Suppression of Cancer Metastasis to Brain by Penfluridol
In Vivo Suppression of Breast Cancer Metastasis to Brain by Penfluridol: Metastasis of breast cancer, especially to the brain, is the major cause of mortality. The inability of anticancer agents to cross the blood-brain-barrier represents a critical challenge for successful treatment. In the current study, we investigated the antimetastatic potential of penfluridol, an antipsychotic drug frequently prescribed for schizophrenia with anticancer activity. We show that penfluridol induced apoptosis and reduced the survival of several metastatic triple-negative breast cancer (TNBC) cell ... περισσότερα »
Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic skin fragility disorder characterized by injury-driven blister formation, progressive soft-tissue fibrosis, and a highly elevated risk of early-onset aggressive cutaneous squamous cell carcinoma (cSCC)
Injury-Driven Dermal Stiffness Drives cSCC: Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic skin fragility disorder characterized by injury-driven blister formation, progressive soft-tissue fibrosis, and a highly elevated risk of early-onset aggressive cutaneous squamous cell carcinoma (cSCC). However, the mechanisms underlying the unusually rapid progression of RDEB to cSCC are unknown. In this study, we investigated the contribution of injury-induced skin alterations to cSCC development by using a genetic model of RDEB and organotypic skin cultures. Analysis of RDEB... περισσότερα »
CD74-NRG1 Fusion Gene Product Confers Cancer Stem Cell Properties
CD74-NRG1 Fusion Gene Product Confers Cancer Stem Cell Properties: The CD74-Neuregulin1 (NRG1) fusion gene was recently identified as novel driver of invasive mucinous adenocarcinoma, a malignant form of lung cancer. However, the function of the CD74-NRG1 fusion gene in adenocarcinoma pathogenesis and the mechanisms by which it may impart protumorigenic characteristics to cancer stem cells (CSC) is still unclear. In this study, we found that the expression of the CD74-NRG1 fusion gene increased the population of lung cancer cells with CSC-like properties. CD74-NRG1 expression facili... περισσότερα »
Targeting mTOR Mutations in Melanoma
Targeting mTOR Mutations in Melanoma: *Purpose:* mTOR is a validated target in cancer. It remains to be determined whether melanoma patients bearing *mTOR* mutation could be selected for treatment with PI3K–AKT–mTOR pathway inhibitors. *Experimental Design:* A total of 412 melanoma samples were included. Gene aberrations in all exons of *mTOR* were detected by Sanger sequencing and confirmed by using Agilent's SureSelect Target Enrichment System. HEK293T cells stably expressing mTOR mutants were constructed by using transcription activator-like effector nucleases technique. Functio... περισσότερα »
Lumretuzumab in Solid Tumors
Lumretuzumab in Solid Tumors: *Purpose:* A first-in-human phase I study was conducted to characterize safety, efficacy, and pharmacokinetic (PK) and pharmacodynamic (PD) properties of lumretuzumab, a humanized and glycoengineered anti-HER3 monoclonal antibody, in patients with advanced cancer. *Experimental Design:* Twenty-five patients with histologically confirmed HER3-expressing tumors received lumretuzumab (100, 200, 400, 800, 1,600, and 2,000 mg) every two weeks (q2w) in 3+3 dose-escalation phase. In addition, 22 patients were enrolled into an extension cohort at 2,000 mg q2w... περισσότερα »
Proapoptotic Drugs
Pharmacodynamic Monitoring of Proapoptotic Drugs: *Purpose:* To support clinical pharmacodynamic evaluation of the Smac mimetic TL32711 (birinapant) and other apoptosis-targeting drugs, we describe the development, validation, and application of novel immunoassays for 15 cytosolic and membrane-associated proteins indicative of the induction, onset, and commitment to apoptosis in human tumors. *Experimental Design:* The multiplex immunoassays were constructed on the Luminex platform with apoptosis biomarkers grouped into three panels. Panel 1 contains Bak, Bax, total caspase-3, tota... περισσότερα »
RG7212 reduced tumor TWEAK–Fn14 signaling in a systemic exposure-dependent manner. In addition to higher exposure, relatively high Fn14 expression might be required for pharmacodynamic effect of anti-TWEAK monoclonal antibodies
Pharmacodynamics of the Anti-TWEAK mAb RG7212: *Purpose:* The TWEAK–Fn14 pathway represents a novel anticancer target that is being actively investigated. Understanding the relationship between pharmacokinetics of anti-TWEAK therapeutics and tumor pharmacodynamics is critical. We investigated exposure-response relationships of RG7212, an anti-TWEAK mAb, in patients with Fn14-expressing tumors. *Experimental Design:* Patients with Fn14-positive tumors (IHC≥1+) treated in a phase I first-in-human study with ascending doses of RG7212 were the basis for this analysis. Pharmacokinetics ... περισσότερα »
Image-Guided Interventions of Head and Neck Cancer
Image-Guided Interventions of Head and Neck Cancer: *Purpose:* The low survival rate of head and neck cancer (HNC) patients is attributable to late disease diagnosis and high recurrence rate. Current HNC staging has inadequate accuracy and low sensitivity for effective diagnosis and treatment management. The multimodal porphyrin lipoprotein-mimicking nanoparticle (PLP), intrinsically capable of positron emission tomography (PET), fluorescence imaging, and photodynamic therapy (PDT), shows great potential to enhance the accuracy of HNC staging and potentially HNC management. *Exper...περισσότερα »
Polymer thick film technology for improved simultaneous dEEG/MRI recording: Safety and MRI data quality
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Purpose To develop a 256-channel dense-array electroencephalography (dEEG) sensor net (the Ink-Net) using high-resistance polymer thick film (PTF) technology to improve safety and data quality during simultaneous dEEG/MRI. Methods Heating safety was assessed with temperature measurements in an anthropomorphic head phantom during a 30-min, induced-heating scan at 7T. MRI quality assessment used B1 field mapping […]
Optimizing the acceleration and resolution of three-dimensional fat image navigators for high-resolution motion correction at 7T
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Purpose To investigate the effect of spatial resolution and parallel imaging acceleration factor on the quality of the motion estimates derived from image navigators with a three-dimensional (3D) gradient-recalled echo (GRE) acquisition with fat excitation (3D FatNavs) for neuroimaging at 7T. Methods Six healthy subjects were scanned for 10 min, during which time repeated GRE volumes […]
Stimulated echo diffusion weighted imaging of the liver at 3 Tesla
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Purpose Diffusion time (Δ) effect in diffusion measurements has been validated as a sensitive biomarker in liver fibrosis by rat models. To extend this finding to clinical study, a reliable imaging technique is highly desirable. This study aimed to develop an optimal stimulated echo acquisition mode (STEAM) diffusion-weighted imaging (DWI) method dedicated to human liver […]
IL6 Trans-signaling Promotes Kras Lung Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Oncogenic KRAS mutations occur frequently in lung adenocarcinoma. The signaling pathways activated by IL6 promote Kras-driven lung tumorigenesis, but the basis for this cooperation is uncertain. In this study, we used the gp130F/F (Il6st) knock-in mouse model to examine the pathogenic contribution of hyperactivation of the STAT3 arm of IL6 signaling on KRAS-driven lung tumorigenesis. […]
miR-34a Shows Tumor Suppressor Functions in TNBC
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Triple-negative breast cancer (TNBC) is an aggressive subtype with no clinically proven biologically targeted treatment options. The molecular heterogeneity of TNBC and lack of high frequency driver mutations other than TP53 have hindered the development of new and effective therapies that significantly improve patient outcomes. miRNAs, global regulators of survival and proliferation pathways important in […]
Wnt Inhibitor LF3
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Wnt/β-catenin signaling is a highly conserved pathway essential for embryogenesis and tissue homeostasis. However, deregulation of this pathway can initiate and promote human malignancies, especially of the colon and head and neck. Therefore, Wnt/β-catenin signaling represents an attractive target for cancer therapy. We performed high-throughput screening using AlphaScreen and ELISA techniques to identify small molecules […]
Role of Macrophages in Wound-Induced Skin Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Macrophages are essential for the progression and maintenance of many cancers, but their role during the earliest stages of tumor formation is unclear. To test this, we used a previously described transgenic mouse model of wound-induced skin tumorigenesis, in which expression of constitutively active MEK1 in differentiating epidermal cells results in chronic inflammation (InvEE mice). […]
Metabolic Biomarkers for Ovarian High-Grade Serous Ovarian Carcinomas
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Ovarian cancer is a heterogeneous disease of low prevalence, but poor survival. Early diagnosis is critical for survival, but it is often challenging because the symptoms of ovarian cancer are subtle and become apparent only during advanced stages of the disease. Therefore, the identification of robust biomarkers of early disease is a clinical priority. Metabolomic […]
Imaging Tumor Hypoxia In Vivo with Oxygen-Enhanced MRI
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
There is a clinical need for noninvasive biomarkers of tumor hypoxia for prognostic and predictive studies, radiotherapy planning, and therapy monitoring. Oxygen-enhanced MRI (OE-MRI) is an emerging imaging technique for quantifying the spatial distribution and extent of tumor oxygen delivery in vivo. In OE-MRI, the longitudinal relaxation rate of protons (ΔR1) changes in proportion to […]
Metabolic Biomarkers for Ovarian High-Grade Serous Ovarian Carcinomas
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Ovarian cancer is a heterogeneous disease of low prevalence, but poor survival. Early diagnosis is critical for survival, but it is often challenging because the symptoms of ovarian cancer are subtle and become apparent only during advanced stages of the disease. Therefore, the identification of robust biomarkers of early disease is a clinical priority. Metabolomic […]
Pevonedistat in Advanced Solid Tumors
Phase I Study of Pevonedistat in Advanced Solid Tumors: *Purpose:* To determine the dose-limiting toxicities (DLTs) and maximum tolerated dose (MTD) of the investigational NEDD8-activating enzyme (NAE) inhibitor pevonedistat (TAK-924/MLN4924) and to investigate pevonedistat pharmacokinetics and pharmacodynamics in patients with advanced nonhematologic malignancies. *Experimental Design:* Pevonedistat was administered via 60-minute intravenous infusion on days 1 to 5 (schedule A, *n* = 12), or days 1, 3, and 5 (schedules B, *n* = 17, and C, *n* = 19) of 21-day cycles. Schedule B in... περισσότερα »
