Modulation of P2X3 and P2X2/3 receptors by monoclonal antibodies. Membrane Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Purinergic homomeric P2X3 and heteromeric P2X2/3 receptors are ligand-gated cation channels activated by ATP. Both receptors are predominantly expressed in nociceptive sensory neurons and an increase in extracellular ATP concentration under pathological conditions such as tissue damage or visceral distension induces channel opening, membrane depolarization and initiation of pain signaling. Hence these receptors are considered […]
{gamma}-aminobutyric acid type A (GABAA) receptor subunits play a direct structural role in synaptic contact formation via their N-terminal extracellular domains Cell Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
The establishment of cell-cell contacts between presynaptic GABAergic neurons and their postsynaptic targets initiates the process of GABAergic synapse formation. GABAA receptors (GABAARs), the main postsynaptic receptors for GABA, have been recently demonstrated to act as synaptogenic proteins that can single-handedly induce the formation and functional maturation of inhibitory synapses. To establish how the subunit […]
The Molecular Chaperone GRP78 Contributes to TLR3-mediated Innate Immune Response to Hepatitis C Virus in Hepatocytes Microbiology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Toll-like receptor-3 (TLR3) senses double-stranded RNA intermediates produced during hepatitis C virus (HCV) replication, leading to activation of interferon-regulatory factor-3 (IRF3) and NF-κB and subsequent antiviral and proinflammatory responses. Yet, how this TLR3-dependent pathway operates in hepatocytes is unclear. Upon fractionating cultured hepatocytes into various cellular organelles, we observed that TLR3 predominantly resides in endolysosomes […]
The Steroid Hormone 20-hydroxyecdysone Enhances Gene Transcription through the cAMP Response Element-binding Protein (CREB) Signaling Pathway Signal Transduction
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Animal steroid hormones regulate gene transcription through genomic pathways by binding to nuclear receptors. These steroid hormones also rapidly increase intracellular calcium and cyclic adenosine monophosphate (cAMP) levels and activate the protein kinase C (PKC) and protein kinase A (PKA) nongenomic pathways. However, the function and mechanism of the nongenomic pathways of the steroid hormones […]
RACK1 promotes Dishevelled degradation via autophagy and antagonizes Wnt signaling Cell Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Wnt signaling plays a critical role in embryonic development, tissue homeostasis and cancer development. Dishevelled (Dvl) is an essential and central component in Wnt signaling, and its stability and activity is tightly regulated. It has been shown that Dvl can be degraded via both the proteasome and autophagy-lysosome pathways. Here we report that RACK1 (receptor […]
Issue Information – Contents
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
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Lapatinib-Related Rash and Breast Cancer Outcome in the ALTTO Phase III Randomized Trial
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Background: Previously we have shown that early development of rash is associated with a higher chance of achieving pathological complete response to neoadjuvant lapatinib. In the current analysis, we investigate its impact on survival in the ALTTO phase III adjuvant trial. Methods: In ALTTO, patients with human epidermal growth factor receptor 2 (HER2)–positive early breast […]
First case of pancreas transplant alone in patient with diabetes and HIV infection
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Chronic conditions have largely replaced opportunistic infections as the leading causes of mortality in human immunodeficiency virus (HIV) infection. Pancreas transplantation alone can be performed for people with difficult to manage diabetes associated with severe hypoglycaemic unawareness. For carefully selected patients, pancreas transplantation alone has the potential to dramatically improve quality and quantity of life. […]
Peru’s HIV care continuum among men who have sex with men and transgender women: opportunities to optimize treatment and prevention
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
The HIV epidemic in Peru is concentrated in men who have sex with men and transgender women, who have an estimated prevalence > 10%, while the overall population prevalence remains < 1%. Because MSM and TW account for >60% of new infections, it is crucial to understand the full HIV continuum of care for these […]
Portrait of trauma care in Quebec’s rural emergency departments and identification of priority intervention needs to improve the quality of care: a study protocol
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Introduction Trauma remains the primary cause of death in individuals under 40 years of age in Canada. In Quebec, the Trauma Care Continuum (TCC) has been demonstrated to be effective in decreasing the mortality rate among trauma victims. Although rural citizens are at greater risk for trauma and trauma death, no empirical data concerning the […]
Aetiology and pathology of otitis media with effusion in adult life
Review ArticlesAetiology and pathology of otitis media with effusion in adult lifeR Millsa1 c1 and I Hathorna1 a1 Otolaryngology Unit, University of Edinburgh, Scotland, UK Abstract Objectives: To gather and analyse information concerning the aetiology and pathology of otitis media with effusion in adults. Method: A review of the English language literature from 1970 to the present was conducted. Results: The available evidence suggests that otitis media with effusion in adult life is best viewed as a syndrome with a number of causes, including: infiltration of the eustachian tube by n...περισσότερα »
Modified Todd's meatoplasty
Short CommunicationHow I do it: modified Todd's meatoplastyA N Elsamanodya1 a2 c1, V Topsakala1, W Grolmana1 and R A Tangea1 a1 Department of Otorhinolaryngology and Head and Neck Surgery, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands a2 Department of Otorhinolaryngology, Al-Hussein University Hospital, Al-Azhar University, Cairo, Egypt Abstract Background: Chronic otorrhoea after canal wall down mastoidectomy can be a clinical challenge. Basic principles for canal wall down surgery include establishing a large meatus. Several meatoplasty t...περισσότερα »
Thiol/disulphide homeostasis as a novel indicator of oxidative stress in sudden sensorineural hearing loss
Main ArticlesThiol/disulphide homeostasis as a novel indicator of oxidative stress in sudden sensorineural hearing lossM E Dinca1 c1, S Ulusoya1, A Isa2, N N Ayana3, M O Avincsala1, C Bicera4 and O Erela4 a1 Department of Otolaryngology, Head and Neck Surgery, Istanbul Gaziosmanpasa Taksim Research and Training Hospital, Istanbul, Turkey a2 Department of Otolaryngology, Head and Neck Surgery, Erciş State Hospital, Van, Turkey a3 Department of Medical Biochemistry, Istanbul Gaziosmanpasa Taksim Research and Training Hospital, Istanbul, Turkey a4 Department of Medical Biochemistry, Dışka... περισσότερα »
Occupational musculoskeletal pain amongst ENT surgeons – are we looking at the tip of an iceberg?
