Elevated lipoprotein (a) levels predict deep vein thrombosis
Elevated lipoprotein (a) levels predict deep vein thrombosis in acute ischemic stroke patients: Lipoprotein (a) [Lp(a)] plays a crucial role in the pathogenesis of deep vein thrombosis (DVT). The purpose of this study was to investigate whether Lp(a) serum levels at admission could be a risk factor for DVT in Chinese patients with acute ischemic stroke (AIS). A total of 232 patients with AIS were included in the study. The patients were assessed for DVT using colour Doppler ultrasonography. We performed colour Doppler ultrasonography 15 days after the stroke and whenever clinically ... περισσότερα »
Unexpected maspin immunoreactivity in Merkel cell carcinoma
Unexpected maspin immunoreactivity in Merkel cell carcinoma: AbstractMerkel cell carcinoma (MCC) is a rare but aggressive cutaneous neuroendocrine tumor, which multifactorial etiopathogenesis seems to be related to ultraviolet radiation, Merkel cell polyomavirus (MCV), and immunosuppression. In this paper, we present three cases of diagnosed MCC in apparently healthy Caucasians, two of them located in a sun-exposed area. They represented 0.25 % of all cutaneous malignant tumors diagnosed in our department. In the first case, MCC was diagnosed in the frontal region of a 67-year-old ... περισσότερα »
Parathyroid adenoma causing spontaneous cervical hematoma: two case reports
Parathyroid adenoma causing spontaneous cervical hematoma: two case reports: Background: Although spontaneous rupture of a cervical parathyroid adenoma with extracapsular hemorrhage is rare, it may cause cervical and mediastinal hematoma, leading to potentially fatal consequences.Case presentationThe first case was a 76-year-old Asian female who presented with pharyngeal discomfort and anterior chest ecchymosis. Endoscopic investigation showed submucosal hemorrhage in the pharynx and larynx. The second case was a 62-year-old Asian male who presented with anterior chest ecchymosis and... περισσότερα »
Role of postoperative radiation therapy in patients with adenoid cystic carcinoma: a SEER analysis
Role of postoperative radiation therapy in patients with adenoid cystic carcinoma: a SEER analysis: Abstract ObjectivesAdenoid cystic carcinoma (ACC) is a rare malignancy affecting the exocrine glands. Management is surgery plus or minus adjuvant radiation (RT). No prospective study of RT for resected ACC has been reported. We hypothesized that adjuvant RT might improve survival. Methods and materialsThe Surveillance, Epidemiology and End Results Database (SEER) database was queried for ACC cases from 1988 to 2010 (*n* = 3427). A univariate analysis of survival by whether RT wa... περισσότερα »
Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis
Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis: Abstract BackgroundTamoxifen (TAM) is an important cancer therapeutic and an experimental tool for effecting genetic recombination using the inducible Cre-Lox technique. Despite its widespread use in the clinic and laboratory, we know little about its effects on the nervous system. This is of significant concern because TAM, via unknown mechanisms, induces cognitive impairment in humans. A hallmark of cellular stress is induction of Activating Transcription Factor 3 (*Atf3*), and so to det... περισσότερα »
Atypical teratoid rhabdoid tumour (ATRT) is a malignant tumour of the central nervous system
Multimodal therapy in children and adolescents with newly diagnosed atypical teratoid rhabdoid tumor: individual pooled data analysis and review of the literature: AbstractAtypical teratoid rhabdoid tumour (ATRT) is a malignant tumour of the central nervous system with a dismal prognosis. There is no consensus on optimal treatment and different multimodal strategies are currently being used in an attempt to improve outcomes. To evaluate the impact of high-dose chemotherapy followed by autologous stem-cell rescue (HD48 SCR), radiotherapy (RT) at first line, intrathecal chemotherapy ... περισσότερα »
Preliminary study of differentiating smears from cancerous and non-cancerous nasopharyngeal tissue using confocal Raman spectroscopy
Preliminary study of differentiating smears from cancerous and non-cancerous nasopharyngeal tissue using confocal Raman spectroscopy: Abstract PurposeCurrent practice for diagnosing nasopharyngeal carcinoma (NPC) is based on invasive tissue biopsy. This study aims to explore the feasibility of using Raman spectroscopy to differentiate cancerous and non-cancerous nasopharyngeal tissue smears, expecting to realize minimal invasive diagnosis using smears from in vivo mucosa tissue by Raman spectroscopy. MethodsBiopsy tissue smears were acquired from 74 patients with pathologically... περισσότερα »
Divaza (combined preparation, antibodies to brain-specific protein S-100 and eNOS) for Vertigo Prevention in Adults
The Use of Release-Active Antibody-Based Preparations for Vertigo Prevention in Adults: The effectiveness of antibody-based release-active preparations Impaza (antibodies to eNOS), Tenoten (antibodies to brain-specific protein S-100), Dietressa (antibodies to type 1 cannabinoid receptor), Brizantin (combined preparation, antibodies to brain-specific protein S-100 and type 1 cannabinoid receptor), and Divaza (combined preparation, antibodies to brain-specific protein S-100 and eNOS) in the prevention of vertigo was studied on the model of intermittent accumulation of Coriolis accele... περισσότερα »
Brizantin (combined preparation, antibodies to brain-specific protein S-100 and type 1 cannabinoid receptor) for Vertigo Prevention in Adults
The Use of Release-Active Antibody-Based Preparations for Vertigo Prevention in Adults: The effectiveness of antibody-based release-active preparations Impaza (antibodies to eNOS), Tenoten (antibodies to brain-specific protein S-100), Dietressa (antibodies to type 1 cannabinoid receptor), Brizantin (combined preparation, antibodies to brain-specific protein S-100 and type 1 cannabinoid receptor), and Divaza (combined preparation, antibodies to brain-specific protein S-100 and eNOS) in the prevention of vertigo was studied on the model of intermittent accumulation of Coriolis accele... περισσότερα »
