is the third most common cause of oral morbidity in India despite the numerous advances made in the treatment protocol. Aim: To compare the cytomorphometric changes of oral mucosal cells in normal subjects (Group I) with that of tobacco users without any lesion (Group II), to...περισσότερα »
Optimization of FNAC findings as a preoperative diagnostic aid for odontogenic cysts
Optimization of FNAC findings as a preoperative diagnostic aid for odontogenic cysts: *Garima Jain, Pushparaja Shetty* Journal of Cytology 2015 32(4):248-252 Background: Fine-needle aspiration cytology (FNAC) is not a definitive preoperative diagnostic procedure done for all cases of odontogenic cysts. This is because of the inconsistent results obtained with it. Aims: This study was done to optimize FNAC findings and help in preoperative characterization of odontogenic cysts. Materials and Methods: Cystic fluid was collected and centrifuged from 50 odontogenic cysts that were pl... περισσότερα »
Langerhans cell histiocytosis in children diagnosed by fine-needle aspiration
Langerhans cell histiocytosis in children diagnosed by fine-needle aspiration: *Uma Handa, Reetu Kundu, Rajpal Singh Punia, Harsh Mohan* Journal of Cytology 2015 32(4):244-247 Background: Langerhans cell histiocytosis (LCH) is a rare intricate pediatric neoplasm with varied clinical manifestations and multiple treatment modalities. Aim: To study the cytological features of LCH and the differential diagnoses on fine-needle aspiration (FNA). Materials and Methods: FNA was performed using a 23-gauge needle fitted to a 10 mL syringe mounted on syringe holder. LCH was diagnosed on FNA...περισσότερα »
FNAC accuracy in diagnosis of thyroid neoplasms considering all diagnostic categories of the Bethesda reporting system: A single-institute experience
FNAC accuracy in diagnosis of thyroid neoplasms considering all diagnostic categories of the Bethesda reporting system: A single-institute experience: *Fatemeh Hajmanoochehri, Elham Rabiee* Journal of Cytology 2015 32(4):238-243 Background: Thyroid fine-needle aspiration cytology (FNAC) is a valuable test used for diagnosing diseases of the thyroid gland. Aims: Using all satisfactory categories of the Bethesda system, this study aimed to determine the accuracy with which FNAC diagnoses thyroid neoplasms. We also discuss the factors that affect diagnosis accuracy. Settings and Des... περισσότερα »
A case of papillary microcarcinoma of the thyroid with abundant colloid (masquerading as colloid goiter with papillary hyperplasia): Cytological evaluation with histopathological correlation
A case of papillary microcarcinoma of the thyroid with abundant colloid (masquerading as colloid goiter with papillary hyperplasia): Cytological evaluation with histopathological correlation: *Elancheran Muthalagan, Priya Subashchandrabose, Priya Banthavi Sivasubramanian, Sarada Venkateswaran* Journal of Cytology 2015 32(4):278-280 Papillary thyroid carcinoma (PTC) is the most common malignant neoplasm of the thyroid. On fine-needle aspiration (FNA) cytology smears of conventional PTC, the background usually shows scanty, bubble gum-like colloid. But the macrofollicular variant...περισσότερα »
S-100 Negative Granular Cell Tumor of the Oral Cavity
S-100 Negative Granular Cell Tumor of the Oral Cavity: AbstractClassic granular cell tumor is a mesenchymal neoplasm that commonly occurs on the skin, but is not infrequently found in the oral cavity, primarily on the dorsal tongue. Diagnosis is usually straightforward with hematoxylin and eosin stained slides. Immunohistochemical studies on classic granular cell tumor shows positive immunostaining for S-100 and vimentin, while CD68 is variably positive. We report a case of otherwise unremarkable oral granular cell tumor that was immunohistochemically negative for S-100, and positi... περισσότερα »
Stress “Deafness” Reveals Absence of Lexical Marking of Stress or Tone in the Adult Grammar
Stress “Deafness” Reveals Absence of Lexical Marking of Stress or Tone in the Adult Grammar: by Hamed Rahmani, Toni Rietveld, Carlos Gussenhoven A Sequence Recall Task with disyllabic stimuli contrasting either for the location of prosodic prominence or for the medial consonant was administered to 150 subjects equally divided over five language groups. Scores showed a significant interaction between type of contrast and language group, such that groups did not differ on their performance on the consonant contrast, while two language groups, Dutch and Japanese, significantly outper...περισσότερα »
Screening for Helicobacter pylori in Idiopathic Pulmonary Fibrosis Lung Biopsies
Screening for Helicobacter pylori in Idiopathic Pulmonary Fibrosis Lung Biopsies: *Background:* Increasing evidence suggests a role of gastro-oesophageal reflux (GER) in idiopathic pulmonary fibrosis (IPF) pathogenesis. Recently, an association between serum *Helicobacter pylori* (HP) antibody positivity and more severe disease was described, but HP has not been directly analysed in lung tissue so far. *Objective:* To investigate the presence of HP in the lung tissue of IPF patients. *Methods:* Two tertiary interstitial lung disease care centre databases were screened for available ... περισσότερα »
Visual Assessment of Age-Related White Matter Hyperintensities Using FLAIR Images at 3 T: Inter- and Intra-Rater Agreement
Visual Assessment of Age-Related White Matter Hyperintensities Using FLAIR Images at 3 T: Inter- and Intra-Rater Agreement: *Background:* Age-related white matter hyperintensities are frequent incidental findings on T2-weighted brain MRI, and they are evaluated in clinical practice using a visual rating scale. *Objective:* To evaluate inter- and intra-rater agreement in MRI visual evaluations of age-related white matter hyperintensities made by two radiologists with different levels of experience using a visual rating scale. *Methods:* Two radiologists of two different levels of exp... περισσότερα »
The MesoVATS trial: is there a future for video-assisted thoracoscopic surgery partial pleurectomy?
*The MesoVATS trial: is there a future for video-assisted thoracoscopic surgery partial pleurectomy?* Future Oncol. 2015 Nov;11(24 Suppl):15-7 Authors: Rintoul RC Abstract Malignant pleural mesothelioma, a uniformly fatal cancer caused by prior asbestos exposure, places a major burden on society. The MesoVATS trial was a multicenter randomized controlled trial that examined the role of video-assisted thoracoscopic partial pleurectomy (VAT-PP) versus talc pleurodesis in patients with malignant pleural mesothelioma. Overall there was no difference in survival between VAT-PP and ta... περισσότερα »
Is the patient with mesothelioma without hope?
*Is the patient with mesothelioma without hope?* Future Oncol. 2015 Nov;11(24 Suppl):11-4 Authors: Maat AP, Cornelissen R, Bogers AJ, Takkenberg JJ Abstract Hope is a very important mindset for malignant pleural mesothelioma patients as their cancer has a grim prognosis and limited therapeutic options. In this paper, we briefly discuss what hope means for a patient and how hope can help to cope with this disease. In addition, we discuss false hope. We also briefly touch on a few of the new therapies currently under development. PMID: 26638916 [PubMed - in process] from #PubMed... περισσότερα »
S-equol, a Secondary Metabolite of Natural Anticancer Isoflavone Daidzein, Inhibits Prostate Cancer Growth In Vitro and In Vivo, Though Activating the Akt/FOXO3a Pathway.