Main ArticlesOccupational musculoskeletal pain amongst ENT surgeons – are we looking at the tip of an iceberg?A Vijendrena1 c1, M Yunga1, J Sancheza2 and K Duffielda3 a1 Department of ENT, Ipswich Hospital, UK a2 Department of Occupational Health, Ipswich Hospital, UK a3 Department of Physiotherapy, Ipswich Hospital, UK Abstract Objective: Surgeons are exposed to a variety of occupational risks, including work-related musculoskeletal disorders. This study investigated the prevalence of these latter disorders amongst UK ENT surgeons and compared this with the existing literature. Method... περισσότερα »
Latest trends in the assessment and management of paediatric snoring and sleep apnoea
Main ArticlesLatest trends in the assessment and management of paediatric snoring and sleep apnoeaS D Sharmaa1 c1, H Kanonaa1, G Kumara1 and B Kotecha a1 a1 Department of Otorhinolaryngology, Queen's Hospital, Romford, UK Abstract Objective: To investigate the assessment and management of paediatric snoring and obstructive sleep apnoea in UK otolaryngology departments. Method: A telephone questionnaire survey of UK otolaryngology departments was conducted over a 16-week period. Results: The response rate was 61 per cent (85 out of 139 trusts). Use of pre-operative pulse oximetry was rep... περισσότερα »
Midfacial Soft-Tissue Changes after Paranasal Augmentation with Porous Polyethylene
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Facial plast Surg 2016; 32: 232-237 DOI: 10.1055/s-0036-1582230 The aim of this study was to determine the effect of porous polyethylene in paranasal augmentation on the overlying soft tissue. Thirty-three patients underwent paranasal augmentation using 3-mm-thick porous polyethylene and mandibular setback, and 35 patients underwent mandibular setback only. Lateral cephalograms were taken before and 6 […]
Global Cleft Surgery
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Facial plast Surg 2016; 32: 209-212 DOI: 10.1055/s-0036-1582247 Surgery has recently been properly recognized as an essential component of global health. Global cleft surgery, often performed by visiting surgical teams in many parts of the world, has evolved with the recent surge in interest in global surgery. This article explores that evolution. […] Thieme Medical […]
Management of Craniosynostosis
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Facial plast Surg 2016; 32: 123-132 DOI: 10.1055/s-0036-1582228 Many procedures exist for treatment of craniosynostosis. The goal of all surgical interventions is to correct the skull deformities associated with the synostosis and to prevent the sequela of elevated intracranial pressure. Open cranial vault reconstructions address these issues at the time of surgery, but have the […]
Occult level IV metastases in clinically node-negative patients with oral tongue squamous cell carcinoma
Main ArticlesOccult level IV metastases in clinically node-negative patients with oral tongue squamous cell carcinomaM Motiee-Langroudia1, A Amalia2, B Saedia1, H Emamia1, F Ensania2, A Lotfia3 and M Rabbani Anaria1 c1 a1 Otorhinolaryngology Research Center, Otolaryngology Department, Tehran University of Medical Sciences, Iran a2 Pathology Department, Tehran University of Medical Sciences, Iran a3 Otolaryngology Department, Tehran University of Medical Sciences, Iran Abstract Objective: The present study was conducted to determine the rate of level IV lymph node involvement among node... περισσότερα »
Prevention of gentamicin ototoxicity with N-acetylcysteine and vitamin A
Main ArticlesPrevention of gentamicin ototoxicity with N-acetylcysteine and vitamin AI Aladaga1, M Guvena2 and M Songua1 c1 a1 Department of Otorhinolaryngology, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey a2 Department of Otorhinolaryngology, Sakarya University Medical Faculty, Sakarya, Turkey Abstract Objective: To investigate the use of systemic N-acetylcysteine and vitamin A in the prevention of gentamicin ototoxicity in rats. Methods: Forty-two Wistar rats were divided into four groups according to treatment: intratympanic saline, intratymp...περισσότερα »
Glue ear in adults, paediatric sleep apnoea and the nose in exercise
Glue ear in adults, paediatric sleep apnoea and the nose in exercise:
Migrated Implant Causing Refractory Headache in Rhinoplasty
Migrated Implant Causing Refractory Headache in Rhinoplasty: Facial plast Surg 2016; 32: 241-241 DOI: 10.1055/s-0036-1580590
Autologous Costochondral Microtia Reconstruction
Autologous Costochondral Microtia Reconstruction: Facial plast Surg 2016; 32: 188-198 DOI: 10.1055/s-0036-1582229 Reconstruction with autologous costochondral cartilage is one of the mainstays of surgical management of congenital microtia. We review the literature, present our current technique for microtia reconstruction with autologous costochondral graft, and discuss the evolution of our technique over the past 20 years. We aim to minimize donor site morbidity and create the most durable and natural appearing ear possible using a stacked framework to augment the antihelical fold...περισσότερα »
The Use of Submental Island Flap for Total Lower Lip Reconstruction
A Case Report: Facial plast Surg 2016; 32: 238-239 DOI: 10.1055/s-0036-1571810 Total lower lip reconstruction was performed in a 72-year-old man following a squamous cell carcinoma resection. To obtain an optimal functional result and to avoid any additional facial scarring, a submental island flap was used in a one-stage procedure. After 2.5 years of follow-up, the patient is very satisfied with the shape and function of the lower lip.
Surgical Management of Pierre Robin Sequence
Using Mandibular Distraction Osteogenesis to Address Hypoventilation and Failure to Thrive in Infancy: Facial plast Surg 2016; 32: 177-187 DOI: 10.1055/s-0036-1581050 Mandibular hypoplasia may present in isolation or in the context of glossoptosis and a U-shaped, incomplete cleft palate. This latter triad is referred to as Pierre Robin sequence. Deleterious effects of micrognathia that may present during infancy are due primarily to glossoptosis or posterior displacement of the tongue. This tongue base prolapse may cause varying degrees of upper airway obstruction. A surgical opti... περισσότερα »
Beta-Glucan versus Provitamin Pantothenic Acid of Facial Burns
CO2 Laser Doppler and Digital Photo Analysis for Treatment Evaluation of Beta-Glucan versus Provitamin Pantothenic Acid of Facial Burns: Facial plast Surg 2016; 32: 225-231 DOI: 10.1055/s-0036-1579782 Various creams are available for superficial second-degree burns (SSDB) of the face. We evaluated provitamin pantothenic acid versus β-glucan for SSDB of the face using the O2C laser Doppler system and digital photo analysis. Out of 20 patients (January to December 2012) with facial burns, 7 with SSDB of both cheeks were included to our study. Burned cheek wounds were treated using pa...περισσότερα »
Evidence-Based Management of Vascular Malformations
Evidence-Based Management of Vascular Malformations: Facial plast Surg 2016; 32: 162-176 DOI: 10.1055/s-0036-1581141 Vascular malformations of the head and neck are complex lesions that are notoriously difficult to manage. Treatment of these lesions often requires a multispecialty and multimodal approach. In the modern era of evidence-based medicine, it has become imperative for clinicians to incorporate evidence-based treatment algorithms into their everyday practices. With general widespread inundation of the literature with levels IV and V clinical evidence, however, it is often... περισσότερα »
Technique in Cleft Rhinoplasty
The Foundation Graft: Facial plast Surg 2016; 32: 213-218 DOI: 10.1055/s-0036-1578567 Secondary cleft rhinoplasty represents a particular surgical challenge. The authors have identified the deficit in skeletal projection of the cleft-sided piriform rim as an important contributor to the pathology. A graft is described to augment the piriform crest on the cleft side. This foundation graft is suture fixated to the piriform crest after complete release of all soft tissue attachments to the alar base. The foundation graft is articulated with a long alar strut graft, which allows for p... περισσότερα »
Treating Velopharyngeal Dysfunction
State of the Art in Facial plast Surg 2016; 32: 156-161 DOI: 10.1055/s-0036-1581048 Velopharyngeal dysfunction (VPD) is a condition that can greatly impact a child's quality of life. The initial evaluation and workup of patients presenting with VPD is generally straightforward, consisting of history taking and physical examination, perceptual speech analysis, and objective techniques such as nasometry and speech endoscopy. However, there is no standardized treatment option. Multiple surgical and nonsurgical techniques have been described, all with varying approaches to correction... περισσότερα »
Gracilis Free Muscle Transfer in the Treatment of Pediatric Facial Paralysis
Gracilis Free Muscle Transfer in the Treatment of Pediatric Facial Paralysis: Facial plast Surg 2016; 32: 199-208 DOI: 10.1055/s-0036-1582248 Facial paralysis in children is a disabling functional and aesthetic issue. In cases where recovery is not expected, there are numerous options for reconstruction of the midface “smile.” At the Hospital for Sick Children in Toronto, Canada, we have been using a free functional gracilis muscle transfer. In this article, we review the technical details of the procedure, which we have refined over the past 30 years, and also briefly discuss sec... περισσότερα »
Cleft Lip Repair: The Hybrid Subunit Method
Cleft Lip Repair: The Hybrid Subunit Method: Facial plast Surg 2016; 32: 150-155 DOI: 10.1055/s-0036-1582227 The unilateral cleft lip repair is one of the most rewarding and challenging of plastic surgery procedures. Surgeons have introduced a variety of straight line, geometric, and rotation-advancement designs, while in practice the majority of North American surgeons have been using hybrids of the rotation-advancement techniques. The anatomic subunit approach was introduced in 2005 by Fisher and has gained popularity, with early adopters of the design touting its simplicity and ...περισσότερα »
Congenital Eyelid Deformity Management
State of the Art in Facial plast Surg 2016; 32: 142-149 DOI: 10.1055/s-0036-1581049 The eyelids are crucial in maintaining the health of the ocular surface and have an important role in facial aesthetics. Interruption in eyelid development can lead to congenital eyelid deformities. This article reviews eyelid anatomy, the most common congenital eyelid abnormalities such as congenital ptosis, eyelid coloboma, and epiblepharon, and the management of these conditions.