Imatinib in Metastatic Dermatofibrosarcoma Protuberans
Imatinib in Metastatic Dermatofibrosarcoma Protuberans: *Purpose:* To report on imatinib mesylate (IM) in patients with metastatic dermatofibrosarcoma protuberans (DFSP)/fibrosarcomatous (FS)-DFSP and on the impact of the treatment on tumor biology. *Experimental design:* Ten consecutive patients treated with IM from 2007 to 2015 for a metastatic relapse from DFSP/FS-DFSP were identified. FISH analysis for *COL1A1-PDGFB* was performed. Two IM-treated and 4 naïve FS-DFSP were transcriptionally profiled by RNAseq on HiScanSQ platform. Differential gene expression was analyzed with e...περισσότερα »
Safety of VX15/2503 in Patients with Advanced Solid Tumors
Safety of VX15/2503 in Patients with Advanced Solid Tumors: *Purpose:* Study objectives included evaluating the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of VX15/2503 in advanced solid tumor patients. *Experimental Design:* Weekly i.v. doses were administered on a 28-day cycle. Safety, immunogenicity, PK, efficacy, T-cell membrane–associated SEMA4D (cSEMA4D) expression and saturation, soluble SEMA4D (sSEMA4D) serum levels, and serum biomarker levels were evaluated. *Results:* Forty-two patients were enrolled into seven sequential coh... περισσότερα »
Microsatellite instability (MSI) Frequency in Cancer
MSI Frequency in Cancer: Initial results by Le and colleagues, which were published in the June 25, 2015 issue of the *New England Journal of Medicine*, report significant responses of cancers with microsatellite instability (MSI) to anti–PD-1 inhibitors in patients who failed conventional therapy. This finding fits into a broader body of research associating somatic hypermutation and neoepitope formation with response to immunotherapy, with the added benefit of relying on a simple, widely used diagnostic test. This review surveys the pathogenesis and prognostic value of MSI, diagn... περισσότερα »
Neoantigens and Immunotherapy
Neoantigens and Immunotherapy: Recent advances in immune checkpoint blockade therapy have revolutionized the treatment of cancer. Tumor-specific antigens that are generated by somatic mutation, neoantigens, can influence patient response to immunotherapy and contribute to tumor shrinkage. Recent evidence demonstrating the success of checkpoint blockade immunotherapy in boosting T-cell reactivity against patient-specific neoantigens constitutes a strong rationale for the development of personalized vaccines against these nonself peptides. With the decreasing cost of next-generation ...περισσότερα »
Crizotinib and Chemotherapy Synergize in Neuroblastoma
Crizotinib and Chemotherapy Synergize in Neuroblastoma: *Purpose:* The presence of an *ALK* aberration correlates with inferior survival for patients with high-risk neuroblastoma. The emergence of ALK inhibitors such as crizotinib has provided novel treatment opportunities. However, certain *ALK* mutations result in *de novo* crizotinib resistance, and a phase I trial of crizotinib showed a lack of response in patients harboring those *ALK* mutations. Thus, understanding mechanisms of resistance and defining circumvention strategies for the clinic is critical. *Experimental Design:... περισσότερα »
Targeting Reawakening of Cancer Stem Cells
Targeting Reawakening of Cancer Stem Cells: Cytotoxic chemotherapy remains the first-line therapy for many advanced solid tumors; hence, understanding the underlying mechanisms to overcome chemoresistance remains a top research priority. In the clinic, chemotherapy is administered in multiple cycles that are spaced out to allow the recovery or repopulation of normal tissues and tissue stem cells between treatment cycles. However, residual surviving cancer cells and cancer stem cells can also repopulate tumors during the gap periods between chemotherapy cycles. Tumor repopulation is... περισσότερα »
High-Grade Progression of Neuroendocrine Tumors
High-Grade Progression of Neuroendocrine Tumors: *Purpose:* Most well-differentiated neuroendocrine tumors (WD-NET) of the enteropancreatic system are low-intermediate grade (G1, G2). Elevated proliferation demonstrated by either a brisk mitotic rate (>20/10 high power fields) or high Ki-67 index (>20%) defines a group of aggressive neoplasms designated as high-grade (G3) neuroendocrine carcinoma (NEC). High-grade NEC is equated with poorly differentiated NEC (PD-NEC) and is associated with a dismal outcome. Progression of WD-NETs to a high-grade neuroendocrine neoplasm very rarely...περισσότερα »
Nivolumab in Metastatic Melanoma: irAE Relation to Survival
Nivolumab in Metastatic Melanoma: irAE Relation to Survival: *Purpose:* Retrospective analysis of irAEs in melanoma patients treated with nivolumab. *Experimental Design:* Data were pooled from 148 patients (33 resected, 115 unresectable) treated with nivolumab plus peptide vaccine or nivolumab alone every 2 weeks for 12 weeks. Patients with stable disease or regression received an additional 12-week cycle, then nivolumab alone every 12 weeks for up to 2 additional years. Frequency, grade, and characteristics of immune-related adverse events (irAE) were analyzed. A 12-week landmar...περισσότερα »
Citrate is an inhibitor of crystal growth : a main therapeutical target in stone formers
Pears and renal stones: possible weapon for prevention? A comprehensive narrative review: Urinary stones have been recognized as a human disease since dawn of history and treatment of this condition is reported by Egyptian medical writings. Also, pears have a very long history, being one of the earliest cultivated fruit trees and also known for medicinal use. Urinary tract stone formation represents a common condition and also a significant burden for health care service, due also to possible frequent relapses. Furthermore, urinary stones have been reported to have relationship wit... περισσότερα »
Evaluation of SCUBE-1 and sCD40L biomarkers in patients with hypothyroidism due to Hashimoto’s thyroiditis: a single-blind, controlled clinical study
Evaluation of SCUBE-1 and sCD40L biomarkers in patients with hypothyroidism due to Hashimoto’s thyroiditis: a single-blind, controlled clinical study: *OBJECTIVE:* This study was performed to investigate the levels of platelet activation marker SCUBE-1 and sCD40L which plays some role in the progression of atherosclerosis, in patients with hypothyroidism due to Hashimoto’s thyroiditis. *PATIENTS AND METHODS:* The cohort of this study includes 90 patients and 35 healthy volunteers, who admitted to the internal medicine out-patient. Simultaneously in the same samples; SCUBE-1 and sCD...περισσότερα »
Chronic thyroid hormone treatment and withdrawal in male adults
Desensitization and incomplete recovery of hepatic target genes after chronic thyroid hormone treatment and withdrawal in male adult mice: Endocrinology, Early Release. Kenji Ohba1, Melvin Khee-Shing Leow2, Brijesh Kumar Singh1, Rohit Anthony Sinha1, Ronny Lesmana1,3, Xiao-Hui Liao4, Sujoy Ghosh1, Samuel Refetoff4,5, Judy Chia Ghee Sng6, and Paul Michael Yen1 Address all correspondence and requests for reprints to: Paul M. Yen, Laboratory of Hormonal Regulation, Cardiovascular & Metabolic Disorders Program, Duke-NUS Medical School, 8 College Road, Singapore 169 857, Singapore .... περισσότερα »
Vascular stiffness induced by Western Diet in females
Endothelial estrogen receptor alpha does not protect against vascular stiffness induced by Western Diet in female mice: Endocrinology, Early Release. Camila Manrique, Guido Lastra, Francisco I. Ramirez-Perez, Dominic Haertling, Vincent G. DeMarco, Annayya R. Aroor, Guanghong Jia, Dongqing Chen, Brady J Barron, Mona Garro, Jaume Padilla, Luis A. Martinez-Lemus, and James R. Sowers Address all correspondence and requests for reprints to: Camila Manrique MD, Assistant Professor of Medicine, University of Missouri, D109 Diabetes Center HSC, One Hospital Drive, Columbia, MO 65 21... περισσότερα »
Model of Graves' orbitopathy under different environments
Comparative assessment of female mouse model of Graves' orbitopathy under different environments, accompanied by pro-inflammatory cytokine and T cell responses to thyrotropin hormone receptor antigen: Endocrinology, Early Release. Utta Berchner-Pfannschmidt1,*, Sajad Moshkelgosha1,2,*, Salvador Diaz-Cano3, Bärbel Edelmann4, Gina-Eva Görtz1, Mareike Horstmann1, Alistair Noble2, Wiebke Hansen5, Anja Eckstein1,#, and J Paul Banga1,2,# Address all correspondence and requests for reprints to: #J Paul Banga, PhD; Anja Eckstein, MD, Molecular Ophthalmology, Department of Ophthalmol...περισσότερα »
Electrospun PVP Mats with Propolis and Silver Nanoparticles for Fast Releasing Wound Dressing
Formation and Biopharmaceutical Characterization of Electrospun PVP Mats with Propolis and Silver Nanoparticles for Fast Releasing Wound Dressing: Antibacterial, antiviral, antifungal, antioxidant, anti-inflammatory, and anticancer activities of propolis and its ability to stimulate the immune system and promote wound healing make it a proper component for wound dressing materials. Silver nanoparticles are recognized to demonstrate strong antiseptic and antimicrobial activity; thus, it also could be considered in the development of products for wound healing. Combining propolis and ... περισσότερα »
High Frequency Electromagnetic Fields
Plant Responses to High Frequency Electromagnetic Fields: High frequency nonionizing electromagnetic fields (HF-EMF) that are increasingly present in the environment constitute a genuine environmental stimulus able to evoke specific responses in plants that share many similarities with those observed after a stressful treatment. Plants constitute an outstanding model to study such interactions since their architecture (high surface area to volume ratio) optimizes their interaction with the environment. In the present review, after identifying the main exposure devices (transverse an...περισσότερα »
Code of medical ethics
The static evolution of the new Italian code of medical ethics: Eight years since the last revision, in May 2014 the Italian code of medical ethics has been updated. Here, the Authors examine the reform in the light of the increasing difficulties of the medical profession arising from the severity of the Italian law Courts. The most significant aspects of this new code are firstly, the patient’s freedom of self-determination and secondly, risk prevention through the disclosure of errors and adverse events. However, in both areas the reform seems to be less effective if we compare t... περισσότερα »
Calm Sea's Waves
Calm Seas – A Response to Waves of FOAM: [image: sea-black-and-white-water-wave.jpg?resiz] A response to a post on adding structure to Social Media Med-Ed EMCrit by Scott Weingart.