*S-equol, a Secondary Metabolite of Natural Anticancer Isoflavone Daidzein, Inhibits Prostate Cancer Growth In Vitro and In Vivo, Though Activating the Akt/FOXO3a Pathway.* Curr Cancer Drug Targets. 2015 Dec 6; Authors: Lu Z, Zhou R, Kong Y, Wang J, Xia W, Guo J, Liu J, Sun H, Liu K, Yang J, Mi M, Xu H Abstract Forkhead box O3 (FOXO3a) is a transcription factor with tumor suppressor functions that plays an important role in prostate cancer. Daidzein, one of the soy isoflavones present in soy-based foods, has been shown to exert anti-tumor effects in vitro and in vivo. We herein ... περισσότερα »
Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer.
*Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer.* Curr Cancer Drug Targets. 2015 Dec 6; Authors: Hu XQ, Sun Y, Lau E, Zhao M, Su SB Abstract The complex pathology of cancer development requires correspondingly complex treatments. The traditional application of individual single-target drugs fails to sufficiently treat cancer with durable therapeutic effects and tolerable adverse events. Therefore, synergistic combinations of drugs represent a promising way to enhance efficacy, overcome toxicity and optimize safety. Chinese Herbal Medi... περισσότερα »
Epi-drugs and Epi-miRs: Moving beyond current cancer therapies.
*Epi-drugs and Epi-miRs: Moving beyond current cancer therapies.* Curr Cancer Drug Targets. 2015 Dec 6; Authors: Salarini R, Sahebkar A, Mirzaei HR, Jaafari MR, Riahi MM, Hadjati J, Asrami MO, Fdaee S, Salehi R, Mirzaei H Abstract Epigenetic modifications determine phenotypic characteristics in a reversible, stable and genotype-independent manner; Epigenetic modifications mainly encompass CpG island methylation and histone modifications, both being important in the pathogenesis of malignancies. The reversibility of epigenetic phenomenon provides a suitable therapeutic option tha...περισσότερα »
ΠΡΟΓΡΑΜΜΑ ΕΚΠΑΙΔΕΥΣΗΣ ΑΣΘΕΝΩΝ ΜΕ ΣΠΑΝΙΕΣ ΠΑΘΗΣΕΙΣ
Αγαπητοί μας, Η *Πανελλήνια Ένωση Σπανίων Παθήσεων* διοργανώνει *πρόγραμμα σεμιναρίων για την εκπαίδευση ασθενών με Σπάνιες Παθήσεις*, τα οποία θα πραγματοποιηθούν εντός του έτους 2016. Συνημμένα βρείτε την *αφίσα* στην οποία αναφέρονται αναλυτικά τα θέματα των εν λόγω σεμιναρίων. Pespa 19x26cm-outline Η παρουσίαση του προγράμματος αυτού θα πραγματοποιηθεί την *Πέμπτη 17 Δεκεμβρίου 2015* και ώρες *17:30-19:30*, στο *Πνευματικό Κέντρο του Δήμου Αθηναίων*. Στο δεύτερο συνημμένο αρχείο θα βρείτε την *πρόσκληση*, στην οποία φαίνεται το πρόγραμμα της παρουσίασης αυτής, καθώς και οι ... περισσότερα »
Bilaterally enlarged parotids and sicca symptoms as a presentation of sarcoidosis: Pivotal role of aspiration cytology in diagnosis
*Tanya Sharma, Deepti Joshi, Alkesh Khurana, Vikas Gupta, Neelkamal Kapoor* Journal of Cytology 2015 32(4):281-283 Sarcoidosis is a chronic multisystem inflammatory disease of unknown etiology characterized by widespread noncaseating granulomas in various organs. The diagnosis of sarcoidosis is based on cytological, clinicolaboratory, and radiological findings, and requires careful exclusion of other granulomatous diseases especially tuberculosis. Involvement of parotid glands is uncommon. Presentation of sarcoidosis with sicca symptoms that include dryness of eyes and mouth is an e...περισσότερα »
Conjunctival impression cytology versus routine tear function tests for dry eye evaluation in contact lens wearers
*Prachi Kumar, Rahul Bhargava, Yogesh C Arora, Sidharth Kaushal, Manjushri Kumar* Journal of Cytology 2015 32(4):261-267 Aims: Prolonged contact lens wear is often accompanied by dryness of the eyes. The aim of this study was to compare conjunctival impression cytology (CIC) and tear film tests such as tear film break up time (TBUT) and Schirmer test for dry eye evaluation in contact lens wearers and measure their correlation with dry eye symptoms. Setting: A case control study was done at three referral eye centers. Materials and Methods: The eyes of 230 contact lens users were co... περισσότερα »
Lymphangioleiomyomatosis diagnosed by effusion cytology: A case report
*Glorimar Rivera, Tunc Gokaslan, Elizabeth M Kurian* Journal of Cytology 2015 32(4):287-289 Lymphangioleiomyomatosis (LAM) is a rare lung disease traditionally affecting women during their childbearing years. It can be sporadic or be associated with tuberous sclerosis syndrome. It is usually manifested in the lungs, kidneys, and/or lymphatic system. It consists of an overgrowth of abnormal smooth muscle-like cells, usually along the bronchovascular structures, resulting in the formation of cysts and the destruction of the lung parenchyma. We present the case of a 43-year-old woman w...περισσότερα »
"Sea anemone-like ciliated tumor cells" in a case of serous cystadenocarcinoma of the ovary
*Uma Handa, Shilpa Goyal, Harsh Mohan* Journal of Cytology 2015 32(4):268-269 from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1PUbP70 via IFTTT
Use of cell block preparation for improving adequacy of cytology smears
*Amit Kumar Chowhan, Rukmangadha Nandyala, Rashmi Patnayak, Asha Thotta* Journal of Cytology 2015 32(4):291-292 from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1N93Sa8 via IFTTT
Enhanced Systemic Bioavailability of Curcumin Through Transmucosal Administration of a Novel Microgranular Formulation.
Related Articles *Enhanced Systemic Bioavailability of Curcumin Through Transmucosal Administration of a Novel Microgranular Formulation.* Anticancer Res. 2015 Dec;35(12):6411-8 Authors: Latimer B, Ekshyyan O, Nathan N, Moore-Medlin T, Rong X, Ma X, Khandelwal A, Christy HT, Abreo F, McClure G, Vanchiere JA, Caldito G, Dugas T, McMartin K, Lian T, Mehta V, Nathan CA Abstract BACKGROUND/AIM: Curcumin is a promising nutraceutical for chemoprevention of head and neck squamous cell carcinoma (HNSCC). Capsular formulations of curcumin demonstrate low systemic bioavailability. We aimed... περισσότερα »
How I Do It: The Sphenoethmoidectomy.
Related Articles *How I Do It: The Sphenoethmoidectomy.* Am J Rhinol Allergy. 2015 Nov;29(6):457-8 Authors: Gudis DA, Karnezis TK, Soler ZM, Schlosser RJ Abstract BACKGROUND: Several techniques for performing the sphenoethmoidectomy have been described. We present a safe, effective, and efficient technique. OBJECTIVE: We present text, images, and video to demonstrate our preferred technique for performing a sphenoethmoidectomy. METHODS: A description of the technique without prospective or retrospective data, whereby a Kerrison rongeur and microdebrider were used to perform a tota... περισσότερα »
Endoscopic transantral and transnasal repair of orbital floor fracture with the ballooning technique, and classification and characterization of orbital floor fractures.
