Osimertinib (Tagrisso™, AZD9291) is an oral, third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI)
Osimertinib: First Global Approval: AbstractOsimertinib (Tagrisso™, AZD9291) is an oral, third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) that is being developed by AstraZeneca for the treatment of advanced non-small cell lung cancer (NSCLC). Osimertinib has been designed to target the *EGFR* T790M mutation that is often present in NSCLC patients with acquired EGFR TKI resistance, while sparing wild-type *EGFR*. In November 2015, the tablet formulation of osimertinib was granted accelerated approval in the USA for the treatment of patients with...περισσότερα »
Intranasal curcumin ameliorates airway inflammation and obstruction
by regulating MAPKinase activation (p38, Erk and JNK) and prostaglandin D2 release in murine model of asthma via ScienceDirect Publication: International Immunopharmacology Publication date: February 2016 *Source:*International Immunopharmacology, Volume 31 Author(s): Subhashini, Preeti S. Chauhan, D. Dash, B.N. Paul, Rashmi Singh Asthma, a multifactorial, chronic inflammatory disease encompasses multiple complex pathways releasing number of mediators by activated mast cells, eosinophils and T lymphocytes, leading to its severity. Presently available medications are associated with cer... περισσότερα »
Vasovagal Syncope
Pulse wave analysis of the aortic pressure waveform in patients with vasovagal syncope: AbstractVascular reflex mechanisms contribute to vasovagal syncope. However, the alterations in central haemodynamics in patients with vasovagal syncope are unknown. 30 consecutive patients (36.5 ± 15 years, 14 females) with recurrent vasovagal syncope (VVS) and a positive tilt table test were compared to 39 age- and sex-matched controls (36.9 ± 16 years, 15 females) with a negative tilt table result and no history of syncope. Central aortic pressure parameters including augmentation index and c...περισσότερα »
Sleep-related autonomic overactivity in a general elderly population
Sleep-related autonomic overactivity in a general elderly population and its relationship to cardiovascular regulation: AbstractAlteration in cardiac autonomic activity during sleep is a common feature of sleep disorders. Diurnal sympathetic overactivity is a possible consequence and could contribute to future cardiovascular complications. The aim of this study is to assess the relationship between cardiac autonomic activity during sleep and diurnal autonomic cardiovascular control. In a large cohort (*n* = 1011) of subjects aged 65 years old (±0.4) free of cardiac and cerebrovascu... περισσότερα »
Categorization of patients with reflux symptoms referred for pH and impedance testing while off therapy.
Categorization of patients with reflux symptoms referred for pH and impedance testing while off therapy.: [image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles*Categorization of patients with reflux symptoms referred for pH and impedance testing while off therapy.* Clin Gastroenterol Hepatol. 2015;13(5):867-73 Authors: Cheng FK, Albert DM, Maydonovitch CL, Wong RK, Moawad FJ Abstract BACKGROUND & AIMS: Patients with suspected gastroesophageal reflux disease (GERD) often are treated empirically with proton pump inhibitors (PPIs). Patients whose symptoms are not reduced... περισσότερα »
Heller myotomy for achalasia
Heller myotomy for achalasia. From the open to the laparoscopic approach.: [image: http:--production.springer.de-OnlineReso] Related Articles*Heller myotomy for achalasia. From the open to the laparoscopic approach.* World J Surg. 2015;39(7):1603-7 Authors: Allaix ME, Patti MG Abstract The last three decades have witnessed a progressive evolution in the surgical treatment of esophageal achalasia, with a shift from open to a minimally invasive Heller myotomy. The laparoscopic approach is currently the standard of care with better short-term outcomes and similar long-term functional... περισσότερα »
IJMS, Vol. 17, Pages 61: Effect of Acetyl Group on Mechanical Properties of Chitin/Chitosan Nanocrystal: A Molecular Dynamics Study
Chitin fiber is the load-bearing component in natural chitin-based materials. In these materials, chitin is always partially deacetylated to different levels, leading to diverse material properties. In order to understand how the acetyl group enhances the fracture resistance capability of chitin fiber, we constructed atomistic models of chitin with varied acetylation degree and analyzed the hydrogen bonding pattern, fracture, and stress-strain behavior of these models. We notice that the acetyl group can contribute to the formation of hydrogen bonds that can stabilize the crystall... περισσότερα »
IJERPH, Vol. 13, Pages 102: Experimental Study on Ultrafine Particle Removal Performance of Portable Air Cleaners with Different Filters in an Office Room
Size- and time-dependent aerodynamic behaviors of indoor particles, including PM1.0, were evaluated in a school office in order to test the performance of air-cleaning devices using different filters. In-situ real-time measurements were taken using an optical particle counter. The filtration characteristics of filter media, including single-pass efficiency, volume and effectiveness, were evaluated and analyzed. The electret filter (EE) medium shows better initial removal efficiency than the high efficiency (HE) medium in the 0.3–3.5 μm particle size range, while under the same fac... περισσότερα »
IJERPH, Vol. 13, Pages 101: Ethnic Kawasaki Disease Risk Associated with Blood Mercury and Cadmium in U.S. Children
Kawasaki disease (KD) primarily affects children <5 years of age (75%–80%) and is currently the leading cause of acquired heart disease in developed nations. Even when residing in the West, East Asian children are 10 to 20 times more likely to develop KD. We hypothesized cultural variations influencing pediatric mercury (Hg) exposure from seafood consumption may mediate ethnic KD risk among children in the United States. Hospitalization rates of KD in US children aged 0–4 years (n = 10,880) and blood Hg levels in US children aged 1–5 years (n = 713) were determined using separate U... περισσότερα »
IJERPH, Vol. 13, Pages 100: Advanced Wastewater Treatment Engineering—Investigating Membrane Fouling in both Rotational and Static Membrane Bioreactor Systems Using Empirical Modelling
Advanced wastewater treatment using membranes are popular environmental system processes since they allow reuse and recycling. However, fouling is a key limiting factor and so proprietary systems such as Avanti's RPU-185 Flexidisks membrane bioreactor (MBR) use novel rotating membranes to assist in ameliorating it. In earlier research, this rotating process was studied by creating a simulation model based on first principles and traditional fouling mechanisms. In order to directly compare the potential benefits of this rotational system, this follow-up study was carried out using A... περισσότερα »
Clinical application of endoscopic ultrasonography for esophageal achalasia.
Clinical application of endoscopic ultrasonography for esophageal achalasia.: [image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles*Clinical application of endoscopic ultrasonography for esophageal achalasia.* Dig Endosc. 2015;27 Suppl 1:11-6 Authors: Minami H, Inoue H, Isomoto H, Urabe S, Nakao K Abstract Endoscopic ultrasonography (EUS) has been widely used for evaluating the nature of diseases of various organs. The possibility of applying EUS for esophageal motility diseases has not been well discussed despite its versatility. At present, peroral endoscopic myotom... περισσότερα »
Determination of the ratio of fluorophore/nanoparticle for fluorescence-labelled nanoparticles
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C5AN02405F, Paper Mario Menendez-Miranda, Jose Manuel Costa-Fernandez, Jorge Ruiz Encinar, Wolfgang J Parak, Carolina Carrillo-Carrion Optical analysis based on fluorescence labeling has been extensively used for the selective tagging of a wide range of biomedical important targets or for sensing purposes. Fluorescent nanoparticles (NPs) offer... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1n28G8X Medicine by Alexandros G.Sfakianakis,An... περισσότερα »
Cross-Sectional Nakagami Images in Passive Stretches Reveal Damage of Injured Muscles
Muscle strain is still awanting a noninvasive quantitatively diagnosis tool. High frequency ultrasound (HFU) improves image resolution for monitoring changes of tissue structures, but the biomechanical factors may influence ultrasonography during injury detection. We aim to illustrate the ultrasonic parameters to present the histological damage of overstretched muscle with the consideration of biomechanical factors. Gastrocnemius muscles from mice were assembled and ex vivo passive stretching was performed before or after injury. After injury, the muscle significantly decreased me... περισσότερα »
Prevalence and Predictors of Self-Medication with Antibiotics in Al Wazarat Health Center, Riyadh City, KSA
Background. Antibiotics are responsible for most dramatic improvement in medical therapy in history. These medications contributed significantly to the decreasing mortality and morbidity when prescribed based on evidence of microbial infection. Objective. The aim of this study was to determine the prevalence and predictors of self-prescription with antibiotics in Al Wazarat Health Center, Riyadh City, Kingdom of Saudi Arabia. Material and Methods. Cross-sectional study was conducted in Al Wazarat Health Center between February 2014 and November 2014. Respondents were randomly selec... περισσότερα »
Outcomes of Various Interventions for First-Time Perianal Abscesses in Children
Introduction. In children treated surgically for first-time perianal abscesses, discovery and excision of concomitant fistulas may also be warranted. Aim. To evaluate children of varying age after incision and drainage of first-time perianal abscesses, examining recurrences rates with and without search for a fistula. Method. A retrospective review was conducted, analyzing children (ages 0–15 years) treated for first-time perianal abscesses at a tertiary pediatric surgical center, with a minimum follow-up of 6 months. Results. A total of 104 patients subjected to 112 treatments fo... περισσότερα »
Neurolinguistics: Structure, Function, and Connectivity in the Bilingual Brain
Advances in neuroimaging techniques and analytic methods have led to a proliferation of studies investigating the impact of bilingualism on the cognitive and brain systems in humans. Lately, these findings have attracted much interest and debate in the field, leading to a number of recent commentaries and reviews. Here, we contribute to the ongoing discussion by compiling and interpreting the plethora of findings that relate to the structural, functional, and connective changes in the brain that ensue from bilingualism. In doing so, we integrate theoretical models and empirical fi... περισσότερα »
Exercise induces peripheral muscle but not cardiac output adaptations after stroke. A randomised controlled pilot trial
Publication date: Available online 4 January 2016 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Sarah A. Moore, Djordje G. Jakovljevic, Gary A. Ford, Lynn Rochester, Michael I. Trenell ObjectiveTo explore the physiological factors influencing exercise-induced changes in peak oxygen consumption and function post-stroke.DesignSingle centre, single-blind, randomised controlled pilot trial.SettingCommunity stroke services, North East England.ParticipantsForty adults (>50 years, independent with/without stick) with stroke (>6 months) were recruited from 117 eligibl... περισσότερα »
Achalasia and epiphrenic diverticulum.
Achalasia and epiphrenic diverticulum.: [image: http:--production.springer.de-OnlineReso] Related Articles*Achalasia and epiphrenic diverticulum.* World J Surg. 2015;39(7):1614-9 Authors: Fisichella PM, Jalilvand A, Dobrowolsky A Abstract Epiphrenic diverticula are a rare disease almost always associated with an underlying motility disorder of the esophagus, such as achalasia. Treatment of any underlying motility disorder must be included in the management of epiphrenic diverticula to prevent postoperative complications and recurrences. Therefore, the goal of this paper is to desc... περισσότερα »
A wearable vibrotactile biofeedback device allowing identification of different floor conditions for lower-limb amputees
Publication date: Available online 4 January 2016 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Anson H.P. Wan, Duo W.C. Wong, Christina Z.H. Ma, Winson C.C. Lee, Ming Zhang ObjectiveTo evaluate a newly developed biofeedback device enabling lower-limb amputees to identify various floor conditions.DesignAn experiment with self-control and group-control: self-control with repeated measures (with and without the biofeedback device) within amputee group; comparison between amputee and non-amputee groups.SettingUniversity locomotion laboratory.ParticipantsFive lowe... περισσότερα »
Smaller amplitude of H-reflex in females with patellofemoral pain: Thinking outside proximal, local and distal factors
Publication date: Available online 4 January 2016 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Danilo de Oliveira Silva, Fernando Henrique Magalhães, Nathálie Clara Souto Faria, Marcella Ferraz Pazzinatto, Deisi Ferrari, Evangelos Pappas, Fábio Mícolis de Azevedo Objective(s)To investigate whether vastus medialis (VM) H-reflexes differ based on the presence or absence of patellofemoral pain (PFP). An additional objective was to assess the capability of VM H-reflex measurements in discriminating accurately between females with and without PFP.DesignCross-secti...περισσότερα »
Use of Anticholinergic Drugs Does Not Increase Risk for Dementia in Parkinson’s Disease Patients
Principal investigator David J. Burn, Director of the Institute of Neuroscience and Professor of Movement Disorder Neurology at Newcastle University, UK, explained, "This is the first study to explore an association between anticholinergic burden and mild cognitive impairment (MCI) in PD participants, and is timely given recent research demonstrating cumulative anticholinergic burden and risk of AD in the general population. Our assessment will help determine whether patients prescribed medication with anticholinergic activity are more likely to develop dementia, and hence allow e... περισσότερα »
Use of Anticholinergic Drugs Does Not Increase Risk for Dementia in Parkinson’s Disease Patients
Principal investigator David J. Burn, Director of the Institute of Neuroscience and Professor of Movement Disorder Neurology at Newcastle University, UK, explained, "This is the first study to explore an association between anticholinergic burden and mild cognitive impairment (MCI) in PD participants, and is timely given recent research demonstrating cumulative anticholinergic burden and risk of AD in the general population. Our assessment will help determine whether patients prescribed medication with anticholinergic activity are more likely to develop dementia, and hence allow e... περισσότερα »
Peroral endoscopic esophageal myotomy for achalasia.
The potential and perspective of peroral endoscopic esophageal myotomy for achalasia.: [image: http:--production.springer.de-OnlineReso] Related Articles*The potential and perspective of peroral endoscopic esophageal myotomy for achalasia.* World J Surg. 2015;39(7):1598-602 Authors: Fuchs KH, Schulz T, Varga G, Babic B, Breithaupt W Abstract The therapeutic spectrum of this disorder consists of medical therapy, endoscopic balloon dilatation, endoscopic Botox injection, open or laparoscopic cardia myotomy, and most recently transesophageal endoscopic myotomy (POEM peroral endoscop... περισσότερα »
Treatment of esophageal achalasia in children
Treatment of esophageal achalasia in children: Today and tomorrow.: [image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles*Treatment of esophageal achalasia in children: Today and tomorrow.* J Pediatr Surg. 2015;50(5):726-30 Authors: Caldaro T, Familiari P, Romeo EF, Gigante G, Marchese M, Contini AC, Federici di Abriola G, Cucchiara S, De Angelis P, Torroni F, Dall'Oglio L, Costamagna G Abstract BACKGROUND: Esophageal achalasia (EA) is a rare esophageal motility disorder in children. Laparoscopic Heller myotomy (LHM) represents the treatment of choice in young patient... περισσότερα »
IJERPH, Vol. 13, Pages 104: Structural Model for the Effects of Environmental Elements on the Psychological Characteristics and Performance of the Employees of Manufacturing Systems
This paper analyzes the effects of environmental elements on the psychological characteristics and performance of employees in manufacturing systems using structural equation modeling. Increasing the comprehension of these effects may help optimize manufacturing systems regarding their employees' psychological characteristics and performance from a macroergonomic perspective. As the method, a new macroergonomic compatibility questionnaire (MCQ) was developed and statistically validated, and 158 respondents at four manufacture companies were considered. Noise, lighting and temperat...περισσότερα »
The allergic and hypersensitivity conditions classification for the ICD-11
Optimization and simplification of the allergic and hypersensitivity conditions classification for the ICD-11: Abstract Background Since 2013, an international collaboration of Allergy Academies, including first the World Allergy Organization (WAO), the American Academy of Allergy Asthma and Immunology (AAAAI) and the European Academy of Allergy and Clinical Immunology (EAACI), and than, the American College of Allergy, Asthma and Immunology (ACAAI), the Latin American Society of Allergy, Asthma and Immunology (SLAAI) and the Asia Pacific Association of Allergy, Asthma and Clinical... περισσότερα »
Gastrostomy insertion techniques in children.