Crizotinib and Chemotherapy Synergize in Neuroblastoma
Purpose: The presence of an ALK aberration correlates with inferior survival for patients with high-risk neuroblastoma. The emergence of ALK inhibitors such as crizotinib has provided novel treatment opportunities. However, certain ALK mutations result in de novo crizotinib resistance, and a phase I trial of crizotinib showed a lack of response in patients harboring those… Continue reading Crizotinib and Chemotherapy Synergize in Neuroblastoma
Neoantigens and Immunotherapy
Recent advances in immune checkpoint blockade therapy have revolutionized the treatment of cancer. Tumor-specific antigens that are generated by somatic mutation, neoantigens, can influence patient response to immunotherapy and contribute to tumor shrinkage. Recent evidence demonstrating the success of checkpoint blockade immunotherapy in boosting T-cell reactivity against patient-specific neoantigens constitutes a strong rationale for the… Continue reading Neoantigens and Immunotherapy
ESR1 Mutations Detected in Circulating Tumor DNA
Purpose: Mutations in the estrogen receptor (ER)α gene, ESR1, have been identified in breast cancer metastases after progression on endocrine therapies. Because of limitations of metastatic biopsies, the reported frequency of ESR1 mutations may be underestimated. Here, we show a high frequency of ESR1 mutations using circulating plasma tumor DNA (ptDNA) from patients with metastatic… Continue reading ESR1 Mutations Detected in Circulating Tumor DNA
ESR1 Mutations Detected in Circulating Tumor DNA
Purpose: Mutations in the estrogen receptor (ER)α gene, ESR1, have been identified in breast cancer metastases after progression on endocrine therapies. Because of limitations of metastatic biopsies, the reported frequency of ESR1 mutations may be underestimated. Here, we show a high frequency of ESR1 mutations using circulating plasma tumor DNA (ptDNA) from patients with metastatic… Continue reading ESR1 Mutations Detected in Circulating Tumor DNA
MSI Frequency in Cancer
Initial results by Le and colleagues, which were published in the June 25, 2015 issue of the New England Journal of Medicine, report significant responses of cancers with microsatellite instability (MSI) to anti–PD-1 inhibitors in patients who failed conventional therapy. This finding fits into a broader body of research associating somatic hypermutation and neoepitope formation… Continue reading MSI Frequency in Cancer
MSI Frequency in Cancer
Initial results by Le and colleagues, which were published in the June 25, 2015 issue of the New England Journal of Medicine, report significant responses of cancers with microsatellite instability (MSI) to anti–PD-1 inhibitors in patients who failed conventional therapy. This finding fits into a broader body of research associating somatic hypermutation and neoepitope formation… Continue reading MSI Frequency in Cancer
Selected Articles from This Issue
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/213PMgD via IFTTT
FCGR Polymorphisms Not Predictive in Follicular Lymphoma
Purpose: Preclinical studies suggest that SNPs in the Fc gamma receptor (FCGR) genes influence response to rituximab, but the clinical relevance of this is uncertain. Experimental Design: We prospectively obtained specimens for genotyping in the rituximab extended schedule or re-treatment trial (RESORT) study, in which 408 previously untreated, low tumor burden follicular lymphoma (FL) patients… Continue reading FCGR Polymorphisms Not Predictive in Follicular Lymphoma
Selected Articles from This Issue
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/213PMgD via IFTTT
FCGR Polymorphisms Not Predictive in Follicular Lymphoma
Purpose: Preclinical studies suggest that SNPs in the Fc gamma receptor (FCGR) genes influence response to rituximab, but the clinical relevance of this is uncertain. Experimental Design: We prospectively obtained specimens for genotyping in the rituximab extended schedule or re-treatment trial (RESORT) study, in which 408 previously untreated, low tumor burden follicular lymphoma (FL) patients… Continue reading FCGR Polymorphisms Not Predictive in Follicular Lymphoma
Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis predominantly targeting medium-sized arteries
Polyarteritis Nodosa: A contemporary overview via Autoimmunity Reviews Publication date: Available online 13 February 2016 *Source:*Autoimmunity Reviews Author(s): Armando De Virgilio, Antonio Greco, Giuseppe Magliulo, Andrea Gallo, Giovanni Ruoppolo, Michela Conte, Salvatore Martellucci, Marco de Vincentiis Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis predominantly targeting medium-sized arteries. PAN is a rare form of vasculitis, and the precise frequency of this disease is difficult to determine. The major environmental factor associated with PAN is HBV infection...περισσότερα »
Obesity and rhinitis
in a nationwide study of children and adults in the United States via Allergy and Clinical Immunology Publication date: Available online 13 February 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Yueh-Ying Han, Erick Forno, Mudita Gogna, Juan C. Celedón BackgroundObesity has been associated with higher risk of asthma and asthma severity both in children and adults. However, studies evaluating the relation between obesity and rhinitis have yielded conflicting results.MethodsWe performed a cross-sectional study of obesity indicators and rhinitis using data from 8165 ...περισσότερα »
Immunogenicity : T-cell epitope conservation across allergen species
T-cell epitope conservation across allergen species is a major determinant of immunogenicity via Allergy and Clinical Immunology Publication date: Available online 13 February 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Luise Westernberg, Véronique Schulten, Jason A. Greenbaum, Sara Natali, Victoria Tripple, Denise M. McKinney, April Frazier, Heidi Hofer, Michael Wallner, Federica Sallusto, Alessandro Sette, Bjoern Peters BackgroundPatients with pollen allergies are frequently polysensitized. Pollens contain epitopes that are conserved across multiple species.Ob... περισσότερα »
Chemokine release from human rhinovirus
–infected airway epithelial cells promotes fibroblast migration via Allergy and Clinical Immunology Publication date: Available online 13 February 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Christopher Shelfoon, Sami Shariff, Suzanne L. Traves, Cora Kooi, Richard Leigh, David Proud BackgroundThickening of the lamina reticularis, a feature of remodeling in the asthmatic airways, is now known to be present in young children who wheeze. Human rhinovirus (HRV) infection is a common trigger for childhood wheezing, which is a risk factor for subsequent asthma developm... περισσότερα »
Natural killer cell adoptive immunotherapy
: Coming of age via Clinical Immunology Publication date: Available online 14 February 2016 *Source:*Clinical Immunology Author(s): Letícia Baggio, Álvaro Macedo Laureano, Lucia Mariano da Rocha Silla, Dean Anthony Lee Cell therapy is a promising alternative to harsh chemotherapy and radiation therapy for cancer. Natural killer (NK) cells in particular have great potential for direct use in adoptive immunotherapy (AI) for cancer and to improve the graft-vs-leukemia (GVL) effect of hematopoietic stem cell transplants (HSCTs). NK cell number and function are associated with a strong GVL...περισσότερα »
Photodistributed telangiectasia following use of escitalopram
Photodistributed telangiectasia following use of escitalopram via Allergology International Publication date: Available online 14 February 2016 *Source:*Allergology International Author(s): Mario Vaccaro, Gioacchino Calapai, Fabrizio Guarneri, Carmen Mannucci, Maria Lentini, Serafinella P. Cannavò [image: (a) Telangiectasia widely distributed on the face. (b) Forearms and on the dorsa ...] [image: Epidermis was normal. Blood vessels in the superficial dermis were prominent and ...]
