Komplette N.-peronaeus-Ruptur bei Kniedistorsion
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
Zusammenfassung Über eine komplette Ruptur des N. peronaeus wird als Folge schwerwiegender Traumen mit Kniegelenkluxationen oder nach scharfen Weichteiltraumen berichtet. Wir beschreiben den Fall eines 54-jährigen, gut trainierten Patienten, der infolge einer Kniegelenkdistorsion ohne Fremdeinwirkung ein Komplextrauma mit vollständiger Kontinuitätsunterbrechung des Nervs erlitt. Der Primärbefund imponierte wenig dramatisch, insbesondere ließen weder die Unfallanamnese noch die […]
Orthopädie/Unfallchirurgie und Recht
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UDY8YW via IFTTT
Rational design of α-helical tandem repeat proteins with closed architectures
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
Tandem repeat proteins, which are formed by repetition of modular units of protein sequence and structure, play important biological roles as macromolecular binding and scaffolding domains, enzymes, and building blocks for the assembly of fibrous materials. The modular nature of repeat proteins enables the rapid construction and diversification of extended binding surfaces by duplication and […]
Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
Specificity protein (Sp) transcription factors play pivotal roles in maintaining the phenotypes of many cancers. We hypothesized that the antineoplastic effects of sulindac and its metabolites were due, in par… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1MiTOHF via IFTTT
Choroidal metastases from thymic carcinoma during pregnancy: Case Report
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
Rare sites of metastases, atypical symptoms and paraneoplastic syndromes are often neglected or misinterpreted, especially when they represent early symptoms of an underlying malignant disease. Hence, an inter… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1IWgEKt via IFTTT
Cytokeratin 20 positive circulating tumor cells are a marker for response after neoadjuvant chemoradiation but not for prognosis in patients with rectal cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
Several studies have shown, that circulating tumor cells (CTC) have a negative prognostic value in colorectal cancer patients. Aim of this study was to evaluate the role of CTC in specifically rectal cancer pa… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1MiTOrc via IFTTT
Evaluation of KIF23 variant 1 expression and relevance as a novel prognostic factor in patients with hepatocellular carcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
KIF23 (kinesin family member 23) is a kinesin-like motor protein and plays an important role in cytokinesis. In search for genes associated with hepatocellular carcinoma (HCC) by cDNA microarray, we found that… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1MiTMzK via IFTTT
Methylation status of COX-2 in blood leukocyte DNA and risk of gastric cancer in a high-risk Chinese population
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
Methylation is a common epigenetic modification which may play a crucial role in cancer development. To investigate the association between methylation of COX-2 in blood leukocyte DNA and risk of gastric cancer (… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1MiTh8B via IFTTT
Long-term outcomes in medial flap inferior turbinoplasty are superior to submucosal electrocautery and submucosal powered turbinate reduction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
Background Techniques for inferior turbinate reduction vary from complete turbinectomy to limited cauterization. Surgical methods differ on the degree of tissue reduction and reliance on surgical tissue removal vs tissue ablation. The outcome and morbidity from 3 different turbinate techniques are compared. Methods A randomized double-blinded study was performed. Patient nasal cavities were randomized to […]
Prevalence of confirmed asthma varies in chronic rhinosinusitis subtypes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
Background Chronic rhinosinusitis (CRS) and asthma describe inflammation of the upper and lower airway, respectively. Not surprisingly, the prevalence of CRS and asthma has been linked, with up to 50% asthma prevalence in CRS with nasal polyposis (CRSwNP) patients. However, these prevalence rates do not address subtypes of CRSwNP including allergic fungal rhinosinusitis (AFRS). This […]
Prediction of iodine-131 biokinetics and radiation doses from therapy on the basis of tracer studies: an important question for therapy planning in nuclear medicine.
Alexandros G. SfakianakisστοHead and NeckΠριν από 3 δευτερόλεπτα
*Prediction of iodine-131 biokinetics and radiation doses from therapy on the basis of tracer studies: an important question for therapy planning in nuclear medicine.* Nucl Med Commun. 2015 Dec 14; Authors: Willegaignon J, Pelissoni RA, Lima BC, Sapienza MT, Coura-Filho GB, Buchpiguel CA Abstract OBJECTIVES: This study aimed to present a comparison of iodine-131 (I) biokinetics and radiation doses to red-marrow (rm) and whole-body (wb), following the administration of tracer and therapeutic activities, as a means of confirming whether I clearance and radiation doses for therapy ... περισσότερα »
Cardiac neuroendocrine tumour metastases: case reports and review of the literature.
Alexandros G. SfakianakisστοHead and NeckΠριν από 3 δευτερόλεπτα
*Cardiac neuroendocrine tumour metastases: case reports and review of the literature.* Nucl Med Commun. 2015 Dec 14; Authors: Bonsen LR, Aalbersberg E, Tesselaar M, Stokkel MP Abstract BACKGROUND: Most neuroendocrine tumours (NETs) metastasize to the liver, lymph nodes and, although less frequently, to the bone. The heart is a rare localization for NET metastases. METHODS: With the introduction of the Ga-DOTATATE PET/computed tomography (CT) in our hospital as a new diagnostic method for imaging neuroendocrine tumours, more rare metastatic localizations are being found. We presen... περισσότερα »
Angiogenesis inhibitor; +34 new citations
Alexandros G. SfakianakisστοHead and NeckΠριν από 3 δευτερόλεπτα
34 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *Angiogenesis inhibitor* These pubmed results were generated on 2015/12/17 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 1 via ola Kala on Inoreader http://ift.tt/QGMHBq(((Angiogenesis%20inhibitor)%20AND%20%222015%2F12%2F15%2012.57%22%5BMHDA%5D%3A%222015%2F12%2F1... περισσότερα »
Function of obturator prosthesis after maxillectomy and prosthetic obturator rehabilitation.
Alexandros G. SfakianakisστοHead and NeckΠριν από 3 δευτερόλεπτα
*Function of obturator prosthesis after maxillectomy and prosthetic obturator rehabilitation.* Braz J Otorhinolaryngol. 2015 Nov 6; Authors: Chen C, Ren W, Gao L, Cheng Z, Zhang L, Li S, Zhi PK Abstract INTRODUCTION: Maxillary defects are usually rehabilitated by a prosthetic obturator. OBJECTIVE: This study aimed to evaluate the functioning of obturators prosthesis in patients with unilateral defects after maxillectomy. METHODS: Of 49 patients, 28 underwent to maxillectomy as a result of tumor ablative surgery, and acquired unilateral maxillary defects. Evaluation of the functio... περισσότερα »
The learning progression of diagnostic sialendoscopy.
Alexandros G. SfakianakisστοHead and NeckΠριν από 3 δευτερόλεπτα
*The learning progression of diagnostic sialendoscopy.* Braz J Otorhinolaryngol. 2015 Nov 6; Authors: Steck JH, Stabenow E, Volpi EM, Vasconcelos EC Abstract INTRODUCTION: Sialendoscopy is becoming the gold standard procedure for diagnosis and treatment of Salivary Gland Inflammatory Diseases. OBJECTIVE: To evaluate the learning progression of a single surgeon to implement and perform diagnostic sialendoscopy: to estimate how many procedures were necessary to achieve better results; if it was higher rate of complications in the beginning. METHODS: Retrospective analysis involving ...περισσότερα »
Orofacial-cervical alterations in individuals with upper airway resistance syndrome.
Alexandros G. SfakianakisστοHead and NeckΠριν από 3 δευτερόλεπτα
*Orofacial-cervical alterations in individuals with upper airway resistance syndrome.* Braz J Otorhinolaryngol. 2015 Nov 6; Authors: de Oliveira PW, Gregorio LL, Silva RS, Bittencourt LR, Tufik S, Gregório LC Abstract INTRODUCTION: Studies that assess the upper airways in sleep-related breathing disorders have been performed only in patients with obstructive sleep apnea syndrome who seek medical attention. Therefore, in addition to the need for population studies, there are no data on the orofacial-cervical physical examination in subjects with upper airway resistance syndrome.... περισσότερα »
Economic Valuation of the Global Burden of Cleft Disease Averted by a Large Cleft Charity.
Alexandros G. SfakianakisστοHead and NeckΠριν από 3 δευτερόλεπτα
*Economic Valuation of the Global Burden of Cleft Disease Averted by a Large Cleft Charity.* World J Surg. 2015 Dec 15; Authors: Poenaru D, Lin D, Corlew S Abstract BACKGROUND: This study attempts to quantify the burden of disease averted through the global surgical work of a large cleft charity, and estimate the economic impact of this effort over a 10-year period. METHODS: Anonymized data of all primary cleft lip and cleft palate procedures in the Smile Train database were analyzed and disability-adjusted life years (DALYs) calculated using country-specific life expectancy tab...περισσότερα »
Molecular Characteristics of Large Parathyroid Adenomas.
Alexandros G. SfakianakisστοHead and NeckΠριν από 3 δευτερόλεπτα
*Molecular Characteristics of Large Parathyroid Adenomas.* World J Surg. 2015 Dec 15; Authors: Agarwal A, Pradhan R, Kumari N, Krishnani N, Shukla P, Gupta SK, Chand G, Mishra A, Agarwal G, Verma AK, Mishra SK Abstract INTRODUCTION: The clinical entity of large parathyroid adenomas (LPTAs) has not been well defined. It is speculated that LPTAs would have biochemical, histological, and molecular characteristics different from small adenomas. Our study aimed to find out occurrence of atypia and carcinomas in large parathyroid lesions and the presence of distinct molecular abnormali... περισσότερα »
First Episode of Spontaneous Pneumothorax: CT-based Scoring to Select Patients for Early Surgery.
Alexandros G. SfakianakisστοHead and NeckΠριν από 3 δευτερόλεπτα
*First Episode of Spontaneous Pneumothorax: CT-based Scoring to Select Patients for Early Surgery.* World J Surg. 2015 Dec 15; Authors: Primavesi F, Jäger T, Meissnitzer T, Buchner S, Reich-Weinberger S, Öfner D, Hutter J, Aspalter M Abstract BACKGROUND: Although recurrence of primary spontaneous pneumothorax (PSP) is frequent, guidelines do not routinely recommend surgery after first presentation. A CT-based lung dystrophy severity score (DSS) has recently been proposed to predict recurrence following conservative therapy. This study compares the DSS in surgically and conservat...περισσότερα »
Inequitable Access to Timely Cleft Palate Surgery in Low- and Middle-Income Countries.
Alexandros G. SfakianakisστοHead and NeckΠριν από 3 δευτερόλεπτα
*Inequitable Access to Timely Cleft Palate Surgery in Low- and Middle-Income Countries.* World J Surg. 2015 Dec 15; Authors: Carlson LC, Hatcher KW, Tomberg L, Kabetu C, Ayala R, Vander Burg R Abstract BACKGROUND: Delayed cleft palate repair has significant implications for physical, mental, and social well-being and has been suggested to lead to an increased risk of infant and under-five mortality in low- and middle-income countries (LMICs). METHODS: Using medical records from Operation Smile international programs taking place in eleven different LMICs between March and May 201...περισσότερα »
Where Oncologic and Surgical Complication Scoring Systems Collide: Time for a New Consensus for CRS/HIPEC.
Alexandros G. SfakianakisστοHead and NeckΠριν από 3 δευτερόλεπτα
*Where Oncologic and Surgical Complication Scoring Systems Collide: Time for a New Consensus for CRS/HIPEC.* World J Surg. 2015 Dec 15; Authors: Lehmann K, Eshmuminov D, Slankamenac K, Kranzbühler B, Clavien PA, Vonlanthen R, Gertsch P Abstract INTRODUCTION: Morbidity and mortality rates after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are important quality parameters to compare peritoneal surface malignancy centers. A major problem to assess postoperative outcomes among centers is the inconsistent reporting due to two coexisting systems, t... περισσότερα »
Severity of Acute Cholecystitis and Risk of Iatrogenic Bile Duct Injury During Cholecystectomy, a Population-Based Case-Control Study.