Dietressa (antibodies to type 1 cannabinoid receptor) for Vertigo Prevention in Adults
The Use of Release-Active Antibody-Based Preparations for Vertigo Prevention in Adults: The effectiveness of antibody-based release-active preparations Impaza (antibodies to eNOS), Tenoten (antibodies to brain-specific protein S-100), Dietressa (antibodies to type 1 cannabinoid receptor), Brizantin (combined preparation, antibodies to brain-specific protein S-100 and type 1 cannabinoid receptor), and Divaza (combined preparation, antibodies to brain-specific protein S-100 and eNOS) in the prevention of vertigo was studied on the model of intermittent accumulation of Coriolis accele... περισσότερα »
Tenoten (antibodies to brain-specific protein S-100) for Vertigo Prevention in Adults
The Use of Release-Active Antibody-Based Preparations for Vertigo Prevention in Adults: The effectiveness of antibody-based release-active preparations Impaza (antibodies to eNOS), Tenoten (antibodies to brain-specific protein S-100), Dietressa (antibodies to type 1 cannabinoid receptor), Brizantin (combined preparation, antibodies to brain-specific protein S-100 and type 1 cannabinoid receptor), and Divaza (combined preparation, antibodies to brain-specific protein S-100 and eNOS) in the prevention of vertigo was studied on the model of intermittent accumulation of Coriolis accele... περισσότερα »
Impaza (antibodies to eNOS) for Vertigo Prevention in Adults
The Use of Release-Active Antibody-Based Preparations for Vertigo Prevention in Adults: The effectiveness of antibody-based release-active preparations Impaza (antibodies to eNOS), Tenoten (antibodies to brain-specific protein S-100), Dietressa (antibodies to type 1 cannabinoid receptor), Brizantin (combined preparation, antibodies to brain-specific protein S-100 and type 1 cannabinoid receptor), and Divaza (combined preparation, antibodies to brain-specific protein S-100 and eNOS) in the prevention of vertigo was studied on the model of intermittent accumulation of Coriolis accele... περισσότερα »
The Use of Release-Active Antibody-Based Preparations for Vertigo Prevention in Adults
The Use of Release-Active Antibody-Based Preparations for Vertigo Prevention in Adults: The effectiveness of antibody-based release-active preparations Impaza (antibodies to eNOS), Tenoten (antibodies to brain-specific protein S-100), Dietressa (antibodies to type 1 cannabinoid receptor), Brizantin (combined preparation, antibodies to brain-specific protein S-100 and type 1 cannabinoid receptor), and Divaza (combined preparation, antibodies to brain-specific protein S-100 and eNOS) in the prevention of vertigo was studied on the model of intermittent accumulation of Coriolis accele... περισσότερα »
Influence of the interaction between long noncoding RNAs and hypoxia on tumorigenesis
Influence of the interaction between long noncoding RNAs and hypoxia on tumorigenesis: AbstractThe interaction between cancer and its microenvironment is crucial for survival and development of cancerous cells. Tumor microenvironment is usually under hypoxia, which promotes tumor aggressiveness like growth, angiogenesis, and metastasis. How cancer cells respond to hypoxia and the resultant impact on tumorigenesis are not yet fully explored. Long noncoding RNAs (lncRNAs) have been attracting more and more attention since their functions in regulating gene expression at chromatic, t...περισσότερα »
Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma
Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma: AbstractPrimary thyroid lymphoma (PTL) is a rare malignant thyroid tumor; its pathogenesis is closely related to chronic lymphocytic thyroiditis. The different pathological subtypes and stages of PTL have distinct clinical characteristics and prognosis, but the specific reasons are not clear. Wnt5a is a representative protein of non-canonical Wnt signaling. It plays an important role in many different types of tumors. This study is to explore the changes of Wnt5a and its receptor Ror2 in PTL ... περισσότερα »
The immunobiology of myeloid-derived suppressor cells in cancer
The immunobiology of myeloid-derived suppressor cells in cancer: AbstractThe tumor microenvironment is a complex and heterogeneous milieu in which multiple interactions occur between tumor and host cells. Immunosuppressive cells which are present in this microenvironment, such as regulatory T (Treg) cells and myeloid-derived suppressor cells (MDSCs), play an important role in tumor progression, via down-regulation of antitumor responses. MDSCs represent a heterogeneous group of cells originated from the myeloid lineage that are in the immature state. These cells markedly accumulate... περισσότερα »
Anti-tumor angiogenesis effect of a new compound: B-9-3 through interference with VEGFR2 signaling
Anti-tumor angiogenesis effect of a new compound: B-9-3 through interference with VEGFR2 signaling: AbstractB-9-3, a derivative of harmine, was first synthesized in our laboratory. We have reported that B-9-3 has an anti-proliferative effect against human lung cancer cells via induction of apoptosis and inhibition of cell migration. In the present study, we first studied that the anti-tumor angiogenesis effect and the molecular mechanism of B-9-3-induced tumor vascular degrade and mortify in lung cancer. In vitro, the results showed that B-9-3 selectively inhibited the proliferatio... περισσότερα »
Expression of chemokine receptor CXCR4 is closely correlated with clinical outcome in human nasopharyngeal carcinoma
Expression of chemokine receptor CXCR4 is closely correlated with clinical outcome in human nasopharyngeal carcinoma: AbstractThe CXC chemokine receptor 4 (CXCR4) has been reported to be involved in the development and progression of nasopharyngeal carcinoma (NPC). However, the role of CXCR4 in clinical outcome and prognosis of NPC patients remains controversial. In the present study, we investigated and reviewed the expression of CXCR4 in NPC tissues and then analyzed the definitive role of CXCR4 in clinical outcome and prognosis. Here, we found that the expression level of CXCR4 ... περισσότερα »