FIRST ON 5: Norm Coleman Optimistic He’ll Beat Cancer – KSTP.com
[image: 1Kk88WE] KSTP.com *FIRST ON 5: Norm Coleman Optimistic He’ll Beat Cancer* *KSTP.com* … a “parched” throat for about six weeks that finally prompted him to see his doctor. After noting his *tonsil* seemed inflamed, Coleman was directed to a specialist. Before he made it to that appointment a lump had appeared on his neck. It proved to *…* *and more »* from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1mC5boJ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med ... περισσότερα »
Spit test for cancer takes 10 minutes and has nearly perfect accuracy – International Business Times UK
[image: 1Kk88WN] International Business Times UK *Spit test for cancer takes 10 minutes and has nearly perfect accuracy* *International Business Times UK* The team first discovered *cancer* could be detected from saliva in 2004, when they use it to find oral *cancers*. According to a statement on the Salivary Diagnostic’s website, the team has used saliva to diagnose “*salivary gland* tumours, Sjogren’s *…* *and more »* from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1mC5boX via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Cret... περισσότερα »
Janet Jackson Tumor Scare: Steps Out In Public After Throat Surgery – Health Aim
[image: 1mC5b8t] Health Aim *Janet Jackson Tumor Scare: Steps Out In Public After Throat Surgery* *Health Aim* But what are the symptoms and risk factors of throat *cancer*? A few insights were referenced from mayoclinic.org. Throat *cancer* develops in the pharynx, voice box or *tonsils* as cancerous *tumors* grows in them. Common symptoms are cough, change in voice, … from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Kk86Ou via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 ... περισσότερα »
Stunning find: Women who have sex a lot are less likely to get cancer – Morning Ticker
[image: 1mC590i] Morning Ticker *Stunning find: Women who have sex a lot are less likely to get cancer* *Morning Ticker* The human papillomavirus (HPV) is one of the most common sexually transmitted diseases, yet women who have a higher number of sexual partners are less likely to get *cancer* of the throat and mouth from HPV, according to a Daily Mail report. The findings *…* *and more »* from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Kk88G5 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026...περισσότερα »
Regulation of Nox1 by NoxO1 Ubiquitination
The generation of reactive oxygen species (ROS) is required for proper cell signaling, but must be tightly regulated to minimize deleterious oxidizing effects. Activation of the NADPH oxidases (Nox) triggers ROS production and, thus, regulatory mechanisms exist to properly control Nox activity. In this study, we report a novel mechanism in which Nox1 activity is regulated through the proteasomal degradation of Nox organizer 1 (NoxO1). We found that through the interaction between NoxO1 and growth receptor–bound protein 2 (Grb2), the Casitas B–lineage lymphoma (Cbl) E3 ligase was r...περισσότερα »
Requirement of HMGA2 in TSC
Tuberous sclerosis (TSC) is a tumor suppressor gene syndrome that is associated with the widespread development of mesenchymal tumor types. Genetically, TSC is said to occur through a classical biallelic inactivation of either TSC genes (TSC1, hamartin or TSC2, tuberin), an event that is implicated in the induction of the mTOR pathway and subsequent tumorigenesis. High Mobility Group A2 (HMGA2), an architectural transcription factor, is known to regulate mesenchymal differentiation and drive mesenchymal tumorigenesis in vivo. Here, we investigated the role of HMGA2 in the pathogen...περισσότερα »
Correction: Tumor Angiogenesis Mediated by Myeloid Cells Is Negatively Regulated by CEACAM1
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1KQybEP via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PWfRuq via IFTTT
CD74-NRG1 Fusion Gene Product Confers Cancer Stem Cell Properties
The CD74-Neuregulin1 (NRG1) fusion gene was recently identified as novel driver of invasive mucinous adenocarcinoma, a malignant form of lung cancer. However, the function of the CD74-NRG1 fusion gene in adenocarcinoma pathogenesis and the mechanisms by which it may impart protumorigenic characteristics to cancer stem cells (CSC) is still unclear. In this study, we found that the expression of the CD74-NRG1 fusion gene increased the population of lung cancer cells with CSC-like properties. CD74-NRG1 expression facilitated sphere formation not only of cancer cells, but also of nonm...περισσότερα »
Role of WASF3-CYFIP Interaction in Invasion
Activation of the WASF3 protein by extracellular stimuli promotes actin cytoskeleton reorganization and facilitates cancer cell invasion, whereas WASF3 depletion suppresses invasion and metastasis. In quiescent cells, the interaction between WASF3 and a complex of proteins, including CYFIP1, acts as a conformational restraint to prevent WASF3 activation. Therefore, we took advantage of this endogenous regulatory mechanism to investigate potential sites that disrupt WASF3 function. Here, we show that genetic knockdown of CYFIP1 in cancer cells led to the destabilization of the WASF3...περισσότερα »
SSBP1 Suppresses Triple-Negative Breast Cancer Metastasis
Triple-negative breast cancer (TNBC) is a highly aggressive tumor subtype lacking effective prognostic indicators or therapeutic targets. Mitochondrial function is dysregulated frequently in cancer cells to allow for adaptation to a harsh tumor microenvironment. Targeting mitochondrial biogenesis and bioenergetics is, therefore, an attractive therapeutic strategy. In this study, we performed quantitative proteomic analyses in human parental and metastatic breast cancer cell lines to identify mitochondrial proteins involved in TNBC metastasis. We found that single-strand DNA-bindin... περισσότερα »
Injury-Driven Dermal Stiffness Drives cSCC
Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic skin fragility disorder characterized by injury-driven blister formation, progressive soft-tissue fibrosis, and a highly elevated risk of early-onset aggressive cutaneous squamous cell carcinoma (cSCC). However, the mechanisms underlying the unusually rapid progression of RDEB to cSCC are unknown. In this study, we investigated the contribution of injury-induced skin alterations to cSCC development by using a genetic model of RDEB and organotypic skin cultures. Analysis of RDEB patient samples suggested that premaligna... περισσότερα »
In Vivo Suppression of Breast Cancer Metastasis to Brain by Penfluridol
Metastasis of breast cancer, especially to the brain, is the major cause of mortality. The inability of anticancer agents to cross the blood-brain-barrier represents a critical challenge for successful treatment. In the current study, we investigated the antimetastatic potential of penfluridol, an antipsychotic drug frequently prescribed for schizophrenia with anticancer activity. We show that penfluridol induced apoptosis and reduced the survival of several metastatic triple-negative breast cancer (TNBC) cell lines. In addition, penfluridol treatment significantly reduced the exp... περισσότερα »
Cabazitaxel Reverses EMT in Prostate Cancer
Patients with metastatic castration-resistant prostate cancer (CRPC) frequently develop therapeutic resistance to taxane chemotherapy and antiandrogens. Cabazitaxel is a second-line taxane chemotherapeutic agent that provides additional survival benefits to patients with advanced disease. In this study, we sought to identify the mechanism of action of combined cabazitaxel and androgen receptor (AR) targeting in preclinical models of advanced prostate cancer. We found that cabazitaxel induced mitotic spindle collapse and multinucleation by targeting the microtubule depolymerizing k...περισσότερα »
Hypoxia-Induced EMT Creates Immunosuppression
Portal vein tumor thrombosis (PVTT) is a significant risk factor for metastasis in hepatocellular carcinoma (HCC) patients and is therefore associated with poor prognosis. The presence of PVTT frequently accompanies substantial hypoxia within the tumor microenvironment, which is suggested to accelerate tumor metastasis, but it is unclear how this occurs. Recent evidence has shown that the hypoxia-inducible factor HIF-1α induces epithelial-to-mesenchymal transition (EMT) in tumor cells to facilitate metastasis. In this study, we investigated whether hypoxia-induced EMT in cancer ce... περισσότερα »
Ranking Anticancer Drugs
Whole chromosomal instability (CIN), manifested as unequal chromosome distribution during cell division, is a distinguishing feature of most cancer types. CIN is generally considered to drive tumorigenesis, but a threshold level exists whereby further increases in CIN frequency in fact hinder tumor growth. While this attribute is appealing for therapeutic exploitation, drugs that increase CIN beyond this therapeutic threshold are currently limited. In our previous work, we developed a quantitative assay for measuring CIN based on the use of a nonessential human artificial chromoso... περισσότερα »
JARID1D Has an Anti-Invasive Function
Entire or partial deletions of the male-specific Y chromosome are associated with tumorigenesis, but whether any male-specific genes located on this chromosome play a tumor-suppressive role is unknown. Here, we report that the histone H3 lysine 4 (H3K4) demethylase JARID1D (also called KDM5D and SMCY), a male-specific protein, represses gene expression programs associated with cell invasiveness and suppresses the invasion of prostate cancer cells in vitro and in vivo. We found that JARID1D specifically repressed the invasion-associated genes MMP1, MMP2, MMP3, MMP7, and Slug by dem... περισσότερα »
IL6 Trans-signaling Promotes Kras Lung Cancer
Oncogenic KRAS mutations occur frequently in lung adenocarcinoma. The signaling pathways activated by IL6 promote Kras-driven lung tumorigenesis, but the basis for this cooperation is uncertain. In this study, we used the gp130F/F (Il6st) knock-in mouse model to examine the pathogenic contribution of hyperactivation of the STAT3 arm of IL6 signaling on KRAS-driven lung tumorigenesis. Malignant growths in the gp130F/F:KrasG12D model displayed features of atypical adenomatous hyperplasia, adenocarcinoma in situ, and invasive adenocarcinoma throughout the lung, as compared with paren... περισσότερα »
miR-34a Shows Tumor Suppressor Functions in TNBC
Triple-negative breast cancer (TNBC) is an aggressive subtype with no clinically proven biologically targeted treatment options. The molecular heterogeneity of TNBC and lack of high frequency driver mutations other than TP53 have hindered the development of new and effective therapies that significantly improve patient outcomes. miRNAs, global regulators of survival and proliferation pathways important in tumor development and maintenance, are becoming promising therapeutic agents. We performed miRNA-profiling studies in different TNBC subtypes to identify miRNAs that significantl... περισσότερα »
