Acute Severe Hypercalcemia After Traumatic Fractures and Immobilization in Hypophosphatasia Complicated by Chronic Renal Failure
Acute Severe Hypercalcemia After Traumatic Fractures and Immobilization in Hypophosphatasia Complicated by Chronic Renal Failure: Context: Hypophosphatasia (HPP) features deficient activity of the "tissue-nonspecific" isoenzyme of alkaline phosphatase (TNSALP) due to loss-of-function mutation(s) within the *TNSALP* gene. Consequently, inorganic pyrophosphate, a TNSALP substrate and inhibitor of mineralization, accumulates extracellularly. This can cause rickets or osteomalacia. Objective: We report a 55-year-old man with HPP and chronic renal failure (CRF) requiring hemodialysis w...περισσότερα »
Coexistence of Malignant Struma Ovarii and Cervical Papillary Thyroid Carcinoma
Coexistence of Malignant Struma Ovarii and Cervical Papillary Thyroid Carcinoma: Context: Struma ovarii is an uncommon monodermal teratoma in which thyroid tissue is the predominant element. Malignant transformation of struma ovarii is an even rarer occurrence. Case Presentation: We describe a 42-year-old woman who underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy for a symptomatic left pelvic mass. Histology revealed malignant struma ovarii with classical papillary thyroid carcinoma expression. Ultrasonography of the cervical neck showed thyroid microno...περισσότερα »
Iodine nutritional status
Iodine nutritional status in Uttarakhand State, India: *Neha Sareen, Umesh Kapil, Vanisha Nambiar, Ravindra Mohan Pandey, Preetika Khenduja* Indian Journal of Endocrinology and Metabolism 2016 20(2):171-176 Introduction: Uttarakhand (UK) state is a known endemic region to iodine deficiency (ID). Objective: To assess the current status of iodine nutrition in a population of UK. Methodology: Three districts, namely Udham Singh Nagar (USN), Nainital (N), and Pauri Garhwal (PG) were selected. In each district, 30 clusters were identified by utilizing the population proportional to s... περισσότερα »
Evaluation of maternal thyroid function
Reference intervals in evaluation of maternal thyroid function of Manipuri women: *Felix K Jebasingh, Ranabir Salam, Trinity Laishram Meetei, Premchand Thangjam Singh, Nabakishore Naorem Singh, Lallan Prasad* Indian Journal of Endocrinology and Metabolism 2016 20(2):167-170 Context: The population of Manipur is of different ethnic background from the rest of the country. Several authors have suggested population/ethnic and laboratory specific reference range of maternal thyroid profile of different trimesters. Aims: To find the reference range of thyroid stimulating hormone (TSH... περισσότερα »
Effect of steroid replacement on thyroid function and thyroid autoimmunity in Addison' s disease with primary hypothyroidism
Effect of steroid replacement on thyroid function and thyroid autoimmunity in Addison' s disease with primary hypothyroidism: *Jaya Prakash Sahoo, Jayakumar Selviambigapathy, Sadishkumar Kamalanathan, K Nagarajan, Muthupillai Vivekanandan* Indian Journal of Endocrinology and Metabolism 2016 20(2):162-166 Background: Steroid replacement without thyroxine supplementation normalizes thyroid function test (TFT) in some but not all Addison's disease patients with primary hypothyroidism. Both autoimmune and nonautoimmune mechanisms contribute to this improvement in TFT. However, the ... περισσότερα »
Technetium uptake predicts remission and relapse in Grave's disease patients on antithyroid drugs
Technetium uptake predicts remission and relapse in Grave's disease patients on antithyroid drugs for at least 1 year in South Indian subjects: *Neha Singhal, VP Praveen, Nisha Bhavani, Arun S Menon, Usha Menon, Nithya Abraham, Harish Kumar, RV JayKumar, Vasantha Nair, Shanmugha Sundaram, Padma Sundaram* Indian Journal of Endocrinology and Metabolism 2016 20(2):157-161 Context: Most of the information on remission related factors in Grave's disease are derived from Western literature. It is likely that there may be additional prognostic factors and differences in the postdrug tr...περισσότερα »
Hyponatremia, the most common electrolyte disorder in hospitalized patients is associated with increased risk of mortality even when mild and apparently asymptomatic
Vasopressin receptor antagonists: characteristics and clinical role via ScienceDirect Publication: Best Practice & Research Clinical Endocrinology & Metabolism Publication date: Available online 16 February 2016 *Source:*Best Practice & Research Clinical Endocrinology & Metabolism Author(s): Helbert Rondon-Berrios, Tomas Berl Hyponatremia, the most common electrolyte disorder in hospitalized patients is associated with increased risk of mortality even when mild and apparently asymptomatic. Likewise morbidity manifested as attention deficits, gait disturbances, falls, fractures, and oste... περισσότερα »
Toll-like Receptor 3 mediating virus-induced progression of pituitary adenomas
Evidence for possible role of via http://rss.sciencedirect.com/publication/science/03037207 Publication date: Available online 15 February 2016 *Source:*Molecular and Cellular Endocrinology Author(s): Xin Zheng, Song Li, Zhenle Zang, Jintao Hu, Jiayin An, Xiangdong Pei, Feng Zhu, Weihua Zhang, Hui Yang Tumor-related viruses are known to be involved in initiation and progression of certain tumors. However, The relationship between virus and pituitary adenomas (PAs) remains unknown. Here, we investigated infection status of three types of viruses (HPV16, HHV6B and HSV1) and expression l... περισσότερα »
EZH2 and ZFX oncogenes in malignant behaviour of parathyroid neoplasms
EZH2 and ZFX oncogenes in malignant behaviour of parathyroid neoplasms: AbstractSeveral studies reported somatic mutations of many genes (*MEN1*, *CTNNB1*, *CDKIs* and others) in parathyroid adenoma, although with different prevalence. Recently, activating mutations of the *EZH2* and *ZFX* oncogenes were identified in benign parathyroid adenoma by whole exome sequencing. The same mutations had been found in blood and ovary malignant tumours. On one hand, this result raised the hypothesis that these oncogenes may play a role in the onset of parathyroid tumour, but it would also sugg... περισσότερα »
