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Prevalence of Symptomatic and Asymptomatic Thrombosis in Pediatric Oncology Patients With Tunneled Central Venous Catheters: BackgroundPediatric oncology patients with tunneled central venous catheters (CVCs) are at increased risk to develop venous thromboembolic events (VTEs), but the true prevalence...
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[Reviews]: "Liquid biopsy" focusing on the analysis of circulating tumor cells (CTC) and circulating cell-free tumor DNA (ctDNA) in the blood of patients with cancer has received enormous attention because of its obvious clinical implications for personalized medicine. Analyses of CTCs and ctDNA have...
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MENA Promotes Tumor-Intrinsic Metastasis through ECM Remodeling and Haptotaxis [In the Spotlight]: Summary: Oudin and colleagues report a novel and specific function of MENA in mediating directional migration of breast cancer cells toward a fibronectin gradient of increasing concentration. This MENA-mediated...
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TCR Sequencing Can Identify and Track Glioma-Infiltrating T Cells after DC Vaccination: Although immunotherapeutic strategies are emerging as adjunctive treatments for cancer, sensitive methods of monitoring the immune response after treatment remain to be established. We used a novel next-generation...
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[Research Articles]: Fibronectin (FN) is a major component of the tumor microenvironment, but its role in promoting metastasis is incompletely understood. Here, we show that FN gradients elicit directional movement of breast cancer cells, in vitro and in vivo. Haptotaxis on FN gradients requires direct...
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Broadening Specificity and Enhancing Cytotoxicity of Adoptive T Cells for Nasopharyngeal Carcinoma Immunotherapy: Although promising, clinical responses to adoptive immunotherapy for nasopharyngeal carcinoma (NPC) are still limited by the restricted number of Epstein–Barr virus (EBV) antigens that can...
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in Immunotherapeutic Combination in Cancer, A Low-cost Drug Repurposed: Cancer immunotherapy has proven to be a potent treatment modality. Although often successful in generating antitumor immune responses, cancer immunotherapy is frequently hindered by tumor immune-escape mechanisms. Among immunosuppressive...
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Autoimmune Bullous Skin Disorders with Immune Checkpoint Inhibitors Targeting PD-1 and PD-L1: Monoclonal antibodies (mAb) targeting immune checkpoint pathways such as cytotoxic T-lymphocyte–associated protein 4 (CTLA-4) and programmed death 1 (PD-1) may confer durable disease control in several malignancies....
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in Mice: TNF is a potent promoter of carcinogenesis and potentially important target for cancer prevention. TNF is produced as functionally distinct transmembrane and soluble molecules (tmTNF and sTNF, respectively), but their individual roles in carcinogenesis are unexplored. We investigated the participation...
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Prediction Model for Barrett's Esophagus in Families: Background: Barrett's esophagus is often asymptomatic and only a small portion of Barrett's esophagus patients are currently diagnosed and under surveillance. Therefore, it is important to develop risk prediction models to identify high-risk individuals...
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Polyomaviruses and Subsequent Skin Cancer: Background: Merkel cell polyomavirus (PyV) is causally related to Merkel cell carcinoma, a rare skin malignancy. Little is known about the serostability of other PyVs over time or associations with cutaneous squamous cell carcinoma (SCC).Methods: As part of...
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Dietary Patterns and Plasma Sex Hormones: Background: Sex hormones are important for breast cancer, but it is unclear whether dietary patterns influence hormone concentrations.Methods: Dietary pattern adherence scores for the alternate Mediterranean diet (aMED), Dietary Approaches to Stop Hypertension...
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Cost-Effectiveness of See-and-Treat: Background: See-and-treat using loop electrosurgical excision procedure (LEEP) has been recommended as an alternative in managing high-grade cervical squamous intraepithelial lesions, but existing literature lacks evidence of the strategy's cost-effectiveness. We...
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Exercise, Weight Loss, and Inflammatory Markers: Background: We investigated the effect of equivalent weight loss, by a hypocaloric diet or mainly exercise, on inflammatory markers and adipokines in overweight postmenopausal women.Methods: Women were randomized to a diet (n = 97), mainly exercise (n...
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Pre-analytic Blood Collection Factors and Metabolomics: Background: Many epidemiologic studies are using metabolomics to discover markers of carcinogenesis. However, limited data are available on the influence of pre-analytic blood collection factors on metabolite measurement.Methods: We quantified 166...
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ACS Cancer Prevention Guidelines and Cancer Risk: Background: The American Cancer Society (ACS) publishes behavioral guidelines for cancer prevention, including standards on body weight, physical activity, nutrition, alcohol, and tobacco use. The impact of these guidelines has been rarely studied in...
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Shift Work, Chronotype, and Melatonin Patterns: Background: Shift work-related carcinogenesis is hypothesized to be mediated by melatonin; however, few studies have considered the potential effect modification of this underlying pathway by chronotype or specific aspects of shift work such as the number...
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Inherited Genetics and Exposure to Chemotherapy: Purpose: Cancer survivors express anxiety that chemotherapy exposure may lead to transmissible genetic damage in posttreatment children. Preclinical models suggest that chemotherapy exposure may result in considerable genomic alterations in postexposure...
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Particulate Matter and Cancer Mortality: Background: Few studies have assessed long-term effects of particulate matter (PM) with aerodynamic diameter < 2.5 μm (PM2.5) on mortality for causes of cancer other than the lung; we assessed the effects on multiple causes. In Hong Kong, most people live and...
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Comparative Oncology in Drug Development: Comparative oncology as a tool in drug development requires a deeper examination of the value of the approach and examples of where this approach can satisfy unmet needs. This review seeks to demonstrate types of drug development questions that are best answered...
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An Alternative for Patient-Derived Xenograft: Purpose: Targeted therapy (TT) provides highly effective cancer treatment for appropriately selected individuals. A major challenge of TT is to select patients who would benefit most.Experimental Design: The study uses cancer material from 25 patients primarily...
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Evaluation of PF-03446962 in Patients with Solid Tumors: Purpose: Objectives of this dose-finding study were to determine the MTD and recommended phase II dose (RP2D) of the first-in-class anti-activin receptor-like kinase 1 (ALK-1) monoclonal antibody PF-03446962, and assess safety and antitumor activity...
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Myeloid DCs Induce Effective Responses in Melanoma Patients: Purpose: Thus far, dendritic cell (DC)-based immunotherapy of cancer was primarily based on in vitro–generated monocyte-derived DCs, which require extensive in vitro manipulation. Here, we report on a clinical study exploiting primary CD1c+...
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Pseudoprogression/Radionecrosis and Kinetic FET-PET: Purpose: Pseudoprogression (PsP) is characterized by therapy-associated but not tumor growth–associated increases of contrast-enhancing glioblastoma lesions on MRI. Although typically occurring during the first 3 months after radiochemotherapy, PsP...
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Optimizing Doses and Schedules of Small Targeted Drugs: Tolerability of molecularly targeted agents (MTA) used in cancer therapeutics is determined in phase I trials. We reviewed the reported incidence of toxicity in phase III trials at doses and schedules recommended by phase I trials to evaluate whether...
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Publication date: Available online 9 May 2016Source:Computer Speech & Language Author(s): Houman Ghaemmaghami, David Dean, Sridha Sridharan, David A. van Leeuwen This paper proposes the task of speaker attribution as speaker diarization followed by speaker linking. The aim of attribution is to...
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Question 1: Interventional audiology? I'm not too sure exactly what that is? Answer: Well, it can be a lot of different things. In general, when we use the term interventional audiology, we are referring to direct involvement with people who have hearing loss or self-reported difficulties with their...
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Publication date: Available online 8 May 2016Source:Gait & Posture Author(s): Christopher J. Burcal, Erik A. Wikstrom Performing a cognitive task while balancing can result in either increased or decreased sway depending on the nature of the cognitive task, and is commonly used in pathologic populations...
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Publication date: Available online 8 May 2016Source:Gait & Posture Author(s): Jinkyu Lee, Yoon No Gregory Hong, Choongsoo S. Shin The mid-foot contact area relative to the total foot contact area can facilitate foot arch structure evaluation. A stair descent motion consistently provides initial...
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Objective. The most effective nonpharmacological treatment for insomnia disorder is cognitive behavioural therapy-insomnia (CBT-i). However CBT-i may not suit everyone. Auricular acupuncture (AA) is a complementary treatment. Studies show that it may alleviate insomnia symptoms. The aim of this randomised...
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: a comparison between two sampling techniques: AbstractPre operative biopsy is important in obtaining preliminary information that may help in tailoring the optimal treatment. The aim of this study was to compare two sampling techniques of obtaining nasal biopsy–nasal forceps and nasal scissors...
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: more common than expected?: AbstractThe overall complication rate of cochlear implant surgery is low and so-called electrode failures (electrode migration, misplacement, etc.,) account for only a minority of all complications. The aim of this study was to explore the prevalence of electrode migration...
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The effects of bone pâté on human osteoblasts cell cultures: AbstractThe aim of the present study was to evaluate the effect of bone pate on human osteoblast differentiation by measuring cell viability, alkaline phosphatase activity and expression of the transcription factors and of the major components...
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: the impact of change in surgical strategy and training procedures: AbstractSurgery for primary hyperparathyroidism (pHPT) has a high cure-rate and few complications. Preoperative localization procedures have permitted a dramatic shift from routine bilateral exploration to focused, minimally invasive...
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Non-allergic rhinitis with eosinophilia syndrome is not associated with local production of specific IgE in nasal mucosa: AbstractNon-allergic rhinitis with eosinophilia syndrome (NARES) is an eosinophilic inflammation of the nasal mucosa without evidence of an allergy or other nasal pathologies. Patients...
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Audiologic profile of OSAS and simple snoring patients: the effect of chronic nocturnal intermittent hypoxia on auditory function: AbstractThe objective of this work was to study the effect of nocturnal intermittent hypoxia on auditory function of simple snoring patients and subjects affected by OSAS;...
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Atypical radiographic features of skull base cholesterol granuloma: AbstractCholesterol granulomas (CGs) are the most common benign lesions of the petrous apex (PA) and have distinct computed tomography (CT) and magnetic resonance imaging (MRI) characteristics. On CT, CGs of the PA (PACG) present as...
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: a 6-year cohort analysis in a tertiary academic hospital: AbstractInverted papillomas may affect the (para)nasal cavity. While some of these papillomas can undergo malignant transformation, others grow slowly and cause few if any symptoms. An endoscopic approach is seen as providing a balance between...