Wnt Inhibitor LF3
Wnt/β-catenin signaling is a highly conserved pathway essential for embryogenesis and tissue homeostasis. However, deregulation of this pathway can initiate and promote human malignancies, especially of the colon and head and neck. Therefore, Wnt/β-catenin signaling represents an attractive target for cancer therapy. We performed high-throughput screening using AlphaScreen and ELISA techniques to identify small molecules that disrupt the critical interaction between β-catenin and the transcription factor TCF4 required for signal transduction. We found that compound LF3, a 4-thiour...περισσότερα »
Role of Macrophages in Wound-Induced Skin Cancer
Macrophages are essential for the progression and maintenance of many cancers, but their role during the earliest stages of tumor formation is unclear. To test this, we used a previously described transgenic mouse model of wound-induced skin tumorigenesis, in which expression of constitutively active MEK1 in differentiating epidermal cells results in chronic inflammation (InvEE mice). Upon wounding, the number of epidermal and dermal monocytes and macrophages increased in wild-type and InvEE skin, but the increase was greater, more rapid, and more sustained in InvEE skin. Macropha...περισσότερα »
ESR1 Mutations Detected in Circulating Tumor DNA
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
Purpose: Mutations in the estrogen receptor (ER)α gene, ESR1, have been identified in breast cancer metastases after progression on endocrine therapies. Because of limitations of metastatic biopsies, the reported frequency of ESR1 mutations may be underestimated. Here, we show a high frequency of ESR1 mutations using circulating plasma tumor DNA (ptDNA) from patients with metastatic […]
Cognitive autonomy among adolescents with and without hearing loss
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
Cognitive autonomy among adolescents with and without hearing loss: Associations with perceived social support.: J Adolesc. 2016 Feb;48:36-44 Authors: Michael R, Attias J Abstract Cognitive autonomy is a skill which may help adolescents prepare for important decisions in adulthood. The current study examined the associations between cognitive autonomy and perceived social support among adolescents with […]
MSI Frequency in Cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
Initial results by Le and colleagues, which were published in the June 25, 2015 issue of the New England Journal of Medicine, report significant responses of cancers with microsatellite instability (MSI) to anti–PD-1 inhibitors in patients who failed conventional therapy. This finding fits into a broader body of research associating somatic hypermutation and neoepitope formation […]
Raised arterial blood pressure in neurokinin-1 receptor deficient mice (NK1R-/-): Evidence for a neural rather than a vascular mechanism
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
Abstract Mice with functional ablation of the neurokinin-1 receptor gene (NK1R-/-) express behavioural abnormalities equivalent to those seen in Attention Deficit Hyperactivity Disorder (ADHD). An established model of ADHD is the spontaneously hypertensive rat (SHR), which exhibits high blood pressure due to increased central sympathetic drive. In light of the evidence that NK1R also influence […]
Functional near-infrared spectroscopy for neuroimaging in cochlear implant recipients
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
Functional near-infrared spectroscopy for neuroimaging in cochlear implant recipients via Hearing Research Publication date: Available online 13 February 2016 Source:Hearing Research Author(s): Joe Saliba, Heather Bortfeld, Daniel J. Levitin, John S. Oghalai Functional neuroimaging can provide insight into the neurobiological factors that contribute to the variations in individual hearing outcomes following cochlear implantation. To date, […]
Selected Articles from This Issue
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
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FCGR Polymorphisms Not Predictive in Follicular Lymphoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
Purpose: Preclinical studies suggest that SNPs in the Fc gamma receptor (FCGR) genes influence response to rituximab, but the clinical relevance of this is uncertain. Experimental Design: We prospectively obtained specimens for genotyping in the rituximab extended schedule or re-treatment trial (RESORT) study, in which 408 previously untreated, low tumor burden follicular lymphoma (FL) patients […]
FIRST ON 5: Norm Coleman Optimistic He’ll Beat Cancer – KSTP.com
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
KSTP.com FIRST ON 5: Norm Coleman Optimistic He’ll Beat Cancer KSTP.com … a “parched” throat for about six weeks that finally prompted him to see his doctor. After noting his tonsil seemed inflamed, Coleman was directed to a specialist. Before he made it to that appointment a lump had appeared on his neck. It proved […]
Survival of TNBC Patients in the HIBCRIT-1 Study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
Purpose: To compare phenotype features and survival of triple-negative breast cancers (TNBC) versus non-TNBCs detected during a multimodal annual screening of high-risk women. Experimental Design: Analysis of data from asymptomatic high-risk women diagnosed with invasive breast cancer during the HIBCRIT-1 study with median 9.7-year follow-up. Results: Of 501 enrolled women with BRCA1/2 mutation or strong […]
Spit test for cancer takes 10 minutes and has nearly perfect accuracy – International Business Times UK
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
International Business Times UK Spit test for cancer takes 10 minutes and has nearly perfect accuracy International Business Times UK The team first discovered cancer could be detected from saliva in 2004, when they use it to find oral cancers. According to a statement on the Salivary Diagnostic’s website, the team has used saliva to […]
Dry mouth : Enhanced salivary secretion by interferential current stimulation
: a pilot study via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 13 February 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Yoko Hasegawa, Kazuma Sugahara, Saori Sano, Ayumi Sakuramoto, Hiromitsu Kishimoto, Yoshitaka Oku ObjectiveThis pilot study tested the effects of submandibular / sublingual gland stimulation by interferential current stimulation (IFCS), a non-invasive mode of electrical stimulation.Study DesignThree groups were enrolled in this study: 20 young, 19 elderly and 21 dry mouth ...περισσότερα »
Stable fixation with absorbable sutures in craniofacial surgery
Stable fixation with absorbable sutures in craniofacial surgery via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 13 February 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): C. Linz, F. Kunz, J. Krauß, H. Böhm, C. Wirth, S. Hartmann, J. Wirbelauer, T. Schweitzer The present study analyses the exclusive use of absorbable suture material (Vicryl®, Ethicon, Germany) in the fixation of transposed bone segments in craniofacial surgery without modification of the osteotomy design.Among 129 children up to 24 months of age...περισσότερα »
Multi-slice computed tomography (MSCT) and cone beam computed tomography (CBCT)
The impact of different cone beam computed tomography and multi-slice computed tomography scan parameters on virtual three-dimensional model accuracy using a highly precise ex vivo evaluation method via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 13 February 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Ragai-Edward Matta, Cornelius von Wilmowsky, Winfried Neuhuber, Michael Lell, Friedrich W. Neukam, Werner Adler, Manfred Wichmann, Bastian Bergauer ObjectivesMulti-slice computed tomography (MSCT) and cone beam ... περισσότερα »
Cell phone use is associated with an inflammatory cytokine profile of parotid gland saliva
Cell phone use is associated with an inflammatory cytokine profile of parotid gland saliva: Background There is controversy on the effects of the non-ionizing radiation emitted by cell phones on cellular processes and the impact of such radiation exposure on health. The purpose of this study was to investigate whether cell phone use alters cytokine expression in the saliva produced by the parotid glands. Methods Cytokine expression profile was determined by enzyme linked immuno sorbent assay (ELISA) in the saliva produced by the parotid glands in healthy volunteers, and correlated ... περισσότερα »
Assessment of salivary total antioxidant capacity in patients with primary untreated head and neck squamous cell carcinoma with ORAC
Assessment of salivary total antioxidant capacity in patients with primary untreated head and neck squamous cell carcinoma with ORAC: Background Oxidative DNA damage leads to abnormalities in endogenous cellular processes and constitutes a direct link between free radicals, antioxidants and squamous cell carcinoma (SCC). Oxygen radical absorbance capacity (ORAC) method is used to measure antioxidant capacity versus oxygen free radicals. There is no report on the application of ORAC to evaluate salivary antioxidant capacity in patients with head and neck SCC. This study investigated... περισσότερα »
Basic Tastes and Pitch
"Turn Up the Taste": Assessing the Role of Taste Intensity and Emotion in Mediating Crossmodal Correspondences between Basic Tastes and Pitch Chem Senses. 2016 Feb 12; Authors: Wang QJ, Wang S, Spence C Abstract People intuitively match basic tastes to sounds of different pitches, and the matches that they make tend to be consistent across individuals. It is, though, not altogether clear what governs such crossmodal mappings between taste and auditory pitch. Here, we assess whether variations in taste intensity influence the matching of taste to pitch as well as the role of emotio...περισσότερα »
Statins to Augment Progenitor Cell Function in Preclinical and Clinical Studies of Regenerative Therapy
Use of Statins to Augment Progenitor Cell Function in Preclinical and Clinical Studies of Regenerative Therapy: a Systematic Review Stem Cell Rev. 2016 Feb 12; Authors: Park A, Barrera-Ramirez J, Ranasinghe I, Pilon S, Sy R, Fergusson D, Allan DS Abstract BACKGROUND: Mesenchymal stromal cells (MSCs) and endothelial progenitor cells (EPCs) are used in cell-based regenerative therapy. HMG CoA reductase inhibitors (statins) appear promising in blocking apoptosis, prolonging progenitor cell survival and improving their capacity to repair organ function. METHODS: We performed a system... περισσότερα »
Fibrous dysplasia is an uncommon benign tumour in the nasal cavity
