5th International ACC Symposium: Classification of Adrenocortical Cancers from Pathology to Integrated Genomics: Real Advances or Lost in Translation ?
Abstract For the clinician, despite its rarity, adrenocortical cancer is a heterogeneous tumor both in term of steroid excess and tumor evolution. For patient management, it is crucial to have an accurate vision of this heterogeneity, in order to use a correct tumor classification. Pathology is the best way to classify operated adrenocortical tumors: to recognize their adrenocortical nature and to differentiate benign from malignant tumors. Among malignant tumors pathology also aims at prognosis assessment. Although progress has being made for prognosis assessment, there is still a... περισσότερα »
Evaluation of Interforaminal Mandible Region of Individuals With Pierre Robin Sequence and Treacher Collins Syndrome Through the Cone-Beam Computed Tomography.
Evaluation of Interforaminal Mandible Region of Individuals With Pierre Robin Sequence and Treacher Collins Syndrome Through the Cone-Beam Computed Tomography.: The Pierre Robin sequence (PRS) and the Treacher Collins syndrome (TCS) are conditions that cause significant abnormalities of jaw. This study was conducted in anticipation of evaluating the morphology of interforaminal region and identify the anatomic variations: anterior loop and mandibular incisive canal, in individuals with PRS and TCS by cone-beam computed tomography and compare them with individuals without craniofacial... περισσότερα »
The Communication Patterns Between the Buccal Trunks of the Facial Nerve and the Infraorbital Nerve in the Midface.
A Cadaveric Study of the Communication Patterns Between the Buccal Trunks of the Facial Nerve and the Infraorbital Nerve in the Midface.: Most nerve communications reported in the literature were found between the terminal branches. This study aimed to clarify and classify patterns of proximal communications between the buccal branches (BN) of the facial nerve and the infraorbital nerve (ION). The superficial musculoaponeurotic system protects any communication sites from conventional dissections. Based on this limitation, the soft tissues of each face were peeled off the facial skul... περισσότερα »
Patient-Specific Orbital Implants: Development and Implementation of Technology for More Accurate Orbital Reconstruction.
Patient-Specific Orbital Implants: Development and Implementation of Technology for More Accurate Orbital Reconstruction.: Fracture of the orbital floor is commonly seen in facial trauma. Accurate anatomical reconstruction of the orbital floor contour is challenging. The authors demonstrate a novel method to more precisely reconstruct the orbital floor on a 50-year-old female who sustained an orbital floor fracture following a fall. Results of the reconstruction show excellent reapproximation of the native orbital floor contour and complete resolution of her enopthalmos and facial a... περισσότερα »
Analysis of Lid Contour in Thyroid Eye Disease With Upper and Lower Eyelid Retraction Using Multiple Radial Midpupil Lid Distances.
Analysis of Lid Contour in Thyroid Eye Disease With Upper and Lower Eyelid Retraction Using Multiple Radial Midpupil Lid Distances.: Purpose: The aim of this study was to analyze upper and lower eyelid contours in adult patients with thyroid eye disease (TED) and normal adults using a software program that measures multiple radial midpupil lid distance (MPLD). Methods: Analysis targeted 61 eyes from 61 normal adults who had never undergone eyelid surgery or ophthalmic surgery and 63 eyes from 63 patients with TED. Digital pictures of primary gaze were analyzed using custom software. ...περισσότερα »
Is age a limiting factor for adaptation to cochlear implant?
Is age a limiting factor for adaptation to cochlear implant?: AbstractThe influence of age on adaptation to cochlear implant (CI) is still being contested in the literature. The aim of this study was twofold. First, hearing outcomes in quiet conditions were compared between CI users implanted over and under the age of 70 years. Second, the effect of the duration of auditory deprivation was investigated. The study design is a retrospective review and the setting is in academic tertiary referral center. One hundred and twenty-one postlingually deafened implanted adults participated i... περισσότερα »
Intratemporal facial nerve schwannoma
Intratemporal facial nerve schwannoma: clinical presentation and management: AbstractFacial nerve schwannoma is the most common facial nerve tumor, but its therapeutic strategy remains debated. The aim of this study is to analyze the facial nerve function and the hearing outcomes after surgery or wait-and-scan policy in a facial nerve schwannoma series. A monocentric retrospective review of medical charts of patients followed for an intratemporal facial nerve schwannoma between 1988 and 2013 was performed. Twenty-two patients were included. Data were extracted pertaining to the fo...περισσότερα »
Increased Frontal Response May Underlie Decreased Tinnitus Severity
Increased Frontal Response May Underlie Decreased Tinnitus Severity: by Jake R. Carpenter-Thompson, Sara Schmidt, Edward McAuley, Fatima T. Husain Objectives The overall goal of the study was to identify functional and behavioral differences between individuals with higher tinnitus distress and individuals with lower tinnitus distress. Subsequent exploratory analyses were conducted to investigate the role physical activity may have on the observed results between high and low distress groups. The purpose of the experiment was to identify brain regions to be targeted in future in...περισσότερα »
Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America
It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1YjBPgF via IFTTT
Bethesda Categorization of Thyroid Nodule Cytology and Prediction of Thyroid Cancer Type and Prognosis
Bethesda Categorization of Thyroid Nodule Cytology and Prediction of Thyroid Cancer Type and Prognosis: Thyroid , Vol. 0, No. 0. Author information Xiaoyun Liu,1,2 Marco Medici,5 Norra Kwong,1 Trevor E. Angell,1 Ellen Marqusee,1 Matthew I. Kim,1 P. Reed Larsen,1 Nancy L. Cho,4 Matthew A. Nehs, 4 Daniel T. Ruan,4 Atul Gawande,4 Francis Moore Jr,4Justine Barletta,3 Jeffrey F. Krane,3 Edmund S. Cibas,3 Tao Yang,2 and Erik K. Alexander1 1Thyroid Unit, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. 2Department of Endocrinology, Fir...περισσότερα »
Full-Thickness Skin Burn Caused by Radiofrequency Ablation of a Benign Thyroid Nodule
Full-Thickness Skin Burn Caused by Radiofrequency Ablation of a Benign Thyroid Nodule: Thyroid , Vol. 0, No. 0. Author information Stella Bernardi,1 Valentina Lanzilotti,1 Giovanni Papa,2 Nicola Panizzo,2 Chiara Dobrinja,3 Bruno Fabris,1 and Fulvio Stacul4 1Department of Medical, Surgical, and Health Sciences, University of Trieste, Cattinara Teaching Hospital, Trieste,Italy. 2Department of Plastic and Reconstructive Surgery, University of Trieste, Cattinara Teaching Hospital, Trieste,Italy. 3Department of General Surgery, University of Trieste, Cattinara Teaching Hospital, Trieste... περισσότερα »
Induction Chemotherapy Followed by Cetuximab Plus Definitive Radiotherapy Versus Radiation Plus Cisplatin
Induction Chemotherapy Followed by Cetuximab Plus Definitive Radiotherapy Versus Radiation Plus Cisplatin: *Condition*: Squamous Cell Carcinoma of the Head and Neck *Interventions*: Drug: docetaxel - cisplatin - 5-fluorouracil; Radiation: radiotherapy; Drug: cetuximab; Drug: cisplatin; Radiation: radiotherapy *Sponsor*: Gruppo Oncologico del Nord-Ovest ArmsAssigned InterventionsExperimental: ARM A Induction chemotherapy: TCF (Vermorken, N Eng J Med 2007) Definitive treatment: RT + C-mab (Bonner, N Eng J Med 2006) Drug: docetaxel - cisplatin - 5-fluorouracil docetaxel... περισσότερα »
Increased Frontal Response May Underlie Decreased Tinnitus Severity
Increased Frontal Response May Underlie Decreased Tinnitus Severity: by Jake R. Carpenter-Thompson, Sara Schmidt, Edward McAuley, Fatima T. Husain Objectives The overall goal of the study was to identify functional and behavioral differences between individuals with higher tinnitus distress and individuals with lower tinnitus distress. Subsequent exploratory analyses were conducted to investigate the role physical activity may have on the observed results between high and low distress groups. The purpose of the experiment was to identify brain regions to be targeted in future in...περισσότερα »
Statistical Learning, Syllable Processing, and Speech Production in Healthy Hearing and Hearing-Impaired Preschool Children: A Mismatch Negativity Study
Statistical Learning, Syllable Processing, and Speech Production in Healthy Hearing and Hearing-Impaired Preschool Children: A Mismatch Negativity Study: [image: image]Objectives: The objectives of the present study were to investigate temporal/spectral sound-feature processing in preschool children (4 to 7 years old) with peripheral hearing loss compared with age-matched controls. The results verified the presence of statistical learning, which was diminished in children with hearing impairments (HIs), and elucidated possible perceptual mediators of speech production. Design: Percep...περισσότερα »
Everyday Listening Performance of Children Before and After Receiving a Second Cochlear Implant: Results Using the Parent Version of the Speech, Spatial, and Qualities of Hearing Scale
Everyday Listening Performance of Children Before and After Receiving a Second Cochlear Implant: Results Using the Parent Version of the Speech, Spatial, and Qualities of Hearing Scale: [image: image]Objectives: To evaluate change in individual children’s performance in general areas of everyday listening following sequential bilateral implantation, and to identify the specific types of listening scenarios in which performance change occurred. The first hypothesis was that parent performance ratings for their child would be higher in the bilateral versus unilateral implant condition... περισσότερα »