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Assessment of the effect of deviated nasal septum on the structure of nasal cavity: AbstractThe present study was aimed to investigate the effects of DNS on the structure of nasal cavity. The paranasal sinus coronal view CT of 108 patients with DNS and 129 hospitalized patients without DNS was retrospectively...
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Publication date: June–July 2016Source:Brain and Language, Volumes 157–158 Author(s): Chantel S. Prat, Brianna L. Yamasaki, Reina A. Kluender, Andrea Stocco Understanding the neurobiological basis of individual differences in second language acquisition (SLA) is important for research on bilingualism,...
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Publication date: Available online 7 May 2016Source:Brazilian Journal of Otorhinolaryngology Author(s): João Mangussi-Gomes, Fernando Danelon-Leonhardt, Guilherme Figner Moussalem, Nicolas Galat Ahumada, Cleydson Lucena Oliveira, Flávio Carneiro Hojaij IntroductionSquamous cell carcinoma (SCC) of the...
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Detection of multiple viral infections in cattle and buffalo with suspected vesicular disease in Brazil. J Vet Diagn Invest. 2016 May 6; Authors: Laguardia-Nascimento M, Sales ÉB, Gasparini MR, de Souza NM, da Silva JA, Souza GG, Carani FR, Dos Santos AF, Rivetti Júnior AV, Camargos MF, Fonseca Júnior...
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Related Articles Effect of interprofessional clinical education programme length on students' attitudes towards teamwork. J Interprof Care. 2016 May;30(3):338-46 Authors: Renschler L, Rhodes D, Cox C Abstract This article reports on a study involving a range of health professions students who...
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Matching heard and seen speech: An ERP study of audiovisual word recognition. Brain Lang. 2016 May 4;157-158:14-24 Authors: Kaganovich N, Schumaker J, Rowland C Abstract Seeing articulatory gestures while listening to speech-in-noise (SIN) significantly improves speech understanding. However, the...
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Diagnosis and Treatment of Eosinophilic Esophagitis in Adults. Am J Med. 2016 May 4; Authors: Kavitt RT, Hirano I, Vaezi MF Abstract Eosinophilic esophagitis is a relatively recently discovered disease of increasing incidence and prevalence and is a common cause of dysphagia and food bolus impaction....
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Robotic transhiatal excision of epiphrenic diverticula. J Robot Surg. 2016 May 6; Authors: Hukkeri VS, Jindal S, Qaleem M, Tandon V, Govil D Abstract An epiphrenic oesophageal diverticulum is most commonly a pulsion diverticulum which develops consequent to protrusion of mucosa through the muscular...
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Acute opercular syndrome in 4-year-old boy. Neurol Neurochir Pol. 2016 May-Jun;50(3):185-189 Authors: Pniewska A, Pawłowska M Abstract Acute opercular syndrome is a rare described syndrome caused by a sudden damage of the cerebral cortex and subcortical white matter, located around the insula....
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Publication date: July 2016Source:Oral Oncology, Volume 58 Author(s): Alexey Surov, Patrick Stumpp, Hans Jonas Meyer, Matthias Gawlitza, Anne-Kathrin Höhn, Andreas Boehm, Osama Sabri, Thomas Kahn, Sandra Purz ObjectivesTo analyze possible associations between functional simultaneous 18F-FDG-PET/MR...
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Publication date: July 2016Source:Gait & Posture, Volume 48 Author(s): Yangjian Huang, Junkai Xu, Bo Yu, Peter B. Shull BackgroundIncreased physical activity can provide numerous health benefits. The relationship between physical activity and health assumes reliable activity measurements including...
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David Gergen and Roy Green Arizona Cardinals legend Roy Green is probably best known for his speed that got him the 4.2 time in the 40 yard sprint. In fact, his out of this world speed and world class skill landed him the nickname "Jetstream" and earned him the respect of the greatest players across...
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Abstract Squamous cell carcinoma (SCC) of the tongue is the most common oral cancer. Most cases occur on the lateral border of the tongue and only very rarely on the dorsum. We retrospectively investigated the incidence of SCC of the tongue dorsum in our department between April 2006 and March 2015....
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Abstract Esthesioneuroblastoma is a rare malignant neoplasm of oflactory neuroepithelium and usually located at the olfactory cleft at superior nasal cavity. Ectopic localization of esthesioneuroblastoma is even rarer and usually posed with a diagnostic dilemma and delay in the diagnosis and management,...
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Abstract Esthesioneuroblastoma is a rare malignant neoplasm of oflactory neuroepithelium and usually located at the olfactory cleft at superior nasal cavity. Ectopic localization of esthesioneuroblastoma is even rarer and usually posed with a diagnostic dilemma and delay in the diagnosis and management,...
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Abstract The uncommon ear tumor of middle ear squamous cell carcinoma (MESCC) is thought to be associated with the history of long-term chronic otitis media in the most cases. The main etiologic factor of MESCC is still unclear and may be multifactorial. Infections of Epstein-Barr virus (EBV) and Human...
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Abstract The uncommon ear tumor of middle ear squamous cell carcinoma (MESCC) is thought to be associated with the history of long-term chronic otitis media in the most cases. The main etiologic factor of MESCC is still unclear and may be multifactorial. Infections of Epstein-Barr virus (EBV) and Human...
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Abstract Squamous cell carcinoma (SCC) of the tongue is the most common oral cancer. Most cases occur on the lateral border of the tongue and only very rarely on the dorsum. We retrospectively investigated the incidence of SCC of the tongue dorsum in our department between April 2006 and March 2015....
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Abstract Parry Romberg syndrome is a rare condition with unknown etiopathogenesis characterized by unilateral hemiatrophy of face leading to cosmetic disability which may be complicated by neurological features such as epilepsy, headache, trigeminal neuralgia etc. Management comprises of reconstructive...
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Abstract Parry Romberg syndrome is a rare condition with unknown etiopathogenesis characterized by unilateral hemiatrophy of face leading to cosmetic disability which may be complicated by neurological features such as epilepsy, headache, trigeminal neuralgia etc. Management comprises of reconstructive...
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Publication date: July 2016Source:Oral Oncology, Volume 58 Author(s): Alexey Surov, Patrick Stumpp, Hans Jonas Meyer, Matthias Gawlitza, Anne-Kathrin Höhn, Andreas Boehm, Osama Sabri, Thomas Kahn, Sandra Purz ObjectivesTo analyze possible associations between functional simultaneous 18F-FDG-PET/MR...
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How, When, And From Whom Neck Dissection Operative Technique Is Learned: An International Survey on Neck Dissection Education Among Head and Neck Oncologic Surgeonsvia American Journal of OtolaryngologySource:American Journal of OtolaryngologyAuthor(s): Shirin Hemmat, Steven J. Wang, William R. RyanBackgroundThere...
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The physiologic role of via American Journal of OtolaryngologySource:American Journal of OtolaryngologyAuthor(s): Zachary Farhood, Paul R. LambertMultiple options exist to manage Ménière's disease (MD), ranging from dietary modifications to ablative surgery. Corticosteroids (CS) have long been used to...
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Main ArticleCell origin in the macula flava of the human newborn vocal foldK Satoa1 c1, S Chitosea1, T Kuritaa1 and H Umenoa1a1 Department of Otolaryngology – Head and Neck Surgery, Kurume University School of Medicine, JapanAbstractBackground: There is growing evidence to suggest that cells in the maculae...
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: What to do with an Unexpected Pathology Result?via American Journal of OtolaryngologySource:American Journal of OtolaryngologyAuthor(s): Michael B. Hall, Marc R. Rosen, Kurren Gill, Gurston G. NyquistBackgroundEndoscopic sinus surgery has become the mainstay in surgical treatment of sinusitis and nasal...
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Comparison of Patient- and Practitioner-Reported JAMA Otolaryngol Head Neck Surg. 2016 May 5;Authors: Falchook AD, Green R, Knowles ME, Amdur RJ, Mendenhall W, Hayes DN, Grilley-Olson JE, Weiss J, Reeve BB, Mitchell SA, Basch EM, Chera BSAbstract Importance: Agreement between patient- and practitioner-reported...
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Comparison of Conventional, Revascularized, and Bioengineered Methods of JAMA Otolaryngol Head Neck Surg. 2016 May 5;Authors: Sand JP, Park AM, Bhatt N, Desai SC, Marquardt L, Sakiyama-Elbert S, Paniello RCAbstract Importance: Damage to the recurrent laryngeal nerve (RLN) is highly detrimental...
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Authors: Nicoletti P, Bansal M, Lefebvre C, Guarnieri P, Shen Y, Pe'er I, Califano A, Floratos AAbstract Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) represent rare but serious adverse drug reactions (ADRs). Both are characterized by distinctive blistering lesions and...
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Authors: Terraneo L, Lava SA, Camozzi P, Zgraggen L, Simonetti GD, Bianchetti MG, Milani GPAbstract BACKGROUND: Maculopapular or urticarial eruptions and erythema multiforme sometimes occur in patients affected with Mycoplasma pneumoniae respiratory infections. Further eruptions have also been...
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Authors: Bentele-Jaberg N, Guenova E, Mehra T, Nägeli M, Chang YT, Cozzio A, French LE, Hoetzenecker WAbstract We describe the case of a 32-year-old woman who presented to the hospital with generalized painful exanthema, blisters and erosions 1 month after giving birth to a healthy girl. The...
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Pan Afr Med J. Houyam Moundib1,& and Fouzia Hali11Department of Dermatology and Venereology, University Hospital Ibn Rochd, Casablanca, Morocco&Corresponding author: Houyam Moundib, Department of Dermatology and Venereology, University Hospital Ibn Rochd, Casablanca, MoroccoA 55 years old woman,...
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Diagnostic Delay and Amniotic Membrane Transplantation in a Child With Atypical Stevens-Johnson Syndrome.J Pediatr Ophthalmol Strabismus.Authors: Gervasio KA, Wu AYAbstract A 4-year-old boy presented with a 6-day history of severe non-limbic-sparing conjunctivitis. Atypical Stevens-Johnson syndrome...
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Quality of life in via International Journal of Pediatric OtorhinolaryngologyPublication date: July 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 86Author(s): Karolijn Dulfer, Manouk J.S. van Lieshout, Marc P. van der Schroeff, Maarten J. Koudstaal, Irene M.J. Mathijssen,...
