Head and Neck Medicine by Alexandros G.Sfakianakis: 07/20/16

Τετάρτη 20 Ιουλίου 2016

OtoRhinoLaryngology & Medicine,New Articles,July 21st,2016

Parenteral Nutrition Basics for the Clinician Caring for the Adult Patient

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 λεπτό

Parenteral nutrition (PN) is a life-sustaining therapy providing nutrients to individuals with impaired intestinal tract function and enteral access challenges. It is one of the most complex prescriptions written routinely in the hospital and home care settings. This article is to aid the nutrition support clinician in the safe provision of PN, including selecting appropriate… Continue reading Parenteral Nutrition Basics for the Clinician Caring for the Adult Patient

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 λεπτό

Jean Anderson Eloy and Michael Setzen from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/2aavn6S via IFTTT

Contributors

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 λεπτό

JEAN ANDERSON ELOY, MD, FACS from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/2acJLyv via IFTTT

Balloon Catheter Dilation of the Frontal Sinus Ostium

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 λεπτό

The decision to operate on the frontal sinus is based on persistent symptoms that have been refractory to appropriate medical therapy with associated radiographic evidence of disease by computed tomography. There is currently no evidence to support operating on radiographically negative frontal sinuses, regardless of the availability of technology or site of service options. There… Continue reading Balloon Catheter Dilation of the Frontal Sinus Ostium

Standard Endoscopic Approaches in Frontal Sinus Surgery

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 λεπτό

The mainstay of frontal sinus surgery for chronic rhinosinusitis is to achieve and maintain an adequate frontal outflow tract. Using a stepwise approach and identifying critical endoscopic anatomic landmarks, to minimize complications and obtain long-term good endoscopic surgical results, should achieve this. The goal is to relieve the patient’s symptoms, restore functional mucociliary flow, achieve… Continue reading Standard Endoscopic Approaches in Frontal Sinus Surgery

Evaluation and Decision Making in Frontal Sinus Surgery

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 λεπτό

Management of frontal sinusitis can be challenging for even the most experienced otolaryngologists. A thorough understanding of the anatomy and pathophysiology of the frontal sinus is essential to properly manage disease affecting the frontal sinus. Being able to distinguish acute viral from acute bacterial and acute from chronic sinusitis is crucial because these distinctions guide… Continue reading Evaluation and Decision Making in Frontal Sinus Surgery

Active music therapy approach in amyotrophic lateral sclerosis: a randomized-controlled trial.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 λεπτό

This randomized controlled study assessed the efficacy of active music therapy (AMT) on anxiety, depression, and quality of life in amyotrophic lateral sclerosis (ALS). Communication and relationship during AMT treatment were also evaluated. Thirty patients were assigned randomly to experimental [AMT plus standard of care (SC)] or control (SC) groups. AMT consisted of 12 sessions… Continue reading Active music therapy approach in amyotrophic lateral sclerosis: a randomized-controlled trial.

Management of Frontal Sinus Cerebrospinal Fluid Leaks and Encephaloceles

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 λεπτό

Encephaloceles and cerebrospinal fluid (CSF) leaks of the frontal sinus may result from congenital, traumatic, spontaneous, or neoplastic causes. Paramount to success is adequate preoperative planning with accurate history, physical exam, endoscopy, imaging, and testing to confirm location of the leak and origin of the disease. Generally, frontal sinus CSF leaks may be addressed endoscopically… Continue reading Management of Frontal Sinus Cerebrospinal Fluid Leaks and Encephaloceles

Comparison of the effects of mirror therapy and electromyography-triggered neuromuscular stimulation on hand functions in stroke patients: a pilot study.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 λεπτό

To determine the effectiveness of mirror therapy and electromyography (EMG)-triggered neuromuscular stimulation on improvement of functions of the upper extremity in patients with subacute stroke in comparison with conventional therapy as well as to evaluate the advantage of each treatment over another, we conducted a prospective, randomized, and controlled trial involving 24 patients with ischemic… Continue reading Comparison of the effects of mirror therapy and electromyography-triggered neuromuscular stimulation on hand functions in stroke patients: a pilot study.