Mesenchymal Stem/Stromal Cells Derived From a Reproductive Tissue Niche Under Oxidative Stress Have High Aldehyde Dehydrogenase Activity
Mesenchymal Stem/Stromal Cells Derived From a Reproductive Tissue Niche Under Oxidative Stress Have High Aldehyde Dehydrogenase Activity: AbstractThe use of mesenchymal stem/stromal cells (MSC) in regenerative medicine often requires MSC to function in environments of high oxidative stress. Human pregnancy is a condition where the mother’s tissues, and in particular her circulatory system, are exposed to increased levels of oxidative stress. MSC in the maternal *decidua basalis* (DMSC) are in a vascular niche, and thus would be exposed to oxidative stress products in the maternal c...περισσότερα »
Clonazepam in rapid eye movement sleep behavior disorder
A prospective, naturalistic follow-up study of treatment outcomes with clonazepam in rapid eye movement sleep behavior disorder: [image: sleep2994-fig-0001a.sml] • Clonazepam reduced vigorous verbal and motor behaviors, with two thirds of patients free from sleep-related injuries.• Residual rapid eye movement sleep behavior disorder (RBD) symptoms, however, were common, despite treatment.• Clonazepam changed dream affect and content while reducing motor activities.• Less optimal treatment response was associated with younger age and comorbid obstructive sleep apnea.• RBDQ-3M, a ...περισσότερα »
Low serum albumin,Extreme elevations of serum aminotransferases (EESAT),and advanced age
Low serum albumin and advanced age predict early mortality in Asian patients with extreme elevations of serum aminotransferases: Abstract Background/Aim Extreme elevations of serum aminotransferases (EESAT) reflect severe hepatic injury and are associated with poor outcome. This study aims to evaluate the prevalence, etiology and clinical outcome of EESAT in Asian patients and to identify predictors of early mortality. Methods Case records of patients admitted to a large tertiary hospital with EESAT (defined as at least one ALT and/or AST reading above 3000 U/L) over a 1-year period... περισσότερα »
How clarinettists articulate: The effect of blowing pressure and tonguing on initial and final transients
How clarinettists articulate: The effect of blowing pressure and tonguing on initial and final transients: Articulation, including initial and final note transients, is important to tasteful music performance. Clarinettists' tongue-reed contact, the time variation of the blowing pressuremouth, the mouthpiece pressure, the pressure in the instrument bore, and the radiated sound were measured for normal articulation, accents, sforzando, staccato, and for minimal attack, i.e., notes started very softly. All attacks include a phase when the amplitude of the fundamental increases expone... περισσότερα »
Unilateral Cervical Polyneuropathies following Concurrent Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer
Unilateral Cervical Polyneuropathies following Concurrent Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer: We report a constellation of cervical polyneuropathies in a patient treated with concurrent bortezomib, cetuximab, and cisplatin alongside intensity modulated radiotherapy for carcinoma of the tonsil with neck metastasis. The described deficits include brachial plexopathy, cervical sensory neuropathy, and oculosympathetic, recurrent laryngeal, and phrenic nerve palsies within the ipsilateral radiation field. Radiation neuropathy involving the brachial plexus is... περισσότερα »
Checking and rechecking tube placement
'Do it for Drew' by checking and rechecking tube placement: By Bradley Dean and David Hughes Drew Hughes, 13, died unexpectedly and tragically a few hours after sustaining a head injury while skateboarding. On June 29, 2013 a young life ended. Drew was full of vibrant life that brought laughter and light to all who knew him. Drew pushed himself to be the best that he could be, and his family encouraged him to push the limits. Every patient is somebody’s father, mother, daughter, or son. This is how Drew died and how his family, trying to bring balance back to their lives, is worki... περισσότερα »
Iliopsoas Abscess Possibly due to Klebsiella pneumoniae Infection after Chemoradiotherapy for Hypopharyngeal Cancer
Iliopsoas Abscess Possibly due to Klebsiella pneumoniae Infection after Chemoradiotherapy for Hypopharyngeal Cancer: Iliopsoas abscess was once an uncommon condition but now occurs somewhat more frequently due to the increasing number of immunocompromised patients, such as those with diabetes. We encountered a case of iliopsoas abscess following chemoradiotherapy for hypopharyngeal cancer. A 60-year-old man was admitted for a sore throat and left neck swelling. Hypopharyngeal cancer was diagnosed, but the patient refused surgery. After two rounds of chemotherapy, febrile neutropenia... περισσότερα »
HYpofractionateD RadioAblative (HYDRA) Treatment of Advanced Laryngeal Cancer
HYpofractionateD RadioAblative (HYDRA) Treatment of Advanced Laryngeal Cancer: *Condition*: Squamous Cell Carcinoma of the Larynx *Intervention*: Radiation: radiation *Sponsor*: University of Texas Southwestern Medical Center ArmsAssigned Interventions Experimental: Radiation Patients in each dose cohort will all be treated as a single group. The starting dose will be 8.5 Gy per fraction for 5 fractions (total dose = 42.5 Gy). Subsequent cohorts of patients will receive an additional 0.5 Gy per fraction. Radiation: radiation Patients in each dose cohort will all be treated as... περισσότερα »
Hearing outcome does not depend on the interval of intratympanic steroid administration in idiopathic sudden sensorineural hearing loss