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Twice-weekly palliative radiotherapy for locally very advanced head and neck cancersIndian J Cancer. 2016 ;Authors: Murthy V, Kumar DP, Budrukkar A, Gupta T, Ghosh-Laskar S, Agarwal JAbstract PURPOSE: The purpose of the following study is to evaluate the efficacy of a twice-weekly hypofractionated...
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Main ArticleRhinosinusitis associated with post-dental extraction chronic oroantral fistula: outcomes of non-surgical management comprising antibiotics and local decongestion therapyA K Mishraa1 c1, V R Sinhaa1, A Nilakantana1 and D K Singha1a1 Department of Otorhinolaryngology – Head and Neck Surgery,...
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through an anatomical study on cadaversvia ScienceDirect Publication: Brazilian Journal of OtorhinolaryngologyPublication date: Available online 6 May 2016Source:Brazilian Journal of OtorhinolaryngologyAuthor(s): Andressa Vinha Zanuncio, Paulo Fernando Tormin Borges Crosara, Helena Maria Gonçalves Becker,...
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P120ctn may participate in epithelial-mesenchymal transition in OSCC: C Zhong, Z Zuo, Qing Ji, D FengIndian Journal of Cancer 2016 53(1):20-24Aim: Oral squamous cell carcinoma (OSCC) is the eighth most common cause of cancer death. OSCC cells can easily invade tissues and metastasize to the cervical...
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Cell division patterns and chromosomal segregation defects in oral cancer stem cells: AbstractOral squamous cell carcinoma (OSCC) is a serious public health problem caused primarily by smoking and alcohol consumption or human papillomavirus. The cancer stem cell (CSC) theory posits that CSCs show unique...
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Avoiding Severe Toxicity From Combined BRAF Inhibitor and Radiation Treatment: Consensus Guidelines from the Eastern Cooperative Oncology Group (ECOG)via International Journal of Radiation Oncology*Biology*PhysicsPublication date: 1 June 2016Source:International Journal of Radiation Oncology*Biology*Physics,...
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Bispecific Antibodies Selectively Target Cancer: Purpose: CD47 is highly expressed on a variety of tumor cells. The interaction of CD47 with SIRPα, a protein on phagocytic cells, transmits a "don't eat me" signal that negatively regulates phagocytosis. CD47-SIRPα antagonists enable phagocytosis by disrupting...
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Prognostic performance of pre-treatment NLR and PLR in patients suffering from osteosarcoma: AbstractBackgroundInflammatory response markers have been proposed to predict the clinical outcomes in various cancers. The aim of this study was to explore the influence of the neutrophil-to-lymphocyte ratio...
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Improvement in short-term outcomes after esophagectomy with a multidisciplinary perioperative care team: AbstractBackgroundEsophagectomy for patients with esophageal cancer remains a high-risk surgery. We introduced a multidisciplinary perioperative management team in the Cancer Institute Hospital (PeriCan)...
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Hoyeraal-Hreidarsson syndromeFrom Wikipedia, the free encyclopediaHoyeraal-Hreidarsson syndromeClassification and external resourcesSpecialtymedical geneticsICD-10Q82.8ICD-9-CM757.39OMIM305000DiseasesDB32955MeSHC536068Hoyeraal-Hreidarsson syndrome (HHS) is a very rare multisystem X-linked recessive disorder...
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“No patient left behind”: an alternative to “the War on Cancer” metaphor: AbstractThe War on Cancer began with President Nixon’s National Cancer Act of 1971. Treatment-related ‘collateral damage’ to healthy cells and tissues that reduces quality of life is an unfortunate but inevitable consequence of...
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Zika virus and Zika fever: AbstractAn emerging mosquito-borne arbovirus named Zika virus (ZIKV), of the family Flaviviridae and genus Flavivirus, is becoming a global health threat. ZIKV infection was long neglected due to its sporadic nature and mild symptoms. However, recently, with its rapid spread...
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Phylogenetic analysis revealed the central roles of two African countries in the evolution and worldwide spread of Zika virus: AbstractRecent outbreaks of Zika virus (ZIKV) infections in Oceania's islands and the Americas were characterized by high numbers of cases and the spread of the virus to new...
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Pulmonary Lymphomatoid Granulomatosis- a Case Report with Review of Literature: AbstractLymphomatoid granulomatosis is a rare, Epstein Barr Virus (EBV)-associated systemic angiodestructive disorder that may progress to a diffuse large B cell lymphoma. Pulmonary involvement occurs in over 90 % cases followed...
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Predictive Gene Signatures for HNSCC Cetuximab-Chemotherapy: Cetuximab-platinum chemotherapy is used for recurrent-metastatic head and neck squamous cell carcinoma (HNSCC), however a minority of patients benefit. Gene expression profiling (GEP) of HNSCCs with prolonged responses to cetuximab-chemotherapy...
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Role of the AHR in Oral Cancer Migration and Tumorigenesis: Over 45,000 new cases of oral and pharyngeal cancers are diagnosed and account for over 8,000 deaths a year in the United States. An environmental chemical receptor, the aryl hydrocarbon receptor (AHR), has previously been implicated in oral...
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Feasibility of automated proton therapy plan adaptation for head and neck tumors using cone beam CT images: AbstractBackgroundIntensity modulated proton therapy (IMPT) of head and neck (H&N) tumors may benefit from plan adaptation to correct for the dose perturbations caused by weight loss and tumor...
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Phase 2 Study of A prospective phase 2 study was conducted to evaluate the clinical utility of acupuncture-like transcutaneous nerve stimulation (ALTENS) for the treatment of chemotherapy-induced peripheral neuropathy (CIPN). Eligible cancer patients had a < 2 ECOG performance score, received neurotoxic...
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in complete monitor view: a suitable method of thoracoscopic sleeve lobectomy for non-small cell lung cancer: AbstractBackgroundOur study aims to determine the value of bronchial anastomosis using complete continuous suture.MethodsSix patients diagnosed with central lung carcinoma who were candidates...
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: a Unique Entity?: AbstractPurposeLiposarcoma is the most common soft tissue sarcoma in adults. It represents approximately 20 % of all mesenchymal malignancies. It most frequently involves retroperitoneum, trunk, and extremities. Hypopharyngeal and esophageal localization of liposarcoma is extremely...
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in fresh human cadavers: basis for sentinel node biopsy: AbstractBackgroundWhile the optimal management of early breast cancer patients with sentinel lymph node (SLN) involvement mapped in the internal thoracic chain is still debated, biopsy may be performed when surgeons select patients who are most...
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Feasibility of automated proton therapy plan adaptation for head and neck tumors using cone beam CT imagesAbstractBackgroundIntensity modulated proton therapy (IMPT) of head and neck (H&N) tumors may benefit from plan adaptation to correct for the dose perturbations caused by weight loss and tumor...
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An Evaluation of Current Measures for Needle and Syringe Program Coverage: Needle and syringe program (NSP) coverage is commonly used to assess NSP effectiveness. However, existing measures don't capture whether persons who inject drugs (PWIDs) stockpile syringes, an important and novel aspect of NSP...
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The Generation R Study: -3 and -6 polyunsaturated fatty acids are important for brain function and development. We examined whether maternal polyunsaturated fatty acid status during pregnancy affects risk of autistic traits in childhood. Within the Generation R cohort, we measured maternal plasma polyunsaturated...
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A Longitudinal Study of the Impact of the Earned Income Tax Credit: Although adverse socioeconomic conditions are correlated with worse child health and development, the effects of poverty-alleviation policies are less understood. We examined the associations of the Earned Income Tax Credit (EITC) on...
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Invited Commentary: Using Financial Credits as Instrumental Variables for Estimating the Causal Relationship Between Income and Health: Social epidemiologists are interested in determining the causal relationship between income and health. Natural experiments in which individuals or groups receive income...
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A Large International Population-Based Study: Maternal cigarette smoking is a well-established risk factor for oral clefts. Evidence is less clear for passive (secondhand) smoke exposure. We combined individual-level data from 4 population-based studies (the Norway Facial Clefts Study, 1996–2001; the...
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Among Women and Men in 2 Prospective Cohort Studies: Few studies have assessed the relationship between sunburn and risk of different skin cancers (melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC)) in prospective studies simultaneously, and little is known about the association...
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Authors: Nyegaard M, Rendtorff ND, Nielsen MS, Corydon TJ, Demontis D, Starnawska A, Hedemand A, Buniello A, Niola F, Overgaard MT, Leal SM, Ahmad W, Wikman FP, Petersen KB, Crüger DG, Oostrik J, Kremer H, Tommerup N, Frödin M, Steel KP, Tranebjærg L, Børglum ADAbstract Nonsyndromic hearing...
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Barriers to early cochlear implantation.:Int J Audiol. 2016 May 3;:1-13Authors: Dettman S, Choo D, Dowell RAbstract OBJECTIVE: Identify variables associated with paediatric access to cochlear implants (CIs). DESIGN: Part 1. Trends over time for age at CI surgery (N = 802) and age at hearing...
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Am J Hum Genet. 2006 Nov; 79(5): 935–941.Published online 2006 Sep 26. doi: 10.1086/508433PMCID: PMC1698566A Novel Mutation in FGFR3 Causes Camptodactyly, Tall Stature, and Hearing Loss (CATSHL) SyndromeReha M. Toydemir, Anna E. Brassington, Pınar Bayrak-Toydemir, Patrycja A. Krakowiak, Lynn B. Jorde, Frank...
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Clinical and molecular findings in three Moroccan families with distal renal tubular acidosis and deafness: Report of a novel mutation of ATP6V1B1 gene.:Authors: Boualla L, Jdioui W, Soulami K, Ratbi I, Sefiani AAbstract BACKGROUND: Primary distal renal tubular acidosis (dRTA) is a rare genetic...
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Reconstruction of an Extensive Midfacial Defect Using Additive Manufacturing Techniques: AbstractMalignant peripheral nerve sheath tumors are extremely rare tumors arising in peripheral nerves. Only 17 cases involving the trigeminal nerve have ever been reported. These tumors have a very poor prognosis...
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A Case Report: Varicella zoster virus (VZV) is responsible for the primary infection chickenpox. After the initial infection, it remains latent but can reactivate, resulting in shingles (herpes zoster). Previous reports have implicated VZV in the pathogenesis of apical periodontitis, but the involvement...
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s in experimental hematogenously disseminated candidiasisvia Acta BiomaterialiaPublication date: Available online 2 May 2016Source:Acta BiomaterialiaAuthor(s): Catarina Carneiro, Alexandra Correia, Tânia Lima, Manuel Vilanova, Célia Pais, Andreia C. Gomes, M. Elisabete C.D. Real Oliveira, Paula SampaioWe...
