Head and Neck Medicine by Alexandros G.Sfakianakis: 12/17/15

Πέμπτη 17 Δεκεμβρίου 2015

OtoRhinoLaryngology & Medicine,New Articles,December 18th,2015

Immunogenic Stimulus for Germline Precursors of Antibodies that Engage the Influenza Hemagglutinin Receptor-Binding Site

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 10 δευτερόλεπτα

Publication date: Available online 17 December 2015 Source:Cell Reports Author(s): Aaron G. Schmidt, Khoi T. Do, Kevin R. McCarthy, Thomas B. Kepler, Hua-Xin Liao, M. Anthony Moody, Barton F. Haynes, Stephen C. Harrison Influenza-virus antigenicity evolves to escape host immune protection. Antibody lineages within individuals evolve in turn to increase affinity and hence potency. Strategies […]

Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity

Publication date: Available online 17 December 2015 Source:Cell Reports Author(s): Akinori Takahashi, Shungo Adachi, Masahiro Morita, Miho Tokumasu, Tohru Natsume, Toru Suzuki, Tadashi Yamamoto Uncoupling protein 1 (Ucp1) contributes to thermogenesis, and its expression is regulated at the transcriptional level. Here, we show that Ucp1 expression is also regulated post-transcriptionally. In inguinal white adipose tissue […]

FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1

Publication date: Available online 17 December 2015 Source:Cell Reports Author(s): Bin Wang, Lin Pan, Manyi Wei, Qiong Wang, Wen-Wen Liu, Nuoxin Wang, Xing-Yu Jiang, Xu Zhang, Lan Bao Subcellular targeting and local translation of mRNAs are critical for axon development. However, the precise local control of mRNA translation requires investigation. We report that the Fmr1-encoded […]

An Amacrine Cell Circuit for Signaling Steady Illumination in the Retina

Publication date: Available online 17 December 2015 Source:Cell Reports Author(s): Jason Jacoby, Yongling Zhu, Steven H. DeVries, Gregory W. Schwartz Decades of research have focused on the circuit connectivity between retinal neurons, but only a handful of amacrine cells have been described functionally and placed in the context of a specific retinal circuit. Here, we […]

ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation

Publication date: Available online 17 December 2015 Source:Cell Reports Author(s): Yuko Atsumi, Yusuke Minakawa, Masaya Ono, Sachiko Dobashi, Keitaro Shinohe, Akira Shinohara, Shunichi Takeda, Masatoshi Takagi, Nobuhiko Takamatsu, Hitoshi Nakagama, Hirobumi Teraoka, Ken-ichi Yoshioka In response to DNA double-strand breaks (DSBs), H2AX is rapidly phosphorylated at Ser139 to promote DSB repair. Here we show that […]

Directed Migration of Pulmonary Neuroendocrine Cells toward Airway Branches Organizes the Stereotypic Location of Neuroepithelial Bodies

Publication date: Available online 17 December 2015 Source:Cell Reports Author(s): Masafumi Noguchi, Kenta Sumiyama, Mitsuru Morimoto The airway epithelium consists of diverse cell types, including neuroendocrine (NE) cells. These cells are thought to function as chemoreceptors and as a component of the stem cell niche as well as the cells of origin in small-cell lung […]

Nuclear Retention of mRNA in Mammalian Tissues

Publication date: Available online 17 December 2015 Source:Cell Reports Author(s): Keren Bahar Halpern, Inbal Caspi, Doron Lemze, Maayan Levy, Shanie Landen, Eran Elinav, Igor Ulitsky, Shalev Itzkovitz mRNA is thought to predominantly reside in the cytoplasm, where it is translated and eventually degraded. Although nuclear retention of mRNA has a regulatory potential, it is considered […]

Toll-like Receptor 2 Activation Promotes Tumor Dendritic Cell Dysfunction by Regulating IL-6 and IL-10 Receptor Signaling

Publication date: Available online 17 December 2015 Source:Cell Reports Author(s): Michael Tang, Jun Diao, Hongtao Gu, Ismat Khatri, Jun Zhao, Mark S. Cattral Although dendritic cell (DC) dysfunction in cancer is a well-recognized consequence of cancer-associated inflammation that contributes to immune evasion, the mechanisms that drive this process remain elusive. Here, we show the critical […]

Intratumoral LIGHT Restores Pericyte Contractile Properties and Vessel Integrity

Publication date: Available online 17 December 2015 Source:Cell Reports Author(s): Anna Johansson-Percival, Zhi-Jie Li, Devina D. Lakhiani, Bo He, Xiao Wang, Juliana Hamzah, Ruth Ganss Normalization of the tumor vasculature is an emerging concept shown to improve anti-cancer therapy. However, there are currently no clinical interventions that effect long-lasting normalization. Here, we have developed a […]

Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria

Publication date: Available online 17 December 2015 Source:Cell Reports Author(s): Bruno Coelho Rocha, Pedro Elias Marques, Fabiana Maria de Souza Leoratti, Caroline Junqueira, Dhelio Batista Pereira, Lis Ribeiro do Valle Antonelli, Gustavo Batista Menezes, Douglas Taylor Golenbock, Ricardo Tostes Gazzinelli Neutrophils are the most abundant leukocyte population in the bloodstream, the primary compartment of Plasmodium […]

A NOXA/MCL-1 Imbalance Underlies Chemoresistance of Malignant Rhabdoid Tumor Cells

Alexandros G. SfakianakisστοEvolutionary PhysiologyΠριν από 1 λεπτό

Abstract Malignant rhabdoid tumor (MRT) is a rare aggressive pediatric cancer characterized by inactivation of SNF5, a core subunit of SWI/SNF complexes. Previously, we showed that SNF5 contributes to transcriptional activation of NOXA, a pro-apoptotic protein that binds and inhibits the anti-apoptotic protein MCL-1. In this study, we found that NOXA expression was downregulated in MRT cell lines as well as in clinical MRT samples and that ectopically expressed NOXA bound MCL-1 and increased the sensitivity of MRT cell lines to doxorubicin (DOX) by promoting apoptosis. Consistent w... περισσότερα »

Let-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells

Alexandros G. SfakianakisστοEvolutionary PhysiologyΠριν από 1 λεπτό

Abstract Osteosarcoma (OS), an aggressive highly invasive and metastatic bone-malignancy, shows therapy resistance and recurrence, two features that likely depend on cancer stem cells (CSCs), which hold both self-renewing and malignant potential. So, effective anticancer therapies against OS should specifically target and destroy CSCs. We previously found that the let-7d microRNA was downregulated in the 3AB-OS-CSCs, derived from the human OS-MG63 cells. Here, we aimed to assess whether let-7d modulation affected tumorigenic and stemness properties of these OS-CSCs. We found that ...περισσότερα »

Effects of a Sublethal and Transient Stress of the Endoplasmic Reticulum on the Mitochondrial Population

Alexandros G. SfakianakisστοEvolutionary PhysiologyΠριν από 1 λεπτό

Abstract Endoplasmic reticulum (ER) and mitochondria are not discrete intracellular organelles but establish close physical and functional interactions involved in several biological processes including mitochondrial bioenergetics, calcium homeostasis, lipid synthesis and the regulation of apoptotic cell death pathways. As many cell types might face a transient and sublethal ER stress during their lifetime, it is thus likely that the adaptive UPR response might affect the mitochondrial population. The aim of this work was to study the putative effects of a non-lethal and transient ... περισσότερα »

Head and Neck Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 λεπτό

Incidence of Suicide in Patients With Head and Neck Cancer Importance Suicide rates among patients with cancer in the US are significantly higher than those of the general population. To our knowledge, large cohort studies examining suicide rates among patients with head and neck cancer have not been performed. Objective To identify incidence rate, trends, and risk factors of suicide in patients with cancer of the head and neck. Design, Setting, and Participants This was a retrospective cohort study of geographic areas served by the Surveillance, Epidemiology, and End Resu... περισσότερα »

Treatment Outcomes for T4 Oropharyngeal Squamous Cell Carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Treatment Outcomes for T4 Oropharyngeal Squamous Cell Carcinoma Importance Little is known about treatment outcomes for T4 oropharyngeal squamous cell carcinoma (OPSCC), particularly in the era of human papillomavirus (HPV)-related disease. Objective To evaluate oncologic outcomes for T4 OPSCC treated with primary surgical and nonsurgical therapies. Design, Setting, and Participants Retrospective cohort study of 131 patients from a single academic hospital, who were treated for T4a or T4b OPSCC (with any N stage and without distant metastatic disease at presentation) betw...περισσότερα »

Cost of Hospice Use in Terminally Ill Patients With Head & Neck Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Cost of Hospice Use in Terminally Ill Patients With Head & Neck Cancer Importance Hospice care has been suggested as a way to preserve dignity and to lower costs at the end of life, which may be particularly important for patients with head and neck cancer because this disease is associated with considerable morbidity and a high mortality risk. Objectives To use data from the Surveillance, Epidemiology, and End Results (SEER)–Medicare linked database to estimate monthly costs of all services used during the last months of life by patients with oral cavity and pharyngeal cance... περισσότερα »

Margin Sampling Technique in Early Oral Tongue Squamous Cell Carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Margin Sampling Technique in Early Oral Tongue Squamous Cell Carcinoma Importance Positive margins are associated with poor prognosis among patients with oral tongue squamous cell carcinoma (SCC). However, wide variation exists in the margin sampling technique. Objective To determine the effect of the margin sampling technique on local recurrence (LR) in patients with stage I or II oral tongue SCC. Design, Setting, and Participants A retrospective study was conducted from January 1, 1986, to December 31, 2012, in 5 tertiary care centers following tumor resection and electi... περισσότερα »

Ideal Candidate Selection for Surgical Salvage of HNSCC

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Ideal Candidate Selection for Surgical Salvage of HNSCC Importance Salvage surgery for recurrent head and neck squamous cell carcinoma (HNSCC) carries substantial risks of morbidity and mortality. Risk factors for death within 1 year should be better defined. Objectives To report preoperative oncologic prognostic factors predictive of short-term (<1 year) survival after salvage surgery in patients with HNSCC, to assess whether preoperative age and comorbidity predicts 1-year mortality, and to report hospital courses after salvage surgery within 1 year. Design, Setting, and... περισσότερα »

Role of the Head and Neck Surgeon in Health Care Reform

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Role of the Head and Neck Surgeon in Health Care Reform The landscape of health care delivery in the United States is in the midst of irreversible and progressive changes that present tremendous opportunities to do maximal good for patients. Clinicians must embrace this opportunity to ensure this redesign is done properly and to the benefit of patients—not the bottom line of the health system. This sweeping change in health care will also align the benefits of preventive care and public health with the economic health of health systems for the first time. Clincians will be incent... περισσότερα »

Transoral Robotic Surgery in Oropharyngeal Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Transoral Robotic Surgery in Oropharyngeal Cancer Importance Large patient cohorts are necessary to validate the efficacy of transoral robotic surgery (TORS) in the management of head and neck cancer. Objectives To review oncologic outcomes of TORS from a large multi-institutional collaboration and to identify predictors of disease recurrence and disease-specific mortality. Design, Setting, and Participants A retrospective review of records from 410 patients undergoing TORS for laryngeal and pharyngeal cancers from January 1, 2007, through December 31, 2012, was performed.... περισσότερα »

