Oncologic outcomes of surgically treated early-stage oropharyngeal squamous cell carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
Oncologic outcomes of surgically treated early-stage oropharyngeal squamous cell carcinoma: Abstract Background The purpose of this study was to characterize oncologic outcomes in early (T1–T2, N0) and intermediate (T1–T2, N1) oropharyngeal squamous cell carcinoma (SCC) after surgery. Methods Patients with oropharyngeal SCC treated with surgery were identified from 2 academic institutions. Results Of 188 patients, 143 met the inclusion criteria. Eighty-six (60%) had T1 to T2 N0 and 57 (40%) had T1 to T2 N1 disease. Sixty-five patients (45%) underwent a robotic-assisted resection, wh... περισσότερα »
SQUIRE 2.0 Guidelines for Reporting Health Care Improvement Projects
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
SQUIRE 2.0 Guidelines for Reporting Health Care Improvement Projects: [image: ovp150007.pdf.gif] This Viewpoint discusses how the SQUIRE 2.0 guidelines provide a framework for reporting research on health care improvement.
Zenker Diverticulum
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
and Clinical Controversies in Otolaryngology: [image: oic150002.pdf.gif] Those of us trained a generation or more ago were witness to an intense effort to provide minimally invasive surgical approaches designed to reduce the adverse effects on patients, whether through miniaturization of instruments, development and implementation of endoscopes and microscopes, or advances in perioperative supportive care. Evidence that these effects have been significant across the spectrum of surgical care include examples such as endoscopic sinus surgery and laparoscopic cholecystectomy. Thi... περισσότερα »
Thyroid carcinoma with rhabdoid phenotype
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Case report with review of the literature: This paper aims to comprehensively document a rare case of thyroid carcinoma with rhabdoid phenotype and literature review of this disease. AbstractObjective This paper aims to comprehensively document a rare case of thyroid carcinoma with rhabdoid phenotype and literature review of this disease. Methods A 59-year-old man presented with a rapidly enlarging, painful left lateral cervical mass. CT scan revealed a tumor over the left the thyroid gland with multiple left cervical lymphadenopathy over left level II–IV and level VI. Fine-needl... περισσότερα »
Neck spasms: A late sequela of head and neck irradiation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Article in Press Daphna Y. Gelblumcorrespondenceemail Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, USA Marcher Thompson Department of Radiation Oncology, Mount Sinai Medical Center, 1184 Fifth Avenue, New York, NY, USA Suzanne L. Wolden, Karen D. Schupak Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, USA Sean L. Berry Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, USA Nancy Lee Department of Radiation Oncology, Me... περισσότερα »
Cutaneous neuroendocrine carcinoma of the external auditory canal
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Diagnosis and comprehensive therapy for cutaneous neuroendocrine carcinoma of the external auditory canal: a case report and literature review via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology [image: Endoscope test showing a pink, ovary-shaped neoplasm with a smooth surface. The ...] [image: Axial CT scan before surgery showing a well-circumscribed strip of solid mass in ...] [image: Vesicular nuclei, eosinophilic cytoplasm and high-density fragments could be ...] [image: Immunohistochemistry for neuron-specific enolase (NSE) (magnification 100×).] *Source:*Braz...περισσότερα »
Rate discrimination, gap detection and ranking of temporal pitch in cochlear implant users
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Rate discrimination, gap detection and ranking of temporal pitch in cochlear implant users: AbstractCochlear implant (CI) users have poor temporal pitch perception, as revealed by two key outcomes of rate discrimination tests: (i) rate discrimination thresholds (RDTs) are typically larger than the corresponding frequency difference limen for pure tones in normal hearing listeners, and (ii) above a few hundred pulses per second (i.e. the “upper limit” of pitch), CI users cannot discriminate further increases in pulse rate. Both RDTs at low rates and the upper limit of pitch vary acr... περισσότερα »
Hearing loss, short stature, seizures, intellectual impairment, muscle dysfunction, and abnormalities of the kidney and urinary system
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
A novel mutation in ACTG1 causing Baraitser-Winter syndrome with extremely variable expressivity in three generations.: Ophthalmic Genet. 2016 Apr 20;:1-5 Authors: Kemerley A, Sloan C, Pfeifer W, Smith R, Drack A Abstract Baraitser-Winter syndrome (cerebrofrontofacial syndrome, type 3) is a rare developmental disorder typified by hypertelorism, ptosis, high-arched eyebrows, ocular coloboma, and brain malformations. Other common manifestations include hearing loss, short stature, seizures, intellectual impairment, muscle dysfunction, and abnormalities of the kidney and urinary syst...περισσότερα »
Food allergy....Geraniol on ovalbumin-induced allergic asthma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Annals of Allergy, Asthma & Immunology Food allergy needs assessment, training curriculum, and knowledge assessment for child care Bruce J. Lanser, Ronina Covar, J. Andrew Bird · Friday, April 22, 2016, 3:46 More than half of preschool-aged children are enrolled in child care in the United States. Roughly 8% of children between 3 and 5 years of age have a food allergy. Child care center workers (CCCWs) are important caregivers who frequently encounter food allergies, but little is known about their education and understanding of food allergy and anaphylaxis. Tags: Allergy and Immunolog...περισσότερα »
Otorhinolaryngology
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Pediatric Otorhinolaryngology Diphtheria: it is still prevalent!!! Avani Jain, Sunil Samdani, Vinod Meena, Man Prakash Sharma · Friday, April 22, 2016, 2:31 Diphtheria is a respiratory infectious disease of childhood. It is a fatal disease and may cause complications if not recognised early and treated properly. Despite availability of effective vaccination it continues to be reported from many parts of the world particularly developing countries. Tags: ORL - - - - - Oral Oncology - Articles in Press Neck spasms: A late sequela of head and neck irradiation Daphna Y... περισσότερα »
A Mixed-Methods Study of Former Child Soldiers Transition Trajectories From Military to Civilian Life
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 13 δευτερόλεπτα
Child soldiering affects the well-being of thousands of young people globally and inflicts significant challenges on entire socio-ecological systems, confronting them with culminating stressful living conditions and immense loss. This study sought to explore how former child soldiers’ transition trajectories are shaped by the dynamic interplay between these encountered challenges and available personal and communal […]
Rate discrimination gap detection and ranking of temporal pitch in cochlear implant users
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 13 δευτερόλεπτα
Abstract Cochlear implant (CI) users have poor temporal pitch perception, as revealed by two key outcomes of rate discrimination tests: (i) rate discrimination thresholds (RDTs) are typically larger than the corresponding frequency difference limen for pure tones in normal hearing listeners, and (ii) above a few hundred pulses per second (i.e. the “upper limit” of […]
Effects of dietary cadmium and lignans on estrogen epidermal growth factor receptor and mitogen activated protein kinase signaling in vivo
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 13 δευτερόλεπτα
Publication date: Available online 22 April 2016 Source:Toxicology Letters Author(s): Imran Ali, Teija Hurmerinta, Tarja Nurmi, Marika Berglund, Joelle Rüegg, Matti Poutanen, Krister Halldin, Sari Mäkelä, Pauliina Damdimopoulou Exposure to environmental endocrine active compounds correlates with altered susceptibility to disease in human populations. Chemical risk assessment is single compound based, although exposure often takes place […]
The impact of surgeon handedness in total hip replacement
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 13 δευτερόλεπτα
Annals of The Royal College of Surgeons of England from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1VoGFHf via IFTTT
Genomic insights into abdominal aortic aneurysms
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 13 δευτερόλεπτα
Annals of The Royal College of Surgeons of England from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SnJySK via IFTTT
Breast cancer survivors perspectives on whether clinical staff should ask breast cancer patients about childhood abuse
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 13 δευτερόλεπτα
Annals of The Royal College of Surgeons of England from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1VoGImp via IFTTT
A Potent Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 13 δευτερόλεπτα
Angewandte Chemie (International ed. in English) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SnJAdi via IFTTT
Circulating Tumor Cell Biomarker Panel As an Individual-Level Surrogate for Survival in Metastatic Castration-Resistant Prostate Cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 13 δευτερόλεπτα
Journal of Clinical Oncology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1VoGFqK via IFTTT
The Effect of Temperature on Umami Taste
Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 23 δευτερόλεπτα
The effect of temperature on umami taste has not been previously studied in humans. Reported here are 3 experiments in which umami taste was measured for monopotassium glutamate (MPG) and monosodium glutamate (MSG) at solution temperatures between 10 and 37 °C. Experiment 1 showed that for subjects sensitive to MPG on the tongue tip, 1) cooling reduced umami intensity whether sampled with the tongue tip or in the whole mouth, but 2) had no effect on the rate of umami adaptation on the tongue tip. Experiment 2 showed that temperature had similar effects on the umami taste of MSG and... περισσότερα »
Childhood-onset multifocal motor neuropathy with immunoglobulin M antibodies to gangliosides GM1 and GM2: A case report and review of the literature on childhood-onset multifocal motor neuropathy (MMN) patients
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 23 δευτερόλεπτα
Publication date: Available online 21 April 2016 *Source:*Pediatric Neurology Author(s): Hidetoshi Ishigaki, Takuya Hiraide, Yoshifumi Miyagi, Taiju Hayashi, Tomoko Matsubayashi, Ayumi Shimoda, Susumu Kusunoki, Tokiko Fukuda Multifocal motor neuropathy (MMN) is a rare immune-mediated neuropathy characterized by progressive asymmetric weakness and atrophy without sensory abnormalities. Although disease onset is usually in adulthood, a few childhood-onset cases have been reported. Here, we report the case of an 8-year-old boy with MMN who presented with a slowly progressive left and d...περισσότερα »
Firefighter/Medic - Jasper County Fire-Rescue
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
please see the job announcement at http://ift.tt/1NTtYet"pageID=92 from EMS via xlomafota13 on Inoreader http://ift.tt/212ydgw via IFTTT
Synthesis of 18F-Tetrafluoroborate (18F-TFB) via Radiofluorination of Boron Trifluoride and Evaluation in a Murine C6-Glioma Tumor Model
Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 24 δευτερόλεπτα
The sodium/iodide symporter (NIS) is under investigation as a reporter for noninvasive imaging of gene expression. Although 18F-tetrafluoroborate (18F-TFB, 18F-BF4-) has shown promise as a PET imaging probe for NIS, the current synthesis method employing isotopic exchange gives suboptimal radiochemical yield and specific activity. The aim of this study was to synthesize 18F-TFB via direct radiofluorination on boron trifluoride (BF3) to enhance both labeling yield and specific activity, and evaluation of specific activity influence on tumor uptake. *Methods:* An automated synthesis ... περισσότερα »
A novel mutation in NDUFB11 unveils a new clinical phenotype associated with lactic acidosis and sideroblastic anemia
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