Downregulation of long noncoding RNA NONHSAT037832 in papillary thyroid carcinoma and its clinical significance
Downregulation of long noncoding RNA NONHSAT037832 in papillary thyroid carcinoma and its clinical significance: AbstractLong noncoding RNA (lncRNA) is a kind of RNA that is longer than 200 nucleotides with limited or no protein-coding potential. Studies have proved that lncRNAs play important regulatory roles in gene expression and contribute to oncogenesis and cancer metastasis. However, the expression level of lncRNAs and their clinicopathologic significance in papillary thyroid carcinoma (PTC) have not been well studied. In this study, we investigated the expression level of a ...περισσότερα »
Dendritic cells modulate burn wound healing by enhancing early proliferation
Dendritic cells modulate burn wound healing by enhancing early proliferation: [image: cover.gif?v=1&s=4e06cdb9cbac42b01d5dfc71] Abstract Adequate wound healing is vital for burn patients in order to reduce the risk of infections and prolonged hospitalization. Dendritic cells (DCs) are antigen presenting cells that release cytokines and are central for the activation of innate and acquired immune responses. Studies have demonstrated their presence in human burn wounds; however their role in burn wound healing remains to be determined. This study investigated the role of DCs in m... περισσότερα »
Kinasen als Ziele molekularer Tumortherapie
Kinasen als Ziele molekularer Tumortherapie: Zusammenfassung HintergrundIn den letzten Jahren wurden durch molekulare Tumortherapeutika wesentliche Fortschritte in der Behandlung maligner Erkrankungen erzielt. Hintergrund ist ein spezifischerer Angriff auf maligne Zellen unter Vermeidung von Begleittoxizität konventioneller antineoplastischer Therapie. Ein wichtiger Angriffspunkt heutiger molekularer Tumortherapie sind Kinasen, die durch kleine Kinaseinhibitoren oder – im Falle von Rezeptorkinasen – auch durch monoklonale Antikörper gehemmt werden können. Material und MethodenD...περισσότερα »
Molekulare Diagnostik der blasenbildenden Autoimmundermatosen
Molekulare Diagnostik der blasenbildenden Autoimmundermatosen: ZusammenfassungBlasenbildende Autoimmundermatosen sind organspezifische Erkrankungen, in denen es zu einer autoantikörpervermittelten Spaltbildung an Haut und/oder Schleimhäuten kommt. Der Nachweis gewebsgebundener und im Serum zirkulierender Autoantikörper ist notwendig für die Diagnose. Die Unterformen dieser Erkrankungsgruppe sind klinisch häufig schwer zu differenzieren. Eine präzise Diagnose ist jedoch wichtig, da sie Prognose und Therapieregime maßgeblich beeinflusst. Als etablierte diagnostische Verfahren haben s... περισσότερα »
Infective endocarditis caused by different groups of non-beta haemolytic streptococci
Clinical presentation of infective endocarditis caused by different groups of non-beta haemolytic streptococci: AbstractStreptococci are common causes of infective endocarditis (IE) and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has provided a practical tool for their species determination. We aimed to investigate if particular groups of non-beta heamolytic streptococci were associated with IE or to specific presentations thereof. The Swedish Registry of Infective Endocarditis was used to identify cases of IE caused by streptococci a...περισσότερα »
Prognostic indices in stereotactic radiotherapy of brain metastases
Prognostic indices in stereotactic radiotherapy of brain metastases of non-small cell lung cancer: Abstract BackgroundOur purpose was to analyze the long-term clinical outcome and to identify prognostic factors after Linac-based stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT) on patients with brain metastases (BM) from non-small cell lung cancer (NSCLC). Materials and MethodsWe performed a retrospective analysis of survival on 90 patients who underwent SRS or FSRT of intracranial NSCLC metastases between 04/2004 and 05/2014 that had not undergon...περισσότερα »
Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy
Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy: Abstract BackgroundWhole brain radiation therapy (WBRT) is widely used for the treatment of brain metastases. Cognitive decline and alopecia are recognized adverse effects of WBRT. Recently hippocampus sparing whole brain radiation therapy (HS-WBRT) has been shown to reduce the incidence of memory loss. In this study, we found that multi-field intensity modulated radiation therapy (IMRT), with strict constraints to the brain parenchyma and to the hippocampus, reduces follicu...περισσότερα »
Activation of NLRP3 inflammasome in human neutrophils by Helicobacter pylori infection
Activation of NLRP3 inflammasome in human neutrophils by Helicobacter pylori infection: TLRs and NLRs participate in the immune system recognition of *Helicobacter pylori*. However, little is known about the mechanisms leading to inflammasome activation by *H. pylori* and if NLRs in neutrophils are involved in the process. We studied how NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome components are involved in IL-1β maturation in human neutrophils in response to the infection and if they are dependent on T4SS (type IV secretion system) and TLRs. Human neu... περισσότερα »
Risk Factor Analysis of Bone Resorption Following Secondary Alveolar Bone Grafting Using Three-Dimensional Computed Tomography
Risk Factor Analysis of Bone Resorption Following Secondary Alveolar Bone Grafting Using Three-Dimensional Computed Tomography: The purpose of this study is to analyze the risk factors for bone resorption following secondary bone grafting in the alveolar cleft, using three-dimensional computed tomography based on surgical simulation software (SimPlant OMS,Materialise, Leuven, Belgium).