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a randomized study in dogs: AbstractObjectiveSoft tissue (ST) dehiscence with graft exposure is a frequent complication of vertical augmentation. Flap dehiscence is caused by failure to achieve tension-free primary wound closure and by the impairment of flap microcirculation due to surgical trauma.Soft...
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Accuracy of Schneiderian membrane thickness: a cone-beam computed tomography analysis with histological validation: AbstractObjectivesCone-beam computed tomography (CBCT) has been used in the literature to evaluate Schneiderian membrane thickness (SMT), but its accuracy has never been validated. The...
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Ectomesenchymal Chondromyxoid Tumour of the Dorsal Tongue Presenting with Impaired Speech: Ectomesenchymal chondromyxoid tumours (ECTs) are rare mesenchymal soft tissue neoplasms that typically present as a slow-growing asymptomatic mass on the anterior dorsum of the tongue. Our patient presented with...
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Evidence-based guidelines for recommending cochlear implantation for young children: Audiological criteria and optimizing age at implantation: 10.3109/14992027.2016.1157268<br/>Jaime R. LeighAbstractObjective: Establish up-to-date evidence-based guidelines for recommending cochlear implantation...
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Predictive Factors for Medical Consultation for Sore Throat in Adults with Recurrent Pharyngotonsillitis: Objects. To seek patient- and episode-related factors that associate with medical consultation for acute sore throat because these factors may affect the patient being referred to specialist care...
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Diagnostic Performance of Whole-Body PET/MRI for Detecting Malignancies in Cancer Patients: A Meta-Analysis: by Guohua Shen, Shuang Hu, Bin Liu, Anren KuangBackground As an evolving imaging modality, PET/MRI is preliminarily applied in clinical practice. The aim of this study was to assess the diagnostic...
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Self-Administered Domiciliary tDCS Treatment for Tinnitus: A Double-Blind Sham-Controlled Study: by Petteri Hyvärinen, Antti Mäkitie, Antti A. AarnisaloTranscranial direct current stimulation (tDCS) has shown potential for providing tinnitus relief, although positive effects have usually been observed...
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The telomere proteins in tumorigenesis and clinical outcomes of oral squamous cell carcinoma: Telomeres are the distal ends of linear eukaryotic chromosomes and are composed of tandemly repeated DNA elements 5′-TTAGGG-3′. These terminal sequences are capped by specific telomeric proteins and adopt a...
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Leitlinie: „HNO-spezifische Therapie der obstruktiven Schlafapnoe bei Erwachsenen“ Kurzfassung: ZusammenfassungDie hier vorgelegte S2e-Leitlinie ist die Aktualisierung der Vorgängerleitlinie „Therapie der obstruktiven Schlafapnoe des Erwachsenen“. Die Aktualisierung erfolgte im Auftrag der Deutschen...
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Die vestibulären Kopfgelenke: ZusammenfassungEinleitungDer Stellenwert zervikaler Propriozeption für das menschliche Gleichgewichtsempfinden ist bis heute nicht zufriedenstellend geklärt. Ziel der vorliegenden Arbeit war die selektive zervikovestibuläre Provokation mithilfe eines neuen und eigens konstruierten...
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Einfluss einer Hörgeräteversorgung auf das Einsilberverstehen und das subjektiv erlebte Alltagshören
Einfluss einer Hörgeräteversorgung auf das Einsilberverstehen und das subjektiv erlebte Alltagshören: ZusammenfassungHintergrundDie Ton- und Sprachaudiometrie sind wichtige Untersuchungen für die Hörgeräteindikation und die Hörgerätekontrolle. Bei jeder Hörgerätversorgung steht für den Patienten jedoch...
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in a Vertebrate with Internally Coupled Ears
Risk factors associated with post extubation stridor in the trauma intensive care unit
The American Journal of Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1VQfdT2 via IFTTT
Damage to the blood-aqueous barrier in ocular blunt trauma and its association with intraocular pressure elevation
Ophthalmic Research from Emergency Medicine via ola Kala on Inoreader http://ift.tt/21NPtXo via IFTTT
Extravasation risk using ultrasound guided peripheral intravenous catheters for computed tomography contrast administration
Academic Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1ZwlCRy via IFTTT
Synuclein aggregation: When the mouse’s away the human will play
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 7 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1WV2vl0 via IFTTT
Optimizing odor identification testing as quick and accurate diagnostic tool for Parkinson’s disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 7 δευτερόλεπτα
ABSTRACT Introduction The aim of this study was to evaluate odor identification testing as a quick, cheap, and reliable tool to identify PD. Methods Odor identification with the 16-item Sniffin’ Sticks test (SS-16) was assessed in a total of 646 PD patients and 606 controls from three European centers (A, B, and C), as well […]
Expanding the genetic spectrum of paroxysmal dyskinesias
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 7 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/23BgwEx via IFTTT
Thermal Response of In Vivo Human Skin to Fractional Radiofrequency Microneedle Device
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 7 δευτερόλεπτα
Background. Fractional radiofrequency microneedle system (FRMS) is a novel fractional skin resurfacing system. Data on thermal response to this fractional resurfacing technique is limited. Objectives. To investigate histologic response of in vivo human skin to varying energy settings and pulse stacking of a FRMS in dark-skinned subjects. Methods. Two female volunteers who were scheduled for […]
Effect of Corilagin on the Proliferation and NF-κB in U251 Glioblastoma Cells and U251 Glioblastoma Stem-Like Cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 7 δευτερόλεπτα
Background. This study is to explore the effect of corilagin on the proliferation and NF-κB signaling pathway in U251 glioblastoma cells and U251 glioblastoma stem-like cells. Methods. CD133 positive U251 glioblastoma cells were separated by immunomagnetic beads to isolate glioblastoma stem-like cells. U251 cells and stem-like cells were intervened by different corilagin concentrations (0, 25, […]
Fractional Carbon Dioxide Laser for Keratosis Pilaris: A Single-Blind, Randomized, Comparative Study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 7 δευτερόλεπτα
Objective. Keratosis pilaris (KP) is a common condition which can frequently be cosmetically disturbing. Topical treatments can be used with limited efficacy. The objective of this study is to evaluate the effectiveness and safety of fractional carbon dioxide (CO2) laser for the treatment of KP. Patients and Methods. A prospective, randomized, single-blinded, intraindividual comparative study […]
Identification of Intragenic Exon Deletions and Duplication of TCF12 by Whole Genome or Targeted Sequencing as a Cause of TCF12-Related Craniosynostosis
ABSTRACT TCF12-related craniosynostosis can be caused by small heterozygous loss-of-function mutations in TCF12. Large intragenic rearrangements, however, have not been described yet. Here, we present the identification of four large rearrangements in TCF12 causing TCF12-related craniosynostosis. Whole genome sequencing was applied on the DNA of eighteen index-cases with coronal synostosis and their family members (forty-three… Continue reading Identification of Intragenic Exon Deletions and Duplication of TCF12 by Whole Genome or Targeted Sequencing as a Cause of TCF12-Related Cran... περισσότερα »
Identification of Intellectual Disability Genes in Female Patients with A Skewed X Inactivation Pattern
ABSTRACT Intellectual disability (ID) is a heterogeneous disorder with an unknown molecular etiology in many cases. Previously, X-linked ID (XLID) studies focused on males due to the hemizygous state of their X chromosome. Carrier females are generally unaffected due to the presence of a second normal allele, or inactivation of the mutant X chromosome in… Continue reading Identification of Intellectual Disability Genes in Female Patients with A Skewed X Inactivation Pattern
Interactive Exploration, Analysis and Visualization of Complex Phenome-Genome Datasets with ASPIREdb
ABSTRACT Identifying variants causal for complex genetic disorders is challenging. With the advent of whole exome and genome sequencing, computational tools are needed to explore and analyze the list of variants for further validation. Correlating genetic variants with subject phenotype is crucial for the interpretation of the disease causing mutations. Often such work is done… Continue reading Interactive Exploration, Analysis and Visualization of Complex Phenome-Genome Datasets with ASPIREdb
Cleft sidedness and congenitally missing teeth in patients with cleft lip and palate patients
The aim of this study was to investigate the prevalence of cleft sidedness, and the number of congenitally missing teeth in regard to cleft type and gender. from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1OaSFKe via IFTTT
Reevaluation of postoperative radiation dose in the management of human papillomavirus–positive oropharyngeal cancer
Reevaluation of postoperative radiation dose in the management of human papillomavirus–positive oropharyngeal cancer: Abstract Background The purpose of this study was to compare outcomes of patients with p16-positive oropharyngeal squamous cell carcinoma (SCC) treated with postoperative intensity-modulated radiotherapy (IMRT) before and after an institutional dose reduction policy effective on February 2009. Methods Between 1998 and 2013, 175 consecutive patients with p16-positive oropharyngeal SCC with extracapsular extension (ECE) and/or close or positive margins were treated pos... περισσότερα »
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas
[image: cover.gif?v=1&s=675d07de70e90879b0ebc822] Background Epigenetic modifications, including DNA methylation of tumor suppressor genes carried out by DNA methyltransferases (DNMTs), are important events in carcinogenesis. Although there are studies concerning to its expression in several cancer types, DNMTs expression pattern is not known in photoinduced lip carcinogenesis. The aim of this study was to investigate the immunoexpression of DNMTs 1, 3a, and 3b in lip precancerous lesion (actinic cheilitis) and cancer. Methods Thirty cases of actinic cheilitis (AC), thirty cases o... περισσότερα »
Comparison of centring ability and transportation between four nickel titanium instrumentation techniques by micro-computed tomography (μCT)
Abstract Aim To compare the centring ability and transportation of ProTaper Next (PTN), ProTaper Universal (PTU), Race 123 and Revo S using micro computed tomography (μCT). Methodology Sixty mesial root canals of thirty mandibular molars were divided virtually into coronal, middle and apical thirds and two reproducible reference points were marked on the external surface of the roots creating 360 measurement points. Samples were randomly allocated to four NiTi instrumentation techniques. Group 1: PTU up to F2 (n=16), group 2: PTN up to X2 (n=18), group 3: Race 123 up to T2 (n=12), ... περισσότερα »
Blood analyses may predict risk of delirium in older surgical patients
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 22 δευτερόλεπτα
Markers may help identify patients who would benefit from preventive measures against delirium. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1T0le9Q via IFTTT
Zika virus may cause microcephaly by hijacking human immune molecule
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 22 δευτερόλεπτα
The U.S. Centers for Disease Control and Prevention recently concluded that Zika virus infection in pregnant women can stunt neonatal brain development, leading to babies born with abnormally small… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1T0le9W via IFTTT