Abstract NDUFB11, a component of mitochondrial complex I, is a relatively small integral membrane protein, belonging to the 'supernumerary' group of subunits, but proved to be absolutely essential for the assembly of an active complex I. Mutations in in the X-linked nuclear encoded *NDUFB11* gene have recently been discovered in association with two distinct phenotypes, i.e. microphthalmia with linear skin defects and histiocytoid cardiomyopathy. We report on a male with complex I deficiency, caused by a *de novo* mutation in *NDUFB11* and displaying early onset sideroblastic anemi...περισσότερα »
The orthostatic blood pressure drop
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
QJM: An International Journal of Medicine The duration of the orthostatic blood pressure drop is predictive of death Frith, J., Bashir, A. S., Newton, J. L. · Thursday, March 31, 2016, 18:46 *Background*: Orthostatic hypotension (OH) affects 6% of community-dwelling older people. This increases to 60% when non-invasive, continuous blood pressure (BP) monitoring is used, due to identification of transient drops in BP which recover rapidly. *Aim*: To determine the clinical relevance of these transient orthostatic BP drops. *Design*: Five-year clinical observational study. *Methods*: One h... περισσότερα »
Circulating DNA in solid organ cancers
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
QJM: An International Journal of Medicine --analysis and clinical application Karampini, E., Mccaughan, F. · Thursday, March 31, 2016, 18:46 Circulating tumour DNA (ctDNA) is that fraction of circulating DNA that is derived from a patient’s cancer. For a number of years, patients with haematological malignancies have had their disease diagnosed or monitored using tests based on detecting specific cytological or molecular biomarkers in blood. It has long been appreciated that the more common epithelial malignancies also shed DNA into the blood and that this tumour-derived DNA generally...περισσότερα »
Immune and clinical response to honeybee venom in beekeepers
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Annals of Agricultural and Environmental Medicine Ann Agric Environ Med 2016; 23(1):120-124 " " Jan Matysiak, Joanna Matysiak, Anna Bręborowicz, Zdzisława Kycler, Paweł Dereziński, Zenon J Kokot · Thursday, March 31, 2016, 0:58 OBJECTIVE:The aim of the study was to assess immune response to honeybee venom in relation to the degree of exposure, time after a sting and clinical symptoms. MATERIALS AND METHOD:Fifty-four volunteers were divided into 2 groups: beekeepers and a control group. The serum levels of total IgE (tIgE), bee venom-specific IgE (venom sIgE), phospholipase A2-specific... περισσότερα »
The International Paediatric Radiation Oncology Society (PROS)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
Radiotherapy and Oncology Paediatric radiation oncology in the care of childhood cancer Friday, April 22, 2016, 5:53 Publication date: Available online 19 April 2016 *Source:*Radiotherapy and Oncology Author(s): Rolf-Dieter Kortmann, Carolyn Freeman, Karen Marcus, Line Claude, Karin Dieckmann, Edward Halperin, Natia Esiashvili, Arnold Paulino, Anita Mahajan, Klaus Seiersen, Verity Ahern, Umberto Ricardi, Christian Carrie Paediatric malignancies are a challenge for the radiation oncologist due to their rarity, the great variety of histological types, and the complexity of treatment conc...περισσότερα »
Management of chemo/radiation-induced oral mucositis in patients with head and neck cancer
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
Radiotherapy and Oncology : A review of the current literature Friday, April 22, 2016, 5:53 Publication date: Available online 21 April 2016 *Source:*Radiotherapy and Oncology Author(s): Dariush Moslemi, Akram Mohammadi Nokhandani, Mahsa Taheri Otaghsaraei, Yasaman Moghadamnia, Sohrab Kazemi, Ali Akbar Moghadamnia Oropharyngeal mucositis is an important complication in non-surgical cancer treatments. It represents the major complication in radiotherapy of tumors located in head and neck areas. Many results have been published in order to define the best clinical protocol for prophylaxis... περισσότερα »
Bone Metastases : Radiotherapy, and radiotherapy combined with bisphosphonates or RANK ligand inhibitors
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
Radiotherapy and Oncology The effect of radiotherapy, and radiotherapy combined with bisphosphonates or RANK ligand inhibitors on bone quality in bone metastases. A systematic review Friday, April 22, 2016, 5:53 Publication date: Available online 21 April 2016 *Source:*Radiotherapy and Oncology Author(s): Karlijn H.J. Groenen, Martin H. Pouw, Gerjon Hannink, Allard J.F. Hosman, Yvette M. van der Linden, Nico Verdonschot, Esther Tanck Purpose The role of radiotherapy in stabilizing metastatic bones is unclear. This systematic review assessed the effects of (1) radiotherapy, (2) radiothe...περισσότερα »
Regional nodal dissection in the axilla and groin for metastatic melanoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
ANZ Journal of Surgery Assessment of morbidity following Jane E. Theodore, Adam J. Frankel, Janine M. Thomas, Andrew P. Barbour, Gerard J. Bayley, Christopher P. Allan, Michael Wagels, B. Mark Smithers · Friday, April 22, 2016, 5:53 Background This study assessed and compared the morbidity of nodal dissection in the axilla and groin including sentinel lymph node biopsy (SLNB), completion lymph node dissection for a positive SLNB (CLND) and therapeutic lymph node dissection (TLND) with and without adjuvant radiotherapy (RT). Methods Patients who had nodal dissection in the axilla or gr... περισσότερα »
Chemical Senses
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 48 δευτερόλεπτα
Chemical Senses Behavioral Responses of CD-1 Mice to Six Predator Odor Components Sievert, T., Laska, M. · Friday, April 22, 2016, 6:15 Mammalian prey species are able to detect predator odors and to display appropriate defensive behavior. However, there is only limited knowledge about whether single compounds of predator odors are sufficient to elicit such behavior. Therefore, we assessed if predator-naïve CD-1 mice (*n* = 60) avoid sulfur-containing compounds that are characteristic components of natural predator odors and/or display other indicators of anxiety. A 2-compartment tes...περισσότερα »
Carotid Intraplaque Hemorrhage
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Neuroradiology Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA [EXTRACRANIAL VASCULAR] Eisenmenger, L. B., Aldred, B. W., Kim, S.- E., Stoddard, G. J., De Havenon, A., Treiman, G. S., Parker, D. L., Mcnally, J. S. · Friday, April 22, 2016, 6:24 BACKGROUND AND PURPOSE: Carotid intraplaque hemorrhage is associated with stroke, plaque thickness, stenosis, ulceration, and adventitial inflammation. Conflicting data exist on whether calcification is a marker of plaque instability, and no data exist on adventitial calcification. Our go...περισσότερα »
The Effect of Temperature on Umami Taste
Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
The effect of temperature on umami taste has not been previously studied in humans. Reported here are 3 experiments in which umami taste was measured for monopotassium glutamate (MPG) and monosodium glutamate (MSG) at solution temperatures between 10 and 37 °C. Experiment 1 showed that for subjects sensitive to MPG on the tongue tip, 1) cooling reduced umami intensity whether sampled with the tongue tip or in the whole mouth, but 2) had no effect on the rate of umami adaptation on the tongue tip. Experiment 2 showed that temperature had similar effects on the umami taste of MSG and... περισσότερα »
Metallic Embolism
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Neuroradiology Suspected Metallic Embolism following Endovascular Treatment of Intracranial Aneurysms [INTERVENTIONAL] Yasuda, R., Maeda, M., Umino, M., Nakatsuka, Y., Umeda, Y., Toma, N., Sakaida, H., Suzuki, H. · Friday, April 22, 2016, 6:24 SUMMARY: We describe a case series of suspected metallic embolism after coil embolization for intracranial aneurysms. Between January 2012 and December 2014, 110 intracranial aneurysms had been treated by coil embolization in our institution. In 6 cases, the postprocedural MR imaging revealed abnormal spotty lesions not detected on the preproced... περισσότερα »
Ischemic Complications following Pipeline Embolization Device Treatment of Intracranial Aneurysms
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Neuroradiology Risk Factors for : Results from the IntrePED Study [INTERVENTIONAL] Brinjikji, W., Lanzino, G., Cloft, H. J., Siddiqui, A. H., Boccardi, E., Cekirge, S., Fiorella, D., Hanel, R., Jabbour, P., Levy, E., Lopes, D., Lylyk, P., Szikora, I., Kallmes, D. F. · Friday, April 22, 2016, 6:24 BACKGROUND AND PURPOSE: Risk factors for acute ischemic stroke following flow-diverter treatment of intracranial aneurysms are poorly understood. Using the International Retrospective Study of Pipeline Embolization Device (IntrePED) registry, we studied demographic, aneurysm, and procedural ch... περισσότερα »
The Woven EndoBridge (WEB) device for intrasaccular treatment of wide-neck aneurysms
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Neuroradiology WEB Treatment of Ruptured Intracranial Aneurysms [INTERVENTIONAL] Van Rooij, W. J., Peluso, J. P., Bechan, R. S., Sluzewski, M. · Friday, April 22, 2016, 6:24 BACKGROUND AND PURPOSE: The Woven EndoBridge (WEB) device was recently introduced for intrasaccular treatment of wide-neck aneurysms without the need for adjunctive support. We present our first experience in using the WEB for small ruptured aneurysms. MATERIALS AND METHODS: During 11 months, 32 of 71 (45%) endovascularly treated acutely ruptured aneurysms were treated with the WEB. The patients were 12 men and 20 ... περισσότερα »
Benign neoplasm of the minor salivary gland : Monomorphic adenoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Journal of Dental and Allied Sciences Case report and review of literature Harish S Kulkarni · Friday, April 22, 2016, 6:53 *Harish S Kulkarni, Gayithri H Kulkarni, Shahanavaj I Khaji, Ehtesham Iqbal, Jyoti M Biradar* Journal of Dental and Allied Sciences 2014 3(2):108-110 Monomorphic adenoma is a rare benign salivary gland epithelial tumor representing <3% of all tumors in general population, and more than 80% of them arise in the major salivary glands, mostly the parotid gland and rarely in upper lip, buccal mucosa - as observed in the present case. Monomorphic adenomas are defined a... περισσότερα »
Ranula in an adolescent patient
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα
Journal of Dental and Allied Sciences Ranula in an adolescent patient Rashmi Singh Chauhan · Friday, April 22, 2016, 6:53 *Rashmi Singh Chauhan, Vivek Singh Chauhan, Dayanand Shirol, Gauri Lele* Journal of Dental and Allied Sciences 2014 3(2):105-107 Ranula is a mucus extravasation cyst arising from the sublingual gland. The name "ranula" has been derived from the Latin word "rana" which means "frog." The swelling resembles a frog's translucent underbelly or air sacs. Ranula usually appears as a painless, fluctuant swelling. It usually occurs unilaterally and in young adults. This paper...περισσότερα »
Treatment of skeletal class II malocclusion with the combination of twin-block and combination-pull headgear
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα
Journal of Dental and Allied Sciences Sameer S Patil · Friday, April 22, 2016, 6:53 *Sameer S Patil, Sandesh S Baralay, Sheetal S Potnis* Journal of Dental and Allied Sciences 2014 3(2):102-104 The patient was a girl with a Class II division 1 malocclusion, a large overjet, an excessively deep overbite, and a slightly increased mandibular plane angle. Treatment started with the Twin-block appliance combined with combination-pull headgear to promote growth of the mandible, restrain the maxilla in the anteroposterior plane, and improve her profile. This was later, followed by fixed appli... περισσότερα »
Bilateral unicystic ameloblastoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα
Journal of Dental and Allied Sciences : 2014 - 3(2) An unusual case of bilateral unicystic ameloblastoma in third molar region Vikram Deshmukh · Friday, April 22, 2016, 6:53 *Vikram Deshmukh, Raunak Sunil Patwa, Prachi Bhanudas Chhindam, Nikhil Joshi* Journal of Dental and Allied Sciences 2014 3(2):99-101 Unicystic ameloblastoma (UA) is less encountered variant which is believed to be less aggressive. A rare case of bilateral unicystic mural ameloblastoma in a 24 year old pregnant female is presented which was treated by en-block resection with preservation of the lower border of the m... περισσότερα »
Saliva and gingival crevicular fluid
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