Functional Diversity of Cytotoxic tRNase/immunity Protein Complexes from Burkholderia pseudomallei Protein Structure and Folding

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 λεπτό

Contact-dependent growth inhibition (CDI) is a wide-spread mechanism of inter-bacterial competition. CDI+ bacteria deploy large CdiA effector proteins, which carry variable C-terminal toxin domains (CdiA-CT). CDI+ cells also produce CdiI immunity proteins that specifically neutralize cognate CdiA-CT toxins to prevent auto-inhibition. Here, we present the crystal structure of the CdiA-CT/CdiIE479 toxin/immunity protein complex from Burkholderia… Continue reading Functional Diversity of Cytotoxic tRNase/immunity Protein Complexes from Burkholderia pseudomallei Protein Structure and Fo... περισσότερα »

Light and the City: Breast Cancer Risk Factors Differ Between Urban and Rural Women in Israel

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 λεπτό

Women are exposed to indoor and outdoor artificial light at night (ALAN) in urban and rural environments. Excessive exposure to hazardous ALAN containing short wavelength light may suppress pineal melatonin production and lead to an increased breast cancer (BC) risk. Our objective was to address the differences in BC risks related to light exposure in […]

Jak1-STAT3 critical effectors of USP6 during tumorigenesis

Bone and soft tissue tumors are relatively poorly understood, hampering the development of effective therapies. Here we report a role for the ubiquitin-specific protease 6 (USP6)/TRE17 oncogene, which is overexpressed upon chromosome translocation in various human tumors, in aneurysmal bone cysts and the related benign lesion nodular fasciitis (NF). Ectopic expression of USP6 is known […]

Publication date: August 2016 Source:European Journal of Vascular and Endovascular Surgery, Volume 52, Issue 2 from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2aaxkQS via IFTTT

Selected Abstracts from the August Issue of the Journal of Vascular Surgery

Editorial Board

Going Beyond Current AAA Neck Angulation Limitations of the Ovation Ultra-low Profile Polymer-filled Stent Graft

Publication date: August 2016 Source:European Journal of Vascular and Endovascular Surgery, Volume 52, Issue 2 Author(s): C.V. Ioannou, D.K. Tsetis from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2acLzYi via IFTTT

Not to be Missed

Publication date: Available online 19 July 2016 Source:European Journal of Vascular and Endovascular Surgery Author(s): M. Elkawafi, S. Rajagopalan from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2aaxk3m via IFTTT

Multiple Choice Questions

Abstracts from Issue 31 of EJVES Short Reports

Forthcoming Events

Registration of cone beam computed tomography data and intraoral surface scans – A prerequisite for guided implant surgery with CAD/CAM drilling guides

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 11 δευτερόλεπτα

Abstract Objectives Guided implant surgery (GIS) is performed with drilling guides that are produced on the virtual tooth model using CAD/CAM technology. The prerequisite for this workflow is the alignment of patients cone beam computed tomography CBCT and surface scan (registration). Dental restorations may cause deteriorating imaging artifacts in CBCT data, which in turn can have an impact on the registration process. The influence of the user and the preprocessing of data and of image artifacts on the registration accuracy were examined. Material and Methods CBCT data and int... περισσότερα »

PIN1 Suppresses the Hepatic Differentiation of Pulp Stem Cells via Wnt3a

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 11 δευτερόλεπτα

This study aimed to investigate the role of PIN1 on the hepatic differentiation of human dental pulp stem cells (hDPSCs) and its signaling pathway, as well as the potential therapeutic effects of hDPSC transplantation and PIN1 inhibition on CCl4 (carbon tetrachloride)–induced liver fibrosis in mice. The in vitro results showed that hepatic differentiation was suppressed by infection with adenovirus-PIN1 and promoted by PIN1 inhibitor juglone via the downregulation of Wnt3a and β-catenin. Compared with treatment with either hDPSC transplantation or juglone alone, the combination of... περισσότερα »

A Cluster-Randomized, Community-Based, Tribally Delivered Oral Health Promotion Trial in Navajo Head Start Children

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 11 δευτερόλεπτα

The authors tested the effectiveness of a community-based, tribally delivered oral health promotion (OHP) intervention (INT) at reducing caries increment in Navajo children attending Head Start. In a 3-y cluster-randomized trial, we developed an OHP INT with Navajo input that was delivered by trained Navajo lay health workers to children attending 52 Navajo Head Start classrooms (26 INT, 26 usual care [UC]). The INT was designed as a highly personalized set of oral health–focused interactions (5 for children and 4 for parents), along with 4 fluoride varnish applications delivered ... περισσότερα »