Putting the spotlight on folic acid supplementation in pregnancy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 22 δευτερόλεπτα
Future Science Group (FSG) has announced the publication of a new article in Future Science OA, reviewing national and international guidelines for folic acid supplementation, and analyzing its… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/21NvxDZ via IFTTT
Study of elite paralympic athletes supports benefits of exercise for children with cerebral palsy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 22 δευτερόλεπτα
For highly trained Paralympic athletes with cerebral palsy (CP), bone mineral density and other measures of body composition are similar to those of able-bodied adults of similar age, reports a study… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/276Xb2B via IFTTT
Idiopathic sclerosing encapsulating peritonitis presenting as a right iliac fossa mass in a teenaged girl
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 22 δευτερόλεπτα
Sclerosing encapsulating peritonitis (SEP) is a rare peritoneal condition characterised by a firm and thick membrane that encases a part of or the whole of the small intestine. It can be idiopathic or secondary to a variety of conditions. It usually presents as an acute or subacute small bowel obstruction, however, the presentation can vary. […]
Gingival leiomyomatous hamartoma of the maxilla: a rare entity
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 22 δευτερόλεπτα
Hamartoma is a tumour-like malformation appearing as a focal overgrowth of normal cells. Leiomyomatous hamartomas (LHs) are rare in the oral cavity and commonly seen in the Japanese and less than 40 cases have been reported in the Japanese and English literature. The clinical differential diagnoses are irritational (traumatic) fibroma and congenital epulis. It has […]
Scrub typhus masquerading as acute pancreatitis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 22 δευτερόλεπτα
The clinical spectrum of scrub typhus ranges from mild to fatal depending on the virulence of bacterial strain, susceptibility of the host and promptness with which treatment is started. We report a case of a 14-year-old child with scrub typhus who developed acute pancreatitis. On serological confirmation, doxycycline therapy was started. The patient responded well […]
Cleft sidedness and congenitally missing teeth in patients with cleft lip and palate patients
The aim of this study was to investigate the prevalence of cleft sidedness, and the number of congenitally missing teeth in regard to cleft type and gender. from #Dental via xlomafota13 on Inoreader http://ift.tt/1OaSFKe via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
On the Brink of Breakthroughs in Diagnosing and Treating Autism
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Science is taking a more personalized approach to treating the disorder and to understanding its diverse causes
Acoustic Absorption of Natural Fiber Composites
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
The current study is a bibliographic observation on prevailing tendencies in the development of acoustic absorption by natural fiber composites. Despite having less detrimental environmental effects and thorough availability, natural fibers are still unsuitable for wide implementation in industrial purposes. Some shortcomings such as the presence of moisture contents, thicker diameter, and lower antifungus quality […]
Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
This study was to investigate the antibiotic resistance profile of H. pylori and the distribution of CYP2C19 gene polymorphism in rural population of Chongqing, China. 214 and 111 strains of H. pylori were isolated from rural and urban patients, respectively. 99.53%, 20.09%, and 23.36% of the isolates in rural patients were found to be resistant […]
Blastocystis sp. Infection Mimicking Clostridium Difficile Colitis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
We report an unusual case of severe diarrhea related to Blastocystis sp. infection in a patient with end stage renal disease on hemodialysis. The patient was admitted due to profuse diarrhea associated with fever and leukocytosis. Pertinent stool work-up such as leukocytes in stool, stool culture, clostridium difficile toxin B PCR, and serology for hepatitis […]
Splinting of Longitudinal Fracture: An Innovative Approach
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Trauma may result in craze lines on the enamel surface, one or more fractured cusps of posterior teeth, cracked tooth syndrome, splitting of posterior teeth, and vertical fracture of root. Out of these, management of some fractures is of great challenge and such teeth are generally recommended for extraction. Literature search reveals attempts to manage […]
Histone Lysine Methylation in TGF-β1 Mediated p21 Gene Expression in Rat Mesangial Cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Transforming growth factor beta1- (TGF-β1-) induced p21-dependent mesangial cell (MC) hypertrophy plays a key role in the pathogenesis of chronic renal diseases including diabetic nephropathy (DN). Increasing evidence demonstrated the role of posttranscriptional modifications (PTMs) in the event; however, the precise regulatory mechanism of histone lysine methylation remains largely unknown. Here, we examined the roles […]
Selective Insulin Resistance in the Kidney
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Insulin resistance has been characterized as attenuation of insulin sensitivity at target organs and tissues, such as muscle and fat tissues and the liver. The insulin signaling cascade is divided into major pathways such as the PI3K/Akt pathway and the MAPK/MEK pathway. In insulin resistance, however, these pathways are not equally impaired. For example, in […]
Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas
[image: cover.gif?v=1&s=675d07de70e90879b0ebc822] Background Epigenetic modifications, including DNA methylation of tumor suppressor genes carried out by DNA methyltransferases (DNMTs), are important events in carcinogenesis. Although there are studies concerning to its expression in several cancer types, DNMTs expression pattern is not known in photoinduced lip carcinogenesis. The aim of this study was to investigate the immunoexpression of DNMTs 1, 3a, and 3b in lip precancerous lesion (actinic cheilitis) and cancer. Methods Thirty cases of actinic cheilitis (AC), thirty cases... περισσότερα »
Sensors, Vol. 16, Pages 659: A Precise Drunk Driving Detection Using Weighted Kernel Based on Electrocardiogram
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: ag] Globally, 1.2 million people die and 50 million people are injured annually due to traffic accidents. These traffic accidents cost $500 billion dollars. Drunk drivers are found in 40% of the traffic crashes. Existing drunk driving detection (DDD) systems do not provide accurate detection and pre-warning concurrently. Electrocardiogram (ECG) is a proven biosignal that accurately and simultaneously reflects human's biological status. In this letter, a classifier for DDD based on ECG is investigated in an attempt to reduce traffic accidents caused by drunk drivers. At this... περισσότερα »
Polymers, Vol. 8, Pages 185: Electro-Active Polymers (EAPs): A Promising Route to Design Bio-Organic/Bioinspired Platforms with on Demand Functionalities
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: ag] Through recent discoveries and new knowledge among correlations between molecular biology and materials science, it is a growing interest to design new biomaterials able to interact—i.e., to influence, to guide or to detect—with cells and their surrounding microenvironments, in order to better control biological phenomena. In this context, electro-active polymers (EAPs) are showing great promise as biomaterials acting as an interface between electronics and biology. This is ascribable to the highly tunability of chemical/physical properties which confer them different ... περισσότερα »
Materials, Vol. 9, Pages 351: Effect of Graphene Nanoplatelets on the Physical and Antimicrobial Properties of Biopolymer-Based Nanocomposites
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα
In this work, biopolymer-based nanocomposites with antimicrobial properties were prepared via melt-compounding. In particular, graphene nanoplatelets (GnPs) as fillers and an antibiotic, i.e., ciprofloxacin (CFX), as biocide were incorporated in a commercial biodegradable polymer blend of poly(lactic acid) (PLA) and a copolyester (BioFlex®). The prepared materials were characterized by scanning electron microscopy (SEM), and rheological and mechanical measurements. Moreover, the effect of GnPs on the antimicrobial properties and release kinetics of CFX was evaluated. The results i...περισσότερα »
Sensors, Vol. 16, Pages 658: Fluoride Anion Recognition by a Multifunctional Urea Derivative: An Experimental and Theoretical Study
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα
[image: ag] In this work we demonstrate the ability of a multifaceted N,N′-disubstituted urea to selectively recognize fluoride anion (F−) among other halides. This additional function is now added to its already reported organocatalytic and organogelator properties. The signaling mechanism relies on the formation of a charge-transfer (CT) complex between the urea-based sensor and F¯ in the ground state with a high association constant as demonstrated by absorption and fluorescence spectroscopy. The nature of the hydrogen bonding interaction between the sensor and F¯ was establish...περισσότερα »
Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses
[image: cover.gif?v=1&s=da614e72e3219d8335c602a9] Intestinal macrophages (IMs) are uniquely programmed to tolerate exposure to bacteria without mounting potent inflammatory responses. The cytokine IL-10 maintains the macrophage anti-inflammatory response such that loss of IL-10 results in chronic intestinal inflammation. To investigate how IL-10-deficiency alters IM programming and bacterial tolerance, we studied changes in chromatin accessibility in response to bacteria in macrophages from two distinct niches, the intestine and bone-marrow, from both wild-type and IL-10-deficient... περισσότερα »
Activation-dependent cell death of human monocytes is a novel mechanism of fine-tuning inflammation and autoimmunity
[image: cover.gif?v=1&s=da614e72e3219d8335c602a9] In patients with juvenile idiopathic arthritis (JIA), increased release of IFN-γ and GM-CSF in cells infiltrating synovial tissue can be a potent driver of monocyte activation. Given the fundamental role of monocyte activation in remodeling the early phases of inflammatory responses, here we analyze the GM-CSF/IFN-γ-induced activity of human monocytes in such a situation in vitro and in vivo. Monocytes from healthy donors were isolated and stimulated with GM-CSF±IFN-γ. Monocyte activation and death were analyzed by flow cytometry, ...περισσότερα »
Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses
[image: cover.gif?v=1&s=da614e72e3219d8335c602a9] Intestinal macrophages (IMs) are uniquely programmed to tolerate exposure to bacteria without mounting potent inflammatory responses. The cytokine IL-10 maintains the macrophage anti-inflammatory response such that loss of IL-10 results in chronic intestinal inflammation. To investigate how IL-10-deficiency alters IM programming and bacterial tolerance, we studied changes in chromatin accessibility in response to bacteria in macrophages from two distinct niches, the intestine and bone-marrow, from both wild-type and IL-10-deficient... περισσότερα »
Activation-dependent cell death of human monocytes is a novel mechanism of fine-tuning inflammation and autoimmunity
[image: cover.gif?v=1&s=da614e72e3219d8335c602a9] In patients with juvenile idiopathic arthritis (JIA), increased release of IFN-γ and GM-CSF in cells infiltrating synovial tissue can be a potent driver of monocyte activation. Given the fundamental role of monocyte activation in remodeling the early phases of inflammatory responses, here we analyze the GM-CSF/IFN-γ-induced activity of human monocytes in such a situation in vitro and in vivo. Monocytes from healthy donors were isolated and stimulated with GM-CSF±IFN-γ. Monocyte activation and death were analyzed by flow cytometry, ...περισσότερα »
PulmCrit- Fentanyl infusions for sedation: The opioid pendulum swings astray?