Hearing outcome does not depend on the interval of intratympanic steroid administration in idiopathic sudden sensorineural hearing loss: AbstractWe studied the effect of intratympanic steroid administration with different intervals on hearing outcomes in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). The subjects were 197 consecutive patients (197 ears) with ISSNHL (hearing level ≥40 dB, interval between onset and treatment ≤30 days). They received systemic administration of prednisolone (100 mg followed by tapered doses) combined with intratympanic injection ...περισσότερα »
Clinical practice guideline: tonsillitis II. Surgical management
Clinical practice guideline: tonsillitis II. Surgical management: AbstractIn 2013, a total of 84,332 patients had undergone extracapsular tonsillectomies (TE) and 11,493 a tonsillotomy (TT) procedure in Germany. While the latter is increasingly performed, the number of the former is continually decreasing. However, a constant number of approximately 12,000 surgical procedures in terms of abscess-tonsillectomies or incision and drainage are annually performed in Germany to treat patients with a peritonsillar abscess. The purpose of this part of the clinical guideline is to provide c... περισσότερα »
Pharmacological agents used for treatment and prevention in noise-induced hearing loss
Pharmacological agents used for treatment and prevention in noise-induced hearing loss: AbstractNoise is a stress factor that causes auditory, psychological and physiological effects. The realization that sudden loud noises or chronic exposure to noise in social and working environments can cause hearing loss has led to increased interest in noise-induced hearing loss (NIHL). The best means of preventing primary damage is protection against noise. Since this protection is not always possible for various reasons, the use of pharmacological agents to prevent or treat NIHL should also... περισσότερα »
HIV-associated parotid lymphoepithelial cysts
Management algorithm for HIV-associated parotid lymphoepithelial cysts: AbstractWe report an evidence-based management algorithm for benign lymphoepithelial cysts (BLEC) of the parotid glands in HIV patients based on long-term outcomes after radiation therapy. From 1987 to 2013, 72 HIV-positive patients with BLEC of the parotid glands treated at our institutions were identified and their medical records were reviewed and analyzed. The primary endpoint of our study was to determine a dose response in HIV patients with BLEC. In group A (≤18 Gy), which received a median dose of 10 Gy ...περισσότερα »
Resistance to Thyroid Hormone Alpha
Resistance to Thyroid Hormone Alpha in an 18-Month-Old Girl: Clinical, Therapeutic, and Molecular Characteristics: Thyroid , Vol. 0, No. 0. Author information Anja L.M. van Gucht,1,2 Marcel E. Meima,1,2 Nitash Zwaveling-Soonawala,3 W. Edward Visser,1,2 Eric Fliers,4 Johanna M.B. Wennink,5 Civile Henny,6 Theo J. Visser,1,2 Robin P. Peeters,1,2,* and A.S. Paul van Trotsenburg3,* 1Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands. 2Rotterdam Thyroid Center, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The N...περισσότερα »
Capnography to assess effectiveness of pediatric ventilation
Research analysis: Capnography to assess effectiveness of pediatric ventilation: By Greg Friese, EMS1 Editor-in-Chief Capnographs from pediatric patients undergoing elective surgery were analyzed to assess the effectiveness of ventilation. The objective of the research, reported in the *American Journal of Emergency Medicine*, was to compare capnographs from three airway management techniques [1]. Data, which was a 10- to 14-second capnography, was collected on 29 patients who received ventilation with two types of masks and then ventilation with either an laryngeal mask airwa...περισσότερα »
Patients with superior canal dehiscence (SCD) suffer from events of dizziness and vertigo in response to sound, also known as Tullio phenomenon (TP)
Identifying Mechanisms Behind the Tullio Phenomenon: a Computational Study Based on First Principles: AbstractPatients with superior canal dehiscence (SCD) suffer from events of dizziness and vertigo in response to sound, also known as Tullio phenomenon (TP). The present work seeks to explain the fluid-dynamical mechanisms behind TP. In accordance with the so-called third window theory, we developed a computational model for the vestibular signal pathway between stapes and SCD. It is based on first principles and accounts for fluid–structure interactions arising between endolymph, ... περισσότερα »
Sudden sensorineural hearing loss in adults
Sudden sensorineural hearing loss in adults: Our experience with multidrug high dose steroid regimen at tertiary care hospital: *Vivek Gupta, Abhineet Jain, Praveer K Banerjee, Sonam Rathi* Indian Journal of Otology 2016 22(1):35-39 Introduction: Sudden sensorineural hearing loss is a confusing and controversial issue in our practice since no standard definition, evaluation method and treatment protocol exists. It is an otological emergency with narrow golden period of treatment. Objective: To establish the early diagnosis, treatment and study the outcome of treatment. Design a...περισσότερα »
Aural polyp: Neurofibroma of external auditory canal
Neurofibroma of external auditory canal: An unusual differential diagnosis of aural polyp: *Panduranga M Kamath, Vijendra S Shenoy, D Deviprasad, Flora D Lobo, Oj Giri* Indian Journal of Otology 2016 22(1):62-65 Neurofibromas are circumscribed but nonencapsulated neoplasms of the nervous system. They are relatively common in the nervous system, but only a few have been reported in ear. Here, we report a case of a 38-year-old female who presented with the complaints of right ear pain and right ear obstruction. Examination revealed a mass in external auditory canal, which was exc... περισσότερα »
Butterfly cartilage graft versus fat graft myringoplasty