Management of Frontal Sinus Cerebrospinal Fluid Leaks and Encephaloceles

Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Encephaloceles and cerebrospinal fluid (CSF) leaks of the frontal sinus may result from congenital, traumatic, spontaneous, or neoplastic causes. Paramount to success is adequate preoperative planning with accurate history, physical exam, endoscopy, imaging, and testing to confirm location of the leak and origin of the disease. Generally, frontal sinus CSF leaks may be addressed endoscopically with favorable anatomy, proper surgical technique, and appropriate equipment. Open surgical approaches (eg, osteoplastic flap) are often required for superior/lateral defects or if the surge... περισσότερα »

Forthcoming Issues

Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Endoscopic Ear and Eustachian Tube Surgery http://ift.tt/2aawbZu

CME Accreditation Page

Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

http://ift.tt/2acKkbo

Index

Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Note: Page numbers of article titles are in boldface type. http://ift.tt/2aaw4gv

Management of Frontal Sinus Tumors

Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

The most common primary tumors of the frontal sinus are osteomas and inverted papillomas, although a variety of other tumors involving this space have been reported. With the advent of new surgical techniques and instrumentation, an endoscopic approach to this region has become feasible. The preoperative assessment and decision making must take into account the complexity of frontal sinus anatomy, tumor type, tumor location, and associated attachments. These procedures allow adequate visualization, tumor removal, and postoperative monitoring, and preserve fairly normal sinus funct... περισσότερα »

Outcomes After Frontal Sinus Surgery

Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Endoscopic sinus surgery is an effective intervention at improving quality of life for patients with medically refractory chronic rhinosinusitis. The evidence supporting frontal sinusotomy is limited to single institution case series. However, the data for Draf IIa frontal sinusotomy do demonstrate that most patients experience lasting frontal sinus patency on postoperative endoscopic examination and improvements in quality of life. Salvage endoscopic frontal sinus surgery via a Draf III shows high rates of neo-ostium patency and subjective improvements in symptoms at a 2-year time... περισσότερα »

Copyright

Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Elsevier http://ift.tt/2acJUSs

Frontal Sinus Disease: Contemporary Management

Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA http://ift.tt/2aavSxI

Frontal Sinus Disease: Contemporary Management

Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

Rhinosinusitis affects an estimated 1 in 7 adults in the United States. Otolaryngologists are intimately involved in the care of patients with rhinosinusitis and other upper airway inflammatory conditions through medical management and procedures such as endoscopic sinus surgery. The frontal sinus is considered the most difficult of the paranasal sinuses to manage. Frontal sinusitis is typically treated medically, with surgical interventions reserved for the most recalcitrant cases. Both private practitioners and academic physicians manage frontal sinusitis. http://ift.tt/2acKn7g

Open Frontal Sinus Surgery

Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα

In this article, the historical context and current application of external frontal sinus procedures are discussed. In particular, the frontal trephine, frontoethmoidectomy, and osteoplastic flap are described. http://ift.tt/2aaw4go

Extracorporal Shock Wave Therapy as a Delay Procedure to Improve Viability of Zone 4

otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα

4: An Experimental Study in a Rat TRAM Flap Model: Abstract Background: The purpose of this study was to test our hypothesis that preoperative application of radial extracorporeal shock wave therapy (rESWT) as a delay procedure would improve the survival of zone 4 of transverse rectus abdominis musculocutaneous (TRAM) flap and reduce the resulting necrotic […]

Amifostine Treatment Mitigates the Damaging Effects of Radiation on Distraction Osteogenesis

in the Murine Mandible: Abstract: According to the American Society of Clinical Oncology, in 2012, more than 53,000 new cases of head and neck cancers (HNCs) were reported in the United States alone and nearly 12,000 deaths occurred relating to HNC. Although radiotherapy (XRT) has increased survival, the adverse effects can be unrelenting and their […]

Effects of Rat Bone Marrow–Derived Mesenchymal Stem Cells and Demineralized Bone Matrix on Cranial Bone Healing

Effects of Rat Bone Marrow–Derived Mesenchymal Stem Cells and Demineralized Bone Matrix on Cranial Bone Healing: Background: Studies in tissue engineering about mesenchymal stem cells (MSCs) provide promising results for bone regeneration. The aim of this study was to evaluate the effects of rat bone marrow–derived MSCs (rMSCs) alone and when combined with demineralized bone […]