Assessing Safety of Negative Pressure Wound Therapy over Pedicled Muscle Flaps: A Retrospective Review of Gastrocnemius Muscle Flap
Assessing Safety of Negative Pressure Wound Therapy over Pedicled Muscle Flaps: A Retrospective Review of Gastrocnemius Muscle Flap: The use of negative pressure wound therapy for management of open wounds and immobilization of split-thickness skin grafts over wounds has been well described. However, there is a concern for potential compromise of flap viability when negative pressure wound therapy is used for skin grafts over pedicled muscle flaps. We have used negative pressure wound therapy to immobilize split-thickness skin grafts in eight patients who underwent a pedicled gastro... περισσότερα »
Rating of daytime and night-time symptoms in RLS: validation of the RLS-6 scale of restless legs syndrome / willis-ekbom disease
Rating of daytime and night-time symptoms in RLS: validation of the RLS-6 scale of restless legs syndrome / willis-ekbom disease: • The IRLS is the main scale for rating the severity of Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED).• The RLS-6 is an additional scale for rating the severity of RLS that provides additional information on RLS severity not captured by the IRLS.• In the current validation study the RLS-6 seems to be an acceptable, reliable, precise, valid, and responsive instrument for the assessment of RLS severity in a specific and pragmatic way.• At the curren...περισσότερα »
Oxymetazoline Applied Topically to the Nasal Mucosa Decreases Trans-Mucosal Nitrous Oxide Exchange for the Middle Ear
Oxymetazoline Applied Topically to the Nasal Mucosa Decreases Trans-Mucosal Nitrous Oxide Exchange for the Middle Ear: Objective: Determine if the middle ear (ME) trans-mucosal nitrous oxide (N2O) gas exchange rate can be pharmacologically modulated by the nasal application of a vasoconstrictor. Methods: In a randomized, double-blind, crossover study, 20 adults received a nasal spray challenge containing either oxymetazoline or saline (placebo). At each session, subjects were fitted with a non-rebreathing mask and breathed room air for 20 minutes, 50% N2O:50% O2 for 20 minutes, and... περισσότερα »
The Impact of Treatment on Antral Mucociliary Clearance: Uncinectomy Versus Balloon Sinuplasty
A Controlled, Randomized Clinical Study on the Impact of Treatment on Antral Mucociliary Clearance: Uncinectomy Versus Balloon Sinuplasty: Objectives: To find out the effect of minimal invasive sinus surgery and balloon sinuplasty on mucociliary clearance and compare different methods of measuring mucociliary clearance. Methods: Twenty-nine patients with chronic rhinosinusitis were randomized in 2 operative groups (uncinectomy or balloon sinuplasty). Before and 6 months after the treatment, patients filled out a quality of life questionnaire (Sino Nasal Outcome Test-22 [SNOT-22]),... περισσότερα »
High-Grade Neuroendocrine Carcinoma of the Larynx: The Mayo Clinic Experience
High-Grade Neuroendocrine Carcinoma of the Larynx: The Mayo Clinic Experience: Objective: To report a single institutional series of high-grade neuroendocrine carcinoma of the larynx (NCL), a very rare yet aggressive tumor. To review the management of NCL, including discussion of clinical behavior, treatment outcome, and prognosis. Method: A retrospective chart review of high-grade laryngeal neuroendocrine carcinomas at a single institution, including small- and large-cell neuroendocrine carcinomas. A total of 8 patients with high-grade NCL treated at our institution from 1992 to ... περισσότερα »
Glottic Cancer: A Metamorphosing Disease
Glottic Cancer: A Metamorphosing Disease: Objective: Conventional wisdom is that the overwhelming majority of glottic cancer patients have a smoking history. However, in recent years observations suggested that an increasing number of glottic cancer patients had never been smokers. Therefore, an investigation was done examining the incidence of having a smoking history in a recent cohort of glottic cancer patients. Method: Retrospective review of 100 patients with glottic cancer to determine those reporting never having smoked. Results: Thirty-one of 100 did not have a smoking his...περισσότερα »
Language mapping using high gamma electrocorticography, fMRI, and TMS versus electrocortical stimulation
Language mapping using high gamma electrocorticography, fMRI, and TMS versus electrocortical stimulation: One of the goals in neurosurgery is to resect pathological brain tissue, while minimizing postsurgical functional impairments. In view of inter-individual variability in functional anatomy, especially for language (Ojemann 2003), it becomes necessary to perform presurgical functional mapping and assess the risk of neurological impairments following surgery on an individual basis. Cortical stimulation mapping (CSM) is the conventional clinical standard-of-care for functional mapp... περισσότερα »
Endoscopic biopsy and EUS for the detection of pathologic complete response after neoadjuvant chemoradiotherapy in esophageal cancer: a systematic review and meta-analysis
Endoscopic biopsy and EUS for the detection of pathologic complete response after neoadjuvant chemoradiotherapy in esophageal cancer: a systematic review and meta-analysis: Accurate determination of residual cancer status after neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer could assist in selecting the optimal treatment strategy. The aim of this study was to review the evidence on the diagnostic accuracy of endoscopic biopsy and EUS after nCRT for detecting residual cancer at the primary tumor site (ypT+) and regional lymph nodes (ypN+) as opposed to a pathologic complet... περισσότερα »
Effet de l’extrait éthanolique des écorces du tronc de Buchholzia coriacea sur quelques paramètres asthmatiques chez le rat
Résumé *Buchholzia coriacea* (Capparidacea), est une espèce utilisée en médecine traditionnelle dans le bassin de Congo pour le soulagement des affections courantes dont les maladies inflammatoires, l'asthme, les douleurs, la fièvre, les plaies, les abcès. Le présent travail a pour l'objectif d'étudier l'écorce de *Buchholzia coriacea* sur quelques paramètres asthmatiques chez les rats wistar. L'extrait éthanolique de *Buchholzia coriacea* est administré aux rats sensibilisés à ovalbumine. La migration leucocytaire et l'infiltration du liquide plasmatique dans les voies respiratoi... περισσότερα »