Surgery vs Nonsurgical Therapy for Advanced Supraglottic Laryngeal Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Surgery vs Nonsurgical Therapy for Advanced Supraglottic Laryngeal Cancer Importance Nonsurgical treatment of advanced supraglottic laryngeal cancer is widely used as part of a larynx preservation protocol. However, recent studies have suggested that nonsurgical treatment may be associated with inferior survival. Furthermore, it is not clear whether preservation of the larynx provides superior voice or swallowing function in the long term. Objective To test the hypothesis that surgical treatment of advanced-stage squamous cell carcinoma of the supraglottic larynx is associated... περισσότερα »

Jugular Paragangliomas – Resection Techniques

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 4 δευτερόλεπτα

The prerequisites for surgical resection of tumours arising in the jugular foramen are adequate access, control of the major vessels and the ability to move the facial nerve safely out of the operative field if necessary. Without it the surgeon risks catastrophic haemorrhage, cranial nerve palsies that might have been avoided and insufficient access to […]

Paraganglioma – Role of Preoperative Evaluation and Endovascular Embolization

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 4 δευτερόλεπτα

An understanding of the vascular architecture of paragangliomas can aid in both diagnosis and treatment. There is a growing role for vascular evaluation and intervention of these highly vascular tumors. This article addresses the specifics of the vasculature of paragangliomas, with focus on preoperative imaging, preoperative balloon test occlusion and endovascular embolization. The authors present […]

Treatment Of Carotid Paraganglioma

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 4 δευτερόλεπτα

Carotid paragangliomas, commonly known as carotid body tumors, are the most commonly reported head and neck paragangliomas. They are slow-growing and always associated with the carotid arteries and adjacent nerves. They are rarely malignant. The estimates for familial transmission of this tumor range from 30 to 50%. When multiple paragangliomas are present, the most common […]

Ancient Hybridization and an Irish Origin for the Modern Polar Bear Matriline

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 4 δευτερόλεπτα

Current biology : CB from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Yp5C2d via IFTTT

FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 5 δευτερόλεπτα

Olfaction following endoscopic skull base surgery.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 5 δευτερόλεπτα

Spontaneous angina bullosa hemorrhagica

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 5 δευτερόλεπτα

Acta Otorrinolaringológica Española Available online 17 December 2015 In Press, Corrected Proof — Note to users Imágenes en otorrinolaringología Dos casos de angina bullosa hemorrágica espontánea Two cases of spontaneous angina bullosa hemorrhagica Belén Lozano-Masdemont, , Marta Bergón-Sendín, Ricardo Suárez-Fernández Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España from #Med Blogs by Alexandros …

An Amacrine Cell Circuit for Signaling Steady Illumination in the Retina

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 5 δευτερόλεπτα

Maxillary sinus hemangioma

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 5 δευτερόλεπτα

Case report Maxillary sinus hemangioma: usefulness of embolization according to classification Hemangioma de seio maxilar: utilidade da embolização de acordo com a classificação Hisashi Hasegawaa, Hiroumi Matuzakia, , , Tohru Furusakaa, Takeshi Oshimaa, Shinobu Masudab, Toshiyuki Unnoc, Osamu Abec aDepartment of Otorhinolaryngology, Head and Neck Surgery, Nihon University School of Medicine, Japan bDepartment of Pathology, …

ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 5 δευτερόλεπτα

Neuro-oncology family caregiving: review and directions for future research

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 5 δευτερόλεπτα

CNS Oncology Ahead of Print. from Cancer via ola Kala on Inoreader http://ift.tt/1Pcq9qj via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PaemGT via IFTTT

Directed Migration of Pulmonary Neuroendocrine Cells toward Airway Branches Organizes the Stereotypic Location of Neuroepithelial Bodies

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 5 δευτερόλεπτα

Laronidase treatment in otolaryngological manifestations of patients with mucopolysaccharidosis

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 5 δευτερόλεπτα

The impact of via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 17 December 2015 Source:Brazilian Journal of Otorhinolaryngology Author(s): Ana Paula Fiuza Funicello Dualibi, Ana Maria Martins, Gustavo Antônio Moreira, Marisa Frasson de Azevedo, Reginaldo Raimundo Fujita, Shirley Shizue Nagata Pignatari IntroductionMucopolysaccharidosis (MPS) is a lysosomal storage disease caused by deficiency of …

Nuclear Retention of mRNA in Mammalian Tissues

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 5 δευτερόλεπτα

Time for a Change

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα

Time for a Change: As my tenure as journal editor comes to a close at the end of December, I felt compelled to share with our readership a few final words. It has been an educational and interesting opportunity to have been chosen as the editor by Cathy DeAngelis, MD, more than 10 years ago and to be able to continue in that role under her successor, Howard Bauchner, MD. As my tenure as journal editor comes to a close at the end of December, I felt compelled to share with our readership a few final words. It has been an educational and interesting opportunity to have been chosen a... περισσότερα »

Phylodynamics of the HIV-1 CRF02_AG clade in Cameroon

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Yp5BLK via IFTTT

Dual-Action Inhibitors of HIF Prolyl Hydroxylases That Induce Binding of a Second Iron Ion

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα

Organic & biomolecular chemistry from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Yp5DDl via IFTTT

What is the effect of unemployment on all-cause mortality? A cohort study using propensity score matching

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα

European journal of public health from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Yp5Bvf via IFTTT

AIDing cancer treatment: Reducing AID activity via HSP90 inhibition

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα

European journal of immunology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YlFYAE via IFTTT

A neural mechanism underlying failure of optimal choice with multiple alternatives

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα

Nature neuroscience from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YlFVoC via IFTTT

Selective inhibition of the mitochondrial permeability transition pore protects against neuro-degeneration in experimental multiple sclerosis. Cell Biology

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα

The mitochondrial permeability transition pore (PT pore) is a recognised drug target for neurodegenerative conditions such as multiple sclerosis (MS) and for ischaemia-reperfusion injury in the brain and heart. The peptidylprolyl isomerase, cyclophilin D (CypD, ppif) is a positive regulator of the pore and genetic downregulation or knockout improves outcomes in disease models. Current inhibitors […]

Mambalgin-1 pain-relieving peptide: stepwise solid-phase synthesis, crystal structure and functional domain for acid-sensing ion channel 1a inhibition Protein Structure and Folding

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα

Mambalgins are peptides isolated from mamba venom that specifically inhibit a set of acid-sensing ion channels (ASICs) to relieve pain. We show here the first full stepwise solid-phase peptide synthesis of mambalgin-1 and confirm the biological activity of the synthetic toxin both in vitro and in vivo. We also report the determination of its 3D […]

Structural correlation of the neck coil with the CC1-FHA tandem for active kinesin-3 KIF13A Protein Structure and Folding

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα

Processive kinesin motors often contain a coiled-coil neck that controls the directionality and processivity. However, the neck coil (NC) of kinesin-3 is too short to form a stable coiled-coil dimer. Here, we found that the CC1-FHA tandem (that is connected to NC by P390) of kinesin-3 KIF13A assembles as an extended dimer. With the removal […]

Type I interferon signaling is decoupled from specific receptor orientation through lenient requirements of the transmembrane domain Signal Transduction

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα

Type I interferons serve as first line of defense against pathogen invasion. Binding of IFNs to its receptors, IFNAR1 and IFNAR2, is leading to activation of the IFN response. To determine whether structural perturbations observed during binding are propagated to the cytoplasmic domain, multiple mutation were introduced to the transmembrane helix (TMD) and its surrounding. […]

HIV-1 Vpr Protein Induces Proteasomal Degradation of Chromatin-associated Class I HDACs to Overcome Latent Infection of Macrophages Protein Synthesis and Degradation

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα

Mechanisms underlying HIV-1 latency remain among the most crucial questions that need to be answered in order to adopt strategies for purging the latent viral reservoirs. Here we show that HIV-1 accessory protein Vpr induces depletion of class I HDACs, including HDAC1, 2, 3, and 8, to overcome latency in macrophages. We found that Vpr […]

Antibiotic Prophylaxis in Head and Neck Free Flap Reconstruction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα

Antibiotic Prophylaxis in Head and Neck Free Flap Reconstructioncontaminated head and neck procedures. Importance Evidence supports short courses of perioperative antibiotics for patients receiving minor head and neck procedures. Few studies have addressed antibiotic prophylaxis for patients undergoing free flap reconstruction of head and neck defects. Objective To determine ideal antibiotic prophylaxis in patients undergoing head and neck free flap reconstruction. Design, Setting, and Participants Retrospective cohort study of 427 adults receiving free flap reconstructio... περισσότερα »

Aggressive Palliation and Survival in Anaplastic Thyroid Carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα

Aggressive Palliation and Survival in Anaplastic Thyroid Carcinoma *Importance* Anaplastic thyroid carcinoma is an undifferentiated aggressive tumor with a high rate of regional and distant spread and a grave prognosis (median survival, 3 months) with no standardized treatment. *Objective* To review the effect of an active treatment policy on the outcome of anaplastic thyroid carcinoma. *Design, Setting, and Participants* Retrospective comparative study of all patients diagnosed as having anaplastic thyroid carcinoma and undergoing treatment from January 1, 2008, through Decembe... περισσότερα »

The detection of chronic airways disease

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα

Informal Health Provider and Practical Approach to Lung Health interventions to improve the detection of chronic airways disease and tuberculosis at primary care level in Malawi: study protocol for a randomised controlled trial: Background: In developing countries like Malawi, further investigation is rare after patients with chronic cough test negative for tuberculosis. Chronic airways disease has presentations that overlap with tuberculosis. However, chronic airways disease is often unrecognised due to a lack of diagnostic services. Within developing countries, referral systems at ... περισσότερα »

Light cupula of the horizontal semicircular canal occurring alternately on both sides: a case report

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα

Light cupula of the horizontal semicircular canal occurring alternately on both sides: a case report Abstract Background The light cupula is a condition wherein the cupula of the semicircular canal has a lower specific gravity than its surrounding endolymph. It is characterized by a persistent geotropic direction-changing positional nystagmus in the supine head-roll test, and the identification of a null plane with slight head-turning to either side. Case presentation This study describes a case of recurring light cupula that occurred alternately on both sides. At the firs... περισσότερα »

CINGLE-trial: cochlear implantation for siNGLE-sided deafness

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα

CINGLE-trial: cochlear implantation for siNGLE-sided deafness, a randomised controlled trial and economic evaluation Abstract Background Individuals with single-sided deafness (SSD) have problems with speech perception in noise, localisation of sounds and with communication and social interaction in their daily life. Current treatment modalities (Contralateral Routing of Sound systems [CROS] and Bone Conduction Devices [BCD]) do not restore binaural hearing. Based on low level of evidence studies, CROS and BCD do not improve speech perception in noise or sound localisation. I...περισσότερα »