A systematic review and meta-analysis of gastrostomy insertion techniques in children.: [image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles*A systematic review and meta-analysis of gastrostomy insertion techniques in children.* J Pediatr Surg. 2015;50(5):718-25 Authors: Baker L, Beres AL, Baird R Abstract BACKGROUND: Gastrostomy tubes are inserted via multiple techniques to provide a route for enteral feeding in the pediatric population. This review compares the rate of major complications and resource utilization associated with the various insertion techniques. M... περισσότερα »
Gastroesophageal reflux in children with neurologic impairment : Fundoplication and gastrostomy versus percutaneous gastrojejunostomy
Fundoplication and gastrostomy versus percutaneous gastrojejunostomy for gastroesophageal reflux in children with neurologic impairment: A systematic review and meta-analysis.: [image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles*Fundoplication and gastrostomy versus percutaneous gastrojejunostomy for gastroesophageal reflux in children with neurologic impairment: A systematic review and meta-analysis.* J Pediatr Surg. 2015 Authors: Livingston MH, Shawyer AC, Rosenbaum PL, Jones SA, Walton JM Abstract BACKGROUND: Children with neurologic impairment often fail medical... περισσότερα »
Mastication in adults with Down syndrome
Increasing the number of inter-arch contacts improves mastication in adults with Down syndrome: a prospective controlled trial.: [image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles*Increasing the number of inter-arch contacts improves mastication in adults with Down syndrome: a prospective controlled trial.* Physiol Behav. 2015 Jun 1;145:14-21 Authors: Hennequin M, Mazille MN, Cousson PY, Nicolas E Abstract Feeding difficulties due to their condition have been widely described for babies, children and adults with Down syndrome (DS). A previous study demonstrated tha... περισσότερα »
Masitinib in the treatment of mucosal primary esophageal melanoma
Rapid and clinically significant response to masitinib in the treatment of mucosal primary esophageal melanoma with somatic KIT exon 11 mutation involving brain metastases: A case report.: *Rapid and clinically significant response to masitinib in the treatment of mucosal primary esophageal melanoma with somatic KIT exon 11 mutation involving brain metastases: A case report.* Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Dec;159(4):695-7 Authors: Prosvicova J, Lukesova S, Kopecky J, Grim J, Papik Z, Kolarova R, Navratilova B, Dubreuil P, Agopian J, Mansfield C, Moussy A... περισσότερα »
Oropharyngeal symptoms for abnormal swallowing in patients with OSAS
Subjective oropharyngeal symptoms for abnormal swallowing in Japanese patients with obstructive sleep apnea syndrome: a descriptive questionnaire study.: *Subjective oropharyngeal symptoms for abnormal swallowing in Japanese patients with obstructive sleep apnea syndrome: a descriptive questionnaire study.* Cranio. 2016 Jan 2;:1-5 Authors: Kato T, Abe K, Mikami A, Sugita H, Muraki H, Okura M, Ohi M, Taniguchi M Abstract OBJECTIVES: This study aimed to investigate the prevalence of clinical symptoms related to abnormal swallowing in a large sample of obstructive sleep apnea syndr...περισσότερα »
Swallowing-Related Pulmonary Complications
Identifying the Risk of Swallowing-Related Pulmonary Complications in Older Patients With Hip Fracture.: *Identifying the Risk of Swallowing-Related Pulmonary Complications in Older Patients With Hip Fracture.* Orthopedics. 2015 Dec 31;:1-5 Authors: Meals C, Roy S, Medvedev G, Wallace M, Neviaser RJ, O'Brien J Abstract To identify and potentially modify the risk of pulmonary complications in a group of older patients with hip fracture, the authors obtained speech and language pathology consultations for these patients. Then they performed a retrospective chart review of all patien... περισσότερα »
Diseases of the Esophagus
Aspirin prevents atrophy of esophageal nitrergic myenteric neurons in a mouse model of chronic Chagas disease The consequences of using aspirin (ASA) for the pathogenesis of Chagas disease are unclear. This study evaluated the effects of treatment of Chagas disease with ASA on the esophageal nitrergic myenteric neuron population and esophageal wall in mice. We observed that treatment of chagasic infection with ASA protects the esophageal myenteric neurons from the atrophy caused by the Trypanosoma cruzi infection. The mice were infected with 1300 trypomastigotes of Y strain T. cruzi ... περισσότερα »
Craniomaxillofacial Trauma
Meta Analysis of Etiology and its Clinical and Radiological Correlation in Cases of Craniomaxillofacial Trauma: Abstract AimThe present study was planned to investigate the etiology of injuries and to analyze correlation between clinical and radiological findings in cases of craniomaxillofacial trauma. Study DesignAn 18 months cross-sectional study was done and 325 patients with maxillofacial fractures were analyzed from January 2013 to June 2014 who reported to the department of oral and maxillofacial surgery, Aligarh, Uttar Pradesh. Data was recorded in a preformed case sheet ... περισσότερα »
Long-Term Changes in Drug Craving and Nutritional Status of Opioid Addicts with Nucleus Accumbens Ablative Stereotactic Neurosurgery at Five Years Postoperatively
*Background:* The nucleus accumbens (NAcc) has been proven to be associated with drug and food craving. NAcc ablative neurosurgery has been suggested to modulate the balance of the brain reward system and thus alleviate drug dependence in patients. It has been hypothesized that it would also alleviate food craving in patients as well as altering their nutritional status. *Aims:* This study aimed to estimate the effect of NAcc neurosurgery on drug craving and nutritional status in patients with drug dependence at 5 years postoperatively. *Methods:* The study included 100 patients wit... περισσότερα »
Observational study of prolonged times to tracheal extubation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
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Extracranial contamination in the INVOS 5100C versus the FORE-SIGHT ELITE cerebral oximeter: a prospective observational crossover study in volunteers
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
Abstract Purpose Previous studies have found that most cerebral oximeters are subject to inaccuracies secondary to extracranial contamination of the cerebral oximetric signals. We hypothesized that the more advanced second-generation FORE-SIGHT ELITE cerebral oximeter would be significantly less affected by extracranial tissue hypoxemia than the more widely used first-generation INVOS™ 5100C monitor. Methods Twenty healthy […]
Complementary and alternative medicine in anesthesia: Are we really going there?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
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The prescription opioid epidemic: a call to action for our profession
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
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Mismanagement of obstructive sleep apnea may result in finding these patients dead in bed
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
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Perioperative management of patients with obstructive sleep apnea: a survey of Canadian anesthesiologists
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
Abstract Introduction Obstructive sleep apnea (OSA) may increase the incidence of postoperative complications when undiagnosed. The purpose of this study was to evaluate the perspectives of Canadian anesthesiologists regarding the perioperative management of patients with diagnosed or suspected OSA. Methods This study was conducted as a survey of Canadian anesthesiologists using a self-administered scenario-based questionnaire. […]
The prescription opioid epidemic: an overview for anesthesiologists
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
Abstract Purpose The objectives for preparing this article were to review the historical context and epidemiology surrounding the North American prescription opioid crisis, to summarize the evidence regarding the benefits and harms of long-term opioid therapy for non-cancer pain, and to outline ways in which anesthesiologists may help ameliorate the problem. Source We searched PubMed, […]
Long-Term Changes in Drug Craving and Nutritional Status of Opioid Addicts with Nucleus Accumbens Ablative Stereotactic Neurosurgery at Five Years Postoperatively
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
Background: The nucleus accumbens (NAcc) has been proven to be associated with drug and food craving. NAcc ablative neurosurgery has been suggested to modulate the balance of the brain reward system and thus alleviate drug dependence in patients. It has been hypothesized that it would also alleviate food craving in patients as well as altering […]
Consensus Guidelines for High Grade Gastro-Entero-Pancreatic (GEP) Neuroendocrine Tumours and Neuroendocrine Carcinomas (NEC)
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
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Consensus Guidelines for Neuroendocrine Neoplasms of the Appendix (Excluding Goblet Cell Carcinomas)
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
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Orbital floor fractures – short- and intermediate-term complications depending on treatment procedures
Orbital floor fractures – short- and intermediate-term complications depending on treatment procedures: Background: Many reconstruction materials for orbital floor fractures have been described in the past including autologous bone transplants, resorbable polymers and titan meshes. So far evidence is missing which material is used successfully regarding indication and particular size of defect. Therefore the aim of this study was to evaluate which reconstruction technique produces best clinical outcome and least complications associated with indication. Methods: Retrospectively, sur... περισσότερα »
Voice
*>* *elect item 267269* - *Select item 26725548**3.* *J Voice. 2015 Dec 22. pii: S0892-1997(15)00258-1. doi: 10.1016/j.jvoice.2015.11.007. [Epub ahead of print]* *Effect of Two Isolated Vocal-facilitating Techniques Chant Talk and Pitch Inflections on the Phonation of Female* Speech-language Pathology Students: A Pilot Study. *Meerschman I1, Bettens K2, Dejagere S2, Tetaert L2, D'haeseleer E2, Claeys S3, Van Lierde K2.* Author information Abstract OBJECTIVE: *The purpose of this study was to determine the effect of the isolated vocal-facilitating techniques Chant Talk and Pitch... περισσότερα »
Screening : NY-ESO-1 autoantibody as a tumor-specific biomarker for esophageal cancer
NY-ESO-1 autoantibody as a tumor-specific biomarker for esophageal cancer: screening in 1969 patients with various cancers: Abstract BackgroundAlthough serum NY-ESO-1 antibodies (s-NY-ESO-1-Abs) have been reported in patients with esophageal carcinoma, this assay system has not been used to study a large series of patients with various other cancers. Patients and methodsSerum samples of 1969 cancer patients [esophageal cancer (*n* = 172), lung cancer (*n* = 269), hepatocellular carcinoma (*n* = 91), prostate cancer (*n* = 358), gastric cancer (*n* = 313), colorectal cancer ( *n* ...περισσότερα »
Diagnosis and Therapy of Patients With Functional Dysphonia
Encouragement to Increase the Use of Psychosocial Skills in the Diagnosis and Therapy of Patients With Functional Dysphonia Publication date: Available online 5 January 2016 *Source:*Journal of Voice Author(s): Jürg Kollbrunner, Eberhard Seifert Clinicians believe that psychosocial factors play a causal role in the etiology of many forms of functional dysphonia (FD). But for decades, all attempts to confirm such causation have failed. This paper aims to show the logic of this failure, to discuss the possibilities of employing psychology in therapy nonetheless, and to encourage clinic... περισσότερα »
Vocal Cool-down Exercises
The Impact of Vocal Cool-down Exercises: A Subjective Study of Singers' and Listeners' Perceptions Publication date: Available online 5 January 2016 *Source:*Journal of Voice Author(s): Kari Ragan Objective Using subjective measures, this study investigated singers' and listeners' perceptions of changes in voice condition after vocal cool-down exercises. Study Design A single-subject crossover was designed to evaluate whether there were discernible differences in either singer or listener perceptions from pre (no vocal cool downs) to post (with cool downs) test. Subjective questionn... περισσότερα »
Intrasubject Reliability of Maximum Phonation Time
Intrasubject Reliability of Maximum Phonation Time Publication date: Available online 5 January 2016 *Source:*Journal of Voice Author(s): Aaron M. Johnson, Alicia Goldfine Objectives/Hypothesis The primary objectives of this study were to determine the intrasubject reliability of repeated measures of maximum phonation time (MPT) duration during a single session and to examine the effects of age, sex, and total phonatory airflow on this reliability. Study Design This study used repeated measures. Methods Duration and total phonatory airflow during three consecutive MPT trials were co...περισσότερα »
The Angular Velocity Between the Vocal Folds During Throat Clearing
A Detailed Motion Analysis of the Angular Velocity Between the Vocal Folds During Throat Clearing Using High-speed Digital Imaging Publication date: Available online 5 January 2016 *Source:*Journal of Voice Author(s): Toshihiko Iwahashi, Makoto Ogawa, Kiyohito Hosokawa, Chieri Kato, Hidenori Inohara Objectives To assess the angular velocity between the vocal folds just before the compression phase of throat clearing (TC) using high-speed digital imaging (HSDI) of the larynx. Methods Twenty normal healthy adults (13 males and seven females) were enrolled in the study. Each participant...περισσότερα »
Head Position and/or Stance on the Self-perception of Phonatory Effort
The Effect of via Voice Publication date: Available online 5 January 2016 *Source:*Journal of Voice Author(s): Marina Gilman, Michael M. Johns BackgroundVocal fatigue is a common but poorly defined complaint of patients presenting with voice disorders. Definitions of vocal fatigue generally include increased self-perceived phonatory effort resulting from references to vocal loading or prolonged voice use resulting in deterioration of function. The present study looks at the role of posture, specifically head position and stance, in self-perceived phonatory effort.MethodsForty-six hea... περισσότερα »
Real-time computer-based visual feedback improves visual acuity in downbeat nystagmus – a pilot study
Real-time computer-based visual feedback improves visual acuity in downbeat nystagmus Abstract Background Patients with downbeat nystagmus syndrome suffer from oscillopsia, which leads to an unstable visual perception and therefore impaired visual acuity. The aim of this study was to use real-time computer-based visual feedback to compensate for the destabilizing slow phase eye movements. Methods The patients were sitting in front of a computer screen with the head fixed on a chin rest. The eye movements were recorded by an eye tracking system (EyeSeeCam®). We tested the v...περισσότερα »
Mean platelet volume and red cell distribution width in inflammation
A review of the association of mean platelet volume and red cell distribution width in inflammation: 2016-01-05T04-46-14Z *Source:* International Journal of Research in Medical Sciences Mujgan Gurler, Gulali Aktas. Simple hemogram parameters have been proposed as novel markers of inflammation recently. Two of these parameters are red cell distribution width (RDW) and mean platelet volume (MPV). Both MPV and RDW have been shown to be associated with inflammatory diseases. In this review, we aimed to discuss the clinical significance of these hemogram parameters in inflammatory stat...περισσότερα »
Post-traumatic Pott's puffy tumour
: A case report via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 4 January 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): P. Clarós, H. Ahmed, A. Clarós IntroductionOsteomyelitis of the frontal sinus is a rare clinical entity and generally occurs as a complication of trauma to the forehead or frontal sinusitis. It can be responsible for life-threatening complications, as the first symptoms may appear to be minor. Early diagnosis and appropriate management to prevent central nervous system compl...περισσότερα »
Tracheal rhinoscleroma
Tracheal rhinoscleroma via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 4 January 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): A. Bigi, M. Bartolomeo, V. Costes, M. Makeieff IntroductionTracheal rhinoscleroma is an infectious granulomatosis of the tracheobronchial tract caused by a Gram-negative bacillus. Exclusively tracheal involvement has been rarely reported in the literature. The purpose of this study was to report a case of subglottic stenosis secondary to rhinoscleroma.SummaryA 46-year... περισσότερα »
Strontium effects on root dentin tubule occlusion and nanomechanical properties
Publication date: Available online 5 January 2016 *Source:*Dental Materials Author(s): Kuniko Saeki, Grayson W. Marshall, Stuart A. Gansky, Charles R. Parkinson, Sally J. Marshall ObjectivesDentin hypersensitivity often is treated by promotion of dentin tubule occlusion. In this in vitro study we evaluated nanomechanical properties and degree of tubule occlusion conferred to sound and demineralized human root dentin following treatment with a 10% (w/w) strontium acetate solution and its relation to the treatment duration and delivery method.Methods24 human cervical root dentin disks... περισσότερα »
Effect of carboidiimide on thermal denaturation temperature of dentin collagen
Publication date: Available online 5 January 2016 *Source:*Dental Materials Author(s): Milena Cadenaro, Luca Fontanive, Chiara Ottavia Navarra, Pietro Gobbi, Annalisa Mazzoni, Roberto Di Lenarda, Franklin R. Tay, David H. Pashley, Lorenzo Breschi Objectives1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) has been shown to cross-link dentin type I collagen. Increased cross-linking usually elevates the glass transition temperature of polymers. The aim of this study was to evaluate the cross-linking reaction promoted by EDC in different aqueous concentrations by measu... περισσότερα »
Survival of resin infiltrated ceramics under influence of fatigue
Publication date: Available online 4 January 2016 *Source:*Dental Materials Author(s): Moustafa N. Aboushelib, Mohamed H. Elsafi Purposeto evaluate influence of cyclic fatigue on two resin infiltrated ceramics and three all-ceramic crowns manufactured using CAD/CAM technology.Materials and methodsCAD/CAM anatomically shaped crowns were manufactured using two resin infiltrated ceramics (Lava Ultimate and Vita Enamic), two reinforced glass ceramic milling blocks (IPSEmpress CAD and IPSe.max CAD) and a veneered zirconia core (IPSZir CAD). IPSe.max CAD and IPSZir CAD were milled into 0.... περισσότερα »
Characterization of methacrylate-based composites containing thio-urethane oligomers
Publication date: Available online 4 January 2016 *Source:*Dental Materials Author(s): Atais Bacchi, Morgan Nelson, Carmem S. Pfeifer ObjectiveTo evaluate the ability of thio-urethane oligomers to improve the properties of restorative composite resins.MethodsOligomers were synthesized by combining 1,6-hexanediol-diissocyante (aliphatic) with pentaerythritol tetra-3-mercaptopropionate (PETMP) or 1,3-bis(1-isocyanato-1-methylethyl)benzene (aromatic) with trimethylol-tris-3-mercaptopropionate (TMP), at 1:2 isocyanate:thiol, leaving pendant thiols. Oligomers were added at 0–20wt% to Bis... περισσότερα »
The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin
[image: cr20161f1th.jpg] *The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin* Cell Research advance online publication, January 5 2016. doi:10.1038/cr.2016.1 Authors: Susanne V Schmidt, Wolfgang Krebs, Thomas Ulas, Jia Xue, Kevin Baßler, Patrick Günther, Anna-Lena Hardt, Hartmut Schultze, Jil Sander, Kathrin Klee, Heidi Theis, Michael Kraut, Marc Beyer & Joachim L Schultze [image: 1PHUJGq] from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1myoYX6 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis v... περισσότερα »
Blind boy learns to ‘see’ with technique used by BATS: Ruben, 8, clicks his … – Daily Mail
[image: 1R8XJPy] Daily Mail *Blind boy learns to 'see' with technique used by BATS: Ruben, 8, clicks his …* *Daily Mail* Mr Kish has been practising echolocation since he was a child, after being blinded at just 13 months old by an aggressive form of eye *cancer* – and his talent has earnt him the nickname Batman. He has helped hundreds of blind people worldwide live more … from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1VEEyfq via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PHYFar via IFTTT
E3 Ubiquitin Ligases as Molecular Targets in Human Oral Cancers
E3 Ubiquitin Ligases as Molecular Targets in Human Oral Cancers: The ubiquitin-proteasome pathway is involved in various biological processes. Several oncogenic E3 ligases target tumor suppressor proteins for ubiquitin-mediated degradation. Alternatively, some other E3 ligases play as a tumor suppressor specifically targeting oncogene products. Deregulation of these E3 ligases induces unbalance between oncogenic signal and tumor suppressor pathway and leads to cellular transformation, tumor growth and metastasis in various human malignancies including oral, and head and neck cancers...περισσότερα »
Delayed meat allergy
Two galactose-α-1,3-galactose carrying peptidases from pork kidney mediate anaphylactogenic responses in delayed meat allergy: [image: cover.gif?v=1&s=51729ab99aa778a4e7e44069] Abstract Background Serum IgE-antibodies directed at galactose-α-1,3-galactose (α-Gal) are associated with a novel form of delayed anaphylaxis occuring upon consumption of red meat or innards. Pork kidney is known as the most potent trigger of this syndrome, but the culprit allergens have not yet been identified. The aim of this study was the identification and characterization of pork kidney proteins med... περισσότερα »
The allergic and hypersensitivity conditions classification for the ICD-11
Optimization and simplification of the allergic and hypersensitivity conditions classification for the ICD-11: Abstract Background Since 2013, an international collaboration of Allergy Academies, including first the World Allergy Organization (WAO), the American Academy of Allergy Asthma and Immunology (AAAAI) and the European Academy of Allergy and Clinical Immunology (EAACI), and than, the American College of Allergy, Asthma and Immunology (ACAAI), the Latin American Society of Allergy, Asthma and Immunology (SLAAI) and the Asia Pacific Association of Allergy, Asthma and Clinical... περισσότερα »
Neurolinguistics: Structure, Function, and Connectivity in the Bilingual Brain
Neurolinguistics: Structure, Function, and Connectivity in the Bilingual Brain: Advances in neuroimaging techniques and analytic methods have led to a proliferation of studies investigating the impact of bilingualism on the cognitive and brain systems in humans. Lately, these findings have attracted much interest and debate in the field, leading to a number of recent commentaries and reviews. Here, we contribute to the ongoing discussion by compiling and interpreting the plethora of findings that relate to the structural, functional, and connective changes in the brain that ensue fr... περισσότερα »
Prevalence and Predictors of Self-Medication with Antibiotics
Prevalence and Predictors of Self-Medication with Antibiotics in Al Wazarat Health Center, Riyadh City, KSA: Background. Antibiotics are responsible for most dramatic improvement in medical therapy in history. These medications contributed significantly to the decreasing mortality and morbidity when prescribed based on evidence of microbial infection. Objective. The aim of this study was to determine the prevalence and predictors of self-prescription with antibiotics in Al Wazarat Health Center, Riyadh City, Kingdom of Saudi Arabia. Material and Methods. Cross-sectional study was co... περισσότερα »
Immunonkologische Therapiestrategien
Immunonkologische Therapiestrategien: Zusammenfassung HintergrundDas Immunsystem ist prinzipiell in der Lage, Tumorzellen zu erkennen und zu eliminieren. Manche Tumorzellen induzieren über Mechanismen des „immunoediting“ und der „immune evasion“ eine Immuntoleranz und können so der Immunüberwachung entkommen. Grundgedanke der Immunonkologie ist es, das körpereigene Abwehrsystem wieder in die Lage zu versetzen, diese entarteten Zellen anzugreifen. Die klinische Bedeutung von T-Zellen bei der Kontrolle von Tumorerkrankungen ist heute unbestritten. Die Natur der Antigene, die dem Imm... περισσότερα »
Sexual harassment and inappropriate behavior in jūdō coaches and instructors
The 'jūdō sukebei' phenomenon: when crossing the line merits more than shidō [“minor infringement”] ―Sexual harassment and inappropriate behavior in jūdō coaches and instructors: The sport of jūdō was intended as an activity “for all”. Since in 1996 a major sex abuse scandal broke out that involved a Dutch top jūdō coach and several female elite athletes, international media have identified many more abuses. To date no scholarly studies exist that have examined the nature, extent, and consequences of these anomalies. We intend in this paper to review and analyze sexual abuses in jūd...περισσότερα »
Acacia gum improves the gut barrier functionality
Acacia gum improves the gut barrier functionality in vitro: The Leaky Gut Syndrome - impairment of the gut wall functionality - is involved in many inflammatory diseases, among them IBS. The aim of this work was to evaluate the effect of arabinogalactan (AG) and fructo-oligosaccharides (FOS) on gut wall modulation using a Simulator of the Human Intestinal Microbial Ecosystem (SHIME(R)) inoculated with faecal material from an IBS donor-coupled with co-cultures of enterocytes and macrophages (transwell approach using Caco-2 and THP1 cells). AG and FOS showed a different fermentation p...περισσότερα »
Sensors, Vol. 16, Pages 60: Estimation of Gaze Detection Accuracy Using the Calibration Information-Based Fuzzy System
Gaze tracking is a camera-vision based technology for identifying the location where a user is looking. In general, a calibration process is applied at the initial stage of most gaze tracking systems. This process is necessary to calibrate for the differences in the eyeballs and cornea size of the user, as well as the angle kappa, and to find the relationship between the user's eye and screen coordinates. It is applied on the basis of the information of the user's pupil and corneal specular reflection obtained while the user is looking at several predetermined positions on a scree... περισσότερα »
Nutrients, Vol. 8, Pages 21: Effects of Dietary Protein and Fiber at Breakfast on Appetite, ad Libitum Energy Intake at Lunch, and Neural Responses to Visual Food Stimuli in Overweight Adults
Increasing either protein or fiber at mealtimes has relatively modest effects on ingestive behavior. Whether protein and fiber have additive or interactive effects on ingestive behavior is not known. Fifteen overweight adults (5 female, 10 male; BMI: 27.1 ± 0.2 kg/m2; aged 26 ± 1 year) consumed four breakfast meals in a randomized crossover manner (normal protein (12 g) + normal fiber (2 g), normal protein (12 g) + high fiber (8 g), high protein (25 g) + normal fiber (2 g), high protein (25 g) + high fiber (8 g)). The amount of protein and fiber consumed at breakfast did not influ... περισσότερα »
Nutrients, Vol. 8, Pages 27: Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy
Emerging evidence suggested mitophagy activation mitigates ethanol-induced liver injury. However, the effect of ethanol on mitophagy is inconsistent. Importantly, the understanding of mitophagy status after chronic ethanol consumption is limited. This study evaluated the effect of quercetin, a naturally-occurring flavonoid, on chronic ethanol-induced mitochondrial damage focused on mitophagy. An ethanol regime to mice for 15 weeks (accounting for 30% of total calories) led to significant mitochondrial damage as evidenced by changes of the mitochondrial ultrastructure, loss of mito... περισσότερα »
Sustainability, Vol. 8, Pages 44: The Effects of Ambient Water Quality and Eurasian Watermilfoil on Lakefront Property Values in the Coeur d’Alene Area of Northern Idaho, USA
Amenity value of water resources has become a major driving force of recent population growth in the region centered on Coeur d'Alene Lake in northern Idaho, USA. Despite regulatory measures aimed to protect lake water quality, surface water quality is increasingly threatened by lakefront development and invasions of Eurasian watermilfoil (Myriophyllum spicatum), a non-indigenous aquatic plant species. We used hedonic modeling to estimate the effects of ambient water quality and the presence of Eurasian watermilfoil on lakefront property values of single-family homes in the Coeur ... περισσότερα »
Sustainability, Vol. 8, Pages 45: Multi-Layered Capital Subsidy Policy for the PV Industry in China Considering Regional Differences
As a country with huge energy consumption, China has been paying more and more attention to green growth in recent years. Several subsidy policies have been conducted to boost the photovoltaic (PV) industry so far. However, as a matter of fact, there are 31 provinces and municipalities (PM) in mainland China, and the economic condition, environmental resources and energy structure of each PM are all significantly different, which leads to a discrepancy of PV efficiency among regions. This paper proposes that the subsidies for the PV industry should be considered mainly from three ...περισσότερα »
Sensors, Vol. 16, Pages 59: A Deadline-Aware Scheduling and Forwarding Scheme in Wireless Sensor Networks
Many applications in wireless sensor networks (WSNs) require energy consumption to be minimized and the data delivered to the sink within a specific delay. A usual solution for reducing energy consumption is duty cycling, in which nodes periodically switch between sleep and active states. By increasing the duty cycle interval, consumed energy can be reduced more. However, a large duty cycle interval causes a long end-to-end (E2E) packet delay. As a result, the requirement of a specific delay bound for packet delivery may not be satisfied. In this paper, we aim at maximizing the du... περισσότερα »
Sensors, Vol. 16, Pages 62: Pedestrian Counting with Occlusion Handling Using Stereo Thermal Cameras
The number of pedestrians walking the streets or gathered in public spaces is a valuable piece of information for shop owners, city governments, event organizers and many others. However, automatic counting that takes place day and night is challenging due to changing lighting conditions and the complexity of scenes with many people occluding one another. To address these challenges, this paper introduces the use of a stereo thermal camera setup for pedestrian counting. We investigate the reconstruction of 3D points in a pedestrian street with two thermal cameras and propose an al...περισσότερα »
Nutrients, Vol. 8, Pages 26: Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats
Plasma concentrations of metabolites along the choline oxidation pathway have been linked to increased risk of major lifestyle diseases, and peroxisome proliferator-activated receptors (PPARs) have been suggested to be involved in the regulation of key enzymes along this pathway. In this study, we investigated the effect of PPAR activation on circulating and urinary one-carbon metabolites as well as markers of B-vitamin status. Male Wistar rats (n = 20) received for 50 weeks either a high-fat control diet or a high-fat diet with tetradecylthioacetic acid (TTA), a modified fatty ac... περισσότερα »
Sensors, Vol. 16, Pages 58: Characterizations and Electrical Modelling of Sensory Samples Formed from Synthesized Vanadium (V) Oxide and Copper Oxide Graphene Quantum Tunneling Composites (GQTC) Applied in Electrotribology
CuO and V2O5 graphene quantum tunneling composites (GQTC) presented in this article were produced and their sensory properties were analyzed. The composites were synthesised using two stage high-power milling process, which resulted in materials that have good temeprature and pressure sensory properties. Described production process defines internal structure of materials such that when used as sensor in the desired range, it exhibits a strong percolation effect. The experiment, with controlled changing physical conditions during electrotribological measurement, enabled analyzing ...περισσότερα »
Agronomy, Vol. 6, Pages 3: Weed Control with Cover Crops in Irrigated Potatoes
Field experiments at Oakes, ND, USA in 2010 and Carrington, ND, USA in 2011 were conducted to evaluate the potential for cover crops grown in the Northern Great Plains, USA in order to reduce weed emergence and density in irrigated potatoes. Treatments included five cover crop treatments and three cover crop termination treatments. Termination of cover crops was done with glyphosate, disk-till, and roto-till. Cover crop biomass accumulation was greatest for rye/canola and triticale at Oakes, and hairy vetch and hairy vetch/rye at Carrington. Cover crop and termination affected wee... περισσότερα »
Climate, Vol. 4, Pages 4: Impact of Irrigation Method on Water Use Efficiency and Productivity of Fodder Crops in Nepal
Improved irrigation use efficiency is an important tool for intensifying and diversifying agriculture in Nepal, resulting in higher economic yield from irrigated farmlands with a minimum input of water. Research was conducted to evaluate the effect of irrigation method (furrow vs. drip) on the productivity of nutritious fodder species during off-monsoon dry periods in different elevation zones of central Nepal. A split-block factorial design was used. The factors considered were treatment location, fodder crop, and irrigation method. Commonly used local agronomical practices were ... περισσότερα »
Nutrients, Vol. 8, Pages 17: Polyphenols and Glycemic Control
Growing evidence from animal studies supports the anti-diabetic properties of some dietary polyphenols, suggesting that dietary polyphenols could be one dietary therapy for the prevention and management of Type 2 diabetes. This review aims to address the potential mechanisms of action of dietary polyphenols in the regulation of glucose homeostasis and insulin sensitivity based on in vitro and in vivo studies, and to provide a comprehensive overview of the anti-diabetic effects of commonly consumed dietary polyphenols including polyphenol-rich mixed diets, tea and coffee, chocolate... περισσότερα »
Nutrients, Vol. 8, Pages 36: Vitamin D Dietary Intake Questionnaire Validation Conducted among Young Polish Women
Due to inadequate intake of Vitamin D, identification of individuals characterised by the highest risk of deficiencies is one of the more crucial tasks for public health. The aim of the presented study was to assess the validity and reproducibility of the designed Vitamin D dietary intake questionnaire based on food frequency assessment—VIDEO-FFQ (VItamin D Estimation Only—Food Frequency Questionnaire) in a group of Polish women aged 20–30 years. Seventy-five participants kept a three-day dietary record and filled out the VIDEO-FFQ twice (immediately after the three-day dietary re... περισσότερα »
Pharmaceutics, Vol. 8, Pages 1: Introduction to Special Issue: A New Paradigm of Gene Therapy
Gene therapy is defined as introducing genetic information for therapeutic purposes. [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1Sx1A8o Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Climate, Vol. 4, Pages 3: Greenhouse Gas Induced Changes in the Seasonal Cycle of the Amazon Basin in Coupled Climate-Vegetation Regional Model
Previous work suggests that changes in seasonality could lead to a 70% reduction in the extent of the Amazon rainforest. The primary cause of the dieback of the rainforest is a lengthening of the dry season due to a weakening of the large-scale tropical circulation. Here we examine these changes in the seasonal cycle. Under present day conditions the Amazon climate is characterized by a zonal separation of the dominance of the annual and semi-annual seasonal cycles. This behavior is strongly modified under greenhouse warming conditions, with the annual cycle becoming dominant thro...περισσότερα »
Phenotyping Exercise Limitation in Systemic Sclerosis: The Use of Cardiopulmonary Exercise Testing
*Background:* Exercise impairment is a common symptom of systemic sclerosis (SSc), a disorder which is frequently complicated by cardiopulmonary involvement. *Objectives:* This study's aims were: (a) to define the prevalence and the potential causes of limited exercise capacity and (b) to study potential differences in clinical, radiological and functional characteristics and blood serology among SSc patients with exercise limitation of different etiology. *Methods:* Prospectively collected data on SSc patients who had conducted full lung function testing, blood serology, thorax hig...περισσότερα »
Remote Sensing, Vol. 8, Pages 33: Determining Subcanopy Psidium cattleianum Invasion in Hawaiian Forests Using Imaging Spectroscopy
High-resolution airborne imaging spectroscopy represents a promising avenue for mapping the spread of invasive tree species through native forests, but for this technology to be useful to forest managers there are two main technical challenges that must be addressed: (1) mapping a single focal species amongst a diverse array of other tree species; and (2) detecting early outbreaks of invasive plant species that are often hidden beneath the forest canopy. To address these challenges, we investigated the performance of two single-class classification frameworks—Biased Support Vector ...περισσότερα »
Remote Sensing, Vol. 8, Pages 39: Airborne Thermal Imagery to Detect the Seasonal Evolution of Crop Water Status in Peach, Nectarine and Saturn Peach Orchards
In the current scenario of worldwide limited water supplies, conserving water is a major concern in agricultural areas. Characterizing within-orchard spatial heterogeneity in water requirements would assist in improving irrigation water use efficiency and conserve water. The crop water stress index (CWSI) has been successfully used as a crop water status indicator in several fruit tree species. In this study, the CWSI was developed in three Prunus persica L. cultivars at different phenological stages of the 2012 to 2014 growing seasons, using canopy temperature measurements of wel... περισσότερα »
Remote Sensing, Vol. 8, Pages 31: Cloud and Snow Discrimination for CCD Images of HJ-1A/B Constellation Based on Spectral Signature and Spatio-Temporal Context
It is highly desirable to accurately detect the clouds in satellite images before any kind of applications. However, clouds and snow discrimination in remote sensing images is a challenging task because of their similar spectral signature. The shortwave infrared (SWIR, e.g., Landsat TM 1.55–1.75 µm band) band is widely used for the separation of cloud and snow. However, for some sensors such as the CBERS-2 (China-Brazil Earth Resources Satellite), CBERS-4 and HJ-1A/B (HuanJing (HJ), which means environment in Chinese) that are designed without SWIR band, such methods are no longer...περισσότερα »
Mutation update and uncommon phenotypes in a French cohort of 96 patients with WFS1-related disorders.