Alexandros G. SfakianakisστοHead and NeckΠριν από 3 δευτερόλεπτα
*Severity of Acute Cholecystitis and Risk of Iatrogenic Bile Duct Injury During Cholecystectomy, a Population-Based Case-Control Study.* World J Surg. 2015 Dec 15; Authors: Törnqvist B, Waage A, Zheng Z, Ye W, Nilsson M Abstract BACKGROUND: Acute cholecystitis is a common complication to gallstone disease. The relation between the severity of acute cholecystitis and risk of bile duct injury during cholecystectomy has not yet been addressed and is the main focus of this study. METHODS: All cases with iatrogenic bile duct injury during cholecystectomy, within the Lake Mälaren regio...περισσότερα »
Implementation of Enhanced Recovery (ERAS) in Colorectal Surgery Has a Positive Impact on Non-ERAS Liver Surgery Patients.
Alexandros G. SfakianakisστοHead and NeckΠριν από 3 δευτερόλεπτα
*Implementation of Enhanced Recovery (ERAS) in Colorectal Surgery Has a Positive Impact on Non-ERAS Liver Surgery Patients.* World J Surg. 2015 Dec 14; Authors: Labgaa I, Jarrar G, Joliat GR, Allemann P, Gander S, Blanc C, Hübner M, Demartines N Abstract BACKGROUND: Enhanced recovery after surgery (ERAS) reduces complications and hospital stay in colorectal surgery. Thereafter, ERAS principles were extended to liver surgery. Previous implementation of an ERAS program in colorectal surgery may influence patients undergoing liver surgery in a non-ERAS setting, on the same ward. Th... περισσότερα »
Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis.* Brain. 2015 Dec 14; Authors: Jürgens T, Jafari M, Kreutzfeldt M, Bahn E, Brück W, Kerschensteiner M, Merkler D Abstract Grey matter pathology has emerged as an important contributor to long-term disability in multiple sclerosis. To better understand where and how neuronal damage in the grey matter is initiated, we used high resolution confocal microscopy of Golgi-Cox impregnated tissue sections and reconstructed single cortical projection neurons in autopsies from eight pati... περισσότερα »
The chemokine receptor CXCR7 influences prognosis in human glioma in an IDH1-dependent manner.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *The chemokine receptor CXCR7 influences prognosis in human glioma in an IDH1-dependent manner.* J Clin Pathol. 2015 Oct;68(10):830-4 Authors: Birner P, Tchorbanov A, Natchev S, Tuettenberg J, Guentchev M Abstract AIMS: The chemokine receptor CXCR7 is found on glioma cells and glioma-associated vessels and dependent upon its localisation on tumour or endothelial cells the CXCR7 receptor can mediate glioma cell invasion and tumour angiogenesis. Its expression predicts survival in several types of cancers. METHODS: ... περισσότερα »
Factors Impacting Functional Status in Veterans of Recent Conflicts With PTSD.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Factors Impacting Functional Status in Veterans of Recent Conflicts With PTSD.* J Neuropsychiatry Clin Neurosci. 2015 Dec 16;:appineuropsych15070183 Authors: Kozel FA, Didehbani N, DeLaRosa B, Bass C, Schraufnagel CD, Morgan CR, Jones P, Spence JS, Hart J Abstract Veterans with posttraumatic stress disorder (PTSD) underwent a systematic evaluation to determine which factors were associated with the degree of functional status. Demographic information, self-report scales, and symptom ratings performed by trained evaluators were investigated in multiple regression models to deter... περισσότερα »
Triaging older major trauma patients in the emergency department: an observational study.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Triaging older major trauma patients in the emergency department: an observational study.* Emerg Med J. 2015 Apr;32(4):281-6 Authors: Lukin W, Greenslade JH, Chu K, Lang J, Brown AF Abstract BACKGROUND: The objective of this study was to compare the triage category assigned to older trauma patients with younger trauma patients upon arrival to the emergency department. The focus was to examine whether older major trauma patients were less likely to be assigned an emergency triage category on arrival to the emergen...περισσότερα »
Implementing oral chemotherapy services in community pharmacies: a qualitative study of chemotherapy nurses' and pharmacists' views.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Implementing oral chemotherapy services in community pharmacies: a qualitative study of chemotherapy nurses' and pharmacists' views.* Int J Pharm Pract. 2015 Dec 16; Authors: Butt F, Ream E Abstract OBJECTIVES: Changes in health-care provision have led to cancer patients being offered oral chemotherapy in the community. Three levels of oral chemotherapy services have been proposed (levels 1, 2 and 3) with community pharmacies playing differing roles within them. This study aims to explore health-care professionals' views on oral chemotherapy services being delivered by communit... περισσότερα »
Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets.* Acta Neuropathol. 2015 Dec 15; Authors: Sahm F, Schrimpf D, Jones DT, Meyer J, Kratz A, Reuss D, Capper D, Koelsche C, Korshunov A, Wiestler B, Buchhalter I, Milde T, Selt F, Sturm D, Kool M, Hummel M, Bewerunge-Hudler M, Mawrin C, Schüller U, Jungk C, Wick A, Witt O, Platten M, Herold-Mende C, Unterberg A, Pfister SM, Wick W, von Deimling A Abstract With the number of prognostic and predictive genetic markers in neuro-oncology steadily growing, the ... περισσότερα »
Evolution and emerging future of cytoreducxtive surgery and hyperthermic intraperitoneal chemoperfusion in gastric cancer: From treating the incurable to preventing recurrence.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Evolution and emerging future of cytoreducxtive surgery and hyperthermic intraperitoneal chemoperfusion in gastric cancer: From treating the incurable to preventing recurrence.* Int J Hyperthermia. 2015 Dec 15;:1-7 Authors: Polom K, Marano L, Roviello G, Petrioli R, Piagnerelli R, de Franco L, Marrelli D, Roviello F Abstract The number of new gastric cancer (GC) cases is decreasing, and these patients have longer survival thanks to new oncological treatments. In advanced GC a common evolution of this neoplasm is peritoneal metastases (PM). In the past this finding meant no chan... περισσότερα »
Anaplastic Lymphoma Kinase (ALK) Signaling in Lung Cancer.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Anaplastic Lymphoma Kinase (ALK) Signaling in Lung Cancer.* Adv Exp Med Biol. 2016;893:179-187 Authors: Ou SI, Shirai K Abstract Chromosomal rearrangement in the anaplastic lymphoma kinase (ALK) gene was identified as an oncogenic driver in non-small cell lung cancer (NSCLC) in 2007. A multi-targeted ALK/ROS1/MET inhibitor, crizotinib, targeting this activated tyrosine kinase has led to significant clinical benefit including tumor shrinkage and prolonged survival without disease progression and has been approved by US FDA since 2011 for the treatment of advanced ALK-rearranged ...περισσότερα »
Concealing Emotions at Work Is Associated with Allergic Rhinitis in Korea.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Concealing Emotions at Work Is Associated with Allergic Rhinitis in Korea.* Tohoku J Exp Med. 2016;238(1):25-32 Authors: Seok H, Yoon JH, Won JU, Lee W, Lee JH, Jung PK, Roh J Abstract Concealing emotions at work can cause considerable psychological stress. While there is extensive research on the adverse health effects of concealing emotions and the association between allergic diseases and stress, research has not yet investigated whether concealing emotions at work is associated with allergic rhinitis. Allergic rhinitis is a common disease in many industrialized countries, an...περισσότερα »
Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside.* Basic Res Cardiol. 2016 Jan;111(1):7 Authors: Cabrera-Fuentes HA, Alba-Alba C, Aragones J, Bernhagen J, Boisvert WA, Bøtker HE, Cesarman-Maus G, Fleming I, Garcia-Dorado D, Lecour S, Liehn E, Marber MS, Marina N, Mayr M, Perez-Mendez O, Miura T, Ruiz-Meana M, Salinas-Estefanon EM, Ong SB, Schnittler HJ, Sanchez-Vega JT, Sumoza-Toledo A, Vogel CW, Yarullina D, Yellon DM, Preissner KT, Hausenloy DJ Abstrac... περισσότερα »
Innovation in medicine: Ignaz the reviled and Egas the regaled.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Innovation in medicine: Ignaz the reviled and Egas the regaled.* Med Health Care Philos. 2015 Dec 14; Authors: Csoka AB Abstract In our current climate of rapid technological progress, it seems counterintuitive to think that modern science can learn anything of ethical value from the dark recesses of the nineteenth century or earlier. However, this happens to be quite true, with plenty of knowledge and wisdom to be gleaned by studying our scientific predecessors. Presently, our journals are flooded with original concepts and potential breakthroughs, a continuous stream of ideas... περισσότερα »
Implementing oral chemotherapy services in community pharmacies: a qualitative study of chemotherapy nurses' and pharmacists' views.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Implementing oral chemotherapy services in community pharmacies: a qualitative study of chemotherapy nurses' and pharmacists' views.* Int J Pharm Pract. 2015 Dec 16; Authors: Butt F, Ream E Abstract OBJECTIVES: Changes in health-care provision have led to cancer patients being offered oral chemotherapy in the community. Three levels of oral chemotherapy services have been proposed (levels 1, 2 and 3) with community pharmacies playing differing roles within them. This study aims to explore health-care professionals' views on oral chemotherapy services being delivered by communit... περισσότερα »
Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets.* Acta Neuropathol. 2015 Dec 15; Authors: Sahm F, Schrimpf D, Jones DT, Meyer J, Kratz A, Reuss D, Capper D, Koelsche C, Korshunov A, Wiestler B, Buchhalter I, Milde T, Selt F, Sturm D, Kool M, Hummel M, Bewerunge-Hudler M, Mawrin C, Schüller U, Jungk C, Wick A, Witt O, Platten M, Herold-Mende C, Unterberg A, Pfister SM, Wick W, von Deimling A Abstract With the number of prognostic and predictive genetic markers in neuro-oncology steadily growing, the ... περισσότερα »
Evolution and emerging future of cytoreducxtive surgery and hyperthermic intraperitoneal chemoperfusion in gastric cancer: From treating the incurable to preventing recurrence.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Evolution and emerging future of cytoreducxtive surgery and hyperthermic intraperitoneal chemoperfusion in gastric cancer: From treating the incurable to preventing recurrence.* Int J Hyperthermia. 2015 Dec 15;:1-7 Authors: Polom K, Marano L, Roviello G, Petrioli R, Piagnerelli R, de Franco L, Marrelli D, Roviello F Abstract The number of new gastric cancer (GC) cases is decreasing, and these patients have longer survival thanks to new oncological treatments. In advanced GC a common evolution of this neoplasm is peritoneal metastases (PM). In the past this finding meant no chan... περισσότερα »
Anaplastic Lymphoma Kinase (ALK) Signaling in Lung Cancer.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Anaplastic Lymphoma Kinase (ALK) Signaling in Lung Cancer.* Adv Exp Med Biol. 2016;893:179-187 Authors: Ou SI, Shirai K Abstract Chromosomal rearrangement in the anaplastic lymphoma kinase (ALK) gene was identified as an oncogenic driver in non-small cell lung cancer (NSCLC) in 2007. A multi-targeted ALK/ROS1/MET inhibitor, crizotinib, targeting this activated tyrosine kinase has led to significant clinical benefit including tumor shrinkage and prolonged survival without disease progression and has been approved by US FDA since 2011 for the treatment of advanced ALK-rearranged ...περισσότερα »
Registering prostate external beam radiotherapy with a boost from high-dose-rate brachytherapy: a comparative evaluation of deformable registration algorithms.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Registering prostate external beam radiotherapy with a boost from high-dose-rate brachytherapy: a comparative evaluation of deformable registration algorithms.* Radiat Oncol. 2015;10(1):254 Authors: Moulton CR, House MJ, Lye V, Tang CI, Krawiec M, Joseph DJ, Denham JW, Ebert MA Abstract BACKGROUND: Registering CTs for patients receiving external beam radiotherapy (EBRT) with a boost dose from high-dose-rate brachytherapy (HDR) can be challenging due to considerable image discrepancies (e.g. rectal fillings, HDR needles, HDR artefacts and HDR rectal packing materials). This stu... περισσότερα »
Class I and II HLA antibodies in pediatric patients with thalassemia major.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Class I and II HLA antibodies in pediatric patients with thalassemia major.* Transfusion. 2015 Dec 15; Authors: Yee ME, Shah A, Anderson AR, Boudreaux J, Bray RA, Gebel HM, Josephson CD Abstract BACKGROUND: HLA alloimmunization is a potential complication of red blood cell (RBC) transfusion with detrimental consequences for future organ or hematopoietic stem cell transplantation. STUDY DESIGN AND METHODS: The study aimed to determine the prevalence and specificity of HLA antibodies among pediatric patients with thalassemia major (TM) and antibody changes over time while on leuk... περισσότερα »
Osteosarcoma: Current Treatment and a Collaborative Pathway to Success.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Osteosarcoma: Current Treatment and a Collaborative Pathway to Success.* J Clin Oncol. 2015 Sep 20;33(27):3029-35 Authors: Isakoff MS, Bielack SS, Meltzer P, Gorlick R Abstract Osteosarcoma is the bone tumor that most commonly affects children, adolescents, and young adults. Before 1970, treatment primarily included surgical resection. However, the introduction of chemotherapy led to a dramatic improvement in prognosis for patients with localized osteosarcoma; long-term survival rates of less than 20% improved to ...περισσότερα »
Assessment of elasticity of colorectal cancer tissue, clinical utility, pathological and phenotypical relevance.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-18-Wi] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Assessment of elasticity of colorectal cancer tissue, clinical utility, pathological and phenotypical relevance.* Cancer Sci. 2015 Sep;106(9):1232-9 Authors: Kawano S, Kojima M, Higuchi Y, Sugimoto M, Ikeda K, Sakuyama N, Takahashi S, Hayashi R, Ochiai A, Saito N Abstract Generally, cancer tissue is palpated as a hard mass. However, the elastic nature of cancer tissue is not well understood. The aim of the present study was to evaluate the clinical utility of measuring the el...περισσότερα »
SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
[image: http:--http://ift.tt/1feGv2I] Related Articles *SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma.* Oncogene. 2015 Sep 24;34(39):5055-68 Authors: Hernanda PY, Chen K, Das AM, Sideras K, Wang W, Li J, Cao W, Bots SJ, Kodach LL, de Man RA, Ijzermans JN, Janssen HL, Stubbs AP, Sprengers D, Bruno MJ, Metselaar HJ, ten Hagen TL, Kwekkeboom J, Peppelenbosch MP, Pan Q Abstract Further understanding of the molecular biology and pathogenesis of hepatocellular carcinoma (HCC) is crucial for future therapeutic development. SMAD4, recognized as an important tumor suppres... περισσότερα »