General self-consciousness (GSC) and Social self-consciousness of appearance (SSC)
Feeling Normal? Long-Term Follow-up of Patients with a Cleft Lip–Palate after Rhinoplasty with the Derriford Appearance Scale (DAS-59): Facial plast Surg 2016; 32: 219-224 DOI: 10.1055/s-0036-1579781 The stigma of nasal deformity due to a congenital cleft lip–palate has an undeniable influence on the affected patient's life. It is therefore of interest to investigate if efforts to reduce esthetic and functional impairments by rhinoplasty (single or multiple) can result in an increased satisfaction with appearance and a self-perception similar to the noncleft population. Retrospecti... περισσότερα »
The Derriford Appearance Scale (DAS-59)
Feeling Normal? Long-Term Follow-up of Patients with a Cleft Lip–Palate after Rhinoplasty with the Derriford Appearance Scale (DAS-59): Facial plast Surg 2016; 32: 219-224 DOI: 10.1055/s-0036-1579781 The stigma of nasal deformity due to a congenital cleft lip–palate has an undeniable influence on the affected patient's life. It is therefore of interest to investigate if efforts to reduce esthetic and functional impairments by rhinoplasty (single or multiple) can result in an increased satisfaction with appearance and a self-perception similar to the noncleft population. Retrospecti... περισσότερα »
Sexual and bodily self-consciousness of appearance (SBSC)
Feeling Normal? Long-Term Follow-up of Patients with a Cleft Lip–Palate after Rhinoplasty with the Derriford Appearance Scale (DAS-59): Facial plast Surg 2016; 32: 219-224 DOI: 10.1055/s-0036-1579781 The stigma of nasal deformity due to a congenital cleft lip–palate has an undeniable influence on the affected patient's life. It is therefore of interest to investigate if efforts to reduce esthetic and functional impairments by rhinoplasty (single or multiple) can result in an increased satisfaction with appearance and a self-perception similar to the noncleft population. Retrospecti... περισσότερα »
Patients with a Cleft Lip–Palate after Rhinoplasty
Feeling Normal? Long-Term Follow-up of Patients with a Cleft Lip–Palate after Rhinoplasty with the Derriford Appearance Scale (DAS-59): Facial plast Surg 2016; 32: 219-224 DOI: 10.1055/s-0036-1579781 The stigma of nasal deformity due to a congenital cleft lip–palate has an undeniable influence on the affected patient's life. It is therefore of interest to investigate if efforts to reduce esthetic and functional impairments by rhinoplasty (single or multiple) can result in an increased satisfaction with appearance and a self-perception similar to the noncleft population. Retrospecti... περισσότερα »
Facial Plastic Surgery
Congenital Deformities of the Face, Head, and Neck Management of Craniosynostosis Many procedures exist for treatment of craniosynostosis. The goal of all surgical interventions is to correct the skull deformities associated with the synostosis and to prevent the sequela of elevated intracranial pressure. Open cranial vault reconstructions address these issues at the time of surgery, but have the potential for increased blood loss and longer hospital stays. Minimally invasive procedures have shorter operative times and decreased blood loss, but rely on the cranial abnormality to imp... περισσότερα »
Variants of EVER1 and EVER2 ( TMC6 and TMC8 ) and human papillomavirus status in patients with mucosal squamous cell carcinoma of the head and neck
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Abstract Purpose There is a growing association of human papillomavirus (HPV) with some cases of mucosal squamous cell carcinoma of the head and neck (HNSCC), particularly of the oropharynx. Persistent oral HPV infection is believed to increase the likelihood of malignancy, and it is possible that host genetic factors can determine susceptibility to persistent HPV infection. Polymorphisms in the two EV genes (*EVER1* and *EVER2*, also known as *transmembrane channel protein (TMC) 6* and *8*) have been identified as strong candidate genes, since a small number of critical mutations ...περισσότερα »
Congenital Anomalies of the Nose
Congenital Anomalies of the Nose: Facial plast Surg 2016; 32: 133-141 DOI: 10.1055/s-0036-1582231 Congenital anomalies of the nose range from complete aplasia of the nose to duplications and nasal masses. Nasal development is the result of a complex embryologic patterning and fusion of multiple primordial structures. Loss of signaling proteins or failure of migration or proliferation can result in structural anomalies with significant cosmetic and functional consequences. Congenital anomalies of the nose can be categorized into four broad categories: (1) aplastic or hypoplastic, (2... περισσότερα »
Congenital Anomalies of the Nose
Congenital Anomalies of the Nose: Facial plast Surg 2016; 32: 133-141 DOI: 10.1055/s-0036-1582231 Congenital anomalies of the nose range from complete aplasia of the nose to duplications and nasal masses. Nasal development is the result of a complex embryologic patterning and fusion of multiple primordial structures. Loss of signaling proteins or failure of migration or proliferation can result in structural anomalies with significant cosmetic and functional consequences. Congenital anomalies of the nose can be categorized into four broad categories: (1) aplastic or hypoplastic, (2... περισσότερα »
Management of Craniosynostosis
Management of Craniosynostosis: Facial plast Surg 2016; 32: 123-132 DOI: 10.1055/s-0036-1582228 Many procedures exist for treatment of craniosynostosis. The goal of all surgical interventions is to correct the skull deformities associated with the synostosis and to prevent the sequela of elevated intracranial pressure. Open cranial vault reconstructions address these issues at the time of surgery, but have the potential for increased blood loss and longer hospital stays. Minimally invasive procedures have shorter operative times and decreased blood loss, but rely on the cranial abn... περισσότερα »
Midfacial Soft-Tissue Changes after Paranasal Augmentation with Porous Polyethylene
Midfacial Soft-Tissue Changes after Paranasal Augmentation with Porous Polyethylene: Facial plast Surg 2016; 32: 232-237 DOI: 10.1055/s-0036-1582230 The aim of this study was to determine the effect of porous polyethylene in paranasal augmentation on the overlying soft tissue. Thirty-three patients underwent paranasal augmentation using 3-mm-thick porous polyethylene and mandibular setback, and 35 patients underwent mandibular setback only. Lateral cephalograms were taken before and 6 months after the surgery to compare the soft-tissue changes in the paranasal area. Complications a...περισσότερα »
The role of Onodi cells in sphenoiditis
: results of multiplanar reconstruction of computed tomography scanning via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 20 April 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Mehmet Senturk, Ibrahim Guler, Isa Azgin, Engin Umut Sakarya, Gultekin Ovet, Necat Alatas, Ismet Tolu, Omer Erdur IntroductionOnodi cells are the most posterior ethmoid air cells and extend superolateral to the sphenoid sinus. These cells are also intimately related with the sphenoid sinus, optic nerve, and carotid artery. Radiologic eva... περισσότερα »
Caudal septal extension graft application in endonasal septoplasty
Effectiveness of via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 20 April 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Yunus Karadavut, Ilker Akyıldız, Hatice Karadaş, Aykut Erdem Dinç, Gökçe Tulacı, Eren Tastan IntroductionSeptal deviation is a common disease seen in daily otorhinolaryngology practice and septoplasty is a commonly performed surgical procedure. Caudal septum deviation is also a challenging pathology for ear, nose, and throat specialists. Many techniques are defined for caudal septal deviat...περισσότερα »
Surgical Anatomy of the Eyelids
Surgical Anatomy of the Eyelids: Slight alterations in the intricate anatomy of the upper and lower eyelid or their underlying structures can have pronounced consequences for ocular esthetics and function. The understanding of periorbital structures and their interrelationships continues to evolve and requires consideration when performing complex eyelid interventions. Maintaining a detailed appreciation of this region is critical to successful cosmetic or reconstructive surgery. This article presents a current review of the anatomy of the upper and lower eyelid with a focus on surg... περισσότερα »
Gastric emptying of solids in children: reference values for the 13C-octanoic acid breath test
Abstract Background 99mTechnetium scintigraphy (99mTS) is the 'gold standard' for measuring gastric emptying (GE), but it is associated with a radiation exposure. For this reason, the 13C-octanoic acid breath test (13C-OBT) was developed for measuring GE of solids. The objective of this study was to determine normal values for gastric half-emptying time (t1/2GE) of solids in healthy children. Methods Gastric emptying of a standardized solid test meal consisting of a pancake evaluated with 99mTS and 13C-OBT was compared in 22 children aged between 1 and 15 years with upper gastro... περισσότερα »
Endocannabinoid-related lipids are increased during an episode of cyclic vomiting syndrome
Abstract Background The endocannabinoid system and the hypothalamic–pituitary–adrenal axis are important neuromodulators of nausea and vomiting. This led us to hypothesize that patients with cyclic vomiting syndrome (CVS) have lower serum endocannabinoids (eCBs) and higher salivary cortisol and alpha amylase. Methods Serum eCBs and related lipids, *N*-oleoylethanolamine (OEA) and *N*-palmitoylethanolamide (PEA), and salivary cortisol, and alpha amylase (index of sympathetic nervous system activity) were measured in 22 CVS patients (age 40 ± 11, female = 17) in the well and sick ... περισσότερα »
Epithelial Cell Extrusion Zones Observed on Confocal Laser Endomicroscopy Correlates with Immunohistochemical Staining of Mucosal Biopsy Samples
Epithelial Cell Extrusion Zones Observed on Confocal Laser Endomicroscopy Correlates with Immunohistochemical Staining of Mucosal Biopsy Samples: Abstract Background and AimsThe density of epithelial cell extrusion zones in the intestinal lining, also known as gap density (number of gaps/1000 epithelial cells counted), can be quantitated using probe-based confocal laser endomicroscopy (pCLE). Gap density has been reported to be higher than normal in both inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) patients. Epithelial cells destined for extrusion from the i... περισσότερα »
Periorbital Surgery
Periorbital Surgery: Periorbital rejuvenation requires a careful understanding of the interplay between the eyelids, brow, forehead, and midface. Reversing periorbital signs of aging requires a correction of volume loss, soft tissue ptosis, and skin changes. Many surgical and nonsurgical techniques exist to treat the aging periorbital region; however, careful consideration of the patient’s complaints and existing anatomy is critical to achieving a safe and esthetically pleasing outcome. [image: First page of article]
