Apocrine Hidrocystoma: A Rare Case Report
Abstract Hidrocystoma is a cystic tumor originating from a dilated sweat gland. The tumor is typically small and located predominantly on the face, particularly in the eyelid margins. They are two classical types of hidrocystomas i.e., Apocrine and Eccrine. Apocrine hidrocystomas are cystic lesions that arise from the apocrine secretory coil and Eccrine hidrocystomas represent… Continue reading Apocrine Hidrocystoma: A Rare Case Report
Prevalence and risk factors of intestinal parasitism among two indigenous sub-ethnic groups in Peninsular Malaysia
Abstract Background Intestinal parasitic infections (IPIs) among indigenous people have been widely documented in Malaysia, however, the prevalence of these infections remains high. In the past, most studies have focused on specific species of parasites but polyparasitism has received limited attention. In addition, epidemiology studies on indigenous people tend to consider them as a homogenous… Continue reading Prevalence and risk factors of intestinal parasitism among two indigenous sub-ethnic groups in Peninsular Malaysia
Hematological complications in anorexia nervosa
Hematological complications in anorexia nervosa European Journal of Clinical Nutrition advance online publication, July 20 2016. doi:10.1038/ejcn.2016.115 Authors: E De Filippo, M Marra, F Alfinito, M L Di Guglielmo, P Majorano, G Cerciello, C De Caprio, F Contaldo & F Pasanisi from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/2abCPhO via IFTTT
Toxins, Vol. 8, Pages 224: No Association between Mycotoxin Exposure and Autism: A Pilot Case-Control Study in School-Aged Children
Evaluation of environmental risk factors in the development of autism spectrum disorder (ASD) is needed for a more complete understanding of disease etiology and best approaches for prevention, diagnosis, and treatment. A pilot experiment in 54 children (n = 25 ASD, n = 29 controls; aged 12.4 ± 3.9 years) screened for 87 urinary mycotoxins… Continue reading Toxins, Vol. 8, Pages 224: No Association between Mycotoxin Exposure and Autism: A Pilot Case-Control Study in School-Aged Children
Watch Dr Nicholas McGranahan’s keynote on tumour heterogeneity at #lungcancer16 https://t.co/xjM5eu1YfD @TheCrick https://t.co/75mPhh9F7F
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
Watch Dr Nicholas McGranahan’s keynote on tumour heterogeneity at #lungcancer16 https://t.co/xjM5eu1YfD @TheCrick https://t.co/75mPhh9F7F from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/755721491136802817 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Is adaptive randomisation a healthy direction for clinical trial design? Dr Bishal Gyawali comments in a new blog: https://t.co/sRKDij3B5p
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
Is adaptive randomisation a healthy direction for clinical trial design? Dr Bishal Gyawali comments in a new blog: https://t.co/sRKDij3B5p from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/755703076238024704 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
American Cancer Society endorses HPV vaccine recommendations from CDChttps://t.co/LHIZ3eUmea @AmericanCancer https://t.co/msh8OeKlUl
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
American Cancer Society endorses HPV vaccine recommendations from CDC https://t.co/LHIZ3eUmea @AmericanCancer https://t.co/msh8OeKlUl from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/755696310678945792 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Pelvic organ prolapse
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
What you need to knowPelvic organ prolapse can substantially affect a woman’s quality of lifeThe most consistent risk factors are vaginal childbirth, advancing age, increasing body mass index, and… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29Tcp3U via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
I never asked to be ICE’d
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
A while ago I was talking with friends about the visit one of us recently had to make to her general practitioner.“Don’t you hate it when they ask you what you think is wrong?” she asked. “I was… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29TnWUG via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel […]
Margaret McCartney: The unacceptable cost of non-NHS screening
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
The NHS is making impossible choices about what to fund. And yet, routinely, doctors are expected to pick up the pieces from non-NHS services.I’ve written before about my distaste for private health… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29TcVic via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
We should investigate social media’s value properly
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
Social media have transformed traditional concepts of knowledge translation,1 2 and the rapid rise in conference “hashtags” creates its own knowledge gap. For some, this has resulted in a distorted… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29To9ra via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
England must support its community hospitals
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
Appleby highlights the plight of acute hospital patients with delayed discharge because of waiting for assessments and transfers to other NHS facilities.1 We note an overlooked and neglected NHS… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29TcODe via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Scaled up general practice organisations do not provide better quality of care, report says
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
General practices that pool their resources in bigger partnerships or by working together in federations may see some gains in operational efficiency and prescribing but there were few signs that… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29ToAl0 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Viruses, Vol. 8, Pages 199: N-Terminal Domain of Feline Calicivirus (FCV) Proteinase-Polymerase Contributes to the Inhibition of Host Cell Transcription
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 5 δευτερόλεπτα
Feline Calicivirus (FCV) infection results in the inhibition of host protein synthesis, known as “shut-off”. However, the precise mechanism of shut-off remains unknown. Here, we found that the FCV strain 2280 proteinase-polymerase (PP) protein can suppress luciferase reporter gene expression driven by endogenous and exogenous promoters. Furthermore, we found that the N-terminal 263 aa of […]
Viruses, Vol. 8, Pages 199: N-Terminal Domain of Feline Calicivirus (FCV) Proteinase-Polymerase Contributes to the Inhibition of Host Cell Transcription
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Feline Calicivirus (FCV) infection results in the inhibition of host protein synthesis, known as “shut-off”. However, the precise mechanism of shut-off remains unknown. Here, we found that the FCV strain 2280 proteinase-polymerase (PP) protein can suppress luciferase reporter gene expression driven by endogenous and exogenous promoters. Furthermore, we found that the N-terminal 263 aa of […]
Toxins, Vol. 8, Pages 224: No Association between Mycotoxin Exposure and Autism: A Pilot Case-Control Study in School-Aged Children
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Evaluation of environmental risk factors in the development of autism spectrum disorder (ASD) is needed for a more complete understanding of disease etiology and best approaches for prevention, diagnosis, and treatment. A pilot experiment in 54 children (n = 25 ASD, n = 29 controls; aged 12.4 ± 3.9 years) screened for 87 urinary mycotoxins […]
Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Abstract Background Mantle cell lymphoma (MCL) is an aggressive disease with short median survival. Molecularly, MCL is defined by the t(11;14) translocation leading to overexpression of the CCND1 gene. However, recent data show that the neural transcription factor SOX11 is a disease defining antigen and several involved signaling pathways have been pin-pointed, among others the […]
Incorporating Yttrium-90 trans-arterial radioembolization (TARE) in the treatment of metastatic pancreatic adenocarcioma: a single center experience
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Abstract Background The purpose of this retrospective study was to evaluate the efficacy of incorporating trans-arterial radioembolization (TARE) with systemic chemotherapy in the treatment of liver-dominant metastatic pancreatic ductal adenocarcinoma, with the aim of destroying liver metastases and improving patient outcomes. Methods We retrospectively evaluated 16 patients with liver-dominant metastatic pancreatic ductal adenocarcinoma who underwent […]
MICAL1 controls cell invasive phenotype via regulating oxidative stress in breast cancer cells
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Abstract Background Molecules Interacting with CasL (MICAL1), a multidomain flavoprotein monoxygenase, is strongly involved in the mechanisms that promote cancer cell proliferation and survival. Activation of MICAL1 causes an up-regulation of reactive oxygen species (ROS) in HeLa cells. ROS can function as a signaling molecule that modulates protein phosphorylation, leading to malignant phenotypes of cancer […]
The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Abstract Background Formyl peptide receptor 1 (FPR1) is a G protein-coupled receptor mainly expressed by the cells of myeloid origin, where it mediates the innate immune response to bacterial formylated peptides. High expression of FPR1 has been detected in various cancers but the function of FPR1 in tumorigenesis is poorly understood. Methods Expression of FPR1 […]
AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Abstract Background Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have become the standard care of patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC), development of acquired resistance is inevitable. A secondary mutation of threonine 790 (T790M) is associated with approximately half of the cases of acquired resistance. Strategies or agents to […]
Serum MMP7, MMP10 and MMP12 level as negative prognostic markers in colon cancer patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Abstract Background Matrixmetalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases which are involved in angiogenesis, tumor invasion and metastatic formation. Up to date, the prognostic relevance of MMPs in serum of patients with colon cancer remains unknown. Thus, we wanted to assess an expression pattern of MMPs in a homogenous cohort of colon cancer patients […]
Single-institution experience and learning curve with upper airway stimulation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
As upper airway stimulation (UAS) surgical implantation is a new procedure, the authors thought it would be instructive to describe a single-institution’s experience with the inception of a UAS program. The description of our experience at the University of Pennsylvania may be useful for planning purposes when surgeons and sleep medicine physicians are considering program […]
Tumor heterogeneity measured on F-18 fluorodeoxyglucose positron emission tomography/computed tomography combined with plasma Epstein-Barr Virus load predicts prognosis in patients with primary nasopharyngeal carcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Objectives/Hypothesis Plasma Epstein-Barr virus (EBV) DNA concentrations predict prognosis in patients with nasopharyngeal carcinoma (NPC). Recent evidence also indicates that intratumor heterogeneity on F-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) scans is predictive of treatment outcomes in different solid malignancies. Here, we sought to investigate the prognostic value of heterogeneity parameters in patients with primary […]
An Uncommon Case of Adolescent Ovarian Teratoma Incarcerated in Inguinal Hernia
Mature cystic teratoma is the most frequent benign ovarian neoplastic lesion in adolescents and is generally composed of fully differentiated tissue arising from multipotential three germinal layers. It accounts for approximately 50% of benign ovarian tumors in childhood. Rarely, a bilateral, synchronous, or metachronous presentation can be observed, supporting a conservative approach as the first surgical approach. We report a case of an ovarian mature cystic incarcerated in indirect inguinal hernia in a 15-year-old girl undergoing ovary-sparing surgery. To our knowledge this is ... περισσότερα »
Type I Tympanoplasty Meta-Analysis
A Single Variable Analysis: [image: image] Objective: To determine which independent variables influence the efficacy of type I tympanoplasty in adult and pediatric populations. Data Sources: A search of the PubMed database and Cochrane Database of Systematic Reviews using the key words "tympanoplasty OR myringoplasty" from January 1966 to July 2014 was performed. Study Selection: Studies reporting outcomes of myringoplasty or Type I tympanoplasty in primary non-cholesteatomatous chronic tympanic membrane (TM) perforation were included. Data Extraction: Of 4,698 abstracts reviewe... περισσότερα »
Using Balance Function to Screen for Vestibular Impairment in Children With Sensorineural Hearing Loss and Cochlear Implants
Using Balance Function to Screen for Vestibular Impairment in Children With Sensorineural Hearing Loss and Cochlear Implants: [image: image] Abstract Objectives: 1) To determine if bilateral vestibular dysfunction can be predicted by performance on standardized balance tasks in children with sensorineural hearing loss (SNHL) and cochlear implants (CI). 2) To provide clinical recommendations for screening for vestibular impairment in children with SNHL. Study Design: Retrospective cohort study. Setting: Tertiary care pediatric implant center. Patients: Pediatric patients (4.8–... περισσότερα »
TeleAudiology