Butterfly cartilage graft versus fat graft myringoplasty: *Sonika Kanotra, Anil Suri, Sunil Kotwal, J Paul* Indian Journal of Otology 2016 22(1):31-34 Aim: The aim of the study was to compare the graft take up rates of two minimally invasive techniques of butterfly cartilage graft (BCG) and fat graft myringoplasty (FGM). Materials and Methods: Two groups of 30 patients each with small dry central perforations of the tympanic membrane (T.M.) were randomly subjected to either of the two techniques of myringoplasty. Statistical Analysis Used: The results were compared using the ... περισσότερα »
Sudden sensorineural hearing loss posthypothyroidism
Sudden sensorineural hearing loss posthypothyroidism: A case study: *Priya Karimuddanahally Premkumar, Varsha Vijayan, Rajith Begur Nataraj, Chandni Jain* Indian Journal of Otology 2016 22(1):56-58 Sudden sensorineural hearing loss is defined as a loss of at least 30 dB in three contiguous frequencies over a period of three days or less. In the present study a client with sudden hearing loss post hypothyroidism is discussed. A 56 year old client reported of awakening from sleep due to ear fullness along with severe tinnitus and experienced reduced hearing sensitivity in the rig... περισσότερα »
Smoking and its influence on success of tympanoplasty
Smoking and its influence on success of tympanoplasty: A prospective study: *Leena Jain, Sadat Qureshi, Ashish Maurya, Shalini Jadia, Manish Jain* Indian Journal of Otology 2016 22(1):28-30 Objective: To compare the surgical outcome of tympanoplasty in smokers and nonsmokers. Design: Prospective cohort study. Setting: Tertiary Care Center in Central India. Patients: The study included 245 male patients who underwent type 1 tympanoplasty and were subsequently divided into 2 groups. Group A: Nonsmokers (115 patients). Group B: Smokers (130 patients). All the cases were operated by...περισσότερα »
Congenital aberrant internal carotid artery in the middle ear
Congenital aberrant internal carotid artery in the middle ear: 10 years follow-up: *Ahmad Marai Aldhafeeri, Munahi M Alqahtani, Ali Khalaf Alhaidey* Indian Journal of Otology 2016 22(1):48-51 An aberrant internal carotid artery (ICA) in the middle ear is a rare vascular anomaly causing objective tinnitus. The aberrant ICA (AICA) can mimic glomus tympanicum, dehiscent of jugular bulb, hemangioma, or cholesterol granuloma. The patient can exhibit nonspecific symptoms such as tinnitus, decrease hearing, and/or ear fullness. It is frequently diagnosed during surgery or biopsy, which... περισσότερα »
Adult auditory training is it part of aural rehabilitation?
Adult auditory training is it part of aural rehabilitation? Focused group discussion: *G Archana, Y Krishna, B Rajashekhar, PG Bhargavi* Indian Journal of Otology 2016 22(1):24-27 Aim: To conduct focused group discussion on audiologist and hearing aid users to find out the necessity of auditory training in adults and geriatrics. Materials and Methods: A qualitative focused group discussion was conducted on 30 audiologist and 10 hearing aid users to gather the information on auditory rehabilitation in adults and geriatrics. Eight different questions were proposed for the discussi... περισσότερα »
Pediatric rhabdomyosarcoma of the ear and temporal bone
Pediatric rhabdomyosarcoma of the ear and temporal bone: An analysis of seven cases in Sokoto, Nigeria: *Mohammed Abdullahi, SB Amutta, KR Iseh, D Aliyu, SS Yikawe, K Abdullahi* Indian Journal of Otology 2016 22(1):40-43 Background: Rhabdomyosarcoma is a common childhood soft tissue sarcoma but rare in the ear and temporal bone region, often mimicking features of chronic suppurative otitis media. Objective: The objective of this analysis is to determine the clinical pattern, stage at presentation, traditional healer intervention, and outcome. Methodology: A retrospective study o...περισσότερα »
Reasons for nonacceptance of hearing aid in older adults
Reasons for nonacceptance of hearing aid in older adults: *G Archana, Y Krishna, Ruth Shiny* Indian Journal of Otology 2016 22(1):19-23 Introduction: Hearing aids (HAs) are the electro acoustic device, developed for individuals with hearing loss. Aim: The present study was focused on analyzing the possible reasons for nonacceptance of the HAs in older adults.Methodology: A cross-sectional study was conducted in which 100 participants were enrolled in the study. Self-reported questionnaire was adapted to regional language Kannada in the first phase of the study. Adapted question...περισσότερα »
Migrated aural foreign body in parapharyngeal space
Migrated aural foreign body in parapharyngeal space: *Surya Kanta Pradhan, Sanjeev Gupta* Indian Journal of Otology 2016 22(1):66-69 Foreign bodies in ear are very frequently encountered by an otorhinolaryngologist. They should be diagnosed and removed immediately. Otherwise it may cause complications like tympanic membrane perforation, chondritis, ossicular necrosis, facial palsy, inner ear injury or it may migrate to adjacent structures. It may migrate to subcutaneous tissue or middle ear. Migration of aural foreign body to parapharyngeal space is very rare and never been rep... περισσότερα »
Prevalence, awareness, and preventive practices of noise-induced hearing loss in a plywood industry
Prevalence, awareness, and preventive practices of noise-induced hearing loss in a plywood industry: *Mukesh Edward, Sai Manohar, Gangadhara Somayaji, Hebin H Kallikkadan* Indian Journal of Otology 2016 22(1):14-18 Introduction: Noise exposure is the most common preventable cause of occupational noise-induced hearing loss (NIHL); however, once acquired, it is irreversible. The predominant damage occurs to the hair cells and their associated nerves leading to the hearing loss. Objective: To determine the prevalence and also to evaluate the awareness and practices regarding preve...περισσότερα »
Button battery cell in ear : A radiopaque double-contoured foreign body in the ear