The Effect of Residual Acoustic Hearing and Adaptation to Uncertainty on Speech Perception in Cochlear Implant Users: Evidence From Eye-Tracking
The Effect of Residual Acoustic Hearing and Adaptation to Uncertainty on Speech Perception in Cochlear Implant Users: Evidence From Eye-Tracking: [image: image]Objectives: While outcomes with cochlear implants (CIs) are generally good, performance can be fragile. The authors examined two factors that are crucial for good CI performance. First, while there is a clear benefit for adding residual acoustic hearing to CI stimulation (typically in low frequencies), it is unclear whether this contributes directly to phonetic categorization. Thus, the authors examined perception of voicing (... περισσότερα »
Hearing in Noise Test for Children
The Norwegian Hearing in Noise Test for Children: [image: image]Objectives: The aims of this study were to create 12 ten-sentence lists for the Norwegian Hearing in Noise Test for children, and to use these lists to collect speech reception thresholds (SRTs) in quiet and in noise to assess speech perception in normal hearing children 5 to 13 years of age, to establish developmental trends, and to compare the results with those of adults. Data were collected in an anechoic chamber and in an audiometric test room, and the effect of slight room reverberation was estimated. Design: The N...περισσότερα »
Shifting Fundamental Frequency in Simulated Electric-Acoustic Listening: Effects of F0 Variation
Shifting Fundamental Frequency in Simulated Electric-Acoustic Listening: Effects of F0 Variation: [image: image]Objective: Shifting the mean fundamental frequency (F0) of target speech down in frequency may be a way to provide the benefits of electric-acoustic stimulation (EAS) to cochlear implant (CI) users whose limited residual hearing precludes a benefit typically, even with amplification. However, previous study showed a decline in the amount of benefit at the greatest downward frequency shifts, and the authors hypothesized that this might be related to F0 variation. Thus, in t... περισσότερα »
Predicting Speech-in-Noise Recognition From Performance on the Trail Making Test: Results From a Large-Scale Internet Study
Predicting Speech-in-Noise Recognition From Performance on the Trail Making Test: Results From a Large-Scale Internet Study: [image: image] Objective: The aim of the study was to investigate the utility of an internet-based version of the trail making test (TMT) to predict performance on a speech-in-noise perception task. Design: Data were taken from a sample of 1509 listeners between ages 18 and 91 years old. Participants completed computerized versions of the TMT and an adaptive speech-in-noise recognition test. All testing was conducted via the internet. Results: The results indi... περισσότερα »
Subjective Ratings of Fatigue and Vigor in Adults With Hearing Loss Are Driven by Perceived Hearing Difficulties Not Degree of Hearing Loss
Subjective Ratings of Fatigue and Vigor in Adults With Hearing Loss Are Driven by Perceived Hearing Difficulties Not Degree of Hearing Loss: [image: image]Objectives: Anecdotal reports and qualitative research suggests that fatigue is a common, but often overlooked, accompaniment of hearing loss which negatively affects quality of life. However, systematic research examining the relationship between hearing loss and fatigue is limited. In this study, the authors examined relationships between hearing loss and various domains of fatigue and vigor using standardized and validated meas... περισσότερα »
Finite Verb Morphology in the Spontaneous Speech of Dutch-Speaking Children With Hearing Loss
Finite Verb Morphology in the Spontaneous Speech of Dutch-Speaking Children With Hearing Loss: [image: image]Objective: In this study, the acquisition of Dutch finite verb morphology is investigated in children with cochlear implants (CIs) with profound hearing loss and in children with hearing aids (HAs) with moderate to severe hearing loss. Comparing these two groups of children increases our insight into how hearing experience and audibility affect the acquisition of morphosyntax. Design: Spontaneous speech samples were analyzed of 48 children with CIs and 29 children with HAs, ag... περισσότερα »
Nonmuscle Myosin Heavy Chain IIA Mutation Predicts Severity and Progression of Sensorineural Hearing Loss in Patients With MYH9-Related Disease
Nonmuscle Myosin Heavy Chain IIA Mutation Predicts Severity and Progression of Sensorineural Hearing Loss in Patients With MYH9-Related Disease: [image: image]Objectives: MYH9-related disease (MYH9-RD) is an autosomal- dominant disorder deriving from mutations in MYH9, the gene for the nonmuscle myosin heavy chain (NMMHC)-IIA. MYH9-RD has a complex phenotype including congenital features, such as thrombocytopenia, and noncongenital manifestations, namely sensorineural hearing loss (SNHL), nephropathy, cataract, and liver abnormalities. The disease is caused by a limited number of mu... περισσότερα »
Development of Open-Set Word Recognition in Children: Speech-Shaped Noise and Two-Talker Speech Maskers
Development of Open-Set Word Recognition in Children: Speech-Shaped Noise and Two-Talker Speech Maskers: [image: image]Objective: The goal of this study was to establish the developmental trajectories for children’s open-set recognition of monosyllabic words in each of two maskers: two-talker speech and speech-shaped noise. Design: Listeners were 56 children (5 to 16 years) and 16 adults, all with normal hearing. Thresholds for 50% correct recognition of monosyllabic words were measured in a two-talker speech or a speech-shaped noise masker in the sound field using an open-set task. ...περισσότερα »
The Effects of Noise and Reverberation on Listening Effort in Adults With Normal Hearing
The Effects of Noise and Reverberation on Listening Effort in Adults With Normal Hearing: [image: image]Objectives: The purpose of this study was to investigate the effects of background noise and reverberation on listening effort. Four specific research questions were addressed related to listening effort: (A) With comparable word recognition performance across levels of reverberation, what are the effects of noise and reverberation on listening effort? (B) What is the effect of background noise when reverberation time is constant? (C) What is the effect of increasing reverberation... περισσότερα »
Masking Period Patterns and Forward Masking for Speech-Shaped Noise: Age-Related Effects
Masking Period Patterns and Forward Masking for Speech-Shaped Noise: Age-Related Effects: [image: image]Objective: The purpose of this study was to assess age-related changes in temporal resolution in listeners with relatively normal audiograms. The hypothesis was that increased susceptibility to nonsimultaneous masking contributes to the hearing difficulties experienced by older listeners in complex fluctuating backgrounds. Design: Participants included younger (n = 11), middle-age (n = 12), and older (n = 11) listeners with relatively normal audiograms. The first phase of the stud...περισσότερα »
The Effect of Functional Hearing and Hearing Aid Usage on Verbal Reasoning in a Large Community-Dwelling Population
The Effect of Functional Hearing and Hearing Aid Usage on Verbal Reasoning in a Large Community-Dwelling Population: [image: image] Objectives: Verbal reasoning performance is an indicator of the ability to think constructively in everyday life and relies on both crystallized and fluid intelligence. This study aimed to determine the effect of functional hearing on verbal reasoning when controlling for age, gender, and education. In addition, the study investigated whether hearing aid usage mitigated the effect and examined different routes from hearing to verbal reasoning. Design: ... περισσότερα »
Auditory Training Effects on the Listening Skills of Children With Auditory Processing Disorder
Auditory Training Effects on the Listening Skills of Children With Auditory Processing Disorder: [image: image]Objectives: Children with auditory processing disorder (APD) typically present with “listening difficulties,”’ including problems understanding speech in noisy environments. The authors examined, in a group of such children, whether a 12-week computer-based auditory training program with speech material improved the perception of speech-in-noise test performance, and functional listening skills as assessed by parental and teacher listening and communication questionnaires. ... περισσότερα »
Evaluation of a Modified User Guide for Hearing Aid Management
Evaluation of a Modified User Guide for Hearing Aid Management: [image: image] Objectives: This study investigated if a hearing aid user guide modified using best practice principles for health literacy resulted in superior ability to perform hearing aid management tasks, compared with the user guide in the original form. Design: This research utilized a two-arm study design to compare the original manufacturer’s user guide with a modified user guide for the same hearing aid—an Oticon Acto behind-the-ear aid with an open dome. The modified user guide had a lower reading grade level ... περισσότερα »
The Importance of Acoustic Temporal Fine Structure Cues in Different Spectral Regions for Mandarin Sentence Recognition
The Importance of Acoustic Temporal Fine Structure Cues in Different Spectral Regions for Mandarin Sentence Recognition: [image: image]Objectives: To study the relative contribution of acoustic temporal fine structure (TFS) cues in low-, mid-, and high-frequency regions to Mandarin sentence recognition. Design: Twenty-one subjects with normal hearing were involved in a study of Mandarin sentence recognition using acoustic TFS. The acoustic TFS information was extracted from 10 3-equivalent rectangular bandwidth-wide bands within the range 80 to 8858 Hz using the Hilbert transform and... περισσότερα »
Word Recognition Variability With Cochlear Implants: “Perceptual Attention” Versus “Auditory Sensitivity”