Reconstruction of Large Cheek Defect With/Without Sideburn Using Malar-Posterior Auricular-Cervico Flap

Reconstruction of Large Cheek Defect With/Without Sideburn Using Malar-Posterior Auricular-Cervico Flap: Abstract: The cheek region is the most common site for malignant tumor occurrence and the treatment of malignant skin tumor requires extensive local excision. Many previous reports have covered methods of reconstruction using local flaps for skin defects in the cheek region. In this […]

Inter-genomic DNA Exchanges and Homoeologous Gene Silencing Shaped the Nascent Allopolyploid Coffee Genome (Coffea arabica L.)

Alexandros G. SfakianakisστοEvolution of a geneΠριν από 27 δευτερόλεπτα

Allopolyploidization is a biological process that has played a major role in plant speciation and evolution. Genomic changes are common consequences of polyploidization, but their dynamics over time are still poorly understood. *Coffea arabica*, a recently formed allotetraploid, was chosen to study genetic changes that accompany allopolyploid formation. Both RNA-seq and DNA-seq data were generated from two *C. arabica* genetically distant accessions. Genomic structural variation was investigated using *C. canephora*, one of its diploid progenitors, as reference genome. The fate of... περισσότερα »

A Genomic Analysis of Factors Driving lincRNA Diversification: Lessons from Plants

Alexandros G. SfakianakisστοEvolution of a geneΠριν από 27 δευτερόλεπτα

Transcriptomic analyses from across eukaryotes indicate that most of the genome is transcribed at some point in the developmental trajectory of an organism. One class of these transcripts is termed long intergenic noncoding RNAs (lincRNAs). Recently, attention has focused on understanding the evolutionary dynamics of lincRNAs, particularly their conservation within genomes. Here, we take a comparative genomic and phylogenetic approach to uncover factors influencing lincRNA emergence and persistence in the plant family Brassicaceae, to which A. thaliana belongs. We searched ten gen... περισσότερα »

Injectable Aorta Tissue Paste for Vocal Fold Medialization: Residence Time, Biocompatibility, and Comparison to Predicates in a Guinea Pig Subdermal Model

στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 32 δευτερόλεπτα

Objectives: Aortic homografts integrate well with laryngeal tissue when used in reconstructive surgery. It was hypothesized that a paste of aortic homograft, rich in slow-to-degrade elastin, would compare favorably in residence time and biocompatibility to predicate materials used for vocal fold injection-medialization. Methods: An injectable aorta paste (AP) was made by pulverizing aortic homografts at –196°C (cryomilling). To assess residence time and biocompatibility, 0.3 cc was injected subdermally in guinea pigs (n = 3 per 2-, 4-, 8-, 16-, 24-week time points) followed by hist... περισσότερα »

Otopolyposis With Middle Ear Allergic Mucin in a Patient With Allergic Fungal Rhinosinusitis

στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 32 δευτερόλεπτα

Objective: The purpose of this study is to report a case of otopolyposis and middle ear allergic mucin in a patient with allergic fungal rhinosinusitis (AFRS) and no history of middle ear disease and introduce these as possible otologic manifestations of the AFRS. Methods: A case of a 31-year-old female with the aforementioned findings is reported. A review of the pertinent literature was performed. Results: We report a case of a 31-year-old female with a history of AFRS but no history of middle ear disease or hearing loss who presented to our institution complaining of aural fulln... περισσότερα »

The added value of an electronic monitoring and alerting system in the management of medication-overuse headache: A controlled multicentre study

στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 32 δευτερόλεπτα

Background Medication-overuse headache (MOH) is a chronic disabling condition associated with a high rate of relapse. Methods We evaluated whether the adoption of electronic-assisted monitoring, advice and communication would improve the outcome over a follow-up of 6 months in a controlled, multicentre, multinational study conducted in six headache centres located in Europe and Latin America. A total of 663 MOH subjects were enrolled and divided into two groups: the Comoestas group was monitored with an electronic diary associated with an alert system and a facilitated communicatio... περισσότερα »