Journal of Dental and Allied Sciences A new dawn in modern perio-diagnostics: Harpreet Singh Grover · Friday, April 22, 2016, 6:53 *Harpreet Singh Grover, Rohit Saini, Pearl Bhardwaj, Amit Bhardwaj* Journal of Dental and Allied Sciences 2014 3(2):89-92 Periodontal disease is a chronic microbial infection. There is a need for the evolvement of contemporary diagnostic tests to improve the clinical management. Molecular arrays for the detection of biomarkers on the different stages of the disease help in understanding various mediators of the disease process. This evolutionary process has...περισσότερα »
Conventional and digital cephalometric analysis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
Journal of Dental and Allied Sciences Comparison of conventional and digital cephalometric analysis: A pilot study Hemlata Bhagwan Tanwani · Friday, April 22, 2016, 6:53 *Hemlata Bhagwan Tanwani, Sheetal Sameer Potnis, Sandesh Satish Baralay, Sameer Sidagouda Patil* Journal of Dental and Allied Sciences 2014 3(2):80-84 Aim: The aim of the study was to analyze and compare the manual cephalometric tracings with computerized cephalometric tracings using Burstone hard tissue analysis and McNamara analysis. Materials and Methods: Conventional lateral cephalograms of 20 subjects were obtained... περισσότερα »
Pulse Oximetry
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
Respiratory Care current issue The Objective Use of Pulse Oximetry to Predict Respiratory Support Transition in Preterm Infants: An Observational Pilot Study Mascoll-robertson, K. K., Viscardi, R. M., Woo, H. C. BACKGROUND:Preterm infants often require some form of respiratory support with supplemental oxygen and are monitored by continuous pulse oximetry (SpO2). The study objective was to determine whether the histogram distribution of SpO2 over a 24-h period will predict readiness for weaning respiratory support in preterm infants. We hypothesize that infants with ≥15% of time spent...περισσότερα »
Right Versus Left Prong Nasal Cannula Flow Delivery and the Effects of Nasal Cycling on Inspired FIO2
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
Respiratory Care current issue in an Adult Anatomic Model Marshall, S. G., Henry, N. R., Russian, C. J. · BACKGROUND:Nasal cycling may present negative consequences for oxygen-dependent patients using a nasal cannula. This study investigates the effects of nasal cycling on the delivered FIO2 via nasal cannula in an anatomic model following a baseline study comparing right and left prong nasal cannula oxygen flow delivery.METHODS:Flow from right and left nasal cannula prongs were measured simultaneously using thermal mass flow meters while delivering 0.5–6-L/min oxygen for 5 nasal can... περισσότερα »
Rate discrimination gap detection and ranking of temporal pitch in cochlear implant users
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 57 δευτερόλεπτα
Abstract Cochlear implant (CI) users have poor temporal pitch perception, as revealed by two key outcomes of rate discrimination tests: (i) rate discrimination thresholds (RDTs) are typically larger than the corresponding frequency difference limen for pure tones in normal hearing listeners, and (ii) above a few hundred pulses per second (i.e. the “upper limit” of… Continue reading Rate discrimination gap detection and ranking of temporal pitch in cochlear implant users
Widespread Focal Cortical Alterations in Autism Spectrum Disorder with Intellectual Disability Detected by Threshold-Free Cluster Enhancement PEDIATRICS
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 57 δευτερόλεπτα
BACKGROUND AND PURPOSE: In the past decades, a large body of work aimed at investigating brain structural anomalies accrued in autism spectrum disorder. Autism spectrum disorder is associated with intellectual disability in up to 50% of cases. However, only a few neuroimaging studies were conducted in autism spectrum disorder with intellectual disability, and none of… Continue reading Widespread Focal Cortical Alterations in Autism Spectrum Disorder with Intellectual Disability Detected by Threshold-Free Cluster Enhancement PEDIATRICS
Gray Matter Growth Is Accompanied by Increasing Blood Flow and Decreasing Apparent Diffusion Coefficient during Childhood PEDIATRICS
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 57 δευτερόλεπτα
BACKGROUND AND PURPOSE: Normal values of gray matter volume, cerebral blood flow, and water diffusion have not been established for healthy children. We sought to determine reference values for age-dependent changes of these parameters in healthy children. MATERIALS AND METHODS: We retrospectively reviewed MR imaging data from 100 healthy children. Using an atlas-based approach, age-related… Continue reading Gray Matter Growth Is Accompanied by Increasing Blood Flow and Decreasing Apparent Diffusion Coefficient during Childhood PEDIATRICS
Geometric Parameter Analysis of Ruptured and Unruptured Aneurysms in Patients with Symmetric Bilateral Intracranial Aneurysms: A Multicenter CT Angiography Study INTERVENTIONAL
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 57 δευτερόλεπτα
BACKGROUND AND PURPOSE: Previous studies of geometric and morphologic parameters of intracranial aneurysms have been conducted to determine rupture risk, which remains incompletely defined due to patient-specific risk factors, such as sex, hypertension, and age. To this end, we compared characteristics of ruptured and unruptured aneurysms in the same patients with symmetric bilateral intracranial aneurysms.… Continue reading Geometric Parameter Analysis of Ruptured and Unruptured Aneurysms in Patients with Symmetric Bilateral Intracranial Aneurysms: A Multicenter CT Angiography Stud... περισσότερα »
Suspected Metallic Embolism following Endovascular Treatment of Intracranial Aneurysms INTERVENTIONAL
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 57 δευτερόλεπτα
SUMMARY: We describe a case series of suspected metallic embolism after coil embolization for intracranial aneurysms. Between January 2012 and December 2014, 110 intracranial aneurysms had been treated by coil embolization in our institution. In 6 cases, the postprocedural MR imaging revealed abnormal spotty lesions not detected on the preprocedural MR imaging. The lesions were… Continue reading Suspected Metallic Embolism following Endovascular Treatment of Intracranial Aneurysms INTERVENTIONAL
Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA EXTRACRANIAL VASCULAR
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 57 δευτερόλεπτα
BACKGROUND AND PURPOSE: Carotid intraplaque hemorrhage is associated with stroke, plaque thickness, stenosis, ulceration, and adventitial inflammation. Conflicting data exist on whether calcification is a marker of plaque instability, and no data exist on adventitial calcification. Our goal was to determine whether adventitial calcification and soft plaque (a rim sign) help predict carotid intraplaque hemorrhage.… Continue reading Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA EXTRACRANIAL VASCULAR
Contrast-Enhanced and Time-of-Flight MRA at 3T Compared with DSA for the Follow-Up of Intracranial Aneurysms Treated with the WEB Device INTERVENTIONAL
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 57 δευτερόλεπτα
BACKGROUND AND PURPOSE: Imaging follow-up at 3T of intracranial aneurysms treated with the WEB Device has not been evaluated yet. Our aim was to assess the diagnostic accuracy of 3D–time-of-flight MRA and contrast-enhanced MRA at 3T against DSA, as the criterion standard, for the follow-up of aneurysms treated with the Woven EndoBridge (WEB) system. MATERIALS… Continue reading Contrast-Enhanced and Time-of-Flight MRA at 3T Compared with DSA for the Follow-Up of Intracranial Aneurysms Treated with the WEB Device INTERVENTIONAL
Endovascular Treatment versus Best Medical Treatment in Patients with Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials ADULT BRAIN
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 57 δευτερόλεπτα
BACKGROUND AND PURPOSE: Endovascular treatment has emerged as a minimally invasive technique for patients with acute ischemic stroke to achieve recanalization. Our aim was to determine the effects of endovascular treatment on clinical and safety outcomes compared with best medical treatment. MATERIALS AND METHODS: Fifteen randomized trials that compared endovascular treatment with best medical treatment… Continue reading Endovascular Treatment versus Best Medical Treatment in Patients with Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials ADULT BRAIN
Rituximab Desensitization in Pediatric Patients,Management of Food Allergy to Fish with Oral Immunotherapy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Pediatric Allergy, Immunology, and Pulmonology Rituximab Desensitization in Pediatric Patients: Results of a Case Series Meredith A. Dilley · Tuesday, April 19, 2016, 18:17 Pediatric Allergy, Immunology, and Pulmonology , Vol. 0, No. 0. Author information Meredith A. Dilley, MD,1,2 Joyce P. Lee, Pharm D, BCPS,1 Craig D. Platt, MD, PhD,1,2 and Ana Dioun Broyles, MD1,2 1Boston Children's Hospital, Boston, Massachusetts. 2Harvard Medical School, Boston, Massachusetts. Address correspondence to: *Meredith A. Dilley, MD* *Boston Children's Hospital* *300 Longwood Avenue* *Fegan 6* *Boston, MA ... περισσότερα »
Ultrasound in Medicine
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Journal of Ultrasound in Medicine current issue Fetal Cardiac Screening: What Are We (and Our Guidelines) Doing Wrong? Sklansky, M., Devore, G. R. · Tuesday, March 29, 2016, 6:22 Tags: - - - - - - Journal of Ultrasound in Medicine current issue Sonography of Common Peripheral Nerve Disorders With Clinical Correlation Jacobson, J. A., Wilson, T. J., Yang, L. J.- S. · Tuesday, March 29, 2016, 6:22 Sonography is now considered an effective method to evaluate peripheral nerves. Low cost, high resolution, the ability to image an entire limb in a short time, and dynamic a... περισσότερα »
Oral Rehabilitation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Journal of Oral Rehabilitation Maximum bite force at age 70 years predicts all-cause mortality during the following 13 years in Japanese men M. Iwasaki, A. Yoshihara, N. Sato, M. Sato, G. W. Taylor, T. Ansai, T. Ono, H. Miyazaki ·Saturday, April 16, 2016, 5:59 Summary There is limited information on the impact of oral function on mortality among older adults. The aim of this prospective cohort study was to examine whether an objective measure of oral function, maximum bite force (MBF), is associated with mortality in older adults during a 13-year follow-up period. Five hundred and fif... περισσότερα »
Computer Assisted Tomography
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Journal of Computer Assisted Tomography - Published Ahead-of-Print Intracardiac Embolized Prostate Brachytherapy Seeds: Imaging Features in Patients Undergoing Electrocardiogram-Gated Cardiac Computed Tomography. Halpenny, Darragh F.; Latson, Larry Jr; Mason, Derek; Donnino, Robert; Alpert, Jeffrey; Jacobs, Jill E. · Thursday, April 21, 2016, 10:20 Objective: This study aims to provide the first description of the computed tomographic (CT) appearances of intracardiac embolized brachytherapy seeds in patients undergoing electrocardiogram (ECG)-gated cardiac CT. Methods: The institutiona... περισσότερα »
Clinical Oncology
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Japanese Journal of Clinical Oncology - current issue IN THIS ISSUE Tuesday, March 29, 2016, 19:40 Tags: - - - - - - Japanese Journal of Clinical Oncology - current issue Skin problems and EGFR-tyrosine kinase inhibitor Kozuki, T. · Tuesday, March 29, 2016, 19:40 Epidermal growth factor receptor inhibition is a good target for the treatment of lung, colon, pancreatic and head and neck cancers. Epidermal growth factor receptor-tyrosine kinase inhibitor was first approved for the treatment of advanced lung cancer in 2002. Epidermal growth factor receptor-tyrosine kin... περισσότερα »
Innate Immunity
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Innate Immunity current issue Yeast-containing feed additive alters gene expression profiles associated with innate immunity in whole blood of a rodent model Branson, J. A., Mclean, D. J., Forsberg, N. E., Bobe, G. · Friday, April 15, 2016, 16:54 Feeding a yeast-containing additive (YCA; OmniGen-AF) improves immune responses in ruminant livestock and reduces subsequent production losses. The objective was to identify molecular pathways by which dietary YCA may modify immune responses using a rodent model. Thirty-seven healthy, unchallenged CD rats received a diet containing 0 (control...περισσότερα »
Hellenic Anticancer Institute