TAbstract Background Chronic Suppurative Otitis Media (CSOM) is the commonest cause of preventable deafness, affecting 164 million people worldwide, 90 % of whom live in low resource countries, such as Nepal. Simple, inexpensive treatment of acute otitis media can prevent the development of CSOM and its sequelae: deafness, abscess, encephalitis, and, rarely, death. CSOM is a disease of poverty and its social determinants: low parental education, overcrowding, poor hygiene and malnutrition. Previous studies have established economic, socio-cultural and geographic barriers to care seeking for childhood illness in the developing world and, in particular, in Nepal. The ultimate aim of this research is to improve the ear health of the children in Jumla, Nepal. The primary outcome is an increase in mother’s knowledge, attitude and practice regarding ear disease in their children. The secondary outcome is a reduction in the prevalence of CSOM in their children. Methods/design Using 56 existing women’s self-help groups, sample size, adjusting for clustering and data analysis, is set at 15 groups per arm. A baseline survey of 30 randomly selected groups will be performed, consisting of a knowledge, attitude and practice questionnaire aimed at women who participate in self-help groups, as well as examination of their children’s ears. This will be followed by random allocation, stratified by geography, into 15 intervention and 15 control groups. The intervention groups will participate in three interactive educational sessions at their regular monthly meetings based on World Health Organisation Primary Ear and Hearing Resource, Basic Level. The control groups will continue their usual monthly group meetings. At 12 months, a follow-up assessment of both control and intervention groups will be performed, with a repeat women’s survey and repeat ear examination of the children. Data analysis will be by intention to treat and clustering will be considered at every stage. Cluster level data will be analysed using t-test and individual level data using mixed effects linear regression and logistic regression random effects model as appropriate. Discussion Despite its remote location, Jumla has a vibrant network of health posts and community workers. This project uses existing, local resources and will be undertaken in a way that is consistent with the cultural understanding of the local community in Jumla and acceptable to local care-givers. Trial registration Australia and New Zealand Clinical Trials Register, ACTRN12614000231640.he prevention of chronic suppurative otitis media in children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα

A study protocol for a cluster randomised trial for the prevention of chronic suppurative otitis media in children in Jumla, Nepal Abstract Background Chronic Suppurative Otitis Media (CSOM) is the commonest cause of preventable deafness, affecting 164 million people worldwide, 90 % of whom live in low resource countries, such as Nepal. Simple, inexpensive treatment of acute otitis media can prevent the development of CSOM and its sequelae: deafness, abscess, encephalitis, and, rarely, death. CSOM is a disease of poverty and its social determinants: low parental education, overcr... περισσότερα »

Garenoxacin (GRNX), levofloxacin (LVFX), ciprofloxacin (CPFX) and sitafloxacin (STFX) against current isolates of P. aeruginosa

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα

Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media Abstract Background The aim of the present study was to evaluate the bactericidal activity of four new fluoroquinolones against current isolates of *Pseudomonas aeruginosa* from the patients with chronic suppurative otitis media (CSOM). Methods We examined bactericidal activity of four types of fluoroquinolones, garenoxacin (GRNX), levofloxacin (LVFX), ciprofloxacin (CPFX) and sitafloxacin (STFX) against current isolates of *P. aeruginosa* (50 st...περισσότερα »

Discriminant validity and test re-test reproducibility of a gait assessment in patients with vestibular dysfunction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα

Discriminant validity and test re-test reproducibility of a gait assessment in patients with vestibular dysfunction Abstract Background Gait function may be impaired in patients with vestibular disorders, making gait assessment in the clinical setting relevant for this patient population. The purpose of this study was to evaluate the discriminant validity of a gait assessment protocol between patients with vestibular disorders and healthy participants. Furthermore, test re-test reproducibility and the measurement error of gait performance measures in patients with vestibular lesi... περισσότερα »

Laryngeal cancer in nondrinker nonsmoker young patients: a distinct pathological entity?.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα

Laryngeal cancer in nondrinker nonsmoker young patients: a distinct pathological entity?. Abstract Purpose of review: Laryngeal cancer published literature was reviewed, with emphasis on reporting on young patients (<40 years). With such information, to comment on the evidence or not, that such patients, should they be nondrinkers and nonsmokers, have a differing cause and genetic/molecular profile rather than a spectrum of the classic disease. Recent findings: Head and neck cancer in young patients is documented at a rate of 0.4-3.6%, with laryngeal cancer being identified in les... περισσότερα »

Rhinology: updates on best practice.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα

Rhinology: updates on best practice

Surgical repair of nasal septal perforations

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα

Surgical repair of nasal septal perforations: an update.: Purpose of review: Nasal septal perforations can have a substantial impact on patient's nasal breathing and subsequent quality of life. Various surgical techniques have previously been described for the repair of these perforations. In this review, we examine the most recent literature evaluating surgical techniques for the repair of nasal septal perforations. Recent findings: Twenty-seven studies evaluating 646 patients were included. None of these studies compared different surgical techniques. Four major categories of surgi... περισσότερα »

Indications for open procedures in the endoscopic era.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα

Indications for open procedures in the endoscopic era.: Purpose of review: Endoscopic sinus surgery became the gold standard in inflammatory disorders of the nose and paranasal sinuses, in cerebrospinal fluid leak and epistaxis management, and established its efficacy in the oncology of the region. However, there are certain limitations which make an external approach mandatory. This article reviews the recent literature describing the cases where an open procedure is still indicated. Recent findings: Despite the evolution of endoscopic surgery external approaches are still indicated...περισσότερα »

New innovations in office-based rhinology.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα

New innovations in office-based rhinology.: Purpose of review: Chronic rhinosinusitis (CRS) affects millions of patients worldwide, with significant health and financial implications. There is an immense utilization of resources involved, including prescription medications and surgical interventions. With increased emphasis on sound resource allocation and patient convenience, recent years have witnessed significant expansion in office-based rhinologic procedures. The purpose of this review is to discuss new technologic innovations designed to facilitate treatment of sinonasal disea... περισσότερα »

Innovations in nasal valve surgery.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα

Innovations in nasal valve surgery.: Purpose of review: This article reviews current practices in nasal valve repair and highlights recent innovations in the medical literature. Recent findings: A surgeon's choice regarding a proper nasal valve repair technique depends heavily on the patient's site of obstruction. While classical maneuvers to improve the internal and external nasal valves have been employed for several decades, increasing understanding of lateral wall insufficiency and its role in nasal valve compromise has led to improvement of proposed methods for correcting the na... περισσότερα »

Olfaction following endoscopic skull base surgery.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα

Olfaction following endoscopic skull base surgery.: Purpose of review: As endoscopic skull base surgery advances and becomes more common, recognizing and understanding all possible risks and complications of these procedures is a significant responsibility of the operating surgeon. Olfaction is a deficit often ignored or trivialized by the treating physician, in spite of its loss causing major impacts on our patients' quality of life. Recent findings: Olfactory dysfunction after endoscopic skull base surgery is still being debated in the literature, with evidence supporting both side... περισσότερα »

Knowing what and where: TMS evidence for the dual neural basis of geographical knowledge

otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 14 δευτερόλεπτα

Publication date: Available online 17 December 2015 Source:Cortex Author(s): Paul Hoffman, Sebastian Crutch All animals acquire knowledge about the topography of their immediate environment through direct exploration. Uniquely, humans also acquire geographical knowledge indirectly through exposure to maps and verbal information, resulting in a rich database of global geographical knowledge. We used transcranial magnetic stimulation […]

Face processing in autism: Reduced integration of cross-feature dynamics

Publication date: Available online 17 December 2015 Source:Cortex Author(s): Punit Shah, Geoffrey Bird, Richard Cook Characteristic problems with social interaction have prompted considerable interest in the face processing of individuals with Autism Spectrum Disorder (ASD). Studies suggest that reduced integration of information from disparate facial regions likely contributes to difficulties recognizing static faces in this […]

Resting-state low-frequency fluctuations reflect individual differences in spoken language learning

Publication date: Available online 17 December 2015 Source:Cortex Author(s): Zhizhou Deng, Bharath Chandrasekaran, Suiping Wang, Patrick C.M. Wong A major challenge in language learning studies is to identify objective, pre-training predictors of success. Variation in the low-frequency fluctuations (LFFs) of spontaneous brain activity measured by resting-state functional magnetic resonance imaging (RS-fMRI) has been found to […]

When the left brain’s away, the right will play Emergent artistic proficiency in primary progressive apraxia of speech

Publication date: Available online 17 December 2015 Source:Cortex Author(s): David Bergeron, Louis Verret, Olivier Potvin, Simon Duchesne, Robert Laforce from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1IXRNG3 via IFTTT

Spontaneous angina bullosa hemorrhagica

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα

Acta Otorrinolaringológica Española Available online 17 December 2015 In Press, Corrected Proof — Note to users Imágenes en otorrinolaringología Dos casos de angina bullosa hemorrágica espontánea Two cases of spontaneous angina bullosa hemorrhagica - Belén Lozano-Masdemont, , - Marta Bergón-Sendín, - Ricardo Suárez-Fernández - Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España [image: Image for figure Figura 1] [image: Image for figure Figura 2]

Maxillary sinus hemangioma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα

Case report Maxillary sinus hemangioma: usefulness of embolization according to classification Hemangioma de seio maxilar: utilidade da embolização de acordo com a classificação - Hisashi Hasegawaa, - Hiroumi Matuzakia, , , - Tohru Furusakaa, - Takeshi Oshimaa, - Shinobu Masudab, - Toshiyuki Unnoc, - Osamu Abec - a Department of Otorhinolaryngology, Head and Neck Surgery, Nihon University School of Medicine, Japan - b Department of Pathology, Nihon University School of Medicine, Japan - c Department of Radiology, Nihon University School of Medic... περισσότερα »

[Development of Researches on the Underlying Mechanism of Acupuncture Stimulation of Baliao-points for Improving Outlet Obstruction Constipation].

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

*[Development of Researches on the Underlying Mechanism of Acupuncture Stimulation of Baliao-points for Improving Outlet Obstruction Constipation].* Zhen Ci Yan Jiu. 2015 Oct;40(5):427-30 Authors: Zou YY, Ding SQ, Zhou HF, Ye JJ, Xu XZ, Hu GY, Zhang JB Abstract Outlet obstruction constipation (OOC) is a common clinical problem affecting many people's daily life quality nowadays. Acupuncture therapy is effective in easing OOC to reduce patients' sufferings by stimulation of Baliao-points i. e., bilateral Shangliao (BL 31), Ciliao (BL 32), Zhongliao (BL 33) and Xialiao (BL 34), wh... περισσότερα »

[Analysis on Current State of Acupuncture Clinical Trials with Sham Acupuncture Design in Wes- tern Countries].

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

*[Analysis on Current State of Acupuncture Clinical Trials with Sham Acupuncture Design in Wes- tern Countries].* Zhen Ci Yan Jiu. 2015 Oct;40(5):423-6 Authors: He W, Tong YY, Zhao YK, Li YW, Zhang L, Liu ZH Abstract The design of "sham acupuncture" is necessary in clinical trials of acupuncture for confirming its effectiveness in the treatment of different disorders. The authors of the present paper made a comprehensive analysis on "sham acupuncture"or "placebo acupuncture" in clinical trials of acupuncture therapy in western countries from 1) the definition and background of s...περισσότερα »

["Santong Needling" by Stages for Moderate and Severe Peripheral Facial Paralysis in the Acute Period].