Related Articles *Endoscopic transantral and transnasal repair of orbital floor fracture with the ballooning technique, and classification and characterization of orbital floor fractures.* Am J Rhinol Allergy. 2015 Nov;29(6):445-8 Authors: Park IH, Lee HM, Yanagi K Abstract BACKGROUND: The level of difficulty during an endoscopic approach for an inferior orbital fracture depends on the fracture pattern and the presence of a ruptured membrane (orbital periosteum and sinus mucosa). The purpose of our study was to examine fracture patterns according to age group and to determine th... περισσότερα »
Inverted papilloma of the maxillary sinus: Surgical approach and long-term results.
Related Articles *Inverted papilloma of the maxillary sinus: Surgical approach and long-term results.* Am J Rhinol Allergy. 2015 Nov;29(6):441-4 Authors: Hong SL, Mun SJ, Cho KS, Roh HJ Abstract BACKGROUND: Inverted papillomas (IP) commonly develop in the maxillary sinus (MS). However, the MS is a complex structure, and all areas in the MS are not easily approachable. OBJECTIVE: This study reviewed our surgical outcome of patients with IPs that originated from the MS in long-term follow-up and suggests appropriate approaches according to the tumor origin. METHODS: Thirty-one pati...περισσότερα »
Contribution of synovial lining cells to synovial vascularization of the rat temporomandibular joint
Abstract The lining layer of the synovial membrane in the temporomandibular joint (TMJ) contains two types of lining cells: macrophage-like type A and fibroblast-like type B cells. The type B cells are particularly heterogeneous in their morphology and immunoreactivity, so that details of their functions remain unclear. Some of the type B cells exhibit certain resemblances in their ultrastructure to those of an activated capillary pericyte at the initial stage of the angiogenesis. The articular surface, composed of cartilage and the disc in the TMJ, has few vasculatures, whereas t... περισσότερα »
The Cancer Genome Atlas: More Than a Large Collection of Data
After collecting samples from more than 11,000 patients across 33 tumor types, and generating a vast, comprehensive data set to describe the molecular changes that occur in cancer, The Cancer Genome Atlas project is coming to a close. Tissue sample collection and data generation are completed. Eighteen integrative analyses of individual cancer types have been published and the analyses for another fifteen papers are underway. However, though TCGA will wrap up in 2016 with a concluding symposium, cancer genomics projects built upon the success of TCGA will continue to play a major ...περισσότερα »
Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo
Natural compounds have been demonstrated to lower breast cancer risk and sensitize tumor cells to anticancer therapies. Recently, we demonstrated that vernodalin (the active constituent of the medicinal herb Cent... from Cancer via ola Kala on Inoreader http://ift.tt/1ORffEh via IFTTT
Asymptomatic peritoneal carcinomatosis originating from benign cystic peritoneal mesothelioma
S Iacoponi, J Calleja, G Hernandez and R Sainz de la Cuesta from Cancer via ola Kala on Inoreader http://ift.tt/1R71a98 via IFTTT
Consecutive magnetic resonance imaging during brachytherapy for cervical carcinoma: predictive value of volume measurements with respect to persistent disease and prognosis
Abstract Background Cervical cancer is associated with a high yearly mortality. The presence of persistent disease after radiotherapy is a significant predictor of patient survival. The aim of our study was to assess if tumor volume regression measured with MR imaging at the time of brachytherapy can discriminate between patients who eventually will achieve a complete response to radiotherapy from those who will not. The second objective was to evaluate whether tumor volume regression predicts overall treatment failure. Methods MRI was evaluated quantitatively in 35 patients; by ... περισσότερα »
Viruses, Vol. 7, Pages 6412-6423: Molecular Epidemiology of Human Rhinoviruses and Enteroviruses Highlights Their Diversity in Sub-Saharan Africa
Human rhinoviruses (HRVs) and enteroviruses (HEVs) belong to the Enterovirus genus and are the most frequent cause of infection worldwide, but data on their molecular epidemiology in Africa are scarce. To understand HRV and HEV molecular epidemiology in this setting, we enrolled febrile pediatric patients participating in a large prospective cohort assessing the causes of fever in Tanzanian children. Naso/oropharyngeal swabs were systematically collected and tested by real-time RT-PCR for HRV and HEV. Viruses from positive samples were sequenced and phylogenetic analyses were then...περισσότερα »
Verbesserte Prognose für symptomfreie ältere Frauen mit einem durch Mammographie detektiertem Mammakarzinom?
from Pharmacology via ola Kala on Inoreader http://ift.tt/1jLf9Tn via IFTTT
Consecutive magnetic resonance imaging during brachytherapy for cervical carcinoma: predictive value of volume measurements with respect to persistent disease and prognosis
Cervical cancer is associated with a high yearly mortality. The presence of persistent disease after radiotherapy is a significant predictor of patient survival. from Cancer via ola Kala on Inoreader http://ift.tt/1m85VSU via IFTTT
Cancers, Vol. 7, Pages 2372-2385: Loss of E2F1 Extends Survival and Accelerates Oral Tumor Growth in HPV-Positive Mice
The Human Papillomavirus (HPV) is associated with several human cancers, including head and neck squamous cell carcinomas (HNSCCs). HPV expresses the viral oncogene E7 that binds to the retinoblastoma protein (RB1) in order to activate the E2F pathway. RB1 can mediate contradictory pathways—cell growth and cell death via E2F family members. Here, we assessed the extent to which E2F1 mediates lethality of HPV oncogenes. Ubiquitous expression of the HPV oncogenes E6 and E7 caused lethality in mice that was associated with focal necrosis in hepatocytes and pancreatic tissues. Further... περισσότερα »
MTUS1 and its targeting miRNAs in colorectal carcinoma: significant associations
Abstract Deregulated microRNA (miRNA) expression has been shown to be involved in the pathogenesis of several types of cancers including colorectal cancer (CRC). Thus, determining miRNA targets of genes that play critical role in the malignant transformation is very important. Here, expression levels of tumor suppressor microtubule-associated tumor suppressor 1 (*MTUS1)* and its regulatory miRNAs were reported. Predicted and validated targets of *MTUS1* gene was determined by a computational approach. Expressions of *MTUS1* and miRNAs were determined by using 96.96 Dynamic Array™ i...περισσότερα »
Down-regulation of SNX1 predicts poor prognosis and contributes to drug resistance in colorectal cancer
Abstract As a potential tumor suppressor, the detailed clinical application value of sorting nexin 1 (SNX1) has not been elucidated in colorectal cancer (CRC). The aim of the present study was to evaluate the expression of SNX1 in CRC tissues and to determine its correlation with clinicopathologic characteristics and its impact on patient's prognosis. We detected the expression of SNX1 mRNA in 72 CRC patients and SNX1 protein in 237 CRC patients by real-time polymerase chain reaction (RT-PCR) and immunohistochemical staining, respectively. Relationship between the expression of SN...περισσότερα »
Promoter-associated endogenous and exogenous small RNAs suppress human bladder cancer cell metastasis by activating p21 CIP1/WAF1 expression
Abstract Accumulating data suggest that micro RNAs (miRNAs) or double-stranded RNAs (dsRNAs) can activate gene expression by targeting promoters. The cyclin-dependent kinase inhibitor *p21* *CIP1*/*WAF1* (*p21*) has also been shown to suppress epithelial-mesenchymal transition (EMT) which plays a crucial role in the early stage of tumor metastases and invasiveness. In a previous study, we have reported that miR-370-5p is low-expressed in bladder cancer (BCa) tissues and cell lines. Here, we identified that miR-370-5p and sequence homology dsRNA (dsP21-555) fully complementary to p...περισσότερα »
PIN1 genetic polymorphisms and the susceptibility of HBV-related hepatocellular carcinoma in a Guangxi population
Abstract Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (PIN1) plays a critical role in different signaling pathways, cell cycle progression and proliferation, and gene expression, and it has been found to overexpress in many tumor tissues. Recently, researchers have found that PIN1 gene polymorphisms may alter the function of protein and be associated with the risk of cancer. The present study analyzed three common polymorphisms in promoter regions (rs2233678 and rs2233679) and in exon2 (rs2233682) of the PIN1 gene in 254 patients with hepatitis B virus (HBV)-related hepa...περισσότερα »
Elevated serum soluble CD14 levels in chronic HBV infection are significantly associated with HBV-related hepatocellular carcinoma
Abstract Hepatitis B virus (HBV) infection is a major cause of chronic liver diseases including hepatocellular carcinoma (HCC). CD14 and its soluble form sCD14 play important roles in immunity and are involved in the translocation of bacteria and their products which is related to the pathogenesis in chronic HBV infection. This study investigated serum sCD14 levels in HBV chronically infected patients with various clinical diseases. Serum sCD14 levels in HBV patients were significantly elevated compared with those of healthy controls. HCC patients had significantly highest levels ... περισσότερα »
Blocking autophagy enhanced leukemia cell death induced by recombinant human arginase
Abstract Recombinant human arginase (rhArg) is an arginine-degrading enzyme that has been evaluated as effective therapeutics for varieties of malignant tumors and is in clinical trials for hepatocellular carcinoma (HCC) treatment nowadays. Our previous studies have reported that rhArg could induce autophagy and apoptosis in lymphoma cells and inhibiting autophagy could enhance the efficacy of rhArg on lymphoma. However, whether rhArg could induce autophagy and what roles autophagy plays in leukemia cells are unclear. In this study, we demonstrated that rhArg treatment could lead t...περισσότερα »
Acetazolamide-Induced Nephrolithiasis in Idiopathic Intracranial Hypertension Patients.