A Federated Network for Translational Cancer Research Using Clinical Data and Biospecimens.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*A Federated Network for Translational Cancer Research Using Clinical Data and Biospecimens.* Cancer Res. 2015 Dec 15;75(24):5194-5201 Authors: Jacobson RS, Becich MJ, Bollag RJ, Chavan G, Corrigan J, Dhir R, Feldman MD, Gaudioso C, Legowski E, Maihle NJ, Mitchell K, Murphy M, Sakthivel M, Tseytlin E, Weaver J Abstract Advances in cancer research and personalized medicine will require significant new bridging infrastructures, including more robust biorepositories that link human tissue to clinical phenotypes and outcomes. In order to meet that challenge, four cancer centers form... περισσότερα »
A role for the androgen receptor in the treatment of male breast cancer.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*A role for the androgen receptor in the treatment of male breast cancer.* Crit Rev Oncol Hematol. 2015 Nov 26; Authors: Zhu J, Davis CT, Silberman S, Spector N, Zhang T Abstract Male breast cancer (BC) is relatively rare, making up less than 1% of all breast cancer cases in the United States. Treatment guidelines for male BC are derived from studies on the treatment of female BC, and are based molecular and clinical characteristics, such as hormone receptor positivity. For female estrogen receptor positive (ER+) breast cancers, the standard of care includes three classes of endo... περισσότερα »
How to approach phyllodes tumors of the breast?
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*How to approach phyllodes tumors of the breast?* Ulus Cerrahi Derg. 2015;31(4):197-201 Authors: Acar T, Tarcan E, Hacıyanlı M, Kamer E, Peşkersoy M, Yiğit S, Gür Ö, Cin N, Sarı AA, Tatar F Abstract OBJECTIVE: Phyllodes tumor of the breast is a rare fibroepithelial breast tumor that comprise 0.3-0.9% of primary breast neoplasms. In this study, we aimed to present clinicopathologic symptoms of our patients along with their treatment modality. MATERIAL AND METHODS: Clinicopathologic properties and treatment modality of 20 phyllodes tumor patients who underwent surgery between Janua...περισσότερα »
Oral malignant melanoma: Report of three cases with literature review.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Oral malignant melanoma: Report of three cases with literature review.* Natl J Maxillofac Surg. 2015 Jan-Jun;6(1):103-9 Authors: Gupta S, Tandon A, Ram H, Gupta OP Abstract Primary oral melanoma is known to be an extremely rare and aggressive neoplasm arising from the mucosal epithelium of the oral cavity especially upper jaw (palate or alveolar gingivae). Malignant melanoma that does not originate in the skin is a very rare disease and is considered one of the most deadly of all human neoplasms. Oral malignant melanoma (OMM) represents about 1% of all melanomas and approximatel...περισσότερα »
Extrapleural Solitary Fibrous Tumor of the Foot A Case Report.
Alexandros G. SfakianakisστοHead and NeckΠριν από 4 δευτερόλεπτα
*Extrapleural Solitary Fibrous Tumor of the Foot A Case Report.* J Am Podiatr Med Assoc. 2015 Nov;105(6):557-9 Authors: Kean CA, Moore BR, Nettles AM, Bui RP Abstract Solitary fibrous tumors are uncommon mesenchymal neoplasms that were initially described as pleural tumors, but in recent years, numerous extrapleural sites have been reported. A solitary fibrous tumor is characterized as a circumscribed, painless mass with a patternless growth pattern, positive CD34 spindle-shaped cells, bcl-2, and dense keloidal collagen with areas of hypercellularity and hypocellularity. This cas... περισσότερα »
Biological inflammatory markers mediate the effect of preoperative pain-related behaviours on postoperative analgesics requirements
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
The predictive value of an individual’s attitude towards painful situations and the status of his immune system for postoperative analgesic requirements are not well understood. These may help the clinician to… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1k4uBKB via IFTTT
Codifying healthcare – big data and the issue of misclassification
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
The rise of electronic medical records has led to a proliferation of large observational studies that examine the perioperative period. In contrast to randomized controlled trials, these studies have the abili… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1NV10PI via IFTTT
Is tracheostomy a better choice than translaryngeal intubation for critically ill patients requiring mechanical ventilation for more than 14 days? A comparison of short-term outcomes
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Tracheostomy is recommended for patients receiving mechanical ventilation (MV) for 14 days or more in the intensive care unit (ICU). Nevertheless, many patients undergoing prolonged MV remain intubated via the… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1k4uBdC via IFTTT
Femoral nerve block-sciatic nerve block vs. femoral nerve block-local infiltration analgesia for total knee arthroplasty: a randomized controlled trial
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
The use of femoral nerve block (FNB) combined with sciatic nerve block (SNB) after total knee arthroplasty (TKA) has recently become controversial. Local infiltration analgesia (LIA) has been reported to be ef… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1k4uzlM via IFTTT
Retrospective evaluation of the effect of carotid artery stenosis on cerebral oxygen saturation during off-pump coronary artery bypasses grafting in adult patients
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
It is unknown whether cerebral oxygenation in patients with carotid artery stenosis (CAS) undergoing off-pump coronary artery bypass grafting (CABG) differs from that in patients without CAS. Thus, the effect … from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1NV0YaO via IFTTT
Newer cancer drug may help protect kidneys from damage caused by older drug https://t.co/SW2KrFefST
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Newer cancer drug may help protect kidneys from damage caused by older drug https://t.co/SW2KrFefST from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/677453978204921858 via IFTTT
Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Specificity protein (Sp) transcription factors play pivotal roles in maintaining the phenotypes of many cancers. We hypothesized that the antineoplastic effects of sulindac and its metabolites were due, in par… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1MiTOHF via IFTTT
Choroidal metastases from thymic carcinoma during pregnancy: Case Report
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Rare sites of metastases, atypical symptoms and paraneoplastic syndromes are often neglected or misinterpreted, especially when they represent early symptoms of an underlying malignant disease. Hence, an inter… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1IWgEKt via IFTTT
Cytokeratin 20 positive circulating tumor cells are a marker for response after neoadjuvant chemoradiation but not for prognosis in patients with rectal cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Several studies have shown, that circulating tumor cells (CTC) have a negative prognostic value in colorectal cancer patients. Aim of this study was to evaluate the role of CTC in specifically rectal cancer pa… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1MiTOrc via IFTTT
Prevalence of peri-implant disease
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 18 δευτερόλεπτα
Prevalence of peri-implant disease on platform switching implants: a cross-sectional pilot study: The objective of this study was to assess the prevalence of mucositis and peri-implantitis associated with the use of two types of implants—conventional versus platform switching after one year of loading. A longitudinal study of 64 implants in 25 patients was performed. Clinical …
Evaluation of toothbrush disinfection via different methods
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 18 δευτερόλεπτα
Evaluation of toothbrush disinfection via different methods: The aim of this study was to compare the efficacy of using a dishwasher or different chemical agents, including 0.12% chlorhexidine gluconate, 2% sodium hypochlorite (NaOCl), a mouthrinse containing essential oils and alcohol, and 50% white vinegar, for toothbrush disinfection. Sixty volunteers were divided into five experimental groups …
Interforaminal Mandible Region of Individuals With Pierre Robin Sequence and Treacher Collins Syndrome Through the Cone-Beam Computed Tomography.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 18 δευτερόλεπτα
Evaluation of Interforaminal Mandible Region of Individuals With Pierre Robin Sequence and Treacher Collins Syndrome Through the Cone-Beam Computed Tomography.: The Pierre Robin sequence (PRS) and the Treacher Collins syndrome (TCS) are conditions that cause significant abnormalities of jaw. This study was conducted in anticipation of evaluating the morphology of interforaminal region and identify the …
Patient-Specific Orbital Implants
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 18 δευτερόλεπτα
Patient-Specific Orbital Implants: Development and Implementation of Technology for More Accurate Orbital Reconstruction.: Fracture of the orbital floor is commonly seen in facial trauma. Accurate anatomical reconstruction of the orbital floor contour is challenging. The authors demonstrate a novel method to more precisely reconstruct the orbital floor on a 50-year-old female who sustained an orbital …
Lid Contour in Thyroid Eye Disease With Upper and Lower Eyelid Retraction Using Multiple Radial Midpupil Lid Distances.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 18 δευτερόλεπτα
Analysis of Lid Contour in Thyroid Eye Disease With Upper and Lower Eyelid Retraction Using Multiple Radial Midpupil Lid Distances.: Purpose: The aim of this study was to analyze upper and lower eyelid contours in adult patients with thyroid eye disease (TED) and normal adults using a software program that measures multiple radial midpupil lid …
Acknowledgement to Reviewers
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 18 δευτερόλεπτα
Psychopathology 2015;48:423-424 from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Ib0TPU via IFTTT
Percutaneous sclerotherapy of arteriovenous malformations of the face using fibrin glue combined with OK-432 and bleomycin after embolisation
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 18 δευτερόλεπτα
Percutaneous sclerotherapy of arteriovenous malformations of the face using fibrin glue combined with OK-432 and bleomycin after embolisation: Congenital arteriovenous malformations (AVM) in the maxillofacial region are rare, but potentially life-threatening, vascular lesions. Here we review our experience of 13 patients with AVM of the facial soft tissues who were treated using percutaneous sclerotherapy with …
Contents Vol. 48, 2015
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 18 δευτερόλεπτα
Psychopathology 2015;48:I-IV from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Ib0TPS via IFTTT
Temporalis Muscle During Cranioplasty With Titanium Mesh After Standard Trauma Craniectomy.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 18 δευτερόλεπτα
Effect of Reflection of Temporalis Muscle During Cranioplasty With Titanium Mesh After Standard Trauma Craniectomy.: Cranioplasty (CP) with titanium mesh after standard trauma craniectomy (STC) has been proven to be a favorable technology. According to reflection of temporalis muscle or not, the CP was divided into 2 operation ways. Effect of reflection of temporalis muscle …
New drug that protects dopamine cells raises treatment hope for Parkinson’s
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 18 δευτερόλεπτα
A mouse study shows how a novel drug can alter immune responses so they protect instead of attack dopamine-producing cells, loss of which leads to Parkinson’s disease. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1MiS15u via IFTTT
Modified Sistrunk operation: New concept for management of thyroglossal duct cyst.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 23 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Modified Sistrunk operation: New concept for management of thyroglossal duct cyst.* Int J Pediatr Otorhinolaryngol. 2015 Jun;79(6):812-6 Authors: Ryu YJ, Kim DW, Jeon HW, Chang H, Sung MW, Hah JH Abstract OBJECTIVE: To describe a method of hyoid cartilage division during Sistrunk operation for management of thyroglossal duct cyst (TGDC) and compare postoperative outcomes with those of conventional hyoid bone cutting. METHODS: Fifty-nine patients who received operative treatment for TGDC from January 2005 to July 2... περισσότερα »
The Ethics of Using the Recently Deceased to Instruct Residents in Cricothyrotomy.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 23 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *The Ethics of Using the Recently Deceased to Instruct Residents in Cricothyrotomy.* Ann Emerg Med. 2015 Oct;66(4):403-8 Authors: Makowski AL Abstract Cricothyrotomy is a rare but crucial procedure in the armamentarium of the emergency physician. The infrequency with which it is performed has led to a reliance on models, simulators, and animals in resident education, but each of these methods has unique drawbacks. Using recently deceased patients as teaching tools has a long history in medicine, though controvers...περισσότερα »
Otitis media in sperm-associated antigen 6 (Spag6)-deficient mice.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 23 δευτερόλεπτα
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Otitis media in sperm-associated antigen 6 (Spag6)-deficient mice.* PLoS One. 2014;9(11):e112879 Authors: Li X, Xu L, Li J, Li B, Bai X, Strauss JF, Zhang Z, Wang H Abstract Mammalian SPAG6 protein is localized to the axoneme central apparatus, and it is required for normal flagella and cilia motility. Recent studies demonstrated that the protein also regulates ciliogenesis and cilia polarity in the epithelial cells of brain ventricles and trachea. Motile cilia are also present in the ep... περισσότερα »
Correlation of the VEMP score, ambulation and upper extremity function in clinically isolated syndrome.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 23 δευτερόλεπτα
*Correlation of the VEMP score, ambulation and upper extremity function in clinically isolated syndrome.* J Neurol Sci. 2015 Dec 15;359(1-2):197-201 Authors: Crnošija L, Krbot Skorić M, Gabelić T, Adamec I, Brinar V, Habek M Abstract OBJECTIVE: To investigate the correlation of the vestibular evoked myogenic potential (VEMP) score with Timed 25-Foot Walk (T25FW), 9-Hole Peg Test (9HPT), Paced Auditory Serial Addition Test (PASAT) and EDSS in patients with multiple sclerosis (MS). METHODS: This prospective, cross sectional study included 52 patients with clinically isolated syndro...περισσότερα »
[Save the post-market cancer clinical trials in Japan--their benefit to society must not be forgotten].