[image: http:--media.wiley.com-assets-7315-19-Wi]Related Articles *Mutation update and uncommon phenotypes in a French cohort of 96 patients with WFS1-related disorders.* Clin Genet. 2015 May;87(5):430-9 Authors: Chaussenot A, Rouzier C, Quere M, Plutino M, Ait-El-Mkadem S, Bannwarth S, Barth M, Dollfus H, Charles P, Nicolino M, Chabrol B, Vialettes B, Paquis-Flucklinger V Abstract WFS1 mutations are responsible for Wolfram syndrome (WS) characterized by juvenile-onset diabetes mellitus and optic atrophy, and for low-frequency sensorineural hearing loss (LFSNHL). Our aim was to ana... περισσότερα »
Comparison of temporal and stride characteristics in myotonic dystrophies type 1 and 2 during dual-task walking
Publication date: February 2016 *Source:*Gait & Posture, Volume 44 Author(s): S. Radovanović, S. Perić, D. Savić-Pavićević, V. Dobričić, J. Pešović, V. Kostić, V. Rakočević-Stojanović ObjectiveWe analyzed temporal and stride characteristics in patients with myotonic dystrophy type 1 (DM1) and type 2 (DM2) while performing dual mental and motor tasks, and investigated correlations between gait parameters and cognitive impairments.MethodDual-task walking was performed by 37 patients (20 DM1 and 17 DM2) and 48 healthy subjects divided into two groups, age- and gender-matched control grou... περισσότερα »
Comparison of temporal and stride characteristics in myotonic dystrophies type 1 and 2 during dual-task walking
Publication date: February 2016 *Source:*Gait & Posture, Volume 44 Author(s): S. Radovanović, S. Perić, D. Savić-Pavićević, V. Dobričić, J. Pešović, V. Kostić, V. Rakočević-Stojanović ObjectiveWe analyzed temporal and stride characteristics in patients with myotonic dystrophy type 1 (DM1) and type 2 (DM2) while performing dual mental and motor tasks, and investigated correlations between gait parameters and cognitive impairments.MethodDual-task walking was performed by 37 patients (20 DM1 and 17 DM2) and 48 healthy subjects divided into two groups, age- and gender-matched control grou... περισσότερα »
Comparison of temporal and stride characteristics in myotonic dystrophies type 1 and 2 during dual-task walking
Publication date: February 2016 *Source:*Gait & Posture, Volume 44 Author(s): S. Radovanović, S. Perić, D. Savić-Pavićević, V. Dobričić, J. Pešović, V. Kostić, V. Rakočević-Stojanović ObjectiveWe analyzed temporal and stride characteristics in patients with myotonic dystrophy type 1 (DM1) and type 2 (DM2) while performing dual mental and motor tasks, and investigated correlations between gait parameters and cognitive impairments.MethodDual-task walking was performed by 37 patients (20 DM1 and 17 DM2) and 48 healthy subjects divided into two groups, age- and gender-matched control grou... περισσότερα »
Pneumocephalus Following Combined Spinoepidural Anesthesia
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
Pneumocephalus Following Combined Spinoepidural Anesthesia: A Case Report: 2016-01-05T06-00-16Z *Source:* Medicine Science | International Medical Journal Emine Karaman, Duygu Kara, Ozgur Ozmen, Zakir Arslan. Various complications may develop as a result of epidural anaesthesia. Pneumocephalus is a rare complication during epidural catheter insertion. In this case report, 61 years old patient was admitted for hip fracture and planned to have hip replacement surgery. Combined spinoepidural anesthesia was planned during surgery as anesthetic tehchnique. Epidural catheter was inserte...περισσότερα »
Exercise induces peripheral muscle but not cardiac output adaptations after stroke. A randomised controlled pilot trial
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Publication date: Available online 4 January 2016 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Sarah A. Moore, Djordje G. Jakovljevic, Gary A. Ford, Lynn Rochester, Michael I. Trenell ObjectiveTo explore the physiological factors influencing exercise-induced changes in peak oxygen consumption and function post-stroke.DesignSingle centre, single-blind, randomised controlled pilot trial.SettingCommunity stroke services, North East England.ParticipantsForty adults (>50 years, independent with/without stick) with stroke (>6 months) were recruited from 117 eligibl... περισσότερα »
A wearable vibrotactile biofeedback device allowing identification of different floor conditions for lower-limb amputees
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Publication date: Available online 4 January 2016 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Anson H.P. Wan, Duo W.C. Wong, Christina Z.H. Ma, Winson C.C. Lee, Ming Zhang ObjectiveTo evaluate a newly developed biofeedback device enabling lower-limb amputees to identify various floor conditions.DesignAn experiment with self-control and group-control: self-control with repeated measures (with and without the biofeedback device) within amputee group; comparison between amputee and non-amputee groups.SettingUniversity locomotion laboratory.ParticipantsFive lowe... περισσότερα »
Smaller amplitude of H-reflex in females with patellofemoral pain: Thinking outside proximal, local and distal factors
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Publication date: Available online 4 January 2016 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Danilo de Oliveira Silva, Fernando Henrique Magalhães, Nathálie Clara Souto Faria, Marcella Ferraz Pazzinatto, Deisi Ferrari, Evangelos Pappas, Fábio Mícolis de Azevedo Objective(s)To investigate whether vastus medialis (VM) H-reflexes differ based on the presence or absence of patellofemoral pain (PFP). An additional objective was to assess the capability of VM H-reflex measurements in discriminating accurately between females with and without PFP.DesignCross-secti...περισσότερα »
Bony bumps in the mouth
Bony bumps in the mouth via CCJM A 79-YEAR-OLD WOMAN with a long history of limited scleroderma was being evaluated in the rheumatology clinic. During routine examination of the oral cavity, masses were noted on her hard palate and... Original enclosures:Chatterjee_BonyBumpsInMouth.pdf
Optimization and simplification of the allergic and hypersensitivity conditions classification for the ICD-11
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Abstract Background Since 2013, an international collaboration of Allergy Academies, including first the World Allergy Organization (WAO), the American Academy of Allergy Asthma and Immunology (AAAAI) and the European Academy of Allergy and Clinical Immunology (EAACI), and than, the American College of Allergy, Asthma and Immunology (ACAAI), the Latin American Society of Allergy, Asthma and […]
Two galactose-α-1,3-galactose carrying peptidases from pork kidney mediate anaphylactogenic responses in delayed meat allergy
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 41 δευτερόλεπτα
Abstract Background Serum IgE-antibodies directed at galactose-α-1,3-galactose (α-Gal) are associated with a novel form of delayed anaphylaxis occuring upon consumption of red meat or innards. Pork kidney is known as the most potent trigger of this syndrome, but the culprit allergens have not yet been identified. The aim of this study was the identification and […]
Primary immunodeficiency disorders,such as ataxia-telangiectasia (A-T) : Noninfectious Granulomas
Noninfectious Granulomas: A Sign of an Underlying Immunodeficiency?: Primary immunodeficiency disorders, such as ataxia-telangiectasia (A-T), may rarely be associated with cutaneous granulomas without an identifiable infection. The authors report a case of a 3-year-old boy with A-T who presented with two persistent ulcerated erythematous nodules. Histopathology was consistent with a granulomatous process secondary to A-T, without an infectious origin. Partial improvement was noted with clobetasol propionate 0.05% cream applied twice daily under occlusion. Of note, the presence of m... περισσότερα »
Excision of Large Lipomas Using Tumescent Local Anesthesia
Excision of Large Lipomas Using Tumescent Local Anesthesia: Background: Many large lipomas are removed under general anesthesia, because more local anesthesia than is safe to inject may be required for complete excision of such large tumors. Methods: The authors performed total excision using tumescent local anesthesia in an outpatient clinic for 23 patients with solitary large lipomas. Results: The longest diameter of the lesions on magnetic resonance imaging ranged from 10 to 22 cm. Mean length of the skin incision was 4.8 cm, and 56 mL of the tumescent solution on average was u...περισσότερα »
Massive odontoameloblastoma arising in the maxilla
Massive odontoameloblastoma arising in the maxilla: a case report: IntroductionOdontoameloblastoma is an extremely rare mixed odontogenic tumor with both epithelial and mesenchymal components. The term odontoameloblastoma first appeared in the 1971 World Health Organization classification (Pindborg JJ., et al.) and is defined as “a neoplasm that includes odontogenic ectomesenchyme in addition to odontogenic epithelium that resembles an ameloblastoma in both structures and behavior.” Because of the aggressive nature and risk of recurrence of the tumor, complete resection is essential...περισσότερα »
Infiltrating angiolipoma of the chest wall
Infiltrating angiolipoma of the chest wall: a rare clinical entity: Angiolipoma is a rare variant of lipoma. Infiltrating chest wall angiolipoma usually presents as painful subcutaneous lesions. There are only a handful of cases reported in the literature. Malignancy is suspected in the differential diagnosis, and hence a tissue diagnosis is needed to rule out an underlying malignancy. Symptomatic infiltrating angiolipoma warrants surgical excision. We report a case of an infiltrating angiolipoma of the chest wall, which was successfully treated with surgical excision.
A lateral neck mass : Intravascular papillary endothelial hyperplasia (Masson's tumor)
Intramuscular sinusoidal haemangioma with secondary Masson's phenomenon by Konda, P., Bavle, R. M., Makarla, S., Muniswamappa, S. via BMJ Case Reports Last 6 Issues Intramuscular haemangiomas (IMHs) are rare benign vascular neoplasms that account for approximately 0.8% of all haemangiomas. The histology of IMHs can reveal cavernous dilated spaces. We report an interesting case of haemangioma in the deep skeletal muscle of the right labial mucosa in a young man involving the orbicularis oris muscle which showed additional features of sinusoidal arrangement with a secondary Masson's phe... περισσότερα »
GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes from ER Stress-Induced Apoptosis
Abstract Bag5 is a member of the BAG family of molecular chaperone regulators and is unusual in that it consists of five BAG domains, which function as modulators of chaperone activity. Bag family proteins play a key role in cellular as well as in cardiac function and their differential expression is reported in heart failure.… Continue reading GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes from ER Stress-Induced Apoptosis
The CREB Transcription Factor Controls Transcriptional Activity of the Human RIC8B Gene
Abstract Proper regulation of gene expression is essential for normal development, cellular growth and differentiation. Differential expression profiles of mRNA coding for vertebrate Ric-8B during embryo and adult stages have been observed. In addition, Ric-8B is expressed in few cerebral nuclei subareas. These facts point to a dynamic control of RIC8B gene expression. In order… Continue reading The CREB Transcription Factor Controls Transcriptional Activity of the Human RIC8B Gene
Sudden sensorineural hearing loss in children: Etiology, management, and outcome
Publication date: Available online 5 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Jacob Pitaro, Avital Bechor-Fellner, Haim Gavriel, Tal Marom, Ephraim Eviatar Background and objectivesPediatric sudden sensorineural hearing loss (SSNHL) is uncommon, and the current guidelines for its management refer to adults. Our objective was to review cases of SSNHL in children and examine… Continue reading Sudden sensorineural hearing loss in children: Etiology, management, and outcome
A pilot study of long noncoding RNA expression profiling by microarray in follicular lymphoma
Publication date: 15 February 2016 Source:Gene, Volume 577, Issue 2 Author(s): Yi Pan, Haixin Li, Yan Guo, Ye Luo, Hua Li, Yong Xu, Jingyu Deng, Baocun Sun from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1IOewEU via IFTTT
Sleep problems and obstructive sleep apnea in children with down syndrome, an overwiew
Publication date: Available online 4 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Mieke Maris, Stijn Verhulst, Marek Wojciechowski, Paul Van de Heyning, An Boudewyns IntroductionChildren with Down syndrome (DS) have a high prevalence of sleep problems, including behavioural sleep disturbances and obstructive sleep apnea. Sleep problems are associated with a wide range of adverse… Continue reading Sleep problems and obstructive sleep apnea in children with down syndrome, an overwiew
Structural analysis and knock-out of a Burkholderia pseudomallei homolog of the eukaryotic transcription coactivator PC4
Publication date: 15 February 2016 Source:Gene, Volume 577, Issue 2 Author(s): Sebastiaan Werten, Christian Kohler, Niklas Johannes Bayer, Ivo Steinmetz, Winfried Hinrichs Graphical abstract from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PI6o8b via IFTTT
Editorial Board
Publication date: 15 February 2016 Source:Gene, Volume 577, Issue 2 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1IOevki via IFTTT
Avoidance of a Potential Tracheoinnominate Fistula by Innominate Artery Re-implantation in a Four Year Old Girl with Tracheostomy Dependence and Pfeiffer Syndrome
Publication date: Available online 4 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Michael D. Olson, R. Paul Boesch, Audra A. Duncan, Shelagh A. Cofer A 4 year old tracheostomy dependent girl with Pfeiffer syndrome was noted on bronchoscopy to have a pulsatile tracheostomal mass. CT chest angiography was consistent with the innominate artery crossing… Continue reading Avoidance of a Potential Tracheoinnominate Fistula by Innominate Artery Re-implantation in a Four Year Old Girl with Tracheostomy Dependence and Pfeiffer Syndrome
The pri-let-7a-2 rs1143770C>T is associated with prognosis of surgically resected non-small cell lung cancer
Publication date: 15 February 2016 Source:Gene, Volume 577, Issue 2 Author(s): Kyung Min Shin, Deuk Kju Jung, Mi Jeong Hong, Hyo Jung Kang, Won Kee Lee, Seung Soo Yoo, Shin Yup Lee, Seung Ick Cha, Jaehee Lee, Chang Ho Kim, Yangki Seok, Sukki Cho, Ji Woong Son, Eung Bae Lee, Sanghoon Jheon, Young Tae Kim,… Continue reading The pri-let-7a-2 rs1143770C>T is associated with prognosis of surgically resected non-small cell lung cancer
Clinical outcomes in a high nursing ratio ward setting for children with obstructive sleep apnea at high risk after adenotonsillectomy
Publication date: Available online 4 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Sarah Arachchi, David S Armstrong, Noel Roberts, Malcolm Baxter, Sarah McLeod, Margot J. Davey, Gillian M. Nixon BackgroundIn 2012 clinical management of children having adenotonsillectomy (AT) for suspected obstructive sleep apnea (OSA) at our tertiary centre changed based on previous research: children… Continue reading Clinical outcomes in a high nursing ratio ward setting for children with obstructive sleep apnea at high risk after adenotonsillectomy
68Ga-DOTA-NOC PET/CT in staging a vagal paraganglioma associated with a novel SDHB mutation
Clinical usefulness of 68Ga-DOTA-NOC PET/CT in staging a vagal paraganglioma associated with a novel SDHB mutation: Description Paragangliomas are rare tumours arising from the autonomic nervous system. Most are benign, however, a few are malignant. The diagnosis of malignancy is dependent on the evidence of metastases. Approximately, 40% of all paragangliomas/pheochromocytomas harbour a germ-line mutation in one of the susceptibility genes identified so far.1 We present a case of a 29-year-old Caucasian man, referred to us on suspicion of a neck paraganglioma based on CT findings. ... περισσότερα »
Graves ophthalmoparesis and ocular myasthenia
Progressive bilateral ophthalmoparesis--a case of simultaneous autoimmunity: balancing Graves ophthalmoparesis and ocular myasthenia: A 44-year-old woman with no medical history presented with a 1-year history of horizontal diplopia, bilateral exophthalmos and progressive asymmetrical ophthalmoparesis, with no pupillary dysfunction or ptosis. Within 3 months of her initial presentation, she noticed paresis of right eye abduction, followed after 1 month with paresis of left eye abduction. Initial investigations revealed positive antiperoxidase antibodies for Graves’ disease and posi... περισσότερα »
Refractory and recurrent mandibular osteomyelitis accompanied by palmoplantar pustulosis and anterior chest pain : SAPHO syndrome with mandibular manifestation
SAPHO syndrome with mandibular manifestation: Descriptionf A 47-year-old man was referred to our hospital due to symptoms of trismus and exacerbation of palmoplantar pustulosis. He had been presenting, for 20 years, with refractory and recurrent mandibular osteomyelitis accompanied by palmoplantar pustulosis and anterior chest pain—symptomatic treatment and surgery had been given at each presentation. When the mandibular lesion got worse this time, he also had anterior chest pain. He had experienced similar episodes before this event. MRI (STIR: short tau inversion recovery) showed ... περισσότερα »
Phase II Trial of Lenvatinib in Medullary Thyroid Cancer
Phase II Trial of Lenvatinib in Medullary Thyroid Cancer: *Purpose:* Positive results of phase I studies evaluating lenvatinib in solid tumors, including thyroid cancer, prompted a phase II trial in advanced medullary thyroid carcinoma (MTC). *Experimental Design:* Fifty-nine patients with unresectable progressive MTC per Response Evaluation Criteria In Solid Tumors (RECIST) v1.0 within the prior 12 months received lenvatinib (24-mg daily, 28-day cycles) until disease progression, unmanageable toxicity, withdrawal, or death. Prior anti-VEGFR therapy was permitted. The primary endpo... περισσότερα »
Radiation and Local Induction of Type I Interferon
Radiation and Local Induction of Type I Interferon: Local irradiation (IR) is widely used in the treatment of primary and metastatic tumors. However, the impact of IR on the immune response is currently being defined. Local and distant relapse after radiotherapy often occurs. The current rationale for the use of IR is based on direct cytotoxicity to cancer cells; however, recent studies have shown that reduction of tumor burden following ablative (large-dose) IR largely depends on type I IFN signaling and CD8+ T-cell response. Here, we review recent findings indicating that antitum... περισσότερα »
IDH2 Mutations in Hematologic and Solid Tumors
IDH2 Mutations in Hematologic and Solid Tumors: Mutations in mitochondrial *IDH2*, one of the three isoforms of *IDH*, were discovered in patients with gliomas in 2009 and subsequently described in acute myelogenous leukemia (AML), angioimmunoblastic T-cell lymphoma, chondrosarcoma, and intrahepatic chloangiocarcinoma. The effects of mutations in *IDH2* on cellular metabolism, the epigenetic state of mutated cells, and cellular differentiation have been elucidated *in vitro* and *in vivo*. Mutations in *IDH2* lead to an enzymatic gain of function that catalyzes the conversion of al...περισσότερα »
Strontium effects on root dentin tubule occlusion and nanomechanical properties
Publication date: Available online 5 January 2016 *Source:*Dental Materials Author(s): Kuniko Saeki, Grayson W. Marshall, Stuart A. Gansky, Charles R. Parkinson, Sally J. Marshall ObjectivesDentin hypersensitivity often is treated by promotion of dentin tubule occlusion. In this in vitro study we evaluated nanomechanical properties and degree of tubule occlusion conferred to sound and demineralized human root dentin following treatment with a 10% (w/w) strontium acetate solution and its relation to the treatment duration and delivery method.Methods24 human cervical root dentin disks... περισσότερα »
Increased risk of venous thromboembolism (VTE). VEGF promotes the growth of highly thrombogenic tumor vessels
VEGF and VTE Risk in Cancer Patients: *Purpose:* Cancer patients are at an increased risk of venous thromboembolism (VTE). VEGF promotes the growth of highly thrombogenic tumor vessels. Here, we explored the utility of soluble plasma VEGF-A (sVEGF) as a biomarker for the prediction of VTE in patients with cancer. *Experimental Design:* Eight hundred four patients with newly diagnosed cancer or progression after remission were prospectively followed for 2 years until the occurrence of VTE or death [tumor sites: brain (*n* = 87), breast (*n* = 137), lung (*n* = 120), gastrointestinal...περισσότερα »
(18F)-FDG PET-CT in patients with localized oesophageal cancer
Valeur pronostique du volume tumoral métabolique sur la TEP au (18F)-fluorodésoxyglucose préthérapeutique pour le cancer de l’œsophage localisé via Cancer/Radiothérapie Publication date: Available online 4 January 2016 *Source:*Cancer/Radiothérapie Author(s): A. Paumier, A. Marquis, P. Trémolières, M. Lacombe, O. Capitain, A.-L. Septans, G. Peyraga, P. Gustin, A. Vénara, É. Ménager, D. Visvikis, O. Couturier, E. Rio, M. Hatt ObjectifÉvaluer la valeur pronostique de différents facteurs préthérapeutiques définis avec la tomographie par émission de positons au ( 18F)-fluorodésoxyglucose (... περισσότερα »
Profiling the Behavior of Distinct Populations of Head and Neck Cancer Stem Cells
Cancers, Vol. 8, Pages 7: Profiling the Behavior of Distinct Populations of Head and Neck Cancer Stem Cells: Cancer stem cells (CSCs) are a subpopulation of tumor cells endowed with self-renewal properties and the capacity to dynamically adapt to physiological changes that occur in the tumor microenvironment. CSCs play a central role in resistance to therapy and long-term disease recurrence. Better characterization and understanding of the available in vitro tools to study the biology of CSCs will improve our knowledge of the processes underlying tumor response to therapy, and will ... περισσότερα »
Regulatory effect of triiodothyronine on brain myelination and astrogliosis after cuprizone-induced demyelination in mice
Regulatory effect of triiodothyronine on brain myelination and astrogliosis after cuprizone-induced demyelination in mice: AbstractChronic demyelination and plaque formation in multiple sclerosis is accompanied by persisting astrogliosis, negatively influencing central nervous system recovery and remyelination. Triiodothyronin (T3) is thought to enhance remyelination in the adult brain by the induction of oligodendrocyte maturation. We investigated additional astrocyte-mediated mechanisms by which T3 might promote remyelination in chronically demyelinated lesions using the cuprizon...περισσότερα »
Echinocystic acid reduces reserpine-induced pain/depression dyad
Echinocystic acid reduces reserpine-induced pain/depression dyad in mice: AbstractChronic pain has consistently been correlated with depression. Echinocystic acid (EA), a natural triterpone enriched in various herbs and used for medicinal purpose in many Asian countries, exhibits anti-inflammatory and analgesic activities. However, little is known the effects of EA on the depression. In present study, we investigated the anti-depression activities in the mouse model of reserpine-induced pain-depression dyad. Reserpine (1 mg/kg subcutaneously daily for 3 days) caused significant dep... περισσότερα »
Occipital lymph node metastasis from nasopharyngeal carcinoma
Occipital lymph node metastasis from nasopharyngeal carcinoma: a special case report and literature review: AbstractCervical lymph node metastasis is common in patients with nasopharyngeal carcinoma (NPC), but occipital lymph node metastasis in NPC patients has not yet been reported. In this case report, we describe an NPC patient with occipital lymph node metastasis. The clinical presentation, diagnostic procedure, treatment, and outcome of this case were presented, with a review of the related literature.