Background: Idiopathic intracranial hypertension (IIH) is a neurological disorder characterized by elevated intracranial pressure of unknown cause. Acetazolamide is widely used as the initial treatment option; however, previously published evidence suggests that this drug may also increase the risk of nephrolithiasis. The purpose of this study was to examine daily acetazolamide use and its relationship to nephrolithiasis and compare clinical presentation of IIH between those with and without nephrolithiasis. Methods: We conducted a case-control study using patient data collected by ... περισσότερα »
Safety and Tolerability of Acetazolamide in the Idiopathic Intracranial Hypertension Treatment Trial.
Objective: To examine the tolerability and adverse events reported in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT). Methods: Randomized, double-masked, placebo-controlled clinical trial. Trial participants (n = 165) with mild visual loss concurrently receiving low-sodium weight-reduction diet plus the maximally tolerated dosage of acetazolamide (up to 4 g/d) or placebo for 6 months. Main outcomes measures: adverse events (AEs), assessment of clinical and laboratory findings at study visits. Results: Thirty-eight of 86 participants randomized to the acetazolamide ... περισσότερα »
A 29-Year-Old Nurse With Fatigue, Anxiety, and Depression.
No abstract available from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1TxQEW8 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1M0uTIT via IFTTT
The Optic Canal Size Is Associated With the Severity of Papilledema and Poor Visual Function in Idiopathic Intracranial Hypertension.
Background: To determine whether the size of the bony optic canal is associated with the severity of papilledema and poor visual function in idiopathic intracranial hypertension (IIH). Methods: We performed a retrospective review of definite patients with IIH with requisite brain magnetic resonance imaging allowing for optic canal measurement. Clinical characteristics and automated (Humphrey) visual field results were reviewed; papilledema was graded according to the modified Frisen scale. Cross-sectional area of the optic canals was measured independently by 2 readers and averaged ... περισσότερα »
Optic Nerve Sheath Melanoma Presenting as a Central Retinal Vein Occlusion.
A 64-year-old woman, with a history of diabetes and melanoma, developed a central retinal vein occlusion (CRVO) in her left eye. On exam, she had severe disc edema with retinal nerve fiber layer thickening, and anterior deformation of the peripapillary retinal pigment epithelium (RPE)/Bruch membrane layer (ppRPE/BM) toward the vitreous on spectral domain optical coherence tomography (SD-OCT) suggesting an optic nerve sheath (ONS) meningioma. Magnetic resonance imaging findings and ONS biopsy later confirmed a metastatic melanoma. This case demonstrates that the shape of the RPE/BM o... περισσότερα »
Suprasellar Primitive Neuroectodermal Tumor in an Adult.
Primitive neuroectodermal tumors (PNET) of the central nervous system (CNS) are a heterogeneous group of embryonal malignancies that are composed of undifferentiated or poorly differentiated neuroepithelial cells. Supratentorial PNET is the second most common CNS embryonal malignancy in children, but it is rare in adults. We report the case of a 31-year-old woman with bilateral vision loss and a bitemporal hemianopia. Neuroimaging revealed a suprasellar mass, and pathology was consistent with PNET. After surgical debulking of the tumor followed by radiation therapy and chemotherapy,...περισσότερα »
Enhanced Optical Transmission through MacEtch-Fabricated Buried Metal Gratings
[image: Thumbnail image of graphical abstract] *Metallic films with subwavelength apertures*, integrated into a semiconductor by metal-assisted chemical etch (MacEtch), demonstrate enhanced transmission when compared to bare semiconductor surfaces. The resulting "buried" metallic structures are characterized spectroscopically and modeled using rigorous coupled wave analysis. These composite materials offer potential integration with optoelectronic devices, for simultaneous near-uniform electrical contact and strong optical coupling to free space. from #MedicinebyAlexandrosSfakianak... περισσότερα »
The imbalance of masticatory muscle activity affects the asymmetric growth of condylar cartilage and subchondral bone in rats
Publication date: March 2016 *Source:*Archives of Oral Biology, Volume 63 Author(s): Mutsumi Miyazaki, Ikuo Yonemitsu, Maki Takei, Ikuko Kure-Hattori, Takashi Ono ObjectiveTo examine the effects of imbalance of masticatory muscle activity of the rat mandible on the condylar cartilage and subchondral bone during the growth period.DesignForty 5-week-old male Wistar rats were randomly divided into experimental (n=20) and control (n=20) groups. In the experimental group, the left masseter muscles were resected. The rats were sacrificed at 7 or 9 weeks of age in both groups. Microcompute...περισσότερα »
The imbalance of masticatory muscle activity affects the asymmetric growth of condylar cartilage and subchondral bone in rats
Publication date: March 2016 *Source:*Archives of Oral Biology, Volume 63 Author(s): Mutsumi Miyazaki, Ikuo Yonemitsu, Maki Takei, Ikuko Kure-Hattori, Takashi Ono ObjectiveTo examine the effects of imbalance of masticatory muscle activity of the rat mandible on the condylar cartilage and subchondral bone during the growth period.DesignForty 5-week-old male Wistar rats were randomly divided into experimental (n=20) and control (n=20) groups. In the experimental group, the left masseter muscles were resected. The rats were sacrificed at 7 or 9 weeks of age in both groups. Microcompute...περισσότερα »
Pallet to Palate: Extending Shelf Life and Safety in Microgreens with PCR
[image: single_lettuce_plant_grown_using_hydropo] For producers of perishables with limited shelf life, shaving even a few days from on-site food safety procedures and getting the product into the hands of customers faster is a valuable goal. And that's exactly what Florida Urban Organics has done by implementing real-time PCR into their pathogen screening workflow. Florida Urban Organics is an innovative, certified Read the rest of this article The post Pallet to Palate: Extending Shelf Life and Safety in Microgreens with PCR appeared first on Accelerating Science. from #Medici... περισσότερα »
Methylator phenotype in colorectal cancer: a prognostic factor or not?