An Innovative Operative Method for Correction of Tracheal Stenosis

στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 32 δευτερόλεπτα

Abstract This is a case of failed attempt of hanging, resulted into cervical injury & amp; injury to the trachea. Patient was put on the ventilator for respiratory support for long period. Poor recovery of the patient resulted into prolong tracheostomy tube. Combine effect of all resulted into suprastomal tracheal stenosis. Due to complexity of the problem a novel method was customized to correct the tracheal stenosis. Strap muscle (Sternohyoid & Sternothyroid) was raised as a flap; free cartilage was sandwiched in between and sutured to the created tracheal defect. Bovine collagen was ... περισσότερα »

Factors predisposing to worsening of sleep apnea in response to fluid overload in men

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

• Pre-sleep bioimpedance measures and NC can predict susceptibility to fluid overload• Men with larger pharyngeal tissue may be more susceptible to OSA with fluid overload• Fluid overloading results in more fluid accumulation in the neck http://ift.tt/29WNMUY

Video-polysomnographic documentation of non−rapid eye movement sleep parasomnia followed by rapid eye movement sleep behavior disorder: A parasomnia overlap disorder?

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

Parasomnia overlap disorder (POD) is the coexistence of non−rapid eye movement (NREM) parasomnia (eg, sleepwalking, confusional arousals) and rapid eye movement (REM) sleep behavior disorder (RBD) in the same individual [1]. POD can be idiopathic or associated with conditions such as narcolepsy, Moebius syndrome, and brain structural lesions [1-5]. In contrast to idiopathic RBD, the risk of phenoconversion to a neurodegenerative disease is unknown in POD [5]. POD is rare, and only a few cases have been confirmed by video-polysomnography (VPSG). http://ift.tt/2avQoI3

Catathrenia, a REM predominant disorder of arousal?

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

• Catathrenia is an uncommon sleep disorder with a characteristic breathing pattern, often accompanied by groaning.• It usually arises from REM sleep and is generally preceded by an arousal from sleep.• While generally considered a social nuisance, a high proportion of catathrenia patients also report daytime sleepiness.• CPAP and sleep consolidating medication may improve symptoms, but are limited by low patient acceptance. http://ift.tt/29WNY6R

Application of digital surgical guides in mandibular resection and reconstruction with fibula flaps

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

Surgical guides have been used widely in maxillofacial surgery. Details of the types of digital surgical guide used in mandibular resection and reconstruction with fibula flaps at the authors' institution are presented in this article. Three patients diagnosed with mandibular ameloblastoma underwent mandibular resection and reconstruction with fibula flaps using surgical guides for assistance. These digital surgical guides included a mandibular osteotomy guide, a fibular osteotomy guide, and a mandibular fixation guide. http://ift.tt/2aa7egG

Roles of Mas-related G protein–coupled receptor X2 on mast cell–mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

Mast cells (MCs), which are granulated tissue-resident cells of hematopoietic lineage, contribute to vascular homeostasis, innate/adaptive immunity, and wound healing. However, MCs are best known for their roles in allergic and inflammatory diseases, such as anaphylaxis, food allergy, rhinitis, itch, urticaria, atopic dermatitis, and asthma. In addition to the high-affinity IgE receptor (FcεRI), MCs express numerous G protein–coupled receptors (GPCRs), which are the largest group of membrane receptor proteins and the most common targets of drug therapy. http://ift.tt/29VXP9S

Sinus pericranii, petrosquamosal sinus and extracranial sigmoid sinus: Anatomical variations to consider during a retroauricular approach

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

Lateral and sigmoid sinus malformations are uncommon and dangerous anatomical variations that surgeons may encounter when performing a retroauricular approach. We report three cases of rare temporal bone venous sinus anomalies seen in patients who underwent cochlear implant surgery. The first patient had a diagnosis of CHARGE syndrome and presented a bilateral persistent petrosquamosal sinus with sigmoid sinus agenesis, which made mastoidectomy for cochlear implantation difficult. The second patient presented an anomalous venous lake in the occipital region, which communicated the... περισσότερα »

Corrigendum to “DNA methylation markers for oral pre-cancer progression: A critical review” [Oral Oncology 53 (2015) 1–9]

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

The authors regret the error published in Introduction Section on Page 1, Line 7: "Over a million new cases are reported every year from more developed regions of the World [1], more so among young adults [4,5]". Please note the corrected statement with respect to the above mentioned line: "Over a hundred thousand new cases are reported every year from more developed regions of the World [1], more so among young adults [4,5]". http://ift.tt/2aacQsB