Note de Lecture
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Tussilage: Tussilago farfara L. (Asteraceae)
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Revue commentée de plantes médicinales
Abstract La plante nommée ǁhoba ([kǁʰɔbɑ] par les Bushmans était déjà connue pour un effet au niveau de l'hypothalamus [1]. Une équipe brésilienne de neuropharmacologie de Fortaleza a cherché à savoir quel autre effet pourrait avoir l'extrait de *Hoodia gordonii* (Masson) Sweet ex Decne. Des souris ont été traitées par des administrations pendant 15 jours de 25 et 50 mg/kg-poids d'extrait de *H. gordonii* et ont été soumises au test de la nage forcée et à l'open-field test. Une administration unique de cet extrait a fait baisser l'immobilité de l'animal dans le test de nage forcée... περισσότερα »
« In manu imperiti est sicut gladius strictus in dextra furiosi »
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Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT)
SUNCT syndrome: A cohort of 15 Portuguese patients: Background In this paper, we describe a cohort of patients with short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT), a rare trigeminal autonomic headache, managed in the outpatient clinic of a tertiary hospital. Methods Patients were identified through review of individual records between January 1, 2008 and June 30, 2014. Results Fifteen patients were identified (eight males:seven females), with mean age at onset of 49.7 years, mean number of attacks per day of 7.5 and mean att... περισσότερα »
Late onset aura may herald cerebral amyloid angiopathy
Late onset aura may herald cerebral amyloid angiopathy: A case report: Background Although migraine usually begins in the early decades of life, late onset of migraine with aura is occasionally observed and can occur without headache, causing confusion in the differential diagnosis. Case report A 72-year-old man presented with recurrent episodes of visual aura lasting for 20 minutes. These episodes had started at 57 years of age and were only once accompanied by a severe headache. Magnetic resonance imaging revealed changes in the periventricular white matter, left occipital haemor...περισσότερα »
CD19IL-10 regulatory B cells affect survival of tongue squamous cell carcinoma patients and induce resting CD4 T cells to CD4Foxp3 regulatory T cells
CD19IL-10 regulatory B cells affect survival of tongue squamous cell carcinoma patients and induce resting CD4 T cells to CD4Foxp3 regulatory T cells: Cancer escape is an active process that regulates immune responses by employing immunosuppressive cells. Regulatory T cells (Tregs) as a major immunosuppressive cell mediate antitumor effector cells through inhibitory receptor cell contact (PD1/PDL1 interaction) or secreted factors such as IL-10, TGF-β, IL-27, and IL-35 [1,2]. Evidence linking Tregs in tumor-promoting was offered by the increased levels of Tregs in peripheral blood an...περισσότερα »
Cost–utility of sentinel lymph node biopsy in cT1–T2N0 oral cancer
Cost–utility of sentinel lymph node biopsy in cT1–T2N0 oral cancer: The management of the clinically N0 (cN0) neck in T1–T2 oral cancer patients is controversial. Either elective neck dissection (END) or watchful waiting (WW) is performed, depending on the perceived chance of occult lymph node metastases. Nowadays, more and more evidence supports the use of diagnostic tools to stage the clinically negative neck more reliable, in addition to palpation and/or imaging techniques (ultrasound, CT, MRI and/or PET). When uncertainty about the existence of occult lymph node metastases decrea...περισσότερα »
Superficial oral mucoceles in cancer patient after radiation therapy
Superficial oral mucoceles in cancer patient after radiation therapy: An overlooked yet imperative phenomenon: Several complications may appear in the cancer patients affecting the oral mucosae and salivary glands, either treated by radiation, cytotoxic chemotherapeutics, targeted therapies, or hematopoietic stem cell transplantation. Most of research studied these patients focused in oral mucositis and hyposalivation [1]. Other complications include necrosis of mucosae and jawbones, oral and peri-oral fibrosis, oral infections, dental caries, neuropathy and taste disturbances. Howe... περισσότερα »
Evaluation of 99m Tc-TRODAT-1 SPECT in the diagnosis of Parkinson’s disease versus other progressive movement disorders
Abstract Objective Parkinson disease (PD), parkinsonian syndromes (PS) and essential tremor (ET) are different types of movement disorders which share some symptoms resulting in a difficulty of certain diagnosis. This study was conducted to determine the value of 99mTc-TRODAT-1 scan to differentiate PD from ET and other PS cases. Methods Totally, 75 patients were studied including 29 PD, 6 possible PD, 22 ET and 18 PS cases. A dual-head SPECT-CT was used to perform basal ganglia (BG) imaging following administration of 99mTc-TRODAT-1. The BG uptake values were normalized to whole...περισσότερα »
The UK National Flap Registry (UKNFR): A National Database for all pedicled and free flaps in the UK
The UK National Flap Registry (UKNFR) is a cross-speciality National Clinical Audit with participation by the British Association of Plastic Reconstructive and Aesthetic Surgeons (BAPRAS), British Association of Head and Neck Oncologists (BAHNO), British Association of Oral and Maxillofacial Surgeons (BAOMS) and Association of Breast Surgery (ABS). The aim of UKNFR is to collect information about all major pedicled and free flap operations carried out in the UK and through that, assess the quality of care we provide for patients. from #Aesthetics via alexandrossfakianakis on Inore...περισσότερα »
R.I.P. the “Re:” Letter to the Editor
The "Re:" letter to the editor typically begins in one of several familiar ways: from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1QKqwJy via IFTTT
List of Reviewers 2015
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Effects of birth weight and growth on childhood wheezing disorders