in the Veterans Health Administration: [image: image]Objective: To assess effectiveness of TeleAudiology for hearing aid services. Study Design: Retrospective case-control. Setting: Ambulatory Veterans Health Administration and Community-Based Outpatient Clinics (CBOCs). Patients: 42,697 veterans who received hearing aids from January through September, 2014. Intervention(s): TeleAudiology (TA) and conventional in-person (IP) audiology care. Main Outcome Measure(s): International Outcome Inventory for Hearing Aids (IOI-HA) outcomes data. The IOI-HA is a 7-item survey used to a... περισσότερα »
Petroclival Chondrosarcoma
A Multicenter Review of 55 Cases and New Staging System Abstract Objective: To analyze clinical outcomes after treatment of petroclival chondrosarcoma and to propose a novel staging system. Study Design: Retrospective case review, 1995 to 2015. Setting: Multicenter study. Patients: Consecutive patients with histopathologically proven petroclival chondrosarcoma. Intervention(s): Microsurgery, endoscopic endonasal surgery, radiation therapy, observation. Main Outcome Measures: Disease- and treatment-associated morbidity, recurrence, mortality. Results: Fifty-five patients (mean ag... περισσότερα »
Ketamine-snorting-induced nasal septum perforation
Ketamine-snorting-induced nasal septum perforation: Keng-Kuang Tsai, MD; Chih-Hung Wang, MD, PhD *Ketamine causes vasoconstriction, and long-term abuse leads to mucosal ischemia, atrophy and, ultimately, necrosis, followed by underlying cartilage or bone destruction.*
Hyper-IgE Syndrome in an Infant
Hyper-IgE Syndrome in an Infant: Background: Hyper–immunoglobulin E syndrome (HIES) is a rare primary immunodeficiency disorder that affects multiple systems. One of the early findings is a papulopustular rash, which has a wide differential diagnosis. Method: The authors report the case of a male newborn diagnosed with HIES. He presented with papulopustular dermatitis on the scalp. The authors also present a review of current theory on the pathophysiology, clinical presentation, and management of HIES. Conclusion: Although HIES is a multisystem disorder, many of the manifestations... περισσότερα »
Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome in Pregnancy
First Presentation of Background: Reed's syndrome, also known as hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome, is an autosomal dominant condition in which affected individuals may develop cutaneous leiomyomas, uterine fibroids, and renal cell carcinoma. Objective: This report describes a unique case of HLRCC because it presented in pregnancy with development of cutaneous pilar leiomyomas. Methods: Review of the literature for previous cases of Reed's syndrome during pregnancy including PubMed and Medline search. Results: Genetic testing of this patient demo... περισσότερα »
Radiation-Induced Breast Angiosarcoma
Case Report and Clinical Approach: Importance: Radiation-induced angiosarcoma after conservative treatment of breast cancer affects a small percentage of patients but has a significant impact on survival. Early detection requires a high index of suspicion and is important for optimal management of this aggressive disease. Observations: The patient reported here presented with radiation-induced angiosarcoma of the left breast 14 years after radiation therapy. Histopathology was positive for anti-CD31, anti-CD34, D2-40, and anti–factor VIII (von Willebrand). She underwent a total mas... περισσότερα »
Generalized Recalcitrant Pruritus as the Presenting Manifestation of Hypereosinophilic Syndrome
Generalized Recalcitrant Pruritus as the Presenting Manifestation of Hypereosinophilic Syndrome: Background and Objective: Pruritus is a frequent occurrence in dermatology, and investigation is often unrevealing. The authors report the case of a 65-year-old man presenting with generalized recalcitrant pruritus as the presenting manifestation of hypereosinophilic syndrome. Methods and Results: A 65-year-old man developed intractable pruritus. Results of polymerase chain reaction clonal rearrangement were positive and led to the diagnosis and treatment. The patient also developed mas... περισσότερα »
Chronic Spontaneous Urticaria (CSU)
Canadian Dermatologists Perspective: Background: Chronic spontaneous urticaria (CSU) is a skin disorder that is said to be "frustrating" and "difficult to treat." It is characterized by recurrent hives for more than 6 weeks, and is further divided into spontaneous or inducible by physical stimuli.1 To better understand dermatologists' perspective of this disorder, a survey was conducted with Canadian dermatologists. Methods: A detailed online practice survey was sent to all currently practicing Canadian dermatologists. Results: In all, 80 responses were received (response rate o... περισσότερα »
Cutaneous Strongyloides Infection Postchemotherapy
Cutaneous Strongyloides Infection Postchemotherapy: Background and Objective: While clinical symptoms of strongyloidiasis are often nonspecific, larva currens (with erythematous, serpiginous, and pruritic papules and plaques) should prompt investigation including stool microscopy, serology, and skin biopsy of the lesion. Appropriate diagnosis and treatment with ivermectin is necessary, especially in the immunocompromised patient who is at increased risk for hyperinfection syndrome and disseminated disease. Conclusion: We present a 61-year-old immunocompromised man with presentation... περισσότερα »
A rosacea-specific screening instrument (Rosascreen), consisting of a subject-completed questionnaire and screening algorithm, was developed based on current diagnostic criteria for rosacea.
Development and Evaluation of a Rosacea Screening Instrument (Rosascreen): Background: There are no current instruments to facilitate population screening for rosacea. Objective: To develop and evaluate a screening instrument for rosacea applicable for population surveys. Methods: A rosacea-specific screening instrument (Rosascreen), consisting of a subject-completed questionnaire and screening algorithm, was developed based on current diagnostic criteria for rosacea. Three iterations were pilot tested and refined for clarity and sensitivity in adult outpatients with and without... περισσότερα »
Rationale and Argument for Subunit Mohs Excision in Nasal Reconstruction
Rationale and Argument for Subunit Mohs Excision in Nasal Reconstruction: Background: Optimal aesthetic results are achieved when nasal defects after Mohs micrographic surgery (MMS) are reconstructed as entire nasal subunits. Objective: To illustrate the importance of reconstructing the nose in entire subunits and explore the possibilities of expanding the principles of subunit reconstruction to the concept of subunit Mohs excision. Methods: An 83-year-old man presented for MMS to excise 3 lesions on the nasal ala. The surgeons elected to excise and reconstruct the entire subunit.... περισσότερα »
Contact Dermatitis to Personal Sporting Equipment in Youth
Contact Dermatitis to Personal Sporting Equipment in Youth: Background: Contact dermatitis to personal sporting equipment in youth is poorly studied. Objective: To review the results of patch testing 6 youth to their sporting equipment in a dermatology general private practice from 2006 to 2011. Methods: A retrospective analysis of 6 youth aged 11 to 14 who were evaluated for chronic and persistent dermatitis occurring in relation to sports equipment was conducted. All patients were subjected to epicutaneous (patch) testing, which included some or all of the following: North Ameri... περισσότερα »
Tms Therapy For Tinnitus
Tms Therapy For Tinnitus: An Overview Of Tinnitus Tinnitus is a debilitating condition that affects around 45 million people in America. It causes a person to experience a chronic buzzing sensation in the ear. Tinnitus can sometimes be a sign of an underlying health condition, such as a circulatory problem or hearing loss. In many cases, the exact cause of tinnitus cannot be identified. Anyone can develop tinnitus. However, there are some people who are at a greater risk for it than others. People who work around loud noises are more likely to develop this condition. Tinnitus is al... περισσότερα »
Composite Vascular Pedicled Middle Turbinate Flap for Reconstruction of Sellar Defects
Composite Vascular Pedicled Middle Turbinate Flap for Reconstruction of Sellar Defects: Objectives: Herein, we describe our experience in simple harvest of the vascular pedicled middle turbinate flap (MTF) sufficient for sellar defect reconstruction. Methods: An anatomical feasibility study is done in 10 sides of 5 preserved injected cadaveric heads. The middle turbinate is separated from the skull base and the basal lamella with or without retrograde dissection of its tail as a composite flap based on the middle turbinate and posterolateral nasal arteries. The technique was appli... περισσότερα »
The role of septoplasty in the management of nasal septum fracture
a randomized quality of life study: Fracture of the nasal septum is a common injury. Fracture reduction using Ash forceps is the standard treatment for non-severely comminuted cases. In this study, septoplasty was compared to Ash forceps reduction of nasal septum fractures with regard to the quality of life outcome of patient breathing. Thirty consecutive patients with non-comminuted septal fractures were divided randomly into two groups. In group I, fractures were managed by closed reduction (using Ash forceps), while in group II, fractures were managed by septoplasty surgery. ... περισσότερα »
Possible interaction between tobacco use and EBV in oral squamous cell carcinoma
Possible interaction between tobacco use and EBV in oral squamous cell carcinoma: [image: gr1.sml] Epstein–Barr virus (EBV), a gamma-1 herpesvirus, has tropism for B lymphocytes and epithelial cells of the upper aerodigestive tract. Despite most adults being asymptomatic carriers of an EBV infection obtained during adolescence, in some individuals EBV is oncogenic: it drives several types of lymphoma and some epithelial malignancies, principally nasopharyngeal carcinoma (NPC) [1]. EBV latent membrane protein 1 (LMP1), an active transmembrane receptor, appears to mediate malignant t... περισσότερα »
Precautionary Allergy Labelling
NO MORE TRACES!: Abstract Dietary avoidance of allergens is crucial in the management of food allergy. Food allergic individuals (and those who prepare their food) rely on the disclosure of allergens as ingredients. Under the EU Food Information for Consumers (EC Regulation No. 1169/2011), food producers are required to disclose the presence of any of 14 allergens as ingredients, whether pre-packed or not (e.g. from restaurants and other catering outlets). However, legislation does not extend to the possibility of food allergens present from cross-contamination or cross-contact in... περισσότερα »
Evaluation of the measurement properties of symptom measurement instruments for atopic eczema
: a systematic review: [image: cover.gif?v=1&s=6c0d652859090820dec2cb4e] Abstract Background Symptoms have been identified as a core outcome domain for atopic eczema (AE) trials. Various instruments exist to measure symptoms in AE, but they vary in quality and there is a lack of standardization between clinical trials. Our objective was to systematically evaluate the quality of the evidence on the measurement properties of AE symptom instruments, thereby informing consensus discussions within the Harmonising Outcome Measures for Eczema (HOME) initiative regarding the most appr... περισσότερα »
Oncological Safety of Submental Artery Island Flap in Oral Reconstruction - Analysis of 229 Cases
Oncological Safety of Submental Artery Island Flap in Oral Reconstruction - Analysis of 229 Cases: Abstract Submental artery island flap (SMIF) is gaining popularity as a viable alternative to free flaps in carefully selected oral cavity defects after surgical extirpation of cancers.The current paper looks into the overall efficacy and oncological safety of the flap based on a prospective audit of 229 cases done at a high volume cancer center from october 2004 to september 2012 and concludes that SMIF is a oncologically safe,reliable reconstructive option in carefully selected oral ... περισσότερα »
NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
Publication date: Available online 19 July 2016 Source:Free Radical Biology and Medicine Author(s): Elyse Di Marco, Stephen P. Gray, Kit Kennedy, Cedric Szyndralewiez, Alicia N. Lyle, Bernard Lassègue, Kathy K. Griendling, Mark E. Cooper, Harald H.H.W. Schmidt, Karin A.M. Jandeleit-Dahm Smooth muscle cell (SMC) proliferation and fibrosis contribute to the development of advanced atherosclerotic lesions. […]
Molecular basis of reactive oxygen species-induced inactivation of α4β2 nicotinic acetylcholine receptors
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 22 δευτερόλεπτα
Publication date: Available online 18 July 2016 Source:Free Radical Biology and Medicine Author(s): Junjun Zhao, Yan Zheng, Fenqin Xue, Yongchang Chang, Hui Yang, Jianliang Zhang The α4β2 neuronal nicotinic acetylcholine receptors (nAChRs) are the most widespread heteromeric nAChR subtype in the brain, mediating fast synaptic transmission. Previous studies showed that α4β2 nAChRs could be inactivated […]
Tumor heterogeneity measured on F-18 fluorodeoxyglucose positron emission tomography/computed tomography combined with plasma Epstein-Barr Virus load predicts prognosis in patients with primary nasopharyngeal carcinoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Objectives/Hypothesis Plasma Epstein-Barr virus (EBV) DNA concentrations predict prognosis in patients with nasopharyngeal carcinoma (NPC). Recent evidence also indicates that intratumor heterogeneity on F-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) scans is predictive of treatment outcomes in different solid malignancies. Here, we sought to investigate the prognostic value of heterogeneity parameters in patients with primary […]
Office-based 532-Nanometer pulsed potassium-titanyl-phosphate laser for marsupialization of laryngeal and vallecular mucoceles