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 23 δευτερόλεπτα
*[Save the post-market cancer clinical trials in Japan--their benefit to society must not be forgotten].* Gan To Kagaku Ryoho. 2015 Oct;42(10):1179-82 Authors: Saji S PMID: 26665418 [PubMed - in process] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1TRMbxu via IFTTT
Low prevalence of patients with mitochondrial disease in the German/Austrian DPV diabetes registry.
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
*Low prevalence of patients with mitochondrial disease in the German/Austrian DPV diabetes registry.* Eur J Pediatr. 2015 Dec 15; Authors: Reinauer C, Meissner T, Roden M, Thon A, Holterhus PM, Haberland H, Binder E, Marg W, Bollow E, Holl R Abstract The aim of this study was to characterize the phenotype and treatment of young patients (manifestation <30 years) with diabetes of mitochondrial origin (DMO), based on the German/Austrian DPV (Diabetes Patienten Verlaufsdokumentation) registry. Only 13 (0.02 %) of all patients with diabetes in this cohort were identified with DMO, ma...περισσότερα »
The evolutionarily conserved Tre2/Bub2/Cdc16 (TBC), Lysin motif (LysM), Domain catalytic (TLDc) domain is neuroprotective against oxidative stress.
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
*The evolutionarily conserved Tre2/Bub2/Cdc16 (TBC), Lysin motif (LysM), Domain catalytic (TLDc) domain is neuroprotective against oxidative stress.* J Biol Chem. 2015 Dec 14; Authors: Finelli MJ, Sanchez-Pulido L, Liu KX, Davies KE, Oliver PL Abstract Oxidative stress is a pathological feature of many neurological disorders, therefore utilizing proteins that are protective against such cellular insults is a potentially valuable therapeutic approach. Oxidation resistance 1 (OXR1) has been shown previously to be critical for oxidative stress resistance in neuronal cells; deletion o... περισσότερα »
Identification of Two Disease-causing Genes TJP2 and GJB2 in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment.
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
*Identification of Two Disease-causing Genes TJP2 and GJB2 in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment.* Chin Med J (Engl). 2015 20th Dec;128(24):3345-3351 Authors: Wang HY, Zhao YL, Liu Q, Yuan H, Gao Y, Lan L, Yu L, Wang DY, Guan J, Wang QJ Abstract BACKGROUND: There are more than 300 genetic loci that have been found to be related to hereditary hearing impairment (HHI), including 92 causative genes for nonsyndromic hearing loss, among which 34 genes are related to autosomal dominant nonsyndromic HHI (ADNSHHI). Traditiona... περισσότερα »
Whole exome sequencing identifies mutations in Usher syndrome genes in profoundly deaf Tunisian patients.
Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC]Related Articles *Whole exome sequencing identifies mutations in Usher syndrome genes in profoundly deaf Tunisian patients.* PLoS One. 2015;10(3):e0120584 Authors: Riahi Z, Bonnet C, Zainine R, Lahbib S, Bouyacoub Y, Bechraoui R, Marrakchi J, Hardelin JP, Louha M, Largueche L, Ben Yahia S, Kheirallah M, Elmatri L, Besbes G, Abdelhak S, Petit C Abstract Usher syndrome (USH) is an autosomal recessive disorder characterized by combined deafness-blindness. It accounts for about 50% of all hereditary deafness bl...περισσότερα »
Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Specificity protein (Sp) transcription factors play pivotal roles in maintaining the phenotypes of many cancers. We hypothesized that the antineoplastic effects of sulindac and its metabolites were due, in par… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1MiTOHF via IFTTT
Choroidal metastases from thymic carcinoma during pregnancy: Case Report
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Rare sites of metastases, atypical symptoms and paraneoplastic syndromes are often neglected or misinterpreted, especially when they represent early symptoms of an underlying malignant disease. Hence, an inter… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1IWgEKt via IFTTT
Cytokeratin 20 positive circulating tumor cells are a marker for response after neoadjuvant chemoradiation but not for prognosis in patients with rectal cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Several studies have shown, that circulating tumor cells (CTC) have a negative prognostic value in colorectal cancer patients. Aim of this study was to evaluate the role of CTC in specifically rectal cancer pa… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1MiTOrc via IFTTT
Evaluation of KIF23 variant 1 expression and relevance as a novel prognostic factor in patients with hepatocellular carcinoma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
KIF23 (kinesin family member 23) is a kinesin-like motor protein and plays an important role in cytokinesis. In search for genes associated with hepatocellular carcinoma (HCC) by cDNA microarray, we found that… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1MiTMzK via IFTTT
Methylation status of COX-2 in blood leukocyte DNA and risk of gastric cancer in a high-risk Chinese population
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Methylation is a common epigenetic modification which may play a crucial role in cancer development. To investigate the association between methylation of COX-2 in blood leukocyte DNA and risk of gastric cancer (… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1MiTh8B via IFTTT
Long-term outcomes in medial flap inferior turbinoplasty are superior to submucosal electrocautery and submucosal powered turbinate reduction
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Background Techniques for inferior turbinate reduction vary from complete turbinectomy to limited cauterization. Surgical methods differ on the degree of tissue reduction and reliance on surgical tissue removal vs tissue ablation. The outcome and morbidity from 3 different turbinate techniques are compared. Methods A randomized double-blinded study was performed. Patient nasal cavities were randomized to […]
Prevalence of confirmed asthma varies in chronic rhinosinusitis subtypes
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Background Chronic rhinosinusitis (CRS) and asthma describe inflammation of the upper and lower airway, respectively. Not surprisingly, the prevalence of CRS and asthma has been linked, with up to 50% asthma prevalence in CRS with nasal polyposis (CRSwNP) patients. However, these prevalence rates do not address subtypes of CRSwNP including allergic fungal rhinosinusitis (AFRS). This […]
T2R38 genotype is correlated with sinonasal quality of life in homozygous ΔF508 cystic fibrosis patients
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Background Chronic rhinosinusitis (CRS) is very prevalent in the cystic fibrosis (CF) patient population, and leads to high morbidity and markedly decreased quality of life (QOL). Identification of genetic markers that contribute to CRS symptoms in these patients can allow for risk stratification and tailoring of medical and surgical treatments. T2R38 is a bitter taste […]
Olfactory-specific quality of life outcomes after endoscopic sinus surgery
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Background Olfactory loss is a cardinal symptom of chronic rhinosinusitis (CRS) and affects 40% to 80% of patients. However, common sinus-specific quality-of-life (QOL) instruments include only single questions related to olfaction. Few studies have explored olfactory outcomes after surgery utilizing validated, olfaction-specific QOL questionnaires. Methods Patients with CRS were enrolled from 3 centers across North […]
Fighting sinus-derived Staphylococcus aureus biofilms in vitro with a bacteriophage-derived muralytic enzyme
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
Background Staphylococcus aureus biofilms are a nidus for exacerbation of infectious conditions including chronic rhinosinusitis (CRS). Resistance of biofilms to current therapeutics stresses the need for the development of novel anti-biofilm strategies. The chimeric muralytic enzyme P128 was specifically engineered to target Staphylococcal sp. by combining the cell wall binding domain of lysostaphin and the […]
Eggshell-Derived Hydroxyapatite in Bone Regeneration.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Eggshell-Derived Hydroxyapatite: A New Era in Bone Regeneration.: Background: Defects of maxillofacial skeleton lead to personal (functional and aesthetic), social and behavioral problems; which make the person to isolate from the main stream of society. So, bone regeneration is the need for proper structure, function, and aesthetics following cyst enucleation, trauma, and tumor ablative surgery; which helps for overall health of the individual. Aim and Objectives: The preliminary study is planned to evaluate and compare the efficacy of eggshell-derived hydroxyapatite (EHA) and synth... περισσότερα »
Low Grade Fibromyxoid Sarcoma in Oral Cavity: A Rare Case Report
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Low Grade Fibromyxoid Sarcoma in Oral Cavity: A Rare Case Report: AbstractLow-grade fibromyxoid sarcoma (LGFMS) is a rare, low-grade malignant soft tissue neoplasm. It is a distinctive variant of fibrosarcoma with a high metastasizing potential and sometimes long interval between tumor presentation and metastasis. It may present in any part of body. However in the region of the head and neck, they are seldom seen and hence easily misdiagnosed. We report the case of an 18-year-old female who developed a large mass in the left oral cavity. The tumor was excised. On pathology evaluati...περισσότερα »
Challenges in the Management of Laryngeal Stenosis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Challenges in the Management of Laryngeal Stenosis: AbstractLaryngeal stenosis is one of the most complex and challenging problems in the field of head and neck surgery. The management involves a multidisciplinary approach with multiple complex procedures. In this study we discuss our experience of laryngeal stenosis with regards to patient characteristics, cause and management. A retrospective analysis of 35 patients of laryngeal stenosis treated at a tertiary care centre was evaluated. Inclusion criteria were all patients with laryngeal stenosis who required surgical intervention...περισσότερα »
Extracranial Head and Neck Schwannomas
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Extracranial Head and Neck Schwannomas: Our Experience: AbstractSchwannomas are benign neoplasms of the peripheral nerves originating in the Schwann cells. They are rare and usually solitary, with clearly delimited capsules. They occur in the head and neck region in only 25 % of the cases, and may be associated with Von Recklinghausen’s disease. Schwannomas are always a diagnostic dilemma as they are asymptomatic for long time and histopathology is the gold standard for diagnosis. The present study retrospectively analysed data of 4 patients with schwannomas and reviewed the litera... περισσότερα »
The Alloplastic Ossicular Prosthesis Materials
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Results of Hearing Outcome According to the Alloplastic Ossicular Prosthesis Materials: AbstractThe aim of this study is to compare the functional results and extrusion rates according to the type of ossciular alloplastic prosthesis. In this study, a retrospective analysis was performed. Sixty-one patients were involved in partial ossicular replacement (POR) cases and 70 patients were involved in total osscicular replacement (TOR) cases. In POR cases, Plastipore was used in 21 cases, hydroxyapatite in 20 cases, and titanium in 20 cases. In TOR cases, Plastipore was used in 20 cases... περισσότερα »
Früherkennung kanzeröser Läsionen in Oropharynx und Mundhöhle
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Früherkennung kanzeröser Läsionen in Oropharynx und Mundhöhle: Zusammenfassung HintergrundFrüherkennung von kanzerösen Läsionen ist nach wie vor entscheidend für die Prognose des Patienten. Dabei stellt sich der diagnostische Zugang zu Mundhöhle und Oropharynx vergleichsweise unproblematisch dar. Dennoch ist die Inzidenz unverändert hoch, da die Läsionen rein visuell in vielen Fällen zu spät als maligne erkannt werden. Das hyperspektrale Imaging wurde bereits im Larynx als mögliche Untersuchungsmethode zur Früherkennung präkanzeröser und kanzeröser Veränderungen beschrieben. Hier ... περισσότερα »
Kopfschmerzen
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Kopfschmerzen: ZusammenfassungKopfschmerz ist das Leitsymptom vieler Krankheitsbilder, unter denen HNO-spezifische Erkrankungen selten sind, was sich aber nicht in der Anzahl der konsultierenden Patienten widerspiegelt. Die Kenntnis der Merkmale häufig vorkommender primärer Kopfschmerzformen ist für den HNO-Arzt essenziell, da er unter verhältnismäßig vielen Patienten die wenigen mit HNO-Ursachen herausfinden muss. Anlass zur Verwechslung von primären Kopfschmerzen mit z. B. einer Sinusitis sind die durch den N. trigeminus vermittelten Symptome wie nasale Obstruktion und Sekretion....περισσότερα »
Münsteraner Elternprogramm – Elternfeedback
