Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Τρίτη 25 Οκτωβρίου 2016

A multicenter, placebo-controlled, double-blind clinical trial assessing the effects of a multicomponent nutritional supplement for treating photoaged skin in healthy women

Summary

Background

Dietary or supplementary intake of nutrients and other ingredients positively affects skin appearance.

Aims

Evaluate a multicomponent nutritional supplement on photoaged skin.

Patients/Methods

This multicenter, double-blind, placebo-controlled trial randomized healthy 35- to 65-year-old women with Fitzpatrick skin types I–IV and Glogau classification types II–III to a multicomponent nutritional supplement or placebo for 24 weeks. The primary endpoint was Investigator Global Assessment of overall facial appearance at week 24. Secondary endpoints included investigator- and subject-rated assessments of the face, décolletage, and hands; facial photography assessments (conducted by an independent panel of dermatologists); and instrumental measures. Analysis of variance was used to assess between-group differences (P ≤ 0.05).

Results

Of 194 randomized subjects, 171 completed the study. Subjects had a mean age of 53 years and were primarily white (81%), had Glogau II (58%) and Fitzpatrick III (45%; significantly more supplement subjects had Fitzpatrick III [54%] vs. placebo [35%]; P = 0.039). At week 24, Investigator Global Assessment of overall facial appearance was numerically but not statistically better for supplement over placebo (mean difference: 0.14 [95% confidence interval: −0.16–0.44]; P = 0.358). A significant treatment-by-site interaction (P = 0.073) was observed; by-site analyses revealed a significant difference at one of three geographical sites for supplement vs. placebo (P = 0.001). Differences on secondary endpoints were generally not significant.

Conclusions

In the first multicenter study conducted with this multicomponent nutritional supplement, no significantly greater effects vs. placebo were observed on the primary endpoint, perhaps because of significant between-site variability.



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A text Message Alert System For Trained Volunteers Improves Out-of-Hospital Cardiac Arrest Survival



Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

Safety and efficacy of a combination of Paromomycin and Miltefosine for two versus three courses in patients with Post Kala-Azar Dermal Leishmaniasis (PKDL) - an observational pilot Study

PKDL is a dermal form of leishmaniasis caused by protozoal parasite Leishmania donovani. It is characterized by macular, popular and nodular lesions or a mixture of these1. It is mainly seen in Sudan and India, where it follows treatment of visceral leishmaniasis (VL) in 50% and 5-10% of cases respectively2. A phase III study on miltefosine-paromomycin combination for 10 days for treatment of Indian visceral leishmaniasis (n=157) revealed high cure rate (98.7%) with minimal toxicity, good compliance, lesser treatment duration and non-inferiority to standard amphotericin B3. We, therefore, aimed to assess the efficacy and safety of miltefosine plus paromomycin combination in thirty PKDL patients.

This article is protected by copyright. All rights reserved.



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Ultrasonographic Evaluation of Cervical Lymph Nodes in Thyroid Cancer

Objective

To determine what ultrasonographic features can identify metastatic cervical lymph nodes, both preoperatively and in recurrences after complete thyroidectomy.

Study Design

Prospective.

Setting

Outpatient clinic, Department of Head and Neck Surgery, School of Medicine, University of São Paulo, Brazil.

Subjects and Methods

A total of 1976 lymph nodes were evaluated in 118 patients submitted to total thyroidectomy with or without cervical lymph node dissection. All the patients were examined by cervical ultrasonography, preoperatively and/or postoperatively. The following factors were assessed: number, size, shape, margins, presence of fatty hilum, cortex, echotexture, echogenicity, presence of microcalcification, presence of necrosis, and type of vascularity. The specificity, sensitivity, positive predictive value, and negative predictive value of each variable were calculated. Univariate and multivariate logistic regression analyses were conducted. A receiver operator characteristic (ROC) curve was plotted to determine the best cutoff value for the number of variables to discriminate malignant lymph nodes.