Word Recognition Variability With Cochlear Implants: “Perceptual Attention” Versus “Auditory Sensitivity”: [image: image]Objectives: Cochlear implantation does not automatically result in robust spoken language understanding for postlingually deafened adults. Enormous outcome variability exists, related to the complexity of understanding spoken language through cochlear implants (CIs), which deliver degraded speech representations. This investigation examined variability in word recognition as explained by “perceptual attention” and “auditory sensitivity” to acoustic cues underlying...περισσότερα »
Audiometric Characteristics of a Dutch DFNA10 Family With Mid-Frequency Hearing Impairment
Audiometric Characteristics of a Dutch DFNA10 Family With Mid-Frequency Hearing Impairment: [image: image]Objectives: Mutations in EYA4 can cause nonsyndromic autosomal dominant sensorineural hearing impairment (DFNA10) or a syndromic variant with hearing impairment and dilated cardiomyopathy. A mutation in EYA4 was found in a Dutch family, causing DFNA10. This study is focused on characterizing the hearing impairment in this family. Design: Whole exome sequencing was performed in the proband. In addition, peripheral blood samples were collected from 23 family members, and segregatio... περισσότερα »
Clinical Validity of hearScreen™ Smartphone Hearing Screening for School Children
Clinical Validity of hearScreen™ Smartphone Hearing Screening for School Children: [image: image]Objectives: The study aimed to determine the validity of a smartphone hearing screening technology (hearScreen™) compared with conventional screening audiometry in terms of (1) sensitivity and specificity, (2) referral rate, and (3) test time. Design: One thousand and seventy school-age children in grades 1 to 3 (8 ± 1.1 average years) were recruited from five public schools. Children were screened twice, once using conventional audiometry and once with the smartphone hearing screening. S... περισσότερα »
MAGnesium-oral supplementation to reduce PAin in patients with severe PERipheral arterial occlusive disease: the MAG-PAPER randomised clinical trial protocol
Introduction Magnesium exerts analgaesic effects in several animal pain models, as well as in patients affected by acute postoperative pain and neuropathic chronic pain. There is no evidence that magnesium can modulate pain in patients with peripheral arterial occlusive disease (PAOD). We describe the protocol of a single-centre randomised double-blind clinical trial aimed at assessing the efficacy of oral magnesium supplementation in controlling severe pain in patients with advanced PAOD. Methods and analysis Adult patients affected by PAOD at stages III and IV of Lèriche-Fontai... περισσότερα »
Exercise Programme in Endometrial Cancer; Protocol of the Feasibility and Acceptability Survivorship Trial (EPEC-FAST)
Introduction Obesity has been associated with impaired quality of life and poorer outcomes in endometrial cancer survivors. Lifestyle interventions promoting exercise and weight reduction have been proposed for survivorship care. However, studies evaluating exercise programmes for endometrial cancer survivors are lacking. Purpose The objective of this study is to evaluate the feasibility of an individualised exercise intervention for endometrial cancer survivors to improve quality of life. Methods and analysis This is a feasibility study in which women will undergo a 10-week ex... περισσότερα »
VITALITY trial: protocol for a randomised controlled trial to establish the role of postnatal vitamin D supplementation in infant immune health
Introduction Postnatal vitamin D supplementation may be associated with a reduction in IgE-mediated food allergy, lower respiratory tract infections and improved bone health. Countries in the Northern hemisphere recommend universal infant vitamin D supplementation to optimise early vitamin D levels, despite the absence of large trials proving safety or efficacy for any disease outcome. With the aim of determining the clinical and cost-effectiveness of daily vitamin D supplementation in breastfed infants from age 6–8 weeks to 12 months of age, we have started a double-blind, rando... περισσότερα »
Primary care consultation rates among people with and without severe mental illness: a UK cohort study using the Clinical Practice Research Datalink
Objectives Little is known about service utilisation by patients with severe mental illness (SMI) in UK primary care. We examined their consultation rate patterns and whether they were impacted by the introduction of the Quality and Outcomes Framework (QOF), in 2004. Design Retrospective cohort study using individual patient data collected from 2000 to 2012. Setting 627 general practices contributing to the Clinical Practice Research Datalink, a large UK primary care database. Participants SMI cases (346 551) matched to 5 individuals without SMI (1 732 755) on age, gender and... περισσότερα »
Bushehr Elderly Health (BEH) Programme, phase I (cardiovascular system)
Purpose The main objective of the Bushehr Elderly Health Programme, in its first phase, is to investigate the prevalence of cardiovascular risk factors and their association with major adverse cardiovascular events. Participants Between March 2013 and October 2014, a total of 3000 men and women aged ≥60 years, residing in Bushehr, Iran, participated in this prospective cohort study (participation rate=90.2%). Findings to date Baseline data on risk factors, including demographic and socioeconomic status, smoking and medical history, were collected through a modified WHO MONICA q... περισσότερα »
Trends in serum creatinine testing in Oxfordshire, UK, 1993-2013: a population-based cohort study
Objectives To determine how many kidney function tests are done, on whom, how frequently they are performed and how they have changed over time. Design Retrospective study of all serum creatinine, urine albumin and urine creatinine tests. Setting Primary and secondary care in Oxfordshire from 1993 to 2013. Participants Unselected population of 1 220 447 people. Main outcome measures The total number of creatinine and urinary protein tests ordered from primary and secondary care and the number of tests per year stratified by categories of estimated glomerular filtration rate (...περισσότερα »
A useful option to obtain maximal foreign body removal and better prognosis in high pressure injection injuries: Negative pressure wound therapy with instillation
None declared. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1T2JZTU via IFTTT
Currently known risk factors for hypertrophic skin scarring: A review
To provide an overview of risk factors for hypertrophic scarring. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1lRzusf via IFTTT
Treatment of hydrofluoric acid burns of the fingers
With great interest, we read the article published by Kim and colleagues, who reported their experience treating a 33-year-old man with thumb hydrofluoric acid burns using free flap reconstruction in the early stage.1 We appreciate the authors' superb microsurgery technique. However, we have some concerns regarding the treatment and management of this patient. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1T2JZn0 via IFTTT
Pedicled distal phalanx fillet flap for finger length preservation in trauma
Lawnmower injuries to the digits are becoming increasingly common and are often complex in nature with multiple levels of injury. The management of these injuries as with that of other hand injuries is often tailored to the individual patient considering factors such as occupation and hobbies with the ultimate goal of restoration of function and a sensate fingertip.The concept of using amputated, mangled or non-salvageable parts in a form of fillet flap has become more common in the recent years. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1lRztEx via IFTTT
Results of combined vascular reconstruction by means of AV-Loops and free flap transfer in patients with soft tissue defects
Free flap transplantation to vascular reconstructions as arteriovenous loops and has been established in centers as a feasible therapeutic option for defect reconstruction in absence of proper recipient vessels, caused by oncologic resections, radiation or trauma. We report our 10-years experience in free flap transplantation after vascular reconstruction with special emphasis on complication rate and postoperative mobility. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1T2JZ6l via IFTTT
A comparison of long-term cost and clinical outcomes between the two-stage sequence expansor/prosthesis and autologous deep inferior epigastric flap methods for breast reconstruction in a public hospital
Postmastectomy breast reconstruction involves the use of large amounts of hospital resources. This study provides comparative data on the clinical results and long-term economic costs of two methods of breast reconstruction in a public hospital. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1lRzsAC via IFTTT
Impact of the number of veins repaired in short-term digital replantation survival rate
Venous congestion/insufficiency plays a major role in failure of finger replantation. Despite acceptable salvage rates with postoperative anticoagulation or leeching, operative technique remains the most important predictor of success. However, there are no indications in the literature on the benefit of anastomosing single versus multiple veins. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1T2JVUj via IFTTT
“Pelvic-Perineal Reconstruction with the Combined Transverse Upper Gracilis and Profunda Artery Perforator (TUG-PAP) Flap”
None of the authors received any funds or has any financial interests to disclose. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1lRzp80 via IFTTT
Volpara as a measurement tool for breast volume
None of the authors has a financial interest in any of the products, devices, or drugs mentioned in this manuscript. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1T2JYiE via IFTTT
Assessment of sural flap microcirculation: Which position maintains the optimal perfusion?