Publication date: Available online 7 December 2015 *Source:*Critical Reviews in Oncology/Hematology Author(s): C. Gallois, P. Laurent-Puig, J. Taieb Colorectal cancer (CRC) is due to different types of genetic alterations that are translated into different phenotypes. Among them, CpG island methylator phenotype (CIMP+) is the most recently involved in carcinogenesis of some CRC. The malignant transformation is in this case mainly due to the transcriptional inactivation of tumor suppressor genes. CIMP+ are reported to be more frequently found in the elderly and in women. The tumors a...περισσότερα »
RNAseq analysis for the diagnosis of muscular dystrophy
Abstract The precise genetic cause remains elusive in nearly 50% of patients with presumed neurogenetic disease, representing a significant barrier for clinical care. This is despite significant advances in clinical genetic diagnostics, including the application of whole-exome sequencing and next-generation sequencing-based gene panels. In this study, we identify a deep intronic mutation in the *DMD* gene in a patient with muscular dystrophy using both conventional and RNAseq-based transcriptome analyses. The implications of our data are that noncoding mutations likely comprise an ...περισσότερα »
OtoRhinoLaryngology & Medicine,New Articles,December 8th,2015
The treatment modalities and pain management of temporomandibular disorders Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα Reported concepts for the treatment modalities and pain management of temporomandibular disorders: Background: Pain related to temporomandibular disorders (TMD) is a common problem in modern societies. The aim of the article is to present the concepts of TMD pain clinical management. Methods: A survey was performed using the PubMed, SCOPUS and CINAHL databases for documents published between 1994 and 2014. The fo... περισσότερα »
OtoRhinoLaryngology & Medicine,New Articles,December 8th,2015,a
The treatment modalities and pain management of temporomandibular disorders Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα Reported concepts for the treatment modalities and pain management of temporomandibular disorders: Background: Pain related to temporomandibular disorders (TMD) is a common problem in modern societies. The aim of the article is to present the concepts of TMD pain clinical management. Methods: A survey was performed using the PubMed, SCOPUS and CINAHL databases for documents published between 1994 and 2014. The f... περισσότερα »
OtoRhinoLaryngology & Medicine,New Articles,December 8th,2015
The treatment modalities and pain management of temporomandibular disorders Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα Reported concepts for the treatment modalities and pain management of temporomandibular disorders: Background: Pain related to temporomandibular disorders (TMD) is a common problem in modern societies. The aim of the article is to present the concepts of TMD pain clinical management. Methods: A survey was performed using the PubMed, SCOPUS and CINAHL databases for documents published between 1994 and 2014. The fo... περισσότερα »
OtoRhinoLaryngology & Medicine,New Articles,December 8th,2015
British Journal of Oral and Maxillofacial Surgery Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 20 δευτερόλεπτα Association between p53 status, human papillomavirus infection, and overall survival in advanced oral cancer after resection and combination systemic treatment Publication date: Available online 6 December 2015 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Tommaso Cutilli, Pietro Leocata, Vincenza Dolo, Emma Altobelli Our previous study on 75 cases of advanced oral squamous cell carcinomas (SCC) treated by neoadjuvant chemot... περισσότερα »
The treatment modalities and pain management of temporomandibular disorders
Reported concepts for the treatment modalities and pain management of temporomandibular disorders: Background: Pain related to temporomandibular disorders (TMD) is a common problem in modern societies. The aim of the article is to present the concepts of TMD pain clinical management. Methods: A survey was performed using the PubMed, SCOPUS and CINAHL databases for documents published between 1994 and 2014. The following search keywords were selected using MeSH terms of the National Library of Medicine in combination: TMD pain, TMD, TMJ, TMJ disorders, occlusal splint, TMD physiothera... περισσότερα »
Horner’s syndrome and unilateral facial paresis
in a goat: a case report: AbstractA 4-year-old, female Pakistani goat was referred to the veterinary teaching hospital for first pregnancy check up. At the time of presentation, the case was apparently healthy. Incidentally, the clinicians noticed the abnormality in the left eye. A precise ophthalmic examination revealed ptosis, entropion, nictitating membrane prolapse, enophthalmos, and miosis in the left eye, whereas the eyelids and pupil were normal on the right side. The left eye lacked palpebral reflex, and the menace response seemed to be decreased. Pupillary light reflex was... περισσότερα »
Whole-mount pathology of breast lumpectomy specimens improves detection of tumour margins and focality
[image: cover.gif?v=1&s=3694dc29810624c6fbc8ceb7] *Abstract* Aims Technical limitations in conventional pathologic evaluation of breast lumpectomy specimens may reduce diagnostic accuracy in assessment of margin and focality. A novel technique based on whole-mount serial sections enhances sampling while preserving specimen conformation and orientation. We compare assessment of focality and margin status using whole-mount serial sections versus simulated conventional sections in lumpectomies. Methods and Results Two pathologists interpreted whole-mount serial sections and simulated ... περισσότερα »
SATB2 expression is sensitive but may not be specific for osteosarcoma compared to other high-grade primary bone sarcomas
Abstract Aims Diagnosis of osteosarcoma, while important for eligibility in clinical trials and proper therapy, may be challenging when no bone or osteoid matrix is identified on biopsy. Therefore, other adjunct tests have been sought to help confirm the diagnosis. SATB2 has been shown as a reliable marker of osteoblastic differentiation. The aim of this study was to examine SATB2 expression in osteosarcomas and other primary bone sarcomas, to evaluate its diagnostic utility in discriminating osteogenic versus non-osteogenic sarcomas. Methods and Results Forty-eight pre-treated ost... περισσότερα »
Osteosarcoma compared to other high-grade primary bone sarcomas
SATB2 expression is sensitive but may not be specific for osteosarcoma compared to other high-grade primary bone sarcomas: Abstract Aims Diagnosis of osteosarcoma, while important for eligibility in clinical trials and proper therapy, may be challenging when no bone or osteoid matrix is identified on biopsy. Therefore, other adjunct tests have been sought to help confirm the diagnosis. SATB2 has been shown as a reliable marker of osteoblastic differentiation. The aim of this study was to examine SATB2 expression in osteosarcomas and other primary bone sarcomas, to evaluate its diagn...περισσότερα »
Use of Dexmedetomidine for Prophylactic Analgesia and Sedation in Patients With Delayed Extubation After Craniotomy: A Randomized Controlled Trial.
Use of Dexmedetomidine for Prophylactic Analgesia and Sedation in Patients With Delayed Extubation After Craniotomy: A Randomized Controlled Trial.: Background: We conducted a randomized trial to evaluate the efficacy and safety of dexmedetomidine for prophylactic analgesia and sedation in patients with delayed extubation after craniotomy. Methods: From June 2012 to July 2014, 150 patients with delayed extubation after craniotomy were randomized 1:1 and were assigned to the dexmedetomidine group that received a continuous infusion of 0.6 [mu]g/kg/h (10 [mu]g/mL) or the control group ... περισσότερα »
HLA and Risk of Diffuse Large B-cell Lymphoma After Solid Organ Transplantation.