Majantol Is a Relevant Fragrance Allergy in Adolescent Children

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

[image: image]No abstract available http://ift.tt/2avmZ0L

Essential Oils: Emerging “Medicaments”

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

[image: image]No abstract available http://ift.tt/2avm3cG

Essential Oils, Part III: Chemical Composition

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

[image: image]Data on the chemistry of essential oils which have caused contact allergy are provided. The largest group of chemicals found in essential oils consists of terpenes. The number of identified components usually ranges from 100 to 250, but in some oils (lavender, geranium, rosemary) 450 to 500 chemicals have been found. Many chemicals are present in a large number of oils, up to 98% for β-caryophyllene and 97% for limonene. Chemicals that are important constituents of >20 oils are limonene, linalool, and α-pinene. In many essential oils, there are 2 to 5 components which ... περισσότερα »

Self-Assessment

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

No abstract available http://ift.tt/29WoDd7

Essential Oils, Part IV: Contact Allergy

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

[image: image]Nearly 80 essential oils (including 2 jasmine absolutes) have caused contact allergy. Fifty-five of these have been tested in consecutive patients suspected of contact dermatitis, and nine (laurel, turpentine, orange, tea tree, citronella, ylang-ylang, sandalwood, clove, and costus root) showed greater than 2% positive patch test reactions. Relevance data are generally missing or inadequate. Most reactions are caused by application of pure oils or high-concentration products. The clinical picture depends on the responsible product. Occupational contact dermatitis may o... περισσότερα »

Contact Dermatitis to Formaldehyde From Kissing a Corpse?

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

No abstract available http://ift.tt/2avlQXd

Current Quality-of-Life Tools Available for Use in Contact Dermatitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

[image: image]Contact dermatitis is a common dermatologic condition that can cause significant impairment in patients' overall quality of life (QoL). This impact is separate and potentially more clinically relevant than one's disease "severity" in contact dermatitis and should be consistently addressed by dermatologists. Despite this, QoL tools specific to contact dermatitis are lacking, and there is little consistency in the literature regarding the tool used to evaluate clinical response to therapies. Measurements currently available to evaluate disease-related QoL in contact derm... περισσότερα »

American Contact Dermatitis Society Contact Allergy Management Program App

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

No abstract available http://ift.tt/29WoHJQ

A Pragmatic Approach to Patch Testing Atopic Dermatitis Patients: Clinical Recommendations Based on Expert Consensus Opinion

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

[image: image]Allergic contact dermatitis (ACD) may complicate the clinical course of atopic dermatitis (AD), and patch testing remains the criterion standard for diagnosing ACD. To date, there have been no guidelines or consensus recommendations on when and how to patch test individuals with AD. Failure to patch test when appropriate may result in overlooking an important and potentially curable complicating comorbidity. In this article, we present consensus recommendations regarding when to perform patch testing in the AD patient, best practices, and common pitfalls. Patch testing... περισσότερα »

Sensitization to Rubber Accelerators in Northeastern Italy: The Triveneto Patch Test Database

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

[image: image]Background: Natural and synthetic rubbers containing rubber accelerators are well-known causes of occupational skin disease. Allergic contact dermatitis caused by rubber gloves is frequent and has almost exclusively been attributed to contact sensitization to accelerators. Objective: This study aimed to evaluate the frequency of rubber accelerators sensitization in the population living in northeastern Italy, to find time trend and a correlation with occupations, and to investigate co-sensitization between rubber accelerators. Methods: A population of 23,774 subjects w... περισσότερα »

Vapor Pressure and Predicted Stability of American Contact Dermatitis Society Core Allergens

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

[image: image]Background: Accurate patch testing is reliant on proper preparation of patch test allergens. The stability of patch test allergens is dependent on several factors including vapor pressure (VP). Objective: This investigation reviews the VP of American Contact Dermatitis Society Core Allergens and compares stability predictions based on VP with those established through clinical testing. Methods: Standard references were accessed for determining VP in millimeters of mercury and associated temperature in degrees celsius. If multiple values were listed, VP at temperatures ... περισσότερα »

A Patch Test–Positive Titanium Hypersensitivity Reaction

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

[image: image]No abstract available http://ift.tt/29WojLm

Leather Contains Cobalt and Poses a Risk of Allergic Contact Dermatitis: Cobalt Indicator Solution and X-ray Florescence Spectrometry as Screening Tests