Limb elevation is a common practice to reduce edema and to increase venous drainage. Considering the anatomy of the sural flap with retrograde perfusion and hence potentially difficult blood outflow, the best angle to positioning the leg following operation is not yet known. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1lRzqsw via IFTTT
A single nucleotide polymorphism in the Epstein-Barr virus genome is strongly associated with a high risk of nasopharyngeal carcinoma
Epstein-Barr virus (EBV) commonly infects the general population and has been associated with nasopharyngeal carcinoma (NPC), which has a high incidence in certain regions. This study aimed to address how EBV ... from Cancer via ola Kala on Inoreader http://ift.tt/1Yjza6B via IFTTT
Late Pseudoprogression in glioblastoma: diagnostic value of dynamic O-(2-[18F]fluoroethyl)-L-tyrosine PET
Purpose: Pseudoprogression (PsP) is characterized by therapy-associated but not tumor growth-associated increases of contrast-enhancing glioblastoma lesions on MRI. Although typically occurring during the first 3 months after radiochemotherapy (RCX), PsP may occur later in the course of the disease and may then be particularly difficult to distinguish from true tumor progression. We explored PET using O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET-PET) to approach the diagnostic dilemma. Experimental Design: Twenty-six patients with glioblastoma that presented with increasing contrast... περισσότερα »
A novel crizotinib-resistant solvent-front mutation responsive to cabozantinib therapy in a patient with ROS1-rearranged lung cancer
*Purpose:* Rearranged ROS1 is a crizotinib-sensitive oncogenic driver in lung cancer. The development of acquired resistance, however, poses a serious clinical challenge. Consequently, experimental and clinical validation of resistance mechanisms and potential second-line therapies is essential. *Experimental Design:* We report the discovery of a novel, solvent-front ROS1D2033N mutation in a patient with CD74-ROS1-rearranged lung adenocarcinoma and acquired resistance to crizotinib. Crizotinib-resistance of CD74-ROS1D2033N was functionally evaluated using cell based assays and str...περισσότερα »
The prognostic and predictive value of soluble of type IV collagen in colorectal cancer: A retrospective multicenter study
Purpose: To investigate the prognostic and predictive biomarker value of type IV collagen in colorectal cancer (CRC). Experimental Design: Retrospective evaluation of two independent cohorts of CRC patients included prospectively in 2004-2005 (training set) and 2006-2008 (validation set). Plasma samples were available from 297 (training set) and 482 (validation set) patients. Type IV collagen determinations were performed using an ELISA. From the training set, 222 tumors were available for immunohistochemistry. Clinical and follow-up data were retrieved from patient files and nati... περισσότερα »
Personalized pre-clinical trials in BRAF inhibitor resistant patient derived xenograft models identify second line combination therapies
Purpose: To test second-line personalized medicine combination therapies, based on genomic and proteomic data, in patient-derived xenograft (PDX) models. Methods: We established 12 PDX from BRAF inhibitor progressed melanoma patients. Following expansion, PDX were analyzed using targeted sequencing and reverse phase protein arrays (RPPA). By using multi-arm pre-clinical trial designs, we identified efficacious precision medicine approaches. Results: We identified alterations previously described as drivers of resistance: NRAS mutations in 3 PDX, MAP2K1 (MEK1) mutations in 2, BRAF ... περισσότερα »
A Downward Trend of the Ratio of Influenza RNA Copy Number to Infectious Viral Titer in Hospitalized Influenza A-Infected Patients
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Background. Efficacy endpoints in influenza clinical trials may include clinical symptoms and virological measurements, although virology cannot serve as the primary endpoint. We investigated the relationship between influenza A RNA copy number and quantity of infectious viruses in hospitalized influenza patients. Methods. One hundred fifty influenza-infected, hospitalized patients were included in this prospective cohort study […]
Late Pseudoprogression in glioblastoma: diagnostic value of dynamic O-(2-18Ffluoroethyl)-L-tyrosine PET
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Purpose: Pseudoprogression (PsP) is characterized by therapy-associated but not tumor growth-associated increases of contrast-enhancing glioblastoma lesions on MRI. Although typically occurring during the first 3 months after radiochemotherapy (RCX), PsP may occur later in the course of the disease and may then be particularly difficult to distinguish from true tumor progression. We explored PET using […]
Late Pseudoprogression in glioblastoma: diagnostic value of dynamic O-(2-18Ffluoroethyl)-L-tyrosine PET
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Purpose: Pseudoprogression (PsP) is characterized by therapy-associated but not tumor growth-associated increases of contrast-enhancing glioblastoma lesions on MRI. Although typically occurring during the first 3 months after radiochemotherapy (RCX), PsP may occur later in the course of the disease and may then be particularly difficult to distinguish from true tumor progression. We explored PET using […]
A novel crizotinib-resistant solvent-front mutation responsive to cabozantinib therapy in a patient with ROS1-rearranged lung cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Purpose: Rearranged ROS1 is a crizotinib-sensitive oncogenic driver in lung cancer. The development of acquired resistance, however, poses a serious clinical challenge. Consequently, experimental and clinical validation of resistance mechanisms and potential second-line therapies is essential. Experimental Design: We report the discovery of a novel, solvent-front ROS1D2033N mutation in a patient with CD74-ROS1-rearranged lung adenocarcinoma […]
Treatment of hydrofluoric acid burns of the fingers
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα
With great interest, we read the article published by Kim and colleagues, who reported their experience treating a 33-year-old man with thumb hydrofluoric acid burns using free flap reconstruction in the early stage.1 We appreciate the authors’ superb microsurgery technique. However, we have some concerns regarding the treatment and management of this patient. from #Medicine-SfakianakisAlexandros […]
Full-Thickness Skin Burn Caused by Radiofrequency Ablation of a Benign Thyroid Nodule
Thyroid , Vol. 0, No. 0. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1P8r0pX via IFTTT
Bethesda Categorization of Thyroid Nodule Cytology and Prediction of Thyroid Cancer Type and Prognosis
Thyroid , Vol. 0, No. 0. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1m97a3X via IFTTT
A useful option to obtain maximal foreign body removal and better prognosis in high pressure injection injuries: Negative pressure wound therapy with instillation
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
None declared. from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1T2JZTU via IFTTT
Currently known risk factors for hypertrophic skin scarring: A review
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
To provide an overview of risk factors for hypertrophic scarring. from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1lRzusf via IFTTT
Treatment of hydrofluoric acid burns of the fingers
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
With great interest, we read the article published by Kim and colleagues, who reported their experience treating a 33-year-old man with thumb hydrofluoric acid burns using free flap reconstruction in the early stage.1 We appreciate the authors’ superb microsurgery technique. However, we have some concerns regarding the treatment and management of this patient. from Aesthetic […]
Pedicled distal phalanx fillet flap for finger length preservation in trauma
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Lawnmower injuries to the digits are becoming increasingly common and are often complex in nature with multiple levels of injury. The management of these injuries as with that of other hand injuries is often tailored to the individual patient considering factors such as occupation and hobbies with the ultimate goal of restoration of function and […]
Results of combined vascular reconstruction by means of AV-Loops and free flap transfer in patients with soft tissue defects
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Free flap transplantation to vascular reconstructions as arteriovenous loops and has been established in centers as a feasible therapeutic option for defect reconstruction in absence of proper recipient vessels, caused by oncologic resections, radiation or trauma. We report our 10-years experience in free flap transplantation after vascular reconstruction with special emphasis on complication rate and […]
A comparison of long-term cost and clinical outcomes between the two-stage sequence expansor/prosthesis and autologous deep inferior epigastric flap methods for breast reconstruction in a public hospital
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Postmastectomy breast reconstruction involves the use of large amounts of hospital resources. This study provides comparative data on the clinical results and long-term economic costs of two methods of breast reconstruction in a public hospital. from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1lRzsAC via IFTTT
Impact of the number of veins repaired in short-term digital replantation survival rate
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Venous congestion/insufficiency plays a major role in failure of finger replantation. Despite acceptable salvage rates with postoperative anticoagulation or leeching, operative technique remains the most important predictor of success. However, there are no indications in the literature on the benefit of anastomosing single versus multiple veins. from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1T2JVUj via […]
“Pelvic-Perineal Reconstruction with the Combined Transverse Upper Gracilis and Profunda Artery Perforator (TUG-PAP) Flap”
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
None of the authors received any funds or has any financial interests to disclose. from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1lRzp80 via IFTTT
Volpara as a measurement tool for breast volume
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
None of the authors has a financial interest in any of the products, devices, or drugs mentioned in this manuscript. from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1T2JYiE via IFTTT
Assessment of sural flap microcirculation: Which position maintains the optimal perfusion?