Genetically Profiled Pediatric Extranodal NK/T-Cell Lymphoma Targeting Oncogenic STAT3 Mutation
Successful Treatment of Genetically Profiled Pediatric Extranodal NK/T-Cell Lymphoma Targeting Oncogenic STAT3 Mutation: [image: cover.gif?v=1&s=aca24c650f05e7b82a6847eb] Extranodal natural killer (NK)/T-cell lymphoma (ENKTCL) is a distinct type of non-Hodgkin lymphoma predominantly observed in Asian and Latin American adult males. A 12-year-old Hispanic female diagnosed with ENKTCL was enrolled in our genomic profiling research protocol. We identified specific somatic alterations consistent with diagnosis of ENKTCL as well as oncogenic mutations in *MAP2K1* and *STAT3*. To our ... περισσότερα »
Remote Sensing, Vol. 8, Pages 38: Estimating Soil Moisture with Landsat Data and Its Application in Extracting the Spatial Distribution of Winter Flooded Paddies
Dynamic monitoring of the spatial pattern of winter continuously flooded paddies (WFP) at regional scales is a challenging but highly necessary process in analyzing trace greenhouse gas emissions, water resource management, and food security. The present study was carried out to demonstrate the feasibility of extracting the spatial distribution of WFP through time series imagery of volumetric surface soil moisture content (θv) at the field scale (30 m). A trade-off approach based on the synergistic use of tasseled cap transformation wetness and temperature vegetation dryness index...περισσότερα »
Effect of carboidiimide on thermal denaturation temperature of dentin collagen
Publication date: Available online 5 January 2016 *Source:*Dental Materials Author(s): Milena Cadenaro, Luca Fontanive, Chiara Ottavia Navarra, Pietro Gobbi, Annalisa Mazzoni, Roberto Di Lenarda, Franklin R. Tay, David H. Pashley, Lorenzo Breschi Objectives1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) has been shown to cross-link dentin type I collagen. Increased cross-linking usually elevates the glass transition temperature of polymers. The aim of this study was to evaluate the cross-linking reaction promoted by EDC in different aqueous concentrations by measu... περισσότερα »
Survival of resin infiltrated ceramics under influence of fatigue
Publication date: Available online 4 January 2016 *Source:*Dental Materials Author(s): Moustafa N. Aboushelib, Mohamed H. Elsafi Purposeto evaluate influence of cyclic fatigue on two resin infiltrated ceramics and three all-ceramic crowns manufactured using CAD/CAM technology.Materials and methodsCAD/CAM anatomically shaped crowns were manufactured using two resin infiltrated ceramics (Lava Ultimate and Vita Enamic), two reinforced glass ceramic milling blocks (IPSEmpress CAD and IPSe.max CAD) and a veneered zirconia core (IPSZir CAD). IPSe.max CAD and IPSZir CAD were milled into 0.... περισσότερα »
Brief Overview of This Month’s JACI
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News & Notes
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With: AAAAI Foundation Council Chair William W. Busse, MD, FAAAAI from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mytwwA via IFTTT
Editorial Board
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CME Activities Calendar
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Information for Readers
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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The crossroads of autoimmunity and immunodeficiency: Lessons from polygenic traits and monogenic defects
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Autoimmune and immunodeficiency diseases are outcomes of a dysfunctional immune system and represent 2 sides of the same coin. Multiple single-gene defects have been identified, resulting in rare diseases with features of both autoimmunity and immunodeficiency. On the other hand, more common autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, show a polygenic […]
The extended phenotype of LPS-responsive beige-like anchor protein (LRBA) deficiency
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
LPS-responsive beige-like anchor protein (LRBA) deficiency is a primary immunodeficiency caused by biallelic mutations in LRBA that abolish LRBA protein expression. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1mytsNy via IFTTT
Autoimmunity of the lung and oral mucosa in a multisystem inflammatory disease: The spark that lights the fire in rheumatoid arthritis?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
There is a growing body of evidence to suggest that autoimmunity in patients with rheumatoid arthritis (RA) is initiated outside the joint. This is supported by the observation that circulating autoantibodies, including both rheumatoid factor and anti-citrullinated protein antibody, can be detected in many subjects years before the development of initial joint symptoms leading to […]
Neuronal and brain morphological changes in animal models of schizophrenia
Publication date: 15 March 2016 *Source:*Behavioural Brain Research, Volume 301 Author(s): Gonzalo Flores, Julio César Morales-Medina, Alfonso Diaz Schizophrenia, a severe and debilitating disorder with a high social burden, affects 1% of the adult world population. Available therapies are unable to treat all the symptoms, and result in strong side effects. For this reason, numerous animal models have been generated to elucidate the pathophysiology of this disorder. All these models present neuronal remodeling and abnormalities in spine stability. It is well known that the complexit... περισσότερα »
Supermicrosurgical T-shaped lymphaticovenular anastomosis for the treatment of peripheral lymphedema: Bypassing lymph fluid maximizing lymphatic collector continuity
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The Relationship Between Phosphodiesterase-5 Inhibitors and Nonarteritic Anterior Ischemic Optic Neuropathy.
Background: A cause and effect relationship between phosphodiesterase-5 inhibitor (PDE5I) use and nonarteritic anterior ischemic optic neuropathy (NAION) has been hypothesized based on case reports. Evidence Acquisition: Review of literature. Results: Thirty-nine case reports in the peer-reviewed medical literature have documented a possible relationship between PDE5I consumption and NAION. However, pertinent details, such as the dose and frequency of PDE5I use, and elapsed time between ingestion and onset of vision loss, are lacking from many of these reports. Investigations regard...περισσότερα »
Preferential Ganglion Cell Loss in the Nasal Hemiretina in Patients With Pituitary Tumor.
Background: Analysis of retinal nerve fiber layer thickness and macular ganglion cell layer loss provides a noninvasive method to assess optic chiasmal compression. These techniques may provide valuable data for patient evaluation and management when combined with findings on clinical examination and neuroimaging results. Methods: Data from 20 eyes of 10 patients with pituitary tumor treated at Inha University Hospital from 2011 to 2013 were collected. This included results of ophthalmologic examination, fundus photography, spectral domain optical coherence tomography (SD-OCT), auto...περισσότερα »
Giant Cell Arteritis.
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Assessment of the MSF triage system, separating patients into different wards pending Ebola virus laboratory confirmation, Kailahun, Sierra Leone, July to September 2014.
*Assessment of the MSF triage system, separating patients into different wards pending Ebola virus laboratory confirmation, Kailahun, Sierra Leone, July to September 2014.* Euro Surveill. 2015 Dec 17;20(50) Authors: Vogt F, Fitzpatrick G, Patten G, van den Bergh R, Stinson K, Pandolfi L, Squire J, Decroo T, Declerck H, Van Herp M Abstract Prevention of nosocomial Ebola virus (EBOV) infection among patients admitted to an Ebola management centre (EMC) is paramount. Current Médecins Sans Frontières (MSF) guidelines recommend classifying admitted patients at triage into suspect and...περισσότερα »
Reversible albumin-binding GH possesses a potential once-weekly treatment profile in adult growth hormone deficiency.
*Reversible albumin-binding GH possesses a potential once-weekly treatment profile in adult growth hormone deficiency.* J Clin Endocrinol Metab. 2016 Jan 4;:jc20151991 Authors: Rasmussen MH, Janukonyté J, Klose M, Marina D, Tanvig M, Nielsen LF, Höybye C, Andersen M, Feldt-Rasmussen U, Christiansen JS Abstract CONTEXT: NNC0195-0092 is a reversible albumin-binding growth hormone (GH) derivative, developed for once-weekly administration. OBJECTIVES: Evaluate safety, local tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of multiple once-weekly doses of NNC0195-0092, co... περισσότερα »
The effects of rate on single-word reading assessment.
[image: http:--pubs.asha.org-images-b_pubmed_ful] Related Articles *The effects of rate on single-word reading assessment.* Am J Speech Lang Pathol. 2015 Feb;24(1):13-23 Authors: Carter MD, Walker MM, O'Brien K Abstract PURPOSE: The purpose of this study was to examine the effects of introducing rapid stimulus presentation durations while limiting response durations on the decoding profiles of college students with reading disorders. METHOD: Eighteen college-aged individuals with typical reading abilities and 12 college-aged adults who exhibited reading difficulties participated. ...περισσότερα »
The judicialization of the medical act.
*The judicialization of the medical act.* Braz J Otorhinolaryngol. 2015 Dec 13; Authors: Campos RA, Camargo RA, Neves LR PMID: 26727609 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/22IKrNu via IFTTT
Association between maxillary sinus pathologies and healthy teeth.
*Association between maxillary sinus pathologies and healthy teeth.* Braz J Otorhinolaryngol. 2015 Dec 10; Authors: Roque-Torres GD, Ramirez-Sotelo LR, Vaz SL, de Almeida de Bóscolo SM, Bóscolo FN Abstract INTRODUCTION: The proximity of the roots to the maxillary sinus can create a variety of risks. OBJECTIVE: To evaluate the relationship between the roots of healthy teeth and the maxillary sinus, as well as the occurrence of sinus pathologies. METHODS: Three radiologists analyzed 109 cone beam computed tomography (CBCT) images. The Kappa test was used to assess the intra- and int... περισσότερα »
Analysis of electrically evoked compound action potential of the auditory nerve in children with bilateral cochlear implants.
*Analysis of electrically evoked compound action potential of the auditory nerve in children with bilateral cochlear implants.* Braz J Otorhinolaryngol. 2015 Dec 10; Authors: Caldas FF, Cardoso CC, Barreto MA, Teixeira MS, Hilgenberg AM, Serra LS, Bahmad Junior F Abstract INTRODUCTION: The cochlear implant device has the capacity to measure the electrically evoked compound action potential of the auditory nerve. The neural response telemetry is used in order to measure the electrically evoked compound action potential of the auditory nerve. OBJECTIVE: To analyze the electrically ... περισσότερα »
Auditory evoked potentials in a newborn Wistar rat model of hyperbilirubinemia.
*Auditory evoked potentials in a newborn Wistar rat model of hyperbilirubinemia.* Braz J Otorhinolaryngol. 2015 Dec 2; Authors: Gökdoğan Ç, Genç A, Gülbahar Ö, Gökdoğan O, Helvacı A, Bezgin SÜ, Memiş L Abstract INTRODUCTION: Hyperbilirubinemia is a common health problem in newborns. Its effects can be different according to the level and duration of the hyperbilirubinemia. The toxic effect of bilirubin on the auditory system can be seen as a sensory neural hearing loss or auditory neuropathy spectrum disorder (ANSD). OBJECTIVE: The purpose of our study was to determine the effec...περισσότερα »
The effects of concurrent cognitive tasks on postural sway in healthy subjects.
*The effects of concurrent cognitive tasks on postural sway in healthy subjects.* Braz J Otorhinolaryngol. 2015 Nov 21; Authors: Mujdeci B, Turkyilmaz D, Yagcioglu S, Aksoy S Abstract INTRODUCTION: Keeping balance of the upright stance is a highly practiced daily task for healthy adults and is effectively performed without overt attentional control in most. OBJECTIVE: The purpose of this study was to examine the influence of concurrent cognitive tasks on postural sway in healthy participants. METHODS: This was a prospective study. 20 healthy volunteer subjects were included. The ...περισσότερα »
Objective assessment of surgical technique in rotation and nasal projection variation.
*Objective assessment of surgical technique in rotation and nasal projection variation.* Braz J Otorhinolaryngol. 2015 Dec 10; Authors: Fagundes MS, Moreira AT, Tambara EM, Tenório SB, de Fraga R, Hamerschmidt R Abstract INTRODUCTION: In rhinoplasty, facial esthetic analysis is critical for proper surgical planning. Parameters such as rotation and nasal projection should be routinely evaluated. Few studies have objectively assessed changes in facial angles postoperatively. OBJECTIVE: To evaluate the effectiveness of medial intercrural sutures and of rotation of the nasal tip on ... περισσότερα »
A Rare Case of Toxic Myocarditis Caused by Bacterial Liver Abscess Mimicking Acute Myocardial Infarction.
*A Rare Case of Toxic Myocarditis Caused by Bacterial Liver Abscess Mimicking Acute Myocardial Infarction.* Am J Case Rep. 2016;17:1-5 Authors: Zou Y, Lin L, Xiao H, Xiang D Abstract BACKGROUND Chills, high fever, right upper abdomen pain, and increased white blood cell count are the main and common clinical features of bacterial liver abscess. It is rare to see bacterial liver abscess present symptoms of myocardial injury first, and this can lead to misdiagnosis. CASE REPORT We report a case of toxic myocarditis caused by bacterial liver abscess. The patient first presented wit... περισσότερα »
Temporal bone MRI with 3D-FIESTA in the evaluation of facial and audiovestibular dysfunction.
*Temporal bone MRI with 3D-FIESTA in the evaluation of facial and audiovestibular dysfunction.* Diagn Interv Imaging. 2015 Dec 22; Authors: Cavusoglu M, Cılız DS, Duran S, Ozsoy A, Elverici E, Karaoglanoglu R, Sakman B Abstract PURPOSE: To evaluate the clinical usefulness of magnetic resonance imaging (MRI) of the temporal bone using three-dimensional fast imaging employing steady-state acquisition (3D-FIESTA) sequences in patients with facial and audiovestibular dysfunction. METHODS: We retrospectively reviewed the MR images of 1263 patients who presented with hearing loss (n=4...περισσότερα »
A symptomatic presentation of a rare type of proatlantal artery.
*A symptomatic presentation of a rare type of proatlantal artery.* Diagn Interv Imaging. 2015 Dec 24; Authors: Dimitriade A, Stănciulescu R, Dorobăţ B, Iana G PMID: 26724857 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/22ILpcC via IFTTT
Validation of SCT Methylation As a Hallmark Biomarker for Lung Cancers.