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Hellenic Anticancer Institute From Inflammation to Cancer in Inflammatory Bowel Disease: Molecular Perspectives Romano, M., De Francesco, F., Zarantonello, L., Ruffolo, C., Ferraro, G. A., Zanus, G., Giordano, A., Bassi, N., Cillo, U. · Monday, April 11, 2016, 17:43 Inflammatory bowel diseases (IBD) are associated with an increased risk of colitis-associated colorectal carcinoma (CAC). CAC is one of the most important causes of morbidity and mortality in patients with Crohn's disease and ulcerative colitis. The aim of the present review was to discuss the most important signaling pat... περισσότερα »
Hearing
στοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Hearing Delivery of Audiology Services: Differentiation in an Evolving Health Care Marketplace Windmill, Ian M. · Saturday, April 09, 2016, 15:01 Semin Hear 2016; 37: 101-102 DOI: 10.1055/s-0036-1579707 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. Article in Thieme eJournals: Table of contents | Full text Tags: - - - - - - Hearing Application of the Consumer Decision-Making Model to Hearing Aid Adoption in First-Time Users Amlani, Amyn M. · Saturday, April 09, 2016, 15:01 Semin Hear 2016; 37: 103-119 DOI: 10.1055/s-0036-1579706 Since 1980... περισσότερα »
First in human assessment of the novel PDE2A PET radiotracer 18F-PF-05270430
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Objectives: This was a first-in-human study of the novel phosphodiesterase-2A (PDE2A) PET ligand, 18F-PF-05270430. Primary goals were to determine the appropriate tracer kinetic model to quantify brain uptake, and to examine the within-subject test-retest variability. *Methods:* In advance of human studies, radiation dosimetry was determined in nonhuman primates. Six healthy male subjects participated in a test/retest protocol with dynamic scans and metabolite-corrected input functions. Nine brain regions of interest were studied, including striatum, white matter, neocortical regi... περισσότερα »
PET Measurement of Renal GFR: Is there a role in Nuclear Medicine
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
from #Medicine via ola Kala on Inoreader http://ift.tt/23NbKcy Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Using in-cell SHAPE-Seq and simulations to probe structure-function design principles of RNA transcriptional regulators [ARTICLE]
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Antisense RNA-mediated transcriptional regulators are powerful tools for controlling gene expression and creating synthetic gene networks. RNA transcriptional repressors derived from natural mechanisms called attenuators are particularly versatile, though their mechanistic complexity has made them difficult to engineer. Here we identify a new structure–function design principle for attenuators that enables the forward engineering of new RNA transcriptional repressors. Using in-cell SHAPE-Seq to characterize the structures of attenuator variants within *Escherichia coli*, we show t... περισσότερα »
Arterial Stiffness
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Experimental and Clinical Endocrinology & Diabetes Arterial Stiffness, BMI, Dipping Status and ACE D/I Polymorphism in Type 1 Diabetic Children Pietrzak, I. · Thursday, April 07, 2016, 2:35 Exp Clin Endocrinol Diabetes DOI: 10.1055/s-0042-101243 The aim: of the study was to investigate clinical and genetic determinants of arterial stiffness in children and adolescents with type 1 diabetes mellitus. Material and Methods: 122 patients (mean age: 16.0±2.35 years), with an average diabetes duration of 5.0 years and without evidence of arterial hypertension were recruited. Ambulatory arteri...περισσότερα »
Sclerosing hemangioma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
CytoJournal : A diagnostic dilemma in fine needle aspiration cytology Jennifer Zeng · Wednesday, April 20, 2016, 22:27 *Jennifer Zeng, Fang Zhou, Xiao-Jun Wei, Sandor Kovacs, Aylin Simsir, Yan Shi* CytoJournal 2016 13(1):9-9 Sclerosing hemangioma of the lung is a benign neoplasm with a widely debated histogenesis. It has a polymorphic histomorphology characterized by a biphasic cell population of "surface cells" and "round cells" arranged in four general patterns: Papillary, solid, angiomatous, and sclerotic. This variability in histomorphology makes it difficult to diagnose sclerosing... περισσότερα »
Allergy and Clinical Immunology
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Current Opinion in Allergy and Clinical Immunology - Published Ahead-of-Print Are genetic tests informative in predicting food allergy?. Li, Jin; Maggadottir, S. Melkorka; Hakonarson, Hakon · Wednesday, April 13, 2016, 10:41 Purpose of review: Food allergy is common among children and adults worldwide. Recent studies have improved our understanding of the genetic mechanism of food allergy and further studies may result in clinical application through genetic testing. Recent findings: Genetic factors are important in the development of food allergy. An increasing number of genes have ...περισσότερα »
Management of chemo/radiation-induced oral mucositis in patients with head and neck cancer: A review of the current literature
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 21 April 2016 *Source:*Radiotherapy and Oncology Author(s): Dariush Moslemi, Akram Mohammadi Nokhandani, Mahsa Taheri Otaghsaraei, Yasaman Moghadamnia, Sohrab Kazemi, Ali Akbar Moghadamnia Oropharyngeal mucositis is an important complication in non-surgical cancer treatments. It represents the major complication in radiotherapy of tumors located in head and neck areas. Many results have been published in order to define the best clinical protocol for prophylaxis or treatment of mucositis, but a consensus has not been attained yet. In this review, so... περισσότερα »
Image guided adaptive brachytherapy with combined intracavitary and interstitial technique improves the therapeutic ratio in locally advanced cervical cancer: Analysis from the retroEMBRACE study
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 21 April 2016 *Source:*Radiotherapy and Oncology Author(s): Lars Fokdal, Alina Sturdza, Renaud Mazeron, Christine Haie-Meder, Li Tee Tan, Charles Gillham, Barbara Šegedin, Ina Jürgenliemk-Schultz, Christian Kirisits, Peter Hoskin, Richard Pötter, Jacob C. Lindegaard, Kari Tanderup Background and purposeImage guided adaptive brachytherapy (IGABT) using intracavitary applicators (IC) has led to a significant improvement of local control in locally advanced cervical cancer (LACC). Further improvement has been obtained with combined intracavitary/inter... περισσότερα »
Plasma ceramide a real-time predictive marker of pulmonary and hepatic metastases response to stereotactic body radiation therapy combined with irinotecan
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 21 April 2016 *Source:*Radiotherapy and Oncology Author(s): Nolwenn Dubois, Emmanuel Rio, Natacha Ripoche, Véronique Ferchaud-Roucher, Marie-Hélène Gaugler, Loic Campion, Michel Krempf, Christian Carrie, Marc Mahé, Xavier Mirabel, François Paris Background and purposesEarly biomarkers of tumour response are needed to discriminate between responders and non-responders to radiotherapy. We evaluated the ability of ceramide, a bioactive sphingolipid, to predict tumour sensitivity in patients treated by hypofractionated stereotactic body radiation thera...περισσότερα »
Timely tumor response analysis after preoperative chemoradiotherapy and curative surgery in locally advanced rectal cancer: A multi-institutional study for optimal surgical timing in rectal cancer
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 19 April 2016 *Source:*Radiotherapy and Oncology Author(s): Yoo-Kang Kwak, Kyubo Kim, Jong Hoon Lee, Sung Hwan Kim, Hyeon Min Cho, Dae Yong Kim, Tae Hyun Kim, Sun Young Kim, Ji Yeon Baek, Jae Hwan Oh, Taek Keun Nam, Mee Sun Yoon, Jae Uk Jeong, Eui Kyu Chie, Hong Seok Jang, Jae Sung Kim Background and purposeThe definite surgical timing in rectal cancer after preoperative chemoradiotherapy (CRT) has not yet been fully examined. We assess the tumor response and identify the optimal operation timing after preoperative CRT in rectal cancer.Methods and ... περισσότερα »
In reply to Borras et al. The strengthening of Radiation Oncologist role inside multidisciplinary arena within 2025
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 19 April 2016 *Source:*Radiotherapy and Oncology Author(s): Filippo Alongi, Niccolò Giaj-Levra, Sergio Fersino, Michela Buglione di Monale e Bastia, Stefano Magrini from Rathiotherapy via ola Kala on Inoreader http://ift.tt/246cExx via IFTTT
The effect of radiotherapy and radiotherapy combined with bisphosphonates or RANK ligand inhibitors on bone quality in bone metastases. A systematic review
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 21 April 2016 *Source:*Radiotherapy and Oncology Author(s): Karlijn H.J. Groenen, Martin H. Pouw, Gerjon Hannink, Allard J.F. Hosman, Yvette M. van der Linden, Nico Verdonschot, Esther Tanck PurposeThe role of radiotherapy in stabilizing metastatic bones is unclear. This systematic review assessed the effects of (1) radiotherapy, (2) radiotherapy combined with bisphosphonates, and (3) radiotherapy combined with RANK ligand (RANKL) inhibitors on bone quality and bone strength in bone metastases originating from solid tumors.MethodsPubmed, EMBASE and ...περισσότερα »
Phase I trial of vorinostat added to chemoradiation with capecitabine in pancreatic cancer
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 19 April 2016 *Source:*Radiotherapy and Oncology Author(s): Emily Chan, Lori R. Arlinghaus, Dana B. Cardin, Laura Goff, Jordan D. Berlin, Alexander Parikh, Richard G. Abramson, Thomas E. Yankeelov, Scott Hiebert, Nipun Merchant, Srividya Bhaskara, Anuradha Bapsi Chakravarthy Background and purposeThis single institution phase I trial determined the maximum tolerated dose (MTD) of concurrent vorinostat and capecitabine with radiation in non-metastatic pancreatic cancer.Material and methodsTwenty-one patients received escalating doses of vorinostat ... περισσότερα »
Correlation between DNA damage responses of skin to a test dose of radiation and late adverse effects of earlier breast radiotherapy
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 19 April 2016 *Source:*Radiotherapy and Oncology Author(s): Navita Somaiah, Melvin L.K. Chua, Sara Bourne, Frances Daley, Roger A' Hern, Otilia Nuta, Lone Gothard, Sue Boyle, Carsten Herskind, Ann Pearson, Jim Warrington, Sarah Helyer, Roger Owen, Kai Rothkamm, John Yarnold AimTo correlate residual double strand breaks (DSB) 24h after 4Gy test doses to skin in vivo and to lymphocytes in vitro with adverse effects of earlier breast radiotherapy (RT).Patients and methodsPatients given whole breast RT ⩾5years earlier were identified on the basis of mo... περισσότερα »
Paediatric radiation oncology in the care of childhood cancer: A position paper by the International Paediatric Radiation Oncology Society (PROS)
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 19 April 2016 *Source:*Radiotherapy and Oncology Author(s): Rolf-Dieter Kortmann, Carolyn Freeman, Karen Marcus, Line Claude, Karin Dieckmann, Edward Halperin, Natia Esiashvili, Arnold Paulino, Anita Mahajan, Klaus Seiersen, Verity Ahern, Umberto Ricardi, Christian Carrie Paediatric malignancies are a challenge for the radiation oncologist due to their rarity, the great variety of histological types, and the complexity of treatment concepts that evolve over time. The Paediatric Radiation Oncology Society (PROS) is the only internationally operating... περισσότερα »
A national approach for automated collection of standardized and population-based radiation therapy data in Sweden
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 18 April 2016 *Source:*Radiotherapy and Oncology Author(s): Tufve Nyholm, Caroline Olsson, Måns Agrup, Peter Björk, Thomas Björk-Eriksson, Giovanna Gagliardi, Hanne Grinaker, Adalsteinn Gunnlaugsson, Anders Gustafsson, Magnus Gustafsson, Bengt Johansson, Stefan Johnsson, Magnus Karlsson, Ingrid Kristensen, Per Nilsson, Leif Nyström, Eva Onjukka, Johan Reizenstein, Johan Skönevik, Karin Söderström, Alexander Valdman, Björn Zackrisson, Anders Montelius PurposeTo develop an infrastructure for structured and automated collection of interoperable radiat... περισσότερα »
Prophylactic irradiation of para-aortic lymph nodes for patients with locally advanced cervical cancers with and without high CA9 expression (KROG 07-01): A randomized open-label multicenter phase 2 trial
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 18 April 2016 *Source:*Radiotherapy and Oncology Author(s): Jin Hee Kim, Joo-Young Kim, Mee Sun Yoon, Young Seok Kim, Jong Hoon Lee, Hak Jae Kim, Hunjung Kim, Yeon-Joo Kim, Chong Woo Yoo, Byung-Ho Nam, Tae Hyun Kim, Suk-Ki Kim, Sun Ho Kim, Seokbom Kang, Sang Soo Seo, Myong Cheol Lim, Sang-Yoon Park Background and purposeThe efficacy of prophylactic extended-field irradiation (EFI) plus concomitant cisplatin in patients with locally advanced uterine cervical cancer (LAUCC) is unknown, nor is it known whether tumor carbonic anhydrase IX (CA9) express... περισσότερα »