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

*["Santong Needling" by Stages for Moderate and Severe Peripheral Facial Paralysis in the Acute Period].* Zhen Ci Yan Jiu. 2015 Oct;40(5):419-22, 426 Authors: Zhang HT, Qiu LL Abstract OBJECTIVE: To observe clinical effects of "Santong needling" by stages for patients with moderate and severe peripheral facial paralysis (PFP) in the acute period. METHODS: Sixty patients with moderate and severe PFP were equally and randomly divided into Santong needling group and control group. The patients of the Santong needling group were treated by shallow puncture of Yifeng (TE 17, on the a...περισσότερα »

[Clinical Trial of Treatment of Cervicogenic Scapulohumeral Periarthritis by Red-hot Needle Therapy Combined with Cupping].

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

*[Clinical Trial of Treatment of Cervicogenic Scapulohumeral Periarthritis by Red-hot Needle Therapy Combined with Cupping].* Zhen Ci Yan Jiu. 2015 Oct;40(5):415-8 Authors: Yuan T, Wang F Abstract OBJECTIVE: To observe the therapeutic effect of red-hot needle therapy combined with cupping for cervicogenic periarthritis of shoulder. METHODS: Forty-two cases of cervicogenic periarthritis of shoulder were randomized into red-hot needle group and routine acupuncture group (n = 21). For patients of the routine acupuncture group, the filiform needles were applied to Tianzhu (BL 10), Ji...περισσότερα »

[Randomized Controlled Clinical Trial for Analyzing Effect of "Spleen-Stomach Regulation Nee- dling" on Oxidative Stress Level in Patients with Diabetic Nephropathy].

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

*[Randomized Controlled Clinical Trial for Analyzing Effect of "Spleen-Stomach Regulation Nee- dling" on Oxidative Stress Level in Patients with Diabetic Nephropathy].* Zhen Ci Yan Jiu. 2015 Oct;40(5):409-14 Authors: Wang M, Zhang ZL, Ji XQ, Yang YQ, Yang XJ, Li S Abstract OBJECTIVE: To observe the effect of "spleen-stomach needling" on changes of plasma malondialdehyde. (MDA), protein carbonyl (PCO, an oxidative stress damage biomaker), 8-hydroxyguanine (8-OHdG, an indicator of oxidative DNA damage) and the activity of superoxide dismutase (SOD) levels in patients with diabetic...περισσότερα »

[Effect of Electroacupuncture Stimulation of Acupoints at the Distal Limbs on Heart Function of Volunteers with Acute Hypoxia].

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

*[Effect of Electroacupuncture Stimulation of Acupoints at the Distal Limbs on Heart Function of Volunteers with Acute Hypoxia].* Zhen Ci Yan Jiu. 2015 Oct;40(5):402-8 Authors: Dong YQ, Xiu CY, Sa ZY, Xu JS Abstract OBJECTIVE: To observe the effect of electroacupuncture (EA) stimulation of different acupoints at the distal ends of the limbs on cardiac function in volunteers with acute hypoxia, so as to determine if its actions are realized by way of segmental innervations or meridians. METHODS: Twenty healthy volunteers were divided into control, Quze (PC 3), Shousanli (LI 10), G...περισσότερα »

[Effect of Acupuncture and Moxibustion Intervention on Contents of Serum Interleukin-7 and In- terleukin-18 in Cyclophosphamide-induced Immune Suppression in Tumor-bearing Mice].

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

*[Effect of Acupuncture and Moxibustion Intervention on Contents of Serum Interleukin-7 and In- terleukin-18 in Cyclophosphamide-induced Immune Suppression in Tumor-bearing Mice].* Zhen Ci Yan Jiu. 2015 Oct;40(5):396-401 Authors: Lu M, Zhang JJ, Cao DM, Zhao XX, Wang GA, Zhang L Abstract OBJECTIVE: To observe the effect of acupuncture and moxibustion intervention on the contents of serum IL-7 and IL-18 and white blood cell counts in cyclophosphamide (CTX)-induced hypofunction of immunity in tumor-bearing mice, so as to explore its mechanism underlying improvement of immune suppr... περισσότερα »

[Effect of Preconditioning of Catgut Implantation at Acupoints on Changes of Behavior and EEG in Epileptic Rats].

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

*[Effect of Preconditioning of Catgut Implantation at Acupoints on Changes of Behavior and EEG in Epileptic Rats].* Zhen Ci Yan Jiu. 2015 Oct;40(5):392-5 Authors: Jin Z, Yong RL, Wang CY, Wang YL, Wang LJ, Chen J Abstract OBJECTIVE: To observe the effect of preconditioning of catgut implantation on changes of behavior and EEG of rats with epilepsy. METHODS: Forty male Wistar rats were randomly divided into control, model, catgut implantation, medication groups (10 rats/group). The catgut implantation was performed at "Yintang" (EX 2) to "Baihui" (GV 20) and "Changqiang" (GV 1) on...περισσότερα »

[Effects of Suspending Moxibustion at "Dazhui" (GV 14) on Neurogenic Inflammation in Asthma Rats].

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

*[Effects of Suspending Moxibustion at "Dazhui" (GV 14) on Neurogenic Inflammation in Asthma Rats].* Zhen Ci Yan Jiu. 2015 Oct;40(5):388-91 Authors: Zhang W, Jiao L, Xiong J Abstract OBJECTIVE: To observe the effect of suspending-moxibustion stimulation of "Dazhui" (GV 14) with different quantities on the levels of nerve growth factor(NGF) , substance P(SP) , calcitonin gene-related peptide (CGRP), neurokinin A (NKA) , neurokinin B (NKB) and phosphorylated extracellular signal-regulated kinases (pERK) in the bronchoalveolar lavage fluid (BALF) of asthma rats, so as to analyze it...περισσότερα »

[Effect of Electroacupuncture Intervention at Different Time-points on Levels of HSP 70, MDA, SOD and GSH-PX of Liver in Rats with Simulated Weightlessness].

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

*[Effect of Electroacupuncture Intervention at Different Time-points on Levels of HSP 70, MDA, SOD and GSH-PX of Liver in Rats with Simulated Weightlessness].* Zhen Ci Yan Jiu. 2015 Oct;40(5):383-7 Authors: Song Y, Zhao GZ, Zhao BX, Ji B, Wang DS, Zhang H, Mao YQ, Zhang P, Xu YS, Liu YL, Lu YW, Dai J, Li YH Abstract OBJECTIVE: To observe the effect of acupuncture intervention at different time-points on the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), the content of malonaldehyde (MDA) and expression of heat shock protein 70 (HSP 70) of liver tissue i...περισσότερα »

[Effects of Electroacupuncture Stimulation of "Neiguan" (PC 6) at Different Frequencies on Plasma Vasoactive Substance Levels in Myocardial Ischemic Reperfusion Rats].

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

*[Effects of Electroacupuncture Stimulation of "Neiguan" (PC 6) at Different Frequencies on Plasma Vasoactive Substance Levels in Myocardial Ischemic Reperfusion Rats].* Zhen Ci Yan Jiu. 2015 Oct;40(5):378-82 Authors: Wang SK, Lu C, Wang YJ Abstract OBJECTIVE: To observe the effect of electroacupuncture (EA) stimulation of "Neiguan" (PC 6) at different frequencies on plasma vasoactive substance levels in myocardial ischemia-reperfusion (MIR) injury rats, so as to explore its mechanisms underlying improvement of acute myocardial ischemia. METHODS: A total of 40 Wistar rats were ra...περισσότερα »

[Effect of Electroacupuncture Stimulation of Different Tissues at "Huantiao" (GB 30) Acupoint on Expression of Phosphorylated JNK and c-jun in Spinal Cord of Rats with Sciatic Nerve Injury].

Alexandros G. SfakianakisστοPubMed ORL Articles by Alexandros G.SfakianakisΠριν από 16 δευτερόλεπτα

*[Effect of Electroacupuncture Stimulation of Different Tissues at "Huantiao" (GB 30) Acupoint on Expression of Phosphorylated JNK and c-jun in Spinal Cord of Rats with Sciatic Nerve Injury].* Zhen Ci Yan Jiu. 2015 Oct;40(5):373-7 Authors: Liu XT, Tao X, Ma TM, Ma XD, Yan HC, Tian L, Liu PP Abstract OBJECTIVE: To observe the effects of electroacupuncture (EA) stimulation of different tissues (nerve stem, muscular layer) at "Huantiao" (GB 30) acupoint on expression of hosphorylated c-jun N-terminal kinase (p-JNK) and c-jun (p-c-jun) proteins in the lumbar spinal cord in rats with ... περισσότερα »

Laronidase treatment in otolaryngological manifestations of patients with mucopolysaccharidosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

The impact of via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 17 December 2015 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Ana Paula Fiuza Funicello Dualibi, Ana Maria Martins, Gustavo Antônio Moreira, Marisa Frasson de Azevedo, Reginaldo Raimundo Fujita, Shirley Shizue Nagata Pignatari IntroductionMucopolysaccharidosis (MPS) is a lysosomal storage disease caused by deficiency of α-l-iduronidase. The otolaryngological findings include hearing loss, otorrhea, recurrent otitis, hypertrophy of tonsils and adenoid...περισσότερα »

Imbalance in the diurnal salivary testosterone/cortisol ratio in men with severe obstructive sleep apnea

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

: an observational study via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 17 December 2015 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Cristina Mihaela Ghiciuc, Lucia Corina Dima-Cozma, Raluca Mihaela Bercea, Catalina Elena Lupusoru, Traian Mihaescu, Sebastian Cozma, Francesca Romana Patacchioli IntroductionThe complex relationship between sleep disorders and hormones could lead to alterations in the production of cortisol and testosterone in obstructive sleep apnea (OSA) patients.ObjectiveThe purpose of this stu...περισσότερα »

Bilateral congenital middle ear cholesteatoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα

One case of bilateral congenital middle ear cholesteatoma via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 17 December 2015 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Mihael Ries, Mirjana Kostić, Jakov Ajduk, Robert Trotić, Vladimir Bedeković [image: Coronal MDCT scan of the left temporal bone showing aerated mesotympanum and the ...] [image: Axial MDCT scan of the left temporal bone at the level of the horizontal portion ...] [image: Sagittal MDCT scan of the left temporal bone at the level of malleus handle, ...περισσότερα »

Polymorphisms in methylenetetrahydrofolate reductase and cystathionine beta-synthase in oral cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα

– a case–control study in southeastern Brazilians via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 17 December 2015 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Andressa Barbosa, Marcelo dos Santos, José Roberto Vasconcelos de Podestá, Sônia Alves Gouvêa, Sandra Ventorin Von Zeidler, Iúri Drumond Louro, Melissa de Freitas Cordeiro Silva IntroductionOral squamous cell carcinoma (OSCC) is a serious public health problem, due to its high mortality rate and worldwide rising incidence. OSCC susceptibility is mediated ...περισσότερα »

Predictive factors of occult neck metastasis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

in patients with oral squamous cell carcinoma via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 17 December 2015 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Renato Fortes Bittar, Homero Penha Ferraro, Marcelo Haddad Ribas, Carlos Neutzling Lehn IntroductionIt is well established that cervical lymph node metastasis is the most important prognostic factor in patients with oral squamous cell carcinoma of the upper aerodigestive tract. The definition of parameters and classifications that could separate patients in g... περισσότερα »