Lower Eyelid Reconstruction
Lower Eyelid Reconstruction: Lower eyelid defects are common, and a systematic approach to reconstruction of the lower eyelid is required. Attention to the bilaminar eyelid anatomy and canthal support structures, with efforts to maintain functionally important structures, such as the lacrimal canalicular system, is vital to appropriate lower eyelid reconstruction. Techniques of advancement and rotation flaps and grafting of skin and mucosa are mainstays of lower eyelid reconstruction. An appropriate armamentarium of techniques allows for optimal surgical results. [image: First page ... περισσότερα »
Periorbital Surgery
Periorbital Surgery: Periorbital rejuvenation requires a careful understanding of the interplay between the eyelids, brow, forehead, and midface. Reversing periorbital signs of aging requires a correction of volume loss, soft tissue ptosis, and skin changes. Many surgical and nonsurgical techniques exist to treat the aging periorbital region; however, careful consideration of the patient’s complaints and existing anatomy is critical to achieving a safe and esthetically pleasing outcome. [image: First page of article]
Upper Lid Blepharoplasty
Upper Lid Blepharoplasty: Upper lid blepharoplasty is a common procedure for restoration and rejuvenation of the upper eyelids that can be performed safely and reliably. Understanding the anatomy and aging process of the brow–upper lid aesthetic unit along with properly assessing the excesses and deficiencies of the periorbital region helps to formulate an appropriate surgical plan. Volume deficiency in the aging upper lid may require corrective augmentation. Preexisting asymmetries and ptosis need to be identified and discussed before surgery. Standardized photography along with a ... περισσότερα »
Injectable Adjunctive Procedures for Cosmesis and Function
Injectable Adjunctive Procedures for Cosmesis and Function: The role of hyaluronic acid (HA) fillers in the periocular region continues to expand. In addition to cosmetic uses in the periocular region, HA fillers are increasingly being used to correct eyelid malpositions. This is changing the perspective on the anatomic changes responsible for these malpositions. [image: First page of article]
Periorbital Rejuvenation
Periorbital Rejuvenation: Numerous nonsurgical options for periorbital rejuvenation are available and can be used alone or as adjuncts to other nonsurgical and surgical options. Topicals, chemical peels, laser resurfacing, and dermabrasion therapy, along with neuromodulators and fillers, can be used to enhance the appearance of the periorbital region.
Upper Eyelid Reconstruction
Upper Eyelid Reconstruction: Reconstruction of the upper eyelid is complicated because the eyelid must retain mobility, flexibility, function, and a suitable mucosal surface over the delicate cornea. Defects of the upper eyelid may be due to congenital defects or traumatic injury or follow oncologic resection. This article focuses on reconstruction due to loss of tissue. Multiple surgeries may be needed to reach the desired results, addressing loss of tissue and then loss of function. Each defect is unique and the laxity and availability of surrounding tissue vary. Knowing the most ... περισσότερα »
Functional and Cosmetic Eyelid Surgery
Functional and Cosmetic Eyelid Surgery: I am excited to present this issue solely devoted to the upper and lower eyelids and surrounding periorbital tissues. Rather than addressing only cosmetic procedures, we wanted to address the periorbital region from both a reconstructive and an esthetic approach. It is my firm belief that each of these approaches to the periorbital region enhances the knowledge and skill of the periorbital surgeon.
Correction of Eyelid Crease Asymmetry and Ptosis
Correction of Eyelid Crease Asymmetry and Ptosis: Upper eyelid ptosis and crease abnormalities can lead to significant cosmetic deformity. An intimate knowledge of the anatomic structures responsible for eyelid height, contour, and pretarsal show will allow precise surgical correction. [image: First page of article]
Evaluation of Eyelid Function and Aesthetics
Evaluation of Eyelid Function and Aesthetics: The eyes and periocular area are the central aesthetic unit of the face. Facial aging is a dynamic process that involves skin, subcutaneous soft tissues, and bony structures. An understanding of what is perceived as youthful and beautiful is critical for success. Knowledge of the functional aspects of the eyelid and periocular area can identify pre-preoperative red flags. [image: First page of article]
Lower Lid Malposition
Lower Lid Malposition: Lower lid malposition is a common yet demanding problem that both functional and cosmetic eyelid surgeons will face. It encompasses a spectrum of lower eyelid conditions ranging from lower lid retraction to frank ectropion and entropion. The causes of lower lid malposition are numerous, and the problem can be challenging to correct even for experienced surgeons. Proper treatment of lower lid malpositioning requires a clear understanding of the lower eyelid anatomy, careful preoperative assessment, and appropriate selection of surgical and nonsurgical intervent... περισσότερα »
Complications in Eyelid Surgery
Complications in Eyelid Surgery: Eyelid surgery consists of challenging reconstructive and cosmetic procedures. Because of the complex anatomy and corresponding vital functions of the upper and lower eyelids, the avoidance of eyelid complications is of vital importance. Complications after eyelid surgery include basic complications (infection, granuloma) and vision-threatening complications. Preoperative history, physical examination, surgical planning, and meticulous surgical technique must be undertaken to prevent complications after eyelid surgery. In addition, patient knowledge,... περισσότερα »
The mechanism of smell loss in patients with type II congenital hyposmia
On via American Journal of Otolaryngology Publication date: Available online 20 April 2016 *Source:*American Journal of Otolaryngology Author(s): Robert I. Henkin, Mona Abdelmeguid, Alexandra B. Knöppel BackgroundSmell function has been initiated with theophylline treatment in 63% of patients with Type II congenital smell loss. Based upon a systematic evaluation of the protein components of nasal mucus we have demonstrated that interactions among four chemical moieties in nasal mucus may play significant roles in this initiation. Prior to treatment three of these moieties, cAMP, cGMP ...περισσότερα »
Lower Eyelid Blepharoplasty
Lower Eyelid Blepharoplasty: The goal of lower eyelid blepharoplasty is to rejuvenate the lower lid while maintaining a natural, unoperated appearance. Successful lower eyelid blepharoplasty depends on knowledge of the anatomy and surgical techniques, accurate preoperative analysis, and attention to detail. Common issues of the lower eyelid such as malar descent, tear trough deformity, pseudoherniated fat, lid laxity, and skin texture changes as well as dermatochalasis and festoons must be recognized. Specific techniques to address these include transcutaneous and transconjunctival ... περισσότερα »
Gene expression profiles and microRNA expression profiles identifies critical genes and microRNAs in oral lichen planus
A combinative analysis of via Oral Biology Publication date: August 2016 *Source:*Archives of Oral Biology, Volume 68 Author(s): Qing Liu, Xinwen Wang, Yuan Liu, Minghui Wei, Lihua Chen ObjectiveOral lichen planus (OLP) is a chronic inflammatory disease but aetiology and pathogenesis has not fully elucidated. To gain insight into the mechanism of OLP, bioinformatic analysis was performed in this study.DesignGSE38616 and GSE38615 were downloaded from GEO, including 7 cases of OLP and 7 healthy controls. Differentially expressed genes (DEGs) and miRNAs (DEMs) between OLP and control wer... περισσότερα »
Novel stress increases hypothalamic-pituitary-adrenal activity
in mice with a raised bite via Oral Biology Publication date: August 2016 *Source:*Archives of Oral Biology, Volume 68 Author(s): Hidekazu Miyake, Daisuke Mori, Tasuku Katayama, Shuu Fujiwara, Yuichi Sato, Kagaku Azuma, Kin-ya Kubo Background and objectiveIn humans, occlusal disharmony may cause various physical complaints, including head and neck ache, stiffness in the shoulder and neck, and arthrosis of the temporomandibular joints. Occlusal disharmony induced by raising the bite in rodents, increases plasma corticosterone levels, which leads to morphologic changes in the hippocamp...περισσότερα »
Predicting Periodontitis
at State and Local Levels in the United States: The objective of the study was to estimate the prevalence of periodontitis at state and local levels across the United States by using a novel, small area estimation (SAE) method. Extended multilevel regression and poststratification analyses were used to estimate the prevalence of periodontitis among adults aged 30 to 79 y at state, county, congressional district, and census tract levels by using periodontal data from the National Health and Nutrition Examination Survey (NHANES) 2009–2012, population counts from the 2010 US census, ... περισσότερα »
Psychological Interventions for Poor Oral Health
A Systematic Review: The aim of this systematic review and meta-analysis was to study the effectiveness of psychological interventions in adults and adolescents with poor oral health. The review follows the PRISMA guidelines for systematic reviews. The PICO format (population, intervention, comparison, and outcome) was used to define eligible studies. The populations were adults or adolescents (≥13 y of age and independent of others) with poor oral health (defined as dental caries, periodontal disease, and/or peri-implantitis). The interventions were psychological and/or behavioral... περισσότερα »
Different pulse modes of Er:YAG laser irradiation
: effects on bond strength achieved with self-etching primers: Abstract ObjectiveThe aim of this study was to compare the effects of different pulse modes of Er:YAG laser on shear bond strength (SBS) of orthodontic brackets bonded with self-etching primers (SEP) and phosphoric acid etching. Materials and methodsA total of 120 human mandibular third molars were randomly assigned to 3 groups of 40 specimens depending on the bonding procedure to be used. The groups were divided into two subgroups according to the pulse mode of the erbium-doped yttrium aluminum garnet (Er:YAG) lase...περισσότερα »
Three different Class II treatment modalities followed by fixed orthodontic therapy, using the American Board of Orthodontics Model Grading System (ABO-MGS).