HLA and Risk of Diffuse Large B-cell Lymphoma After Solid Organ Transplantation.: Background: Solid organ transplant recipients have heightened risk for diffuse large B-cell lymphoma (DLBCL). The role of donor-recipient HLA mismatch and recipient HLA type on DLBCL risk are not well established. Methods: We examined 172 231 kidney, heart, pancreas, and lung recipients transplanted in the United States between 1987 and 2010, including 902 with DLBCL. Incidence rate ratios (IRRs) were calculated using Poisson regression for DLBCL risk in relation to HLA mismatch, types, and zygosity, a...περισσότερα »
Giant and aggressive earlobe keloids
Unusually giant and aggressive earlobe keloids – Two clinical reports via ScienceDirect Publication: Egyptian Journal of Ear, Nose, Throat and Allied Sciences Figures and tables 1. [image: Right side earlobe showing a giant keloid with an ulcer over the surface.] 2. [image: Microphotograph showing keloidal collagen with abundant fibroblasts.] 3. [image: Left side earlobe showing a gaint and lobulated keloid.] 4. [image: Microphotograph of keloid showing abnormally large dense, broad, glassy, ...] *Source:*Egyptian Journal of Ear, Nose, Throat and Allied Scie... περισσότερα »
Congenital mandibular epulis
– A rare oral lesion in a newborn via ScienceDirect Publication: Egyptian Journal of Ear, Nose, Throat and Allied Sciences Figures and tables 1. [image: Oral mass seen upon delivering via caesarean section.] 2. [image: CT scan view of the lesion.] 3. [image: Image showing the location of tumour.] 4. [image: Image shows excision done using monopolar diathermy.] *Source:*Egyptian Journal of Ear, Nose, Throat and Allied Sciences, Volume 16, Issue 3 Author(s): Nurhani Yasmin Abdul Rahman, Hashimah Ismail, Irfan Mohamad, Suhaimi Yusof, Hazama Mohamad IntroductionCongenita... περισσότερα »
Randomized crossover sham-controlled clinical trial of targeted low-frequency transcranial magnetic stimulation comparing a figure-8 and a round coil to treat refractory neocortical epilepsy
Summary Objective Determine the efficacy and side effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) to treat refractory neocortical epilepsy and study differences in effect between a figure-8 and round coil type. Methods This single-center randomized sham-controlled crossover trial (NCT01745952 on ClinicalTrials.gov) included 11 patients with well-defined focal epilepsy. rTMS (0.5 Hz) was targeted to the focus during three treatment conditions consisting of 1,500 stimulations/day for 10 weekdays at 90% of resting motor threshold (rMT) followed by a 10-...περισσότερα »
Contribution of synovial lining cells to synovial vascularization of the rat temporomandibular joint
Abstract The lining layer of the synovial membrane in the temporomandibular joint (TMJ) contains two types of lining cells: macrophage-like type A and fibroblast-like type B cells. The type B cells are particularly heterogeneous in their morphology and immunoreactivity, so that details of their functions remain unclear. Some of the type B cells exhibit certain resemblances in their ultrastructure to those of an activated capillary pericyte at the initial stage of the angiogenesis. The articular surface, composed of cartilage and the disc in the TMJ, has few vasculatures, whereas t... περισσότερα »
Quantitative comparison of cerebral artery development in metatherians and monotremes with non-human eutherians
Abstract A quantitative comparison of the internal diameters of cerebral feeder arteries (internal carotid and vertebral) and the aorta in developing non-human eutherians, metatherians and monotremes has been made, with the aim of determining if there are differences in cerebral arterial flow between the three infraclasses of mammals such as might reflect differences in metabolism of the developing brain. There were no significant differences between eutherians and metatherians in the internal radius of the aorta or the thickness of the aortic wall, but aortic internal radius was ... περισσότερα »
Mathematics, Vol. 3, Pages 1222-1240: Robust Finite-Time Anti-Synchronization of Chaotic Systems with Different Dimensions
In this paper, we demonstrate that anti-synchronization (AS) phenomena of chaotic systems with different dimensions can coexist in the finite-time with under the effect of both unknown model uncertainty and external disturbance. Based on the finite-time stability theory and using the master-slave system AS scheme, a generalized approach for the finite-time AS is proposed that guarantee the global stability of the closed-loop for reduced order and increased order AS in the finite time. Numerical simulation results further verify the robustness and effectiveness of the proposed fini... περισσότερα »
Toxins, Vol. 7, Pages 5320-5321: Preface Biological Toxins—Ancient Molecules Posing a Current Threat
n/a from #Medicine via ola Kala on Inoreader http://ift.tt/1HS6SbY via IFTTT
Chronic Myelogenous Leukemia Relapse Presenting With CNS Blast Crisis and Bilateral Optic Nerve Infiltration.
Bilateral, simultaneous optic nerve sheath infiltration as a manifestation of leukemia relapse is very rare. A 45-year-old woman with chronic myelogenous leukemia was successfully treated to cytogenetic bone marrow remission 1 year previously and maintained on imatinib. She developed total bilateral blindness with marked, bilateral optic disc edema and evidence of bilateral optic nerve infiltration on magnetic resonance imaging. Cerebrospinal fluid cytology confirmed central nervous system (CNS) blast crisis. She recovered visual acuity of 20/20 in the right eye, and 20/25 in the le... περισσότερα »
Factors Affecting Visual Field Outcomes in the Idiopathic Intracranial Hypertension Treatment Trial.
Background: To determine the prevalence of visual field (VF) performance failures (PF) and treatment failures (TFs), and identify factors associated with PFs in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT). Methods: A total of 165 participants from 38 sites with idiopathic intracranial hypertension (IIH) and mild visual loss were randomized to either acetazolamide-plus diet or placebo-plus diet. The IIHTT Visual Field Reading Center evaluated 2950 Swedish Interactive Threshold Algorithm Standard 24-2 VFs from the enrolled participants. A TF was defined when the p... περισσότερα »
Acetazolamide-Induced Nephrolithiasis in Idiopathic Intracranial Hypertension Patients.
Background: Idiopathic intracranial hypertension (IIH) is a neurological disorder characterized by elevated intracranial pressure of unknown cause. Acetazolamide is widely used as the initial treatment option; however, previously published evidence suggests that this drug may also increase the risk of nephrolithiasis. The purpose of this study was to examine daily acetazolamide use and its relationship to nephrolithiasis and compare clinical presentation of IIH between those with and without nephrolithiasis. Methods: We conducted a case-control study using patient data collected by ... περισσότερα »
Safety and Tolerability of Acetazolamide in the Idiopathic Intracranial Hypertension Treatment Trial.
Objective: To examine the tolerability and adverse events reported in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT). Methods: Randomized, double-masked, placebo-controlled clinical trial. Trial participants (n = 165) with mild visual loss concurrently receiving low-sodium weight-reduction diet plus the maximally tolerated dosage of acetazolamide (up to 4 g/d) or placebo for 6 months. Main outcomes measures: adverse events (AEs), assessment of clinical and laboratory findings at study visits. Results: Thirty-eight of 86 participants randomized to the acetazolamide ... περισσότερα »
A 29-Year-Old Nurse With Fatigue, Anxiety, and Depression.