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: pendulum.gif?resize=750%2C366] I've been using fentanyl infusions as the backbone of my sedative strategy, in keeping with the 2013 SCCM guidelines. This generally works well for patients who can be extubated quickly. However, for patients who remain on the ventilator for longer periods of time, it often leads to problems involving tolerance and withdrawal. EMCrit by Josh Farkas. from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1SYi0qW via IFTTT
Molecules, Vol. 21, Pages 604: Protective Effects of Dihydromyricetin against •OH-Induced Mesenchymal Stem Cells Damage and Mechanistic Chemistry
[image: ag] As a natural flavonoid in Ampelopsis grossedentata, dihydromyricetin (DHM, 2R,3R-3,5,7,3′,4′,5′-hexahydroxy-2,3-dihydroflavonol) was observed to increase the viability of •OH-treated mesenchymal stem cells using a MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl] assay and flow cytometry analysis. This protective effect indicates DHM may be a beneficial agent for cell transplantation therapy. Mechanistic chemistry studies indicated that compared with myricetin, DHM was less effective at ABTS+• (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid radical) scavenging and...περισσότερα »
Sensors, Vol. 16, Pages 660: Investigation of Hemoglobin/Gold Nanoparticle Heterolayer on Micro-Gap for Electrochemical Biosensor Application
In the present study, we fabricated a hemoglobin/gold nanoparticle (Hb/GNP) heterolayer immobilized on the Au micro-gap to confirm H2O2 detection with a signal-enhancement effect. The hemoglobin which contained the heme group catalyzed the reduction of H2O2. To facilitate the electron transfer between hemoglobin and Au micro-gap electrode, a gold nanoparticle was introduced. The Au micro-gap electrode that has gap size of 5 µm was fabricated by conventional photolithographic technique to locate working and counter electrodes oppositely in a single chip for the signal sensitivity a... περισσότερα »
Sustainability, Vol. 8, Pages 457: Study on the Evolvement of Technology Development and Energy Efficiency—A Case Study of the Past 30 Years of Development in Shanghai
Previous research in regional energy efficiency by using macro statistical data has demonstrated that technology development could improve regional energy efficiency. Since the start of reform and opening up in 1978, China has mainly adopted energy import and foreign direct investment to promote economic growth. At the same time, the country has also increased the input of technology and R&D to prompt technological reformation and imported technology absorption. However, there is limited research on the relationship between technology development and energy efficiency. Using the g...περισσότερα »
Organic matter in upper Albian marine sediments in the High-Tatric units, central western Carpathians related to Oceani c Anoxic Event 1d—Geochemistry, microfacies and palynology
Publication date: 15 July 2016 Source:Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 454 Author(s): Krzysztof Bąk, Monika Fabiańska, Marta Bąk, Magdalena Misz-Kennan, Magdalena Zielińska, Paweł Dulemba, Tomasz Bryndal, Beata Naglik A multidisciplinary study of upper Albian hemipelagic sediments related to the Oceanic Anoxic Event 1d (OAE1d) from the High-Tatric units (central western Carpathians, Polish part of the Tatra… Continue reading Organic matter in upper Albian marine sediments in the High-Tatric units, central western Carpathians related to Oceani c Anoxic Event ... περισσότερα »
Strange seaweed rewrites history of green plants
Ancient alga developed large size and complex structure independently of other plants. Nature News doi: 10.1038/nature.2016.19863 from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1OjV6VE via IFTTT
Nutrients, Vol. 8, Pages 276: Sesamin Ameliorates High-Fat Diet–Induced Dyslipidemia and Kidney Injury by Reducing Oxidative Stress
The study explored the protective effect of sesamin against lipid-induced renal injury and hyperlipidemia in a rat model. An animal model of hyperlipidemia was established in Sprague-Dawley rats. Fifty-five adult Sprague-Dawley rats were divided into five groups. The control group was fed a standard diet, while the other four groups were fed a high-fat diet for 5 weeks to induce hyperlipidemia. Three groups received oral sesamin in doses of 40, 80, or 160 mg/(kg·day). Seven weeks later, the blood lipids, renal function, antioxidant enzyme activities, and hyperoxide levels in kidne... περισσότερα »
Comparison of centring ability and transportation between four nickel titanium instrumentation techniques by micro-computed tomography (μCT)
Abstract Aim To compare the centring ability and transportation of ProTaper Next (PTN), ProTaper Universal (PTU), Race 123 and Revo S using micro computed tomography (μCT). Methodology Sixty mesial root canals of thirty mandibular molars were divided virtually into coronal, middle and apical thirds and two reproducible reference points were marked on the external surface of the roots creating 360 measurement points. Samples were randomly allocated to four NiTi instrumentation techniques. Group 1: PTU up to F2 (n=16), group 2: PTN up to X2 (n=18), group 3: Race 123 up to T2 (n=12... περισσότερα »
Retrograde root canal treatment: A prospective case series
Abstract Aim Root canal treatment of teeth with necrotic pulps and apical periodontitis may be complicated by limited access to the root canals due to restorations and dystrophic calcifications. The objective of this study was to evaluate retrograde root canal as a primary treatment using a surgical approach as an alternative to conventional orthograde treatment. Methodology Patients with apical periodontitis in the anterior region of the maxilla were consecutively recruited to the study over a period of 4 years. Fifty-Seven patients met the inclusion criteria and received retrog... περισσότερα »
Nutrients, Vol. 8, Pages 276: Sesamin Ameliorates High-Fat Diet–Induced Dyslipidemia and Kidney Injury by Reducing Oxidative Stress
The study explored the protective effect of sesamin against lipid-induced renal injury and hyperlipidemia in a rat model. An animal model of hyperlipidemia was established in Sprague-Dawley rats. Fifty-five adult Sprague-Dawley rats were divided into five groups. The control group was fed a standard diet, while the other four groups were fed a high-fat diet for 5 weeks to induce hyperlipidemia. Three groups received oral sesamin in doses of 40, 80, or 160 mg/(kg·day). Seven weeks later, the blood lipids, renal function, antioxidant enzyme activities, and hyperoxide levels in kidne... περισσότερα »
Symmetry, Vol. 8, Pages 33: Multivariate Krawtchouk Polynomials and Composition Birth and Death Processes
This paper defines the multivariate Krawtchouk polynomials, orthogonal on the multinomial distribution, and summarizes their properties as a review. The multivariate Krawtchouk polynomials are symmetric functions of orthogonal sets of functions defined on each of N multinomial trials. The dual multivariate Krawtchouk polynomials, which also have a polynomial structure, are seen to occur naturally as spectral orthogonal polynomials in a Karlin and McGregor spectral representation of transition functions in a composition birth and death process. In this Markov composition process in...περισσότερα »
Average UK family can’t afford cancer warns Macmillan
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The average family in the UK would not be able to afford cancer, and could be forced to find hundreds of pounds a month if they were hit by the disease, according to new analysis released today by Macmillan Cancer Support. Macmillan calculates that the… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/276YoH6 via IFTTT
Study suggests testosterone therapy does not raise risk of aggressive prostate cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Men with low levels of the male sex hormone testosterone need not fear that testosterone replacement therapy will increase their risk of prostate cancer. This is the finding of an analysis of more than a quarter-million medical records of mostly white… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1T0m6eI via IFTTT
IJERPH, Vol. 13, Pages 479: Hospitalisation Resulting from Medicine-Related Problems in Adult Patients with Cardiovascular Diseases and Diabetes in the United Kingdom and Saudi Arabia
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Cardiovascular diseases (CVDs) and diabetes (DM) are two interrelated conditions that have a heavy morbidity and mortality burden worldwide. Patients with the two conditions usually take multiple medicines and thus are more susceptible to medicine-related problems (MRPs). MRPs can occur at any stage of the treatment process and in many cases can lead to unplanned […]
Assessing Bowel Cleansing for Colonoscopy: Changing Our Focus to What Really Matters
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Zw3jff via IFTTT
Differences in Cortical Representation and Structural Connectivity of Hands and Feet between Professional Handball Players and Ballet Dancers
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
It is known that intensive training and expertise are associated with functional and structural neuroadaptations. Most studies, however, compared experts with nonexperts; hence it is, specifically for sports, unclear whether the neuroplastic adaptations reported are sport-specific or sport-general. Here we aimed at investigating sport-specific adaptations in professional handball players and ballet dancers by focusing on […]
Diversity of Virulence Factors Associated with West Australian Methicillin-Sensitive Staphylococcus aureus Isolates of Human Origin
An extensive array of virulence factors associated with S. aureus has contributed significantly to its success as a major nosocomial pathogen in hospitals and community causing variety of infections in affected patients. Virulence factors include immune evading capsular polysaccharides, poly-N-acetyl glucosamine, and teichoic acid in addition to damaging toxins including hemolytic toxins, enterotoxins, cytotoxins, exfoliative toxin, and microbial surface components recognizing adhesive matrix molecules (MSCRAMM). In this investigation, 31 West Australian S. aureus isolates of huma...περισσότερα »
Mutation Analysis of the Common Deafness Genes in Patients with Nonsyndromic Hearing Loss in Linyi by SNPscan Assay
Hearing loss is a common sensory disorder, and at least 50% of cases are due to a genetic etiology. Although hundreds of genes have been reported to be associated with nonsyndromic hearing loss, GJB2, SLC26A4, and mtDNA12SrRNA are the major contributors. However, the mutation spectrum of these common deafness genes varies among different ethnic groups. The present work summarized mutations in these three genes and their prevalence in 339 patients with nonsyndromic hearing loss at three different special education schools and one children's hospital in Linyi, China. A new multiplex...περισσότερα »
IJERPH, Vol. 13, Pages 479: Hospitalisation Resulting from Medicine-Related Problems in Adult Patients with Cardiovascular Diseases and Diabetes in the United Kingdom and Saudi Arabia
Cardiovascular diseases (CVDs) and diabetes (DM) are two interrelated conditions that have a heavy morbidity and mortality burden worldwide. Patients with the two conditions usually take multiple medicines and thus are more susceptible to medicine-related problems (MRPs). MRPs can occur at any stage of the treatment process and in many cases can lead to unplanned hospitalisations. The aim of the study was to determine the prevalence of hospitalisation resulting from MRPs in adult patients with CVDs and/or DM and to identify the main causes, risk factors, and medicine classes invol...περισσότερα »