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Limb elevation is a common practice to reduce edema and to increase venous drainage. Considering the anatomy of the sural flap with retrograde perfusion and hence potentially difficult blood outflow, the best angle to positioning the leg following operation is not yet known. from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1lRzqsw via IFTTT
Therapeutic management of complex anal fistulas by installing a nitinol closure clip: study protocol of a multicentric randomised controlled trial–FISCLOSE
Introduction Complex anal fistulas are responsible for pain, faecal incontinence and impaired quality of life. The rectal mucosa advancement flap (RMAF) procedure to cover the internal opening of the fistula remains a strategy of choice. However, a new procedure for closing anal fistulas is now available with the use of a nitinol closure clip (OTSC Proctology, OVESCO), which should ensure a better healing rate. This procedure is currently becoming more widespread, though without robust scientific validation, and it is therefore essential to carry out a prospective evaluation in or... περισσότερα »
Impact of geography on the control of type 2 diabetes mellitus: a review of geocoded clinical data from general practice
Objective To review the clinical data for people with diabetes mellitus with reference to their location and clinical care in a general practice in Australia. Materials and methods Patient data were extracted from a general practice in Western Australia. Iterative data-cleansing steps were taken. Data were grouped into Statistical Area level 1 (SA1), designated as the smallest geographical area associated with the Census of Population and Housing. The data were analysed to identify if SA1s with people aged 70 years and older, and with relatively high glycosylated haemoglobin (Hb... περισσότερα »
Protocol for a mixed-methods longitudinal study to identify factors influencing return to work in the over 50s participating in the UK Work Programme: Supporting Older People into Employment (SOPIE)
Introduction Increasing employment among older workers is a policy priority given the increase in life expectancy and the drop in labour force participation after the age of 50. Reasons for this drop are complex but include poor health, age discrimination, inadequate skills/qualifications and caring roles; however, limited evidence exists on how best to support this group back to work. The Work Programme is the UK Government's flagship policy to facilitate return to work (RTW) among those at risk of long-term unemployment. 'Supporting Older People Into Employment' (SOPIE) is a mi... περισσότερα »
Information resources to aid parental decision-making on when to seek medical care for their acutely sick child: a narrative systematic review
Objective To identify the effectiveness of information resources to help parents decide when to seek medical care for an acutely sick child under 5 years of age, including the identification of factors influencing effectiveness, by systematically reviewing the literature. Methods 5 databases and 5 websites were systematically searched using a combination of terms on children, parents, education, acute childhood illness. A narrative approach, assessing quality via the Mixed Methods Appraisal Tool, was used due to non-comparable research designs. Results 22 studies met the inclus... περισσότερα »
Pathology and oncology in Africa: education and training for the future in cancer research– East African Regional Meeting
According to the World Health Organisation (WHO), deaths from non-communicable diseases (NCDs) will increase globally, with the largest increase being on the African continent. On our continent, projections have indicated that deaths from NCDs will exceed all combined communicable, maternal, perinatal and nutritional diseases as the most common causes of death by 2030. Hence, the importance of a functional and improved pathology system in the diagnosis of cancer cannot be debated.Recently, the African Organization for Research and Training in Cancer (AORTIC) organised its East Afr...περισσότερα »
Prof Nigel Bundred gives an update on breast-conserving surgery at #SABCS15 https://t.co/ko3a7Ptxut @OfficialUoM
Prof Nigel Bundred gives an update on breast-conserving surgery at #SABCS15 https://t.co/ko3a7Ptxut @OfficialUoM from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/677319087882674180 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2296fSg via IFTTT
MR imaging of ovarian masses: classification and differential diagnosis
Abstract Objective We propose a Magnetic Resonance Imaging (MRI) guided approach to differential diagnosis of ovarian tumours based on morphological appearance. Background Characterization of ovarian lesions is of great importance in order to plan adequate therapeutic procedures, and may influence patient's management. Optimal assessment of adnexal masses requires a multidisciplinary approach, based on physical examination, laboratory tests and imaging techniques. Primary ovarian tumours can be classified into three main categories according to tumour origin: epithelial, germ cell...περισσότερα »
Belen Rodriguez presenterà il nuovo programma Pequenos Gigantes con Stefano De Martino – LeiChic (Blog)
[image: 1JdfTYo] LeiChic (Blog) *Belen Rodriguez presenterà il nuovo programma Pequenos Gigantes con Stefano De Martino* *LeiChic (Blog)* Belen Rodriguez *è* la showgirl argentina più discussa *e* criticata degli ultimi anni che nonostante questo *è* sempre riuscita ad andare avanti a *testa* alta senza mai farsi abbattere. Anche questa volta il pubblico ha cercato *di* abbatterla pensando che la *…* Incognita per 654 mila contratti a progettoMetro *all 116 news articles »* from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1O9EC7l via IFTTT from #Med Bl...περισσότερα »
Comparison of tooth-borne and hybrid devices in surgically assisted rapid maxillary expansion: a randomized clinical cone-beam computed tomography study
The objective of this 2-arm, parallel, single-center trial was to compare the skeletal, dental, and periodontal effects of tooth-borne (TB) and hybrid devices in surgically assisted rapid maxillary expansion (SARME). from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1NqzMyV via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TRgMv6 via IFTTT
A clinical study of the outcomes and complications associated with zygomatic buttress block bone graft for limited preimplant augmentation procedures
The aim of this study was to evaluate the possibility of using the zygomatic buttress as an intraoral bone harvesting donor site and determine the safety of this harvesting procedure for later optimal positioning of dental implants in accordance with prosthodontic and functional principles. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1NqzOqI via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2296hto via IFTTT
A novel mutant 10Ala/Arg together with mutant 144Ser/Arg of Hepatitis B virus X protein involved in Hepatitis B Virus-related hepatocarcinogenesis in HepG2 cell lines
• Amino acid residues 10 and 144 of HBx anchored signature sequence in HCC tissues.• A10R-S144R mutation prolonged G1/S transition via regulation of cell cycle arrest.• A10R/S144R double-mutation decreased Bax expression and inhibited HepG2 apoptosis. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1NUjWya via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TRgJzI via IFTTT
Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro
• Expression of Cathepsin L and CD133 were correlated with human glioma malignancy.• Knockdown of Cathepsin L leads to radiosensitization in GSCs.• The improved radiosensitivity was through stemness, DNA repair, and apoptosis.• Knockdown of Cathepsin L exhibited less tumor growth after radiation in vivo.• Cathepsin L is a promising therapeutic target for clinical therapy in GBM patients. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1P8hW4g via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt...περισσότερα »
B-Cell Disorders and Curcumin
Clinical studies with patients with early hematological malignancies (ie, monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, or stage 0/1 chronic lymphocytic leukemia) suggest that early intervention with curcumin, derived from the spice turmeric, may lead to prolonged survival and delay in progressive disease in some of these patients. from Cancer via ola Kala on Inoreader http://ift.tt/1O9yV9B via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mp5HqX via IFTTT
Subkutanes pannikulitisartiges T-Zell-Lymphom
Zusammenfassung Bei 2 Patientinnen im Alter von 44 und 70 Jahren konnte nach klinisch-histopathologischer und molekularbiologischer Korrelation die Diagnose eines subkutanen pannikulitisartigen T-Zell-Lymphoms gestellt werden. Die klinische Morphologie des Lymphoms zeigte eine deutliche Variabilität. Bei einer Patientin fand sich ein singulärer erythematöser Knoten an der Kinnregion, bei der anderen fanden sich ausgedehnte plattenartige Resistenzen und Atrophien im Gesicht, an den Oberarmen und am vorderen Dekolleté. Ein assoziiertes Hämophagozytosesyndrom lag bei beiden Patientin... περισσότερα »
Salivary Biomarkers Associated With Bone Deterioration in Patients With Medication-Related Osteonecrosis of the Jaws