Patient-specific online dose verification based on transmission detector measurements
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 16 April 2016 *Source:*Radiotherapy and Oncology Author(s): Johannes Thoelking, Jens Fleckenstein, Yuvaraj Sekar, Ramesh Boggula, Frank Lohr, Frederik Wenz, Hansjoerg Wertz Background and purposeSince IMRT-techniques lead to an increasingly complicated environment, a patient specific IMRT-plan verification is recommended. Furthermore, verifications during patient irradiation and 3D dose reconstruction have the potential to improve treatment delivery, accuracy and safety. This study provides a detailed investigation of the new transmission detector ...περισσότερα »
Radiomic phenotype features predict pathological response in non-small cell lung cancer
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 13 April 2016 *Source:*Radiotherapy and Oncology Author(s): Thibaud P. Coroller, Vishesh Agrawal, Vivek Narayan, Ying Hou, Patrick Grossmann, Stephanie W. Lee, Raymond H. Mak, Hugo J.W.L. Aerts Background and purposeRadiomics can quantify tumor phenotype characteristics non-invasively by applying advanced imaging feature algorithms. In this study we assessed if pre-treatment radiomics data are able to predict pathological response after neoadjuvant chemoradiation in patients with locally advanced non-small cell lung cancer (NSCLC).Materials and Met... περισσότερα »
Normal tissue considerations and dosevolume constraints in the moderately hypofractionated treatment of non-small cell lung cancer
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 12 April 2016 *Source:*Radiotherapy and Oncology Author(s): Cathy Fleming, Daniel N. Cagney, Serena O'Keeffe, Sinead M. Brennan, John G. Armstrong, Brendan McClean Hypofractionated radiation therapy (RT) regimes in non-small cell lung cancer (NSCLC) have become increasingly popular with a number of international trials currently underway. The majority of the dose–volume-constraints (DVCs) published in the literature refer to conventional 2Gy per fraction deliveries. Here relevant organs-at-risk (OARs) are identified and available dose–volume constr... περισσότερα »
The advantage of deep-inspiration breath-hold and cone-beam CT based soft-tissue registration for locally advanced lung cancer radiotherapy
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 9 April 2016 *Source:*Radiotherapy and Oncology Author(s): Wiviann Ottosson, Fatma Rahma, David Sjöström, Claus F. Behrens, Patrik Sibolt Background and purposeThree cone-beam computed tomography (CBCT) registration strategies combined with deep-inspiration breath-hold (DIBH) and free-breathing (FB) were explored, in terms of obtaining the smallest planning target volume (PTV).Material and methodsCBCT images were acquired pre- and post-treatment in FB and DIBH, for 17 locally advanced lung cancer patients. Bony registration on the spine, and soft-t...περισσότερα »
Comparison of patient-reported outcomes with single versus multiple fraction palliative radiotherapy for bone metastasis in a population-based cohort
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 9 April 2016 *Source:*Radiotherapy and Oncology Author(s): Jessica L. Conway, Emily Yurkowski, Justin Glazier, Quinn Gentles, Allison Walter, Gale Bowering, Susan Curtis, Devin Schellenberg, Ross Halperin, Vincent Lapointe, Wayne Beckham, Ivo A. Olivotto, Robert Anton Olson BackgroundDespite randomized control trials showing equivalent efficacy between single-fraction (SF) and multiple-fraction (MF) radiation therapy (RT) for bone metastases (BoM), considerable variation in fractionation exists. We compared patient-reported outcomes (PROs) followin...περισσότερα »
A cortical thickness and radiation dose mapping approach identifies early thinning of ribs after stereotactic body radiation therapy
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 9 April 2016 *Source:*Radiotherapy and Oncology Author(s): Catherine Okoukoni, Sarah K. Lynch, Emory R. McTyre, David M. Randolph, Ashley A. Weaver, A. William Blackstock, Brian E. Lally, Michael T Munley, Jeffrey S. Willey Background and PurposeHigh rates of spontaneous rib fractures are associated with thoracic stereotactic body radiation therapy (SBRT). These fractures likely originate within the cortical bone and relate to the cortical thickness (Ct.Th). We report the development and application of a novel Ct.Th and radiation dose mapping techn...περισσότερα »
Risk Factors for Ischemic Complications following Pipeline Embolization Device Treatment of Intracranial Aneurysms: Results from the IntrePED Study [INTERVENTIONAL]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Risk factors for acute ischemic stroke following flow-diverter treatment of intracranial aneurysms are poorly understood. Using the International Retrospective Study of Pipeline Embolization Device (IntrePED) registry, we studied demographic, aneurysm, and procedural characteristics associated with postoperative acute ischemic stroke following Pipeline Embolization Device (PED) treatment. MATERIALS AND METHODS: We identified patients in the IntrePED registry with post-PED-treatment acute ischemic stroke. The rate of postoperative acute ischemic stroke was...περισσότερα »
Widespread Focal Cortical Alterations in Autism Spectrum Disorder with Intellectual Disability Detected by Threshold-Free Cluster Enhancement [PEDIATRICS]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: In the past decades, a large body of work aimed at investigating brain structural anomalies accrued in autism spectrum disorder. Autism spectrum disorder is associated with intellectual disability in up to 50% of cases. However, only a few neuroimaging studies were conducted in autism spectrum disorder with intellectual disability, and none of them benefited from a nonsyndromic intellectual disability control group. MATERIALS AND METHODS: We performed a voxelwise investigation of the structural alterations in 25 children with autism spectrum disorder with... περισσότερα »
Gray Matter Growth Is Accompanied by Increasing Blood Flow and Decreasing Apparent Diffusion Coefficient during Childhood [PEDIATRICS]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Normal values of gray matter volume, cerebral blood flow, and water diffusion have not been established for healthy children. We sought to determine reference values for age-dependent changes of these parameters in healthy children. MATERIALS AND METHODS: We retrospectively reviewed MR imaging data from 100 healthy children. Using an atlas-based approach, age-related normal values for regional CBF, apparent diffusion coefficient, and volume were determined for the cerebral cortex, hippocampus, thalamus, caudate, putamen, globus pallidus, amygdala, and nu... περισσότερα »
Cochlear Implants
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
British Cochlear Implant Group Contralateral acoustic hearing aid use in adult unilateral cochlear implant recipients: Current provision, practice, and clinical experience in the UK. Fielden Ca, Kitterick Pt · Friday, April 15, 2016, 18:35 *Contralateral acoustic hearing aid use in adult unilateral cochlear implant recipients: Current provision, practice, and clinical experience in the UK.* Cochlear Implants Int. 2016 Apr 6;:1-14 Authors: Fielden CA, Kitterick PT Abstract OBJECTIVES: The study surveyed practising cochlear implant (CI) audiologists with the aim of: (1) characterizing UK ... περισσότερα »
Mast cells in lymphomas
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Mast cells in lymphomas*Source:*Critical Reviews in Oncology/Hematology Author(s): Domenico Ribatti Tumor microenvironment is involved in the pathogenesis and progression of human lymphomas. The lymphoma microenvironment is composed by stromal cells, immune cells (macrophages, plasma cells, mast cells, eosinophils, basophils, T- and B-cells), blood vessels and extracellular matrix proteins. This article is focused on the role of mast cells in lymphoma progression and angiogenesis. Mast cells might be regarded in a future perspective as a new target for the adjuvant treatment of tumor...περισσότερα »
Geometric Parameter Analysis of Ruptured and Unruptured Aneurysms in Patients with Symmetric Bilateral Intracranial Aneurysms: A Multicenter CT Angiography Study [INTERVENTIONAL]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Previous studies of geometric and morphologic parameters of intracranial aneurysms have been conducted to determine rupture risk, which remains incompletely defined due to patient-specific risk factors, such as sex, hypertension, and age. To this end, we compared characteristics of ruptured and unruptured aneurysms in the same patients with symmetric bilateral intracranial aneurysms. MATERIALS AND METHODS: Between January 2008 and March 2014, 2361 patients with 2674 aneurysms were diagnosed by CT angiography or surgical findings at 4 medical centers. Geo... περισσότερα »
Suspected Metallic Embolism following Endovascular Treatment of Intracranial Aneurysms [INTERVENTIONAL]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
SUMMARY: We describe a case series of suspected metallic embolism after coil embolization for intracranial aneurysms. Between January 2012 and December 2014, 110 intracranial aneurysms had been treated by coil embolization in our institution. In 6 cases, the postprocedural MR imaging revealed abnormal spotty lesions not detected on the preprocedural MR imaging. The lesions were also undetectable on the postprocedural CT scan. They were demonstrated as low-intensity spots on T1WI, T2WI, DWI, and T2*-weighted imaging. On DWI, they were accompanied by bright "halo," and on T2*-weig...περισσότερα »
Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA [EXTRACRANIAL VASCULAR]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Carotid intraplaque hemorrhage is associated with stroke, plaque thickness, stenosis, ulceration, and adventitial inflammation. Conflicting data exist on whether calcification is a marker of plaque instability, and no data exist on adventitial calcification. Our goal was to determine whether adventitial calcification and soft plaque (a rim sign) help predict carotid intraplaque hemorrhage. MATERIALS AND METHODS: This was a retrospective cohort study of 96 patients who underwent carotid MRA and CTA within 1 month, from 2009 to 2016. We excluded occlusions ... περισσότερα »
Contrast-Enhanced and Time-of-Flight MRA at 3T Compared with DSA for the Follow-Up of Intracranial Aneurysms Treated with the WEB Device [INTERVENTIONAL]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Imaging follow-up at 3T of intracranial aneurysms treated with the WEB Device has not been evaluated yet. Our aim was to assess the diagnostic accuracy of 3D–time-of-flight MRA and contrast-enhanced MRA at 3T against DSA, as the criterion standard, for the follow-up of aneurysms treated with the Woven EndoBridge (WEB) system. MATERIALS AND METHODS: From June 2011 to December 2014, patients treated with the WEB in our institution, then followed for ≥6 months after treatment by MRA at 3T (3D-TOF-MRA and contrast-enhanced MRA) and DSA within 48 hours were i... περισσότερα »
Endovascular Treatment versus Best Medical Treatment in Patients with Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials [ADULT BRAIN]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Endovascular treatment has emerged as a minimally invasive technique for patients with acute ischemic stroke to achieve recanalization. Our aim was to determine the effects of endovascular treatment on clinical and safety outcomes compared with best medical treatment. MATERIALS AND METHODS: Fifteen randomized trials that compared endovascular treatment with best medical treatment in patients with acute ischemic stroke met the inclusion criteria. We calculated pooled odds ratios and 95% CIs by using random-effects models. The primary end point was a favora... περισσότερα »
Normal Developmental Globe Morphology on Fetal MR Imaging [PEDIATRICS]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Age-dependent structural changes of the globes occur during gestation. The posterolateral globe margins bulge outward, and the eyes are conical in early gestation. Later, the globes are ellipsoid. The purpose of this study was to establish normal developmental fetal globe morphology. MATERIALS AND METHODS: The fetal MR imaging data base at an academic children's hospital was queried for all brain MRIs performed during 8 years. Motion artifacts, brain/craniofacial/globe malformations, and chromosomal defects were exclusion criteria. Two board-certified neu... περισσότερα »