Results

Significant differences were found between metastatic and benign lymph nodes with regard to all of the variables evaluated (P < .05). Logistic regression analysis revealed that size and echogenicity were the best combination of altered variables (odds ratio, 40.080 and 7.288, respectively) in discriminating malignancy. The ROC curve analysis showed that 4 was the best cutoff value for the number of altered variables to discriminate malignant lymph nodes, with a combined specificity of 85.7%, sensitivity of 96.4%, and efficiency of 91.0%.

Conclusion

Greater diagnostic accuracy was achieved by associating the ultrasonographic variables assessed rather than by considering them individually.



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Laryngotracheal Stenosis: Risk Factors for Tracheostomy Dependence and Dilation Interval

Objective

Laryngotracheal stenosis (LTS) is a fibrotic process that narrows the upper airway and has a significant impact on breathing and phonation. Iatrogenic injury from endotracheal and/or tracheostomy tubes is the most common etiology. This study investigates differences in LTS etiologies as they relate to tracheostomy dependence and dilation interval.

Study Design

Case series with chart review.

Setting

Single-center tertiary care facility.

Subjects and Methods

Review of adult patients with LTS was performed between 2004 and 2015. The association of patient demographics, comorbidities, disease etiology, and treatment modalities with patient outcomes was assessed. Multiple logistic regression analysis and Kaplan-Meier analysis were performed to determine factors associated with tracheostomy dependence and time to second procedure, respectively.

Results

A total of 262 patients met inclusion criteria. Iatrogenic patients presented with greater stenosis (P = .023), greater length of stenosis (P = .004), and stenosis farther from the vocal folds (P < .001) as compared with other etiologies. Iatrogenic patients were more likely to be African American, use tobacco, and have obstructive sleep apnea, type II diabetes, hypertension, chronic obstructive pulmonary disease, or a history of stroke. Iatrogenic LTS (odds ratio [OR] = 3.1, 95% confidence interval [95% CI] = 1.2-8.2), Cotton-Myer grade 3-4 (OR = 2.6, 95% CI = 1.1-6.4), and lack of intraoperative steroids (OR = 2.9, 95% CI = 1.2-6.9) were associated with tracheostomy dependence. Nonsmokers, patients without tracheostomy, and idiopathic LTS patients had a significantly longer time to second dilation procedure.

Conclusion

Iatrogenic LTS presents with a greater disease burden and higher risk of tracheostomy dependence when compared with other etiologies of LTS. Comorbid conditions promoting microvascular injury—including smoking, COPD, and diabetes—were prevalent in the iatrogenic cohort. Changes in hospital practice patterns to promote earlier tracheostomy in high-risk patients could reduce the incidence of LTS.



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Quality of Life after Sequential Bilateral Cochlear Implantation: An Updated Comprehensive Cochlear Implant Questionnaire

Objective

Assess psychometric properties of the Comprehensive Cochlear Implant Questionnaire (CCIQ) as a tool for assessing changes in health-related quality of life (HRQoL) after receiving a second cochlear implant (CI2).

Study Design

Prospective study.

Setting

Academic cochlear implant center.

Subjects and Methods

The CCIQ is a 29-item questionnaire assessing the physical and psychosocial benefits of a CI2 based on a 5-point Likert scale. The CCIQ was administered with the Nijmegen Cochlear Implant Questionnaire and the Short Form–12 Patient Questionnaire (SF-12) to patients with a CI2. Speech perception was tested with the consonant-nucleus-consonant (CNC) word test and AzBio test.

Results

Of 56 patients, 32 (57.1%) completed the instruments sent by mail. Of the 32 patients, 22 (68.8%) completed retest CCIQs 6 weeks later. CCIQ scores demonstrated significantly increased HRQoL in all domains. Internal consistency was very good overall (Cronbach's α = 0.90), with all subdomains exceeding an alpha value of 0.70. Test-retest reliability was good, with an overall intraclass correlation of 0.62. The CCIQ showed a moderate correlation with the Nijmegen Cochlear Implant Questionnaire and a low correlation with the SF-12. Average CNC and AZBio scores significantly improved by 31% ± 29% and 34% ± 33%, respectively. Audiometric data were not significantly correlated with the CCIQ.