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Objectives/Hypothesis Many laryngopharyngeal disorders are effectively managed in the office. Herein, an in-office method utilizing the 532-nm potassium-titanyl-phosphate (KTP) laser for the treatment of benign laryngeal and vallecular mucoceles is described. Study Design Retrospective case review. Methods A review was performed of patients who had their vallecular or laryngeal mucoceles marsupialized in the office using […]
Soft-Tissue Deformities in Craniofacial Neurofibromatosis Type 1
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Comprehensive and Global Approach of Soft-Tissue Deformities in Craniofacial Neurofibromatosis Type 1: Background: To present a single-institution experience in the comprehensive and global soft-tissue surgical approach of patients with craniofacial neurofibromatosis type 1 (NF-1). Methods: A retrospective analysis of patients with craniofacial NF-1 (n = 20) who underwent craniofacial soft-tissue reconstruction between 1993 and 2014 […]
The Effect of Coenzyme Q10 (Ubiquinone) on Random Pattern Skin Flap Survival
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
in Rat Model: Background: In this study, the effect of coenzyme Q10 (CQ10) on flap survival was investigated. Methods: Fifty Wistar Albino rats were divided into 5 groups. The survival rates of the skin flaps were assessed 10 days after complete elevation of the flaps. Regions of survival and necrosis were drawn on transparent […]
Strategies for the Optimal Individualized Surgical Management of Craniofacial Fibrous Dysplasia
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Strategies for the Optimal Individualized Surgical Management of Craniofacial Fibrous Dysplasia: Background: The surgical management of craniofacial fibrous dysplasia is controversial. The purpose of this study was to report the surgical outcomes of individualized management of craniofacial fibrous dysplasia of a single institution. Methods: Data from patients (n = 20) with craniofacial fibrous dysplasia, who […]
Chlorogenic Acid Enhances Abdominal Skin Flap Survival Based on Epigastric Artery in Nondiabetic and Diabetic Rats
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Chlorogenic Acid Enhances Abdominal Skin Flap Survival Based on Epigastric Artery in Nondiabetic and Diabetic Rats: Abstract: Previous studies showed that chlorogenic acid (CGA) accelerates wound healing via its antioxidant activity. We aimed to investigate the effect of CGA in an experimental epigastric abdominal skin flap model in nondiabetic and diabetic rats. Rats were firstly […]
Surgical Treatment and Recurrence of Cutaneous Nasal Malignancies
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
A 26-Year Retrospective Review of 1795 Patients: Abstract: Frequent localization of facial malignancies in the nasal area and their required complete surgical extirpation pose a significant challenge to the plastic surgeon, who is called to perform a suitable delicate reconstruction of produced nasal skin defects. The present study was aimed to examine the role of […]
Acellular Dermal Matrix
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
A Meta-analysis of Outcomes Using Acellular Dermal Matrix in Breast and Abdominal Wall Reconstructions: Event Rates and Risk Factors Predictive of Complications: Background: The use of acellular dermal matrix (ADM) has gained acceptance in breast and abdominal wall reconstructions. Despite its extensive use, there is currently a wide variation of reported outcomes in the literature. […]
Three-Dimensional Reconstruction and Color Duplex Ultrasound
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Preoperative Imaging for Thoracic Branch of Supraclavicular Artery Flap: A Comparative Study of Contrast-Enhanced Ultrasound With Three-Dimensional Reconstruction and Color Duplex Ultrasound: Objective: The thoracic branch of supraclavicular artery (TBSA) flap has been widely used to reconstruct face and neck defects. However, the branches of the supraclavicular artery (SCA) exhibit considerable anatomical variations. The aim […]
Preoperative Imaging for Thoracic Branch of Supraclavicular Artery Flap
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
A Comparative Study of Contrast-Enhanced Ultrasound With Three-Dimensional Reconstruction and Color Duplex Ultrasound: Objective: The thoracic branch of supraclavicular artery (TBSA) flap has been widely used to reconstruct face and neck defects. However, the branches of the supraclavicular artery (SCA) exhibit considerable anatomical variations. The aim of this study was to evaluate and compare the […]
Potential of Inducible Nitric Oxide Synthase as a Therapeutic Target for Allergen-Induced Airway Hyperresponsiveness: A Critical Connection to Nitric Oxide Levels and PARP Activity
Although expression of inducible NO synthase (iNOS) in the lungs of asthmatics and associated nitrosative damage are established, iNOS failed as a therapeutic target for blocking airway hyperresponsiveness (AHR) and inflammation in asthmatics. This dichotomy calls for better strategies with which the enzyme is adequately targeted. Here, we confirm iNOS expression in the asthmatic lung with concomitant protein nitration and poly(ADP-ribose) polymerase (PARP) activation. We show, for the first time, that iNOS is highly expressed in peripheral blood mononuclear cells (PBMCs) of asthm... περισσότερα »
Single-institution experience and learning curve with upper airway stimulation
As upper airway stimulation (UAS) surgical implantation is a new procedure, the authors thought it would be instructive to describe a single-institution’s experience with the inception of a UAS program. The description of our experience at the University of Pennsylvania may be useful for planning purposes when surgeons and sleep medicine physicians are considering program… Continue reading Single-institution experience and learning curve with upper airway stimulation
Tumor heterogeneity measured on F-18 fluorodeoxyglucose positron emission tomography/computed tomography combined with plasma Epstein-Barr Virus load predicts prognosis in patients with primary nasopharyngeal carcinoma
Objectives/Hypothesis Plasma Epstein-Barr virus (EBV) DNA concentrations predict prognosis in patients with nasopharyngeal carcinoma (NPC). Recent evidence also indicates that intratumor heterogeneity on F-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) scans is predictive of treatment outcomes in different solid malignancies. Here, we sought to investigate the prognostic value of heterogeneity parameters in patients with primary… Continue reading Tumor heterogeneity measured on F-18 fluorodeoxyglucose positron emission tomography/computed tomography combined with p... περισσότερα »
Office-based 532-Nanometer pulsed potassium-titanyl-phosphate laser for marsupialization of laryngeal and vallecular mucoceles
Objectives/Hypothesis Many laryngopharyngeal disorders are effectively managed in the office. Herein, an in-office method utilizing the 532-nm potassium-titanyl-phosphate (KTP) laser for the treatment of benign laryngeal and vallecular mucoceles is described. Study Design Retrospective case review. Methods A review was performed of patients who had their vallecular or laryngeal mucoceles marsupialized in the office using… Continue reading Office-based 532-Nanometer pulsed potassium-titanyl-phosphate laser for marsupialization of laryngeal and vallecular mucoceles
Language deterioration in bilingual Alzheimer’s disease patients: A longitudinal study
Publication date: Available online 9 July 2016 Source:Journal of Neurolinguistics Author(s): Marco Calabria, Gabriele Cattaneo, Paula Marne, Mireia Hernández, Montserrat Juncadella, Jordi Gascón-Bayarri, Isabel Sala, Alberto Lleó, Jordi Ortiz-Gil, Lidia Ugas, Rafael Blesa, Ramón Reñé, Albert Costa In the context of bilingual research, little is known about the effects of neurodegenerative disorders (NDs) on the… Continue reading Language deterioration in bilingual Alzheimer’s disease patients: A longitudinal study
Tracking sentence comprehension: Test-retest reliability in people with aphasia and unimpaired adults
Conclusion Results indicated moderate-to-low reliability for unimpaired listeners; however, reliable eye movement patterns were detected for processes specific to passive sentences (e.g., thematic reanalysis). In contrast, individuals with aphasia exhibited strong and stable performance across sentence types in response measures and online eye movements. These findings indicate that visual-world eyetracking provides a reliable measure of… Continue reading Tracking sentence comprehension: Test-retest reliability in people with aphasia and unimpaired adults
Individual differences in the bilingual brain: The role of language background and DRD2 genotype in verbal and non-verbal cognitive control
Publication date: November 2016 Source:Journal of Neurolinguistics, Volume 40 Author(s): Kelly A. Vaughn, Aurora I. Ramos Nuñez, Maya R. Greene, Brandin A. Munson, Elena L. Grigorenko, Arturo E. Hernandez Bilingual language control may involve cognitive control, including inhibition and switching. These types of control have been previously associated with neural activity in the inferior frontal… Continue reading Individual differences in the bilingual brain: The role of language background and DRD2 genotype in verbal and non-verbal cognitive control
The evolution of language: Sharing our mental lives
Publication date: Available online 24 June 2016 Source:Journal of Neurolinguistics Author(s): Michael C. Corballis There are two broad views on the evolution of language. One is that language involved a restructuring of thought, unique to humans, which occurred within the past 100,000 years. The other view, sketched in this article, is that human thought evolved… Continue reading The evolution of language: Sharing our mental lives
On the parallel evolution of syntax and lexicon: A Merge-only view
Publication date: Available online 21 June 2016 Source:Journal of Neurolinguistics Author(s): Koji Fujita It is a generally accepted view that syntax and the lexicon are two separate modules of human language and therefore that their evolution must be studied independently of each other. In this brief article I challenge this traditional view and argue, in… Continue reading On the parallel evolution of syntax and lexicon: A Merge-only view
Direction matters: Event-related brain potentials reflect extra processing costs in switching from the dominant to the less dominant language
Publication date: November 2016 Source:Journal of Neurolinguistics, Volume 40 Author(s): Chia-Hsuan Liao, Shiao-Hui Chan Language switching is common in bilingual processing, and it has been repeatedly shown to induce processing costs. However, only a handful of studies have examined such costs at the sentence level, with a limited few among them having incorporated factors extensively… Continue reading Direction matters: Event-related brain potentials reflect extra processing costs in switching from the dominant to the less dominant language
The bicycle problem that nearly broke mathematics
Jim Papadopoulos has spent a lifetime pondering the maths of bikes in motion. Now his work has found fresh momentum. Nature 535 338 doi: 10.1038/535338a from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/2aaovtg via IFTTT
Novel technique of robotic extralevator abdominoperineal resection with gracilis flap closure
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Abstract Background The purpose of this paper is to introduce a robotic assisted approach to extralevator abdominoperineal excision in the modified Lloyd-Davis position with reconstruction of the perineum using pedicled gracilis flaps, and to discuss outcomes in a cohort of six patients. Methods Data was collected by chart review on six patients who underwent extralevator excision with gracilis flap reconstruction from 10/2013 to 06/2015. Technical details, operative data, oncologic outcomes, and wound healing complications were evaluated. Results There were no instances of int... περισσότερα »
Influence of different post-interventional maintenance concepts on periodontal outcomes: an evaluation of three systematic reviews
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Abstract Background To selectively review the existing literature on post-interventional maintenance protocols in patients with periodontal disease receiving either non-surgical or surgical periodontal treatment. Methods Three systematic reviews with different periodontal interventions, i.e. scaling and root planing (SRP), SRP with adjunctive antibiotics or regenerative periodontal surgery were evaluated focusing on their post-interventional maintenance care. Due to the early publication of one review an additional literature search update was undertaken. The search was executed ... περισσότερα »
The future of pediatric dentistry education and curricula: a Chilean perspective
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Abstract Background A meeting was organised to consolidate a network of researchers and academics from Australia, Brazil, Chile, the UK and the USA, relating to Early Childhood Caries (ECC) and Dental Trauma (DT). As part of this meeting, a dedicated session was held on the future of paediatric dental education and curricula. Twenty-four paediatric dentistry (PD) academics, representing eight Chilean dental schools, and three international specialists (from Brazil and Latvia) participated in group discussions facilitated by five members of the ECC/DT International Collaborative Ne... περισσότερα »
Molecular characterization of glycation-associated skin ageing: An alternative skin model to study topical anti-glycation activity in vitro of a cosmeceutical and pharmaceutical formulation
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Molecular characterization of glycation-associated skin ageing: An alternative skin model to study topical anti-glycation activity in vitro of a cosmeceutical and pharmaceutical formulation: Summary Background Glycation is a non-enzymatic reaction that cross-links a sugar molecule and protein macromolecule to form advanced glycated products (AGEs) that are associated with various age-related disorders; therefore glycation plays an important role in skin chronological ageing. Objectives This study aims to develop a novel skin glycation model *in vitro* as the screening tool for topic... περισσότερα »