Polyostotic fibrous dysplasia of the mandible and bony nasal septum with intracranial expansion via ScienceDirect Publication: Egyptian Journal of Ear, Nose, Throat and Allied Sciences Publication date: March 2016 *Source:*Egyptian Journal of Ear, Nose, Throat and Allied Sciences, Volume 17, Issue 1 Author(s): Jura Numminen, Markus Rautiainen Fibrous dysplasia is an uncommon benign tumour in the nasal cavity. Due to adjacent vital soft tissue structures surgery is often the treatment of choice. We report a rare case of polyostotic fibrous dysplasia of the mandible and the ethmoid bone...περισσότερα »
Missed hypopharyngeal foreign body
: A case report via ScienceDirect Publication: Egyptian Journal of Ear, Nose, Throat and Allied Sciences Publication date: March 2016 *Source:*Egyptian Journal of Ear, Nose, Throat and Allied Sciences, Volume 17, Issue 1 Author(s): Jeyasakthy Saniasiaya, Irfan Mohamad Foreign body ingestion has been a dilemma to many physicians including Otolaryngologist. Naturally, patient turns up at the out-patient department first prior to being referred to the otolaryngologist, which may lead to possibility of missed or neglected foreign body. We report a case of a missed foreign body which turne... περισσότερα »
Massive,painless cervical lymphadenopathy : Rosai Dorfman disease involving paranasal sinuses
Rare case of Rosai Dorfman disease involving paranasal sinuses in paediatric patient: A case report via ScienceDirect Publication: Egyptian Journal of Ear, Nose, Throat and Allied Sciences Publication date: March 2016 *Source:*Egyptian Journal of Ear, Nose, Throat and Allied Sciences, Volume 17, Issue 1 Author(s): Gaurav Ashish, Ramanathan Chandrashekharan, Harshad Parmar Rosai Dorfman disease (RDD) is a rare, benign disease of unknown aetiology. It typically presents with massive, painless cervical lymphadenopathy but may have a varied presentation. We report a paediatric case of RDD ... περισσότερα »
Neck metastasis of a juvenile granulosa cell tumour
. A case report and literature review via ScienceDirect Publication: Egyptian Journal of Ear, Nose, Throat and Allied Sciences Publication date: March 2016 *Source:*Egyptian Journal of Ear, Nose, Throat and Allied Sciences, Volume 17, Issue 1 Author(s): M. Al Khalil, J. Joshi Otero, I. Mujeeb, M. Riyas Juvenile granulosa cell tumour (JGCT) is a rare tumour arising from the ovarian sex cord stroma (SCST) and comprising about 5 percent of all granulosa cell tumours. To our knowledge, a cervical metastasis has not been described before.We report a case of a 19-year-old female who had a l...περισσότερα »
Frontocele
: Experience from a resource challenged environment via ScienceDirect Publication: Egyptian Journal of Ear, Nose, Throat and Allied Sciences Publication date: March 2016 *Source:*Egyptian Journal of Ear, Nose, Throat and Allied Sciences, Volume 17, Issue 1 Author(s): Rowland Agbara, Athanasius Chukwudi Obiadazie, Osamudiamen Joseph Ogbeifun, Uche Albert Okeke Background: Frontocele commonly occurs as a result of obstruction in the outflow tract of the frontal sinus and this may be due to both congenital and acquired factors. Management involves the use of open, endoscopic or combined ... περισσότερα »
Exogenous foreign body (FB) in the tracheobronchial tree : A tooth
From tooth extraction to fatal airway complication in a child – A case report via ScienceDirect Publication: Egyptian Journal of Ear, Nose, Throat and Allied Sciences Publication date: March 2016 *Source:*Egyptian Journal of Ear, Nose, Throat and Allied Sciences, Volume 17, Issue 1 Author(s): Santosh K. Swain, Sangeeta Sahoo, Mahesh C. Sahu Exogenous foreign body (FB) in the tracheobronchial tree is not uncommon especially in infants and children often present with respiratory obstruction that can lead to death if not removed in time. Despite public awareness and education, prevention...περισσότερα »
Head injury with bilateral facial palsy without temporal bone fractures and brain injury
Head injury with sudden onset bilateral facial palsy – Can happen without temporal bone fractures and brain injury! via ScienceDirect Publication: Egyptian Journal of Ear, Nose, Throat and Allied Sciences Publication date: March 2016 *Source:*Egyptian Journal of Ear, Nose, Throat and Allied Sciences, Volume 17, Issue 1 Author(s): Santosh Kumar Swain, Ishwar Chandra Behera, Mahesh Chandra Sahu Bilateral sudden facial nerve palsy is an extremely rare clinical entity and in most instances is idiopathic. Post traumatic sudden onset bilateral facial palsy is even rarer and unique which make...περισσότερα »
Vestibular migraine (VM)
Clinical features of vestibular migraine in Egypt via ScienceDirect Publication: Egyptian Journal of Ear, Nose, Throat and Allied Sciences Publication date: March 2016 *Source:*Egyptian Journal of Ear, Nose, Throat and Allied Sciences, Volume 17, Issue 1 Author(s): Nagwa Hazzaa, Salwa S. El Mowafy BackgroundMany reports have documented a relationship between vestibular and migraine disorders. The term vestibular migraine appeared in an appendix of the third edition of IHS as a first step for new entities (Neuhauser et al., 2001).ObjectiveTo determine the prevalence of vestibular migra...περισσότερα »
Foreign bodies : Surgically repaired esophagus
: An anchor pad for foreign bodies via ScienceDirect Publication: Egyptian Journal of Ear, Nose, Throat and Allied Sciences Publication date: March 2016 *Source:*Egyptian Journal of Ear, Nose, Throat and Allied Sciences, Volume 17, Issue 1 Author(s): Arijit Jotdar, Mainak Dutta, Sohag Kundu, Bhaskar Ghosh, Indranil Chatterjee Children with congenital tracheo-esophageal fistula and esophageal atresia need surgical intervention for their survival. Apart from the several gastro-intestinal and respiratory problems that often follow surgery, there is an increased risk of impaction of forei... περισσότερα »
Acquired cholesteatoma in children
: Clinical features and surgical results via ScienceDirect Publication: Egyptian Journal of Ear, Nose, Throat and Allied Sciences Publication date: March 2016 *Source:*Egyptian Journal of Ear, Nose, Throat and Allied Sciences, Volume 17, Issue 1 Author(s): Olfa Ben Gamra, Wafa Abid, Ines Nacef, Nadia Romdhane, Ines Hariga, Chiraz Mbarek Acquired cholesteatoma in children is an aggressive disease due to its rapid growth and high recurrence rate.ObjectiveTo assess clinical features of cholesteatoma in children and evaluate our experience in the surgical management of this disease.Method... περισσότερα »
High throughput approaches for controlled stem cell differentiation
High throughput approaches for controlled stem cell differentiation via Acta Biomaterialia Publication date: Available online 13 February 2016 *Source:*Acta Biomaterialia Author(s): Hwan D. Kim, Eunjee A. Lee, Young Hwan Choi, Young Hyeon An, Rachel H. Koh, Seunghyun L. Kim, Nathaniel S. Hwang Stem cells have unique ability to undergo self-renewal indefinitely in culture and potential to differentiate into almost all cell types in the human body. However, the developing a method for efficiently differentiating or manipulating these stem cells for therapeutic purposes remains a challeng... περισσότερα »
Cognitive autonomy among adolescents with and without hearing loss
Cognitive autonomy among adolescents with and without hearing loss: Associations with perceived social support.: J Adolesc. 2016 Feb;48:36-44 Authors: Michael R, Attias J Abstract Cognitive autonomy is a skill which may help adolescents prepare for important decisions in adulthood. The current study examined the associations between cognitive autonomy and perceived social support among adolescents with and without hearing loss. Participants were 177 students: 55 were deaf and hard of hearing (dhh) and 122 were hearing. They completed the Cognitive Autonomy and Self-Evaluation Inve... περισσότερα »
Raised arterial blood pressure in neurokinin-1 receptor deficient mice (NK1R-/-): Evidence for a neural rather than a vascular mechanism
Abstract Mice with functional ablation of the neurokinin-1 receptor gene (NK1R-/-) express behavioural abnormalities equivalent to those seen in Attention Deficit Hyperactivity Disorder (ADHD). An established model of ADHD is the spontaneously hypertensive rat (SHR), which exhibits high blood pressure due to increased central sympathetic drive. In light of the evidence that NK1R also influence cardiovascular haemodynamics, we have investigated whether NK1R-/- similarly exhibit raised blood pressure. Cardiovascular parameters were recorded for 24 h in conscious mice using radiotele... περισσότερα »
Functional near-infrared spectroscopy for neuroimaging in cochlear implant recipients
Functional near-infrared spectroscopy for neuroimaging in cochlear implant recipients via Hearing Research [image: S03785955.gif] Publication date: Available online 13 February 2016 *Source:*Hearing Research Author(s): Joe Saliba, Heather Bortfeld, Daniel J. Levitin, John S. Oghalai Functional neuroimaging can provide insight into the neurobiological factors that contribute to the variations in individual hearing outcomes following cochlear implantation. To date, measuring neural activity within the auditory cortex of cochlear implant (CI) recipients has been challenging, primarily b... περισσότερα »
Erratum
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Editorial: PPI-responsive oesophageal eosinophilia and long-term PPI treatment
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Corrigendum
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Letter: ileal bile acid transporter inhibition– is there a potential for drug–drug interaction? Authors’ reply
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Letter: self-pay behaviour patients with chronic hepatitis C who required direct acting anti-viral urgently in a real-world setting
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Journal of Neurology, Vol. 263, Issue 2 - New Issue Alert
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 41 δευτερόλεπτα
If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 02/15/2016 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *Journal of Neurology*. Volume 263 Number 2 is now available online. In this issue Review The full spectrum of ethical issues in the care of patients with ALS: a systematic qualitative review F. Seitzer, H. Kahrass, G. Neitzke & D. Strech » Abstract » Full text HTML » Full text PDF Review Vestibular-evoked myogenic potentials in central vestibular ... περισσότερα »
Spit test for cancer takes 10 minutes and has nearly perfect accuracy – International Business Times UK
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 42 δευτερόλεπτα
International Business Times UK Spit test for cancer takes 10 minutes and has nearly perfect accuracy International Business Times UK The team first discovered cancer could be detected from saliva in 2004, when they use it to find oral cancers. According to a statement on the Salivary Diagnostic’s website, the team has used saliva to […]
FIRST ON 5: Norm Coleman Optimistic He’ll Beat Cancer – KSTP.com
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 42 δευτερόλεπτα