A rare complication due to button battery cell in ear: *Sharad Hernot, Samar Pal Singh Yadav, Bhushan Kathuria, Madhuri Kaintura* Indian Journal of Otology 2016 22(1):52-55 We report a case of a 7-year-old male child who presented to ENT emergency with 24 h history of excessive pain and blackish otorrhea from right ear after accidentally inserting button battery in the ear while playing. Otoscopic examination revealed a shiny and round foreign body with excessive blackening of the surrounding skin. Chest and abdominal examination and routine investigations were normal. X-ray bil... περισσότερα »
Correlation between video-otoscopic images and tympanograms of patients with acute middle ear infection
Correlation between video-otoscopic images and tympanograms of patients with acute middle ear infection: *Ching-Shiung Ting, Kuo-Wei Huang, Yuan-Chung Tzeng* Indian Journal of Otology 2016 22(1):10-13 Objective: The tympanic membrane undergoes several changes in appearance in acute middle ear infection, which may be caused by a pressure change in the middle ear cavity. The tympanic membrane can be visualized through video-otoscopy, and the middle ear pressure can be detected through tympanometry. The objectives of this study were to assess the correlation between video-otoscopi...περισσότερα »
Nitric oxide Bhramari Pranayam and deafness
Nitric oxide Bhramari Pranayam and deafness: *MK Taneja* Indian Journal of Otology 2016 22(1):1-3 Yoga & Breathing Techniques Bhramari Pranayama (Bee Breath) Bhramari pranayama is very effective in instantly calming your mind down. It is one of the best breathing exercises to release the mind of agitation, frustration or anxiety and get rid of anger. A simple-to-do technique, can be practiced anywhere at work or home, and an instant option available to de-stress yourself. This breathing technique derives its name from the black Indian bee called Bhramari. (Bhramari = type of Ind... περισσότερα »
Proportion of hearing loss in chronic renal failure
Proportion of hearing loss in chronic renal failure: Our experience: *EK Reddy, DR Surya Prakash, Manda G. K. D. Rama Krishna* Indian Journal of Otology 2016 22(1):4-9 Introduction: This study is taken up to study the magnitude of sensorineural hearing loss (SNHL) in chronic kidney disease (CKD) patients. Two hundred patients (400 ears) who had CKD 5 and all patients underwent hemodialysis were taken into study. Methods: All patients had clinical ENT examination and audiological evaluation with pure tone audiometry and impedance audiometry. All patients had SNHL. Results: In sum...περισσότερα »
Intracochlear schwannoma
Intracochlear schwannoma: *Manoj Manikoth Puthiyaparambil, Sandeep Puthiya Koiloorveetil* Indian Journal of Otology 2016 22(1):44-47 Intracochlear schwannoma is rarely diagnosed. We report the case of a 27-year-old woman with intracochlear schwannoma who presented with 7 years history of hearing impairment. Audiological tests and imaging studies revealed a possibility of intracochlear schwannoma. Excision of the tumor was done by transcochlear approach. The histologic diagnosis was schwannoma. Her postoperative course was uneventful. We present this rare case and discuss the pr... περισσότερα »
Is cholesteatoma a precursor of verrucous carcinoma
Is cholesteatoma a precursor of verrucous carcinoma: A diagnostic dilemma: *Rohit Singh, Divya Hari Nair, Aarushi Mishra, Anshul Singh* Indian Journal of Otology 2016 22(1):59-61 Verrucous carcinoma is an unusually well-differentiated variant of squamous cell carcinoma, characterized by local invasion and cytologically benign appearance. We report a case of 52-year-old male who presented with postauricular growth and cholesteatoma in the right ear. High-resolution computed tomography temporal bone showed an enhancing soft tissue mass lesion extending into the mastoid, external a...περισσότερα »
Adverse Event Reporting in Balloon Sinus Procedures
An Analysis of Adverse Event Reporting in Balloon Sinus Procedures: Objective (1) Become familiar with reported adverse events related to balloon dilation of the paranasal sinus ostia. (2) Understand the sequelae occurring with these events. Study Design Retrospective analysis of a prospective database. Setting OpenFDA database. Subjects and Methods The OpenFDA program website of the Food and Drug Administration was queried with the Application Program Interface query system for medical device adverse events involving balloon devices for the dilation of paranasal sinus ostia fr... περισσότερα »
2015 Equilibrium Committee Amendment to the 1995 AAO-HNS Guidelines for the Definition of Menieres Disease
2015 Equilibrium Committee Amendment to the 1995 AAO-HNS Guidelines for the Definition of Menieres Disease: Ménière’s disease is a disorder of the inner ear that causes attacks of vertigo and hearing loss, tinnitus, aural fullness in the involved ear. Over the past 4 decades, the Equilibrium Committee of the AAO-HNS has issued guidelines for diagnostic criteria, with the latest version being published in 1995. These criteria were reviewed in 2015 by the Equilibrium Committee, and revisions were approved at the recent meeting of the committee at the 2015 AAO-HNSF Annual Meeting. The...περισσότερα »
Occult Nodal Disease Prevalence and Distribution in Recurrent Laryngeal Cancer Requiring Salvage Laryngectomy
Occult Nodal Disease Prevalence and Distribution in Recurrent Laryngeal Cancer Requiring Salvage Laryngectomy: Objectives The indications for neck dissection concurrent with salvage laryngectomy in the clinically N0 setting remain unclear. Our goals were to determine the prevalence of occult nodal disease, analyze nodal disease distribution patterns, and identify predictors of occult nodal disease in a salvage laryngectomy cohort. Study Design Case series with planned data collection. Setting Tertiary academic center. Subjects Patients with persistent or recurrent laryngeal squa...περισσότερα »
Implementation of a Pediatric Posttonsillectomy Pain Protocol