Conclusion

The CCIQ shows (1) good reliability and evidence of construct validity, (2) a significant increase in HRQoL and significantly improved speech perception after CI2, and (3) greater sensitivity at detecting CI2 improvements to HRQoL. This promising measure is quick and easy to administer and provides subjective assessments of HRQoL specifically for those with a CI2.



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Readability Trends of Online Information by the American Academy of Otolaryngology--Head and Neck Surgery Foundation

Objective

Previous studies have shown that patient education materials published by the American Academy of Otolaryngology—Head and Neck Surgery Foundation may be too difficult for the average reader to understand. The purpose of this study was to determine if current educational materials show improvements in readability.

Study Design

Cross-sectional analysis.

Setting

The Patient Health Information section of the American Academy of Otolaryngology—Head and Neck Surgery Foundation website.

Subjects and Methods

All patient education articles were extracted in plain text. Webpage navigation, references, author information, appointment information, acknowledgments, and disclaimers were removed. Follow-up editing was also performed to remove paragraph breaks, colons, semicolons, numbers, percentages, and bullets. Readability grade was calculated with the Flesch-Kincaid Grade Level, Flesch Reading Ease, Gunning-Fog Index, Coleman-Liau Index, Automated Readability Index, and Simple Measure of Gobbledygook. Intra- and interobserver reliability were assessed.

Results

A total of 126 articles from 7 topics were analyzed. Readability levels across all 6 tools showed that the difficulty of patient education materials exceeded the abilities of an average American. As compared with previous studies, current educational materials by the American Academy of Otolaryngology—Head and Neck Surgery Foundation have shown a decrease in difficulty. Intra- and interobserver reliability were both excellent, with intraclass coefficients of 0.99 and 0.96, respectively.

Conclusion

Improvements in readability is an encouraging finding and one that is consistent with recent trends toward improved health literacy. Nevertheless, online patient educational material is still too difficult for the average reader. Revisions may be necessary for current materials to benefit a larger readership.



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The Value of Tumor Diameter in Predicting Prognosis of Nasopharyngeal Carcinoma Treated with Intensity-Modulated Radiotherapy

Objective

The tumor, node, and metastasis staging system of nasopharyngeal carcinoma (NPC) has limitations in predicting prognosis. The aim of this study was to explore the prognostic value of tumor diameter for patients with NPC who were treated with intensity-modulated radiotherapy.

Study Design

Case series with chart review.

Setting

Affiliated Cancer Hospital of Guangxi Medical University.

Subjects and Methods

The cases of 137 NPC patients treated with intensity-modulated radiotherapy were retrospectively reviewed. Tumor diameter was measured on pretreatment magnetic resonance images. Receiver operating characteristic curve was used to find the optimal cutoff value of tumor diameter and to examine the predictive ability of tumor diameter combined with T classification.

Results

The mean tumor diameter increased with the advancing of T classification. The 5-year cumulative survival rates for patients with a tumor diameter <43 mm vs ≥43 mm were 88.4% vs 61.8% (P < .001), respectively. In multivariate analysis, tumor diameter was an independent prognostic factor for 5-year cumulative survival. For patients with T3 + T4, the 5-year cumulative survival rate was higher in the group with a tumor diameter <43 mm vs ≥43 mm (86.2% vs 60.2%, P = .022). The area under the receiver operating characteristic curve was 70.3% for tumor diameter combined with T classification, superior to T classification (area under the curve = 66.2%).

Conclusion

Tumor diameter may be related to the extent of tumor invasion and can provide important information on prognosis. The incorporation of 43 mm as a cutoff value of tumor diameter may help to refine the predictive power of the current staging system for NPC.



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Treatment of Chronic Cough: Single-Institution Experience Utilizing Behavioral Therapy

Objective

Chronic cough remains a challenging condition, especially in cases where it persists despite comprehensive medical management. For these particular patients, there appears to be an emerging role for behavior modification therapy. We report a series of patients with refractory chronic cough to assess if there is any benefit of adding behavioral therapy to their treatment regimen.

Study Design

A case series with planned chart review of patients treated for chronic cough.