Cross-reactivity between methylisothiazolinone, octylisothiazolinone and benzisothiazolinone using a modified local lymph node assay
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Cross-reactivity between methylisothiazolinone, octylisothiazolinone and benzisothiazolinone using a modified local lymph node assay: Abstract Background In the light of the exceptionally high rates of contact allergy to the preservative methylisothiazolinone (MI), information about cross-reactivity between MI, octylisothiazolinone (OIT) and benzisothiazolinone (BIT) is needed. Objectives To study cross-reactivity between MI and OIT, and, MI and BIT. Methods Immune responses to MI, OIT and BIT were studied in vehicle and MI-sensitised female CBA mice by a modified local lymph node as... περισσότερα »
Complement in bullous pemphigoid: results from a large observational study
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Complement in bullous pemphigoid: results from a large observational study: Abstract Bullous pemphigoid (BP) is a subepidermal autoimmune blistering disease characterized by auto-antibodies directed against the hemidesmosomal proteins 180-kDa bullous pemphigoid antigen 2 (BP180, BPAG2) and/or 230-kDa bullous pemphigoid antigen 1 (BP230, BPAG1).1 It is thought that complement activation plays an important role in the pathogenesis of BP.1 However, the role of complement in the formation of subepidermal blisters has been disputed and complement independent mechanisms of blister formati... περισσότερα »
Patients with chronic cold urticaria may benefit from doxycycline therapy
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Patients with chronic cold urticaria may benefit from doxycycline therapy: Abstract Chronic cold urticaria (ColdU) is a rare but severe and potentially life-threatening form of chronic urticaria characterized by the development of wheal and flare type skin reactions or angioedema after skin exposure to cold1. Extensive cold contact (e.g. swimming in cold water) and low trigger thresholds (i.e. wheal responses to temperatures of 20°C or higher) may lead to systemic reactions including anaphylactic shock2. This article is protected by copyright. All rights reserved.
Ketone Bodies and Exercise Performance: The Next Magic Bullet or Merely Hype?
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 51 δευτερόλεπτα
Abstract Elite athletes and coaches are in a constant search for training methods and nutritional strategies to support training and recovery efforts that may ultimately maximize athletes' performance. Recently, there has been a re-emerging interest in the role of ketone bodies in exercise metabolism, with considerable media speculation about ketone body supplements being routinely used by professional cyclists. Ketone bodies can serve as an important energy substrate under certain conditions, such as starvation, and can modulate carbohydrate and lipid metabolism. Dietary strategie... περισσότερα »
Different Sports, But the Same Physical and Physiological Profiles?
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 51 δευτερόλεπτα
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Metaboreflex activation delays heart rate recovery after aerobic exercise in never-treated hypertensive men
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 51 δευτερόλεπτα
Abstract Muscle metaboreflex influences heart rate (HR) regulation after aerobic exercise. Therefore, increased metaboreflex sensitivity may help to explain the delayed HR recovery (HRR) reported in hypertension. This study assessed and compared the effect of metaboreflex activation after exercise on HRR, cardiac baroreflex sensitivity (cBRS) and heart rate variability (HRV) in normotensive (NT) and hypertensive (HT) men. Twenty-three never-treated HT and 25 NT men randomly underwent two-cycle ergometer exercise sessions (30min, 70%VO2peak) followed by 5 min of inactive recovery pe... περισσότερα »
Utility of S100B Serum Level for the Determination of Concussion in Male Rugby Players
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 51 δευτερόλεπτα
Abstract Background The incidence of concussion in professional direct-contact sports, particularly in rugby, has increased in recent years. To date, cognitive assessment is the most common means of determining whether a concussed player can return to the game. Serum S100B assay, an objective blood test known to be useful in brain injury management, may offer a novel additional approach to the management of concussed male rugby players. Objective The aim of this study was to investigate the S100B utility for the determination of concussion in a professional 15-players-a-side rugby... περισσότερα »
Effects of selective carotid body stimulation with adenosine in conscious humans
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 51 δευτερόλεπτα
Abstract Stimulation of peripheral chemoreceptors by acute hypoxia causes an increase in minute ventilation (VI), heart rate (HR) and arterial blood pressure (BP). However, the contribution of particular chemosensory areas - carotid (CB) *vs*. aortic bodies - to this response in humans remains unknown. We performed a blinded, randomized and placebo controlled study in 11 conscious patients (9 men, 2 women) undergoing common carotid artery angiography. Doses of adenosine ranging from 4 to 512 μg or placebo solution of matching volume were administered in randomized order via a diag... περισσότερα »
Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 51 δευτερόλεπτα
Key point - Exercise increases skeletal muscle energy turnover and one of the important substrates for the working muscle is glucose taken up from the blood. - The GTPase Rac1 can be activated by muscle contraction and has been found to be necessary for insulin-stimulated glucose uptake, although its role in exercise-stimulated glucose uptake is unknown. - We show that Rac1 regulates the translocation of the glucose transporter GLUT4 to the plasma membrane in skeletal muscle during exercise. - We find that Rac1 knockout mice display significantly reduce... περισσότερα »
Low Energy Availability in Exercising Women: Historical Perspectives and Future Directions
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 51 δευτερόλεπτα
Abstract Research on the health of female athletes has developed substantially over the past 50 years. This review aims to provide an overview of this research and identify directions for future work. While early cross-sectional studies focused primarily on menstruation, research has progressed to now encompass hormonal changes, bone health and lipid profiles. The seminal work of Loucks and colleagues distinguished that these health concerns were due to low energy availability (LEA) rather than exercise alone. LEA occurs when the body has insufficient energy available to meet the n... περισσότερα »
Atopic Predilection among Kawasaki Disease Patients: A Cross-Sectional Study of 1,187,757 Teenagers
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Background: Kawasaki disease (KD) is an acute, systemic vasculitis in children, with an etiology that is not completely understood. It is assumed that the development of KD is mediated by an immunologic response. Several reports from East Asia have found a higher prevalence of atopic diseases among patients with KD, but a large-scale study of […]
Very low-dose isotretinoin in mild to moderate papulopustular rosacea; a retrospective review of 52 patients
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Abstract Background/Objectives Rosacea is a chronic inflammatory disorder that affects up to 10% of the population. Standard treatments include topical azelaic acid and metronidazole or systemic tetracyclines. Isotretinoin has generally been restricted to severe disease, often at a dose of 0.5–1.0 mg/kg/day. Method Retrospective review of open-label isotretinoin (initial dose 20 mg/day, with dose adjustments […]
Monitoring recommendations for oral azathioprine, methotrexate and cyclosporin in a paediatric dermatology clinic and literature review
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Abstract Background/Objectives Systemic oral immunomodulators azathioprine, methotrexate and cyclosporin are widely used in paediatric dermatology. Routine blood tests are performed to minimise drug-related adverse events. However, the frequency of monitoring tests may lead to significant fearful experiences for patients. We reviewed haematological abnormalities and clinical side-effects in a paediatric clinic population commencing immunomodulators for dermatological […]
Comprehensive Mutation Analysis of PMS2 in a Large Cohort of Probands Suspected of Lynch Syndrome or Constitutional Mismatch Repair Deficiency (CMMRD) Syndrome
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
ABSTRACT Monoallelic PMS2 germline mutations cause 5–15% of Lynch syndrome, a midlife cancer predisposition, whereas biallelic PMS2 mutations cause approximately 60% of constitutional MMR deficiency (CMMRD), a rare childhood cancer syndrome. Recently improved DNA and RNA-based strategies are applied to overcome problematic PMS2 mutation analysis due to the presence of pseudogenes and frequent gene conversion […]
JDB, Vol. 4, Pages 23: Regulation of Hedgehog Signalling Inside and Outside the Cell
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
The hedgehog (Hh) signalling pathway is conserved throughout metazoans and plays an important regulatory role in both embryonic development and adult homeostasis. Many levels of regulation exist that control the release, reception, and interpretation of the hedgehog signal. The fatty nature of the Shh ligand means that it tends to associate tightly with the cell […]
An Uncommon Case of Adolescent Ovarian Teratoma Incarcerated in Inguinal Hernia
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Mature cystic teratoma is the most frequent benign ovarian neoplastic lesion in adolescents and is generally composed of fully differentiated tissue arising from multipotential three germinal layers. It accounts for approximately 50% of benign ovarian tumors in childhood. Rarely, a bilateral, synchronous, or metachronous presentation can be observed, supporting a conservative approach as the first […]
Mechanism Underlying Bonding Water Film Effect on Rheological Parameters
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
From experiments on bonding water of different slurries and the analysis of flow curves, the bilinear fluid model has been improved. The results showed that the rheological parameters correspond to physical processes at different stages of shear strain. As shear rate increases, slurries evolve from high-viscosity Bingham fluids to low-viscosity Bingham fluids. Specific surface area […]
Cord Blood Adiponectin and Visfatin Concentrations in relation to Oxidative Stress Markers in Neonates Exposed and Nonexposed In Utero to Tobacco Smoke
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Aims. Maternal smoking is considered as a source of oxidative stress, which has been implicated to disrupted adipokines expression in adipose tissue. We examined the relationship between selected adipokines and markers of oxidative stress/antioxidant defence in the umbilical cord of neonates exposed and nonexposed in utero to tobacco smoke. Methods. Subjects including 85 healthy neonates […]
Cancers, Vol. 8, Pages 70: TCF/LEF Transcription Factors: An Update from the Internet Resources
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) proteins (TCFs) from the High Mobility Group (HMG) box family act as the main downstream effectors of the Wnt signaling pathway. The mammalian TCF/LEF family comprises four nuclear factors designated TCF7, LEF1, TCF7L1, and TCF7L2 (also known as TCF1, LEF1, TCF3, and TCF4, respectively). The proteins display common structural features […]
Lies, Damned Lies and Statistics: SPYing on trial design by Bishal Gyawali
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
independent ecancer blogger Dr Bishal Gyawali rounds up the latest news in clinical trial design. The New England Journal of Medicine is currently swamped with papers on adaptive design of clinical trials, with recent papers including two clinical… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29MQRVG via IFTTT
Precautionary Allergy Labelling
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
NO MORE TRACES!: Abstract Dietary avoidance of allergens is crucial in the management of food allergy. Food allergic individuals (and those who prepare their food) rely on the disclosure of allergens as ingredients. Under the EU Food Information for Consumers (EC Regulation No. 1169/2011), food producers are required to disclose the presence of any of […]
Evaluation of the measurement properties of symptom measurement instruments for atopic eczema
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
: a systematic review: Abstract Background Symptoms have been identified as a core outcome domain for atopic eczema (AE) trials. Various instruments exist to measure symptoms in AE, but they vary in quality and there is a lack of standardization between clinical trials. Our objective was to systematically evaluate the quality of the evidence on […]
Oncological Safety of Submental Artery Island Flap in Oral Reconstruction – Analysis of 229 Cases
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Oncological Safety of Submental Artery Island Flap in Oral Reconstruction – Analysis of 229 Cases: Abstract Submental artery island flap (SMIF) is gaining popularity as a viable alternative to free flaps in carefully selected oral cavity defects after surgical extirpation of cancers.The current paper looks into the overall efficacy and oncological safety of the flap […]
How effective is the Invisalign® system in expansion movement with Ex30′ aligners?