Acoustic analysis of oropharyngeal swallowing using Sonar Doppler

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

Acoustic analysis of oropharyngeal swallowing using Sonar Doppler via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 17 December 2015 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Franciele Savaris Soria, Roberta Gonçalves da Silva, Ana Maria Furkim IntroductionDuring the aging process, one of the functions that changes is swallowing. These alterations in oropharyngeal swallowing may be diagnosed by methods that allow both the diagnosis and biofeedback monitoring by the patient. One of the methods recently described ...περισσότερα »

Paragangliomas

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα

Introduction Publication date: Available online 17 December 2015 *Source:*Operative Techniques in Otolaryngology-Head and Neck Surgery Author(s): David Myssiorek Radiotherapy for Head and Neck Paragangliomas Publication date: Available online 17 December 2015 *Source:*Operative Techniques in Otolaryngology-Head and Neck Surgery Author(s): William M. Mendenhall, Robert J. Amdur Treatment options for benign paragangliomas (PG) include surgery, radiotherapy (RT), stereotactic radiosurgery (SRS), and observation. Patients who are elderly, infirm, and have a limited life expectancy m...περισσότερα »

Surgical Management of Vagal Paraganglioma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα

Surgical Management of Vagal Paraganglioma via Otolaryngology-Head and Neck Surgery Publication date: Available online 17 December 2015 *Source:*Operative Techniques in Otolaryngology-Head and Neck Surgery Author(s): Mumtaz J. Khan, David Goldenberg, David Myssiorek Vagal paragangliomas are nonchromaffin tumors that originate from paraganglionic chemoreceptor cell bodies associated with the Vagus Nerve. Although both, surgical excision and radiation therapy have been reported to be effective treatment modalities, the effectiveness of one over the other remains unclear. There are several... περισσότερα »

Treatment of Laryngeal Paraganglioma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα

Treatment of Laryngeal Paraganglioma via Otolaryngology-Head and Neck Surgery Publication date: Available online 17 December 2015 *Source:*Operative Techniques in Otolaryngology-Head and Neck Surgery Author(s): David Myssiorek Laryngeal paragangliomas are rare tumors that arise from three superior and one inferior paraganglia within the larynx. They present as painless, submucosal masses that become symptomatic after they surpass a critical size. At this point, hoarseness followed by dysphagia will become evident. These tumors are rarely familial and rarely, if at all, malignant.Diagnos... περισσότερα »

Management of the Carotid Arteries During Head and Neck Paraganglioma Surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα

Management of the Carotid Arteries During Head and Neck Paraganglioma Surgery via Otolaryngology-Head and Neck Surgery Publication date: Available online 17 December 2015 *Source:*Operative Techniques in Otolaryngology-Head and Neck Surgery Author(s): Gregory G. Westin, Mark A. Adelman, Frank J. Veith BackgroundSurgery for head and neck paraganglioma presents a high risk for carotid artery injury.Objective: To describe a strategy for pre-operative evaluation, risk stratification, and operative management of the carotid arteries when operating on head and neck paraganglioma.FindingsWe st... περισσότερα »

Jugular Paragangliomas

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα

– Resection Techniques via Otolaryngology-Head and Neck Surgery Publication date: Available online 17 December 2015 *Source:*Operative Techniques in Otolaryngology-Head and Neck Surgery Author(s): Michael Gleeson The prerequisites for surgical resection of tumours arising in the jugular foramen are adequate access, control of the major vessels and the ability to move the facial nerve safely out of the operative field if necessary. Without it the surgeon risks catastrophic haemorrhage, cranial nerve palsies that might have been avoided and insufficient access to remove the whole tumour... περισσότερα »

Radiotherapy for Head and Neck Paragangliomas

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα

Radiotherapy for Head and Neck Paragangliomas via Otolaryngology-Head and Neck Surgery Publication date: Available online 17 December 2015 *Source:*Operative Techniques in Otolaryngology-Head and Neck Surgery Author(s): William M. Mendenhall, Robert J. Amdur Treatment options for benign paragangliomas (PG) include surgery, radiotherapy (RT), stereotactic radiosurgery (SRS), and observation. Patients who are elderly, infirm, and have a limited life expectancy may be followed. This is also a reasonable option for younger, healthier patients who have no evidence of progression on serial co...περισσότερα »

Osteoclastoma of Hyoid Bone

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα

Huge Osteoclastoma of Hyoid Bone: A Case Report: AbstractGiant cell tumors (GCT) of hyoid bone are very rare, and only few individual cases were reported in literature. We present such a case of GCT arising from left cornu of hyoid bone. The patient underwent trans-cervical complete excision of the tumour. Postoperatively, patient did well without recurrence or metastasis for 2 years follow up.

Implanted Autologous Auricular Cartilage

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα

Study of Outcome of an Implanted Autologous Auricular Cartilage: A Preliminary Experimental Research in Rabbits: AbstractTo investigate the viability of the implanted crushed and uncrushed auricular cartilage graft with intact perichondrium with respect to macroscopic and microscopic parameters. Cartilage grafts from 8 white New Zealand rabbits were harvested from the right auricle, with intact perichondrial layers. There were two categories Pre implant and Post-implant and two types, mildly crushed and uncrushed cartilage graft. The cartilage grafts were implanted into the subcuta... περισσότερα »

Lipoma of Hard Palate

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα

Lipoma of Hard Palate: Commonest Tumour at Rarest Site: AbstractLipoma is the most common benign soft tissue tumor. Lipomas are relatively uncommon tumours in the oral cavity accounting only 1–4 %. Half of oral lipomas are in the cheek and the remaining is found in the tongue, floor of the mouth, lips, palate, and gingival mucosa. We are reporting a case of lipoma that occurred in the hard palate, which is extremely rare.

Edoxaban in patients with atrial fibrillation

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 24 δευτερόλεπτα

Percutaneous coronary interventions and antiplatelet therapy in renal transplant recipients

Cardiovascular disease is the leading cause of mortality and morbidity following renal transplantation (RT), accounting for 40–50% of all deaths. After renal transplantation, an adverse cardiovascular event occurs in nearly 40% of patients; given the dialysis vintage and the average wait time, the likelihood of receiving coronary revascularization is very high. There is a significant […]

Assessment of blood pressure in patients with hypertension aged 60-79 years before and after the publication of the 2014 Eighth Joint National Committee report

Objectives: In late 2013, the Joint National Committee (JNC 8) published hypertension treatment recommendations endorsing a goal blood pressure (BP) of < 150/90 mmHg starting at age 60 years. This was in contrast to other cardiovascular groups recommending age 80 years for this BP goal. This study examined mean BP in patients from age 60 […]

Early postdisaster health outreach to modern families: a cross-sectional study

Objectives This study investigated whether the early outreach programme following the Utøya massacre reached out to the parents of the young survivors. Additionally, we explored whether specialised mental healthcare services were provided to parents presenting elevated levels of PTSD and depression reactions. Design Cross-sectional survey, face-to-face interviews and questionnaires. Setting Norway, aftermath of the Utøya […]

Cirrhosis

Cirrhosis: Liver disease characterized by irreversible scarring. Alcohol and viral hepatitis, including both hepatitis B and hepatitis C, are among the many causes of cirrhosis. Cirrhosis can cause yellowing of the skin (jaundice), itching, and fatigue. Diagnosis is suggested by physical examination and blood tests, and it can be confirmed by liver biopsy. Complications of […]

A review of the cutaneous manifestations of Helicobacter cinaedi

Abstract Helicobacter cinaedi (H. cinaedi) is an emerging Gram-negative spiral bacillus that was first reported in 1984. It has been implicated as a cause of gastroenteritis and bacteremia in immunocompromised individuals. H. cinaedi-associated bacteremia sometimes is accompanied by skin lesions; however, the cutaneous manifestations of this pathogen are not widely known. To our knowledge, a […]

Perseverative Error Subtypes in Patients with Alzheimer’s Disease and Mild Cognitive Impairment

The post Perseverative Error Subtypes in Patients with Alzheimer’s Disease and Mild Cognitive Impairment appeared first on Welcome to Avens. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Oc8obt via IFTTT

Thyroid cancer in 2015: Molecular landscape of thyroid cancer continues to be … – Nature.com

Nature.com Thyroid cancer in 2015: Molecular landscape of thyroid cancer continues to be … Nature.com Studies published in 2015 have continued to unravel the genomic landscape of thyroid cancer, particularly of its less common forms (such as medullary and anaplastic carcinomas) and of familial forms of thyroid cancer. As a result, new diagnostic and … […]

Relationship Between Biophysical Parameters and Synthetic Indices Derived from Hyperspectral Field Data in a Salt Marsh from Buenos Aires Province, Argentina

Abstract Remote sensing tools allow the environmental evaluation of coastal wetlands at a landscape scale, but a deeper understanding is needed of the interactions between biophysical parameters and the electromagnetic signal. The goal of this work was to analyze and quantify the influence of the aboveground biomass and the Leaf Area Index (LAI) on the […]

Columnist’s cancer treatment: Crossing a bright, glowing line – Glenwood Springs Post Independent

Glenwood Springs Post Independent Columnist’s cancer treatment: Crossing a bright, glowing line Glenwood Springs Post Independent With the RN and physicist standing by, a nuclear tech read me a list of risks and possibilities such as colon cancer, damage to salivary glands and taste, etc. I was told to keep my hospital bracelet on for […]

Mast Cell Deficiency Limits the Development of Chronic Rhinosinusitis in Mice

Background: Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in adults in both developing and developed countries. The etiology and pathogenesis of CRS remain poorly understood, and the disease is refractory to therapy in many patients. Mast cell activation has been demonstrated in the sinonasal mucosa of patients with CRS; however, the […]

Emotional Perception of Music in Children With Bimodal Fitting and Unilateral Cochlear Implant

Objective: Biological, structural, and acoustical constraints faced by cochlear implant (CI) users can alter the perception of music. Bimodal fitting not only provides bilateral hearing but can also improve auditory skills. This study was conducted to assess the impact of this amplification style on the emotional perception of music among children with hearing loss (HL). […]

Efficacy evaluation of clonazepam for symptom remission in burning mouth syndrome: a meta-analysis

Psychological disorders and oral lichen planus: matched case-control study and literature review

Abstract Objective Oral lichen planus (OLP) may be linked to psychological disorders. This study investigated psychological factors associated with OLP. Methods A case-control study with incident OLP case patients and age-gender-socioeconomic status-matched controls, recruited from among relatives, accompanying persons, and departmental staff, investigated psychological traits using the Psychological General Well-Being Index-Short form. Common factor analysis […]

Recurrent upper respiratory tract infections (URTI) : Preventive Audiology: Screening for Hearing Impairment in Children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα

Preventive Audiology: Screening for Hearing Impairment in Children Having Recurrent URTI: AbstractA late detection of hearing impairment in children can affect speech and language development. Otitis media with effusion (OME) associated with risk factors like recurrent upper respiratory tract infections (URTI) is considered the most common cause of silent hearing impairment among children. So this study was carried out to screen such at risk children for hearing impairment. The study was conducted on 1000 children in the age group of 2–12 years who presented to the OPD of ENT and ...περισσότερα »

Preventive Audiology: Screening for Hearing Impairment in Children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα

Audiological Profile in Primary Sjögren’s Syndrome

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα

Audiological Profile in Primary Sjögren’s Syndrome in a Tertiary Care Setting and its Clinical Implications: AbstractThis study aims to assess the frequency and the profile of hearing loss among patients with primary Sjögren’s syndrome in a tertiary care hospital in India and to look for an association between hearing loss and immunological parameters (anti-SSA antibody, anti-SSB antibody, anticardiolipin antibodies, complements C3 and C4). This prospective observational study was done from January 2011 to October 2011 on consecutive patients diagnosed with primary Sjögren’s syndro... περισσότερα »

Prosthetic-Joint-Associated Bordetella holmesii Infection

sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα

Bordetella holmesii is a globally distributed pathogen that is increasingly recognized as a cause of both pertussis-like respiratory infections and invasive disease. In this study, we describe a case of an immunocompetent man who developed B holmesii infection of his femoral prosthesis—the fifth B holmesii orthopedic infection reported in literature to date. This article highlights […]

Economic Impact of Meningococcal Outbreaks in Brazil and Colombia

Background. The impact of meningitis outbreaks is substantial. We aim to calculate the costs of meningococcal outbreaks in Brazil and Colombia from the healthcare system perspective. Methods. A review of the literature was performed on costs associated with meningococcal outbreak in Latin America. Structured interviews capturing information about the use of resources, expenses allocated to […]

Cure Tinnitus By Meditating

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 26 δευτερόλεπτα

Cure Tinnitus By Meditating: If you suffer from tinnitus, you may go to great lengths to find a cure. Many people will unfortunately try everything from ear drops to surgery in an effort to ease the symptoms. Tinnitus may be characterized by a ringing, hissing, tingling or other sound in the ears, and it may be loud, soft, constant or intermittent. In many cases, the sound is most noticeable when there is minimal background noise, such as when you are trying to fall asleep, reading a book or working in a quiet office. This is a condition that can have a truly negative impact on your... περισσότερα »

Edoxaban in patients with atrial fibrillation

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 26 δευτερόλεπτα

Edoxaban, a direct factor Xa inhibitor, was extensively studied in the prevention and treatment of venous thromboembolism and in patients with nonvalvular atrial fibrillation (AF). The aim of this review is to focus specifically on the efficacy and safety profile of edoxaban in patients with AF from preclinical development through the phase III trial that led to regulatory approval. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1YlDqm2 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Qtp... περισσότερα »

Clinical Trial Registration: The Time Has Come…

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα

Registration of a clinical trial requires that researchers document key aspects of their research methodology in a publically available database. In the words of the International Committee of Medical Journal Editors, the registration of clinical trials is needed "to prevent selective publication and selective reporting of research outcomes, to prevent unnecessary duplication of research efforts, to help patients and the public know what trials are planned or ongoing into which they might want to enroll, and to help give ethics review boards considering approval of new studies a vi... περισσότερα »

Should This Patient With Ischemic Stroke Receive Fluoxetine?

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα

You admit T.R., a 75-year-old man, to your inpatient rehabilitation unit 10 days after a stroke. He has a medical history of hypertension and type II diabetes. On the day of his admission to the neurology service, he experienced a sudden onset of severe left-sided weakness with a facial droop and slurring of speech. His husband was driving them both to a social event at the time and detoured immediately to the emergency department, where the patient received tissue plasminogen activator (tPA) for a large, right middle cerebral artery thrombosis seen on magnetic resonance imaging. ... περισσότερα »

Histopathologic and Clinical Characterization of Thyroid Tumors Carrying the BRAFK601E Mutation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα

Histopathologic and Clinical Characterization of Thyroid Tumors Carrying the BRAFK601E Mutation: Thyroid , Vol. 0, No. 0. Author information Michelle Afkhami,*† Arivarasan Karunamurthy,† Simion Chiosea, Marina N. Nikiforova, Raja Seethala,Yuri E. Nikiforov, and Christopher Coyne Department of Medicine, Division of Endocrinology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. *Present Address: Department of Pathology, Division of Clinical Molecular Diagnostic, City of Hope National Medical Center, Duarte, California. †These authors contributed equally to this work... περισσότερα »

2015 American Thyroid Association Guidelines for Thyroid Nodules and Differentiated Thyroid Cancer and Their Implementation in Various Care Settings

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα

2015 American Thyroid Association Guidelines for Thyroid Nodules and Differentiated Thyroid Cancer and Their Implementation in Various Care Settings: Thyroid , Vol. 0, No. 0. Author information Fabián Pitoia1 and Akira Miyauchi2 1Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina. 2Department of Surgery, Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan. Address correspondence to: *Fabián Pitoia, MD* *Division of Endocrinology* *Hospital de Clínicas* *Av. Cordoba 2351* *Buenos Aires 1001* Argentina *E-mail:* fpitoia... περισσότερα »

A case for the use of receiver operating characteristic analysis of potential clinical efficacy biomarkers in advanced renal cell carcinoma

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 28 δευτερόλεπτα

Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader http://ift.tt/1mr3xH5 via IFTTT

Effects of High Doses of Vitamin C on Cancer Patients in Singapore: Nine Cases

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 28 δευτερόλεπτα

*Introduction*. Intravenous high-dose vitamin C therapy is widely used in naturopathic and integrative oncology; however, a study reviewing its effects has never been performed in Singapore. This article serves to document administration of supportive vitamin C therapy for cancer patients in Singapore. *Methods.* The clinical response of 9 cancer patients of differing stages to the regular administration of large doses (25-100 g/d) of intravenous vitamin C (IVC; ascorbic acid) is outlined. Tumor pathology and patient health were verified by doctors who do not practice vitamin C tr... περισσότερα »

Suppression of vascular network formation by chronic hypoxia and prolyl-hydroxylase 2 (phd2) deficiency during vertebrate development

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 28 δευτερόλεπτα

Abstract In the adult, new vessels and red blood cells form in response to hypoxia. Here, the oxygen-sensing system (PHD–HIF) has recently been put into focus, since the prolyl-hydroxylase domain proteins (PHD) and hypoxia-inducible factors (HIF) are considered as potential therapeutic targets to treat ischemia, cancers or age-related macula degeneration. While the oxygen-sensing system (PHD–HIF) has been studied intensively in this respect, only little is known from developing vertebrate embryos since mutations within this pathway led to an early decease of embryos due to placent...περισσότερα »

Ectopic Subcutaneous Implantation of Thyroid Tissue After Gasless Transaxillary Robotic Thyroidectomy for Papillary Thyroid Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα

Ectopic Subcutaneous Implantation of Thyroid Tissue After Gasless Transaxillary Robotic Thyroidectomy for Papillary Thyroid Cancer: Thyroid Dec 2015, Vol. 25, No. 12: 1381-1382. Author information Stéphanie Espiard,1 Gregory Petyt,2 Georges Lion,2 Amandine Béron,2 Christine Do Cao,1 Jean-Louis Wémeau,1 Marie-Christine Vantyghem,1 Francois Pattou,3 and Robert Caiazzo3 1Department of Endocrinology and Metabolism, Centre Hospitalier Regional Universitaire de Lille, Lille, France. 2Department of Nuclear Medicine, Centre Hospitalier Regional Universitaire de Lille, Lille, France. 3Depa... περισσότερα »

Emotional Perception of Music in Children With Bimodal Fitting and Unilateral Cochlear Implant

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα

Emotional Perception of Music in Children With Bimodal Fitting and Unilateral Cochlear Implant: Objective: Biological, structural, and acoustical constraints faced by cochlear implant (CI) users can alter the perception of music. Bimodal fitting not only provides bilateral hearing but can also improve auditory skills. This study was conducted to assess the impact of this amplification style on the emotional perception of music among children with hearing loss (HL). Methods: Twenty-five children with congenital severe to profound HL and unilateral CIs, 20 children with bimodal fitti... περισσότερα »

Targeted next-generation sequencing panel (GlioSeq) provides comprehensive genetic profiling of central nervous system tumors

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 29 δευτερόλεπτα

Background Identification of genetic changes in CNS tumors is important for the appropriate clinical management of patients. Our objective was to develop a next-generation sequencing (NGS) assay for simultaneously detecting the various types of genetic alterations characteristic for adult and pediatric CNS tumors that can be applied to small brain biopsies. Methods We report an amplification-based targeted NGS assay (GlioSeq) that analyzes 30 genes for single nucleotide variants (SNVs) and indels, 24 genes for copy number variations (CNVs), and 14 types of structural alterations...περισσότερα »

Isorhapontigenin suppresses growth of patient-derived glioblastoma spheres through regulating miR-145/SOX2/cyclin D1 axis

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 29 δευτερόλεπτα

Background Glioblastoma (GBM) is the most common malignant brain tumor, and glioma stem cells (GSCs) are considered a major source of treatment resistance for glioblastoma. Identifying new compounds that inhibit the growth of GSCs and understanding their underlying molecular mechanisms are therefore important for developing novel therapy for GBM. Methods We investigated the potential inhibitory effect of isorhapontigenin (ISO), an anticancer compound identified in our recent investigations, on anchorage-independent growth of patient-derived glioblastoma spheres (PDGS) and its m...περισσότερα »

Marizomib activity as a single agent in malignant gliomas: ability to cross the blood-brain barrier

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 29 δευτερόλεπτα

Background The proteasome plays a vital role in the physiology of glioblastoma (GBM), and proteasome inhibition can be used as a strategy for treating GBM. Marizomib is a second-generation, irreversible proteasome inhibitor with a more lipophilic structure that suggests the potential for penetrating the blood-brain barrier. While bortezomib and carfilzomib, the 2 proteasome inhibitors approved for treatment of multiple myeloma, have little activity against malignant gliomas in vivo, marizomib could be a novel therapeutic strategy for primary brain tumors. Methods The in-vitro a... περισσότερα »

Perceptions, Attributions, and Emotions Toward Endocrine Therapy in Young Women with Breast Cancer

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 29 δευτερόλεπτα

Journal of Adolescent and Young Adult Oncology , Vol. 0, No. 0. from Cancer via ola Kala on Inoreader http://ift.tt/1mr5TWq via IFTTT

Retention in Care and Patient-Reported Reasons for Undocumented Transfer or Stopping Care among HIV-infected Patients on Antiretroviral Therapy in Eastern Africa: Application of a Sampling-Based Approach

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 29 δευτερόλεπτα

Retention after starting ART is best understood by examining multiple outcomes including stopping care, deaths in care, deaths out of care and silent transfers. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1OaYzEr via IFTTT

Dilemmas in managing pregnant women with Ebola: 2 case reports

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 29 δευτερόλεπτα

We report two cases of Ebola Viral Disease (EVD) in pregnant women. Both women were in the second trimester and survived. The foetus was initially alive. After respectively 31-32 days post negativation maternal blood EVD-PCR, both patients delivered a stillborn foetus with persistent PCR positivity of the amniotic fluid. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1OaYBMw via IFTTT

Mast Cell Deficiency Limits the Development of Chronic Rhinosinusitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα

Mast Cell Deficiency Limits the Development of Chronic Rhinosinusitis in Mice: Background: Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in adults in both developing and developed countries. The etiology and pathogenesis of CRS remain poorly understood, and the disease is refractory to therapy in many patients. Mast cell activation has been demonstrated in the sinonasal mucosa of patients with CRS; however, the specific contribution of mast cells to the development and pathogenesis of this disease has not been established. Objective: The objective of this...περισσότερα »