Setting

The review was performed with an outpatient electronic health record system at a tertiary care center.

Subjects and Methods

The charts of all patients treated for chronic cough by a single laryngologist over a 30-month period were analyzed. Patients' response to treatment and rate of cough improvement were assessed for those with refractory chronic cough who underwent behavior modification therapy.

Results

Thirty-eight patients with chronic cough were initially treated empirically for the most common causes of cough, of which 32% experienced improvement. Nineteen patients who did not significantly improve with medical management underwent behavior modification therapy with a speech-language pathologist. Of these patients, 84% experienced resolution or marked improvement of their symptoms.

Conclusion

Behavioral therapy may be underutilized in practice and could lead to improvement of otherwise recalcitrant cough.



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A Retrospective Cohort Study of Glossopharyngeal Nerve Taste in Children with Recurrent Acute Tonsillitis

Objective

To compare glossopharyngeal taste between healthy children and those with recurrent acute tonsillitis.

Study Design

Retrospective cohort study.

Setting

Pediatric clinics in a tertiary care medical center and satellite location.

Subjects and Methods

Smell and taste testing was administered to 80 well children and 64 children with recurrent acute tonsillitis (age range, 6-17 years). Smell testing was performed with the NIH Toolbox Odor Identification Test, with scores based on national averages for age and sex. Validated Taste Strips were placed on the midline of the tongue at the circumvallate papillae in random tastant order and in increasing concentrations to test sweet, salty, sour, and bitter. Ordinal logistic regression was used for multivariate analysis.

Results

The healthy and tonsillitis groups were similar, with mean ages of 11.3 and 10.8 years (P = .34), respectively. The tonsillitis group had fewer boys (n = 18 vs 43, P = .002), higher mean body mass index (BMI) percentile (n = 72.2 vs 59.8, P = .01), and more subjects with public or no insurance (n = 24 vs 13, P = .004). Univariate analysis revealed no statistically significant differences in rate of normal overall taste (67.2% vs 60%, P = .39) and in sweet (79.7% vs 82.5%, P = .67), salty (85.9% vs 82.8%, P = .82), sour (64.1% vs 70%, P = .48), and bitter (90.6% vs 86.3%, P = .45). In multivariate analysis, smell ability, sex, BMI percentile, parent BMI, and insurance type did not affect overall taste or sweet, salty, sour, or bitter alone.

Conclusion

Despite controlling for potential intrinsic (sex, smell, BMI) and extrinsic (parent BMI, insurance type) confounders, there was no statistically significant difference in taste among children with recurrent acute tonsillitis as compared with healthy children.



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Are All Manikins Created Equal? A Pilot Study of Simulator Upper Airway Anatomic Fidelity

This study evaluates the anatomic fidelity of several commercially available pediatric and adult manikins, including airway task trainers, which could be used in aerodigestive procedure training. Twenty-three experienced otolaryngologists assessed the aerodigestive anatomy of 5 adult and 5 pediatric manikins in a passive state, using rigid and flexible endoscopy. Anatomic fidelity was rated on a 5-point scale for the following: nasal cavity, nasopharynx, oral cavity, oropharynx, larynx, trachea, esophagus, and neck. Mean scores and standard deviations were tabulated for each manikin at each anatomic site. Ratings by survey participants demonstrated variation in the anatomic fidelity of the aerodigestive tract in a range of manikins. Radar chart display of the results allows comparison of manikin fidelity by anatomic site. Differences in scores may allow instructors to select manikins with the best anatomic fidelity for specific educational purposes, and they may contribute to recommendations to improve future manikin design.



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False Vocal Fold Characteristics in Presbylarynges and Recurrent Laryngeal Neuropathy

Objective:

Conflicting data exist regarding false vocal fold (FVF) anatomy; it is unclear if this structure is an extension of the thyroarytenoid muscle or an independent muscle system. This confusion is amplified by diverse clinical findings in the setting of unilateral recurrent laryngeal neuropathy and presbylarynges. We sought to characterize FVF behavior in these contexts.