Kolokythas et al1 recently published an interesting article regarding the association of salivary biomarkers with bone deterioration. They suggested that using saliva, rather than serum or urine, could be an alternative for future studies of medication-related osteonecrosis of the jaw. Because it is the first report on the use of saliva for the detection of 2 bone turnover–related biomarkers (NTX and B-AP), a deeper look might be necessary: from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1IVFqKT via IFTTT from #Med Blogs by Alexandros G.Sfakianaki... περισσότερα »
Volpara as a measurement tool for breast volume
None of the authors has a financial interest in any of the products, devices, or drugs mentioned in this manuscript. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1T2JYiE via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Ymeky8 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QqUfrq via IFTTT
“Pelvic-Perineal Reconstruction with the Combined Transverse Upper Gracilis and Profunda Artery Perforator (TUG-PAP) Flap”
None of the authors received any funds or has any financial interests to disclose. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1lRzp80 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1NUlE2D via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Jdea5a via IFTTT
Three historical papers for the septocutaneous perforator flaps of the thigh
Nowadays perforator flaps from the thigh area are frequently used. Despite of its common usage in reconstructions, there are scanty of papers which search for the origin of the perforator flaps of the thigh in historical perspective. This paper attempted to compare the three historical papers of the septocutaneous perforator flaps of the thigh. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1lRzo3X via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1NUlE2v via IFTTT from #Med Blogs by Alexandros ...περισσότερα »
Assessment of sural flap microcirculation: Which position maintains the optimal perfusion?
Limb elevation is a common practice to reduce edema and to increase venous drainage. Considering the anatomy of the sural flap with retrograde perfusion and hence potentially difficult blood outflow, the best angle to positioning the leg following operation is not yet known. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1lRzqsw via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1NUlE2x via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1... περισσότερα »
Complication rates in Sentinel Lymph Node Biopsy for Melanoma
Malignant melanoma is the 5th most common cancer in the UK, with 12, 818 new cases diagnosed in 2010 [1]. Surgery remains fundamental to treatment. Sentinel lymph node biopsy (SLNB) is indicated for those patients with a clinically negative nodal basin and a primary melanoma with a Breslow thickness of >1mm. The evidence for Completion Lymph Node Dissection (CLND) is under review with the final results of MSLT II available in 2022. Complication rates in the literature range between 5-10% [2-3]. The authors aimed to ascertain the risk of complications following SLNB in a regional u...περισσότερα »
Results of combined vascular reconstruction by means of AV-Loops and free flap transfer in patients with soft tissue defects
Free flap transplantation to vascular reconstructions as arteriovenous loops and has been established in centers as a feasible therapeutic option for defect reconstruction in absence of proper recipient vessels, caused by oncologic resections, radiation or trauma. We report our 10-years experience in free flap transplantation after vascular reconstruction with special emphasis on complication rate and postoperative mobility. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1T2JZ6l via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.... περισσότερα »
Appuntamenti – Prevenire la corrosione nel comparto Oil & Gas – Tecn’èLAB
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Appuntamenti – Prevenire la corrosione nel comparto Oil & Gas Tecn’èLAB L’appuntamento internazionale ospiterà esperti provenienti da tutto il mondo per presentare e discutere i più recenti progressi delle conoscenze e delle tecnologie per la prevenzione della corrosione in relazione all’ambiente, alla salute e alla … from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1MimKzy via IFTTT
A Downward Trend of the Ratio of Influenza RNA Copy Number to Infectious Viral Titer in Hospitalized Influenza A-Infected Patients
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background. Efficacy endpoints in influenza clinical trials may include clinical symptoms and virological measurements, although virology cannot serve as the primary endpoint. We investigated the relationship between influenza A RNA copy number and quantity of infectious viruses in hospitalized influenza patients. Methods. One hundred fifty influenza-infected, hospitalized patients were included in this prospective cohort study […]
Toowoomba surgeon performs final operation in 41-year career – ABC Local
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
ABC Local Toowoomba surgeon performs final operation in 41-year career ABC Local «Parents will tell their child, ‘This is the doctor that took my tonsils out’. And that … Dr Harrington said he had noticed a decline in the number of throat cancer patients, and put it down to falling smoking rates, which he said […]
Relationship Quality Among Cohabiting Versus Married Couples
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Using data from the nationally representative 2010 Married and Cohabiting Couples Survey of different-sex cohabiting and married couples, we compared the relationship quality of today’s cohabitors and marrieds. Consistent with diffusion theory and recent conceptual work on the deinstitutionalization of marriage, we found that the relationship between union type and relationship quality is now bifurcated […]
The Return of Superman? Individual and Organizational Predictors of Mens Housework in South Korea
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
In this survey study, we investigate factors that predict the extent of men’s engagement in housework in South Korea. Using data collected from 466 working fathers during the period from March 2013 to August 2013, it was found that a more egalitarian gender ideology and supervisor support for work–family balance were significant predictors of the […]
Correlation between symptoms and objective findings may improve the symptom-based diagnosis of chronic rhinosinusitis for primary care and epidemiological studies
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background In primary care and epidemiological studies of chronic rhinosinusitis (CRS), symptom-based diagnosis is common, yet limited, because endoscopic and radiological signs are not considered. Objectives To evaluate the correlation between symptoms and objective findings of CRS to improve its symptom-based diagnosis for primary care and epidemiological studies by using data from a large-scale nationwide […]
Identifying research priorities in anaesthesia and perioperative care: final report of the joint National Institute of Academic Anaesthesia/James Lind Alliance Research Priority Setting Partnership
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Objective To identify research priorities for Anaesthesia and Perioperative Medicine. Design Prospective surveys and consensus meetings guided by an independent adviser. Setting UK. Participants 45 stakeholder organisations (25 professional, 20 patient/carer) affiliated as James Lind Alliance partners. Outcomes First ‘ideas-gathering’ survey: Free text research ideas and suggestions. Second ‘prioritisation’ survey: Shortlist of ‘summary’ research questions […]
MAGnesium-oral supplementation to reduce PAin in patients with severe PERipheral arterial occlusive disease: the MAG-PAPER randomised clinical trial protocol
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Introduction Magnesium exerts analgaesic effects in several animal pain models, as well as in patients affected by acute postoperative pain and neuropathic chronic pain. There is no evidence that magnesium can modulate pain in patients with peripheral arterial occlusive disease (PAOD). We describe the protocol of a single-centre randomised double-blind clinical trial aimed at assessing […]
Survey of the capacity for essential surgery and anaesthesia services in Papua New Guinea
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Objective To assess capacity to provide essential surgical services including emergency, obstetric and anaesthesia care in Papua New Guinea (PNG) in order to support planning for relevant post-2015 sustainable development goals for PNG. Design Cross-sectional survey. Setting Hospitals and health facilities in PNG. Participants 21 facilities including 3 national/provincial hospitals, 11 district/rural hospitals, and 7 […]
Exercise Programme in Endometrial Cancer; Protocol of the Feasibility and Acceptability Survivorship Trial (EPEC-FAST)
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Introduction Obesity has been associated with impaired quality of life and poorer outcomes in endometrial cancer survivors. Lifestyle interventions promoting exercise and weight reduction have been proposed for survivorship care. However, studies evaluating exercise programmes for endometrial cancer survivors are lacking. Purpose The objective of this study is to evaluate the feasibility of an individualised […]
Nightmare sufferers show atypical emotional semantic associations and prolonged REM sleep-dependent emotional priming