KSTP.com FIRST ON 5: Norm Coleman Optimistic He’ll Beat Cancer KSTP.com … a “parched” throat for about six weeks that finally prompted him to see his doctor. After noting his tonsil seemed inflamed, Coleman was directed to a specialist. Before he made it to that appointment a lump had appeared on his neck. It proved […]
Janet Jackson Tumor Scare: Steps Out In Public After Throat Surgery – Health Aim
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 42 δευτερόλεπτα
Health Aim Janet Jackson Tumor Scare: Steps Out In Public After Throat Surgery Health Aim But what are the symptoms and risk factors of throat cancer? A few insights were referenced from mayoclinic.org. Throat cancer develops in the pharynx, voice box or tonsils as cancerous tumors grows in them. Common symptoms are cough, change in […]
Stunning find: Women who have sex a lot are less likely to get cancer – Morning Ticker
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 42 δευτερόλεπτα
Morning Ticker Stunning find: Women who have sex a lot are less likely to get cancer Morning Ticker The human papillomavirus (HPV) is one of the most common sexually transmitted diseases, yet women who have a higher number of sexual partners are less likely to get cancer of the throat and mouth from HPV, according […]
Regulation of Nox1 by NoxO1 Ubiquitination
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 42 δευτερόλεπτα
The generation of reactive oxygen species (ROS) is required for proper cell signaling, but must be tightly regulated to minimize deleterious oxidizing effects. Activation of the NADPH oxidases (Nox) triggers ROS production and, thus, regulatory mechanisms exist to properly control Nox activity. In this study, we report a novel mechanism in which Nox1 activity is […]
Requirement of HMGA2 in TSC
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 42 δευτερόλεπτα
Tuberous sclerosis (TSC) is a tumor suppressor gene syndrome that is associated with the widespread development of mesenchymal tumor types. Genetically, TSC is said to occur through a classical biallelic inactivation of either TSC genes (TSC1, hamartin or TSC2, tuberin), an event that is implicated in the induction of the mTOR pathway and subsequent tumorigenesis. […]
Correction: Tumor Angiogenesis Mediated by Myeloid Cells Is Negatively Regulated by CEACAM1
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 42 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1KQybEP via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
CD74-NRG1 Fusion Gene Product Confers Cancer Stem Cell Properties
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 42 δευτερόλεπτα
The CD74-Neuregulin1 (NRG1) fusion gene was recently identified as novel driver of invasive mucinous adenocarcinoma, a malignant form of lung cancer. However, the function of the CD74-NRG1 fusion gene in adenocarcinoma pathogenesis and the mechanisms by which it may impart protumorigenic characteristics to cancer stem cells (CSC) is still unclear. In this study, we found […]
Role of WASF3-CYFIP Interaction in Invasion
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 42 δευτερόλεπτα
Activation of the WASF3 protein by extracellular stimuli promotes actin cytoskeleton reorganization and facilitates cancer cell invasion, whereas WASF3 depletion suppresses invasion and metastasis. In quiescent cells, the interaction between WASF3 and a complex of proteins, including CYFIP1, acts as a conformational restraint to prevent WASF3 activation. Therefore, we took advantage of this endogenous regulatory […]
SSBP1 Suppresses Triple-Negative Breast Cancer Metastasis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 42 δευτερόλεπτα
Triple-negative breast cancer (TNBC) is a highly aggressive tumor subtype lacking effective prognostic indicators or therapeutic targets. Mitochondrial function is dysregulated frequently in cancer cells to allow for adaptation to a harsh tumor microenvironment. Targeting mitochondrial biogenesis and bioenergetics is, therefore, an attractive therapeutic strategy. In this study, we performed quantitative proteomic analyses in human […]
Injury-Driven Dermal Stiffness Drives cSCC
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic skin fragility disorder characterized by injury-driven blister formation, progressive soft-tissue fibrosis, and a highly elevated risk of early-onset aggressive cutaneous squamous cell carcinoma (cSCC). However, the mechanisms underlying the unusually rapid progression of RDEB to cSCC are unknown. In this study, we investigated the contribution of injury-induced skin alterations to cSCC development by using a genetic model of RDEB and organotypic skin cultures. Analysis of RDEB patient samples suggested that premaligna... περισσότερα »
Context-dependent use of muscle spindles for human position sense
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Assessment of salivary total antioxidant capacity in patients with primary untreated head and neck squamous cell carcinoma with ORAC
Background Oxidative DNA damage leads to abnormalities in endogenous cellular processes and constitutes a direct link between free radicals, antioxidants and squamous cell carcinoma (SCC). Oxygen radical absorbance capacity (ORAC) method is used to measure antioxidant capacity versus oxygen free radicals. There is no report on the application of ORAC to evaluate salivary antioxidant capacity in patients with head and neck SCC. This study investigated the relation between total antioxidant capacity of saliva, measured with ORAC method, and the incidence, location, size and histopa...περισσότερα »
Cell phone use is associated with an inflammatory cytokine profile of parotid gland saliva
Background There is controversy on the effects of the non-ionizing radiation emitted by cell phones on cellular processes and the impact of such radiation exposure on health. The purpose of this study was to investigate whether cell phone use alters cytokine expression in the saliva produced by the parotid glands. Methods Cytokine expression profile was determined by enzyme linked immuno sorbent assay (ELISA) in the saliva produced by the parotid glands in healthy volunteers, and correlated with self-reported cell phone use and laterality. Results The following parameters were ...περισσότερα »
Associations of Inter- and Intraday Temperature Change With Mortality
In this study we evaluated the association between temperature variation and mortality and compared it with the contribution due to mean daily temperature in 6 cities with different climates. Quasi-Poisson time series regression models were applied to estimate the associations (relative risk and 95% confidence interval) of mean daily temperature (99th and 1st percentiles, with temperature of minimum mortality as the reference category), interday temperature variation (difference between the mean temperatures of 2 neighboring days) and intraday temperature variation (diurnal temper... περισσότερα »
Body Size, Metabolic Factors, and Risk of Endometrial Cancer in Black Women
Total and abdominal obesity, as well as metabolic factors such as type 2 diabetes, have been associated with a higher risk of endometrial cancer in white women. It remains unclear to what extent these factors influence the risk of endometrial cancer in black women. We followed 47,557 participants from the Black Women's Health Study for incident endometrial cancer from 1995 through 2013 (*n* = 274). We used Cox regression models to estimate incidence rate ratios and 95% confidence intervals while accounting for potential confounders. Incidence rate ratios for body mass indices (weig...περισσότερα »
Jump, Hop, or Skip: Modeling Practice Effects in Studies of Determinants of Cognitive Change in Older Adults
Improvements in cognitive test scores upon repeated assessment due to practice effects (PEs) are well documented, but there is no empirical evidence on whether alternative specifications of PEs result in different estimated associations between exposure and rate of cognitive change. If alternative PE specifications produce different estimates of association between an exposure and rate of cognitive change, this would be a challenge for nearly all longitudinal research on determinants of cognitive aging. Using data from 3 cohort studies—the Three-City Study–Dijon (Dijon, France, 19... περισσότερα »
Depressive Symptoms During Adolescence and Young Adulthood and the Development of Type 2 Diabetes Mellitus
Although depression symptoms have been associated with type 2 diabetes mellitus (T2DM) among adults, little is known about the association of adolescent-onset depression and development of T2DM in young adulthood and whether the association differs by sex. We examined the association between high levels of depressive symptoms in adolescence and T2DM in adulthood in the National Longitudinal Study of Adolescent to Adult Health (*n* = 12,657). Adolescents completed the 20-item version of Center for Epidemiologic Studies Depression Scale during wave 1 (mean age, 16 years) and the 10-...περισσότερα »
A Comprehensive Multistate Model Analyzing Associations of Various Risk Factors With the Course of Breast Cancer in a Population-Based Cohort of Breast Cancer Cases
We employed a semi-Markov multistate model for the simultaneous analysis of various endpoints describing the course of breast cancer. Results were compared with those from standard analyses using a Cox proportional hazards model. We included 3,012 patients with invasive breast cancer newly diagnosed between 2001 and 2005 who were recruited in Germany for a population-based study, the Mamma Carcinoma Risk Factor Investigation (MARIE Study), and prospectively followed up until the end of 2009. Locoregional recurrence and distant metastasis were included as intermediate states, and d...περισσότερα »
Efficacy of Schwann Cell (SC) transplantation for spinal cord repair is improved with combinatorial strategies
Abstract When cells (including Schwann cells, SCs) of the PNS could be purified and expanded in number in tissue culture, Richard Bunge in 1975 envisioned that the SCs could be introduced to repair the CNS, as SCs enable axons to regenerate after PNS injury. Importantly, autologous human SCs could be transplanted into injured human spinal cord. Availability of the new culture systems to study interactions between sensory neurons, SCs and fibroblasts increased our knowledge of SC biology in the 70 s and 80 s. Joining the Miami Project to Cure Paralysis in 1989 brought the opportuni... περισσότερα »
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Acid-sensing ion channel 1a induces AMPA receptor plasticity: a link between acidotoxicity and excitotoxicity in hippocampal CA1 neurons
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Context-dependent use of muscle spindles for human position sense
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Letter: aberrant GSTP1 promoter methylation in acute-on-chronic hepatitis B liver failure – authors’ reply
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Letter: ileal bile acid transporter inhibition – is there a potential for drug–drug interaction?