Outcomes of different Class II treatments: Abstract ObjectiveThe aim of this study was to evaluate the clinical outcomes of three different Class II treatment modalities followed by fixed orthodontic therapy, using the American Board of Orthodontics Model Grading System (ABO-MGS). Materials and methodsAs a retrospective study, files of patients treated at postgraduate orthodontic clinics in different cities in Turkey was randomly selected. From 1684 posttreatment records, 669 patients were divided into three groups: 269 patients treated with extraction of two upper premolars,... περισσότερα »
Apertognathia : Etiology of anterior open bite
: a review: Abstract ObjectivesPresentation of different causes described in the literature for development of anterior apertognathia. MethodsA review about data referring to patients limited in their anterior tooth function through the positioning of their teeth has been performed. Electronic data bases, two libraries have been searched for information. Of the identified titles 357 articles and chapters were selected. 43 of these were considered. ResultsAetiology classifications are inconstant and author dependent, but mostly differentiated into genetic and environmental... περισσότερα »
Role of Helicobacter pylori Infection in Body Height of Adult Dyspeptic Patients
Role of Helicobacter pylori Infection in Body Height of Adult Dyspeptic Patients: Abstract Introduction The prevalence of *H. pylori* infection is high in underdeveloped countries and is associated with growth retardation. In the first half of the 20th century, Sardinia was an underdeveloped region; however, more recent development resulted in a decline in *H. pylori* infection. Because body height is correlated with health and nutritional status in childhood, the association among *H. pylori* infection and height was explored. Materials and Methods A retrospective observational stu... περισσότερα »
Gastric emptying of solids in children: reference values for the 13C-octanoic acid breath test
Abstract Background 99mTechnetium scintigraphy (99mTS) is the ‘gold standard’ for measuring gastric emptying (GE), but it is associated with a radiation exposure. For this reason, the 13C-octanoic acid breath test (13C-OBT) was developed for measuring GE of solids. The objective of this study was to determine normal values for gastric half-emptying time (t1/2GE) of solids in healthy children. Methods Gastric emptying of a standardized solid test meal consisting of a pancake evaluated with 99mTS and 13C-OBT was compared in 22 children aged between 1 and 15 years with upper gastroint... περισσότερα »
Endocannabinoid-related lipids are increased during an episode of cyclic vomiting syndrome
Abstract Background The endocannabinoid system and the hypothalamic–pituitary–adrenal axis are important neuromodulators of nausea and vomiting. This led us to hypothesize that patients with cyclic vomiting syndrome (CVS) have lower serum endocannabinoids (eCBs) and higher salivary cortisol and alpha amylase. Methods Serum eCBs and related lipids, *N*-oleoylethanolamine (OEA) and *N*-palmitoylethanolamide (PEA), and salivary cortisol, and alpha amylase (index of sympathetic nervous system activity) were measured in 22 CVS patients (age 40 ± 11, female = 17) in the well and sick pha... περισσότερα »
Cerebellar ataxia,areflexia,pes cavus,optic atrophy,and sensorineural hearing loss (CAPOS)
The Genetic Homogeneity of CAPOS Syndrome: Four New Cases With the c.2452G>A (p.Glu818Lys) Mutation in the ATP1A3 Gene.: Pediatr Neurol. 2016 ; Authors: Maas RP, Schieving JH, Schouten M, Kamsteeg EJ, van de Warrenburg BP Abstract BACKGROUND: The clinical syndrome of cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss (CAPOS) was first described 20 years ago, but it was only recently that whole exome sequencing unveiled the causative mutation in the ATP1A3 gene. We here present four patients from the seventh and eighth family identified worldwid... περισσότερα »
Inhibitors of Histone Deacetylases Attenuate Noise-Induced Hearing Loss
Inhibitors of Histone Deacetylases Attenuate Noise-Induced Hearing Loss: AbstractLoss of auditory sensory hair cells is the major pathological feature of noise-induced hearing loss (NIHL). Currently, no established clinical therapies for prevention or amelioration of NIHL are available. The absence of treatments is due to our lack of a comprehensive understanding of the molecular mechanisms underlying noise-induced damage. Our previous study indicates that epigenetic modification of histones alters hair cell survival. In this study, we investigated the effect of noise exposure on h... περισσότερα »
Atmospheric Pressure and Onset of Episodes of Menière’s Disease - A Repeated Measures Study
Atmospheric Pressure and Onset of Episodes of Menière’s Disease - A Repeated Measures Study: by Robert Gürkov, Ralf Strobl, Nina Heinlin, Eike Krause, Bernhard Olzowy, Christina Koppe, Eva Grill Background External changes of air pressure are transmitted to the middle and inner ear and may be used therapeutically in Menière’s disease, one of the most common vertigo disorders. We analyzed the possible relationship of atmospheric pressure and other meteorological parameters with the onset of MD vertigo episodes in order to determine whether atmospheric pressure changes play a role...περισσότερα »
Feasibility of a Recasting and Auditory Bombardment Treatment With Young Cochlear Implant Users
Feasibility of a Recasting and Auditory Bombardment Treatment With Young Cochlear Implant Users: Purpose There is little to guide clinicians in terms of evidence-based interventions for children with cochlear implants who demonstrate morpheme errors. This feasibility study tested the utility of a treatment targeting grammatical morpheme errors. Method Three children (ages 4–5 years) received Enhanced Conversational Recast treatment, a version of conversational recast treatment that focuses on a single morpheme error at a time, emphasizes attention to clinician input, and uses hig... περισσότερα »
Anti-Human HB-EGF Monoclonal Antibody
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy Apr 2016, Vol. 35, No. 2: 123-123. from Pharmacology via ola Kala on Inoreader http://ift.tt/1r0YBv5 via IFTTT
Monoclonal Antibodies MAM-2B11 MAM-6E10 and MAM-8G12 Against Aflatoxins
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy Apr 2016, Vol. 35, No. 2: 119-120. from Pharmacology via ola Kala on Inoreader http://ift.tt/1T0tgik via IFTTT
Neutralizing Monoclonal Antibody 3B1 Against Human Basic Fibroblast Growth Factor
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy Apr 2016, Vol. 35, No. 2: 122-122. from Pharmacology via ola Kala on Inoreader http://ift.tt/1r0YCyR via IFTTT
Congenital Deformities of the Face Head and Neck
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Facial plast Surg 2016; 32: 121-122 DOI: 10.1055/s-0036-1581139 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. Article in Thieme eJournals: Table of contents | Full text from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/242xwpl via IFTTT
Congenital Anomalies of the Nose
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Facial plast Surg 2016; 32: 133-141 DOI: 10.1055/s-0036-1582231 Congenital anomalies of the nose range from complete aplasia of the nose to duplications and nasal masses. Nasal development is the result of a complex embryologic patterning and fusion of multiple primordial structures. Loss of signaling proteins or failure of migration or proliferation can result in structural […]
Feeling Normal? Long-Term Follow-up of Patients with a Cleft LipPalate after Rhinoplasty with the Derriford Appearance Scale (DAS-59)
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Facial plast Surg 2016; 32: 219-224 DOI: 10.1055/s-0036-1579781 The stigma of nasal deformity due to a congenital cleft lip–palate has an undeniable influence on the affected patient’s life. It is therefore of interest to investigate if efforts to reduce esthetic and functional impairments by rhinoplasty (single or multiple) can result in an increased satisfaction with […]
State of the Art in Congenital Eyelid Deformity Management
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Facial plast Surg 2016; 32: 142-149 DOI: 10.1055/s-0036-1581049 The eyelids are crucial in maintaining the health of the ocular surface and have an important role in facial aesthetics. Interruption in eyelid development can lead to congenital eyelid deformities. This article reviews eyelid anatomy, the most common congenital eyelid abnormalities such as congenital ptosis, eyelid coloboma, […]
The Effects of Forearm and Perforator Flaps in Oral Cavity Reconstruction
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Facial plast Surg 2016; 32: 240-240 DOI: 10.1055/s-0036-1580592 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. Article in Thieme eJournals: Table of contents | Full text from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/242xttJ via IFTTT