Effects of birth weight and growth on childhood wheezing disorders: findings from the Born in Bradford Cohort: Objectives To examine the effects of birth weight and childhood growth on childhood wheezing disorders. We hypothesised that low birth weight and fast growth during early age would increase the risk of wheezing disorders. Setting Observational secondary analysis of data from the Born in Bradford cohort. Participants All children who were born at the Bradford Royal Infirmary hospital between March 2007 and December 2010 were eligible for the study. A total of 13 734 and 15... περισσότερα »
Cervical transforaminal epidural steroid injections are commonly performed for temporary pain relief or diagnostic presurgical planning in patients with cervical radiculopathy
CT-Fluoroscopic Cervical Transforaminal Epidural Steroid Injections: Extraforaminal Needle Tip Position Decreases Risk of Intravascular Injection [INTERVENTIONAL]: BACKGROUND AND PURPOSE: Cervical transforaminal epidural steroid injections are commonly performed for temporary pain relief or diagnostic presurgical planning in patients with cervical radiculopathy. Intravascular injection of steroids during the procedure can potentially result in cord infarct, stroke, and even death. CT-fluoroscopy allows excellent anatomic resolution and precise needle positioning. This study sought t...περισσότερα »
The Solitaire arm of the Solitaire FR With the Intention For Thrombectomy (SWIFT)
TICI and Age: What's the Score? [INTERVENTIONAL]: BACKGROUND AND PURPOSE: Previous studies have suggested that advanced age predicts worse outcome following mechanical thrombectomy. We assessed outcomes from 2 recent large prospective studies to determine the association among TICI, age, and outcome. MATERIALS AND METHODS: Data from the Solitaire FR Thrombectomy for Acute Revascularization (STAR) trial, an international multicenter prospective single-arm thrombectomy study and the Solitaire arm of the Solitaire FR With the Intention For Thrombectomy (SWIFT) trial were pooled. TICI ... περισσότερα »
T1-Weighted Postcontrast Brain Imaging: A Spiral Spin-Echo MR Imaging Technique for Improved Flow Artifact Suppression
A Spiral Spin-Echo MR Imaging Technique for Improved Flow Artifact Suppression in T1-Weighted Postcontrast Brain Imaging: A Comparison with Cartesian Turbo Spin-Echo [ADULT BRAIN]: BACKGROUND AND PURPOSE: A challenge with the T1-weighted postcontrast Cartesian spin-echo and turbo spin-echo brain MR imaging is the presence of flow artifacts. Our aim was to develop a rapid 2D spiral spin-echo sequence for T1-weighted MR imaging with minimal flow artifacts and to compare it with a conventional Cartesian 2D turbo spin-echo sequence. MATERIALS AND METHODS: T1-weighted brain imaging was ... περισσότερα »
Risk Factors for Growth of Intracranial Aneurysms
Risk Factors for Growth of Intracranial Aneurysms: A Systematic Review and Meta-Analysis [INTERVENTIONAL]: BACKGROUND AND PURPOSE: Understanding risk factors for intracranial aneurysm growth is important for patient management. We performed a meta-analysis examining risk factors for intracranial aneurysm growth in longitudinal studies and examined the association between aneurysm growth and rupture. MATERIALS AND METHODS: We searched the literature for longitudinal studies of patients with unruptured aneurysms. We examined the associations of demographics, multiple aneurysms, prior... περισσότερα »
A software tool for pure‑tone audiometry
A software tool for pure‑tone audiometry: Abstract ObjectiveSelecting subjects for clinical trials on hearing loss therapies relies on the patient meeting the audiological inclusion criteria. In studies on the treatment of idiopathic sudden sensorineural hearing loss, the patient’s acute audiogram is usually compared with a previous audiogram, the audiogram of the non-affected ear, or a normal audiogram according to an ISO standard. Generally, many more patients are screened than actually fulfill the particular inclusion criteria. The inclusion criteria often require a calculation... περισσότερα »
The Cervical Orthosis on Swallowing Physiology and Cervical Spine Motion During Swallowing
The Effect of the Cervical Orthosis on Swallowing Physiology and Cervical Spine Motion During Swallowing: AbstractCervical orthosis is used to immobilize the neck in various disorders such as trauma and post-operation. However, it is still uncertain how cervical orthosis restricts the degree of movement of the cervical spine during swallowing and how they affect swallowing physiology. The purpose of this study was to evaluate these issues using the Philadelphia® Collar. We conducted videofluorography of swallowing in 39 healthy subjects (23 men, 16 women; mean age of 34.3 years) wi...περισσότερα »
Modified Starch and Xanthan Gum Thickeners in Post-Stroke Oropharyngeal Dysphagia
A Comparative Study Between Modified Starch and Xanthan Gum Thickeners in Post-Stroke Oropharyngeal Dysphagia: AbstractThickeners are used in post-stroke oropharyngeal dysphagia (OD) as a compensatory therapeutic strategy against aspirations. To compare the therapeutic effects of modified starch (MS) and xanthan gum (XG) thickeners on swallow safety and efficacy in chronic post-stroke OD patients using clinical and videofluoroscopic (VFS) assessment. Patients were studied by clinical assessment (volume-viscosity swallow test, V-VST) and VFS using 3 volumes (5, 10, 20 mL) and 3 visc... περισσότερα »
Non-Instrumental Swallowing and Feeding Assessments in Pediatrics
Systematic Review: Non-Instrumental Swallowing and Feeding Assessments in Pediatrics: AbstractThere is a high incidence of parental reporting of abnormal swallowing and feeding function and the negative impacts thereof on children. As such there is a need for well validated assessments in the area of pediatric swallowing and feeding. While instrumental assessments are well validated, there is limited information available to guide the selection and use of non-instrumental assessments for swallowing and feeding function. The aim of this study was to identify and report on non-instr...περισσότερα »
Alopecia, hypogonadism, hearing impairment, diabetes mellitus, learning disabilities and extrapydamidal manifestations