Implementation of a Pediatric Posttonsillectomy Pain Protocol in a Large Group Practice: Objective In response to the increased risk of respiratory failure and death after tonsillectomy related to codeine use, Kaiser Permanente Northwest restricted use of opioids in patients <7 years old via electronic health record (EHR). However, opioids could be prescribed at physician discretion by overriding the EHR. This study aims to examine protocol compliance in a large group practice using EHR order sets and complication rates as compared with historical data. Study Design Case series wi... περισσότερα »
Systematic Review on Surgical Outcomes and Hearing Preservation for Cochlear Implantation in Children and Adults
Systematic Review on Surgical Outcomes and Hearing Preservation for Cochlear Implantation in Children and Adults: Objective The mastoidectomy with facial recess approach (MFRA) is considered the reference standard for cochlear implantation. The suprameatal approach (SMA) was developed more recently and does not require mastoidectomy, which could influence postoperative outcomes. We aim to identify the optimal operative approach for cochlear implantation based on postoperative complications and hearing preservation in children and adults. Data Sources PubMed, EMBASE, Scopus, and Goo... περισσότερα »
Extracapsular Dissection with Facial Nerve Dissection for Benign Parotid Tumors
Extracapsular Dissection with Facial Nerve Dissection for Benign Parotid Tumors:
Acute Invasive Fungal Rhinosinusitis
Acute Invasive Fungal Rhinosinusitis: A 15-Year Experience with 41 Patients: Objectives To describe a 15-year single-institution experience of 41 cases of acute invasive fungal sinusitis (AIFRS), identify clinical indicators predictive of AIFRS, and discuss our approach to these high-acuity patients. Study Design Case series with chart review. Setting Tertiary referral center; The Pennsylvania State University Hershey Medical Center. Subjects and Methods A retrospective review was performed for AIFRS consultations between September 1999 and March 2014. Variables reviewed include... περισσότερα »
Utility of Surgery/Radiotherapy in Distant Metastatic Head and Neck Squamous Cell Carcinoma: A Population-Based Approach
Utility of Surgery/Radiotherapy in Distant Metastatic Head and Neck Squamous Cell Carcinoma: A Population-Based Approach: Objectives The aim of this study is to analyze the survival benefits of surgery and/or radiation therapy over no therapy in patients with metastatic (M1) squamous cell carcinoma of the head and neck region (HN-SCC). Study Design Retrospective administrative database analysis. Subjects and Methods The Surveillance, Epidemiology, and End Results (SEER) database was queried for M1 HN-SCC cases from 1988 to 2012 (6663 patients). Patient demographics, initial treatm... περισσότερα »
Tracheostomy Complications
Tracheostomy Complications in Institutionalized Children with Long-term Tracheostomy and Ventilator Dependence: Objectives (1) To identify tracheostomy complications in institutionalized children with chronic tracheostomy. (2) To determine factors that predispose to development of tracheostomy complications in institutionalized children with chronic tracheostomy. Study Design Case series with chart review over 10 years. Setting Tertiary children’s hospital. Subjects and Methods Children were included if they underwent tracheostomy before 21 years of age and resided at a pediatri...περισσότερα »
Pediatric Decannulation Protocol
A Pediatric Decannulation Protocol: Outcomes of a 10-Year Experience: Objectives (1) Describe an institutional protocol that focuses on the essential steps for decannulation of pediatric patients with long-term tracheostomies. (2) Discuss the preliminary observations of the safety of this protocol in regard to decannulation failures and successes in a selected patient population. Study Design Case series with chart review. Setting A tertiary pediatric hospital. Subjects Subjects were pediatric patients with chronic tracheostomies undergoing decannulation. Ages ranged from 1 to ... περισσότερα »
Radiologic Evidence of Cochlear Implant Bone Bed Formation Following the Subperiosteal Temporal Pocket Technique
Radiologic Evidence of Cochlear Implant Bone Bed Formation Following the Subperiosteal Temporal Pocket Technique: Objective To compare the thicknesses of bone beneath the internal receiver stimulator (IRS) with the symmetric contralateral unimplanted side in postoperative temporal high-resolution computed tomography (CT) and/or cranial CT of the patients for whom cochlear implants were secured by the subperiosteal temporal pocket technique. Study Design Case series with chart review. Setting Tertiary care hospital, cochlear implant referral center. Subjects Cochlear-implanted pe... περισσότερα »
Announcements
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EACMFS Prizes and Awards
The Council of EACMFS wishes to ensure that all members of the Association are aware of the current awards and prizes that are available. These are designed to provide educational support and also to allow the opportunity for trainees and those who have recently achieved specialist status to visit units outside their own departments. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/20Yv5pD via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Editorial Board
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Social Movements Against Racist Police Brutality and Department of Justice Intervention in Prince George’s County, Maryland
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Racist police brutality has been systemic in Prince George’s County, Maryland. The victims include African Americans, the mentally challenged, and immigrant populations, creating a complex and uneven public health impact. Three threads characterize the social movements and intervention since 1970. First, a significant demographic shift occurred as African Americans became the majority population in […]
Comparative Risk Predictions of Second Cancers after Carbon-Ion Therapy versus Proton Therapy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 16 February 2016 Source:International Journal of Radiation Oncology*Biology*Physics Author(s): John G. Eley, Thomas Friedrich, Kenneth L. Homann, Rebecca M. Howell, Michael Scholz, Marco Durante, Wayne D. Newhauser The purpose of this work was to propose a theoretical framework that enables comparative risk predictions for second cancer incidence after particle-beam therapy for […]