No abstract available from Neurology via xlomafota13 on Inoreader http://ift.tt/1TxQEW8 via IFTTT
The Optic Canal Size Is Associated With the Severity of Papilledema and Poor Visual Function in Idiopathic Intracranial Hypertension.
Background: To determine whether the size of the bony optic canal is associated with the severity of papilledema and poor visual function in idiopathic intracranial hypertension (IIH). Methods: We performed a retrospective review of definite patients with IIH with requisite brain magnetic resonance imaging allowing for optic canal measurement. Clinical characteristics and automated (Humphrey) visual field results were reviewed; papilledema was graded according to the modified Frisen scale. Cross-sectional area of the optic canals was measured independently by 2 readers and averaged ... περισσότερα »
Optic Nerve Sheath Melanoma Presenting as a Central Retinal Vein Occlusion.
A 64-year-old woman, with a history of diabetes and melanoma, developed a central retinal vein occlusion (CRVO) in her left eye. On exam, she had severe disc edema with retinal nerve fiber layer thickening, and anterior deformation of the peripapillary retinal pigment epithelium (RPE)/Bruch membrane layer (ppRPE/BM) toward the vitreous on spectral domain optical coherence tomography (SD-OCT) suggesting an optic nerve sheath (ONS) meningioma. Magnetic resonance imaging findings and ONS biopsy later confirmed a metastatic melanoma. This case demonstrates that the shape of the RPE/BM o... περισσότερα »
Suprasellar Primitive Neuroectodermal Tumor in an Adult.
Primitive neuroectodermal tumors (PNET) of the central nervous system (CNS) are a heterogeneous group of embryonal malignancies that are composed of undifferentiated or poorly differentiated neuroepithelial cells. Supratentorial PNET is the second most common CNS embryonal malignancy in children, but it is rare in adults. We report the case of a 31-year-old woman with bilateral vision loss and a bitemporal hemianopia. Neuroimaging revealed a suprasellar mass, and pathology was consistent with PNET. After surgical debulking of the tumor followed by radiation therapy and chemotherapy,...περισσότερα »
The imbalance of masticatory muscle activity affects the asymmetric growth of condylar cartilage and subchondral bone in rats
Publication date: March 2016 *Source:*Archives of Oral Biology, Volume 63 Author(s): Mutsumi Miyazaki, Ikuo Yonemitsu, Maki Takei, Ikuko Kure-Hattori, Takashi Ono ObjectiveTo examine the effects of imbalance of masticatory muscle activity of the rat mandible on the condylar cartilage and subchondral bone during the growth period.DesignForty 5-week-old male Wistar rats were randomly divided into experimental (n=20) and control (n=20) groups. In the experimental group, the left masseter muscles were resected. The rats were sacrificed at 7 or 9 weeks of age in both groups. Microcompute...περισσότερα »
The Journal of Clinical Endocrinology & Metabolism Vol. 100, No. 12, December 1, 2015 is now available online
Table of Contents Alert The Journal of Clinical Endocrinology & Metabolism- *Volume*: 100, *Number*: 12 (December 2015) ------------------------------ The above issue is now available online at: http://press.endocrine.org/toc/jcem/100/12?ai=se&ui=26u7&af=H ------------------------------ [image: Journal of Clinical Endocrinology & Metabolism masthead] ------------------------------ ------------------------------ The Journal of Clinical Endocrinology & Metabolism Home Page Current Issue Past Issues ------------------------------ ------------------------------ --------------------------... περισσότερα »
Whole-mount pathology of breast lumpectomy specimens improves detection of tumour margins and focality
[image: cover.gif?v=1&s=3694dc29810624c6fbc8ceb7] *Abstract* Aims Technical limitations in conventional pathologic evaluation of breast lumpectomy specimens may reduce diagnostic accuracy in assessment of margin and focality. A novel technique based on whole-mount serial sections enhances sampling while preserving specimen conformation and orientation. We compare assessment of focality and margin status using whole-mount serial sections versus simulated conventional sections in lumpectomies. Methods and Results Two pathologists interpreted whole-mount serial sections and simulat... περισσότερα »
SATB2 expression is sensitive but may not be specific for osteosarcoma compared to other high-grade primary bone sarcomas
Abstract Aims Diagnosis of osteosarcoma, while important for eligibility in clinical trials and proper therapy, may be challenging when no bone or osteoid matrix is identified on biopsy. Therefore, other adjunct tests have been sought to help confirm the diagnosis. SATB2 has been shown as a reliable marker of osteoblastic differentiation. The aim of this study was to examine SATB2 expression in osteosarcomas and other primary bone sarcomas, to evaluate its diagnostic utility in discriminating osteogenic versus non-osteogenic sarcomas. Methods and Results Forty-eight pre-treated ... περισσότερα »
Methylator phenotype in colorectal cancer: a prognostic factor or not?
Publication date: Available online 7 December 2015 *Source:*Critical Reviews in Oncology/Hematology Author(s): C. Gallois, P. Laurent-Puig, J. Taieb Colorectal cancer (CRC) is due to different types of genetic alterations that are translated into different phenotypes. Among them, CpG island methylator phenotype (CIMP+) is the most recently involved in carcinogenesis of some CRC. The malignant transformation is in this case mainly due to the transcriptional inactivation of tumor suppressor genes. CIMP+ are reported to be more frequently found in the elderly and in women. The tumors a...περισσότερα »
RNAseq analysis for the diagnosis of muscular dystrophy
Abstract The precise genetic cause remains elusive in nearly 50% of patients with presumed neurogenetic disease, representing a significant barrier for clinical care. This is despite significant advances in clinical genetic diagnostics, including the application of whole-exome sequencing and next-generation sequencing-based gene panels. In this study, we identify a deep intronic mutation in the *DMD* gene in a patient with muscular dystrophy using both conventional and RNAseq-based transcriptome analyses. The implications of our data are that noncoding mutations likely comprise an...περισσότερα »
Television distribution: economic dimensions, emerging policies
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Acceptable range for structural fire resistance in performance based design
Structural fire safety engineering is increasingly moving away from prescriptive design rules to what is generally referred to as Performance Based Design (PBD) in which the structure or structural components are designed to satisfy performance requirements. By taking into account the specific characteristics of the structure, a PBD can allow for more directed investments in safety, resulting in structures which are both more economical and safer compared to designs according to traditional prescriptive rules. Although stakeholders mostly agree that the structure should have a goo... περισσότερα »
Analyzing the Divide between FPGA Academic and Commercial Results
The pinnacle of success for academic work is often achieved by having impact on commercial products. In order to have a successful transfer bridge, academic evaluation flows need to provide representative results of similar quality to commercial flows. A majority of publications in FPGA research use the same set of known academic CAD tools and benchmarks to evaluate new architecture and tool ideas. However, it is not clear whether the claims in academic publications based on these tools and benchmarks translate to real benefits in commercial products. In this work we compare the l... περισσότερα »
Effects of imidacloprid in combination with λ-cyhalothrin on the model pollinator Bombus terrestris at different levels of complexity
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Design, construction and testing of a COC 3D flow-over flow-through bioreactor for hepatic cell culture
In this poster, we present the joint development efforts for a 3D microfluidic bioreactor for hepatic cell cultures. Cyclic Olefin Copolymer (COC) was selected for constructing the bioreactor, since the material has good chemical resistance, low adsorption and good optical properties, including low auto-fluorescence. A downside of COC is that it is much more difficult to structure than more traditional microfluidic materials, such as PDMS, PMMA, … Two parallel approaches were developed for structuring the COC. In a first approach, mechanical micro-milling of the channels allows fo... περισσότερα »
Legal aspects of end-of-life decisions of minors: euthanasia as case
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Acetazolamide-Induced Nephrolithiasis in Idiopathic Intracranial Hypertension Patients.