Nutrients, Vol. 8, Pages 275: The Potential Protective Effects of Polyphenols in Asbestos-Mediated Inflammation and Carcinogenesis of Mesothelium
Malignant Mesothelioma (MM) is a tumor of the serous membranes linked to exposure to asbestos. A chronic inflammatory response orchestrated by mesothelial cells contributes to the development and progression of MM. The evidence that: (a) multiple signaling pathways are aberrantly activated in MM cells; (b) asbestos mediated-chronic inflammation has a key role in MM carcinogenesis; (c) the deregulation of the immune system might favor the development of MM; and (d) a drug might have a better efficacy when injected into a serous cavity thus bypassing biotransformation and reaching a... περισσότερα »
Immobilization of Genetically-Modified d-Amino Acid Oxidase and Catalase on Carbon Nanotubes to Improve the Catalytic Efficiency
[image: ag] d-amino acid oxidase (DAAO) and catalase (CAT) have been genetically modified by fusing them to an elastin-like polypeptide (ELP). ELP-DAAO and ELP-CAT have been separately immobilized on multi-walled carbon nanotubes (MWNTs). It has been found that the secondary structures of the enzymes have been preserved. ELP-DAAO catalyzed the oxidative deamination of d-alanine, and H2O2 was evolved continuously. When the MWNT-supported enzymes were used together, the generated hydrogen peroxide of ELP-DAAO could be decomposed in situ. The catalytic efficiency of the two immobiliz... περισσότερα »
Molecules, Vol. 21, Pages 581: Supported Pd-Au Membrane Reactor for Hydrogen Production: Membrane Preparation, Characterization and Testing
A supported Pd-Au (Au 7wt%) membrane was produced by electroless plating deposition. Permeation tests were performed with pure gas (H2, H2, N2, CO2, CH4) for long time operation. After around 400 h under testing, the composite Pd-Au membrane achieved steady state condition, with an H2/N2 ideal selectivity of around 500 at 420 °C and 50 kPa as transmembrane pressure, remaining stable up to 1100 h under operation. Afterwards, the membrane was allocated in a membrane reactor module for methane steam reforming reaction tests. As a preliminary application, at 420 °C, 300 kPa of reactio... περισσότερα »
Molecules, Vol. 21, Pages 603: High-Performance Liquid Chromatography with Diode Array Detector and Electrospray Ionization Ion Trap Time-of-Flight Tandem Mass Spectrometry to Evaluate Ginseng Roots and Rhizomes from Different Regions
Ginseng, Panax ginseng C. A. Meyer, is an industrial crop in China and Korea. The functional components in ginseng roots and rhizomes are characteristic ginsenosides. This work developed a new high-performance liquid chromatography coupled with electrospray ionization ion trap time-of-flight multistage mass spectrometry (LC–ESI-IT-TOF-MSn) method to identify the triterpenoids. Sixty compounds (1–60) including 58 triterpenoids were identified from the ginseng cultivated in China. Substances 1, 2, 7, 15–20, 35, 39, 45–47, 49, 55–57, 59, and 60 were identified for the first time. To ... περισσότερα »
Nanomaterials, Vol. 6, Pages 87: Rapamycin Loaded Solid Lipid Nanoparticles as a New Tool to Deliver mTOR Inhibitors: Formulation and in Vitro Characterization
Recently, the use of mammalian target of rapamycin (mTOR) inhibitors, in particular rapamycin (Rp), has been suggested to improve the treatment of neurodegenerative diseases. However, as Rp is a strong immunosuppressant, specific delivery to the brain has been postulated to avoid systemic exposure. In this work, we fabricated new Rp loaded solid lipid nanoparticles (Rp-SLN) stabilized with polysorbate 80 (PS80), comparing two different methods and lipids. The formulations were characterized by differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), wide angle X-...περισσότερα »
IJERPH, Vol. 13, Pages 478: Estimating Nitrogen Load Resulting from Biofuel Mandates
The Energy Policy Act of 2005 and the Energy Independence and Security Act (EISA) of 2007 were enacted to reduce the U.S. dependency on foreign oil by increasing the use of biofuels. The increased demand for biofuels from corn and soybeans could result in an increase of nitrogen flux if not managed properly. The objectives of this study are to estimate nitrogen flux from energy crop production and to identify the catchment areas with high nitrogen flux. The results show that biofuel production can result in an increase of nitrogen flux to the northern Gulf of Mexico from 270 to 174... περισσότερα »
The role of chemerin and ChemR23 in stimulating the invasion of squamous oesophageal cancer cells
British Journal of Cancer from #Medicine via ola Kala on Inoreader http://ift.tt/24FChJ7 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Serum interleukin (IL)-9 and IL-10, but not T-helper 9 (Th9) cells, are associated with survival of patients with acute-on-chronic hepatitis B liver failure
Medicine from #Medicine via ola Kala on Inoreader http://ift.tt/1rJvgFp Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Severe acute hepatocellular injury attributed to OxyELITE Pro: A case series
Digestive Diseases and Sciences from #Medicine via ola Kala on Inoreader http://ift.tt/24FCfRF Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The risk of community-acquired pneumonia among 9803 patients with coeliac disease compared to the general population: a cohort study
Alimentary Pharmacology and Therapeutics from #Medicine via ola Kala on Inoreader http://ift.tt/1rJvgFf Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Effect of a Financial Incentive for Colorectal Cancer Screening Adherence on the Appropriateness of Colonoscopy Orders
American Journal of Medical Quality from #Medicine via ola Kala on Inoreader http://ift.tt/24FChsM Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Impact of hypocaloric hyperproteic diet on gut microbiota in overweight or obese patients with nonalcoholic fatty liver disease: A pilot study
Digestive Diseases and Sciences from #Medicine via ola Kala on Inoreader http://ift.tt/1rJvjkv Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
French national consensus clinical guidelines for the management of ulcerative colitis
Digestive and Liver Diseases from #Medicine via ola Kala on Inoreader http://ift.tt/24FCfRz Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The role of combined 24-h multichannel intraluminal impedance-pH monitoring in the evaluation of children with gastrointestinal symptoms suggesting gastro-esophageal reflux disease
Neurogastroenterology & Motility from #Medicine via ola Kala on Inoreader http://ift.tt/1rJvjkp Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Insufficient evidence of benefit regarding mortality due to albumin substitution in HCC-free cirrhotic patients undergoing large volume paracentesis.
Journal of Gastroenterology and Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/24FCfBh Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Development and validation of a radiomics nomogram for preoperative prediction of lymph node metastasis in colorectal cancer
Journal of Clinical Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/1rJvgoM Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Most premature surveillance colonoscopy is not attributable to bowel preparation or new clinical indications
Digestive Diseases and Sciences from #Medicine via ola Kala on Inoreader http://ift.tt/24FCfBa Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Treatment allocation in patients with early-stage esophageal adenocarcinoma: Prevalence and predictors of lymph node involvement
Cancer from #Medicine via ola Kala on Inoreader http://ift.tt/1rJvdtl Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Magnetic resonance enterography changes after antibody to tumor necrosis factor (anti-TNF) alpha therapy in Crohn’s disease: correlation with SES-CD and clinical-biological markers
BMC Medical Imaging from #Medicine via ola Kala on Inoreader http://ift.tt/24FCfB2 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Patient-Reported Outcomes Measurement Information System in children with Crohn's disease
The Journal of Pediatrics from #Medicine via ola Kala on Inoreader http://ift.tt/1rJvj3W Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Diversity of Virulence Factors Associated with West Australian Methicillin-Sensitive Staphylococcus aureus Isolates of Human Origin
An extensive array of virulence factors associated with S. aureus has contributed significantly to its success as a major nosocomial pathogen in hospitals and community causing variety of infections in affected patients. Virulence factors include immune evading capsular polysaccharides, poly-N-acetyl glucosamine, and teichoic acid in addition to damaging toxins including hemolytic toxins, enterotoxins, cytotoxins, exfoliative toxin, and microbial surface components recognizing adhesive matrix molecules (MSCRAMM). In this investigation, 31 West Australian S. aureus isolates of huma...περισσότερα »
Mutation Analysis of the Common Deafness Genes in Patients with Nonsyndromic Hearing Loss in Linyi by SNPscan Assay
Hearing loss is a common sensory disorder, and at least 50% of cases are due to a genetic etiology. Although hundreds of genes have been reported to be associated with nonsyndromic hearing loss, GJB2, SLC26A4, and mtDNA12SrRNA are the major contributors. However, the mutation spectrum of these common deafness genes varies among different ethnic groups. The present work summarized mutations in these three genes and their prevalence in 339 patients with nonsyndromic hearing loss at three different special education schools and one children's hospital in Linyi, China. A new multiplex...περισσότερα »
IJERPH, Vol. 13, Pages 479: Hospitalisation Resulting from Medicine-Related Problems in Adult Patients with Cardiovascular Diseases and Diabetes in the United Kingdom and Saudi Arabia
Cardiovascular diseases (CVDs) and diabetes (DM) are two interrelated conditions that have a heavy morbidity and mortality burden worldwide. Patients with the two conditions usually take multiple medicines and thus are more susceptible to medicine-related problems (MRPs). MRPs can occur at any stage of the treatment process and in many cases can lead to unplanned hospitalisations. The aim of the study was to determine the prevalence of hospitalisation resulting from MRPs in adult patients with CVDs and/or DM and to identify the main causes, risk factors, and medicine classes invol...περισσότερα »
Diversity of Virulence Factors Associated with West Australian Methicillin-Sensitive Staphylococcus aureus Isolates of Human Origin
An extensive array of virulence factors associated with S. aureus has contributed significantly to its success as a major nosocomial pathogen in hospitals and community causing variety of infections in affected patients. Virulence factors include immune evading capsular polysaccharides, poly-N-acetyl glucosamine, and teichoic acid in addition to damaging toxins including hemolytic toxins, enterotoxins, cytotoxins, exfoliative toxin, and microbial surface components recognizing adhesive matrix molecules (MSCRAMM). In this investigation, 31 West Australian S. aureus isolates of huma...περισσότερα »
Mutation Analysis of the Common Deafness Genes in Patients with Nonsyndromic Hearing Loss in Linyi by SNPscan Assay
Hearing loss is a common sensory disorder, and at least 50% of cases are due to a genetic etiology. Although hundreds of genes have been reported to be associated with nonsyndromic hearing loss, GJB2, SLC26A4, and mtDNA12SrRNA are the major contributors. However, the mutation spectrum of these common deafness genes varies among different ethnic groups. The present work summarized mutations in these three genes and their prevalence in 339 patients with nonsyndromic hearing loss at three different special education schools and one children's hospital in Linyi, China. A new multiplex...περισσότερα »