AbstractObjectives The aims of this study are to validate a new method for quantifying the predictability of expansion movement with the Invisalign® system and to determine whether there are statistically significant differences between planned expansion with ClinCheck® and actual clinical quantification using upper post-treatment model comparisons. Materials and methods A sample of 116 patients subjected to expansion with Invisalign® was studied. The following variables were measured at T1 and T2 on 3D models and ClinCheck®: canine gingival width, first premolar gingival width, se... περισσότερα »
Contact mechanics of highly porous oxide nanoparticle agglomerates
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Efficient nanopowder processing requires knowledge of the powder’s mechanical properties. Due to the large surface area to volume ratio, nanoparticles experience relatively strong attractive interactions, leading to the formation of micron-size porous structures called agglomerates. Significant effort has been directed towards the development of models and experimental procedures to estimate the elasticity of porous […]
The pH heterogeneity in human calf muscle during neuromuscular electrical stimulation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Purpose The aim of the study was to examine pH heterogeneity during fatigue induced by neuromuscular electrical stimulation (NMES) using phosphorus magnetic resonance spectroscopy (31P-MRS). It is hypothesized that three pH components would occur in the 31P-MRS during fatigue, representing three fiber types. Methods The medial gastrocnemius of eight subjects was stimulated within a 3-Tesla […]
Fast measurement of blood T1 in the human carotid artery at 3T: Accuracy, precision, and reproducibility
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Purpose To develop a fast protocol for measuring T1 values in the internal carotid artery (ICA), to validate this technique with in vitro measurements, and to evaluate its reproducibility. Methods A modified Look–Locker sequence was optimized to enable rapid determination of T1 in the ICA at 3T. T1 values from the ICA were compared with […]
Cancers, Vol. 8, Pages 70: TCF/LEF Transcription Factors: An Update from the Internet Resources
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) proteins (TCFs) from the High Mobility Group (HMG) box family act as the main downstream effectors of the Wnt signaling pathway. The mammalian TCF/LEF family comprises four nuclear factors designated TCF7, LEF1, TCF7L1, and TCF7L2 (also known as TCF1, LEF1, TCF3, and TCF4, respectively). The proteins display common structural features […]
In silico analysis of enantioselective binding of immunomodulatory imide drugs to cereblon
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Thalidomide and its analogs, lenalidomide and pomalidomide (referred to as immunomodulatory imide drugs or IMiDs) have been known to treat multiple myeloma and other hematologic malignancies as well as to caus… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/2abrXjV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Depiction of dentatorubrothalamic tract fibers in patients with Parkinson’s disease and multiple sclerosis in deep brain stimulation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background We wanted to depict fibers of the dentatorubrothalamic tract in patients with Parkinson’s disease and multiple sclerosis in order to use this knowledge for clinical routine and to show its relation to the corticospinal tract for deep brain stimulation. Fibers of these white matter tracts were depicted between February 2014 and February 2015 […]
Secondary consent to biospecimen use in a prostate cancer biorepository
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Biorepository research has substantial societal benefits. This is one of the few studies to focus on male willingness to allow future research use of biospecimens. Methods This study analyzed the future research consent questions from a prostate cancer biorepository study (N = 1931). The consent form asked two questions regarding use of samples […]
Knowledge of women in family planning and future desire to use contraception: a cross sectional survey in Urban Cameroon
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background The rate of modern contraceptive use will be on an increase and maternal mortality on a decrease if women had a good knowledge on family planning and its methods. This survey was designed to evaluate the knowledge and determine the future desires to use contraception among women in Urban Cameroon. Methods We conducted […]
Immune checkpoint inhibitors and response analysis: a tough challenge. A case report
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Treatment of metastatic NSCLC patients with immune-checkpoint medicine is intriguing for the potential efficacy; however it may be difficult to evaluate the clinical response due to the lack of reliable immune-monitoring markers up to now and the possibility of radiological pseudo-progression. Case presentation Herein we report the case of a patient ex-smoker with […]
The association between caregiver well-being and care provided to persons with Alzheimer’s disease and related disorders
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Alzheimer’s disease and related disorders (ADRD) are some of the leading causes of morbidity in developed nations. Unpaid family caregivers are primarily responsible for providing the care and support needed by persons with ADRD. In the process of caring for their loved ones with ADRD, caregivers often have to deal with multiple challenges, […]
Mechanism Underlying Bonding Water Film Effect on Rheological Parameters
From experiments on bonding water of different slurries and the analysis of flow curves, the bilinear fluid model has been improved. The results showed that the rheological parameters correspond to physical processes at different stages of shear strain. As shear rate increases, slurries evolve from high-viscosity Bingham fluids to low-viscosity Bingham fluids. Specific surface area… Continue reading Mechanism Underlying Bonding Water Film Effect on Rheological Parameters
An Uncommon Case of Adolescent Ovarian Teratoma Incarcerated in Inguinal Hernia
Mature cystic teratoma is the most frequent benign ovarian neoplastic lesion in adolescents and is generally composed of fully differentiated tissue arising from multipotential three germinal layers. It accounts for approximately 50% of benign ovarian tumors in childhood. Rarely, a bilateral, synchronous, or metachronous presentation can be observed, supporting a conservative approach as the first… Continue reading An Uncommon Case of Adolescent Ovarian Teratoma Incarcerated in Inguinal Hernia
Cord Blood Adiponectin and Visfatin Concentrations in relation to Oxidative Stress Markers in Neonates Exposed and Nonexposed In Utero to Tobacco Smoke
Aims. Maternal smoking is considered as a source of oxidative stress, which has been implicated to disrupted adipokines expression in adipose tissue. We examined the relationship between selected adipokines and markers of oxidative stress/antioxidant defence in the umbilical cord of neonates exposed and nonexposed in utero to tobacco smoke. Methods. Subjects including 85 healthy neonates… Continue reading Cord Blood Adiponectin and Visfatin Concentrations in relation to Oxidative Stress Markers in Neonates Exposed and Nonexposed In Utero to Tobacco Smoke
Depiction of dentatorubrothalamic tract fibers in patients with Parkinson’s disease and multiple sclerosis in deep brain stimulation
Abstract Background We wanted to depict fibers of the dentatorubrothalamic tract in patients with Parkinson’s disease and multiple sclerosis in order to use this knowledge for clinical routine and to show its relation to the corticospinal tract for deep brain stimulation. Fibers of these white matter tracts were depicted between February 2014 and February 2015… Continue reading Depiction of dentatorubrothalamic tract fibers in patients with Parkinson’s disease and multiple sclerosis in deep brain stimulation
Secondary consent to biospecimen use in a prostate cancer biorepository
Abstract Background Biorepository research has substantial societal benefits. This is one of the few studies to focus on male willingness to allow future research use of biospecimens. Methods This study analyzed the future research consent questions from a prostate cancer biorepository study (N = 1931). The consent form asked two questions regarding use of samples… Continue reading Secondary consent to biospecimen use in a prostate cancer biorepository
Knowledge of women in family planning and future desire to use contraception: a cross sectional survey in Urban Cameroon
Abstract Background The rate of modern contraceptive use will be on an increase and maternal mortality on a decrease if women had a good knowledge on family planning and its methods. This survey was designed to evaluate the knowledge and determine the future desires to use contraception among women in Urban Cameroon. Methods We conducted… Continue reading Knowledge of women in family planning and future desire to use contraception: a cross sectional survey in Urban Cameroon
Immune checkpoint inhibitors and response analysis: a tough challenge. A case report
Abstract Background Treatment of metastatic NSCLC patients with immune-checkpoint medicine is intriguing for the potential efficacy; however it may be difficult to evaluate the clinical response due to the lack of reliable immune-monitoring markers up to now and the possibility of radiological pseudo-progression. Case presentation Herein we report the case of a patient ex-smoker with… Continue reading Immune checkpoint inhibitors and response analysis: a tough challenge. A case report
The association between caregiver well-being and care provided to persons with Alzheimer’s disease and related disorders
Abstract Background Alzheimer’s disease and related disorders (ADRD) are some of the leading causes of morbidity in developed nations. Unpaid family caregivers are primarily responsible for providing the care and support needed by persons with ADRD. In the process of caring for their loved ones with ADRD, caregivers often have to deal with multiple challenges,… Continue reading The association between caregiver well-being and care provided to persons with Alzheimer’s disease and related disorders
DNA analysis of molluscs from a museum wet collection: a comparison of different extraction methods
Abstract Background DNA isolation and PCR amplification from molluscan taxa is considered as problematic because polysaccharides in tissue and mucus presumably co-precipitate with the DNA and inhibit the activity of DNA polymerase. In the present study we tested two common extraction methods on specimens from the mollusc collection of the Natural History Museum Vienna (NHMW).… Continue reading DNA analysis of molluscs from a museum wet collection: a comparison of different extraction methods
A melanoma family
from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/29Lkydy via IFTTT
No Muscle is an Island: Integrative Perspectives on Muscle Fatigue.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
[image: wk-health-logo.gif] Muscle fatigue has been studied with a variety approaches, tools and technologies. The foci of these studies have ranged tremendously, from molecules to the entire organism. Single cell and animal models have been used to gain mechanistic insight into the fatigue process. The theme of this review is the concept that the mechanisms of muscle fatigue do not occur in isolation in vivo: muscular work is supported by many complex physiological systems, any of which could fail during exercise and thus contribute to fatigue. To advance our overall understanding... περισσότερα »
Cardiorespiratory Response to Different Exercise Tests in Interstitial Lung Disease.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
[image: wk-health-logo.gif] Introduction: The 6-minute stepper test (6MST) has been used as an alternative to the 6-minute walk test (6MWT) to assess exercise tolerance in patients with interstitial lung disease (ILD). Recent data suggest that the tests may involve different energy pathways and cardiorespiratory responses. We thus aimed to compare the cardiorespiratory responses of ILD patients during the 6MWT and the 6MST. Methods: Thirty-one patients with ILD were randomised to perform both tests in the order 6MST->6MWT (n=16) or 6MWT->6MST (n=15). Gas exchange, heart rate, and p... περισσότερα »
Impact of 12-s Rule on Performance and Muscle Damage of Baseball Pitchers.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
[image: wk-health-logo.gif] Introduction: A recent US Major League Baseball (MLB) rule change requires baseball pitchers to deliver pitches within 12 sec. Purposes: To examine the effect of three, between-pitch rest intervals on throwing performance during a simulated 7-inning game and muscle damage during post-game recovery. Design: A randomized counter-balanced study. Methods: Seven intercollegiate pitchers threw 15 pitches per inning for 7 innings with rest interval trials of 8, 12, and 20 sec between pitches and 5 min between innings. Pitchers threw aimed fastballs at their bes... περισσότερα »