2016 Multidisciplinary Head and Neck Cancer Symposium will highlight leading oncology research in news briefings – DOTmed.com
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
nwitimes.com 2016 Multidisciplinary Head and Neck Cancer Symposium will highlight leading oncology research in news briefings DOTmed.com The 2016 Multidisciplinary Head and Neck Cancer Symposium, sponsored by the American Society for Radiation Oncology (ASTRO), the American Society of Clinical Oncology (ASCO) and the American Head & Neck Society (AHNS), will explore the … Cancer Patients […]
Robustness recipes for minimax robust optimization in intensity-modulated proton therapy for oropharyngeal cancer patients
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 16 February 2016 Source:International Journal of Radiation Oncology*Biology*Physics Author(s): Sebastian van der Voort, Steven van de Water, Zoltán Perkó, Ben Heijmen, Danny Lathouwers, Mischa Hoogeman PurposeTo derive a ‘robustness recipe’ giving the range (RR) and setup robustness (SR) settings – i.e. the error values – that ensure adequate CTV coverage in […]
Nodular Swelling of the Buccal Mucosa
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
A 78-year-old white woman was referred to the Oral Medicine Service of Araraquara Dental School – UNESP, Brazil, for diagnosis and management of a non-ulcerated submucosal nodule on the left side of the buccal mucosa (Figure 1, A). According to the patient, it has been present for about 1 week. Clinical examination revealed a fluctuant […]
Robust Proton Pencil Beam Scanning Treatment Planning for Rectal Cancer Radiotherapy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 16 February 2016 Source:International Journal of Radiation Oncology*Biology*Physics Author(s): Janid Patricia Blanco Kiely, Benjamin M. White PurposeRectal cancer treatment techniques that minimize dose to organs at risk (OARs) while maintaining clinical target volume (CTV) coverage could reduce treatment-related toxicities. This treatment plan design and robustness study investigates whether proton pencil beam […]
Letter to the editor in response to: Tay BD, Prabhu IS, Cousin CH, et al. Occupational exposure to noise in maxillofacial operating theatres: an initial prospective study. Br J Oral Maxillofac Surg. 2016;54:94-6
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 16 February 2016 Source:British Journal of Oral and Maxillofacial Surgery Author(s): Peter A. Brennan, Dave W. Smith from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1QHkBQW via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OfElsS via IFTTT
Lateral Tarsotomy: A Practical Alternative to Lateral Canthotomy to Increase Orbital Access
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Transconjunctival approach to the lower 1/3 of the orbit is commonly used to avoid transcutaneous incisions when surgical access is needed. A lateral canthotomy is used in conjunction with this approach if increased lateral exposure is required. A major disadvantage to the lateral canthotomy is difficulty in re-suspension of the lateral canthal tendon that can […]
Stereotactic Radiosurgery for Poor Performance Status Patients
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 16 February 2016 Source:International Journal of Radiation Oncology*Biology*Physics Author(s): Gregory J. Kubicek, Alan Turtz, Jinyu Xue, Ashish Patel, Gregory Richards, Tamara LaCouture, Louis Cappelli, Tim Diestelkamp, Piya Saraiya, Anne Bexon, Nati Lerman, Howard Warren Goldman BackgroundPatients with poor performance status (PS), usually defined as KPS 60 and less, were not eligible […]
Prevalence of human papilloma virus (HPV) and its genotypes in cervical specimens of Egyptian women by linear array HPV genotyping test
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Background The association of human papillomavirus (HPV) with cervical cancer is well established. Aim To investigate HPV genotype distribution and co-infection occurrence in cervical specimens from a group of Egyptian women. Methods A group of 152 women with and without cervical lesions were studied. All women had cervical cytology and HPV testing. They were […]
What are patients’ expectations of orthodontic treatment: a systematic review
Abstract Background What patients expect to happen during treatment or benefit from the treatment might influence the subsequent factors such as treatment outcome, patient satisfaction, patient's cooperation as well as compliance. The aim of this systematic review is to assess the role of patients' expectations from orthodontic treatment. Methods A systematic literature search of four databases Pubmed, Cochrane, Web of Science and PsychINFO was conducted following *PRISMA* guidelines. Studies reporting expectations regarding orthodontic treatment were selected and a narrative rev... περισσότερα »
Reduction of self-perceived discomforts in critically ill patients in French intensive care units: study protocol for a cluster-randomized controlled trial
Abstract Background It is now well documented that critically ill patients are exposed to stressful conditions and experience discomforts from multiple sources. Improved identification of the discomforts of patients in intensive care units (ICUs) may have implications for managing their care, including consideration of ethical issues, and may assist clinicians in choosing the most appropriate… Continue reading Reduction of self-perceived discomforts in critically ill patients in French intensive care units: study protocol for a cluster-randomized controlled trial
Residual Hearing Preservation with the Evo® Cochlear Implant Electrode Array: Preliminary Results