Sine-wave and noise-vocoded sine-wave speech in a tone language

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα

Sine-wave and noise-vocoded sine-wave speech in a tone language: Acoustic details matter: Sine-wave speech (SWS) is a highly simplified version of speech consisting only of frequency- and amplitude-modulated sinusoids representing the formants. That listeners can successfully understand SWS has led to claims that speech perception must be based on abstract properties of the stimuli far removed from their specific acoustic form. Here it is shown, in bilingual Cantonese/English listeners, that performance with Cantonese SWS is improved by noise vocoding, with no effect on English SWS... περισσότερα »

Niclosamide induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes

Alexandros G. SfakianakisστοΘεραπείαΠριν από 29 δευτερόλεπτα

Publication date: February 2016 *Source:*International Immunopharmacology, Volume 31 Author(s): Mingcheng Huang, Shan Zeng, Qian Qiu, Youjun Xiao, Maohua Shi, Yaoyao Zou, Xiuyan Yang, Hanshi Xu, Liuqin Liang To explore the effects of niclosamide on the viability and apoptosis of rheumatoid arthritis of fibroblast-like synoviocytes (rheumatoid arthritis (RA)fibroblast-like synoviocytes (FLS)), FLS obtained from RA patients were treated with niclosamide. Niclosamide significantly inhibited the viability of RA FLS in a concentration-dependent manner. Niclosamide treated FLS showed a si...περισσότερα »

Inductive immune responses in the Japanese pufferfish (Takifugu rubripes) treated with recombinant IFN-γ, IFN-γrel, IL-4/13A and IL-4/13B

Alexandros G. SfakianakisστοΘεραπείαΠριν από 29 δευτερόλεπτα

Publication date: February 2016 *Source:*International Immunopharmacology, Volume 31 Author(s): Gouranga Biswas, Ryusuke Nagamine, Jun-ichi Hikima, Masahiro Sakai, Tomoya Kono Immune regulation in response to recombinant cytokines (Th1- and Th2-types) is poorly understood in fish. Therefore, we synthesized and purified the Japanese pufferfish, (Takifugu rubripes) recombinant cytokines, namely interferon-gamma (IFN-γ), IFN-γrel, interleukin (IL)-4/13A and IL-4/13B, and then administered by injection to examine the immune regulatory effects on phagocytic activity, superoxide anion pro...περισσότερα »

Levamisole promotes murine bone marrow derived dendritic cell activation and drives Th1 immune response in vitro and in vivo

Alexandros G. SfakianakisστοΘεραπείαΠριν από 29 δευτερόλεπτα

Publication date: February 2016 *Source:*International Immunopharmacology, Volume 31 Author(s): Yubing Fu, Ting Wang, Lei Xiu, Xiaojie Shi, Ziyao Bian, Yongli Zhang, A. Ruhan, Xiao Wang Our lab previously found that levamisole (LMS) as an adjuvant enhanced the efficacy of vaccine against infectious pathogens. However, the cellular and molecular mechanisms remain to be defined. In this study, we showed that BALB/c bone marrow-derived DC stimulated with LMS resulted in enhanced cell-surface expression of CD80, CD86, CD40 and MHC class II, as well as enhanced production of IL-12p70, TN... περισσότερα »

Cure Tinnitus By Meditating

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα

Edoxaban in patients with atrial fibrillation

Percutaneous coronary interventions and antiplatelet therapy in renal transplant recipients

Assessment of blood pressure in patients with hypertension aged 60-79 years before and after the publication of the 2014 Eighth Joint National Committee report

Early postdisaster health outreach to modern families: a cross-sectional study

Cirrhosis

A review of the cutaneous manifestations of Helicobacter cinaedi

Perseverative Error Subtypes in Patients with Alzheimer’s Disease and Mild Cognitive Impairment

The post Perseverative Error Subtypes in Patients with Alzheimer’s Disease and Mild Cognitive Impairment appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Oc8obt via IFTTT

Thyroid cancer in 2015: Molecular landscape of thyroid cancer continues to be … – Nature.com

Relationship Between Biophysical Parameters and Synthetic Indices Derived from Hyperspectral Field Data in a Salt Marsh from Buenos Aires Province, Argentina

Columnist’s cancer treatment: Crossing a bright, glowing line – Glenwood Springs Post Independent

Relationship Between Biophysical Parameters and Synthetic Indices Derived from Hyperspectral Field Data in a Salt Marsh from Buenos Aires Province, Argentina

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα

FOXO3a Mediates Glucocorticoid Function in B-ALL

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα

Glucocorticoids are widely used to treat B acute lymphoblastic leukemia (B-ALL); however, the molecular mechanism underlying glucocorticoid response and resistance is unclear. In this study, the role and regulation of FOXO3a in mediating the dexamethasone response in B-ALL were investigated. The results show that FOXO3a mediates the cytotoxic function of dexamethasone. In response to dexamethasone, …

Hypertonic saline solution for management of parotid fistula: A case report

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα

Publication date: Available online 17 December 2015 Source:Journal of Oral Biology and Craniofacial Research Author(s): Ajaz A. Shah, Nahida Dar, Mohammed Israr Ul Khaliq, Tajamul Hakeem The management of parotid fistulae has been unsatisfactory in the past, and numerous methods of treatment with varying success and morbidity have been described. A case of parotid fistula …

Srx in Colorectal Cancer Invasion and Metastasis

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα

Sulfiredoxin (SRXN1/Srx) is a multifunction enzyme with a primary antioxidant role of reducing the overoxidized inactive form of peroxiredoxins (Prxs). The function and mechanisms of Srx in cancer development are not well understood. Here, Srx is preferentially expressed in human colorectal cancer cells but not in normal colon epithelial cells. Loss-of-function studies demonstrate that knockdown …

A strategy for residual error modeling incorporating scedasticity of variance and distribution shape

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα

Abstract Nonlinear mixed effects models parameters are commonly estimated using maximum likelihood. The properties of these estimators depend on the assumption that residual errors are independent and normally distributed with mean zero and correctly defined variance. Violations of this assumption can cause bias in parameter estimates, invalidate the likelihood ratio test and preclude simulation of …

Akt-Mediated Differential Regulation of IKK/NF-{kappa}B by TSC2/mTORC1

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα

The serine/threonine protein kinase Akt plays a critical role in regulating proliferation, growth, and survival through phosphorylation of different downstream substrates. The mTOR is a key target for Akt to promote tumorigenesis. It has been reported that Akt activates mTOR through phosphorylation and inhibition of the tuberous sclerosis complex (TSC) protein TSC2. Previously, it was …

Efficacy evaluation of clonazepam for symptom remission in burning mouth syndrome: a meta-analysis

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα

miR-200c Inhibits Cell Proliferation in Renal Cell Carcinoma

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα

miRNA expression profiles are widely investigated in the major cancers, but their specific roles and functions in cancers have not yet to be fully elucidated. In this study, miRNA expression profiles were determined in clear cell renal cell carcinomas (ccRCC) and in matched normal kidney tissues by using a miRNA microarray platform which covers a …

Psychological disorders and oral lichen planus: matched case-control study and literature review

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα

A New Association for the Oral Metagenome

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα

Perceptions, Attributions, and Emotions Toward Endocrine Therapy in Young Women with Breast Cancer

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα

Journal of Adolescent and Young Adult Oncology , Vol. 0, No. 0. from Cancer via ola Kala on Inoreader http://ift.tt/1mr5TWq via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1k5WnpX via IFTTT

A case for the use of receiver operating characteristic analysis of potential clinical efficacy biomarkers in advanced renal cell carcinoma

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα

Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader http://ift.tt/1mr3xH5 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Qwy82G via IFTTT

Effective recovery of highly purified CD326 + tumor cells from lavage fluid of patients treated with a novel cell-free and concentrated ascites reinfusion therapy (KM-CART)

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα

For the production of tumor-specific vaccines, including dendritic cell (DC) vaccines, the tumor cells themselves are an ideal source. Floating tumor cells in the ascites fluid from patients with malignant ascites are a good candidate source, but it is not easy to obtain pure tumor cells from ascites because of various types of cell contamination as well as protein aggregates. We here report an effective method to recover pure tumor cells from malignant ascites. We used lavage fluid from 13 patients with malignant ascites who were treated with modified cell-free and concentrated a... περισσότερα »

Next generation sequencing of MicroRNAs from isogenic neuroblastoma cell lines isolated before and after treatment

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα

• RNAseq of neuroblastoma cell lines isolated pre- and post treatment• Identified 42 differentially expressed miRNAs• 8 miRNAs were upregulated and 34 downregulated• 65% of the downregulated miRNAs are encoded by the 14q32 miRNA clusters• Reduced expression of 14q32 miRNAs in tumors is associated with poor prognosis factors• IPA reveals functions and pathways associated with cancer progression and drug resistance from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1mbrrWJ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis o...περισσότερα »

Long-term Results of a Multicenter Randomized Phase III Trial of Induction Chemotherapy With Cisplatin, 5-fluorouracil, {+/-} Docetaxel for Larynx Preservation

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα

Background: The purpose of GORTEC 2000–01 was to compare the long-term efficacy and safety of induction chemotherapy with cisplatin (P) and 5-fluorouracil (F) with or without docetaxel (T) for larynx preservation. Methods: Operable patients with untreated stage III or IV larynx or hypopharynx invasive squamous cell carcinoma who required total laryngectomy were randomly assigned to three cycles of induction chemotherapy with either TPF or PF, followed by radiation therapy for responders. The primary endpoint was three-year larynx preservation rate. Secondary endpoints included l... περισσότερα »

Ectopic Subcutaneous Implantation of Thyroid Tissue After Gasless Transaxillary Robotic Thyroidectomy for Papillary Thyroid Cancer

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα

Thyroid Dec 2015, Vol. 25, No. 12: 1381-1382. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RVFI6j via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Oc6szX via IFTTT

Future Meetings

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα

Thyroid Dec 2015, Vol. 25, No. 12: 1383-1384. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Mkn7K5 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UHhSuA via IFTTT

Features Predictive of Distant Metastasis in Papillary Thyroid Microcarcinomas

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα

Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RVFHPT via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RsyiZ9 via IFTTT

2015 American Thyroid Association Guidelines for Thyroid Nodules and Differentiated Thyroid Cancer and Their Implementation in Various Care Settings

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα

Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RVFHPJ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1JfM49q via IFTTT

Histopathologic and Clinical Characterization of Thyroid Tumors Carrying the BRAFK601E Mutation

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα

Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Mkn9lf via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RsylnE via IFTTT

Oral purpura as the first manifestation of primary systemic amyloidosis

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα

Oral blood blisters and purpura are rare features of primary systemic amyloidosis (amyloid light-chain (AL) amyloidosis). We report a case in which these unusual presentations led to a diagnosis of amyloidosis, which enabled effective treatment before organ failure. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1NARuxz via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1NWua0W via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1JfM2OX via IFTTT

Oral purpura as the first manifestation of primary systemic amyloidosis

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα

Oral blood blisters and purpura are rare features of primary systemic amyloidosis (amyloid light-chain (AL) amyloidosis). We report a case in which these unusual presentations led to a diagnosis of amyloidosis, which enabled effective treatment before organ failure. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NARuxz via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Rsylnz via IFTTT