Cleft Lip Repair: The Hybrid Subunit Method
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Facial plast Surg 2016; 32: 150-155 DOI: 10.1055/s-0036-1582227 The unilateral cleft lip repair is one of the most rewarding and challenging of plastic surgery procedures. Surgeons have introduced a variety of straight line, geometric, and rotation-advancement designs, while in practice the majority of North American surgeons have been using hybrids of the rotation-advancement techniques. The […]
Gracilis Free Muscle Transfer in the Treatment of Pediatric Facial Paralysis
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Facial plast Surg 2016; 32: 199-208 DOI: 10.1055/s-0036-1582248 Facial paralysis in children is a disabling functional and aesthetic issue. In cases where recovery is not expected, there are numerous options for reconstruction of the midface “smile.” At the Hospital for Sick Children in Toronto, Canada, we have been using a free functional gracilis muscle transfer. […]
State of the Art in Treating Velopharyngeal Dysfunction
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Facial plast Surg 2016; 32: 156-161 DOI: 10.1055/s-0036-1581048 Velopharyngeal dysfunction (VPD) is a condition that can greatly impact a child’s quality of life. The initial evaluation and workup of patients presenting with VPD is generally straightforward, consisting of history taking and physical examination, perceptual speech analysis, and objective techniques such as nasometry and speech endoscopy. […]
Technique in Cleft Rhinoplasty: The Foundation Graft
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Facial plast Surg 2016; 32: 213-218 DOI: 10.1055/s-0036-1578567 Secondary cleft rhinoplasty represents a particular surgical challenge. The authors have identified the deficit in skeletal projection of the cleft-sided piriform rim as an important contributor to the pathology. A graft is described to augment the piriform crest on the cleft side. This foundation graft is suture […]
Evidence-Based Management of Vascular Malformations
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Facial plast Surg 2016; 32: 162-176 DOI: 10.1055/s-0036-1581141 Vascular malformations of the head and neck are complex lesions that are notoriously difficult to manage. Treatment of these lesions often requires a multispecialty and multimodal approach. In the modern era of evidence-based medicine, it has become imperative for clinicians to incorporate evidence-based treatment algorithms into their […]
Seeing is believing: getting the best out of videolaryngoscopy
from Anaesthesia via ola Kala on Inoreader http://ift.tt/1SwjsT8 via IFTTT
Establishment of a Novel Monoclonal Antibody L6 Specific to NOB1
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy Apr 2016, Vol. 35, No. 2: 100-103. from Pharmacology via ola Kala on Inoreader http://ift.tt/1T0tdDr via IFTTT
Anti-E. coli Maltose Binding Protein Antibodies
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy Apr 2016, Vol. 35, No. 2: 121-121. from Pharmacology via ola Kala on Inoreader http://ift.tt/1r0YBuV via IFTTT
Ixekizumab: First Global Approval
Abstract Ixekizumab (Taltz®) is a humanised monoclonal immunoglobulin G antibody developed by Eli Lilly and Company that has been approved in the USA as a treatment for plaque psoriasis. Ixekizumab is a specific inhibitor of interleukin-17A (IL-17A), a pro-inflammatory cytokine that has a role in the development of several inflammatory conditions. This article summarizes the milestones in the development of ixekizumab leading to this first approval for plaque psoriasis. from Pharmacology via ola Kala on Inoreader http://ift.tt/1NlMi6h via IFTTT
Les secrets des associations synergiques de plantes facilitant le fonctionnement biologique hépatobiliaire
from Pharmacology via ola Kala on Inoreader http://ift.tt/1XIsrPc via IFTTT
Endometriosis of Extra-Abdominal Soft Tissues: A Tertiary Center Experience
While endometriosis, defined as the presence of endometrial tissue in extrauterine sites, is most frequently encountered within the peritoneal cavity, a small but significant proportion of cases occur at extra-abdominal soft tissue sites, particularly in relation to previous abdominal surgery. We reviewed the cases of endometriosis of soft tissue sites seen at a tertiary soft tissue center. All cases of extra-abdominal soft tissue endometriosis diagnosed at this institution over a 13-year period were reviewed, and clinical and pathologic findings were recorded. Forty-five patients... περισσότερα »
Mesonephric (Wolffian) Pseudoendometrioid Carcinoma of the Broad Ligament Arising From a Papillary Cystadenoma
This article describes the case of a 70-year-old woman with an adnexal cystadenocarcinoma located in the right broad ligament and displaying a striking resemblance to a well-differentiated endometrioid adenocarcinoma. The uniqueness of this pseudoendometrioid carcinoma lies in the fact that its mesonephric nature is revealed by the origin from a papillary cystadenoma of the broad ligament, where remnants of the mesonephric duct are seated, and the immunohistochemical profile, particularly a uniform negativity for estrogen and progesterone receptors, apical-luminal positivity for C... περισσότερα »
BRAF V600 mutations in Langerhans cell histiocytosis with a simple and unique assay
BRAF (V-raf murine sarcoma viral oncogene homolog B1) is a serine-threonine protein kinase involved in cell survival, proliferation, and differentiation. The most common missense mutation of BRAF (mainly V600E) c... from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/241afUU via IFTTT
Ageing ScherMontroll Transport
Abstract We study the properties of ageing Scher–Montroll transport in terms of a biased subdiffusive continuous time random walk in which the waiting times \(\tau \) between consecutive jumps of the charge carriers are distributed according to the power law probability \(\psi (t)\simeq t^{-1-\alpha }\) with \(0<\alpha <1\) . As we show, the dynamical properties of the Scher–Montroll transport depend on the ageing time span \(t_{a}\) between the initial preparation of the system and the start of the observation. The Scher–Montroll transport theory was originally shown to describe t... περισσότερα »
How to Set up a Sanger Sequencing Run Seq It Out #16
[image: youtube2.jpg] Familiar with how Sanger sequencing works in theory but want to know how it works in real life? Let me show you how it is done. Sanger Sequencing has moved from a very manual process using gels to being automated with capillary electrophoresis. As with all technologies, Sanger Sequencing has gotten easier through the years. Read the rest of this article The post How to Set up a Sanger Sequencing Run – Seq It Out #16 appeared first on Accelerating Science. from Biomedical Engineering via ola Kala on Inoreader http://ift.tt/1StQDDE via IFTTT
Sensitive measurement of nonlinear absorption and optical limiting in undoped and Fe-doped ZnO quantum dots using pulsed laser
Abstract Zinc oxide quantum dots (QDs) with Fe-doping at different concentrations were prepared by chemical co-precipitation method. The prepared QDs were characterized by UV–Vis spectroscopy, X-ray diffraction and Z-scan technique. The sizes of QDs were found to be within 4.6–6.6 nm range. The nonlinear parameters viz. two-photon absorption coefficient (βTPA) and two-photon absorption cross-section (σTPA) were extracted with the help of open aperture Z-scan technique using nanosecond Nd:YAG laser operating at wavelength 532 nm. Higher values of βTPA and σTPA for Fe doped ZnO impli... περισσότερα »
Experimental investigation of the fracture torque of orthodontic anchorage screws
Abstract Objectives In contrast to dental implants that remain in the bone, orthodontic anchorage screws serve as temporary anchorage for orthodontic tooth movement and are removed after completion of treatment. The aim of the present study was to evaluate the stability of various commercially available orthodontic anchorage screws against torsion. Materials and methods The torsional deflection of ten different orthodontic anchorage screws from different manufacturers [Ortho Easy Pin (Forestadent), Benefit, quattro (both PSM Medical Solutions), Vector TAS (Ormco), AbsoAnchor® (DEN... περισσότερα »
Effect of menstrual cycle on orthodontic pain perception
Abstract Background and objective The aim of this prospective, single-center, controlled clinical trial was to evaluate the effects of menstrual cycle phases on orthodontic pain perception. Materials and methods A total of 48 women between 16 and 20 years old with regular menstrual periods who were scheduled to undergo extraction of two upper first premolars for orthodontic treatment were enrolled in this study. Laceback ligatures were used to move canines distally. After activating the laceback ligatures, each patient completed a questionnaire in order to assess pain and quality... περισσότερα »