Background: Idiopathic intracranial hypertension (IIH) is a neurological disorder characterized by elevated intracranial pressure of unknown cause. Acetazolamide is widely used as the initial treatment option; however, previously published evidence suggests that this drug may also increase the risk of nephrolithiasis. The purpose of this study was to examine daily acetazolamide use and its relationship to nephrolithiasis and compare clinical presentation of IIH between those with and without nephrolithiasis. Methods: We conducted a case-control study using patient data collected by ... περισσότερα »
Safety and Tolerability of Acetazolamide in the Idiopathic Intracranial Hypertension Treatment Trial.
Objective: To examine the tolerability and adverse events reported in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT). Methods: Randomized, double-masked, placebo-controlled clinical trial. Trial participants (n = 165) with mild visual loss concurrently receiving low-sodium weight-reduction diet plus the maximally tolerated dosage of acetazolamide (up to 4 g/d) or placebo for 6 months. Main outcomes measures: adverse events (AEs), assessment of clinical and laboratory findings at study visits. Results: Thirty-eight of 86 participants randomized to the acetazolamide ... περισσότερα »
A 29-Year-Old Nurse With Fatigue, Anxiety, and Depression.
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The Optic Canal Size Is Associated With the Severity of Papilledema and Poor Visual Function in Idiopathic Intracranial Hypertension.
Background: To determine whether the size of the bony optic canal is associated with the severity of papilledema and poor visual function in idiopathic intracranial hypertension (IIH). Methods: We performed a retrospective review of definite patients with IIH with requisite brain magnetic resonance imaging allowing for optic canal measurement. Clinical characteristics and automated (Humphrey) visual field results were reviewed; papilledema was graded according to the modified Frisen scale. Cross-sectional area of the optic canals was measured independently by 2 readers and averaged ... περισσότερα »
Optic Nerve Sheath Melanoma Presenting as a Central Retinal Vein Occlusion.
A 64-year-old woman, with a history of diabetes and melanoma, developed a central retinal vein occlusion (CRVO) in her left eye. On exam, she had severe disc edema with retinal nerve fiber layer thickening, and anterior deformation of the peripapillary retinal pigment epithelium (RPE)/Bruch membrane layer (ppRPE/BM) toward the vitreous on spectral domain optical coherence tomography (SD-OCT) suggesting an optic nerve sheath (ONS) meningioma. Magnetic resonance imaging findings and ONS biopsy later confirmed a metastatic melanoma. This case demonstrates that the shape of the RPE/BM o... περισσότερα »
Suprasellar Primitive Neuroectodermal Tumor in an Adult.
Primitive neuroectodermal tumors (PNET) of the central nervous system (CNS) are a heterogeneous group of embryonal malignancies that are composed of undifferentiated or poorly differentiated neuroepithelial cells. Supratentorial PNET is the second most common CNS embryonal malignancy in children, but it is rare in adults. We report the case of a 31-year-old woman with bilateral vision loss and a bitemporal hemianopia. Neuroimaging revealed a suprasellar mass, and pathology was consistent with PNET. After surgical debulking of the tumor followed by radiation therapy and chemotherapy,...περισσότερα »
Enhanced Optical Transmission through MacEtch-Fabricated Buried Metal Gratings
[image: Thumbnail image of graphical abstract] *Metallic films with subwavelength apertures*, integrated into a semiconductor by metal-assisted chemical etch (MacEtch), demonstrate enhanced transmission when compared to bare semiconductor surfaces. The resulting "buried" metallic structures are characterized spectroscopically and modeled using rigorous coupled wave analysis. These composite materials offer potential integration with optoelectronic devices, for simultaneous near-uniform electrical contact and strong optical coupling to free space. from #MedicinebyAlexandrosSfakianak... περισσότερα »
The imbalance of masticatory muscle activity affects the asymmetric growth of condylar cartilage and subchondral bone in rats
Publication date: March 2016 *Source:*Archives of Oral Biology, Volume 63 Author(s): Mutsumi Miyazaki, Ikuo Yonemitsu, Maki Takei, Ikuko Kure-Hattori, Takashi Ono ObjectiveTo examine the effects of imbalance of masticatory muscle activity of the rat mandible on the condylar cartilage and subchondral bone during the growth period.DesignForty 5-week-old male Wistar rats were randomly divided into experimental (n=20) and control (n=20) groups. In the experimental group, the left masseter muscles were resected. The rats were sacrificed at 7 or 9 weeks of age in both groups. Microcompute...περισσότερα »
The imbalance of masticatory muscle activity affects the asymmetric growth of condylar cartilage and subchondral bone in rats
Publication date: March 2016 *Source:*Archives of Oral Biology, Volume 63 Author(s): Mutsumi Miyazaki, Ikuo Yonemitsu, Maki Takei, Ikuko Kure-Hattori, Takashi Ono ObjectiveTo examine the effects of imbalance of masticatory muscle activity of the rat mandible on the condylar cartilage and subchondral bone during the growth period.DesignForty 5-week-old male Wistar rats were randomly divided into experimental (n=20) and control (n=20) groups. In the experimental group, the left masseter muscles were resected. The rats were sacrificed at 7 or 9 weeks of age in both groups. Microcompute...περισσότερα »
Pallet to Palate: Extending Shelf Life and Safety in Microgreens with PCR
[image: single_lettuce_plant_grown_using_hydropo] For producers of perishables with limited shelf life, shaving even a few days from on-site food safety procedures and getting the product into the hands of customers faster is a valuable goal. And that's exactly what Florida Urban Organics has done by implementing real-time PCR into their pathogen screening workflow. Florida Urban Organics is an innovative, certified Read the rest of this article The post Pallet to Palate: Extending Shelf Life and Safety in Microgreens with PCR appeared first on Accelerating Science. from #Medici... περισσότερα »
Methylator phenotype in colorectal cancer: a prognostic factor or not?
Publication date: Available online 7 December 2015 *Source:*Critical Reviews in Oncology/Hematology Author(s): C. Gallois, P. Laurent-Puig, J. Taieb Colorectal cancer (CRC) is due to different types of genetic alterations that are translated into different phenotypes. Among them, CpG island methylator phenotype (CIMP+) is the most recently involved in carcinogenesis of some CRC. The malignant transformation is in this case mainly due to the transcriptional inactivation of tumor suppressor genes. CIMP+ are reported to be more frequently found in the elderly and in women. The tumors a...περισσότερα »
RNAseq analysis for the diagnosis of muscular dystrophy
Abstract The precise genetic cause remains elusive in nearly 50% of patients with presumed neurogenetic disease, representing a significant barrier for clinical care. This is despite significant advances in clinical genetic diagnostics, including the application of whole-exome sequencing and next-generation sequencing-based gene panels. In this study, we identify a deep intronic mutation in the *DMD* gene in a patient with muscular dystrophy using both conventional and RNAseq-based transcriptome analyses. The implications of our data are that noncoding mutations likely comprise an ...περισσότερα »