Exome sequencing revealed a novel biallelic deletion in the DCAF17 gene underlying Woodhouse Sakati syndrome (WSS): Abstract Woodhouse Sakati Syndrome (WSS, MIM 241080) is a rare autosomal recessive genetic condition characterized by alopecia, hypogonadism, hearing impairment, diabetes mellitus, learning disabilities and extrapydamidal manifestations. Sequence variants in the gene *DCAF17*, encoding nucleolar substrate receptor, were identified as the underlying cause of inherited WSS. Considerable phenotypic heterogeneity exists in WSS with regard to severity, organs involvement a...περισσότερα »
Ocular tuberculosis
Shakarchi FI from #Medicine via ola Kala on Inoreader http://ift.tt/1NfjY3d via IFTTT
Accessory head of sternocleidomastoid – a case report
2015-11-26T16-54-08Z *Source:* National Journal of Clinical Anatomy Saranyha Deb Barma, Gunamani Rabba, Kunjalal Talukdar. from #Medicine via ola Kala on Inoreader http://ift.tt/1NbdZbw via IFTTT
A cadaveric study on the buccal branch of facial nerve – origin and its relation pattern to the parotid duct
2015-11-26T16-54-08Z *Source:* National Journal of Clinical Anatomy Sapna A K, Jayasree K. from #Medicine via ola Kala on Inoreader http://ift.tt/1NbdZbs via IFTTT
Accessory head of flexor digiti minimi: a case study
2015-11-26T16-54-08Z *Source:* National Journal of Clinical Anatomy Saibala Vanguri, Bethi Manasa. from #Medicine via ola Kala on Inoreader http://ift.tt/21iUx7c via IFTTT
The cadaveric oath – an important bioethical perspective in anatomy
2015-11-26T16-54-08Z *Source:* National Journal of Clinical Anatomy S P Sawant, Shaguphta Tasnim Shaikh, Avinash De Sousa. from #Medicine via ola Kala on Inoreader http://ift.tt/1NfjWZ8 via IFTTT
Gantzer muscles; a study on 50 cadaveric upper limbs
2015-11-26T16-54-08Z *Source:* National Journal of Clinical Anatomy Roshni Bajpe, Tarakeshwari R, Shubha R. from #Medicine via ola Kala on Inoreader http://ift.tt/1NbdYUT via IFTTT
A study on occurence of third throchanter in the femora in northern Tamil Nadu region
2015-11-26T16-54-08Z *Source:* National Journal of Clinical Anatomy N Muthukumaravel, K Y Manjunath. from #Medicine via ola Kala on Inoreader http://ift.tt/1NfjXwk via IFTTT
Incidence of furcate umbilical cord
2015-11-26T16-54-08Z *Source:* National Journal of Clinical Anatomy Khan Mohd Anas, Sinha D N, Singh AK, Deopa Deepa, Niranjan Richa. from #Medicine via ola Kala on Inoreader http://ift.tt/1QKcCHu via IFTTT
Combined variations of prhrenic, suprarenal gland and gonadal artery
2015-11-26T16-54-08Z *Source:* National Journal of Clinical Anatomy J Karpagajothi, S Bharathi Rani, N S Sunitha. from #Medicine via ola Kala on Inoreader http://ift.tt/1TgZk3E via IFTTT
Accessory muscles of hand : An evidence towards evolution of hand
2015-11-26T16-54-08Z *Source:* National Journal of Clinical Anatomy Geetha G N, Swathi, Sunita Athavale. from #Medicine via ola Kala on Inoreader http://ift.tt/1T8Ovjx via IFTTT
Harlequin ichthyosis - a rare genetic disorder: a case reprot
2015-11-26T16-54-08Z *Source:* National Journal of Clinical Anatomy Arnab Ghosh, B C Dutta, Sudipta Pal. from #Medicine via ola Kala on Inoreader http://ift.tt/1lkuXxA via IFTTT
Retinitis pigmentosa, essential iris atrophy and glaucoma
Meirelles SH, Barreto AS, Buscacio ES, Shinzato E, Patrão LF, Silva MS from #Medicine via ola Kala on Inoreader http://ift.tt/1lN9FJA via IFTTT
Relationship between consecutive deterioration of MD value and VFD in OAG
Naito T, Yoshikawa K, Mizoue S, Nanno M, Kimura T, Suzumura H, Takeda R, Shiraga F from #Medicine via ola Kala on Inoreader http://ift.tt/1lN8z0t via IFTTT
A role for left inferior frontal and posterior superior temporal cortex in extracting a syntactic tree from a sentence
Publication date: Available online 26 November 2015 *Source:*Cortex Author(s): Chotiga Pattamadilok, Stanislas Dehaene, Christophe Pallier Upon reading the sentence "the kids who exhausted their parents slept", how do we decide that it is the kids who slept, and not the parents? The present behavioral and fMRI study explored the processes underlying the extraction of syntactically organized information from sentences. Participants were presented with sentences whose syntactic complexity was manipulated using either a center-embedded or an adjunct structure. The goal was to vary sepa...περισσότερα »
Bilateral Idiopathic Adrenal Hyperplasia: Genetics and Beyond
Horm Metab Res DOI: 10.1055/s-0035-1565198 Bilateral adrenal hyperplasia currently accounts for up to 2 thirds of cases of primary aldosteronism. As such, it represents a major opportunity for targeted medical management as opposed to unilateral surgically correctable forms of the disease. Although the majority of cases of primary aldosteronism are sporadic, bilateral adrenal hyperplasia may occur in the context of familial hyperaldosteronism where it is associated with specific germline mutations. Over the past 5 years, impressive progress has been made in our understanding of th... περισσότερα »
‘Tipping the Balance’: Karl Friedrich Meyer, Latent Infections, and the Birth of Modern Ideas of Disease Ecology
Abstract The Swiss-born medical researcher Karl Friedrich Meyer (1884–1974) is best known as a 'microbe hunter' who pioneered investigations into diseases at the intersection of animal and human health in California in the 1920s and 1930s. In particular, historians have singled out Meyer's 1931 Ludwig Hektoen Lecture in which he described the animal kingdom as a 'reservoir of disease' as a forerunner of 'one medicine' approaches to emerging zoonoses. In so doing, however, historians risk overlooking Meyer's other intellectual contributions. Developed in a series of papers from the ... περισσότερα »
Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
[image: 53405fig1.jpg] The goal of this protocol is to use laser-capture micro-dissection as an effective method to isolate pure populations of cell types from heterogeneous prostate tissues for downstream RNA analysis. from #Medicine via ola Kala on Inoreader http://ift.tt/1XjjAr7 via IFTTT
A community-wide school health project for the promotion of smoke-free homes