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Münsteraner Elternprogramm – Elternfeedback: Zusammenfassung HintergrundNach der Einführung des Universellen Neugeborenen-Hörscreenings (UNHS) ist eine Anpassung der Frühförderkonzepte an die Situation und Bedürfnisse von Familien mit einem Säugling mit Hörschädigung notwendig. Das *Münsteraner Elternprogramm zur Kommunikationsförderung von Säuglingen und Kleinkindern mit Hörschädigung* (MEP) erfüllt diese Anforderung als Modul einer frühen und familienzentrierten Intervention. ZieleFragebogenbasiert wurde die Zufriedenheit der Eltern mit Vorgehen und Ergebnis des Programms erh... περισσότερα »
Prognostic impact of lymph node micrometastasis in oral and oropharyngeal squamous cell carcinomas
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Prognostic impact of lymph node micrometastasis in oral and oropharyngeal squamous cell carcinomas: Abstract Background The purpose of this study was to determine the role of lymph node micrometastasis in oral and oropharyngeal cancers. Methods We investigated the presence of micrometastases by cytokeratin immunohistochemical staining in 54 patients with node-negative oral and oropharyngeal carcinomas. Results The positive rate of cytokeratin expression was 13.0% (7 of 54 patients). The incidence of micrometastasis was significantly higher in patients with more invasive tumors (*p* ... περισσότερα »
Sinonasal mucosal melanoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Sinonasal mucosal melanoma: A 12-year experience of 58 cases: Abstract Background Sinonasal mucosal melanoma is a rare malignancy with poor prognosis. Methods Patients with sinonasal malignant melanoma who underwent surgery by different approaches were included in this study. Overall survival (OS) and event-free survival were calculated, and statistically significant variables by univariate analysis were entered in a multivariate Cox regression model. Results Pathological staging was pT3, pT4a, and pT4b in 30 cases (51.7%), 17 cases (29.3%), and 11 cases (19.0%). At 3 and 5 years, OS... περισσότερα »
Use of propranolol for parotid hemangioma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Use of propranolol for parotid hemangioma: Abstract Background Few specific reports have addressed propranolol as a treatment for parotid hemangioma, and its mechanism remains unclear. Methods Eighty-seven patients were recruited in this prospective study. Ten patients underwent detailed color Doppler examination. The depths, vessel densities, and resistant indices of 10 lesions were recorded and analyzed before treatment and at 1 and 3 months after treatment. Results The overall responses were “bad” in 2 cases, “stable” in 4 cases, “good” in 53 cases, and “excellent” in 28 cases. He...περισσότερα »
External validation of sTWEAK as a prognostic noninvasive biomarker for head and neck squamous cell carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
External validation of sTWEAK as a prognostic noninvasive biomarker for head and neck squamous cell carcinoma: Abstract Background The main purpose of this study was to validate the prognostic significance of tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) in head and neck squamous cell carcinoma (HNSCC) using an independent cohort. Methods Data were evaluated from 153 patients with HNSCC in stages III to IV, who received radiotherapy (RT) or chemoradiotherapy. We quantified soluble TWEAK (sTWEAK) in pretreatment samples using enzyme-linked immunosorbent assay. Re... περισσότερα »
Psychometric functions for sentence recognition in sinusoidally amplitude-modulated noises
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Psychometric functions for sentence recognition in sinusoidally amplitude-modulated noises: Listeners' speech reception is better when speech is masked by a modulated masker compared to an unmodulated masker with the same long-term root-mean-square level. It has been suggested that listeners take advantage of brief periods of quiescence in a modulated masker to extract speech information. Two experiments examined the contribution of such “dip-listening” models. The first experiment estimated psychometric functions for speech intelligibility using sentences masked by sinusoidally m...περισσότερα »
Procedures for ambient-pressure and tympanometric tests of aural acoustic reflectance and admittance in human infants and adults
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Procedures for ambient-pressure and tympanometric tests of aural acoustic reflectance and admittance in human infants and adults: Procedures are described to measure acoustic reflectance and admittance in human adult and infant ears at frequencies from 0.2 to 8 kHz. Transfer functions were measured at ambient pressure in the ear canal, and as down- or up-swept tympanograms. Acoustically estimated ear-canal area was used to calculate ear reflectance, which was parameterized by absorbance and group delay over all frequencies (and pressures), with substantial data reduction for tympan... περισσότερα »
Psychometric functions for sentence recognition in sinusoidally amplitude-modulated noises
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Psychometric functions for sentence recognition in sinusoidally amplitude-modulated noises: Listeners' speech reception is better when speech is masked by a modulated masker compared to an unmodulated masker with the same long-term root-mean-square level. It has been suggested that listeners take advantage of brief periods of quiescence in a modulated masker to extract speech information. Two experiments examined the contribution of such “dip-listening” models. The first experiment estimated psychometric functions for speech intelligibility using sentences masked by sinusoidally m...περισσότερα »
Procedures for ambient-pressure and tympanometric tests of aural acoustic reflectance and admittance in human infants and adults
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Procedures for ambient-pressure and tympanometric tests of aural acoustic reflectance and admittance in human infants and adults: Procedures are described to measure acoustic reflectance and admittance in human adult and infant ears at frequencies from 0.2 to 8 kHz. Transfer functions were measured at ambient pressure in the ear canal, and as down- or up-swept tympanograms. Acoustically estimated ear-canal area was used to calculate ear reflectance, which was parameterized by absorbance and group delay over all frequencies (and pressures), with substantial data reduction for tympan... περισσότερα »
Back-up procedures following complicated gastric pull-up procedure for esophageal reconstruction: Salvage with intestinal flaps
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 37 δευτερόλεπτα
Background Gastric pull-up (GPU) is the most common procedure for restoring the continuity of the alimentary tract. Yet, complications because of anastomotic problems are reported to be as high as 25% after this procedure. Managing the neck with anastomotic leakage or stricture following failed GPU and/or radiotherapy is formidable. We report our method, basic algorithm and results with the complicated GPU procedure management with intestinal transfers . Patients and methods Nineteen cases referred to our department with complicated esophageal reconstruction following GPU proced...περισσότερα »
Detecting number processing and mental calculation in patients with disorders of consciousness using a hybrid brain-computer interface system
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 37 δευτερόλεπτα
For patients with disorders of consciousness such as coma, a vegetative state or a minimally conscious state, one challenge is to detect and assess the residual cognitive functions in their brains. Number proc... from Neurology via xlomafota13 on Inoreader http://ift.tt/1JdO7en via IFTTT
Impact of omalizumab therapy on medication requirements for chronic rhinosinusitis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
Background Omalizumab is indicated for treatment of patients with moderate to severe allergic asthma. Previous studies have shown 70% of these patients also have chronic rhinosinusitis (CRS). The present series examines the impact of omalizumab on medication use for CRS in a cohort of asthmatic CRS patients who received this therapy. Methods The sample included […]
Comparison of intranasal fluticasone spray, budesonide atomizer, and budesonide respules in patients with chronic rhinosinusitis with polyposis after endoscopic sinus surgery
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
Background Nasal steroids are a critical part of the management of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) after endoscopic sinus surgery (ESS). Increasingly, practitioners are using budesonide respules delivered to the sinonasal cavities, which is an off-label use, in lieu of traditional nasal steroids. There has been little research comparing budesonide with traditional […]
The probability of readmission within 30 days of hospital discharge is positively associated with inpatient bed occupancy at discharge – a retrospective cohort study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
Previous work has suggested that given a hospital’s need to admit more patients from the emergency department (ED), high inpatient bed occupancy may encourage premature hospital discharges that favor the hospi… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1MiTKYs via IFTTT
A majority of rural emergency departments in the province of Quebec use point-of-care ultrasound: a cross-sectional survey
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
Point-of-care ultrasound (POCUS) can be used to provide rapid answers to specific and potentially life-threatening clinical questions, and to improve the safety of procedures. The rate of POCUS access and use … from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1IWgC5s via IFTTT
Emergency medical services transport delays for suspected stroke and myocardial infarction patients
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
Prehospital delays in receiving emergency care for suspected stroke and myocardial infarction (MI) patients have significant impacts on health outcomes. Use of Emergency Medical Services (EMS) has been shown t… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1IWgzGF via IFTTT
Adding physical therapy services in the emergency department to prevent immobilization syndrome – a feasibility study in a university hospital
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
The association between the functional decline occurring with bedrest and hospitalization in older persons is well-known. A long wait in the emergency department (ED), where patients can be bedridden, is a ris… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1MiTJUk via IFTTT
Physicians’ use of pain scale and treatment procedures among children and youth in emergency primary care – a cross sectional study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
Pain is a common symptom in children and youth attending casualty centres and emergency departments. The aim of this study was to acquire more knowledge about how pain in children is measured and handled by em… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1lSCq81 via IFTTT
A cutaneous presentation of a common condition
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
A 25 year old woman was reviewed on the ward by the dermatology team for persistent, painful intertriginous skin erosions beneath both breasts and in both groins. She had been admitted over a month… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Qrhgup via IFTTT
Cover story: call to action figures
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
John Burscough with his collection of over 300 toys, models, and action figures of doctors, begun after the purchase of a model of Mickey Mouse dressed as a doctor on a family trip to… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Nr8ngx via IFTTT
A cutaneous presentation of a common condition
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 46 δευτερόλεπτα
A 25 year old woman was reviewed on the ward by the dermatology team for persistent, painful intertriginous skin erosions beneath both breasts and in both groins. She had been admitted over a month… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Qrhgup via IFTTT
Comparing Hospitals and Health Prices and Volumes Across Countries: A New Approach
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Health services are among the most comparison-resistant services in international comparisons such as the Eurostat–OECD Purchasing Power Parities (PPP) program and the ICP. Traditionally, PPPs for health services are estimated on the basis of input methods, e.g. by comparing salaries of doctors and nurses. This mainly reflects the difficulties inherent in measuring the output […]
Comment Screening to improve ovarian cancer prognosis?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Despite increasingly radical surgical approaches and the huge efforts put into new and targeted therapeutic agents, prognosis for patients with ovarian cancer has hardly improved in the past three decades.1 Besides aiming to revolutionise treatment further, efforts need to focus on early detection of disease. In The Lancet, Ian Jacobs and colleagues2 report the results […]