Regional control is preserved after dose de-escalated radiotherapy to involved lymph nodes in HPV positive oropharyngeal cancer

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα

Patients with HPV positive oropharyngeal squamous cell carcinoma (OPSCC) are known to have a significantly more favorable prognosis than their HPV negative counterparts [1]. The substantially better prognosis of these patients has created new challenges in determining the optimal treatment approach. While concurrent chemoradiotherapy to 70Gy is presently the standard of care for OPSCC, this recommendation is based on randomized clinical trials which were dominated by HPV negative patients. As a result, it is difficult to extrapolate from historical trials to determine the optimal ...περισσότερα »

Prospective biomechanical evaluation of donor site morbidity after radial forearm free flap

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα

Although the radial forearm free flap (RFF) is a commonly-used microvascular flap for orofacial reconstruction, we are aware of few prospective biomechanical studies of the donor site. We have therefore evaluated the donor site morbidity biomechanically of 30 consecutive RFF for orofacial reconstruction preoperatively and three months postoperatively. This included the Mayo wrist score, the Disabilities of the Arm, Shoulder and Hand (DASH) score, grip strength, followed by tip pinch, key pinch, palmar pinch, and range of movement of the wrist. from #ΓναθοΧειρουργική via xlomafota1... περισσότερα »

Prospective biomechanical evaluation of donor site morbidity after radial forearm free flap

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα

Although the radial forearm free flap (RFF) is a commonly-used microvascular flap for orofacial reconstruction, we are aware of few prospective biomechanical studies of the donor site. We have therefore evaluated the donor site morbidity biomechanically of 30 consecutive RFF for orofacial reconstruction preoperatively and three months postoperatively. This included the Mayo wrist score, the Disabilities of the Arm, Shoulder and Hand (DASH) score, grip strength, followed by tip pinch, key pinch, palmar pinch, and range of movement of the wrist. from #Medicine-SfakianakisAlexandros ... περισσότερα »

Canadian runner Bishop says she’s stronger for troubles she, coach have faced – Windsor Star

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα

[image: 1T58oIB] Windsor Star *Canadian runner Bishop says she's stronger for troubles she, coach have faced* *Windsor Star* After beating *cancer* of the *larynx*, the 62-year-old was diagnosed two years ago with progressive supranuclear palsy — PSP — a degenerative condition that results from deterioration of cells in the brain that control body movement and thinking. It has *…* *and more »* from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1IXMkiv via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://if... περισσότερα »

Hypertonic saline solution for management of parotid fistula: A case report

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 45 δευτερόλεπτα

Publication date: Available online 17 December 2015 *Source:*Journal of Oral Biology and Craniofacial Research Author(s): Ajaz A. Shah, Nahida Dar, Mohammed Israr Ul Khaliq, Tajamul Hakeem The management of parotid fistulae has been unsatisfactory in the past, and numerous methods of treatment with varying success and morbidity have been described. A case of parotid fistula caused by damage to glandular elements during a transparotid approach for a subcondylar fracture reduction is reported. This paper presents a simple but effective and conservative method of treating this complica...περισσότερα »

Efficacy evaluation of clonazepam for symptom remission in burning mouth syndrome: a meta-analysis

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 45 δευτερόλεπτα

Abstract Objectives Clonazepam has been used in the treatment of burning mouth syndrome (BMS) for several decades. We conducted a meta-analysis to investigate the efficacy of clonazepam in the treatment of BMS. Methods We conducted a search of the PubMed, Medline, EMBASE, Web of Science (TS), and the Cochrane Library databases for relevant studies that met our eligibility criteria (up to September 22, 2015). Statistical analyses were conducted using RevMan 5.2 and STATA 11.0 software. Results Three randomized controlled trials (RCTs) and two high-quality case-control studies in...περισσότερα »

A strategy for residual error modeling incorporating scedasticity of variance and distribution shape

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα

Hypertonic saline solution for management of parotid fistula: A case report

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα

Efficacy evaluation of clonazepam for symptom remission in burning mouth syndrome: a meta-analysis

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα

Psychological disorders and oral lichen planus: matched case-control study and literature review

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα

A New Association for the Oral Metagenome

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα

Dual AR/Myc Targeting Effectively Blocks Cancer Cell Growth

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα

The bioactive sphingolipid sphingosine-1-phosphate (S1P) drives several hallmark processes of cancer, making the enzymes that synthesize S1P, that is, sphingosine kinase 1 and 2 (SK1 and SK2), important molecular targets for cancer drug development. ABC294640 is a first-in-class SK2 small-molecule inhibitor that effectively inhibits cancer cell growth in vitro and in vivo. Given that AR […]

UBR5 in Cancer

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα

The Ubiquitin-Proteasome System (UPS) is an important regulator of cell signaling and proteostasis, which are essential to a variety of cellular processes. The UPS is disrupted in many diseases including cancer, and targeting the UPS for cancer therapy is gaining wide interest. E3 ubiquitin ligases occupy a key position in the hierarchical UPS enzymatic cascade, […]

Selected Articles from This Issue

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/22cgNQD via IFTTT

Hypoxia Promotes Synergy between Mitomycin C and Bortezomib

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα

Colorectal peritoneal carcinomatosis (CPC) exhibits severe tumor hypoxia, leading to drug resistance and disease aggressiveness. This study demonstrates that the combination of the chemotherapeutic agent mitomycin C with the proteasome inhibitor bortezomib induced synergistic cytotoxicity and apoptosis, which was even more effective under hypoxia in colorectal cancer cells. The combination of mitomycin C and bortezomib […]

IR Confers Resistance to IGF-IR Antibody

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα

Despite a recent shift away from anti–insulin-like growth factor I receptor (IGF-IR) therapy, this target has been identified as a key player in the resistance mechanisms to various conventional and targeted agents, emphasizing its value as a therapy, provided that it is used in the right patient population. Molecular markers predictive of antitumor activity of […]

Psychological disorders and oral lichen planus: matched case-control study and literature review

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα

A New Association for the Oral Metagenome

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα

Abstract Genome-wide association studies (GWAS) have been used extensively to catalogue human gene variation in health and disease. This approach can be extended to metagenome-wide association studies (MGWAS), in which changes in the total microbial gene content at a body site are correlated with a particular disease. Although MGWAS has been employed widely to identify key associations between the gut metagenome and disease, relatively few MGWAS have analysed the oral microbiota and these have generally focussed on dental caries and periodontitis. A recent paper has reported the fi... περισσότερα »

Akt-Mediated Differential Regulation of IKK/NF-{kappa}B by TSC2/mTORC1

miR-200c Inhibits Cell Proliferation in Renal Cell Carcinoma

Acknowledgment to Reviewers

from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1MkpyMP via IFTTT

Enlarged lateral ventricles inversely correlate with reduced corpus callosum central volume in first episode schizophrenia: association with functional measures

Abstract The lateral and third ventricles, as well as the corpus callosum (CC), are known to be affected in schizophrenia. Here we investigate whether abnormalities in the lateral ventricles (LVs), third ventricle, and corpus callosum are related to one another in first episode schizophrenia (FESZ), and whether such abnormalities show progression over time. Nineteen FESZ […]

Effects of High Doses of Vitamin C on Cancer Patients in Singapore: Nine Cases

Introduction. Intravenous high-dose vitamin C therapy is widely used in naturopathic and integrative oncology; however, a study reviewing its effects has never been performed in Singapore. This article serves to document administration of supportive vitamin C therapy for cancer patients in Singapore. Methods. The clinical response of 9 cancer patients of differing stages to the […]

Prosthetic-Joint-Associated Bordetella holmesii Infection

Economic Impact of Meningococcal Outbreaks in Brazil and Colombia

Recovery from Mild Traumatic Brain Injury in Previously Healthy Adults

Journal of Neurotrauma , Vol. 0, No. 0. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1UHhOem via IFTTT

Trigeminal Pain Molecules, Allodynia, and Photosensitivity Are Pharmacologically and Genetically Modulated in a Model of Traumatic Brain Injury

Journal of Neurotrauma , Vol. 0, No. 0. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1YlyVb9 via IFTTT

Prospective Study on Noninvasive Assessment of Intracranial Pressure in Traumatic Brain-Injured Patients: Comparison of Four Methods

Journal of Neurotrauma , Vol. 0, No. 0. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1T5b9JO via IFTTT

Regional control is preserved after dose de-escalated radiotherapy to involved lymph nodes in HPV positive oropharyngeal cancer

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα

Celiac disease-related hepatic injury: Insights into associated conditions and underlying pathomechanisms

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα

Celiac disease (CD) is the most common autoimmune enteropathy. Clinical manifestations may range from a typical malabsorption syndrome to several apparently unrelated extra-intestinal symptoms. from C via ola Kala on Inoreader http://ift.tt/1ZfcfGx via IFTTT

Regional control is preserved after dose de-escalated radiotherapy to involved lymph nodes in HPV positive oropharyngeal cancer

otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Oral purpura as the first manifestation of primary systemic amyloidosis

otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Prospective biomechanical evaluation of donor site morbidity after radial forearm free flap

otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα

A Novel Closed-Head Model of Mild Traumatic Brain Injury Using Focal Primary Overpressure Blast to the Cranium in Mice

otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Journal of Neurotrauma , Vol. 0, No. 0. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1YlyVIa via IFTTT

Recovery from Mild Traumatic Brain Injury in Previously Healthy Adults

otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Journal of Neurotrauma , Vol. 0, No. 0. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1UHhOem via IFTTT

Trigeminal Pain Molecules, Allodynia, and Photosensitivity Are Pharmacologically and Genetically Modulated in a Model of Traumatic Brain Injury

otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Journal of Neurotrauma , Vol. 0, No. 0. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1YlyVb9 via IFTTT

Prospective Study on Noninvasive Assessment of Intracranial Pressure in Traumatic Brain-Injured Patients: Comparison of Four Methods

otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Journal of Neurotrauma , Vol. 0, No. 0. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1T5b9JO via IFTTT

Hidden Perils of the “Wild Blue Yonder” after Traumatic Brain Injury

otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Journal of Neurotrauma , Vol. 0, No. 0. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1IcuEQd via IFTTT

Responsiveness, Sensitivity, and Minimally Detectable Difference of the Graded and Redefined Assessment of Strength, Sensibility, and Prehension, Version 1.0

otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα

Journal of Neurotrauma , Vol. 0, No. 0. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1QtfyZx via IFTTT

Pure orbital blowout fractures reconstructed with autogenous bone grafts: functional and aesthetic outcomes

otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα

The econobiology of pancreatic acinar cells granule inventory and the stealthy nano-machine behind it

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα

Publication date: Available online 17 December 2015 *Source:*Acta Histochemica Author(s): Ilan Hammel, Isaac Meilijson The pancreatic gland secretes most of the enzymes and many other macromolecules needed for food digestion in the gastrointestinal tract. These molecules play an important role in digestion, host defense and lubrication. The secretion of pancreatic proteins ensures the availability of the correct mix of proteins when needed. This review describes model systems available for the study of the econobiology of secretory granule content. The secretory pancreatic molecules...περισσότερα »