MRI vs. CT for orthodontic applications: comparison of two MRI protocols and three CT (multislice cone-beam industrial) technologies
Abstract Objectives To examine the relative usefulness and suitability of magnetic resonance imaging (MRI) in daily clinical practice as compared to various technologies of computed tomography (CT) in addressing questions of orthodontic interest. Methods Three blinded raters evaluated 2D slices and 3D reconstructions created from scans of two pig heads. Five imaging modalities were used, including three CT technologies—multislice (MSCT), cone-beam CT (CBCT), and industrial (µCT)—and two MRI protocols with different scan durations. Defined orthodontic parameters were rated one by ... περισσότερα »
Approaches to Modifying the Behavior of Clinicians who are Non-compliant with Antimicrobial Stewardship Program Guidelines
Managing the outlier physician requires differentiating deviation of norms from other outlier issues and their causes. Specific ASP planning, administrative and medical staff support, understanding why a problem exists, effective communication and staff acceptance of evidence-based recommendations are essential elements. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1TklMcS via IFTTT
Ceftazidime/Avibactam and Ceftolozane/Tazobactam: "Second generation" beta-Lactam/beta-Lactamase Combinations
Ceftolozane/tazobactam and ceftazidime/avibactam are second-generation β-lactam/β-lactamase combination antibiotics with *in vitro* activity against multi-drug resistant Gram-negative bacteria, including *Pseudomonas aeruginosa.* Both agents are approved for the treatment of complicated urinary tract infections and complicated intra-abdominal infections (when used with metronidazole). from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/26g4jtb via IFTTT
Role of Helicobacter pylori Infection in Body Height of Adult Dyspeptic Patients
Abstract Introduction The prevalence of *H. pylori* infection is high in underdeveloped countries and is associated with growth retardation. In the first half of the 20th century, Sardinia was an underdeveloped region; however, more recent development resulted in a decline in *H. pylori* infection. Because body height is correlated with health and nutritional status in childhood, the association among *H. pylori* infection and height was explored. Materials and Methods A retrospective observational study was conducted involving patients undergoing endoscopy for dyspepsia from 200... περισσότερα »
Glucagon receptor antagonist and GIP agonist combination for diet induced obese mice
Ablation of glucagon receptor signalling represents a potential treatment option for type 2 diabetes (T2DM). Additionally, activation of glucose-dependent insulinotropic polypeptide (GIP) receptor signalling also holds therapeutic promise for T2DM. Therefore, the present study examined both independent and combined metabolic actions of desHis1Pro4Glu9(Lys12PAL)-glucagon (glucagon receptor antagonist) and D-Ala2GIP (GIP receptor agonist), in diet induced obese… Continue reading Glucagon receptor antagonist and GIP agonist combination for diet induced obese mice
Neuroendocrine Carcinoma of the Cervix: Review of a Series of Cases and Correlation With Outcome
Introduction. Neuroendocrine carcinoma (NEC) of the cervix is associated with a poor prognosis despite multimodal treatment. The correct diagnosis of this tumor type is imperative to provide clinicians and patients with prognostic information and ensure that appropriate treatment is provided. Methods. A clinicopathological study was undertaken on all cervical tumors registered as NEC with the… Continue reading Neuroendocrine Carcinoma of the Cervix: Review of a Series of Cases and Correlation With Outcome
Mature Cystic Teratoma of the Ovary With Three Kinds of Entire Gastrointestinal Wall and Complete Bronchial Structure in a Pregnant Woman
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/26g2I6B via IFTTT
Pindborg Tumor Presenting as a Nasal Polyp: Immunohistology and Ultrastructural Features of a Rare Case With Review of the Literature
Calcifying epithelial odontogenic tumor, also known as Pindborg tumor, is a rare benign odontogenic tumor. This tumor predominantly involves the mandible, though the maxilla can also be involved in some cases. The involvement of maxillary sinuses, however, has been previously reported in only 8 case reports English literature. These patients chiefly presented with nasal obstruction… Continue reading Pindborg Tumor Presenting as a Nasal Polyp: Immunohistology and Ultrastructural Features of a Rare Case With Review of the Literature
Annulate Lamellae in a Desmoplastic Small Round Cell Tumor
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/26g2H2w via IFTTT
Endometriosis of Extra-Abdominal Soft Tissues: A Tertiary Center Experience
While endometriosis, defined as the presence of endometrial tissue in extrauterine sites, is most frequently encountered within the peritoneal cavity, a small but significant proportion of cases occur at extra-abdominal soft tissue sites, particularly in relation to previous abdominal surgery. We reviewed the cases of endometriosis of soft tissue sites seen at a tertiary soft… Continue reading Endometriosis of Extra-Abdominal Soft Tissues: A Tertiary Center Experience
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ELSEVIER from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sck3r9 via IFTTT
Evaluation of Eyelid Function and Aesthetics
The eyes and periocular area are the central aesthetic unit of the face. Facial aging is a dynamic process that involves skin, subcutaneous soft tissues, and bony structures. An understanding of what is perceived as youthful and beautiful is critical for success. Knowledge of the functional aspects of the eyelid and periocular area can identify… Continue reading Evaluation of Eyelid Function and Aesthetics
Functional and Cosmetic Eyelid Surgery
FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Sck0vp via IFTTT
Correction of Eyelid Crease Asymmetry and Ptosis
Upper eyelid ptosis and crease abnormalities can lead to significant cosmetic deformity. An intimate knowledge of the anatomic structures responsible for eyelid height, contour, and pretarsal show will allow precise surgical correction. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/242f6Fn via IFTTT
Local Injection of Bone Mesenchymal Stem Cells and Fibrin Glue Promotes the Repair of Bone Atrophic Nonunion In Vivo
Abstract Introduction This study aimed to evaluate the efficacy of local injection of bone mesenchymal stem cells (BMSCs) and fibrin glue in the treatment of atrophic nonunion in an animal model. Methods Thirty-six male Lewis rats were randomly assigned into three groups: Group A (control group), Group B (atrophic nonunion group), and Group C (experimental group). All the rats underwent femoral osteotomy of the right hind limb, and stabilized with a custom-designed external fixator. Atrophic nonunion of the rats in Group B and C was induced by cauterization of the periosteum and ... περισσότερα »
Biomechanical optimization of subject-specific implant positioning for femoral head resurfacing to reduce fracture risk
Peri-prosthetic femoral neck fracture after femoral head resurfacing can be either patient-related or surgical technique-related. The study aimed to develop a patient-specific finite element modelling technique that can reliably predict an optimal implant position and give minimal strain in the peri-prosthetic bone tissue, thereby reducing the risk of peri-prosthetic femoral neck fracture. The subject-specific finite element modelling was integrated with optimization techniques including design of experiments to best possibly position the implant for achieving minimal strain for fe... περισσότερα »
Regenerative approaches for the cornea
Abstract The cornea is the transparent front part of the eye that transmits light to the back of the eye to generate vision. Loss of corneal transparency, if irreversible, leads to severe vision loss or blindness. For decades, corneal transplantation using human donor corneas has been the only option for treating corneal blindness. Despite recent improvement in surgical techniques, donor cornea transplantation remains plagued by risks of suboptimal optical results and visual acuity, immune rejection and eventually graft failure. Furthermore, the demand for suitable donor corneas i... περισσότερα »
Update on the pharmacological treatment of adult myositis