Articles Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Although the mortality reduction was not significant in the primary analysis, we noted a significant mortality reduction with MMS when prevalent cases were excluded. We noted encouraging evidence of a mortality reduction in years 7–14, but further follow-up is needed before firm conclusions can be reached on the efficacy and cost-effectiveness of ovarian cancer screening. […]
Senkt Stillen das Risiko für Typ-2-Diabetes?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Gestationsdiabetes Nach einem Gestationsdiabetes ist intensives Stillen mit einem verringerten Risiko für Typ-2-Diabetes assoziiert. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NUWb92 via IFTTT
Von der Scham- zur Schuldkultur
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Transkulturelle Psychiatrie In unserer individualistischen Gesellschaft sind Schamgefühle teilweise verloren gegangen. Wir tun uns daher schwer im Umgang mit Kulturen, in denen die Ehre eine wichtige Rolle spielt. Das kann auch die Arbeit in der Psychiatrie beeinträchtigen. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Nz6CeZ via IFTTT
Effects of Different Blood Glucose Levels on Critically Ill Patients in an Intensive Care Unit
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Aims: We explore the infection incidence and possible prognostic outcome relevance for patients with different blood glucose levels in an intensive care unit (ICU). Methods: A total of 98 cases were enrolled and divided into three groups based on average fasting blood glucose levels (group A: ≤6.1 mmol/l; group B: 6.1-10 mmol/l; group C: ≥10 […]
Role of Glucocorticoids in Cystic Ovarian Disease: Expression of Glucocorticoid Receptor in the Bovine Ovary
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The aim of this study was to characterize the expression of glucocorticoid receptor (GR) in the components of normal bovine ovary and in animals with cystic ovarian disease (COD). Changes in the protein and mRNA expression levels were determined in control cows and cows with COD by immunohistochemistry and real-time PCR. GR protein expression in […]
Overvaluation of shape and weight in adolescents with anorexia nervosa: does shape concern or weight concern matter more for treatment outcome?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Overvaluation of shape and weight is a key diagnostic feature of anorexia nervosa (AN); however, limited research has evaluated the clinical utility of differentiating between weight versus shape concerns. Understanding differences in these constructs may have important implications for AN treatment given the focus on weight regain. This study examined differences in treatment […]
Treatment of Non-Colorectal Liver Metastases
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Viszeralmedizin 2015;31:386 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NUWaC6 via IFTTT
Complex Rearrangement Involving Three Chromosomes, Four Breakpoints and a 2.7-Mb Deletion in the 18q Segment Observed in a Girl with Mild Learning Difficulties
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Complex chromosomal rearrangements (CCRs) are balanced or unbalanced structural rearrangements involving 3 or more cytogenetic break events on 2 or more different chromosomes. Here, we report a 7-year-old girl referred to our unit because of mild dysmorphic facial features, mild learning difficulties together with very mild mental retardation. Standard cytogenetic banding analysis revealed a de […]
Case 39-2015: A 22-Year-Old Man with Hypoxemia and Shock
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Presentation of Case. Dr. Peggy S. Lai: A 22-year-old man was admitted to the intensive care unit of this hospital in the winter because of hypoxemia and shock. The patient had been well until 5 days before admission, when head congestion, subjective fever, chills, and a nonproductive wet cough… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader […]
Laparoscopic alternatives to fundoplication for gastroesophageal reflux: the role of magnetic augmentation and electrical stimulation of the lower esophageal sphincter
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Reflux symptoms are very common, and despite modern medication they are a major cause of disease burden and loss of quality of life worldwide. Laparoscopic anti-reflux surgery is the only current effective alternative but suffers from the risks of long-term side effects. Surgery also suffers variation in standards and outcomes. Magnetic augmentation and electrical […]
Standardized data collection to build prediction models in oncology: a prototype for rectal cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1O8m0yj via IFTTT
‘Homing’ treatment could aid recovery for brain damaged patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Cardiff University scientists believe they may have found a way to aid recovery and minimise the risk of life-threatening infections in patients with traumatic brain injuries. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/229KYYp via IFTTT
Low Noncytotoxic Concentrations of 5-Fluorouracil Have No Adverse Effects on Maturation and Function of Bone Marrow-Derived Dendritic Cells in vitro: A Potentially Safe Adjuvant for Dendritic Cell-Based Cancer Therapy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background: Low, noncytotoxic concentrations of various chemotherapeutic drugs like 5-fluorouracil (5-FU) induce antitumor immune responses by selectively depleting tumor-induced immunosuppressive cells, and could therefore be used in combination with dendritic cell (DC) vaccines in order to enhance their immunotherapeutic efficacy. However, the likely negative influences of low, noncytotoxic doses of 5-FU on bone marrow-derived (BM)-DCs […]
Issue information – table of contents
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Rquck3 via IFTTT
Noninvasive Tests for Inflammatory Bowel Disease: A Meta-analysis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
BACKGROUND: The clinical presentation of pediatric inflammatory bowel disease (IBD) is often nonspecific and overlaps with functional gastrointestinal disorders. OBJECTIVE: To determine the diagnostic accuracy of symptoms, signs, noninvasive tests, and test combinations that can assist the clinician with the diagnosis of IBD in symptomatic children. METHODS: A literature search was conducted of Medline and […]
[III. Repeat pancreatectomy for recurrent pancreatic cancer].
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*[III. Repeat pancreatectomy for recurrent pancreatic cancer].* Gan To Kagaku Ryoho. 2015 Oct;42(10):1173-7 Authors: Yoshitomi H, Shimizu H, Ohtsuka M, Kato A, Furukawa K, Takayashiki T, Kuboki S, Takano S, Suzuki D, Sakai N, Kagawa S, Nojima H, Miyazaki M PMID: 26665417 [PubMed - in process] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1TRMdp6 via IFTTT
[II. Liver resection for recurrence of metastatic liver tumor following primary intervention with special reference to colorectal liver metastasis].
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*[II. Liver resection for recurrence of metastatic liver tumor following primary intervention with special reference to colorectal liver metastasis].* Gan To Kagaku Ryoho. 2015 Oct;42(10):1169-72 Authors: Kawaguchi Y, Hasegawa K, Kokudo N PMID: 26665416 [PubMed - in process] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1TRMd8Q via IFTTT
[I. Repeat hepatectomy for recurrent hepatocellular carcinoma--review of literature].
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*[I. Repeat hepatectomy for recurrent hepatocellular carcinoma--review of literature].* Gan To Kagaku Ryoho. 2015 Oct;42(10):1164-8 Authors: Ariizumi S, Katagiri S, Yamamoto M PMID: 26665415 [PubMed - in process] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1TRMd8M via IFTTT
[Re-surgical resection for the recurrence after initial surgical resection in HPB malignancies].
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*[Re-surgical resection for the recurrence after initial surgical resection in HPB malignancies].* Gan To Kagaku Ryoho. 2015 Oct;42(10):1162-3 Authors: Miyazaki M PMID: 26665414 [PubMed - in process] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1TRMbh6 via IFTTT
[Definition of inflammatory subtypes of chronic rhinosinusitis with nasal polyp and asthma].
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*[Definition of inflammatory subtypes of chronic rhinosinusitis with nasal polyp and asthma].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Aug;29(16):1495-500 Authors: Wu D, Zhang M, Song Q Abstract Chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma is a common clinical refractory airway disease. Comprehensive treatment of nasal endoscopic surgery including nasal endoscopic surgery and medication, which can significantly improve nose-pulmonary symptoms and make sinusitis and asthma easier to be controlled by medication, has certain superiority. But the existen...περισσότερα »
[Nasal cavity supernumerary tooth and maxillary sinusitis: one case reported].
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*[Nasal cavity supernumerary tooth and maxillary sinusitis: one case reported].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Aug;29(16):1494-5 Authors: Guo G, Hu L, Lu Y Abstract Supernumerary tooth is a rare case. This report described a case of nasal cavity supernumerary tooth association with maxillary sinusitis. A 28-year-old male patient reported with the chief complaint of nasal obstruction, headache and purulent secretion for the past three months. Clinic examination and CT examination showed that there was a supernumerary tooth in the right nasal bottom, and max...περισσότερα »
[Giant ossifying fibroma of nasal cavity and nasal sinuses: one case report].
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*[Giant ossifying fibroma of nasal cavity and nasal sinuses: one case report].* Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Aug;29(16):1492-3 Authors: Tu X, Chen J, Jiang H Abstract A 39 years old male patient was admitted with the right of facial abnormalities and gradually protruding in right eye more than 30 years. CT shows high mixed density, clear boundary, and the right eye was crowded to the right. Giant tumor had completely been excised, and the result was fine. The outline figure and function of patients were obviously improved. The pathological examination aft... περισσότερα »
Sensors, Vol. 15, Pages 31859-31868: Localization of Mixed Completely and Partially Polarized Signals with Crossed-Dipole Sensor Arrays
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
In this paper, we investigate the problem of source localization and classification under the coexistence of both completely polarized (CP) and partially polarized (PP) electromagnetic (EM) signals, using a crossed-dipole sensor array. We propose a MUltiple SIgnal Classification (MUSIC)-based solution, which does not require multidimensional searches. Moreover, the proposed method need no estimation of the degree of polarization of signals. The efficacy of the proposed method is examined by comparing with existing methods. from #Medicine via ola Kala on Inoreader http://ift.tt/1Pa... περισσότερα »
Sensors, Vol. 15, Pages 31843-31858: A Security Assessment Mechanism for Software-Defined Networking-Based Mobile Networks
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Software-Defined Networking-based Mobile Networks (SDN-MNs) are considered the future of 5G mobile network architecture. With the evolving cyber-attack threat, security assessments need to be performed in the network management. Due to the distinctive features of SDN-MNs, such as their dynamic nature and complexity, traditional network security assessment methodologies cannot be applied directly to SDN-MNs, and a novel security assessment methodology is needed. In this paper, an effective security assessment mechanism based on attack graphs and an Analytic Hierarchy Process (AHP) ... περισσότερα »
Biogeographic variation in the microbiome of the ecologically important sponge, Carteriospongia foliascens
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Sponges are well known for hosting dense and diverse microbial communities, but how these associations vary with biogeography and environment is less clear. Here we compared the microbiome of an ecologically important sponge species, Carteriospongia foliascens, over a large geographic area and identified environmental factors likely responsible for driving microbial community differences between inshore and offshore locations using co-occurrence networks (NWs). The microbiome of C. foliascens exhibited exceptionally high microbial richness, with more than 9,000 OTUs identified at ...περισσότερα »
A Human IgG-like Bispecific Antibody Co-targeting Epidermal Growth Factor Receptor and the Vascular Endothelial Growth Factor Receptor 2 for Enhanced Antitumor Activity.