Association of Automatically Quantified Total Blood Volume after Aneurysmal Subarachnoid Hemorrhage with Delayed Cerebral Ischemia [ADULT BRAIN]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: The total amount of extravasated blood after aneurysmal subarachnoid hemorrhage, assessed with semiquantitative methods such as the modified Fisher and Hijdra scales, is known to be a predictor of delayed cerebral ischemia. However, prediction rates of delayed cerebral ischemia are moderate, which may be caused by the rough and observer-dependent blood volume estimation used in the prediction models. We therefore assessed the association between automatically quantified total blood volume on NCCT and delayed cerebral ischemia. MATERIALS AND METHODS: We r... περισσότερα »
WEB Treatment of Ruptured Intracranial Aneurysms [INTERVENTIONAL]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: The Woven EndoBridge (WEB) device was recently introduced for intrasaccular treatment of wide-neck aneurysms without the need for adjunctive support. We present our first experience in using the WEB for small ruptured aneurysms. MATERIALS AND METHODS: During 11 months, 32 of 71 (45%) endovascularly treated acutely ruptured aneurysms were treated with the WEB. The patients were 12 men and 20 women, with a mean age of 61 years (range, 34–84 years). The mean aneurysm size was 4.9 mm, and 14 were ≤4 mm. Of 32 aneurysms, 24 (75%) had a wide neck. RESULTS: Al... περισσότερα »
American Journal of Audiology
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
American Journal of Audiology Current Issue Outcomes of an International Audiology Service-Learning Study-Abroad Program Krishnan La, Richards Kr, Simpson Jm. · Thursday, March 24, 2016, 6:34 Purpose The purpose of this study was to evaluate students' academic and civic learning, with particular interest in cultural competence, gained through participation in the Speech, Language, and Hearing Sciences in Zambia study-abroad program. Method Twelve female students participated in the program. Quantitative data collected included pre- and postprogram administration of the Public Affairs S... περισσότερα »
Allergologia et Immunopathologia
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Allergologia et Immunopathologia Ovalbumin-induced allergic inflammation lead to structural alterations in mouse model and protective effects of intranasal curcumin: A comparative study Saturday, April 02, 2016, 17:56 Publication date: Available online 1 April 2016 *Source:*Allergologia et Immunopathologia Author(s): Subhashini, P.S. Chauhan, R. Singh Background Antigen exposure and persistent inflammation leads to structural changes in the asthmatic airways which are collectively termed as “airway remodelling”. Presently available asthma medications ameliorate inflammations but are un... περισσότερα »
Pituitary metastases from papillary carcinoma of thyroid
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
'Endocrine Cancers' : a case report and literature review Anthony Russell · Friday, April 22, 2016, 6:35 Summary Metastases to the pituitary gland are an uncommon complication of thyroid cancer. They resemble pituitary neoplasms posing a diagnostic challenge. We present a case of an aggressive non-radioiodine avid papillary thyroid cancer with recurrent pituitary metastases and a review of the literature. A 70-year-old woman with a history of papillary thyroid cancer and bony metastases presented with symptoms of hypoadrenalism and peripheral vision loss. Magnetic resonance imaging s... περισσότερα »
Adrenal cancer in neurofibromatosis type 1
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
'Endocrine Cancers' - EDM Case Reports Search : case report and DNA analysis Teng-teng L L Chung · Friday, April 22, 2016, 6:35 Summary Adrenal cortical carcinoma (ACC) has previously only been reported in eight patients with type 1 neurofibromatosis (NF1). There has not been any clear evidence of a causal association between *NF1* gene mutations and adrenocortical malignancy development. We report the case of a 49-year-old female, with no family history of endocrinopathy, who was diagnosed with ACC on the background of NF1, due to a novel germline frame shift mutation (c.5452_5453del... περισσότερα »
Parasitic thyroid nodules: cancer or not?
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
'Endocrine Cancers' Bronwyn A Crawford · Friday, April 22, 2016, 6:35 Summary In 2006, a 58-year-old woman presented with thyrotoxicosis. She had undergone left hemithyroidectomy 14 years before for a benign follicular adenoma. Ultrasound imaging demonstrated bilateral cervical lymphadenopathy with enhanced tracer uptake in the left lateral neck on a Technetium-99m uptake scan. Fine-needle aspiration biopsy of a left lateral neck node was insufficient for a cytological diagnosis; however, thyroglobulin (Tg) washings were strongly positive. The clinical suspicion was of functionally ...περισσότερα »
Zebrafish and mice and bears
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
The microbiome of hibernating bears, and zebrafish as a model for bacterial sepsis feature in this animal-centric episode of TWiM hosted by Vincent, Michael, and Michele. Image: Bright-field (top) and fluorescent (bottom) images of zebrafish embryos infected with E. coli strain F11. E... from Infection via ola Kala on Inoreader http://ift.tt/1qFRpnC via IFTTT
Thermotransduction and heat stress in dental structures during orthodontic debonding
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα
Abstract Objectives Recent studies have indicated possible thermal damage to pulpal tissue during orthodontic debonding. This study aimed to analyze the thermal loads acting upon dental structures and their transfer to the pulp during orthodontic debonding. Specific goals were to analyze temperature changes in local dental tissues, thermotransduction to the pulp cavity, and the effectiveness of common cooling strategies and of simulated intrapulpal circulation. Materials and methods Metal brackets were bonded to five extracted human molars and subsequently removed. While a carbid... περισσότερα »
Dental Anesthesia
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα
The post Dental Anesthesia appeared first on Family Dentistry and Cosmetic Surgery Clinic. from #Dental via xlomafota13 on Inoreader http://ift.tt/1TlZxTL via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Widespread Focal Cortical Alterations in Autism Spectrum Disorder with Intellectual Disability Detected by Threshold-Free Cluster Enhancement [PEDIATRICS]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: In the past decades, a large body of work aimed at investigating brain structural anomalies accrued in autism spectrum disorder. Autism spectrum disorder is associated with intellectual disability in up to 50% of cases. However, only a few neuroimaging studies were conducted in autism spectrum disorder with intellectual disability, and none of them benefited from a nonsyndromic intellectual disability control group. MATERIALS AND METHODS: We performed a voxelwise investigation of the structural alterations in 25 children with autism spectrum disorder with... περισσότερα »
Gray Matter Growth Is Accompanied by Increasing Blood Flow and Decreasing Apparent Diffusion Coefficient during Childhood [PEDIATRICS]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Normal values of gray matter volume, cerebral blood flow, and water diffusion have not been established for healthy children. We sought to determine reference values for age-dependent changes of these parameters in healthy children. MATERIALS AND METHODS: We retrospectively reviewed MR imaging data from 100 healthy children. Using an atlas-based approach, age-related normal values for regional CBF, apparent diffusion coefficient, and volume were determined for the cerebral cortex, hippocampus, thalamus, caudate, putamen, globus pallidus, amygdala, and nu... περισσότερα »
Geometric Parameter Analysis of Ruptured and Unruptured Aneurysms in Patients with Symmetric Bilateral Intracranial Aneurysms: A Multicenter CT Angiography Study [INTERVENTIONAL]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Previous studies of geometric and morphologic parameters of intracranial aneurysms have been conducted to determine rupture risk, which remains incompletely defined due to patient-specific risk factors, such as sex, hypertension, and age. To this end, we compared characteristics of ruptured and unruptured aneurysms in the same patients with symmetric bilateral intracranial aneurysms. MATERIALS AND METHODS: Between January 2008 and March 2014, 2361 patients with 2674 aneurysms were diagnosed by CT angiography or surgical findings at 4 medical centers. Geo... περισσότερα »
Suspected Metallic Embolism following Endovascular Treatment of Intracranial Aneurysms [INTERVENTIONAL]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
SUMMARY: We describe a case series of suspected metallic embolism after coil embolization for intracranial aneurysms. Between January 2012 and December 2014, 110 intracranial aneurysms had been treated by coil embolization in our institution. In 6 cases, the postprocedural MR imaging revealed abnormal spotty lesions not detected on the preprocedural MR imaging. The lesions were also undetectable on the postprocedural CT scan. They were demonstrated as low-intensity spots on T1WI, T2WI, DWI, and T2*-weighted imaging. On DWI, they were accompanied by bright "halo," and on T2*-weig...περισσότερα »
Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA [EXTRACRANIAL VASCULAR]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Carotid intraplaque hemorrhage is associated with stroke, plaque thickness, stenosis, ulceration, and adventitial inflammation. Conflicting data exist on whether calcification is a marker of plaque instability, and no data exist on adventitial calcification. Our goal was to determine whether adventitial calcification and soft plaque (a rim sign) help predict carotid intraplaque hemorrhage. MATERIALS AND METHODS: This was a retrospective cohort study of 96 patients who underwent carotid MRA and CTA within 1 month, from 2009 to 2016. We excluded occlusions ... περισσότερα »
Contrast-Enhanced and Time-of-Flight MRA at 3T Compared with DSA for the Follow-Up of Intracranial Aneurysms Treated with the WEB Device [INTERVENTIONAL]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Imaging follow-up at 3T of intracranial aneurysms treated with the WEB Device has not been evaluated yet. Our aim was to assess the diagnostic accuracy of 3D–time-of-flight MRA and contrast-enhanced MRA at 3T against DSA, as the criterion standard, for the follow-up of aneurysms treated with the Woven EndoBridge (WEB) system. MATERIALS AND METHODS: From June 2011 to December 2014, patients treated with the WEB in our institution, then followed for ≥6 months after treatment by MRA at 3T (3D-TOF-MRA and contrast-enhanced MRA) and DSA within 48 hours were i... περισσότερα »
Endovascular Treatment versus Best Medical Treatment in Patients with Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials [ADULT BRAIN]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Endovascular treatment has emerged as a minimally invasive technique for patients with acute ischemic stroke to achieve recanalization. Our aim was to determine the effects of endovascular treatment on clinical and safety outcomes compared with best medical treatment. MATERIALS AND METHODS: Fifteen randomized trials that compared endovascular treatment with best medical treatment in patients with acute ischemic stroke met the inclusion criteria. We calculated pooled odds ratios and 95% CIs by using random-effects models. The primary end point was a favora... περισσότερα »
Normal Developmental Globe Morphology on Fetal MR Imaging [PEDIATRICS]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Age-dependent structural changes of the globes occur during gestation. The posterolateral globe margins bulge outward, and the eyes are conical in early gestation. Later, the globes are ellipsoid. The purpose of this study was to establish normal developmental fetal globe morphology. MATERIALS AND METHODS: The fetal MR imaging data base at an academic children's hospital was queried for all brain MRIs performed during 8 years. Motion artifacts, brain/craniofacial/globe malformations, and chromosomal defects were exclusion criteria. Two board-certified neu... περισσότερα »