*Validation of SCT Methylation As a Hallmark Biomarker for Lung Cancers.* J Thorac Oncol. 2015 Dec 24; Authors: Zhang YA, Ma X, Sathe A, Fujimoto J, Wistuba II, Lam S, Yatabe Y, Wang YW, Stastny V, Gao B, Larsen JE, Girard L, Liu X, Song K, Behrens C, Kalhor N, Xie Y, Zhang MQ, Minna JD, Gazdar AF Abstract INTRODUCTION: The human secretin gene (SCT) encodes secretin, a hormone with limited tissue distribution. Analysis of the 450k methylation array data in The Cancer Genome Atlas (TCGA) indicated that the SCT promoter region is differentially hypermethylated in lung cancer. Our p... περισσότερα »
Case of pharyngeal cancer not detected during preoperative transoral endoscopy with narrow band imaging.
[image: http:--production.springer.de-OnlineReso] Related Articles *Case of pharyngeal cancer not detected during preoperative transoral endoscopy with narrow band imaging.* Clin J Gastroenterol. 2015 Apr;8(2):68-72 Authors: Tsuji K, Doyama H, Nakanishi H, Takemura K, Moriyama H, Sakumoto M, Tsuyama S, Kurumaya H Abstract We herein report a case of pharyngeal cancer that was not detected during preoperative transoral endoscopy with narrow band imaging (NBI). A 61-year-old female was referred to our hospital for further evaluation of a pharyngeal lesion. Endoscopy revealed a small...περισσότερα »
Current readings: Window-of-opportunity trials for thoracic malignancies.
[image: http:--linkinghub.elsevier.com-ihub-imag] [image: http:--http://ift.tt/1UuR80f] Related Articles *Current readings: Window-of-opportunity trials for thoracic malignancies.* Semin Thorac Cardiovasc Surg. 2014;26(4):323-30 Authors: Tsao AS Abstract Recent major advances in metastatic non-small cell lung cancer have occurred with the identification of molecular biomarker targets and administration of novel agents with resulting improvement in clinical outcomes. In the early-stage setting, personalized therapy with novel agents and molecular profiling are being incorporated i... περισσότερα »
An overview of molecular hybrids in drug discovery.
*An overview of molecular hybrids in drug discovery.* Expert Opin Drug Discov. 2016 Jan 4; Authors: Bérubé G Abstract INTRODUCTION: The hybridization of biologically active molecules is a powerful tool for drug discovery used to target a variety of diseases. It offers the prospect of better drugs for the treatment of a number of illnesses including cancer, malaria, tuberculosis and AIDS. Hybrid drugs can provide combination therapies in a single multi-functional agent and, by doing so, be more specific and powerful than conventional classic treatments. This research field is in ... περισσότερα »
Binaural fusion and listening effort in children who use bilateral cochlear implants: a psychoacoustic and pupillometric study.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Binaural fusion and listening effort in children who use bilateral cochlear implants: a psychoacoustic and pupillometric study.* PLoS One. 2015;10(2):e0117611 Authors: Steel MM, Papsin BC, Gordon KA Abstract Bilateral cochlear implants aim to provide hearing to both ears for children who are deaf and promote binaural/spatial hearing. Benefits are limited by mismatched devices and unilaterally-driven development which could compromise the normal integration of left and right ear input. We... περισσότερα »
Confirmation of an anatomic variation of the recurrent laryngeal nerve at site of entry into the larynx in Chinese population.
*Confirmation of an anatomic variation of the recurrent laryngeal nerve at site of entry into the larynx in Chinese population.* Am J Otolaryngol. 2015 Nov 10; Authors: Shao T, Qiu W, Yang W Abstract OBJECTIVE: This study was aimed at analyzing the frequency of the newly reported variation and the frequency of postoperative palsy associated with three different kinds of known variations. METHODS: We conducted a retrospective study on the data of 2068 consecutive Chinese patients who underwent thyroidectomy. The study included 1362 left and 1507 right (2869 in total) RLNs. RESULTS... περισσότερα »
Administration of Radioactive Iodine Therapy Within 1 Year After Total Thyroidectomy Does Not Affect Vocal Function.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Administration of Radioactive Iodine Therapy Within 1 Year After Total Thyroidectomy Does Not Affect Vocal Function.* J Nucl Med. 2015 Oct;56(10):1480-6 Authors: Ryu CH, Ryu J, Ryu YM, Lee YJ, Lee EK, Kim SK, Kim TS, Kim TH, Lee CY, Park SY, Chung KW, Jung YS Abstract UNLABELLED: The purpose of this study was to evaluate the impact of radioactive iodine therapy (RIT) on vocal function during the early follow-up period after total thyroidectomy (TT) using perceptive and objective measurements, questionnaires regar... περισσότερα »
Neural representation of swallowing is retained with age. A functional neuroimaging study validated by classical and Bayesian inference.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Neural representation of swallowing is retained with age. A functional neuroimaging study validated by classical and Bayesian inference.* Behav Brain Res. 2015 Jun 1;286:308-17 Authors: Windel AS, Mihai PG, Lotze M Abstract We investigated the neural representation of swallowing in two age groups for a total of 51 healthy participants (seniors: average age 64 years; young adults: average age 24 years) using high spatial resolution functional magnetic resonance imaging (fMRI). Two statistical comparisons (classica... περισσότερα »
Laryngeal muscle activity during nasal high-frequency oscillatory ventilation in nonsedated newborn lambs.
[image: http:--misc.karger.com-LinkOutIcons-sk_n] Related Articles *Laryngeal muscle activity during nasal high-frequency oscillatory ventilation in nonsedated newborn lambs.* Neonatology. 2015;107(3):199-205 Authors: Hadj-Ahmed MA, Samson N, Nadeau C, Boudaa N, Praud JP Abstract BACKGROUND: We have previously shown that nasal pressure support ventilation (nPSV) can lead to an active inspiratory laryngeal narrowing in lambs. This, in turn, can limit lung ventilation and divert air into the digestive system, with potentially deleterious consequences. On the other hand, nasal high-...περισσότερα »
Epithelial cells are active participants in vocal fold wound healing: an in vivo animal model of injury.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Epithelial cells are active participants in vocal fold wound healing: an in vivo animal model of injury.* PLoS One. 2014;9(12):e115389 Authors: Leydon C, Imaizumi M, Bartlett RS, Wang SF, Thibeault SL Abstract Vocal fold epithelial cells likely play an important, yet currently poorly defined, role in healing following injury, irritation and inflammation. In the present study, we sought to identify a possible role for growth factors, epidermal growth factor (EGF) and transforming growth f... περισσότερα »
Surface electrical stimulation perturbation context determines the presence of error reduction in swallowing hyolaryngeal kinematics.
[image: http:--pubs.asha.org-images-b_pubmed_ful] Related Articles *Surface electrical stimulation perturbation context determines the presence of error reduction in swallowing hyolaryngeal kinematics.* Am J Speech Lang Pathol. 2015 Feb;24(1):72-80 Authors: Humbert IA, Christopherson H, Lokhande A Abstract PURPOSE: Error-based learning (EBL) involves gradually reducing movement errors caused by a perturbation. When the perturbation has been unexpectedly removed, exaggerated movements occur in the opposite direction of a perturbation effect, known as aftereffects. Our goal was to d... περισσότερα »
An overview of molecular hybrids in drug discovery.
*An overview of molecular hybrids in drug discovery.* Expert Opin Drug Discov. 2016 Jan 4; Authors: Bérubé G Abstract INTRODUCTION: The hybridization of biologically active molecules is a powerful tool for drug discovery used to target a variety of diseases. It offers the prospect of better drugs for the treatment of a number of illnesses including cancer, malaria, tuberculosis and AIDS. Hybrid drugs can provide combination therapies in a single multi-functional agent and, by doing so, be more specific and powerful than conventional classic treatments. This research field is in ... περισσότερα »
Worldwide Prevalence of Fetal Alcohol Spectrum Disorders: A Systematic Literature Review Including Meta-Analysis.
*Worldwide Prevalence of Fetal Alcohol Spectrum Disorders: A Systematic Literature Review Including Meta-Analysis.* Alcohol Clin Exp Res. 2016 Jan;40(1):18-32 Authors: Roozen S, Peters GY, Kok G, Townend D, Nijhuis J, Curfs L Abstract BACKGROUND: Although fetal alcohol spectrum disorders (FASD) affect communities worldwide, little is known about its prevalence. The objective of this study was to provide an overview of the global FASD prevalence. METHODS: We performed a search in multiple electronic bibliographic databases up to August 2015, supplemented with the ascendancy and de...περισσότερα »
Simple preoperative risk scale accurately predicts perioperative mortality following esophagectomy for malignancy.
*Simple preoperative risk scale accurately predicts perioperative mortality following esophagectomy for malignancy.* Dis Esophagus. 2016 Jan 3; Authors: Fuchs HF, Harnsberger CR, Broderick RC, Chang DC, Sandler BJ, Jacobsen GR, Bouvet M, Horgan S Abstract Surgery remains one of the major treatment options available to patients with esophageal cancer, with high mortality in certain cohorts. The aim of this study was to develop a simple preoperative risk scale based on patient factors, hospital factors, and tumor pathology to predict the risk of perioperative mortality following e... περισσότερα »
Allogeneic stem cell transplantation for multiple myeloma: is there a future?
*Allogeneic stem cell transplantation for multiple myeloma: is there a future?* Bone Marrow Transplant. 2016 Jan 4; Authors: Dhakal B, Vesole DH, Hari PN Abstract Despite remarkable progress in survival with the availability of novel agents, an overwhelming majority of patients with multiple myeloma (MM) relapse and the curability of MM remains limited. Genetically defined high-risk MM represents a subgroup with an aggressive disease course despite novel agents. Allogeneic hematopoietic cell transplantation (allo-SCT) is a potentially curative option in MM that has several adva... περισσότερα »
Overcoming Endocrine Resistance in Hormone-Receptor Positive Advanced Breast Cancer-The Emerging Role of CDK4/6 Inhibitors.
*Overcoming Endocrine Resistance in Hormone-Receptor Positive Advanced Breast Cancer-The Emerging Role of CDK4/6 Inhibitors.* Int J Cancer Clin Res. 2015;2(4) Authors: O'Sullivan CC Abstract Dysregulation of the cyclin D and cyclin-dependent kinase (CDK) pathway in cancer cells may inhibit senescence and promote cellular proliferation. By using various different mechanisms, malignant cells may increase cyclin D-dependent activity. The cyclin D-cyclin-dependent kinases 4 and 6 (CDK4/6)-retinoblastoma (Rb) pathway controls the cell cycle restriction point, and is commonly dysregul...περισσότερα »
Engaging Future Clinical Oncology Researchers: An Initiative to Integrate Teaching of Biostatistics and Research Methodology into Specialty Training.
*Engaging Future Clinical Oncology Researchers: An Initiative to Integrate Teaching of Biostatistics and Research Methodology into Specialty Training.* Clin Oncol (R Coll Radiol). 2015 Dec 22; Authors: Turner S, Sundaresan P, Mann K, Pryor D, Gebski V, Shaw T Abstract AIMS: To evaluate the learner's perspectives on a novel workshop programme designed to improve skills in biostatistics, research methodology and critical appraisal in oncology. MATERIALS AND METHODS: Trainees were surveyed anonymously at the completion of each annual workshop from 2012 to 2015. In total, 103 trainees...περισσότερα »
Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper.
*Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper.* J Extracell Vesicles. 2015;4:30087 Authors: Lener T, Gimona M, Aigner L, Börger V, Buzas E, Camussi G, Chaput N, Chatterjee D, Court FA, Del Portillo HA, O'Driscoll L, Fais S, Falcon-Perez JM, Felderhoff-Mueser U, Fraile L, Gho YS, Görgens A, Gupta RC, Hendrix A, Hermann DM, Hill AF, Hochberg F, Horn PA, de Kleijn D, Kordelas L, Kramer BW, Krämer-Albers EM, Laner-Plamberger S, Laitinen S, Leonardi T, Lorenowicz MJ, Lim SK, Lötvall J, Maguire CA, Marcilla A, Nazarenko I, Ochiya T, Pa... περισσότερα »
Comorbidity in older adults with cancer.
*Comorbidity in older adults with cancer.* J Geriatr Oncol. 2015 Dec 22; Authors: Williams GR, Mackenzie A, Magnuson A, Olin R, Chapman A, Mohile S, Allore H, Somerfield MR, Targia V, Extermann M, Cohen HJ, Hurria A, Holmes H Abstract Comorbidity is an issue of growing importance due to changing demographics and the increasing number of adults over the age of 65 with cancer. The best approach to the clinical management and decision-making in older adults with comorbid conditions remains unclear. In May 2015, the Cancer and Aging Research Group, in collaboration with the National ...περισσότερα »
Role of Magnetic Resonance Imaging in Prostate Cancer Screening: A Pilot Study Within the Göteborg Randomised Screening Trial.
*Role of Magnetic Resonance Imaging in Prostate Cancer Screening: A Pilot Study Within the Göteborg Randomised Screening Trial.* Eur Urol. 2015 Dec 24; Authors: Grenabo Bergdahl A, Wilderäng U, Aus G, Carlsson S, Damber JE, Frånlund M, Geterud K, Khatami A, Socratous A, Stranne J, Hellström M, Hugosson J Abstract BACKGROUND: Magnetic resonance imaging (MRI) and targeted biopsies (TB) have shown potential to more accurately detect significant prostate cancer compared with prostate-specific antigen (PSA) and systematic biopsies (SB). OBJECTIVE: To compare sequential screening (PSA+... περισσότερα »
Cartilage-Specific Near-Infrared Fluorophores for Biomedical Imaging.
[image: http:--media.wiley.com-assets-7315-19-Wi] [image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Cartilage-Specific Near-Infrared Fluorophores for Biomedical Imaging.* Angew Chem Int Ed Engl. 2015 Jul 20;54(30):8648-52 Authors: Hyun H, Owens EA, Wada H, Levitz A, Park G, Park MH, Frangioni JV, Henary M, Choi HS Abstract A novel class of near-infrared fluorescent contrast agents was developed. These agents target cartilage with high specificity and this property is inherent to the chemical structure of the fluorophore. After a single low-dose intravenous injec... περισσότερα »
Long-term Oncologic and financial implications of lung cancer screening.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Long-term Oncologic and financial implications of lung cancer screening.* Thorac Surg Clin. 2015 May;25(2):223-9 Authors: Pedersen JH, Sørensen JB Abstract Benefits and risks of computed tomography lung cancer screening are discussed with specific focus on oncologic and financial issues. Earlier disease stage at diagnosis implies that more patients are treated surgically, but the changes in oncologic treatment will not be dramatic. The crucial issue for implementation of screening will be that it is cost effectiv... περισσότερα »
Lung cancer screening: the European perspective.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Lung cancer screening: the European perspective.* Thorac Surg Clin. 2015 May;25(2):161-74 Authors: Veronesi G Abstract European studies have contributed significantly to the understanding of lung cancer screening. Smoking within screening, quality of life, nodule management, minimally invasive treatments, cancer prevention programs, and risk models have been extensively investigated by European groups. Mortality data from European screening studies have not been encouraging so far, but long-term results of the NE...περισσότερα »
Photoallergic reaction in a patient receiving vandetanib for metastatic follicular thyroid carcinoma: a case report.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Photoallergic reaction in a patient receiving vandetanib for metastatic follicular thyroid carcinoma: a case report.* BMC Dermatol. 2015;15:2 Authors: Goldstein J, Patel AB, Curry JL, Subbiah V, Piha-Paul S Abstract BACKGROUND: Novel targeted agents have been increasingly developed and tested in clinical trials over the past 5-10 years, many with unknown and unanticipated side effects. We describe here a case of a patient with a history of metastatic follicular thyroid carcinoma that we ... περισσότερα »
Apoptin interacts with and regulates the activity of protein kinase C beta in cancer cells.
[image: http:--production.springer.de-OnlineReso] Related Articles *Apoptin interacts with and regulates the activity of protein kinase C beta in cancer cells.* Apoptosis. 2015 Jun;20(6):831-42 Authors: Bullenkamp J, Gäken J, Festy F, Chong EZ, Ng T, Tavassoli M Abstract Apoptin, the VP3 protein from chicken anaemia virus (CAV), induces tumour cell-specific cell death and represents a potential future anti-cancer therapeutic. In tumour but not in normal cells, Apoptin is phosphorylated and translocates to the nucleus, enabling its cytotoxic activity. Recently, the β isozyme of pr...περισσότερα »
Informed consent, biobank research, and locality: perceptions of breast cancer patients in three European countries.
Related Articles *Informed consent, biobank research, and locality: perceptions of breast cancer patients in three European countries.* J Empir Res Hum Res Ethics. 2014 Jul;9(3):48-55 Authors: Petersen I, Desmedt C, Harris A, Buffa F, Kollek R Abstract Comparative studies are missing that explore how socio-cultural and institutional circumstances influence patient comprehension and expectations regarding informed consent for current and future research on their tissue and data. This study compares how breast cancer patients in three European countries (the United Kingdom, Belgium... περισσότερα »
Investigational therapies targeting signal transducer and activator of transcription 3 for the treatment of cancer.
Related Articles *Investigational therapies targeting signal transducer and activator of transcription 3 for the treatment of cancer.* Expert Opin Investig Drugs. 2015 Jun;24(6):809-24 Authors: Santoni M, Massari F, Del Re M, Ciccarese C, Piva F, Principato G, Montironi R, Santini D, Danesi R, Tortora G, Cascinu S Abstract INTRODUCTION: Signal transducer and activator of transcription 3 (STAT3) mediates the expression of a variety of genes in response to cell stimuli and thus plays a key role in several cellular processes such as cell growth and apoptosis. Deregulation of the STA... περισσότερα »
Association between maxillary sinus pathologies and healthy teeth.