Int Arch Otorhinolaryngol DOI: 10.1055/s-0036-1572530 Introduction The preservation of residual hearing is currently an important challenge for cochlear implant surgeries. Indeed, if patients exhibit functional hearing after cochlear implantation, they can benefit from the combination of acoustical stimulation, usually in the low-frequencies and electrical stimulation in the high-frequencies. This combined mode of stimulation has proven to… Continue reading Residual Hearing Preservation with the Evo® Cochlear Implant Electrode Array: Preliminary Results
Erratum to: ‘Home-based palliative approach for people with severe multiple sclerosis and their carers: study protocol for a randomized controlled trial’
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“Positive to Negative” Dix-Hallpike test and Benign Paroxysmal Positional Vertigo recurrence in elderly undergoing Canalith Repositioning Maneuver and Vestibular Rehabilitation
Int Arch Otorhinolaryngol DOI: 10.1055/s-0036-1572528 Introduction Benign Paroxysmal Positional Vertigo is the most common cause of dizziness in elderly people. Recent studies have shown that the elderly present higher Benign Paroxysmal Positional Vertigo recurrence and that vertiginous symptomatology remission varies according to comorbidities and the therapeutic techniques applied. Objective To assess the short-term effectiveness of Vestibular Rehabilitation… Continue reading “Positive to Negative” Dix-Hallpike test and Benign Paroxysmal Positional Vertigo recurrence in elderly un... περισσότερα »
How to diagnose acute appendicitis: ultrasound first
Abstract Acute appendicitis (AA) is a common abdominal emergency with a lifetime prevalence of about 7 %. As the clinical diagnosis of AA remains a challenge to emergency physicians and surgeons, imaging modalities have gained major importance in the diagnostic work-up of patients with suspected AA in order to keep both the negative appendectomy rate… Continue reading How to diagnose acute appendicitis: ultrasound first
Überversorgung: Initiativen zur Identifikation ineffektiver oder nicht bedarfsgerechter Leistungen
Zusammenfassung Die Zahl der Initiativen, die sich mit einer Reduktion einer medizinischen Überversorgung zusammenfassen lassen, steigt weltweit. Immer öfter werden diese Aktivitäten von Ärzten und Klinikern selbst vorangetrieben, um nicht bedarfsgerechte medizinische Leistungen zu identifizieren und infolge zu vermeiden. Der vorliegende Artikel stellt „Choosing Wisely“ in den Kontext weniger bekannter Aktivitäten, insgesamt 13, und beschreibt… Continue reading Überversorgung: Initiativen zur Identifikation ineffektiver oder nicht bedarfsgerechter Leistungen
Adipositas: Stigmatisierung, Diskrimination, Körperimage
Zusammenfassung Bei der Adipositas handelt es sich einerseits um ein heterogenes Zustandsbild multifaktorielle Genese (genetische Prädisposition Lebensstil, soziale Situation), andererseits besteht ein weitgehend homogenes, negativ gefärbtes Stereotyp von Adipösen, da Übergewicht und Adipositas von nicht wenigen Menschen als durch körperliche Passivität und gestörtes Essverhalten selbstverschuldete Leiden angesehen werden. Adipöse Menschen sind auch deswegen weitreichenden Stigmatisierungen… Continue reading Adipositas: Stigmatisierung, Diskrimination, Körperimage
Reporting knee meniscal tears: technical aspects, typical pitfalls and how to avoid them
Abstract Magnetic resonance imaging (MRI) is the most accurate imaging technique in the diagnosis of meniscal lesions and represents a standard tool in knee evaluation. MRI plays a critical role in influencing the treatment decision and enables information that would obviate unnecessary surgery including diagnostic arthroscopy. An accurate interpretation of the knee depends on several… Continue reading Reporting knee meniscal tears: technical aspects, typical pitfalls and how to avoid them
Wise therapeutic decisions for older patients
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2016 Multidisciplinary Head and Neck Cancer Symposium will highlight leading oncology research in news briefings – DOTmed.com
nwitimes.com 2016 Multidisciplinary Head and Neck Cancer Symposium will highlight leading oncology research in news briefings DOTmed.com The 2016 Multidisciplinary Head and Neck Cancer Symposium, sponsored by the American Society for Radiation Oncology (ASTRO), the American Society of Clinical Oncology (ASCO) and the American Head & Neck Society (AHNS), will explore the … Cancer Patients… Continue reading 2016 Multidisciplinary Head and Neck Cancer Symposium will highlight leading oncology research in news briefings – DOTmed.com
Differential Response of Human Hepatocyte Chromatin to HDAC Inhibitors as a Function of Microenvironmental Glucose Level
ABSTRACT Diabetes is a complex multifactorial disorder characterized by chronic hyperglycemia due to impaired insulin secretion. Recent observations suggest that the complexity of the disease cannot be entirely accounted for genetic predisposition and a compelling argument for an epigenetic component is rapidly emerging. The use of histone deacetylase inhibitors (HDACi) in clinical setting is an emerging area of investigation. In this study, we have aimed to understand and compare the response of hepatocyte chromatin to valproic acid (VPA) and trichostatin A (TSA) treatments under ...περισσότερα »
Alteration in Phospholipidome Profile of Myoblast H9c2 Cell Line in a Model of Myocardium Starvation and Ischemia
Abstract Myocardium infarction is one of the most deathly cardiovascular diseases. It is characterized by myocardium ischemia as a result of nutrients depletion and hypoxia. The cell can respond to this injury by autophagy or apoptosis, which determines the evolution and recovery of the myocardium infarction. Lipids play an important role in cardiovascular disease. However reports stating lipidome variations in cardiovascular disease are scarce and the role that lipids play in this pathological condition is not completely understood. The aim of this work was to identify changes in ... περισσότερα »