Association of Automatically Quantified Total Blood Volume after Aneurysmal Subarachnoid Hemorrhage with Delayed Cerebral Ischemia [ADULT BRAIN]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: The total amount of extravasated blood after aneurysmal subarachnoid hemorrhage, assessed with semiquantitative methods such as the modified Fisher and Hijdra scales, is known to be a predictor of delayed cerebral ischemia. However, prediction rates of delayed cerebral ischemia are moderate, which may be caused by the rough and observer-dependent blood volume estimation used in the prediction models. We therefore assessed the association between automatically quantified total blood volume on NCCT and delayed cerebral ischemia. MATERIALS AND METHODS: We r... περισσότερα »
Risk Factors for Ischemic Complications following Pipeline Embolization Device Treatment of Intracranial Aneurysms: Results from the IntrePED Study [INTERVENTIONAL]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Risk factors for acute ischemic stroke following flow-diverter treatment of intracranial aneurysms are poorly understood. Using the International Retrospective Study of Pipeline Embolization Device (IntrePED) registry, we studied demographic, aneurysm, and procedural characteristics associated with postoperative acute ischemic stroke following Pipeline Embolization Device (PED) treatment. MATERIALS AND METHODS: We identified patients in the IntrePED registry with post-PED-treatment acute ischemic stroke. The rate of postoperative acute ischemic stroke was...περισσότερα »
WEB Treatment of Ruptured Intracranial Aneurysms [INTERVENTIONAL]
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
BACKGROUND AND PURPOSE: The Woven EndoBridge (WEB) device was recently introduced for intrasaccular treatment of wide-neck aneurysms without the need for adjunctive support. We present our first experience in using the WEB for small ruptured aneurysms. MATERIALS AND METHODS: During 11 months, 32 of 71 (45%) endovascularly treated acutely ruptured aneurysms were treated with the WEB. The patients were 12 men and 20 women, with a mean age of 61 years (range, 34–84 years). The mean aneurysm size was 4.9 mm, and 14 were ≤4 mm. Of 32 aneurysms, 24 (75%) had a wide neck. RESULTS: Al... περισσότερα »
Functional Maps at the Onset of Auditory Inputs in Very Early Preterm Human Neonates
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
During the last trimester of human gestation, neurons reach their final destination and establish long- and short-distance connections. Due to the difficulties obtaining functional data at this age, the characteristics of the functional architecture at the onset of sensory thalamocortical connectivity in humans remain largely unknown. In particular, it is unknown to what extent responses evoked by an external stimulus are general or already sensitive to certain stimuli. In the present study, we recorded high-density event-related potentials (ERPs) in 19 neonates, tested ten weeks ... περισσότερα »
The Value of Vocal Extent Measure (VEM) Assessing Phonomicrosurgical Outcomes in Vocal Fold Polyps
Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 1 ώρα
This study aimed to present vocal extent measure (VEM), demonstrate its changes with phonomicrosurgical treatment in patients with vocal fold polyps (VFPs), and to compare its performance to that of established vocal parameters. from Speech via xlomafota13 on Inoreader http://ift.tt/1YJK5Ch
Rare skin manifestations successfully treated with primary B-cell chronic lymphocytic leukemia treatment
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/22Sgnwj via IFTTT
Lower Parietal Encoding Activation Is Associated with Sharper Information and Better Memory
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Mean fMRI activation in ventral posterior parietal cortex (vPPC) during memory encoding often negatively predicts successful remembering. A popular interpretation of this phenomenon is that vPPC reflects "off-task" processing. However, recent fMRI studies considering distributed patterns of activity suggest that vPPC actively represents encoded material. Here, we assessed the relationships between pattern-based content representations in vPPC, mean activation in vPPC, and subsequent remembering. We analyzed data from two fMRI experiments where subjects studied then recalled word–f...περισσότερα »
Functional Differentiation of Cholecystokinin-Containing Interneurons Destined for the Cerebral Cortex
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Although extensively studied postnatally, the functional differentiation of cholecystokinin (CCK)-containing interneurons en route towards the cerebral cortex during fetal development is incompletely understood. Here, we used CCKBAC/DsRed mice encoding a CCK promoter-driven red fluorescent protein to analyze the temporal dynamics of DsRed expression, neuronal identity, and positioning through high-resolution developmental neuroanatomy. Additionally, we developed a dual reporter mouse line (CCKBAC/DsRed::GAD67 gfp/+) to differentiate CCK-containing interneurons from DsRed+ principal ...περισσότερα »
Network-Level Structure-Function Relationships in Human Neocortex
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
The dynamics of spontaneous fluctuations in neural activity are shaped by underlying patterns of anatomical connectivity. While numerous studies have demonstrated edge-wise correspondence between structural and functional connections, much less is known about how large-scale coherent functional network patterns emerge from the topology of structural networks. In the present study, we deploy a multivariate statistical technique, partial least squares, to investigate the association between spatially extended structural networks and functional networks. We find multiple statistically...περισσότερα »
Widespread Focal Cortical Alterations in Autism Spectrum Disorder with Intellectual Disability Detected by Threshold-Free Cluster Enhancement PEDIATRICS
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
BACKGROUND AND PURPOSE: In the past decades, a large body of work aimed at investigating brain structural anomalies accrued in autism spectrum disorder. Autism spectrum disorder is associated with intellectual disability in up to 50% of cases. However, only a few neuroimaging studies were conducted in autism spectrum disorder with intellectual disability, and none of… Continue reading Widespread Focal Cortical Alterations in Autism Spectrum Disorder with Intellectual Disability Detected by Threshold-Free Cluster Enhancement PEDIATRICS
Gray Matter Growth Is Accompanied by Increasing Blood Flow and Decreasing Apparent Diffusion Coefficient during Childhood PEDIATRICS
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Normal values of gray matter volume, cerebral blood flow, and water diffusion have not been established for healthy children. We sought to determine reference values for age-dependent changes of these parameters in healthy children. MATERIALS AND METHODS: We retrospectively reviewed MR imaging data from 100 healthy children. Using an atlas-based approach, age-related… Continue reading Gray Matter Growth Is Accompanied by Increasing Blood Flow and Decreasing Apparent Diffusion Coefficient during Childhood PEDIATRICS
Geometric Parameter Analysis of Ruptured and Unruptured Aneurysms in Patients with Symmetric Bilateral Intracranial Aneurysms: A Multicenter CT Angiography Study INTERVENTIONAL
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Previous studies of geometric and morphologic parameters of intracranial aneurysms have been conducted to determine rupture risk, which remains incompletely defined due to patient-specific risk factors, such as sex, hypertension, and age. To this end, we compared characteristics of ruptured and unruptured aneurysms in the same patients with symmetric bilateral intracranial aneurysms.… Continue reading Geometric Parameter Analysis of Ruptured and Unruptured Aneurysms in Patients with Symmetric Bilateral Intracranial Aneurysms: A Multicenter CT Angiography Stud... περισσότερα »
Suspected Metallic Embolism following Endovascular Treatment of Intracranial Aneurysms INTERVENTIONAL
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
SUMMARY: We describe a case series of suspected metallic embolism after coil embolization for intracranial aneurysms. Between January 2012 and December 2014, 110 intracranial aneurysms had been treated by coil embolization in our institution. In 6 cases, the postprocedural MR imaging revealed abnormal spotty lesions not detected on the preprocedural MR imaging. The lesions were… Continue reading Suspected Metallic Embolism following Endovascular Treatment of Intracranial Aneurysms INTERVENTIONAL
Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA EXTRACRANIAL VASCULAR
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Carotid intraplaque hemorrhage is associated with stroke, plaque thickness, stenosis, ulceration, and adventitial inflammation. Conflicting data exist on whether calcification is a marker of plaque instability, and no data exist on adventitial calcification. Our goal was to determine whether adventitial calcification and soft plaque (a rim sign) help predict carotid intraplaque hemorrhage.… Continue reading Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA EXTRACRANIAL VASCULAR
Contrast-Enhanced and Time-of-Flight MRA at 3T Compared with DSA for the Follow-Up of Intracranial Aneurysms Treated with the WEB Device INTERVENTIONAL
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Imaging follow-up at 3T of intracranial aneurysms treated with the WEB Device has not been evaluated yet. Our aim was to assess the diagnostic accuracy of 3D–time-of-flight MRA and contrast-enhanced MRA at 3T against DSA, as the criterion standard, for the follow-up of aneurysms treated with the Woven EndoBridge (WEB) system. MATERIALS… Continue reading Contrast-Enhanced and Time-of-Flight MRA at 3T Compared with DSA for the Follow-Up of Intracranial Aneurysms Treated with the WEB Device INTERVENTIONAL
Endovascular Treatment versus Best Medical Treatment in Patients with Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials ADULT BRAIN
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Endovascular treatment has emerged as a minimally invasive technique for patients with acute ischemic stroke to achieve recanalization. Our aim was to determine the effects of endovascular treatment on clinical and safety outcomes compared with best medical treatment. MATERIALS AND METHODS: Fifteen randomized trials that compared endovascular treatment with best medical treatment… Continue reading Endovascular Treatment versus Best Medical Treatment in Patients with Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials ADULT BRAIN
Normal Developmental Globe Morphology on Fetal MR Imaging PEDIATRICS
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Age-dependent structural changes of the globes occur during gestation. The posterolateral globe margins bulge outward, and the eyes are conical in early gestation. Later, the globes are ellipsoid. The purpose of this study was to establish normal developmental fetal globe morphology. MATERIALS AND METHODS: The fetal MR imaging data base at an… Continue reading Normal Developmental Globe Morphology on Fetal MR Imaging PEDIATRICS
Association of Automatically Quantified Total Blood Volume after Aneurysmal Subarachnoid Hemorrhage with Delayed Cerebral Ischemia ADULT BRAIN
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
BACKGROUND AND PURPOSE: The total amount of extravasated blood after aneurysmal subarachnoid hemorrhage, assessed with semiquantitative methods such as the modified Fisher and Hijdra scales, is known to be a predictor of delayed cerebral ischemia. However, prediction rates of delayed cerebral ischemia are moderate, which may be caused by the rough and observer-dependent blood volume… Continue reading Association of Automatically Quantified Total Blood Volume after Aneurysmal Subarachnoid Hemorrhage with Delayed Cerebral Ischemia ADULT BRAIN
Risk Factors for Ischemic Complications following Pipeline Embolization Device Treatment of Intracranial Aneurysms: Results from the IntrePED Study INTERVENTIONAL
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
BACKGROUND AND PURPOSE: Risk factors for acute ischemic stroke following flow-diverter treatment of intracranial aneurysms are poorly understood. Using the International Retrospective Study of Pipeline Embolization Device (IntrePED) registry, we studied demographic, aneurysm, and procedural characteristics associated with postoperative acute ischemic stroke following Pipeline Embolization Device (PED) treatment. MATERIALS AND METHODS: We identified patients in… Continue reading Risk Factors for Ischemic Complications following Pipeline Embolization Device Treatment of Intracranial A...περισσότερα »
Is it possible to improve communication around radiotherapy delivery: A randomized study to assess the efficacy of team training?