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

[image: image]Background: Cobalt was recently identified in a leather couch responsible for dermatitis. Cobalt content/release in leather in the United States is unknown. We evaluated leather for cobalt content/release and investigated screening methods for identifying cobalt in leather. Methods: One hundred thirty-one leather swatches were screened for cobalt content/release with X-ray fluorescence (XRF) spectrometry and cobalt indicator solution (CIS). Samples with positive screens and 1 negative control were analyzed using inductively-coupled plasma mass spectrometry (ICPMS). Res... περισσότερα »

Contact Urticaria From Occupational Exposure to Formaldehyde

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

No abstract available http://ift.tt/2avmDaB

Cement-Induced Chromate Occupational Allergic Contact Dermatitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

[image: image]Background: Hexavalent chromium in cement is a common cause of occupational allergic contact dermatitis (OACD). Methods: Analysis of patch test data during 1999 to 2013 was done. Patients with cement-induced chromate OACD filled the Dermatology Life Quality Index, graded 1 to 5. Results: Of 4846 consecutive patients who were patch tested, 146 (3%) were chromate-sensitive. Of 46 (31.5%) who presented with chromate OACD, 27 (59%) had cement-induced chromate OACD. The proportion of chromate-sensitive patients with clinically relevant cement exposure increased from 7.7% in... περισσότερα »

Utilization and Geographic Variation of Patch Testing Among Medicare Beneficiaries

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

[image: image]No abstract available http://ift.tt/2avm5kN

Amalgam Contact Allergy in Oral Lichenoid Lesions

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

[image: image]Background: Oral lichenoid lesions (OLLs) cannot be distinguished from oral lichen planus (OLP) except that causative factors can be identified. Amalgam is one of the causative allergens, and replacement may lead to resolution. Objectives: The aim of this study was to determine the prevalence, prognosis, and aggravating factors of amalgam contact allergy in patients with OLLs. Methods: A clinical retrospective and prospective cohort study was carried out at the Dermatology Department, Siriraj Hospital, Mahidol University. In cases with patch test positive for an amalga... περισσότερα »

Reporting Cosmetic Adverse Events to the US Food and Drug Administration

Alexandros G. SfakianakisστοOtoRhinoLaryngology Now by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

No abstract available http://ift.tt/29WoCWy

Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders

Alexandros G. SfakianakisστοΥπνική Άπνοια και Διαταραχές ΎπνουΠριν από 34 δευτερόλεπτα

Melatonin is a physiological hormone involved in sleep timing and is currently used exogenously in the treatment of primary and secondary sleep disorders with empirical evidence of efficacy, but very little evidence from randomised, controlled studies. The aim of this meta-analysis was to assess the evidence base for the therapeutic effects of exogenous melatonin in treating primary sleep disorders.An electronic literature review search of MEDLINE (1950-present) EMBASE (1980- present), PsycINFO (1987- present), and SCOPUS (1990- present), along with a hand-searching of key journals... περισσότερα »

The added value of an electronic monitoring and alerting system in the management of medication-overuse headache: A controlled multicentre study

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα

Uncovering a new principle in chemotherapy resistance in breast cancer

A laboratory study has revealed an entirely unexpected process for acquiring drug resistance that bypasses the need to re-establish DNA damage repair in breast cancers that have mutant BRCA1 or BRCA2 genes. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2aaFzgR via IFTTT

A case of fatal Guillain–Barre syndrome from anti-PD1 monoclonal antibody use

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2abyYEz via IFTTT

Racial differences in head and neck squamous cell carcinomas among non-Hispanic black and white males identified through the National Cancer Database (1998–2012)

Abstract Purpose Head and neck squamous cell carcinoma (HNSCC) incidence is increasing, and evidence suggests survival disparities between non-Hispanic (nH) black and white males. However, temporal changes in HNSCCs and factors contributing to survival differences have not been examined at the national level. Methods National Cancer Database (NCDB) cases were used to evaluate temporal trends […]

Endometrial and cervical cancer patients with multiple sentinel lymph nodes at laparoscopic ICG mapping: How many are enough?

Abstract Purpose The adoption of a sentinel lymph node (SLN) algorithm and the presence of high bilateral detection rates have been associated with increased accuracy of SLN mapping in cervical and endometrial cancer patients. In this context, the significance of the number of SLNs removed has not yet been investigated. The aim of this study […]