*Association between maxillary sinus pathologies and healthy teeth.* Braz J Otorhinolaryngol. 2015 Dec 10; Authors: Roque-Torres GD, Ramirez-Sotelo LR, Vaz SL, de Almeida de Bóscolo SM, Bóscolo FN Abstract INTRODUCTION: The proximity of the roots to the maxillary sinus can create a variety of risks. OBJECTIVE: To evaluate the relationship between the roots of healthy teeth and the maxillary sinus, as well as the occurrence of sinus pathologies. METHODS: Three radiologists analyzed 109 cone beam computed tomography (CBCT) images. The Kappa test was used to assess the intra- and int... περισσότερα »
Analysis of electrically evoked compound action potential of the auditory nerve in children with bilateral cochlear implants.
*Analysis of electrically evoked compound action potential of the auditory nerve in children with bilateral cochlear implants.* Braz J Otorhinolaryngol. 2015 Dec 10; Authors: Caldas FF, Cardoso CC, Barreto MA, Teixeira MS, Hilgenberg AM, Serra LS, Bahmad Junior F Abstract INTRODUCTION: The cochlear implant device has the capacity to measure the electrically evoked compound action potential of the auditory nerve. The neural response telemetry is used in order to measure the electrically evoked compound action potential of the auditory nerve. OBJECTIVE: To analyze the electrically ... περισσότερα »
Auditory evoked potentials in a newborn Wistar rat model of hyperbilirubinemia.
*Auditory evoked potentials in a newborn Wistar rat model of hyperbilirubinemia.* Braz J Otorhinolaryngol. 2015 Dec 2; Authors: Gökdoğan Ç, Genç A, Gülbahar Ö, Gökdoğan O, Helvacı A, Bezgin SÜ, Memiş L Abstract INTRODUCTION: Hyperbilirubinemia is a common health problem in newborns. Its effects can be different according to the level and duration of the hyperbilirubinemia. The toxic effect of bilirubin on the auditory system can be seen as a sensory neural hearing loss or auditory neuropathy spectrum disorder (ANSD). OBJECTIVE: The purpose of our study was to determine the effec...περισσότερα »
Pharmacological Modulation of Lung Carcinogenesis in Smokers: Preclinical and Clinical Evidence.
*Pharmacological Modulation of Lung Carcinogenesis in Smokers: Preclinical and Clinical Evidence.* Trends Pharmacol Sci. 2015 Dec 22; Authors: De Flora S, Ganchev G, Iltcheva M, La Maestra S, Micale RT, Steele VE, Balansky R Abstract Many drugs in common use possess pleiotropic properties that make them capable of interfering with carcinogenesis mechanisms. We discuss here the ability of pharmacological agents to mitigate the pulmonary carcinogenicity of mainstream cigarette smoke. The evaluated agents include anti-inflammatory drugs (budesonide, celecoxib, aspirin, naproxen, l... περισσότερα »
Angiogenesis inhibitor; +27 new citations
27 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *Angiogenesis inhibitor* These pubmed results were generated on 2016/01/05 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 1 via ola Kala on Inoreader http://ift.tt/QGMHBq(((Angiogenesis%20inhibitor)%20AND%20%222016%2F01%2F03%2006.56%22%5BMHDA%5D%3A%222016%2F01%2F0... περισσότερα »
The Role of Neoadjuvant Chemotherapy in the Treatment of Nasopharyngeal Carcinoma: A Multi-Institutional Retrospective Study Using Propensity Score Matching Analysis.
*The Role of Neoadjuvant Chemotherapy in the Treatment of Nasopharyngeal Carcinoma: A Multi-Institutional Retrospective Study Using Propensity Score Matching Analysis.* Cancer Res Treat. 2015 Dec 28; Authors: Song JH, Wu HG, Keam BS, Hah JH, Ahn YC, Oh D, Noh JM, Park HJ, Lee CG, Keum KC, Cha J, Cho KH, Moon SH, Kim JY, Chung WK, Oh YT, Kim WT, Cho MJ, Kay CS, Kim YS Abstract Purpose: We compared the treatment results and toxicity in nasopharyngeal carcinoma (NPC) patients treated with concurrent chemotherapy (CCRT) alone (the CRT arm) or neoadjuvant chemotherapy followed by CCR... περισσότερα »
The judicialization of the medical act.
*The judicialization of the medical act.* Braz J Otorhinolaryngol. 2015 Dec 13; Authors: Campos RA, Camargo RA, Neves LR PMID: 26727609 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/22IKrNu via IFTTT
Quantum Dot-Bead-DNA Probe-Based Hybridization Fluorescence Assays on Microfluidic Chips.
*Quantum Dot-Bead-DNA Probe-Based Hybridization Fluorescence Assays on Microfluidic Chips.* J Nanosci Nanotechnol. 2015 Oct;15(10):7918-21 Authors: Ankireddy SR, Kim J Abstract The development of chip-based, quantum dot (QD)-bead-DNA conjugate probes for hybridization detection is a prime research focus in the field of microfluidics. QD-Bead-DNA probe-based hybridization detection methods are often called "bead-based assays," and their success is substantially influenced by the dispensing and manipulation capabilities of microfluidic technology. Met was identified as a prognosti...περισσότερα »
Optimization of Look-Locker Turbo-Field Echo-Planar Imaging and Evaluation of Its Accuracy in Head and Neck 3D T1 Mapping.
*Optimization of Look-Locker Turbo-Field Echo-Planar Imaging and Evaluation of Its Accuracy in Head and Neck 3D T<sub>1</sub> Mapping.* Magn Reson Med Sci. 2015 Dec 28; Authors: Maehara M, Monma M, Nitanai T, Matsumoto T, Fukuma Y Abstract PURPOSE: We present a sequence for T1 relaxation-time mapping that enables a rapid and accurate measuring. The sequence is based on the Look-Locker method by employing turbo-field echo-planar imaging (TFEPI) acquisitions and time to free relaxation after constant application of the radiofrequency (RF) pulses. We optimized the sequenc... περισσότερα »
Emotional Intent Modulates The Neural Substrates Of Creativity: An fMRI Study of Emotionally Targeted Improvisation in Jazz Musicians.
*Emotional Intent Modulates The Neural Substrates Of Creativity: An fMRI Study of Emotionally Targeted Improvisation in Jazz Musicians.* Sci Rep. 2016;6:18460 Authors: McPherson MJ, Barrett FS, Lopez-Gonzalez M, Jiradejvong P, Limb CJ Abstract Emotion is a primary motivator for creative behaviors, yet the interaction between the neural systems involved in creativity and those involved in emotion has not been studied. In the current study, we addressed this gap by using fMRI to examine piano improvisation in response to emotional cues. We showed twelve professional jazz pianists p... περισσότερα »
Association between treatment-related lymphopenia and overall survival in elderly patients with newly diagnosed glioblastoma.
*Association between treatment-related lymphopenia and overall survival in elderly patients with newly diagnosed glioblastoma.* J Neurooncol. 2016 Jan 4; Authors: Mendez JS, Govindan A, Leong J, Gao F, Huang J, Campian JL Abstract Management of patients with glioblastoma (GBM) often includes radiation (RT) and temozolomide (TMZ). The association between severe treatment-related lymphopenia (TRL) after the standard chemoradiation and reduced survival has been reported in GBM patients with the median age of 57. Similar findings were described in patients with head and neck, non-sm... περισσότερα »
Healing of the tympanic membrane after surgical intervention for atelectasis of the middle ear in sixty-two adults.
*Healing of the tympanic membrane after surgical intervention for atelectasis of the middle ear in sixty-two adults.* Clin Otolaryngol. 2016 Jan 4; Authors: Noij KS, Noij DP, Borgstein J Abstract In treating atelectasis of the middle ear multiple techniques have been described, including grafting of the eardrum defect e.g. with perichondrium or cartilage.(1) Several studies suggested that excision of the retraction pocket in pediatric ears does not require grafting. The spontaneous healing capacity of the pediatric tympanic membrane (TM) ranged from 87.2% to 96.8%.(2-5) These re... περισσότερα »
Functional outcome and quality of life after a maxillectomy: a comparison between an implant supported obturator and implant supported fixed prostheses in a free vascularized flap.
*Functional outcome and quality of life after a maxillectomy: a comparison between an implant supported obturator and implant supported fixed prostheses in a free vascularized flap.* Clin Oral Implants Res. 2016 Jan 4; Authors: Wang F, Huang W, Zhang C, Sun J, Qu X, Wu Y Abstract OBJECTIVE: Defects of the maxilla caused by tumor resection create high levels of psychological and physical trauma for patients. The application of osseointegrated dental implants using either an obturator prosthesis or a free vascularized flap has tremendously changed the retention and stability of th... περισσότερα »
Extranodal natural killer/T-cell lymphoma, nasal type developing central nervous system and epididymis involvement immediately after concurrent chemoradiotherapy.
*Extranodal natural killer/T-cell lymphoma, nasal type developing central nervous system and epididymis involvement immediately after concurrent chemoradiotherapy.* Rinsho Ketsueki. 2015;56(12):2472-6 Authors: Sasaki Y, Yonezawa A, Kinoshita Y, Kitagawa T, Mori M, Onaka T, Imada K Abstract A 66-year-old man showed central nervous system (CNS) and epididymis involvement after concurrent chemoradiotherapy for extranodal natural killer/T-cell lymphoma, nasal type (ENKL). The patient experienced continuous nasal obstruction. CT revealed a mass in the nasal cavity and paranasal sinu...περισσότερα »
Clinical significance of arterial stiffness in idiopathic sudden sensorineural hearing loss.
*Clinical significance of arterial stiffness in idiopathic sudden sensorineural hearing loss.* Laryngoscope. 2016 Jan 4; Authors: Chung JH, Lee SH, Park CW, Kim C, Park JK, Shin JH Abstract OBJECTIVES/HYPOTHESIS: To investigate the clinical significance of arterial stiffness in the development and prognosis of idiopathic sudden sensorineural hearing loss (SSNHL). STUDY DESIGN: A prospective case-control study. METHODS: Fifty-four adult patients with idiopathic SSNHL and 54 age- and sex-matched controls were evaluated between January 2014 and May 2015. Arterial stiffness was asses...περισσότερα »
Validation of SCT Methylation As a Hallmark Biomarker for Lung Cancers.
*Validation of SCT Methylation As a Hallmark Biomarker for Lung Cancers.* J Thorac Oncol. 2015 Dec 24; Authors: Zhang YA, Ma X, Sathe A, Fujimoto J, Wistuba II, Lam S, Yatabe Y, Wang YW, Stastny V, Gao B, Larsen JE, Girard L, Liu X, Song K, Behrens C, Kalhor N, Xie Y, Zhang MQ, Minna JD, Gazdar AF Abstract INTRODUCTION: The human secretin gene (SCT) encodes secretin, a hormone with limited tissue distribution. Analysis of the 450k methylation array data in The Cancer Genome Atlas (TCGA) indicated that the SCT promoter region is differentially hypermethylated in lung cancer. Our p... περισσότερα »
Proximity of the Mandibular Canal to Teeth and Cortical Bone.
*Proximity of the Mandibular Canal to Teeth and Cortical Bone.* J Endod. 2015 Dec 24; Authors: Kawashima Y, Sakai O, Shosho D, Kaneda T, Gohel A Abstract INTRODUCTION: The proximity of the inferior alveolar canal to the mandibular molar roots may pose a risk of injury during various dental surgeries. The purpose of this study was to evaluate age-related and gender-related changes by using cone-beam computed tomography images between the roots of the second molars, mandibular cortex, and the inferior alveolar canal. METHODS: One hundred fifty-five patients (68 men, 87 women), 20 y...περισσότερα »
Structure-Function Analysis of the Mcl-1 Protein Identifies a Novel Senescence-regulating Domain.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Structure-Function Analysis of the Mcl-1 Protein Identifies a Novel Senescence-regulating Domain.* J Biol Chem. 2015 Sep 4;290(36):21962-75 Authors: Demelash A, Pfannenstiel LW, Tannenbaum CS, Li X, Kalady MF, DeVecchio J, Gastman BR Abstract Unlike other antiapoptotic Bcl-2 family members, Mcl-1 also mediates resistance to cancer therapy by uniquely inhibiting chemotherapy-induced senescence (CIS). In general, Bcl-2 family members regulate apoptosis at the level of the mitochondria through a common prosurvival b...περισσότερα »
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sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
With: AAAAI Foundation Council Chair William W. Busse, MD, FAAAAI from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mytwwA via IFTTT
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sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
▪ 2016 Allergy/Immunology Self-Assessment from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1kI6vWf via IFTTT
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sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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The crossroads of autoimmunity and immunodeficiency: Lessons from polygenic traits and monogenic defects
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Autoimmune and immunodeficiency diseases are outcomes of a dysfunctional immune system and represent 2 sides of the same coin. Multiple single-gene defects have been identified, resulting in rare diseases with features of both autoimmunity and immunodeficiency. On the other hand, more common autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, show a polygenic […]
The extended phenotype of LPS-responsive beige-like anchor protein (LRBA) deficiency
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
LPS-responsive beige-like anchor protein (LRBA) deficiency is a primary immunodeficiency caused by biallelic mutations in LRBA that abolish LRBA protein expression. from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mytsNy via IFTTT
Autoimmunity of the lung and oral mucosa in a multisystem inflammatory disease: The spark that lights the fire in rheumatoid arthritis?