Background: A community-wide school health project for the promotion of smoke-free homes was launched in June 2010 with the aim of promoting the benefits of smoke-free homes to all school-aged children (aged 6–18), and indirectly to their parents and family members. The 1-year project included health talks on a smoke-free life; the distribution of educational leaflets; slogan and visual art competitions; and a health fair held in June 2011. Two sets of questionnaires were developed to solicit a resolution and action from the participants regarding the establishment of a smoke-free... περισσότερα »
Parathyroid adenoma causing spontaneous cervical hematoma: two case reports
Background: Although spontaneous rupture of a cervical parathyroid adenoma with extracapsular hemorrhage is rare, it may cause cervical and mediastinal hematoma, leading to potentially fatal consequences.Case presentationThe first case was a 76-year-old Asian female who presented with pharyngeal discomfort and anterior chest ecchymosis. Endoscopic investigation showed submucosal hemorrhage in the pharynx and larynx. The second case was a 62-year-old Asian male who presented with anterior chest ecchymosis and suspected of a ruptured blood vessel. Both cases were diagnosed parathyro... περισσότερα »
Measurement of abdominal circumference in preterm infants
Background: Body weight, length and head and thoracic circumference are routinely measured in obstetric and neonatal departments. Reference values for these measurements have been established for the neonatal population. Neonatal abdominal circumference is not routinely measured, and no reference values for this measurement have been determined. To evaluate the increase in abdominal circumference in newborns with abdominal pathology such as necrotizing enterocolitis, information about normal abdominal circumference in healthy neonates shortly after birth is needed. The aim of this...περισσότερα »
Risk Factors for Growth of Intracranial Aneurysms: A Systematic Review and Meta-Analysis [INTERVENTIONAL]
BACKGROUND AND PURPOSE: Understanding risk factors for intracranial aneurysm growth is important for patient management. We performed a meta-analysis examining risk factors for intracranial aneurysm growth in longitudinal studies and examined the association between aneurysm growth and rupture. MATERIALS AND METHODS: We searched the literature for longitudinal studies of patients with unruptured aneurysms. We examined the associations of demographics, multiple aneurysms, prior subarachnoid hemorrhage, family history of aneurysm or subarachnoid hemorrhage, smoking, and hypertensi... περισσότερα »
A Spiral Spin-Echo MR Imaging Technique for Improved Flow Artifact Suppression in T1-Weighted Postcontrast Brain Imaging: A Comparison with Cartesian Turbo Spin-Echo [ADULT BRAIN]
BACKGROUND AND PURPOSE: A challenge with the T1-weighted postcontrast Cartesian spin-echo and turbo spin-echo brain MR imaging is the presence of flow artifacts. Our aim was to develop a rapid 2D spiral spin-echo sequence for T1-weighted MR imaging with minimal flow artifacts and to compare it with a conventional Cartesian 2D turbo spin-echo sequence. MATERIALS AND METHODS: T1-weighted brain imaging was performed in 24 pediatric patients. After the administration of intravenous gadolinium contrast agent, a reference Cartesian TSE sequence with a scanning time of 2 minutes 30 sec... περισσότερα »
Pipeline Embolization Device in the Treatment of Recurrent Previously Stented Cerebral Aneurysms [ADULT BRAIN]
BACKGROUND AND PURPOSE: The use of the Pipeline Embolization Device in the management of recurrent previously stented cerebral aneurysms is controversial. The aim of this study was to evaluate the efficacy and safety of the Pipeline Embolization Device in the treatment of recurrent, previously stented aneurysms. MATERIALS AND METHODS: Twenty-one patients with previously stented recurrent aneurysms who later underwent Pipeline Embolization Device placement (group 1) were retrospectively identified and compared with 63 patients who had treatment with the Pipeline Embolization Devi...περισσότερα »
TICI and Age: What's the Score? [INTERVENTIONAL]
BACKGROUND AND PURPOSE: Previous studies have suggested that advanced age predicts worse outcome following mechanical thrombectomy. We assessed outcomes from 2 recent large prospective studies to determine the association among TICI, age, and outcome. MATERIALS AND METHODS: Data from the Solitaire FR Thrombectomy for Acute Revascularization (STAR) trial, an international multicenter prospective single-arm thrombectomy study and the Solitaire arm of the Solitaire FR With the Intention For Thrombectomy (SWIFT) trial were pooled. TICI was determined by core laboratory review. Good... περισσότερα »
CT-Fluoroscopic Cervical Transforaminal Epidural Steroid Injections: Extraforaminal Needle Tip Position Decreases Risk of Intravascular Injection [INTERVENTIONAL]
BACKGROUND AND PURPOSE: Cervical transforaminal epidural steroid injections are commonly performed for temporary pain relief or diagnostic presurgical planning in patients with cervical radiculopathy. Intravascular injection of steroids during the procedure can potentially result in cord infarct, stroke, and even death. CT-fluoroscopy allows excellent anatomic resolution and precise needle positioning. This study sought to determine the safest needle tip position during CT-guided cervical transforaminal epidural steroid injection as determined by the incidence of intravascular in... περισσότερα »
Basal Ganglia Iron in Patients with Multiple Sclerosis Measured with 7T Quantitative Susceptibility Mapping Correlates with Inhibitory Control [ADULT BRAIN]
BACKGROUND AND PURPOSE: T2 hypointensity in the basal ganglia of patients with MS has been associated with clinical progression and cognitive decline. Our objectives were the following: 1) to compare signal in T2WI, R2 (ie, 1/T2), and R2* (ie, 1/T2*) relaxation rates and quantitative susceptibility mapping; and 2) to investigate the associations among MR imaging, clinical scores, and cognitive measures of inhibitory control linked to basal ganglia functioning. MATERIALS AND METHODS: Twenty-nine patients with MS underwent a battery of neuropsychological tests including the Flank...περισσότερα »