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 1 ώρα
*A Human IgG-like Bispecific Antibody Co-targeting Epidermal Growth Factor Receptor and the Vascular Endothelial Growth Factor Receptor 2 for Enhanced Antitumor Activity.* Cancer Biol Ther. 2015 Dec 15;:0 Authors: Chen Z, Xie W, Acheampong DO, Xu M, He H, Yang M, Li C, Luo C, Wang M, Zhang J Abstract Both Epidermal Growth Factor Receptor (EGFR) and the Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) play critical roles in tumorigenesis. We hypothesized co-targeting EGFR and VEGFR2 using a bispecific antibody might have significant therapeutic potential. Here,we designed a... περισσότερα »
Role of Glucocorticoids in Cystic Ovarian Disease: Expression of Glucocorticoid Receptor in the Bovine Ovary
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
The aim of this study was to characterize the expression of glucocorticoid receptor (GR) in the components of normal bovine ovary and in animals with cystic ovarian disease (COD). Changes in the protein and mRNA expression levels were determined in control cows and cows with COD by immunohistochemistry and real-time PCR. GR protein expression in granulosa cells was higher in cysts from animals with spontaneous COD and adrenocorticotropic hormone-induced COD than in tertiary follicles from control animals. In theca interna cells, GR expression was higher in cysts from animals with ...περισσότερα »
Feasibility of progressive sit-to-stand training among older hospitalized patients
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Background. In older patients, hospitalization is associated with a decline in functional performance and loss of muscle strength. Loss of muscle strength and functional performance can be prevented by systematic strength training, but details are lacking regarding the optimal exercise program and dose for older patients. Therefore, our aim was to test the feasibility of a progression model for loaded sit-to-stand training among older hospitalized patients.Methods. This is a prospective cohort study conducted as a feasibility study prior to a full-scale trial. We included twenty-fo... περισσότερα »
Differential scanning calorimetry of whole Escherichia coli treated with the antimicrobial peptide MSI-78 indicate a multi-hit mechanism with ribosomes as a novel target
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Differential Scanning Calorimetry (DSC) of intact Escherichia coli (E. coli) was used to identify non-lipidic targets of the antimicrobial peptide (AMP) MSI-78. The DSC thermograms revealed that, in addition to its known lytic properties, MSI-78 also has a striking effect on ribosomes. MSI-78's effect on DSC scans of bacteria was similar to that of kanamycin, an antibiotic drug known to target the 30S small ribosomal subunit. An in vitro transcription/translation assay helped confirm MSI-78's targeting of ribosomes. The scrambled version of MSI-78 also affected the ribosome peak o... περισσότερα »
2015 Middle East Respiratory Syndrome Coronavirus (MERS-CoV) nosocomial outbreak in South Korea: insights from modeling
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Background. Since the emergence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in 2012, more than 1,300 laboratory confirmed cases of MERS-CoV infections have been reported in Asia, North Africa, and Europe by July 2015. The recent MERS-CoV nosocomial outbreak in South Korea quickly became the second largest such outbreak with 186 total cases and 36 deaths in a little more than one month, second only to Saudi Arabia in country-specific number of reported cases.Methods. We use a simple mathematical model, the Richards model, to trace the temporal course of the South Kor... περισσότερα »
Absence of Benefit of Transcatheter Arterial Chemoembolization (TACE) in Patients with Resectable Solitary Hepatocellular Carcinoma.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Absence of Benefit of Transcatheter Arterial Chemoembolization (TACE) in Patients with Resectable Solitary Hepatocellular Carcinoma.* World J Surg. 2015 Dec 14; Authors: Ha TY, Hwang S, Lee YJ, Kim KH, Ko GY, Ii Gwon D, Ahn CS, Moon DB, Song GW, Jung DH, Lee HC, Lim YS, Kim KM, Shim JH, Choi JH, Lee SG Abstract BACKGROUND: This study aimed to assess the prognostic impact of preoperative transcatheter arterial chemoembolization (TACE) on long-term survival outcomes in patients undergoing resection of small solitary hepatocellular carcinoma (HCC). METHODS: Enrolled patients had un... περισσότερα »
Associations of Body Mass Index with Incident Fractures and Hip Structural Parameters in a Large Canadian Cohort.
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Associations of Body Mass Index with Incident Fractures and Hip Structural Parameters in a Large Canadian Cohort.* J Clin Endocrinol Metab. 2015 Dec 15;:jc20153123 Authors: Shen J, Leslie WD, Nielson CM, Majumdar SR, Morin SN, Orwoll ES Abstract CONTEXT: Fractures in obese individuals are of public health importance, but the relationship between obesity and fracture is complex and remains poorly understood. OBJECTIVE: The study examined the association of BMI with bone structural and strength parameters and incident fracture. DESIGN AND SETTING: We performed cross-sectional and l...περισσότερα »
Circulating Sex Hormones and Risk of Uterine Fibroids: Study of Women's Health Across the Nation (SWAN).
Alexandros G. SfakianakisστοHead and NeckΠριν από 1 ώρα
*Circulating Sex Hormones and Risk of Uterine Fibroids: Study of Women's Health Across the Nation (SWAN).* J Clin Endocrinol Metab. 2015 Dec 15;:jc20152935 Authors: Wong JY, Gold EB, Johnson WO, Lee JS Abstract CONTEXT: Estrogen has been implicated in the development of uterine fibroids. However, the contribution of androgen in women is unknown. OBJECTIVE: Our objective was to assess the longitudinal relations of circulating androgens and estradiol (E2) and their joint effects to the risk of developing fibroids. DESIGN: This is a 13-year longitudinal study in the Study of Women's ... περισσότερα »
Role of Glucocorticoids in Cystic Ovarian Disease: Expression of Glucocorticoid Receptor in the Bovine Ovary
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
The aim of this study was to characterize the expression of glucocorticoid receptor (GR) in the components of normal bovine ovary and in animals with cystic ovarian disease (COD). Changes in the protein and mRNA expression levels were determined in control cows and cows with COD by immunohistochemistry and real-time PCR. GR protein expression in granulosa cells was higher in cysts from animals with spontaneous COD and adrenocorticotropic hormone-induced COD than in tertiary follicles from control animals. In theca interna cells, GR expression was higher in cysts from animals with ...περισσότερα »
Moria Revisited: Translation of Moritz Jastrowitz’s Description of Pathologic … – Psychiatric News
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Moria Revisited: Translation of Moritz Jastrowitz’s Description of Pathologic … Psychiatric News He went on to describe a further 12 cases of “the so-called moria,” proposing that it was not exclusively seen in brain tumors but could occur in other diseases affecting the frontal lobes. Moria or pathologic … Although Jastrowitz described them … from …
Another 18 girls claim adverse reactions to the HPV vaccine – Irish Independent
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Irish Independent Another 18 girls claim adverse reactions to the HPV vaccine Irish Independent Jesper Mehlsen, director of research at Frederiksberg Hospital in Denmark, told the Sunday Independent: «We have noted a pattern of symptoms in a relatively large group of patients and that these symptoms seem to have a temporal association to the … …
Study protocol of “CHAPS”: a randomized controlled trial protocol of Care Coordination for Health Promotion and Activities in Parkinson’s Disease to improve the quality of care for individuals with Parkinson’s disease
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Parkinson's disease, the second most common neurodegenerative disease, is diagnostically defined by motor impairments, but also includes often under-recognized impairments in cognition, mood, sleep, and the au... from Neurology via xlomafota13 on Inoreader http://ift.tt/1IaVLuS via IFTTT
Observational cohort study of the natural history of Niemann-Pick disease type C in the UK: a 5-year update from the UK clinical database
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Niemann-Pick disease type C (NP-C) is a rare neurovisceral lipid storage disorder characterised by progressive, disabling neurological symptoms and premature death in most patients. During the last decade, nat... from Neurology via xlomafota13 on Inoreader http://ift.tt/1IaVLeC via IFTTT
Exploratory screening for Fabry’s disease in young adults with cerebrovascular disorders in northern Sardinia
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
The etiologic determinants of stroke in young adults remain a diagnostic challenge in up to one-fourth of cases. Increasing evidences led to consider Fabry's disease (FD) as a possible cause to check up. We ai... from Neurology via xlomafota13 on Inoreader http://ift.tt/1IaVLeA via IFTTT
Transient spurious intrathecal immunoglobulin synthesis in neurological patients after therapeutic apheresis
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
The analysis of cerebrospinal fluid (CSF) is usually done under steady-state conditions, when proteins (e.g., immunoglobulins) reach diffusion equilibrium between blood and CSF. However, little data has been p... from Neurology via xlomafota13 on Inoreader http://ift.tt/1JdO1Dr via IFTTT
International trends in health science librarianship part 17: a comparison of health science libraries with academic and research libraries
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Over the last 4 years this Regular Feature has looked at trends in health science librarianship in the 21st century. Although there are still a few more regions to be covered in this series, this issue explores general trends in academic and research libraries with a view to discovering whether the trends identified for […]
Preparing students for research: faculty/librarian collaboration in a pre-doctoral physical therapy research course
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract In this article, guest writers Susan Bigelow and Dr Salome Brooks from Springfield College, Massachusetts, present an overview of their evaluative research study in which a faculty professor and the liaison librarian collaborated to develop an information literacy course entitled Physical Therapy (PT) and Health care Research Skills, in order to teach necessary information […]
To the Editor.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
To the Editor. Isr Med Assoc J. 2015 Oct;17(10):660 Authors: Zeller L, Abu-Shakra M PMID: 26665330 [PubMed – indexed for MEDLINE] from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1ZdDCAR via IFTTT
HELMINTHS AND AUTOIMMUNITY: THE PECULIAR CASE OF TAENIA SOLIUM.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
HELMINTHS AND AUTOIMMUNITY: THE PECULIAR CASE OF TAENIA SOLIUM. Isr Med Assoc J. 2015 Oct;17(10):660 Authors: Galán-Puchades MT PMID: 26665329 [PubMed – indexed for MEDLINE] from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Pagqk2 via IFTTT
Progressive Brain Atrophy due to Chronic Alcohol Abuse.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Progressive Brain Atrophy due to Chronic Alcohol Abuse. Isr Med Assoc J. 2015 Oct;17(10):659 Authors: Slobodin G, Odeh M PMID: 26665328 [PubMed – in process] from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1ZdDAsA via IFTTT
Diagnosing Hyperperfusion Syndrome: CT Perfusion or Transcranial Doppler?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Diagnosing Hyperperfusion Syndrome: CT Perfusion or Transcranial Doppler? Isr Med Assoc J. 2015 Oct;17(10):656-8 Authors: Orion D, Yavne Y, Peretz S, Givaty G PMID: 26665327 [PubMed – in process] from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Pagq3F via IFTTT
Bone Marrow-Related Syncope.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Bone Marrow-Related Syncope. Isr Med Assoc J. 2015 Oct;17(10):653-5 Authors: Shmilovich H, Trestman S, Bak S, Aviram G, Banai S, Steinvil A, Keren G PMID: 26665326 [PubMed – in process] from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Pagoc4 via IFTTT
Socioeconomic Factors Affect Outcomes in Well-Differentiated Thyroid Cancer.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Socioeconomic Factors Affect Outcomes in Well-Differentiated Thyroid Cancer. Otolaryngol Head Neck Surg. 2015 Dec 15; Authors: Swegal WC, Singer M, Peterson E, Feigelson HS, Kono SA, Snyder S, Melvin TN, Calzada G, Ghai NR, Saman DM, Chang SS Abstract OBJECTIVES: The effects of socioeconomic status (SES) on the incidence of well-differentiated thyroid cancer (WDTC) are […]
Neck Incision Planning for Total Laryngectomy with Pharyngectomy.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Neck Incision Planning for Total Laryngectomy with Pharyngectomy. Otolaryngol Head Neck Surg. 2015 Dec 15; Authors: Clark JH, Feng AL, Morton K, Agrawal N, Richmon JD Abstract OBJECTIVES: To investigate the effect of skin incision location for total laryngectomy with pharyngectomy (TLP) on postoperative outcomes including wound dehiscence and infection rate. STUDY DESIGN: Case series […]
Adaptation of the Arabic Version of the Tinnitus Handicap Inventory.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Adaptation of the Arabic Version of the Tinnitus Handicap Inventory. Otolaryngol Head Neck Surg. 2015 Dec 15; Authors: Barake R, Rizk SA, Ziade G, Zaytoun G, Bassim M Abstract OBJECTIVE: To translate the Tinnitus Handicap Inventory (THI) into literary Arabic to come up with a unified Arabic version and to determine its validity and reliability […]
Cochlear Implantation in the Setting of Perioperative Anticoagulation and Antiplatelet Therapy.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Cochlear Implantation in the Setting of Perioperative Anticoagulation and Antiplatelet Therapy. Otolaryngol Head Neck Surg. 2015 Dec 15; Authors: Hunter JB, Carlson ML, Sweeney AD, Tombers NM, Wanna GB, Driscoll CL, Haynes DS Abstract OBJECTIVE: To describe surgical outcomes and perioperative complications in patients taking antiplatelet and anticoagulation medications while undergoing cochlear implantation. STUDY DESIGN: […]
AHI Outcomes Are Superior after Upper Airway Reconstructive Surgery in Adult CPAP Failure Patients.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
AHI Outcomes Are Superior after Upper Airway Reconstructive Surgery in Adult CPAP Failure Patients. Otolaryngol Head Neck Surg. 2015 Dec 15; Authors: Stewart S, Huang J, Mohorikar A, Jones A, Holmes S, MacKay SG Abstract OBJECTIVE: This study aims to evaluate Apnea-Hypopnea Index (AHI) outcomes of upper airway adult obstructive sleep apnea (OSA) reconstructive surgery, […]
Olfactory Neuroblastoma: Fate of the Neck-A Long-term Multicenter Retrospective Study.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Olfactory Neuroblastoma: Fate of the Neck-A Long-term Multicenter Retrospective Study. Otolaryngol Head Neck Surg. 2015 Dec 15; Authors: Nalavenkata SB, Sacks R, Adappa ND, Palmer JN, Purkey MT, Feldman MD, Schlosser RJ, Snyderman CH, Wang EW, Woodworth BA, Smee R, Havas TE, Gallagher R, Harvey RJ Abstract OBJECTIVE: Olfactory neuroblastoma and the management of neck […]
Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes. Mol Neurobiol. 2015 Dec 15; Authors: da Silva Dias IC, Carabelli B, Ishii DK, de Morais H, de Carvalho MC, Rizzo de Souza LE, Zanata SM, Brandão ML, Cunha TM, Ferraz AC, Cunha JM, Zanoveli JM Abstract Diabetes is a chronic disease […]
Should uterus transplants be publicly funded?