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
There is a growing body of evidence to suggest that autoimmunity in patients with rheumatoid arthritis (RA) is initiated outside the joint. This is supported by the observation that circulating autoantibodies, including both rheumatoid factor and anti-citrullinated protein antibody, can be detected in many subjects years before the development of initial joint symptoms leading to […]
The Editors’ Choice
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Although extensive alopecia areata (AA) has a major effect on patients’ quality of life, its treatments are limited. Oral immunosuppressants have shown efficacy, but their side effects preclude long-term use. IL-12/IL-23p40 levels were recently found to be highly increased in AA lesions. Guttman-Yassky et al (p 301) evaluated hair regrowth in 3 patients with extensive […]
Alterations in immune function with biologic therapies for autoimmune disease
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Autoimmune disorders, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, and others, are characterized by dysregulation of various aspects of normal immunity and inflammation. Biologic agents targeting key components of the dysregulated immune response have dramatically improved patient outcomes and transformed treatment paradigms for a number of systemic inflammatory autoimmune diseases. Despite their excellent efficacy, because […]
Correction
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
With regard to the article in the 2013 issue entitled “The novel structure of the cockroach allergen Bla g 1 has implications for allergenicity and exposure assessment” (J Allergy Clin Immunol 2013;132:1420-6), the authors report that the article incorrectly stated the previously determined standard units of Bla g 2. It should state that 1 standard […]
The suprascapular notch narrows with aging: a preliminary solution of the old conjecture based on a 3D-CT evaluation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Purpose The purpose of this study was to describe the morphology of the suprascapular notch in terms of age distribution. We hypothesized that the notch narrows with aging. Methods Seven hundred and sixty consecutive patients (465 men and 295 women) scheduled for a shoulder surgery were retrospectively reviewed. A 3D-CT of the shoulder was […]
Identifying migrants in Roman London using lead and strontium stable isotopes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: February 2016 Source:Journal of Archaeological Science, Volume 66 Author(s): Heidi Shaw, Janet Montgomery, Rebecca Redfern, Rebecca Gowland, Jane Evans The ancient settlement of Londinium (London) has long been characterized as a major commercial and bureaucratic centre of the Roman province of Britain (Britannia). Primary source information indicates that people were drawn to the […]
Deficiencies in the Management of Iron Deficiency Anemia During Childhood
Limited high-quality evidence supports the management of iron deficiency anemia (IDA). To assess our institutional performance in this area, we retrospectively reviewed IDA treatment practices in 195 consecutive children referred to our center from 2006 to mid-2010. The majority of children were ≤4 years old (64%) and had nutritional IDA (74%). In 11- to 18-year-old patients (31%), the primary etiology was menorrhagia (42%). Many were referred directly to the emergency department and/or prescribed iron doses outside the recommended range. Poor medication adherence and being lost-t...περισσότερα »
Sinus of Valsalva Sclerosis is Associated with Conduction Abnormalities on 12-Lead Standard ECG
The post Sinus of Valsalva Sclerosis is Associated with Conduction Abnormalities on 12-Lead Standard ECG appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PHUJpV via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PHYFaj via IFTTT
Morphology and morphometry of lateral atlantoaxial joint meniscoids
Abstract The lateral atlantoaxial joints contain folds of synovium termed meniscoids that may potentially contribute to cervical spine pain; however, the anatomy of these structures has not been comprehensively investigated. The purpose of this study was to explore the morphology and morphometry of lateral atlantoaxial joint meniscoids. Twelve cadaveric hemi-spines (6 female; 6 left; mean 81.5 years, SD 7.3) were obtained for dissection and disarticulation of the lateral atlantoaxial joints. Meniscoids were identified and measurements made of surface area, length, and surrounding ... περισσότερα »
The superior mesenteric artery and the variations of the colic patterns. A new anatomical and radiological classification of the colic arteries
Abstract The superior mesenteric artery (SMA) supplies irrigation to the small intestine, ascending and a variable area of the transverse colon. Although medical imaging and surgical procedures have been widely developed in the last decades, the anatomy of the SMA using advanced imaging technology remains to be elucidated. Previous studies have used small sample sizes of cadaveric or radiological samples to propose a number of classifications for the SMA. In this study, we aimed to provide a more detailed description and useful classification of the SMA and its main branches [middl...περισσότερα »
Gross anatomical classification of the courses of the human sublingual artery
Abstract The purpose of the present study was to classify the courses of the human sublingual artery. For this purpose, the arteries supplying the floor of the mouth and the tongue were gross anatomically investigated using 101 sides of 53 cadavers. The courses were divided into three categories: those passing medial or lateral to the hyoglossus (categories M and L) and that piercing the mylohyoid (category P); they were subdivided into five types. Category M had one type, regarded as the usual one, in which the lingual artery took the usual pattern of distribution. Categories L an... περισσότερα »
Light and electron microscopic study of the eyelids, conjunctiva-associated lymphoid tissue and lacrimal gland in Bilgorajska Goose (Anser anser )
Abstract Normal structure of the accessory organs of the eye is essential for normal eye physiology. Among the most important accessory organs of the eye are the eyelids, the conjunctiva-associated lymphoid tissue (CALT) and the lacrimal gland (LG). The aim of this study was to demonstrate the histological structure of the eyelids and LG by histochemical and ultrastructural analysis. The study was performed on 13 adult female Bilgorajska geese. Eyelid samples were stained with the Alcian blue (AB pH 2.5) and periodic acid-Schiff (PAS) methods. Staining methods used for LG were AB ... περισσότερα »
A case of an additional right external iliac vein surrounding the right external iliac artery and lacking the right common iliac vein
Abstract A case of an additional right external iliac vein lacking a right common iliac vein was found in an 84-year-old female cadaver during a dissection course at Aichi Medical University in 2014. The findings are reported and discussed from the embryological and clinical viewpoints. The right and left iliac venous systems were macroscopically observed with attention to the homonymous arteries and the inferior vena cava. In this cadaver, a preaortic external iliac vein originated from a right external iliac vein and drained directly into the inferior vena cava. The preaortic and... περισσότερα »
Sling and swathe modification for immobilization of posterior glenohumeral dislocations
Publication date: Available online 5 January 2016 *Source:*The American Journal of Emergency Medicine Author(s): Andrew P. Harris, Steven F. DeFroda, Joseph A. Gil, Gregory R. Waryasz from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Ut3dma via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PHYH1W via IFTTT
Directions in current and future phytolith research
Publication date: Available online 4 January 2016 *Source:*Journal of Archaeological Science Author(s): Débora Zurro, Juan José García-Granero, Carla Lancelotti, Marco Madella The analysis of phytoliths has progressed immensely in recent years. Increases in the number of phytolith works within several disciplines has substantially extended our knowledge about these microfossils, while at the same time diversifying the approaches by which they can be used as archaeological and palaeoenvironmental proxies. The insufficient standardisation of these works, however, greatly increases the... περισσότερα »
Sinus of Valsalva Sclerosis is Associated with Conduction Abnormalities on 12-Lead Standard ECG
The post Sinus of Valsalva Sclerosis is Associated with Conduction Abnormalities on 12-Lead Standard ECG appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PHUJpV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OJewZ3 via IFTTT
Light/Dark Environmental Cycle Imposes a Daily Profile in the Expression of microRNAs in Rat CD133+ Cells
Abstract The phenotype of primary cells in culture varies according to the donor environmental condition. We recently showed that the time of the day imposes a molecular program linked to the inflammatory response that is heritable in culture. Here we investigated whether microRNAs (miRNAs) would show differential expression according to the time when cells were obtained, namely daytime or nighttime. Cells obtained from explants of cremaster muscle and cultivated until confluence (∼20 days) presented high CD133 expression. Global miRNA expression analysis was performed through dee...περισσότερα »
Why do Patients who Underwent Laparoscopic Adjustable Gastric Banding Surgery, Decide to Remove their Band, a Retrospective Cohort Study
The post Why do Patients who Underwent Laparoscopic Adjustable Gastric Banding Surgery, Decide to Remove their Band, a Retrospective Cohort Study appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PHUHOO via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PHUM54 via IFTTT
Evidence Based Theory for Integrated Genome Regulation of Ontogeny – an Unprecedented Role of Nuclear FGFR1 Signaling
Abstract Genetic experiments have positioned the *fgfr1* gene at the top of the gene hierarchy that governs gastrulation, as well as the subsequent development of the major body axes, nervous system, muscles, and bones, by affecting downstream genes that control the cell cycle, pluripotency and differentiation, as well as microRNAs. Studies show that this regulation is executed by a single protein, the nuclear isoform of FGFR1 (nFGFR1), which integrates signals from development-initiating factors such as Retinoic Acid (RA), and operates at the interface of genomic and epigenomic i...περισσότερα »
Presumed Primary Frozen Shoulder – Clinical Characteristics and Findings of Magnetic Resonance Imaging
The post Presumed Primary Frozen Shoulder – Clinical Characteristics and Findings of Magnetic Resonance Imaging appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1O2H7VT via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OJev7A via IFTTT
Cell-Autonomous Brown-Like Adipogenesis of Preadipocytes from Retinoblastoma Haploinsufficient Mice
Abstract Mechanisms behind the emergence of brown adipocyte-like (brite or beige) adipocytes within white adipose tissue (WAT) are of interest. Retinoblastoma protein gene (Rb) haploinsufficiency associates in mice with improved metabolic regulation linked to a greater capacity for fatty acid oxidation and thermogenesis in WAT. We aimed to explain a feasible mechanism of WAT-to-BAT remodeling in this model. Differentiated primary adipocytes and Sca1-positive preadipocytes derived from adipose depots of Rb+/− mice and wild-type siblings were compared. Primary white Rb+/− adipocytes...περισσότερα »
Meta Analysis of Etiology and its Clinical and Radiological Correlation in Cases of Craniomaxillofacial Trauma
Abstract Aim The present study was planned to investigate the etiology of injuries and to analyze correlation between clinical and radiological findings in cases of craniomaxillofacial trauma. Study Design An 18 months cross-sectional study was done and 325 patients with maxillofacial fractures were analyzed from January 2013 to June 2014 who reported to the department of oral and maxillofacial surgery, Aligarh, Uttar Pradesh. Data was recorded in a preformed case sheet which included: patient's demographic data, cause of injury, type of injury, treatment plan. Results Out of th... περισσότερα »
A therapeutic cancer vaccine against GL261 murine glioma
Background: Glioblastoma (GBM) is the deadliest of brain tumors. Standard treatment for GBM is surgery, followed by combined radiation therapy and chemotherapy. Current therapy prolongs survival but does not offer a cure. We report on a novel immunotherapy against GBM, tested in an animal model of C57BL/6 mice injected intra-cranially with a lethal dose of murine GL261 glioma cells. Methods: Ten week-old C57BL/6 mice were anesthetized before injection of 2 × 10 4 GL261 cells in the right cerebral hemisphere and after 3 days half of the mice were administered a single subcutaneous ...περισσότερα »
Antarctic clouds studied for first time in five decades
[image: NationalGeographic_1364555.jpg] AWARE project will help unravel effects of global warming. Nature 529 12 doi: 10.1038/529012a [image: 1UsV69a] from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/22IJKUz via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PHUKu3 via IFTTT
Evidence Based Theory for Integrated Genome Regulation of Ontogeny – an Unprecedented Role of Nuclear FGFR1 Signaling
Abstract Genetic experiments have positioned the fgfr1 gene at the top of the gene hierarchy that governs gastrulation, as well as the subsequent development of the major body axes, nervous system, muscles, and bones, by affecting downstream genes that control the cell cycle, pluripotency and differentiation, as well as microRNAs. Studies show that this regulation… Continue reading Evidence Based Theory for Integrated Genome Regulation of Ontogeny – an Unprecedented Role of Nuclear FGFR1 Signaling
Presumed Primary Frozen Shoulder – Clinical Characteristics and Findings of Magnetic Resonance Imaging
The post Presumed Primary Frozen Shoulder – Clinical Characteristics and Findings of Magnetic Resonance Imaging appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1O2H7VT via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OJev7A via IFTTT… Continue reading Presumed Primary Frozen Shoulder – Clinical Characteristics and Findings of Magnetic Res... περισσότερα »
Kinetics and mass spectrometric measurements of myoglobin unfolding in aqueous ionic liquid solutions
Publication date: April 2016 Source:International Journal of Biological Macromolecules, Volume 85 Author(s): Miranda C. Miller, Sylvia L. Hanna, Kelsey G. DeFrates, Olivia C. Fiebig, Timothy D. Vaden Recent studies have characterized the effects of aqueous ionic liquids on myoglobin unfolding for the broader purposes of understanding their effects on protein structures, stabilities, and ultimately biocompatibilities… Continue reading Kinetics and mass spectrometric measurements of myoglobin unfolding in aqueous ionic liquid solutions
Aging effects on discrimination learning, logical reasoning and memory in pet dogs
Abstract In laboratory dogs, aging leads to a decline in various cognitive domains such as learning, memory and behavioural flexibility. However, much less is known about aging in pet dogs, i.e. dogs that are exposed to different home environments by their caregivers. We used tasks on a touchscreen apparatus to detect differences in various cognitive… Continue reading Aging effects on discrimination learning, logical reasoning and memory in pet dogs
Differential changes and interactions of autonomic functioning and sleep architecture before and after 50 years of age
Abstract We hypothesize that the time when age-related changes in autonomic functioning and in sleep structure occur are different and that autonomic functioning modulates sleep architecture differently before and after 50 years of age. Sixty-eight healthy subjects (aged 20 to 79 years old, 49 of them women) were enrolled. Correlation analysis revealed that wake after… Continue reading Differential changes and interactions of autonomic functioning and sleep architecture before and after 50 years of age
Cell-Autonomous Brown-Like Adipogenesis of Preadipocytes from Retinoblastoma Haploinsufficient Mice
Abstract Mechanisms behind the emergence of brown adipocyte-like (brite or beige) adipocytes within white adipose tissue (WAT) are of interest. Retinoblastoma protein gene (Rb) haploinsufficiency associates in mice with improved metabolic regulation linked to a greater capacity for fatty acid oxidation and thermogenesis in WAT. We aimed to explain a feasible mechanism of WAT-to-BAT remodeling… Continue reading Cell-Autonomous Brown-Like Adipogenesis of Preadipocytes from Retinoblastoma Haploinsufficient Mice
Meta Analysis of Etiology and its Clinical and Radiological Correlation in Cases of Craniomaxillofacial Trauma
Abstract Aim The present study was planned to investigate the etiology of injuries and to analyze correlation between clinical and radiological findings in cases of craniomaxillofacial trauma. Study Design An 18 months cross-sectional study was done and 325 patients with maxillofacial fractures were analyzed from January 2013 to June 2014 who reported to the department… Continue reading Meta Analysis of Etiology and its Clinical and Radiological Correlation in Cases of Craniomaxillofacial Trauma
Blind boy learns to ‘see’ with technique used by BATS: Ruben, 8, clicks his … – Daily Mail
Daily Mail Blind boy learns to ‘see’ with technique used by BATS: Ruben, 8, clicks his … Daily Mail Mr Kish has been practising echolocation since he was a child, after being blinded at just 13 months old by an aggressive form of eye cancer – and his talent has earnt him the nickname Batman.… Continue reading Blind boy learns to ‘see’ with technique used by BATS: Ruben, 8, clicks his … – Daily Mail
The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin
The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin Cell Research advance online publication, January 5 2016. doi:10.1038/cr.2016.1 Authors: Susanne V Schmidt, Wolfgang Krebs, Thomas Ulas, Jia Xue, Kevin Baßler, Patrick Günther, Anna-Lena Hardt, Hartmut Schultze, Jil Sander, Kathrin Klee, Heidi Theis, Michael Kraut, Marc Beyer & Joachim L Schultze from… Continue reading The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin
A therapeutic cancer vaccine against GL261 murine glioma
Background: Glioblastoma (GBM) is the deadliest of brain tumors. Standard treatment for GBM is surgery, followed by combined radiation therapy and chemotherapy. Current therapy prolongs survival but does not offer a cure. We report on a novel immunotherapy against GBM, tested in an animal model of C57BL/6 mice injected intra-cranially with a lethal dose of… Continue reading A therapeutic cancer vaccine against GL261 murine glioma
Blind boy learns to ‘see’ with technique used by BATS: Ruben, 8, clicks his … – Daily Mail
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Daily Mail Blind boy learns to ‘see’ with technique used by BATS: Ruben, 8, clicks his … Daily Mail Mr Kish has been practising echolocation since he was a child, after being blinded at just 13 months old by an aggressive form of eye cancer – and his talent has earnt him the nickname Batman. […]
The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin Cell Research advance online publication, January 5 2016. doi:10.1038/cr.2016.1 Authors: Susanne V Schmidt, Wolfgang Krebs, Thomas Ulas, Jia Xue, Kevin Baßler, Patrick Günther, Anna-Lena Hardt, Hartmut Schultze, Jil Sander, Kathrin Klee, Heidi Theis, Michael Kraut, Marc Beyer & Joachim L Schultze from […]
Sinus of Valsalva Sclerosis is Associated with Conduction Abnormalities on 12-Lead Standard ECG
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
The post Sinus of Valsalva Sclerosis is Associated with Conduction Abnormalities on 12-Lead Standard ECG appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PHUJpV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Why do Patients who Underwent Laparoscopic Adjustable Gastric Banding Surgery, Decide to Remove their Band, a Retrospective Cohort Study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
The post Why do Patients who Underwent Laparoscopic Adjustable Gastric Banding Surgery, Decide to Remove their Band, a Retrospective Cohort Study appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PHUHOO via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Presumed Primary Frozen Shoulder – Clinical Characteristics and Findings of Magnetic Resonance Imaging
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
The post Presumed Primary Frozen Shoulder – Clinical Characteristics and Findings of Magnetic Resonance Imaging appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1O2H7VT via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
A therapeutic cancer vaccine against GL261 murine glioma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Background: Glioblastoma (GBM) is the deadliest of brain tumors. Standard treatment for GBM is surgery, followed by combined radiation therapy and chemotherapy. Current therapy prolongs survival but does not offer a cure. We report on a novel immunotherapy against GBM, tested in an animal model of C57BL/6 mice injected intra-cranially with a lethal dose of […]
Issue Information – Table of Contents
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PKhcEI via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Orbital floor fractures – short- and intermediate-term complications depending on treatment procedures
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Background: Many reconstruction materials for orbital floor fractures have been described in the past including autologous bone transplants, resorbable polymers and titan meshes. So far evidence is missing which material is used successfully regarding indication and particular size of defect. Therefore the aim of this study was to evaluate which reconstruction technique produces best clinical […]
Executive Health Program at Cleveland Clinic
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Featuring Dr Lang: Cleveland Clinic Executive Health Program provides patients with a wide array of personalized options to enhance their health and well-being. The program is tailored to meet the needs of busy professionals and supports companies by optimizing the health of their executive teams. Posted at Clinical Cases and Images. Stay updated and subscribe, […]
Light/Dark Environmental Cycle Imposes a Daily Profile in the Expression of microRNAs in Rat CD133+ Cells
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract The phenotype of primary cells in culture varies according to the donor environmental condition. We recently showed that the time of the day imposes a molecular program linked to the inflammatory response that is heritable in culture. Here we investigated whether microRNAs (miRNAs) would show differential expression according to the time when cells were […]
Give patients direct access to physiotherapy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
You could say that parliament first approved the idea of direct access to physiotherapy in 1977, when it granted clinical autonomy to physiotherapists in the United Kingdom. Since the following year… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Pde0Nr via IFTTT
Chronic traumatic encephalopathy is reported in 25 year old former American football player
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
A 25 year old man who was repeatedly concussed while playing American football as an amateur and subsequently developed learning and behavioral problems has been found at autopsy to have chronic… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OJf8Oy via IFTTT
NHS choir’s number one hit puts health service in media spotlight over Christmas
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
“I’m sure more improbable things have happened, but I can’t think of any,” saidEddie Chaloner, a member of the Lewisham & Greenwich NHS Choir, which hit the top of the UK singles chart this Christmas… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OJfchc via IFTTT
Children born from infertility treatment are not at risk of developmental delays, study finds
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Children conceived after infertility treatment are no more likely to have developmental delays than children conceived naturally, researchers have reported in JAMA Pediatrics.1Concerns had arisen… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PHUNpH via IFTTT
Government “attack on local democracy” could undermine ethical and pro-health investing
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Proposals to change the rules on where local authorities can invest their pension funds could restrict decisions about disinvestment in what some councils see as unethical projects, particularly in… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1myp2WO via IFTTT
Probing the binding of procyanidin B3 to trypsin and pepsin: A multi-technique approach
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: April 2016 Source:International Journal of Biological Macromolecules, Volume 85 Author(s): Xiangrong Li, Mingjiang Geng Proanthocyanidins are a mixture of monomers, oligomers, and polymers of flavan-3-ols that are widely distributed in the plant kingdom. One of the most widely studied proanthocyanidins is procyanidin B3. In this study, the binding of procyanidin B3 to trypsin […]
Gene expression and molecular characterization of a chaperone protein HtpG from Bacillus licheniformis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: April 2016 Source:International Journal of Biological Macromolecules, Volume 85 Author(s): Hui-Fen Lo, Bo-En Chen, Min-Guan Lin, Meng-Chun Chi, Tzu-Fan Wang, Long-Liu Lin Heat shock protein 90 (Hsp90/HtpG) is a highly abundant and ubiquitous ATP-dependent molecular chaperone consisting of three flexibly linked regions, an N-terminal nucleotide-binding domain, middle domain, and a C-terminal domain. Here […]