Abstract The management of patients with idiopathic inflammatory myopathy (IIM) remains a challenge given the systemic features beyond active myositis. That is, recognizing the inflammatory arthropathy, varying dermatomyositis rashes, and overt and occult features of interstitial lung disease in addition to myositis adds to the complexity of diagnosis and treatment of IIM. However, clinicians now have available many more immunosuppressive drugs as well as biologic agents for use in patients with myositis and other autoimmune diseases. Here, the use of these agents is reviewed and ... περισσότερα »
Akiva et al.In vivo studies of mineral deposition in zebrafish Tail Fins
IBMS BoneKEy 13 doi: 10.1038/bonekey.2016.32 from #Medicine via ola Kala on Inoreader http://ift.tt/242xAWa Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Reyes Fernandez et al. The relationship between calcium metabolism and bone during growth
IBMS BoneKEy 13 doi: 10.1038/bonekey.2016.38 from #Medicine via ola Kala on Inoreader http://ift.tt/1rmIKr5 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Kir et al. A common mechanism for tumor-induced cachexia and CKD
IBMS BoneKEy 13 doi: 10.1038/bonekey.2016.37 from #Medicine via ola Kala on Inoreader http://ift.tt/242xy0m Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Hoshino et al. Metastasis to specific organs is determined by tumor exosome integrins
IBMS BoneKEy 13 doi: 10.1038/bonekey.2016.27 from #Medicine via ola Kala on Inoreader http://ift.tt/1rmIKqU Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Hwang et al. GLDN gene associated with heel bone strength in Korean populations
IBMS BoneKEy 13 doi: 10.1038/bonekey.2016.36 from #Medicine via ola Kala on Inoreader http://ift.tt/242xAp5 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Schroder et al. Disrupting the molecular clock in muscle also affects bone
IBMS BoneKEy 13 doi: 10.1038/bonekey.2016.33 from #Medicine via ola Kala on Inoreader http://ift.tt/1rmIKap Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Chen et al. inhibition of RANKL could treat osteosarcoma
IBMS BoneKEy 13 doi: 10.1038/bonekey.2016.35 from #Medicine via ola Kala on Inoreader http://ift.tt/242xA8y Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Mitchell et al. Bone density in children and genetic loci for adult bone fragility
IBMS BoneKEy 13 doi: 10.1038/bonekey.2016.28 from #Medicine via ola Kala on Inoreader http://ift.tt/1rmIJU0 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Zhou et al. Predicting genetic risk of femoral fracture: A novel genetic risk score
IBMS BoneKEy 13 doi: 10.1038/bonekey.2016.34 from #Medicine via ola Kala on Inoreader http://ift.tt/242xxcN Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Qundos et al. Autocrine motility factor receptor: A novel biomarker for osteoporosis
IBMS BoneKEy 13 doi: 10.1038/bonekey.2016.25 from #Medicine via ola Kala on Inoreader http://ift.tt/1rmIGrj Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Immunity to hepatitis A and B persists for at least 15 years after immunisation of adolescents with a combined hepatitis A and B vaccine
[image: alertIcon.gif] Publication date: Available online 20 April 2016 *Source:*Vaccine Author(s): Jiri Beran, Olivier Van Der Meeren, Maarten Leyssen, Priya D'silva BackgroundThe exact duration of antibody persistence to hepatitis A and B and the need for booster dosing following primary immunisation remains undefined. A long-term study was designed to follow antibody persistence and immune memory on an annual basis for up to 15 years following vaccination during adolescence.MethodsSubjects received a combined hepatitis A and B vaccine (Twinrix™, GSK Vaccines, Belgium) at 12–15 ye... περισσότερα »
The generation of memory B cells is maintained but the antibody response is not in the elderly after repeated influenza immunizations
[image: S0264410X.gif] Publication date: Available online 20 April 2016 *Source:*Vaccine Author(s): Daniela Frasca, Alain Diaz, Maria Romero, Bonnie B. Blomberg The success of a vaccine in inducing a protective antibody response depends on the longevity of both long-lived plasma cells (PC) and memory B cells. We have previously shown that the in vivo antibody response to a new influenza vaccine, the ex vivo plasmablast response, the in vitro B cell function, measured by AID (activation-induced cytidine deaminase), and the transcription factor E47, are significantly associated and dec...περισσότερα »
Effect of introduction of pentavalent vaccine as replacement for DiphtheriaTetanusPertussis and Hepatitis B vaccines on vaccination uptake in a health facility in Nigeria
[image: S0264410X.gif] Publication date: Available online 20 April 2016 *Source:*Vaccine Author(s): Ayebo Evawere Sadoh, Damian Uchechukwu Nwaneri, Bamidele Charity Ogboghodo, Wilson Ehidiamen Sadoh BackgroundThe introduction of a new vaccine into an immunization programme may affect the immunization system negatively or positively. The aim of this study is to determine the effect of the introduction of the pentavalent vaccine as replacement for DTP and Hepatitis B vaccines on timeliness, completion of the schedule and dropout rates among children attending a health facility.Methodo...περισσότερα »
Neuroendocrine Carcinoma of the Cervix: Review of a Series of Cases and Correlation With Outcome
*Introduction*. Neuroendocrine carcinoma (NEC) of the cervix is associated with a poor prognosis despite multimodal treatment. The correct diagnosis of this tumor type is imperative to provide clinicians and patients with prognostic information and ensure that appropriate treatment is provided. *Methods*. A clinicopathological study was undertaken on all cervical tumors registered as NEC with the West Midlands Cancer Intelligence Unit between January 1, 1998 and December 31, 2009. Of the 45 cases diagnosed during the study period, the tumor samples of 41 cases were traced, anonymi...περισσότερα »
Mature Cystic Teratoma of the Ovary With Three Kinds of Entire Gastrointestinal Wall and Complete Bronchial Structure in a Pregnant Woman
from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/26g2I6B via IFTTT
Pindborg Tumor Presenting as a Nasal Polyp: Immunohistology and Ultrastructural Features of a Rare Case With Review of the Literature
Calcifying epithelial odontogenic tumor, also known as Pindborg tumor, is a rare benign odontogenic tumor. This tumor predominantly involves the mandible, though the maxilla can also be involved in some cases. The involvement of maxillary sinuses, however, has been previously reported in only 8 case reports English literature. These patients chiefly presented with nasal obstruction along with epistaxis or proptosis in rare cases. However, a primary presentation as nasal polyp is unheard of. We present a rare case of calcifying epithelial odontogenic tumor presenting as a nasal pol... περισσότερα »
Annulate Lamellae in a Desmoplastic Small Round Cell Tumor
from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/26g2H2w via IFTTT
Endometriosis of Extra-Abdominal Soft Tissues: A Tertiary Center Experience
While endometriosis, defined as the presence of endometrial tissue in extrauterine sites, is most frequently encountered within the peritoneal cavity, a small but significant proportion of cases occur at extra-abdominal soft tissue sites, particularly in relation to previous abdominal surgery. We reviewed the cases of endometriosis of soft tissue sites seen at a tertiary soft tissue center. All cases of extra-abdominal soft tissue endometriosis diagnosed at this institution over a 13-year period were reviewed, and clinical and pathologic findings were recorded. Forty-five patients... περισσότερα »
Mesonephric (Wolffian) Pseudoendometrioid Carcinoma of the Broad Ligament Arising From a Papillary Cystadenoma
This article describes the case of a 70-year-old woman with an adnexal cystadenocarcinoma located in the right broad ligament and displaying a striking resemblance to a well-differentiated endometrioid adenocarcinoma. The uniqueness of this pseudoendometrioid carcinoma lies in the fact that its mesonephric nature is revealed by the origin from a papillary cystadenoma of the broad ligament, where remnants of the mesonephric duct are seated, and the immunohistochemical profile, particularly a uniform negativity for estrogen and progesterone receptors, apical-luminal positivity for C... περισσότερα »
Fiber knob domain lacking the shaft sequence but fused to a coiled coil is a candidate subunit vaccine against egg-drop syndrome
[image: S0264410X.gif] Publication date: Available online 20 April 2016 *Source:*Vaccine Author(s): Tetsuya Harakuni, Kiyohiko Andoh, Ryu-ichi Sakamoto, Yukihiro Tamaki, Takeshi Miyata, Hirotaka Uefuji, Ken-ichi Yamazaki, Takeshi Arakawa Egg-drop syndrome (EDS) virus is an avian adenovirus that causes a sudden drop in egg production and in the quality of the eggs when it infects chickens, leading to substantial economic losses in the poultry industry. Inactivated EDS vaccines produced in embryonated duck eggs or cell culture systems are available for the prophylaxis of EDS. However, ...περισσότερα »