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Letter: long-term use of proton pump inhibitors and risk of neuroendocrine tumours
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Letter: aberrant GSTP1 promoter methylation in acute-on-chronic hepatitis B liver failure
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Editorial: PPI-responsive oesophageal eosinophilia and long-term PPI treatment – authors' reply
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Efficacy of Schwann Cell (SC) transplantation for spinal cord repair is improved with combinatorial strategies
Abstract When cells (including Schwann cells, SCs) of the PNS could be purified and expanded in number in tissue culture, Richard Bunge in 1975 envisioned that the SCs could be introduced to repair the CNS, as SCs enable axons to regenerate after PNS injury. Importantly, autologous human SCs could be transplanted into injured human spinal cord. Availability of the new culture systems to study interactions between sensory neurons, SCs and fibroblasts increased our knowledge of SC biology in the 70 s and 80 s. Joining the Miami Project to Cure Paralysis in 1989 brought the opportuni... περισσότερα »
Issue Information
from #Medicine via ola Kala on Inoreader http://ift.tt/1ohRvRJ Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Assessment of salivary total antioxidant capacity in patients with primary untreated head and neck squamous cell carcinoma with ORAC
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Background Oxidative DNA damage leads to abnormalities in endogenous cellular processes and constitutes a direct link between free radicals, antioxidants and squamous cell carcinoma (SCC). Oxygen radical absorbance capacity (ORAC) method is used to measure antioxidant capacity versus oxygen free radicals. There is no report on the application of ORAC to evaluate salivary antioxidant capacity in patients with head and neck SCC. This study investigated the relation between total antioxidant capacity of saliva, measured with ORAC method, and the incidence, location, size and histopa...περισσότερα »
Letter: self-pay behaviour patients with chronic hepatitis C who required direct acting anti-viral urgently in a real-world setting
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Letter: aberrant GSTP1 promoter methylation in acute-on-chronic hepatitis B liver failure – authors’ reply
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Letter: ileal bile acid transporter inhibition – is there a potential for drug–drug interaction?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Letter: long-term use of proton pump inhibitors and risk of neuroendocrine tumours
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Letter: aberrant GSTP1 promoter methylation in acute-on-chronic hepatitis B liver failure
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Editorial: PPI-responsive oesophageal eosinophilia and long-term PPI treatment – authors’ reply
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Issue Information
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
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Acid-sensing ion channel 1a induces AMPA receptor plasticity: a link between acidotoxicity and excitotoxicity in hippocampal CA1 neurons
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
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Context-dependent use of muscle spindles for human position sense
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
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Associations of Inter- and Intraday Temperature Change With Mortality
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
In this study we evaluated the association between temperature variation and mortality and compared it with the contribution due to mean daily temperature in 6 cities with different climates. Quasi-Poisson time series regression models were applied to estimate the associations (relative risk and 95% confidence interval) of mean daily temperature (99th and 1st percentiles, with […]
Chimpanzee adenovirus and MVA-vectored respiratory syncytial virus vaccine is safe and expands humoral and cellular immunity in adults
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Subregional differences in the generation of fast network oscillations in the rat medial prefrontal cortex (mPFC) in vitro
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Physiological increases in lactate inhibit intracellular calcium transients, acidify myocytes and decrease force in term pregnant rat myometrium
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Acid‐sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Body Size, Metabolic Factors, and Risk of Endometrial Cancer in Black Women
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Total and abdominal obesity, as well as metabolic factors such as type 2 diabetes, have been associated with a higher risk of endometrial cancer in white women. It remains unclear to what extent these factors influence the risk of endometrial cancer in black women. We followed 47,557 participants from the Black Women’s Health Study for […]
Analysis of the functional WT1-specific T-cell repertoire in healthy donors reveals a discrepancy between CD4+ and CD8+ memory formation
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Subregional differences in the generation of fast network oscillations in the rat medial prefrontal cortex (mPFC) in vitro
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The Journal of Physiology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PWb3VV via IFTTT
Jump, Hop, or Skip: Modeling Practice Effects in Studies of Determinants of Cognitive Change in Older Adults
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Improvements in cognitive test scores upon repeated assessment due to practice effects (PEs) are well documented, but there is no empirical evidence on whether alternative specifications of PEs result in different estimated associations between exposure and rate of cognitive change. If alternative PE specifications produce different estimates of association between an exposure and rate of […]
Analysis of the functional WT1-specific T-cell repertoire in healthy donors reveals a discrepancy between CD4+ and CD8+ memory formation
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Immunology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/213KMZu via IFTTT
Chimpanzee adenovirus and MVA-vectored respiratory syncytial virus vaccine is safe and expands humoral and cellular immunity in adults
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Physiological increases in lactate inhibit intracellular calcium transients, acidify myocytes and decrease force in term pregnant rat myometrium
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The Journal of Physiology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PWb38j via IFTTT
Acid‐sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The Journal of Physiology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/213KNwh via IFTTT
Subregional differences in the generation of fast network oscillations in the rat medial prefrontal cortex (mPFC) in vitro
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The Journal of Physiology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PWb3VV via IFTTT
Analysis of the functional WT1-specific T-cell repertoire in healthy donors reveals a discrepancy between CD4+ and CD8+ memory formation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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The effectiveness of pharmaceutical interventions for obesity: weight loss with orlistat and sibutramine in a United Kingdom population-based cohort
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
British Journal of Clinical Pharmacology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PWb2Bk via IFTTT
Assessment of salivary total antioxidant capacity in patients with primary untreated head and neck squamous cell carcinoma with ORAC
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background Oxidative DNA damage leads to abnormalities in endogenous cellular processes and constitutes a direct link between free radicals, antioxidants and squamous cell carcinoma (SCC). Oxygen radical absorbance capacity (ORAC) method is used to measure antioxidant capacity versus oxygen free radicals. There is no report on the application of ORAC to evaluate salivary antioxidant capacity […]
Cell phone use is associated with an inflammatory cytokine profile of parotid gland saliva
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background There is controversy on the effects of the non-ionizing radiation emitted by cell phones on cellular processes and the impact of such radiation exposure on health. The purpose of this study was to investigate whether cell phone use alters cytokine expression in the saliva produced by the parotid glands. Methods Cytokine expression profile was […]
Clinical, biophysical, immunohistochemical, and in vivo reflectance confocal microscopy evaluation of the response of subjects with sensitive skin to home-use fractional non-ablative photothermolysis device
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background Fractional photothermolysis using professional devices is a well-accepted and a widely used technique for skin rejuvenation. Recently, the technology has also been implemented in devices for home-use. Yet, a subpopulation of consumers exists that reacts excessively to this stimulation and reports “sensitive skin” (SS). Objective The goal of this study was to evaluate the […]
Therapeutic antioxidant and anti-inflammatory effects of laser acupuncture on patients with rheumatoid arthritis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background and Objective The laser acupuncture has many potential therapeutic effects. Currently, they are not evaluated for their therapeutic effects on rheumatoid arthritis (RA) patients. The aim of this study was to investigate the effects of laser acupuncture on the oxidative and antioxidative markers, as well as the inflammatory markers and disease activity of RA […]
Assessment of salivary total antioxidant capacity in patients with primary untreated head and neck squamous cell carcinoma with ORAC
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background Oxidative DNA damage leads to abnormalities in endogenous cellular processes and constitutes a direct link between free radicals, antioxidants and squamous cell carcinoma (SCC). Oxygen radical absorbance capacity (ORAC) method is used to measure antioxidant capacity versus oxygen free radicals. There is no report on the application of ORAC to evaluate salivary antioxidant capacity […]
Cell phone use is associated with an inflammatory cytokine profile of parotid gland saliva
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background There is controversy on the effects of the non-ionizing radiation emitted by cell phones on cellular processes and the impact of such radiation exposure on health. The purpose of this study was to investigate whether cell phone use alters cytokine expression in the saliva produced by the parotid glands. Methods Cytokine expression profile was […]
Clinical, biophysical, immunohistochemical, and in vivo reflectance confocal microscopy evaluation of the response of subjects with sensitive skin to home-use fractional non-ablative photothermolysis device
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background Fractional photothermolysis using professional devices is a well-accepted and a widely used technique for skin rejuvenation. Recently, the technology has also been implemented in devices for home-use. Yet, a subpopulation of consumers exists that reacts excessively to this stimulation and reports “sensitive skin” (SS). Objective The goal of this study was to evaluate the […]
Therapeutic antioxidant and anti-inflammatory effects of laser acupuncture on patients with rheumatoid arthritis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background and Objective The laser acupuncture has many potential therapeutic effects. Currently, they are not evaluated for their therapeutic effects on rheumatoid arthritis (RA) patients. The aim of this study was to investigate the effects of laser acupuncture on the oxidative and antioxidative markers, as well as the inflammatory markers and disease activity of RA […]
Mammographie bei Frauen über 75 Jahren
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Literatur kommentiert Die vorgestellte Studie will die Frage klären: Verbessert sich die Prognose für symptomfreie ältere Frauen mit einem durch Mammographie detektiertem Mammakarzinom? from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PLJNWB via IFTTT
Assessment of salivary total antioxidant capacity in patients with primary untreated head and neck squamous cell carcinoma with ORAC
Background Oxidative DNA damage leads to abnormalities in endogenous cellular processes and constitutes a direct link between free radicals, antioxidants and squamous cell carcinoma (SCC). Oxygen radical absorbance capacity (ORAC) method is used to measure antioxidant capacity versus oxygen free radicals. There is no report on the application of ORAC to evaluate salivary antioxidant capacity in patients with head and neck SCC. This study investigated the relation between total antioxidant capacity of saliva, measured with ORAC method, and the incidence, location, size and histopa...περισσότερα »
Cell phone use is associated with an inflammatory cytokine profile of parotid gland saliva
Background There is controversy on the effects of the non-ionizing radiation emitted by cell phones on cellular processes and the impact of such radiation exposure on health. The purpose of this study was to investigate whether cell phone use alters cytokine expression in the saliva produced by the parotid glands. Methods Cytokine expression profile was determined by enzyme linked immuno sorbent assay (ELISA) in the saliva produced by the parotid glands in healthy volunteers, and correlated with self-reported cell phone use and laterality. Results The following parameters were ...περισσότερα »
Acid-sensing ion channel 1a induces AMPA receptor plasticity: a link between acidotoxicity and excitotoxicity in hippocampal CA1 neurons
from #Medicine via ola Kala on Inoreader http://ift.tt/1VfK1ZR Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Context-dependent use of muscle spindles for human position sense
from #Medicine via ola Kala on Inoreader http://ift.tt/1ohRvB8 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Utilization of Speech-Language Pathology and Audiology Services in Stroke Patients.
Authors: Fridriksson J, Frank E, Vesselinov R Abstract The purpose of this study was to investigate biographical and medical factors associated with utilization of speech-language pathology and audiology services provided to stroke patients in the hospital setting. Moreover, the study sought to identify possible sub-groups of stroke patients that might be under served by speech-language… Continue reading Utilization of Speech-Language Pathology and Audiology Services in Stroke Patients.
The Effects of Topic Knowledge on Intelligibility and Lexical Segmentation in Hypokinetic and Ataxic Dysarthria.
This study examined the benefit of providing listeners with the topic of some phases produced by speakers with either hypokinetic or ataxic dysarthria. Total and topic word accuracy, topic-related substitutions, and lexical boundary errors were calculated from the listener transcripts. Data were compared with those who underwent a familiarization process (reported by Liss, Spitzer, Caviness,… Continue reading The Effects of Topic Knowledge on Intelligibility and Lexical Segmentation in Hypokinetic and Ataxic Dysarthria.