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Should uterus transplants be publicly funded? J Med Ethics. 2015 Dec 15; Authors: Wilkinson S, Williams NJ Abstract Since 2000, 11 human uterine transplantation procedures (UTx) have been performed across Europe and Asia. Five of these have, to date, resulted in pregnancy and four live births have now been recorded. The most significant obstacles to […]
Medical Humanities – the Historical Significance and Mission in Medical Education.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Medical Humanities – the Historical Significance and Mission in Medical Education. J UOEH. 2015;37(4):273-291 Authors: Fujino A Abstract In this paper we consider the significance and mission of medical humanities in medical education from the following six viewpoints: (1) misunderstanding of the medical humanities; (2) its historical development; (3) the criteria for the ideal physician; […]
GP is struck off for dishonesty for second time.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Related Articles GP is struck off for dishonesty for second time. BMJ. 2015;351:h5498 Authors: Dyer C PMID: 26472757 [PubMed – indexed for MEDLINE] from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1YmPjD1 via IFTTT
“Intercellular bridges” in a case of well differentiated squamous carcinoma
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Intercellular bridges may aide in definitive identification of malignant cell origin, especially in squamous cell carcinoma. They are difficult to identify in routine cytologic specimens and are especially rare in smear preparations. Herein, we present images of intercellular bridges from a case of well differentiated squamous cell carcinoma of the esophagus in a cytologic specimen obtained from FNA of a paraesophageal lymph node. Diagn. Cytopathol. 2015. © 2015 Wiley Periodicals, Inc. from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1OabY6a via IFTTT
Can galectin-3 be a useful marker for conventional papillary thyroid microcarcinoma?
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
Background Galectin-3 staining of fine-needle aspiration (FNA) samples is very useful for diagnosis of thyroid malignancy. As reported in several studies, galectin-3 is associated with prognostic factor in papillary thyroid carcinoma, but its expression and prognostic role has not been evaluated in papillary microcarcinoma (PTMC). This study was performed to investigate the prevalence of galectin-3 in preoperative ultrasonography (US)-guided FNA cytology and to evaluate the association between galectin-3 expression and prognostic factors of PTMC. Methods Between January 2011 and...περισσότερα »
The Morrison technique: a free-hand method for capturing photomicrographs using a smartphone
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1TRH5RW via IFTTT
Frequency of Cutis Laxa–Like Clinical Features and Elastolysis in Scleromyxedema: A Retrospective Clinicopathologic Study of 19 Patients With Scleromyxedema
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Background Cutis laxa–like features were observed in a subset of patients with scleromyxedema. Given this observation, clinical and histopathologic features of scleromyxedema were reviewed in correlation with elastic tissue staining. Methods We retrospectively reviewed clinical records and histopathologic features from patients with scleromyxedema seen at our institution from 1992 through 2013. We also evaluated available skin biopsies with an elastin stain and assessed whether dermal elastin fibers were diminished in density or were fragmented (or both). Results Nine...περισσότερα »
Identification of a novel hydroxylated metabolite of 2,2′,3,5′,6-pentachlorobiphenyl formed in whole poplar plants
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Polychlorinated biphenyls (PCBs) are a group of persistent organic pollutants consisting of 209 congeners. Oxidation of several PCB congeners to hydroxylated PCBs (OH-PCBs) in whole poplar plants has been reported before. Moreover, 2,2′,3,5′,6-pentachlorobiphenyl (PCB95), as a chiral congener, has been previously shown to be atropselectively taken up and transformed in whole poplar plants. The […]
Cytogenetic effects of three commercially formulated pesticides on somatic and germ cells of Allium cepa
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Cytological effects of Endosri-ES (endosulfan), Nuvan-NU (dichlorvos), and Kvistin-KS (carbendazim) were evaluated on mitotic and meiotic cells of Allium cepa. Test concentrations were chosen by calculating EC50 values of formulated ES, NU, and KS, which turned to be 60, 200, and 500 ppm (parts per million), respectively. Cytological studies were undertaken on root meristem […]
Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Fully brominated diphenyl ether (BDE-209) is a flame retardant widely used in plastics and textiles. Because of its high persistence, humans are exposed to it continuously, mainly via dust ingestion. We investigated effects of BDE-209 on renal function and oxidative stress development in the kidney after subacute exposure in rats. Five groups of animals […]
To stop cancer’s spread, take out its communication channels https://t.co/YzOpkwuHNI
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
To stop cancer’s spread, take out its communication channels https://t.co/YzOpkwuHNI from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/677438877947195392 via IFTTT
Array-based molecular karyotyping in fetal brain malformations: Identification of novel candidate genes and chromosomal regions
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
BACKGROUND For the majority of congenital brain malformations, the underlying cause remains unknown. Recent studies have implicated rare copy number variations (CNVs) in their etiology. METHODS Here, we used array-based molecular karyotyping to search for causative CNVs in 33 fetuses of terminated pregnancies with prenatally detected brain malformations and additional extracerebral anomalies. RESULTS In 11 […]
Epidemiologic characteristics and time trend in the prevalence of anotia and microtia in China
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background Previous studies have shown an inconsistent time trend on the prevalence of anotia and microtia. Little has been reported on the epidemiologic characteristics of anotia and microtia in the Chinese population. Methods Data from 1996–2007 were obtained from the Chinese Birth Defects Monitoring Network in China. Birth prevalence of anotia and microtia were assessed […]
Assessment of the Protein–Protein Interactions in a Highly Concentrated Antibody Solution by Using Raman Spectr oscopy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
ABSTRACT Purpose To investigate the protein–protein interactions of a highly concentrated antibody solution that could cause oligomerization or aggregation and to develop a better understanding of the optimization of drug formulations. Methods In this study, we used Raman spectroscopy to investigate the structure and interactions of a highly concentrated antibody solution over a wide range […]
Laparoscopic alternatives to fundoplication for gastroesophageal reflux: the role of magnetic augmentation and electrical stimulation of the lower esophageal sphincter
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Reflux symptoms are very common, and despite modern medication they are a major cause of disease burden and loss of quality of life worldwide. Laparoscopic anti-reflux surgery is the only current effective alternative but suffers from the risks of long-term side effects. Surgery also suffers variation in standards and outcomes. Magnetic augmentation and electrical […]
Fatal Myocarditis Associated With HHV-6 Following Immunosuppression in Two Children
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Fatal myocarditis is a rare complication in immunosuppressed children. Recent reports have linked human herpesvirus 6 (HHV-6) infection, typically a benign infection in childhood, with myocarditis. HHV-6 can reactivate during periods of immunosuppression. Here, we report 2 cases in which children were immunosuppressed, one for treatment of Evans syndrome and the other post hematopoietic stem […]
Use of a Checklist and Clinical Decision Support Tool Reduces Laboratory Use and Improves Cost
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
OBJECTIVE: We hypothesized that a daily rounding checklist and a computerized order entry (CPOE) rule that limited the scheduling of complete blood cell counts and chemistry and coagulation panels to a 24-hour interval would reduce laboratory utilization and associated costs. METHODS: We performed a retrospective analysis of these initiatives in a pediatric cardiovascular ICU (CVICU) […]
Programmierung von kindlichem Übergewicht durch perinatale Überflusssituation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Zusammenfassung Kindliches Übergewicht und Adipositas sind dringliche Gesundheitsprobleme mit weitreichenden Folgen bis ins Erwachsenenalter. Durch noch wenig verstandene Mechanismen, die als „fetale Programmierung“ bezeichnet werden, werden in den frühesten Lebensphasen bereits Krankheitsrisiken geprägt, die die kindliche Übergewichtsproblematik zu verstärken scheinen. Eine perikonzeptionelle maternale Adipositas, aber auch weitere perinatale Risikofaktoren, wie disproportional hohe Gewichtszunahme in der […]
Gerichtsgutachten in der Pädiatrie
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Zusammenfassung Sachverständigengutachten für Gerichte sind auch in der Kinder- und Jugendmedizin eine wichtige Aufgabe, die häufig nur in Kooperation mit anderen Fachdisziplinen erfolgen kann. Der Pädiater soll dabei u. a. Kausalzusammenhänge überprüfen, mögliche Differenzialdiagnosen berücksichtigen und das Ausmaß einer Schädigung bewerten. Aus der Erfahrung von über 100 Gerichtsgutachten werden mehrere anonymisierte Beispiele vorgestellt, der formale Aufbau […]
Standardized data collection to build prediction models in oncology: a prototype for rectal cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1O8m0yj via IFTTT
Healthcare provider contact for children with symptoms of sleep-disordered breathing: a population survey
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Research Articles G Gudnadottir, A Ehnhage, M Bende, M Andersson, A Cervin, L O Cardell, J Hellgren The Journal of Laryngology Otology, FirstView Article(s), 6 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1P8Jdnb via IFTTT
Giant basal cell carcinoma of the face: surgical management and challenges for reconstruction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Research Articles A Maimaiti, A Mijiti, A Yarbag, A Moming The Journal of Laryngology Otology, FirstView Article(s), 7 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QurKJk via IFTTT
Simultaneous cochlear implantation and labyrinthectomy for advanced Ménière’s disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Rapid Communication R L Heywood, M D Atlas The Journal of Laryngology Otology, FirstView Article(s), 3 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1P8Jd6R via IFTTT
Alterations of mucosa of the larynx and hypopharynx in patients with mucopolysaccharidoses
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Research Articles A Keilmann, F Bendel, S Nospes, C Lampe, A K Läßig The Journal of Laryngology Otology, FirstView Article(s), 7 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1P8Jfvi via IFTTT
A tale of two epidemics: gender differences in socio-demographic characteristics and sexual behaviors among HIV positive individuals in Mexico City
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Background To date, the HIV epidemic in Mexico has been concentrated mainly among men who have sex with men, butheterosexual transmission, particularly to women, is increasingly important. This study examine gender differences in socio-demographic characteristics and risk behaviors of HIV positive individuals in Mexico City. Methods We analyzed data from a cross-sectional survey of […]
Oligonucleotide-stabilized fluorescent silver nanoclusters for specific and sensitive detection of biotin
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες
[image: CrossMark.jpg] *Analyst*, 2015, Accepted Manuscript *DOI*: 10.1039/C5AN02307F, Paper Xiaoli Xiong, Yan Tang, Jingjin Zhao, Shulin Zhao A novel biotin fluorescent probe based on oligonucleotide-stabilized silver nanoclusters (DNA-AgNCs) was synthesized by employing biotinylated cytosine-rich sequence as synthesized template. The fluorescence property of the DNA-AgNCs is related to... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1ZdDCRm via IFTTT
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