The Influence of Maturation on Sprint Performance in Boys over a 21-Month Period.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
[image: wk-health-logo.gif] Purpose: This study examined how the characteristics of maximal overground sprint performance are affected by the period of peak height velocity (PHV) in boys. Methods: One hundred and eighty-nine school-aged boys completed two assessments of maximal sprint performance, separated by a 21-month period. Kinematic characteristics of sprint performance were collected during a 30 m sprint using a floor-level optical measurement system, with modelled force and stiffness characteristics also calculated. Participants were grouped according to maturation using a ... περισσότερα »
Additive Benefits of [beta]-Alanine Supplementation and Sprint-Interval Training.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
[image: wk-health-logo.gif] Purpose: The present study investigated the effects of [beta]-alanine supplementation only, and in combination with sprint-interval training (SIT), on training intensity, and energy provision and performance during exhaustive supramaximal-intensity cycling and a 4- and 10-km time trial (TT). Methods: Fourteen trained cyclists (VO2max = 4.5 +/- 0.6 L[middle dot]min-1) participated in this placebo-controlled, double-blind study. Subjects performed a supramaximal cycling test to exhaustion (equivalent to 120% VO2max) and a 4- and 10-km TT and 4 x 1-km sprin... περισσότερα »
Experiences applying for and understanding health insurance under Massachusetts health care reform
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background The Affordable Care Act was modeled on the Massachusetts Health Reform of 2006, which reduced the number of uninsured largely through a Medicaid expansion and the provision of publicly subsidized insurance obtained through a Health Benefits Exchange. Methods We surveyed a convenience sample of 780 patients seeking care in a safety-net system who […]
Expansion patterns in surgically assisted rapid maxillary expansion
Abstract Objectives The purpose of this work was to compare the patterns of expansion resulting from a tooth-borne hyrax appliance and a bone-borne transpalatal distractor in patients treated by surgically assisted rapid maxillary expansion (SARME). Methods A total of 28 patients with transverse maxillary hypoplasia were treated by SARME, using a hyrax appliance in 12 and a transpalatal distractor in 16 cases. Before and after palatal expansion, an impression of each maxilla was taken. Casts fabricated on this basis were digitized with a 3D scanner. Based on the resultant virtual... περισσότερα »
Expansion patterns in surgically assisted rapid maxillary expansion
Abstract Objectives The purpose of this work was to compare the patterns of expansion resulting from a tooth-borne hyrax appliance and a bone-borne transpalatal distractor in patients treated by surgically assisted rapid maxillary expansion (SARME). Methods A total of 28 patients with transverse maxillary hypoplasia were treated by SARME, using a hyrax appliance in 12 and a transpalatal distractor in 16 cases. Before and after palatal expansion, an impression of each maxilla was taken. Casts fabricated on this basis were digitized with a 3D scanner. Based on the resultant virtual... περισσότερα »
Expansion patterns in surgically assisted rapid maxillary expansion
Abstract Objectives The purpose of this work was to compare the patterns of expansion resulting from a tooth-borne hyrax appliance and a bone-borne transpalatal distractor in patients treated by surgically assisted rapid maxillary expansion (SARME). Methods A total of 28 patients with transverse maxillary hypoplasia were treated by SARME, using a hyrax appliance in 12 and a transpalatal distractor in 16 cases. Before and after palatal expansion, an impression of each maxilla was taken. Casts fabricated on this basis were digitized with a 3D scanner. Based on the resultant virtual... περισσότερα »
The future of pediatric dentistry education and curricula: a Chilean perspective
Abstract Background A meeting was organised to consolidate a network of researchers and academics from Australia, Brazil, Chile, the UK and the USA, relating to Early Childhood Caries (ECC) and Dental Trauma (DT). As part of this meeting, a dedicated session was held on the future of paediatric dental education and curricula. Twenty-four paediatric dentistry (PD) academics, representing eight Chilean dental schools, and three international specialists (from Brazil and Latvia) participated in group discussions facilitated by five members of the ECC/DT International Collaborative Ne... περισσότερα »
Influence of different post-interventional maintenance concepts on periodontal outcomes: an evaluation of three systematic reviews
Abstract Background To selectively review the existing literature on post-interventional maintenance protocols in patients with periodontal disease receiving either non-surgical or surgical periodontal treatment. Methods Three systematic reviews with different periodontal interventions, i.e. scaling and root planing (SRP), SRP with adjunctive antibiotics or regenerative periodontal surgery were evaluated focusing on their post-interventional maintenance care. Due to the early publication of one review an additional literature search update was undertaken. The search was executed ... περισσότερα »
A novel enteric neuron-glia coculture system reveals the role of glia in neuronal development
Abstract In the nervous system, the formation of neuronal circuitry results from a complex and coordinated action of intrinsic and extrinsic factors. In the CNS, extrinsic mediators derived from astrocytes have been shown to play a key role in neuronal maturation, including dendritic shaping, axon guidance and synaptogenesis. In the enteric nervous system (ENS), the potential role of enteric glial cells (EGCs) in the maturation of developing enteric neuronal circuit is currently unknown. A major obstacle in addressing this question is the difficulty to obtain a valuable experimental... περισσότερα »
Y-27632, a Rho-Associated Protein Kinase Inhibitor, Inhibits Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
We examined the effects of the Rho-associated protein kinase (ROCK) inhibitor Y-27632 on voltage-dependent K+ (Kv) channels in rabbit coronary arterial smooth muscle cells using the whole-cell patch clamp technique. Y-27632 reduced the amplitude of the Kv current in a concentration-dependent manner, with an IC50 of 0.87 ± 0.06 μmol/l and a Hill coefficient of […]
A phase I study of the combination of panitumumab and bevacizumab in KRAS wild-type colorectal cancer patients previously treated with fluoropyrimidine, oxaliplatin, irinotecan and bevacizumab
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Purpose The clinical benefit of combination treatment with panitumumab and bevacizumab (PB) based on bevacizumab beyond progression (BBP) after the failure of second-line chemotherapy remains unclear. We assessed the tolerability and efficacy of PB as BBP in Japanese patients with metastatic colorectal cancer (mCRC). Methods This phase I study comprised two parts: (1) PB […]
Association of Aortic Compliance and Brachial Endothelial Function with Cerebral Small Vessel Disease in Type 2 Diabetes Mellitus Patients: Assessment with High-Resolution MRI
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective. To assess the possible association of aortic compliance and brachial endothelial function with cerebral small vessel disease in type 2 diabetes mellitus (DM2) patients by using 3.0 T high-resolution magnetic resonance imaging. Methods. Sixty-two clinically confirmed DM2 patients (25 women and 37 men; mean age: years) were prospectively enrolled for noninvasive MR examinations of the […]
Research on Preference Polyhedron Model Based Evolutionary Multiobjective Optimization Method for Multilink Transmission Mechanism Conceptual Design
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
To make the optimal design of the multilink transmission mechanism applied in mechanical press, the intelligent optimization techniques are explored in this paper. A preference polyhedron model and new domination relationships evaluation methodology are proposed for the purpose of reaching balance among kinematic performance, dynamic performance, and other performances of the multilink transmission mechanism during […]
A Location-Inventory-Routing Problem in Forward and Reverse Logistics Network Design
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
We study a new problem of location-inventory-routing in forward and reverse logistic (LIRP-FRL) network design, which simultaneously integrates the location decisions of distribution centers (DCs), the inventory policies of opened DCs, and the vehicle routing decision in serving customers, in which new goods are produced and damaged goods are repaired by a manufacturer and then […]
A Rare Case of Tuberculosis with Sacrococcygeal Involvement Miming a Neoplasm
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Infection of the lumbosacral junction by tuberculosis is quite rare and occurs in only 1 to 2% of all cases of spinal tuberculosis; moreover, isolated sacrococcygeal or coccygeal tuberculosis is much rarer. Failure to identify and treat these areas of involvement at an early stage may lead to serious complications such as vertebral collapse, spinal […]
Robust Optimization on Regional WCO-for-Biodiesel Supply Chain under Supply and Demand Uncertainties
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This paper aims to design a robust waste cooking oil- (WCO-) for-biodiesel supply chain under WCO supply and price as well as biodiesel demand and price uncertainties, so as to improve biorefineries’ ability to cope with the poor environment. A regional supply chain is firstly introduced based on the biggest WCO-for-biodiesel company in Changzhou, Jiangsu […]
Research on E-Commerce Platform-Based Personalized Recommendation Algorithm
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Aiming at data sparsity and timeliness in traditional E-commerce collaborative filtering recommendation algorithms, when constructing user-item rating matrix, this paper utilizes the feature that commodities in E-commerce system belong to different levels to fill in nonrated items by calculating RF/IRF of the commodity’s corresponding level. In the recommendation prediction stage, considering timeliness of the recommendation […]
Modeling and Optimization of Vehicle Suspension Employing a Nonlinear Fluid Inerter
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
An ideal inerter has been applied to various vibration engineering fields because of its superior vibration isolation performance. This paper proposes a new type of fluid inerter and analyzes the nonlinearities including friction and nonlinear damping force caused by the viscosity of fluid. The nonlinear model of fluid inerter is demonstrated by the experiments analysis. […]
Preparation and Viscoelastic Properties of Composite Fibres Containing Cellulose Nanofibrils: Formation of a Coherent Fibrillar Network
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Composite fibres with a matrix of poly(ethylene glycol) (PEG) and cellulose nanofibrils (CNF) as reinforcing elements were produced using a capillary viscometer. Two types of CNF were employed: one based on carboxymethylated pulp fibres and the other on TEMPO-oxidized pulp. Part of the latter nanofibrils was also grafted with PEG in order to improve the […]
Outcomes of 6.5-mm Hydrophilic Implants and Long Implants Placed with Lateral Sinus Floor Elevation in the Atrophic Posterior Maxilla: A Prospective, Randomized Controlled Clinical Comparison
Abstract Background Very few controlled studies have compared short and long implants placed with appropriate sinus floor elevation techniques. Purpose To compare the 2-year outcomes of 6.5-mm hydrophilic implants placed with osteotome sinus floor elevation (OSFE) and standard implants placed with lateral sinus floor elevation in patients with a severely atrophic posterior maxilla. Materials and Methods Thirty-eight patients with a residual bone height of 4–5 mm were randomized to receive one of the two above-mentioned treatments. Intra- and postoperative complications were rec... περισσότερα »
ITAC induces the melanocytic migration and hypopigmentation through destabilizing p53 via HDAC5: A possible role of ITAC in pigment-related disorders
Summary Background Cell migration plays a major role in the immune response and in tumorigenesis. Interferon-inducible T-cell alpha chemoattractant (ITAC) elicits a strong chemotactic response from immune cells. Objectives To examine the effect of ITAC on the melanocytic migration and pigmentation and its involvement in the related disorders, and to investigate potential key players in these processes. Methods Human melanocytes or melanoma cells were treated with ITAC and migration assay was performed. Global gene expression analysis was performed to find genes regulated by ITA... περισσότερα »
Cardiorespiratory Response to Different Exercise Tests in Interstitial Lung Disease.