• NM subjects have uncommon emotional semantic associations.• REM naps lead to restricted breadth of associations for primed negative cue-words.• REM naps lead to increased breadth of associations for primed positive cue-words.• After one week, CTL group no longer shows altered semantic access for primed words.• NM sufferers retain their priming effect at one week …
A clinical study of the outcomes and complications associated with zygomatic buttress block bone graft for limited preimplant augmentation procedures
The aim of this study was to evaluate the possibility of using the zygomatic buttress as an intraoral bone harvesting donor site and determine the safety of this harvesting procedure for later optimal positioning of dental implants in accordance with prosthodontic and functional principles. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1NqzOqI via IFTTT
Full-Thickness Skin Burn Caused by Radiofrequency Ablation of a Benign Thyroid Nodule
Thyroid , Vol. 0, No. 0. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1YmjLx5 via IFTTT
Bethesda Categorization of Thyroid Nodule Cytology and Prediction of Thyroid Cancer Type and Prognosis
Thyroid , Vol. 0, No. 0. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1NyvEuG via IFTTT
Full-Thickness Skin Burn Caused by Radiofrequency Ablation of a Benign Thyroid Nodule
Thyroid , Vol. 0, No. 0. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1YmjLx5 via IFTTT
Bethesda Categorization of Thyroid Nodule Cytology and Prediction of Thyroid Cancer Type and Prognosis
Thyroid , Vol. 0, No. 0. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1NyvEuG via IFTTT
Melissa Bishop says she’s stronger because of coach’s partnership – Windsor Star
Windsor Star Melissa Bishop says she’s stronger because of coach’s partnership Windsor Star After beating cancer of the larynx, the 62-year-old was diagnosed two years ago with progressive supranuclear palsy — PSP — a degenerative condition that results from deterioration of cells in the brain that control body movement and thinking. It has … and …
Salivary Biomarkers Associated With Bone Deterioration in Patients With Medication-Related Osteonecrosis of the Jaws
Kolokythas et al1 recently published an interesting article regarding the association of salivary biomarkers with bone deterioration. They suggested that using saliva, rather than serum or urine, could be an alternative for future studies of medication-related osteonecrosis of the jaw. Because it is the first report on the use of saliva for the detection of …
A useful option to obtain maximal foreign body removal and better prognosis in high pressure injection injuries: Negative pressure wound therapy with instillation
None declared. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1T2JZTU via IFTTT
Currently known risk factors for hypertrophic skin scarring: A review
To provide an overview of risk factors for hypertrophic scarring. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1lRzusf via IFTTT
From the Editor-in-Chief's Desk
Journal of Adolescent and Young Adult Oncology Dec 2015, Vol. 4, No. 4: 151-151. from Cancer via ola Kala on Inoreader http://ift.tt/1lRQr5V via IFTTT
A single nucleotide polymorphism in the Epstein-Barr virus genome is strongly associated with a high risk of nasopharyngeal carcinoma
Abstract Background Epstein-Barr virus (EBV) commonly infects the general population and has been associated with nasopharyngeal carcinoma (NPC), which has a high incidence in certain regions. This study aimed to address how EBV variations contribute to the risk of NPC. Methods Using logistic regression analysis and based on the sequence variations at EBV-encoded *RPMS1*, a multi-stage association study was conducted to identify EBV variations associated with NPC risk. A protein degradation assay was performed to characterize the functional relevance of the *RPMS1* variations. Re...περισσότερα »
Impact of the number of veins repaired in short-term digital replantation survival rate
Venous congestion/insufficiency plays a major role in failure of finger replantation. Despite acceptable salvage rates with postoperative anticoagulation or leeching, operative technique remains the most important predictor of success. However, there are no indications in the literature on the benefit of anastomosing single versus multiple veins. from #Head and Neck by Sfakianakis via simeraentaxei on …
“Pelvic-Perineal Reconstruction with the Combined Transverse Upper Gracilis and Profunda Artery Perforator (TUG-PAP) Flap”
None of the authors received any funds or has any financial interests to disclose. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1lRzp80 via IFTTT
Volpara as a measurement tool for breast volume
None of the authors has a financial interest in any of the products, devices, or drugs mentioned in this manuscript. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1T2JYiE via IFTTT
Assessment of sural flap microcirculation: Which position maintains the optimal perfusion?
Limb elevation is a common practice to reduce edema and to increase venous drainage. Considering the anatomy of the sural flap with retrograde perfusion and hence potentially difficult blood outflow, the best angle to positioning the leg following operation is not yet known. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1lRzqsw via …
Complication rates in Sentinel Lymph Node Biopsy for Melanoma
Malignant melanoma is the 5th most common cancer in the UK, with 12, 818 new cases diagnosed in 2010 [1]. Surgery remains fundamental to treatment. Sentinel lymph node biopsy (SLNB) is indicated for those patients with a clinically negative nodal basin and a primary melanoma with a Breslow thickness of >1mm. The evidence for Completion …
Three historical papers for the septocutaneous perforator flaps of the thigh
Nowadays perforator flaps from the thigh area are frequently used. Despite of its common usage in reconstructions, there are scanty of papers which search for the origin of the perforator flaps of the thigh in historical perspective. This paper attempted to compare the three historical papers of the septocutaneous perforator flaps of the thigh. from …
Salivary Biomarkers Associated With Bone Deterioration in Patients With Medication-Related Osteonecrosis of the Jaws
Kolokythas et al1 recently published an interesting article regarding the association of salivary biomarkers with bone deterioration. They suggested that using saliva, rather than serum or urine, could be an alternative for future studies of medication-related osteonecrosis of the jaw. Because it is the first report on the use of saliva for the detection of …
Treatment of hydrofluoric acid burns of the fingers
With great interest, we read the article published by Kim and colleagues, who reported their experience treating a 33-year-old man with thumb hydrofluoric acid burns using free flap reconstruction in the early stage.1 We appreciate the authors' superb microsurgery technique. However, we have some concerns regarding the treatment and management of this patient. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1T2JZn0 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TRcSTe via IFTTT from #M... περισσότερα »
Pedicled distal phalanx fillet flap for finger length preservation in trauma
Lawnmower injuries to the digits are becoming increasingly common and are often complex in nature with multiple levels of injury. The management of these injuries as with that of other hand injuries is often tailored to the individual patient considering factors such as occupation and hobbies with the ultimate goal of restoration of function and a sensate fingertip.The concept of using amputated, mangled or non-salvageable parts in a form of fillet flap has become more common in the recent years. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lRztE... περισσότερα »
Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro
• Expression of Cathepsin L and CD133 were correlated with human glioma malignancy.• Knockdown of Cathepsin L leads to radiosensitization in GSCs.• The improved radiosensitivity was through stemness, DNA repair, and apoptosis.• Knockdown of Cathepsin L exhibited less tumor growth after radiation in vivo.• Cathepsin L is a promising therapeutic target for clinical therapy in GBM patients. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1P8hW4g via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/...περισσότερα »
Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro
• Expression of Cathepsin L and CD133 were correlated with human glioma malignancy.• Knockdown of Cathepsin L leads to radiosensitization in GSCs.• The improved radiosensitivity was through stemness, DNA repair, and apoptosis.• Knockdown of Cathepsin L exhibited less tumor growth after radiation in vivo.• Cathepsin L is a promising therapeutic target for clinical therapy in GBM patients. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1P8hW4g via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt...περισσότερα »
A novel mutant 10Ala/Arg together with mutant 144Ser/Arg of Hepatitis B virus X protein involved in Hepatitis B Virus-related hepatocarcinogenesis in HepG2 cell lines
• Amino acid residues 10 and 144 of HBx anchored signature sequence in HCC tissues.• A10R-S144R mutation prolonged G1/S transition via regulation of cell cycle arrest.• A10R/S144R double-mutation decreased Bax expression and inhibited HepG2 apoptosis. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1NUjWya via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UC8Vmm via IFTTT