IJERPH, Vol. 13, Pages 479: Hospitalisation Resulting from Medicine-Related Problems in Adult Patients with Cardiovascular Diseases and Diabetes in the United Kingdom and Saudi Arabia
Cardiovascular diseases (CVDs) and diabetes (DM) are two interrelated conditions that have a heavy morbidity and mortality burden worldwide. Patients with the two conditions usually take multiple medicines and thus are more susceptible to medicine-related problems (MRPs). MRPs can occur at any stage of the treatment process and in many cases can lead to unplanned hospitalisations. The aim of the study was to determine the prevalence of hospitalisation resulting from MRPs in adult patients with CVDs and/or DM and to identify the main causes, risk factors, and medicine classes invol...περισσότερα »
Diversity of Virulence Factors Associated with West Australian Methicillin-Sensitive Staphylococcus aureus Isolates of Human Origin
An extensive array of virulence factors associated with S. aureus has contributed significantly to its success as a major nosocomial pathogen in hospitals and community causing variety of infections in affected patients. Virulence factors include immune evading capsular polysaccharides, poly-N-acetyl glucosamine, and teichoic acid in addition to damaging toxins including hemolytic toxins, enterotoxins, cytotoxins, exfoliative toxin, and microbial surface components recognizing adhesive matrix molecules (MSCRAMM). In this investigation, 31 West Australian S. aureus isolates of huma...περισσότερα »
Mutation Analysis of the Common Deafness Genes in Patients with Nonsyndromic Hearing Loss in Linyi by SNPscan Assay
Hearing loss is a common sensory disorder, and at least 50% of cases are due to a genetic etiology. Although hundreds of genes have been reported to be associated with nonsyndromic hearing loss, GJB2, SLC26A4, and mtDNA12SrRNA are the major contributors. However, the mutation spectrum of these common deafness genes varies among different ethnic groups. The present work summarized mutations in these three genes and their prevalence in 339 patients with nonsyndromic hearing loss at three different special education schools and one children's hospital in Linyi, China. A new multiplex...περισσότερα »
Formation of a stable radical by oxidation of a tetraorganoborate
[image: GA?id=C6CC02916G] *Chem. Commun.*, 2016, Advance Article *DOI*: 10.1039/C6CC02916G, Communication Holger Braunschweig, Ivo Krummenacher, Lisa Mailander, Leanne Pentecost, Alfredo Vargas Oxidation of a tetraorganoborate salt leads to selective formation of the corresponding zwitterionic radical rather than carbon-carbon bond formation of the boron substituents. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1... περισσότερα »
Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice
Summary There is a continuous drive to find new, improved therapies that have a different mechanism of action in order to help diminish the sizable percentage of persons with pharmacoresistant epilepsy. Uric acid is increasingly recognized as contributing to the pathophysiology of multiple disorders, and there are indications that uric acid might play a role in epileptic mechanisms. Nevertheless, studies that directly investigate its involvement are lacking. In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with geneticall... περισσότερα »
A study of speaker clustering for speaker attribution in large telephone conversation datasets
[image: S08852308.gif] Publication date: Available online 9 May 2016 *Source:*Computer Speech & Language Author(s): Houman Ghaemmaghami, David Dean, Sridha Sridharan, David A. van Leeuwen This paper proposes the task of speaker attribution as speaker diarization followed by speaker linking. The aim of attribution is to identify and label common speakers across multiple recordings. To do this, it is necessary to first carry out diarization to obtain speaker-homogeneous segments from each recording. Speaker linking can then be conducted to link common speaker identities across multipl...περισσότερα »
Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice
Summary There is a continuous drive to find new, improved therapies that have a different mechanism of action in order to help diminish the sizable percentage of persons with pharmacoresistant epilepsy. Uric acid is increasingly recognized as contributing to the pathophysiology of multiple disorders, and there are indications that uric acid might play a role in epileptic mechanisms. Nevertheless, studies that directly investigate its involvement are lacking. In this study we assessed the susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice with genetically... περισσότερα »
A study of speaker clustering for speaker attribution in large telephone conversation datasets
[image: S08852308.gif] Publication date: Available online 9 May 2016 *Source:*Computer Speech & Language Author(s): Houman Ghaemmaghami, David Dean, Sridha Sridharan, David A. van Leeuwen This paper proposes the task of speaker attribution as speaker diarization followed by speaker linking. The aim of attribution is to identify and label common speakers across multiple recordings. To do this, it is necessary to first carry out diarization to obtain speaker-homogeneous segments from each recording. Speaker linking can then be conducted to link common speaker identities across multipl...περισσότερα »
Decentralized Optimization for a Novel Control Structure of HVAC System
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
A decentralized control structure is introduced into the heating, ventilation, and air conditioning (HVAC) system to solve the high maintenance and labor cost problem in actual engineering. Based on this new control system, a decentralized optimization method is presented for sensor fault repair and optimal group control of HVAC equipment. Convergence property of the novel […]
Diversity of Virulence Factors Associated with West Australian Methicillin-Sensitive Staphylococcus aureus Isolates of Human Origin
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
An extensive array of virulence factors associated with S. aureus has contributed significantly to its success as a major nosocomial pathogen in hospitals and community causing variety of infections in affected patients. Virulence factors include immune evading capsular polysaccharides, poly-N-acetyl glucosamine, and teichoic acid in addition to damaging toxins including hemolytic toxins, enterotoxins, cytotoxins, exfoliative […]
Mutation Analysis of the Common Deafness Genes in Patients with Nonsyndromic Hearing Loss in Linyi by SNPscan Assay
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Hearing loss is a common sensory disorder, and at least 50% of cases are due to a genetic etiology. Although hundreds of genes have been reported to be associated with nonsyndromic hearing loss, GJB2, SLC26A4, and mtDNA12SrRNA are the major contributors. However, the mutation spectrum of these common deafness genes varies among different ethnic groups. […]
The Reliability of a Novel Automated System for ANA Immunofluorescence Analysis in Daily Clinical Practice
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Automated interpretation (AI) systems for antinuclear antibody (ANA) analysis have been introduced based on assessment of indirect immunofluorescence (IIF) patterns. The diagnostic performance of a novel automated IIF reading system was compared with visual interpretation (VI) of IIF in daily clinical practice to evaluate the reduction of workload. ANA-IIF tests of consecutive serum samples from […]
Treatment Outcomes of Tuberculosis and Associated Factors in an Ethiopian University Hospital
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Background. Tuberculosis remains a major global health problem. It causes ill-health among millions of people each year and ranks alongside the human immunodeficiency virus (HIV) as a leading cause of death worldwide. Purpose. To assess the outcome of tuberculosis treatment and to identify factors associated with tuberculosis treatment outcome. Methods. A five-year retrospective cross-sectional study […]
Nutrients, Vol. 8, Pages 275: The Potential Protective Effects of Polyphenols in Asbestos-Mediated Inflammation and Carcinogenesis of Mesothelium
Malignant Mesothelioma (MM) is a tumor of the serous membranes linked to exposure to asbestos. A chronic inflammatory response orchestrated by mesothelial cells contributes to the development and progression of MM. The evidence that: (a) multiple signaling pathways are aberrantly activated in MM cells; (b) asbestos mediated-chronic inflammation has a key role in MM carcinogenesis; (c) the deregulation of the immune system might favor the development of MM; and (d) a drug might have a better efficacy when injected into a serous cavity thus bypassing biotransformation and reaching a... περισσότερα »
Sustainability, Vol. 8, Pages 456: Transformational and Transactional Factors for the Successful Implementation of Enterprise Architecture in Public Sector
Enterprise architecture (EA) is one of the most important and effective tools for delivering high-quality e-government services to citizens. In this study, we used organizational performance and change theory to determine factors that contribute to the successful implementation of EA. We classified these factors as one of two types: transformation change (TFC) and transactional change (TSC). To identify these factors, we collected survey data from Korean public sectors that have implemented EA for years. Results show that while EA management systems (EAMS) and EA guidelines direct...περισσότερα »
Catalysts, Vol. 6, Pages 66: Immobilization of Genetically-Modified d-Amino Acid Oxidase and Catalase on Carbon Nanotubes to Improve the Catalytic Efficiency
d-amino acid oxidase (DAAO) and catalase (CAT) have been genetically modified by fusing them to an elastin-like polypeptide (ELP). ELP-DAAO and ELP-CAT have been separately immobilized on multi-walled carbon nanotubes (MWNTs). It has been found that the secondary structures of the enzymes have been preserved. ELP-DAAO catalyzed the oxidative deamination of d-alanine, and H2O2 was evolved continuously. When the MWNT-supported enzymes were used together, the generated hydrogen peroxide of ELP-DAAO could be decomposed in situ. The catalytic efficiency of the two immobilized enzymes w... περισσότερα »
Molecules, Vol. 21, Pages 581: Supported Pd-Au Membrane Reactor for Hydrogen Production: Membrane Preparation, Characterization and Testing
A supported Pd-Au (Au 7wt%) membrane was produced by electroless plating deposition. Permeation tests were performed with pure gas (H2, H2, N2, CO2, CH4) for long time operation. After around 400 h under testing, the composite Pd-Au membrane achieved steady state condition, with an H2/N2 ideal selectivity of around 500 at 420 °C and 50 kPa as transmembrane pressure, remaining stable up to 1100 h under operation. Afterwards, the membrane was allocated in a membrane reactor module for methane steam reforming reaction tests. As a preliminary application, at 420 °C, 300 kPa of reactio... περισσότερα »
Nutrients, Vol. 8, Pages 275: The Potential Protective Effects of Polyphenols in Asbestos-Mediated Inflammation and Carcinogenesis of Mesothelium
Malignant Mesothelioma (MM) is a tumor of the serous membranes linked to exposure to asbestos. A chronic inflammatory response orchestrated by mesothelial cells contributes to the development and progression of MM. The evidence that: (a) multiple signaling pathways are aberrantly activated in MM cells; (b) asbestos mediated-chronic inflammation has a key role in MM carcinogenesis; (c) the deregulation of the immune system might favor the development of MM; and (d) a drug might have a better efficacy when injected into a serous cavity thus bypassing biotransformation and reaching a... περισσότερα »