[image: wk-health-logo.gif] Introduction: The 6-minute stepper test (6MST) has been used as an alternative to the 6-minute walk test (6MWT) to assess exercise tolerance in patients with interstitial lung disease (ILD). Recent data suggest that the tests may involve different energy pathways and cardiorespiratory responses. We thus aimed to compare the cardiorespiratory responses of ILD patients during the 6MWT and the 6MST. Methods: Thirty-one patients with ILD were randomised to perform both tests in the order 6MST->6MWT (n=16) or 6MWT->6MST (n=15). Gas exchange, heart rate, and p... περισσότερα »
Impact of 12-s Rule on Performance and Muscle Damage of Baseball Pitchers.
[image: wk-health-logo.gif] Introduction: A recent US Major League Baseball (MLB) rule change requires baseball pitchers to deliver pitches within 12 sec. Purposes: To examine the effect of three, between-pitch rest intervals on throwing performance during a simulated 7-inning game and muscle damage during post-game recovery. Design: A randomized counter-balanced study. Methods: Seven intercollegiate pitchers threw 15 pitches per inning for 7 innings with rest interval trials of 8, 12, and 20 sec between pitches and 5 min between innings. Pitchers threw aimed fastballs at their bes... περισσότερα »
The Influence of Maturation on Sprint Performance in Boys over a 21-Month Period.
[image: wk-health-logo.gif] Purpose: This study examined how the characteristics of maximal overground sprint performance are affected by the period of peak height velocity (PHV) in boys. Methods: One hundred and eighty-nine school-aged boys completed two assessments of maximal sprint performance, separated by a 21-month period. Kinematic characteristics of sprint performance were collected during a 30 m sprint using a floor-level optical measurement system, with modelled force and stiffness characteristics also calculated. Participants were grouped according to maturation using a ... περισσότερα »
Additive Benefits of [beta]-Alanine Supplementation and Sprint-Interval Training.
[image: wk-health-logo.gif] Purpose: The present study investigated the effects of [beta]-alanine supplementation only, and in combination with sprint-interval training (SIT), on training intensity, and energy provision and performance during exhaustive supramaximal-intensity cycling and a 4- and 10-km time trial (TT). Methods: Fourteen trained cyclists (VO2max = 4.5 +/- 0.6 L[middle dot]min-1) participated in this placebo-controlled, double-blind study. Subjects performed a supramaximal cycling test to exhaustion (equivalent to 120% VO2max) and a 4- and 10-km TT and 4 x 1-km sprin... περισσότερα »
Persistent Muscle Inhibition after ACL Reconstruction: Role of Reflex Excitability.
[image: wk-health-logo.gif] Purpose: Persistent voluntary quadriceps activation deficits are common following anterior cruciate ligament reconstruction (ACLR), but the direct causes are unclear. The primary purpose of this study was to determine whether spinal reflex excitability deficits are present in individuals with a history of ACLR, and secondarily to determine if spinal reflex excitability predicts which individuals possess full voluntary quadriceps activation. Methods: One hundred and forty-seven individuals (74 Healthy and 73 ACLR) participated in this cross-sectional, cas... περισσότερα »
Muscle Fatigue from the Perspective of a Single Cross-bridge.
[image: wk-health-logo.gif] Repeated intense stimulation of skeletal muscle rapidly decreases its force and motion generating capacity. This type of fatigue can be temporally correlated with the accumulation of metabolic by-products, including phosphate (Pi) and protons (H+). Experiments on skinned single muscle fibers demonstrate that elevated concentrations of these ions can reduce maximal isometric force, unloaded shortening velocity and peak power, providing strong evidence for a causative role in the fatigue process. This appears to be due, in part, to their direct effect on m... περισσότερα »
PDPR Gene Expression Correlates with Exercise-Training Insulin Sensitivity Changes.
[image: wk-health-logo.gif] Purpose: Whole body insulin sensitivity (Si) typically improves following aerobic exercise training; however, individual responses can be highly variable. The purpose of this study was to use global gene expression to identify skeletal muscle genes that correlate with exercise-induced Si changes. Methods: Longitudinal cohorts from the Studies of Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) were utilized as Discovery (Affymetrix) and Confirmation (Illumina) of vastus lateralis gene expression profiles. Discovery (n=39; 21 men) a... περισσότερα »
Periodization Strategies in Older Adults: Impact on Physical Function and Health.
[image: wk-health-logo.gif] Purpose: This study compared the effect of periodized versus non-periodized (NP) resistance training (RT) on physical function and health outcomes in older adults. Methods: Forty-one apparently healthy untrained older adults (female=21, male=20; 70.9 +/- 5.1 y; 166.3 +/- 8.2 cm; 72.9 +/- 13.4 kg) were recruited and randomly stratified to a NP, block periodized (BP), or daily undulating periodized (DUP) training group. Outcome measures were assessed at baseline and following a 22-week x 3 d.wk-1 RT intervention, including; anthropometrics, body compositio... περισσότερα »
Neuromuscular Changes and Damage after Isoload versus Isokinetic Eccentric Exercise.
[image: wk-health-logo.gif] Purpose: This study compared the effects of isoload (IL) and isokinetic (IK) knee extensor eccentric exercises on changes in muscle damage and neuromuscular parameters to test the hypothesis that the changes would be different after IL and IK exercises. Methods: Twenty-two young men were paired based on their strength and placed to IL (N = 11) or IK (N = 11) group. IL group performed 15 sets of 10 eccentric contractions with a 150% of pre-determined 1-RM load. IK group performed 15 sets of a number of maximal eccentric contractions matched set-by-set for... περισσότερα »
Expansion patterns in surgically assisted rapid maxillary expansion
Abstract Objectives The purpose of this work was to compare the patterns of expansion resulting from a tooth-borne hyrax appliance and a bone-borne transpalatal distractor in patients treated by surgically assisted rapid maxillary expansion (SARME). Methods A total of 28 patients with transverse maxillary hypoplasia were treated by SARME, using a hyrax appliance in 12 and a transpalatal distractor in 16 cases. Before and after palatal expansion, an impression of each maxilla was taken. Casts fabricated on this basis were digitized with a 3D scanner. Based on the resultant virtual... περισσότερα »
Expansion patterns in surgically assisted rapid maxillary expansion
Abstract Objectives The purpose of this work was to compare the patterns of expansion resulting from a tooth-borne hyrax appliance and a bone-borne transpalatal distractor in patients treated by surgically assisted rapid maxillary expansion (SARME). Methods A total of 28 patients with transverse maxillary hypoplasia were treated by SARME, using a hyrax appliance in 12 and a transpalatal distractor in 16 cases. Before and after palatal expansion, an impression of each maxilla was taken. Casts fabricated on this basis were digitized with a 3D scanner. Based on the resultant virtual... περισσότερα »
Expansion patterns in surgically assisted rapid maxillary expansion
Abstract Objectives The purpose of this work was to compare the patterns of expansion resulting from a tooth-borne hyrax appliance and a bone-borne transpalatal distractor in patients treated by surgically assisted rapid maxillary expansion (SARME). Methods A total of 28 patients with transverse maxillary hypoplasia were treated by SARME, using a hyrax appliance in 12 and a transpalatal distractor in 16 cases. Before and after palatal expansion, an impression of each maxilla was taken. Casts fabricated on this basis were digitized with a 3D scanner. Based on the resultant virtual... περισσότερα »
The future of pediatric dentistry education and curricula: a Chilean perspective
Abstract Background A meeting was organised to consolidate a network of researchers and academics from Australia, Brazil, Chile, the UK and the USA, relating to Early Childhood Caries (ECC) and Dental Trauma (DT). As part of this meeting, a dedicated session was held on the future of paediatric dental education and curricula. Twenty-four paediatric dentistry (PD) academics, representing eight Chilean dental schools, and three international specialists (from Brazil and Latvia) participated in group discussions facilitated by five members of the ECC/DT International Collaborative Ne... περισσότερα »
Influence of different post-interventional maintenance concepts on periodontal outcomes: an evaluation of three systematic reviews
Abstract Background To selectively review the existing literature on post-interventional maintenance protocols in patients with periodontal disease receiving either non-surgical or surgical periodontal treatment. Methods Three systematic reviews with different periodontal interventions, i.e. scaling and root planing (SRP), SRP with adjunctive antibiotics or regenerative periodontal surgery were evaluated focusing on their post-interventional maintenance care. Due to the early publication of one review an additional literature search update was undertaken. The search was executed ... περισσότερα »
Outcomes of 6.5-mm Hydrophilic Implants and Long Implants Placed with Lateral Sinus Floor Elevation in the Atrophic Posterior Maxilla: A Prospective, Randomized Controlled Clinical Comparison
Abstract Background Very few controlled studies have compared short and long implants placed with appropriate sinus floor elevation techniques. Purpose To compare the 2-year outcomes of 6.5-mm hydrophilic implants placed with osteotome sinus floor elevation (OSFE) and standard implants placed with lateral sinus floor elevation in patients with a severely atrophic posterior maxilla. Materials and Methods Thirty-eight patients with a residual bone height of 4–5 mm were randomized to receive one of the two above-mentioned treatments. Intra- and postoperative complications were rec... περισσότερα »
Effect of Associated Autoimmune Diseases on Type 1 Diabetes Mellitus Incidence and Metabolic Control in Children and Adolescents
Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases developing in childhood. The incidence of the disease in children increases for unknown reasons at a rate from 3 to 5% every year worldwide. The background of T1DM is associated with the autoimmune process of pancreatic beta cell destruction, which leads to absolute insulin deficiency and organ damage. Complex interactions between environmental and genetic factors contribute to the development of T1DM in genetically predisposed patients. The T1DM-inducing autoimmune process can also affect other organs, res... περισσότερα »
BRAF and NRAS mutations in Russian melanoma patients: results of a nationwide study.
Distribution of actionable mutations in melanoma may show considerable geographic variations. Given the importance of genetic testing for the proper use of targeted drugs, we carried out the first-in-Russia nationwide molecular epidemiological study for melanoma. Sanger sequencing analysis for BRAF (exon 15) and NRAS (exons 2-4) genes was carried out for patients with the stage IIIB or IV disease from 46 cancer centers located throughout the country. BRAF mutations were identified in 625/1034 (60.4%) melanoma samples. BRAF c.1799T>A (p.V600E) substitution was the most prevalent, bei... περισσότερα »
BRAF and NRAS mutations in Russian melanoma patients: results of a nationwide study.