B-Cell Disorders and Curcumin
Clinical studies with patients with early hematological malignancies (ie, monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, or stage 0/1 chronic lymphocytic leukemia) suggest that early intervention with curcumin, derived from the spice turmeric, may lead to prolonged survival and delay in progressive disease in some of these patients. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1O9yV9B via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TRcfcb via IFTTT
Early breast cancer: Window of opportunity between diagnosis and treatment https://t.co/pICXoKU8De #SABCS15
Early breast cancer: Window of opportunity between diagnosis and treatment https://t.co/pICXoKU8De #SABCS15 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/677303989860483072 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UC8TuH via IFTTT
The Pharmacological Costs of TKIs in First-Line for Advanced NSCLC Patients with Activating EGFR-Mutations: A Review of Pivotal Phase III RCTs
Many driver mutations that determine the malignant behavior of lung cancer have been identified in recent years 1. The epidermal growth factor receptor (EGFR) signaling pathway is crucial for regulating tumorigenesis and cell survival and may be important in the development and progression of non-small cell lung cancer (NSCLC) 2. Activating mutation in exons 19 or 21 of EGFR in NSCLC are associated with increased sensitivity to EGFR-tyrosne kinase inhibitors (TKIs) 3. The 2nd ESMO Consensus Conference on Lung Cancer 3 has recommended that an EGFR TKI is the preferred first-line tr...περισσότερα »
Sonic Hedgehog pathway activation is associated with resistance to platinum-based chemotherapy in advanced non-small cell lung carcinoma
Chemoresistance is a major challenge in the treatment of advanced non-small cell lung cancer (NSCLC). As the Sonic Hedgehog (Shh) pathway is reactivated in NSCLC, we investigated an association between chemoresistance and Shh activation. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1P9upqx via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UC8Vme via IFTTT
Results of a phase II trial of carboplatin, pemetrexed and bevacizumab for the Treatment of never or former/light smoking patients with stage IV NSCLC
We studied first line treatment of stage IV NSCLC with carboplatin, Pemetrexed and bevacizumab. We found a median PFS of 12.6 months, ORR of 47% and median OS of 20.3 months. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1P9upa0 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QO1h7T via IFTTT
First-line pemetrexed plus cisplatin followed by gefitinib maintenance therapy versus gefitinib monotherapy in East Asian never-smoker patients with locally advanced or metastatic nonsquamous non-small cell lung cancer: Quality of life results from a randomized phase 3 trial
In a randomized study of pemetrexed plus cisplatin followed by maintenance gefitinib (PC/G) or gefitinib monotherapy (G) in East Asian never-smoker patients with advanced nonsquamous non-small cell lung cancer, quality of life symptoms were more favorable in the G than PC/G group. In patients with wild-type epidermal growth factor receptor, tumor-related symptoms appeared to improve more with PC/G than G. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1P9upGS via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inore...περισσότερα »
A Randomized multicenter phase III study of single-administration of mecapegfilgrastim (HHPG-19K), a pegfilgrastim biosimilar, for prophylaxis of chemotherapy-induced neutropenia in patients with advanced non-small cell lung cancer (NSCLC)
The efficacy and safety profile of mecapegfilgrastim as prophylactic use among NSCLC patients in this two-stage study. From the double-blind stage and open label stage, not only the efficacy comparing mecapegfilgrastim and short action G-CSF was explored, but also the exact incidence of neutropenia and FN in this population was well studied. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1k3SAcV via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QO1gRz via IFTTT
Immunohistochemical expression of K6, K8, K16, K17, K19, Maspin, Syndecan-1 (CD138), α-SMA and Ki-67 in amelob lastoma and ameloblastic carcinoma: diagnostic and prognostic correlations
To identify cut off values of markers that correlate with the histopathologic diagnosis of ameloblastic carcinoma (AC) and/or the increased recurrence potential of ameloblastoma (AB). from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1QtKqZB via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UC8V5V via IFTTT
CBCT constancy controls: How user-friendly is the new phantom?
In 2014 we presented a new phantom and software for simplified image quality assurance (IQA) controls of dental cone beam computed tomography units (CBCT)1. We received some comments concerning if the phantom and software are adapted to their purpose, which led us to conduct a pilot study to assess their user- friendliness for IQA constancy controls performed by clinical staff2. The EU guidelines on the use of CBCT3 states in its Basic Principles that "a quality assurance programme must be established and implemented for each CBCT facility, including equipment, techniques and qual...περισσότερα »
Objective validity of an implant-retained overdenture with a ball attachment system after marginal mandibulectomy
Implant-retained overdentures are known to improve oral function, but the clinical impact on patients who have had mandibular resections is still debatable. We have treated 16 patients who had such resections for oral cancer and consequent loss of the alveolar ridge, with overdentures supported by osseointegrated implants and ball attachments. To quantify their functional improvement, we evaluated their maximum bite force and masticatory performance. Their function improved significantly, (from 77.5N – 365N, 371% increase in maximum bite force, p<0.001) and masticatory performance... περισσότερα »
Percutaneous sclerotherapy of arteriovenous malformations of the face using fibrin glue combined with OK-432 and bleomycin after embolisation
Congenital arteriovenous malformations (AVM) in the maxillofacial region are rare, but potentially life-threatening, vascular lesions. Here we review our experience of 13 patients with AVM of the facial soft tissues who were treated using percutaneous sclerotherapy with fibrin glue combined with OK-432 and bleomycin after embolisation. The mean (range) follow-up was 27 (14-58) months. Three of the lesions were completely controlled, eight were nearly completely controlled, and the other two were partly controlled. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader ...περισσότερα »
Influence of preservation of the alveolar ridge on delayed implants after extraction of teeth with different defects in the buccal bone
Our aim was to evaluate the influence of preservation of the alveolar ridge on delayed implants with different defects in the buccal bone. We enrolled 60 patients who had one posterior mandibular tooth extracted. Cone-beam computed tomography (CT) was used to measure the buccal bone defects in the alveolar ridge before the tooth was extracted (level A=3 to 5mm, and level B=more than 5mm). After the tooth had been extracted, the socket either had the alveolar ridge preserved (trial group) or it was left to heal spontaneously (control group). from #Head and Neck by Sfakianakis via s... περισσότερα »
Award-Winning Study of High-Risk Head & Neck Patients Documents Key Role for … – LWW Journals
*Award-Winning Study of High-Risk Head & Neck Patients Documents Key Role for …* *LWW Journals* SAN ANTONIO—For *head and neck cancer* patients at high-risk for adverse events after chemoradiotherapy, more frequent follow-up appointments in an outpatient clinic led by advanced practice nurses (APNs) resulted in fewer post-treatment emergency … from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1NUbD5z via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QO1gRm via IFTTT
Pedicled distal phalanx fillet flap for finger length preservation in trauma
Lawnmower injuries to the digits are becoming increasingly common and are often complex in nature with multiple levels of injury. The management of these injuries as with that of other hand injuries is often tailored to the individual patient considering factors such as occupation and hobbies with the ultimate goal of restoration of function and a sensate fingertip.The concept of using amputated, mangled or non-salvageable parts in a form of fillet flap has become more common in the recent years. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lRztE... περισσότερα »
Carcinoma Cuniculatum of the Foot Invading the Bone Mimicking a Pseudo-Epitheliomatous Reaction to an Acute Osteomyelitis
Abstract Carcinoma cuniculatum is a rare variant of squamous cell carcinoma. The clinical presentation is usually a non-verrucous exophytic plaque or tumor of the plantar region with a penetration in the deep tissues. Histological examination shows a proliferation of well-differentiated keratinocytes. We describe a patient affected by a slowly enlarging tumoral lesion overlying the fifth metatarsum of the left foot. Clinical examination and radiological investigations suggested a chronic osteomyelitis and a first histological examination of a punch biopsy was suggestive of a pseud... περισσότερα »
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