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 9 April 2016 *Source:*Radiotherapy and Oncology Author(s): Aurore Liénard, France Delevallez, Darius Razavi, Anne-Sophie Gibon, Yves Libert, Nicole Delvaux, Serge Marchal, Anne-Marie Etienne, Isabelle Bragard, Christine Reynaert, Jean-Louis Slachmuylder, Jean-François Durieux, Christine Farvacques, Pierre Scalliet, Paul Van Houtte, Philippe Coucke, Isabelle Merckaert Background and purposeThe aim of this study was to assess the efficacy of a 38-h communication skills training program designed for multidisciplinary radiotherapy teams.Materials and m...περισσότερα »
Effects of local irradiation combined with sunitinib on early remodeling mitochondria and oxidative stress in the rat heart
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 9 April 2016 *Source:*Radiotherapy and Oncology Author(s): Vijayalakshmi Sridharan, Chanice J. Thomas, Maohua Cao, Stepan B. Melnyk, Oleksandra Pavliv, Jacob Joseph, Sharda P. Singh, Sunil Sharma, Eduardo G. Moros, Marjan Boerma Background and purposeThoracic (chemo)radiation therapy is increasingly administered with tyrosine kinase inhibitors (TKI). While TKI have adverse effects on the heart, it is unknown whether combination with other cancer therapies causes enhanced toxicity. We used an animal model to investigate whether radiation and sunitin...περισσότερα »
Planned versus delivered bladder dose reconstructed using solid and hollow organ models during prostate cancer IMRT
Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
Publication date: Available online 9 April 2016 *Source:*Radiotherapy and Oncology Author(s): Tara Rosewall, Janelle Wheat, Geoffrey Currie, Vickie Kong, Andrew J. Bayley, Joanne Moseley, Peter Chung, Charles Catton, Tim Craig, Michael Milosevic Background and purposeAll studies to date have evaluated the dosimetric effect of bladder deformation using an organ model that includes the dose to the urine. This research reconstructed bladder dose using both hollow and solid organ models, to determine if dose/volume differences exist.Materials and methods35 prostate IMRT patients were se...περισσότερα »
Rare skin manifestations successfully treated with primary B-cell chronic lymphocytic leukemia treatment
Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/22Sgnwj via IFTTT
Rare skin manifestations successfully treated with primary B-cell chronic lymphocytic leukemia treatment
Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/22Sgnwj via IFTTT
The beneficial effects of a positive attention bias amongst children with a history of psychosocial deprivation
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρες
[image: alertIcon.gif] Publication date: Available online 21 April 2016 *Source:*Biological Psychology Author(s): Sonya Troller-Renfree, Katie A. McLaughlin, Margaret A. Sheridan, Charles A. Nelson, Charles H. Zeanah, Nathan A. Fox Children raised in institutions experience psychosocial deprivation that has detrimental influences on attention and mental health. The current study examined patterns of attention biases in children from institutions who were randomized at approximately 21.6 months to receive either a high-quality foster care intervention or care-as-usual. At age 12, chil... περισσότερα »
Comment on Z-score reference ranges for normal fetal heart sizes throughout pregnancy derived from fetal echocardiography
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρες
from #Medicine via ola Kala on Inoreader http://ift.tt/1Sxw0qb Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Cover Image Volume 36 Issue 4
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρες
[image: Thumbnail image of graphical abstract] Magnetic resonance images of a human embryonic brain at Carnegie stage 23, from Kobayashi *et al*., *Prenat Diagn* *36*:338–345, DOI: 10.1002/pd.4786. from #Medicine via ola Kala on Inoreader http://ift.tt/26ieyNu Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Assessment of morbidity following regional nodal dissection in the axilla and groin for metastatic melanoma
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 2 ώρες
Background This study assessed and compared the morbidity of nodal dissection in the axilla and groin including sentinel lymph node biopsy (SLNB), completion lymph node dissection for a positive SLNB (CLND) and therapeutic lymph node dissection (TLND) with and without adjuvant radiotherapy (RT). Methods Patients who had nodal dissection in the axilla or groin for cutaneous melanoma over an 18-year period (1995–2013) were prospectively documented on a database. The median follow-up was nearly 3 years. Early complications and clinically relevant lymphoedema were retrospectively ana...περισσότερα »
Endovascular stent grafting of a thoracic aortic mobile thrombus with embolic phenomenon
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 2 ώρες
from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1VFlUYl via IFTTT
Three-dimensional segmentation of retroperitoneal masses using continuous convex relaxation and accumulated gradient distance for radiotherapy planning
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 2 ώρες
Abstract An innovative algorithm has been developed for the segmentation of retroperitoneal tumors in 3D radiological images. This algorithm makes it possible for radiation oncologists and surgeons semiautomatically to select tumors for possible future radiation treatment and surgery. It is based on continuous convex relaxation methodology, the main novelty being the introduction of accumulated gradient distance, with intensity and gradient information being incorporated into the segmentation process. The algorithm was used to segment 26 CT image volumes. The results were compared ...περισσότερα »
Antioxidative/oxidative effects and retarding osteoconductivity of ciprofloxacin-loaded porous polyvinyl alcohol/bioactive glass hybrid
Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 2 ώρες
Abstract This study investigated the effect of bioglass (melting)-polyvinyl alcohol (BG (M)-PVA) and bioglass (melting)-polyvinyl alcohol-20 %ciprofloxacin (BG(M)-PVA-20Cip) in improving antioxidant activity and regenerating bone capacity. These composites were implanted in femoral condyles of ovariectomized Wistar rats and compared to that of controls groups. After the different period of implantation (15, 30, 60 and 90 days), the treatment of ovariectomized rats with BG(M)-PVA-20Cip showed a significantly higher malondialdehyde concentration when compared to that of BG(M)-PVA gr...περισσότερα »
Plasma ceramide a real-time predictive marker of pulmonary and hepatic metastases response to stereotactic body radiation therapy combined with irinotecan
Alexandros G. SfakianakisστοRathiotherapy by Alexandros G. SfakianakisΠριν από 2 ώρες
[image: gr1.sml] Early biomarkers of tumour response are needed to discriminate between responders and non-responders to radiotherapy. We evaluated the ability of ceramide, a bioactive sphingolipid, to predict tumour sensitivity in patients treated by hypofractionated stereotactic body radiation therapy (SBRT) combined with irinotecan chemotherapy. from Rathiotherapy via xlomafota13 on Inoreader http://ift.tt/1VJSBTQ
Image guided adaptive brachytherapy with combined intracavitary and interstitial technique improves the therapeutic ratio in locally advanced cervical cancer: Analysis from the retroEMBRACE study
Alexandros G. SfakianakisστοRathiotherapy by Alexandros G. SfakianakisΠριν από 2 ώρες
[image: gr1.sml] Image guided adaptive brachytherapy (IGABT) using intracavitary applicators (IC) has led to a significant improvement of local control in locally advanced cervical cancer (LACC). Further improvement has been obtained with combined intracavitary/interstitial (IC/IS) applicators. The aim of this analysis was to evaluate the impact on local control and late morbidity of application of combined IS/IC brachytherapy in a large multicentre population. from Rathiotherapy via xlomafota13 on Inoreader http://ift.tt/1VJSBTM
The effect of radiotherapy and radiotherapy combined with bisphosphonates or RANK ligand inhibitors on bone quality in bone metastases. A systematic review
Alexandros G. SfakianakisστοRathiotherapy by Alexandros G. SfakianakisΠριν από 2 ώρες
[image: gr1.sml] The role of radiotherapy in stabilizing metastatic bones is unclear. This systematic review assessed the effects of (1) radiotherapy, (2) radiotherapy combined with bisphosphonates, and (3) radiotherapy combined with RANK ligand (RANKL) inhibitors on bone quality and bone strength in bone metastases originating from solid tumors. from Rathiotherapy via xlomafota13 on Inoreader http://ift.tt/1VJSB6h
Management of chemo/radiation-induced oral mucositis in patients with head and neck cancer: A review of the current literature
Alexandros G. SfakianakisστοRathiotherapy by Alexandros G. SfakianakisΠριν από 2 ώρες
Oropharyngeal mucositis is an important complication in non-surgical cancer treatments. It represents the major complication in radiotherapy of tumors located in head and neck areas. Many results have been published in order to define the best clinical protocol for prophylaxis or treatment of mucositis, but a consensus has not been attained yet. In this review, some recent topics in prophylaxis and treatment of mucositis related to radiation therapy are reconsidered using PUBMED and GOOGLE SCHOOLAR search engines from 2000 to 2015. from Rathiotherapy via xlomafota13 on Inoreader htt... περισσότερα »
Scutellarin as a Potential Therapeutic Agent for Microglia-Mediated Neuroinflammation in Cerebral Ischemia
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 ώρες
Abstract The cerebral ischemia is one of the most common diseases in the central nervous system that causes progressive disability or even death. In this connection, the inflammatory response mediated by the activated microglia is believed to play a central role in this pathogenesis. In the event of brain injury, activated microglia can clear the… Continue reading Scutellarin as a Potential Therapeutic Agent for Microglia-Mediated Neuroinflammation in Cerebral Ischemia
Reconstructing projectile technology during the Pre-Pottery Neolithic B in the Levant: An integrated approach to large tanged points from Halula
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 ώρες
Publication date: May 2016 Source:Journal of Archaeological Science, Volume 69 Author(s): Ferran Borrell, Denis Štefanisko Large tanged points made on bidirectional blades constitute the most characteristic tool type during the Pre-Pottery Neolithic B in the Levant. Studies on projectile typology and on bidirectional technology have revealed important stylistic differences reflecting chronological and geographical patterning, contributing… Continue reading Reconstructing projectile technology during the Pre-Pottery Neolithic B in the Levant: An integrated approach to large tanged po... περισσότερα »
Dynamic assessment of exposure to air pollution using mobile phone data
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 ώρες
Abstract Background Exposure to air pollution can have major health impacts, such as respiratory and cardiovascular diseases. Traditionally, only the air pollution concentration at the home location is taken into account in health impact assessments and epidemiological studies. Neglecting individual travel patterns can lead to a bias in air pollution exposure assessments. Methods In this… Continue reading Dynamic assessment of exposure to air pollution using mobile phone data
Bacillus anthracis Prolyl 4-Hydroxylase Modifies Collagen-like Substrates in Asymmetric Patterns Protein Structure and Folding
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 ώρες
Proline hydroxylation is the most prevalent post-translational modification in collagen. The resulting product trans-4-hydroxyproline (Hyp) is of critical importance for the stability and thus function of collagen, with defects leading to several diseases. Prolyl 4-hydroxylases (P4Hs) are mononuclear non-heme iron α-ketoglutarate (αKG)-dependent dioxygenases that catalyze Hyp formation. While animal and plant P4Hs target peptidyl proline,… Continue reading Bacillus anthracis Prolyl 4-Hydroxylase Modifies Collagen-like Substrates in Asymmetric Patterns Protein Structure and Folding
What is on the Outside Matters: The Role of the Extracellular Polymeric Substance of Gram-negative Biofilms in Evading Host Immunity and as a Target for Therapeutic Intervention Immunology
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 ώρες
Biofilms are organized multicellular communities encased in an extracellular polymeric substance (EPS). Biofilm resident bacteria resist immunity and antimicrobials. The EPS provides structural stability and presents a barrier, however a complete understanding of how EPS structure relates to biological function is lacking. This review focuses on EPS of three Gram-negative pathogens: Pseudomonas aeruginosa, nontypeable Haemophilus… Continue reading What is on the Outside Matters: The Role of the Extracellular Polymeric Substance of Gram-negative Biofilms in Evading Host Immunity and ... περισσότερα »