Distribution of actionable mutations in melanoma may show considerable geographic variations. Given the importance of genetic testing for the proper use of targeted drugs, we carried out the first-in-Russia nationwide molecular epidemiological study for melanoma. Sanger sequencing analysis for BRAF (exon 15) and NRAS (exons 2-4) genes was carried out for patients with the stage IIIB or IV disease from 46 cancer centers located throughout the country. BRAF mutations were identified in 625/1034 (60.4%) melanoma samples. BRAF c.1799T>A (p.V600E) substitution was the most prevalent, bei... περισσότερα »
Expansion patterns in surgically assisted rapid maxillary expansion
Abstract Objectives The purpose of this work was to compare the patterns of expansion resulting from a tooth-borne hyrax appliance and a bone-borne transpalatal distractor in patients treated by surgically assisted rapid maxillary expansion (SARME). Methods A total of 28 patients with transverse maxillary hypoplasia were treated by SARME, using a hyrax appliance in 12 and a transpalatal distractor in 16 cases. Before and after palatal expansion, an impression of each maxilla was taken. Casts fabricated on this basis were digitized with a 3D scanner. Based on the resultant virtual... περισσότερα »
Expansion patterns in surgically assisted rapid maxillary expansion
Abstract Objectives The purpose of this work was to compare the patterns of expansion resulting from a tooth-borne hyrax appliance and a bone-borne transpalatal distractor in patients treated by surgically assisted rapid maxillary expansion (SARME). Methods A total of 28 patients with transverse maxillary hypoplasia were treated by SARME, using a hyrax appliance in 12 and a transpalatal distractor in 16 cases. Before and after palatal expansion, an impression of each maxilla was taken. Casts fabricated on this basis were digitized with a 3D scanner. Based on the resultant virtual... περισσότερα »
Expansion patterns in surgically assisted rapid maxillary expansion
Abstract Objectives The purpose of this work was to compare the patterns of expansion resulting from a tooth-borne hyrax appliance and a bone-borne transpalatal distractor in patients treated by surgically assisted rapid maxillary expansion (SARME). Methods A total of 28 patients with transverse maxillary hypoplasia were treated by SARME, using a hyrax appliance in 12 and a transpalatal distractor in 16 cases. Before and after palatal expansion, an impression of each maxilla was taken. Casts fabricated on this basis were digitized with a 3D scanner. Based on the resultant virtual... περισσότερα »
The future of pediatric dentistry education and curricula: a Chilean perspective
Abstract Background A meeting was organised to consolidate a network of researchers and academics from Australia, Brazil, Chile, the UK and the USA, relating to Early Childhood Caries (ECC) and Dental Trauma (DT). As part of this meeting, a dedicated session was held on the future of paediatric dental education and curricula. Twenty-four paediatric dentistry (PD) academics, representing eight Chilean dental schools, and three international specialists (from Brazil and Latvia) participated in group discussions facilitated by five members of the ECC/DT International Collaborative Ne... περισσότερα »
Influence of different post-interventional maintenance concepts on periodontal outcomes: an evaluation of three systematic reviews
Abstract Background To selectively review the existing literature on post-interventional maintenance protocols in patients with periodontal disease receiving either non-surgical or surgical periodontal treatment. Methods Three systematic reviews with different periodontal interventions, i.e. scaling and root planing (SRP), SRP with adjunctive antibiotics or regenerative periodontal surgery were evaluated focusing on their post-interventional maintenance care. Due to the early publication of one review an additional literature search update was undertaken. The search was executed ... περισσότερα »
Vaccines and immunization strategies for dengue prevention
[image: CC-BY.jpg] *Vaccines and immunization strategies for dengue prevention* Emerging Microbes & Infections 5, e77 (July 2016). doi:10.1038/emi.2016.74 Authors: Yang Liu, Jianying Liu & Gong Cheng from Infection via ola Kala on Inoreader http://ift.tt/29T2USa via IFTTT
EV-A71 vaccine licensure: a first step for multivalent enterovirus vaccine to control HFMD and other severe diseases
[image: CC-BY.jpg] *EV-A71 vaccine licensure: a first step for multivalent enterovirus vaccine to control HFMD and other severe diseases* Emerging Microbes & Infections 5, e75 (July 2016). doi:10.1038/emi.2016.73 Authors: Qunying Mao, Yiping Wang, Lianlian Bian, Miao Xu & Zhenglun Liang from Infection via ola Kala on Inoreader http://ift.tt/29Tfjtp via IFTTT
Molecular characterization of H6 subtype influenza viruses in southern China from 2009 to 2011
[image: emi201671f1th.jpg] *Molecular characterization of H6 subtype influenza viruses in southern China from 2009 to 2011* Emerging Microbes & Infections 5, e73 (July 2016). doi:10.1038/emi.2016.71 Authors: Shumei Zou, Rongbao Gao, Ye Zhang, Xiaodan Li, Wenbing Chen, Tian Bai, Libo Dong, Dayan Wang & Yuelong Shu from Infection via ola Kala on Inoreader http://ift.tt/29TfgO5 via IFTTT
Intense circulation of A/H5N1 and other avian influenza viruses in Cambodian live-bird markets with serological evidence of sub-clinical human infections
[image: emi201669f1th.jpg] *Intense circulation of A/H5N1 and other avian influenza viruses in Cambodian live-bird markets with serological evidence of sub-clinical human infections* Emerging Microbes & Infections 5, e70 (July 2016). doi:10.1038/emi.2016.69 Authors: Srey Viseth Horm, Arnaud Tarantola, Sareth Rith, Sowath Ly, Juliette Gambaretti, Veasna Duong, Phalla Y, San Sorn, Davun Holl, Lotfi Allal, Wantanee Kalpravidh, Philippe Dussart, Paul F Horwood & Philippe Buchy from Infection via ola Kala on Inoreader http://ift.tt/29TfMf3 via IFTTT
Expansion patterns in surgically assisted rapid maxillary expansion
Abstract Objectives The purpose of this work was to compare the patterns of expansion resulting from a tooth-borne hyrax appliance and a bone-borne transpalatal distractor in patients treated by surgically assisted rapid maxillary expansion (SARME). Methods A total of 28 patients with transverse maxillary hypoplasia were treated by SARME, using a hyrax appliance in 12 and a transpalatal distractor in 16 cases. Before and after palatal expansion, an impression of each maxilla was taken. Casts fabricated on this basis were digitized with a 3D scanner. Based on the resultant virtual... περισσότερα »
Expansion patterns in surgically assisted rapid maxillary expansion
AbstractObjectives The purpose of this work was to compare the patterns of expansion resulting from a tooth-borne hyrax appliance and a bone-borne transpalatal distractor in patients treated by surgically assisted rapid maxillary expansion (SARME). Methods A total of 28 patients with transverse maxillary hypoplasia were treated by SARME, using a hyrax appliance in 12 and a transpalatal distractor in 16 cases. Before and after palatal expansion, an impression of each maxilla was taken. Casts fabricated on this basis were digitized with a 3D scanner. Based on the resultant virtual mo... περισσότερα »
Optimal Bounds for the Variance of Self-Intersection Local Times
For a -valued random walk , let be its local time at the site . For , define the -fold self-intersection local time as . Also let be the corresponding quantities for the simple random walk in . Without imposing any moment conditions, we show that the variance of the self-intersection local time of any… Continue reading Optimal Bounds for the Variance of Self-Intersection Local Times
Potential of Inducible Nitric Oxide Synthase as a Therapeutic Target for Allergen-Induced Airway Hyperresponsiveness: A Critical Connection to Nitric Oxide Levels and PARP Activity
Although expression of inducible NO synthase (iNOS) in the lungs of asthmatics and associated nitrosative damage are established, iNOS failed as a therapeutic target for blocking airway hyperresponsiveness (AHR) and inflammation in asthmatics. This dichotomy calls for better strategies with which the enzyme is adequately targeted. Here, we confirm iNOS expression in the asthmatic lung… Continue reading Potential of Inducible Nitric Oxide Synthase as a Therapeutic Target for Allergen-Induced Airway Hyperresponsiveness: A Critical Connection to Nitric Oxide Levels and PARP Activity
Development of a Low-Level Control System for the ROV Visor3
This paper addresses the development of the simulation of the low-level control system for the underwater remotely operated vehicle Visor3. The 6-DOF mathematical model of Visor3 is presented using two coordinated systems: Earth-fixed and body-fixed frames. The navigation, guidance, and control (NGC) structure is divided into three layers: the high level or the mission planner;… Continue reading Development of a Low-Level Control System for the ROV Visor3
Adaptive Fuzzy Sliding Mode Tracking Control of Uncertain Underactuated Nonlinear Systems: A Comparative Study
The trajectory tracking of underactuated nonlinear system with two degrees of freedom is tackled by an adaptive fuzzy hierarchical sliding mode controller. The proposed control law solves the problem of coupling using a hierarchical structure of the sliding surfaces and chattering by adopting different reaching laws. The unknown system functions are approximated by fuzzy logic… Continue reading Adaptive Fuzzy Sliding Mode Tracking Control of Uncertain Underactuated Nonlinear Systems: A Comparative Study
Effects of Ving Tsun Chinese Martial Art Training on Upper Extremity Muscle Strength and Eye-Hand Coordination in Community-Dwelling Middle-Aged and Older Adults: A Pilot Study
Objectives. To evaluate the effects of Ving Tsun (VT) martial art training on the upper extremity muscle strength and eye-hand coordination of middle-aged and older adults. Methods. This study used a nonequivalent pretest-posttest control group design. Forty-two community-dwelling healthy adults participated in the study; 24 (mean age ± SD = years) underwent VT training for… Continue reading Effects of Ving Tsun Chinese Martial Art Training on Upper Extremity Muscle Strength and Eye-Hand Coordination in Community-Dwelling Middle-Aged and Older Adults: A Pilot Study
Progression of motor subtypes in Huntington’s disease: a 6-year follow-up study
Abstract The objective of this study is to investigate the progression of predominantly choreatic and hypokinetic-rigid signs in Huntington’s disease (HD) and their relationship with cognitive and general functioning over time. The motor signs in HD can be divided into predominantly choreatic and hypokinetic-rigid subtypes. It has been reported in cross-sectional studies that predominantly choreatic… Continue reading Progression of motor subtypes in Huntington’s disease: a 6-year follow-up study
Carotid intima-media thickness and cognitive function in a middle-aged and older adult community: a cross-sectional study
Abstract The relationship between atherosclerosis and cognitive function is less well studied in Chinese populations. In addition, the results among middle-aged adults have been mixed. We aimed to investigate the association of atherosclerosis measured by carotid intima-media thickness (CIMT) and cognitive function in middle-aged and older adults from a Chinese community. Participants in the Asymptomatic… Continue reading Carotid intima-media thickness and cognitive function in a middle-aged and older adult community: a cross-sectional study
Vertigo with sudden hearing loss: audio-vestibular characteristics
Abstract Acute vertigo with sudden sensorineural hearing loss (SSNHL) is a rare clinical emergency. Here, we report the audio-vestibular test profiles of 27 subjects who presented with these symptoms. The vestibular test battery consisted of a three-dimensional video head impulse test (vHIT) of semicircular canal function and recording ocular and cervical vestibular-evoked myogenic potentials (oVEMP,… Continue reading Vertigo with sudden hearing loss: audio-vestibular characteristics
Investigating into composition, distribution, sources and health risk of phthalic acid esters in street dust of Xi’an City, Northwest China
Abstract Phthalic acid esters (PAEs) are widely used as plasticizers and in consumer products, which may enter the environment and present risks to human health. U.S. EPA classifies six PAEs as priority pollutants, which could be accumulated in street dust at the interface of atmosphere, biosphere and geosphere. This study collected a total of 58… Continue reading Investigating into composition, distribution, sources and health risk of phthalic acid esters in street dust of Xi’an City, Northwest China
Factors affecting observer agreement in morphological evaluation of mandibular cortical bone on panoramic radiographs
Abstract Objectives To assess intra- and inter-observer agreement in the morphological evaluation of mandibular cortical bone on panoramic radiographs, to examine factors affecting the diagnosis, and to determine causes of diagnostic discrepancy. Methods Three experienced observers evaluated mandibular cortical shape on panoramic radiographs of 228 females, and divided the images into three classes. The intra-… Continue reading Factors affecting observer agreement in morphological evaluation of mandibular cortical bone on panoramic radiographs
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