Methods:

Laryngoscopic/stroboscopic examinations from 11 patients with unilateral recurrent laryngeal nerve paresis and 12 patients with presbylarynges were reviewed by 4 laryngologists, blinded to the goal of the study but informed of diagnosis. Variables related to FVF structure and function at rest and during phonation were rated.

Results:

In recurrent laryngeal neuropathy, no significant association between atrophic/paretic vocal fold (VF) and FVF size was observed at rest (P = .69). During phonation, FVF compression was noted bilaterally; contralateral FVF hypertrophy was more common (P = .002). In presbylarynges, neither FVF size at rest (P = .86) nor compression during phonation (P = .37) was associated with the more atrophic VF; FVF compression/hypertrophy was common.

Conclusions:

Consistent with clinical dogma, FVF compression was more common contralateral to VF neuropathy. This finding, however, was inconsistent and may suggest individual variability in FVF innervation and/or morphology. Intra- and interrater reliability of these clinical findings was poor.



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Measuring Oxidative DNA Damage With 8-Hydroxy-2-Deoxyguanosine Levels in Patients With Laryngeal Cancer

Objectives:

8-Hydroxy-2'-deoxyguanosine is a biomolecule associated with DNA damage. We evaluated oxidative stress and DNA damage in patients with laryngeal cancer by measuring 8-hydroxy-2'-deoxyguanosine levels.

Methods:

This study enrolled 117 subjects, including 64 controls and 53 patients who had benign vocal cord lesions or laryngeal cancer. The benign excised lesions, tumor tissue, noncancerous laryngeal tissue, blood, and urine were subjected to high-performance liquid chromatography, and 8-hydroxy-2'-deoxyguanosine levels were compared between groups.

Results:

Blood and urine 8-hydroxy-2'-deoxyguanosine levels in patients with laryngeal carcinoma were significantly higher than in the controls (P = .00002, P = .00001). The 8-hydroxy-2'-deoxyguanosine level was significantly higher in tumor tissues than in non-tumor tissue and benign vocal cord lesion tissues (P = .00002, P = .000001).

Conclusions:

We determined that laryngeal cancer was associated with oxidative stress, which may be quantified by measuring 8-hydroxy-2'-deoxyguanosine. For a patient with a suspicious laryngeal lesion, 8-hydroxy-2'-deoxyguanosine levels in blood and urine can provide advance information about the likely diagnosis.



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Benign Paroxysmal Positional Vertigo Secondary to Mild Head Trauma

Objectives:

We studied the clinical characteristics, nystagmographic findings, and treatment outcome of a group of patients with benign paroxysmal positional vertigo (BPPV) secondary to mild head trauma and compared them with a group of patients with idiopathic BPPV.

Methods:

The medical records of 33 patients with BPPV associated with mild head trauma were reviewed. Data of a complete otolaryngological, audiological, neurotologic, and imaging evaluation were available for all patients. Three hundred and twenty patients with idiopathic BPPV were used as a control group.

Results:

The patients with BPPV secondary to mild head trauma presented the following features, in which they differed from the patients with idiopathic BPPV: (1) lower mean age, with more intense symptoms; (2) increased rate of horizontal and anterior semicircular canal involvement and frequent multiple canal and bilateral involvement; (3) greater incidence of canal paresis and presence of spontaneous nystagmus; (4) poorer treatment results, attributed mainly to coexisting canal paresis in many patients, and higher rate of recurrence.

Conclusions:

Benign paroxysmal positional vertigo associated with mild head trauma differs from idiopathic BPPV in terms of several epidemiological and clinical features; it responds less effectively to treatment and is prone to recurrence.



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Radiological and NRT-Ratio-Based Estimation of Slim Straight Cochlear Implant Electrode Positions: A Multicenter Study

Objectives:

An intraoperative neural response telemetry-ratio (NRT-ratio) was established, which can provide information about the intraoperative intracochlear electrode array position for perimodiolar electrodes.

Methods:

In a retrospective controlled study in 2 tertiary referral centers, the electrophysiological data sets of 50 patients with measured intraoperative auto-NRTs and postoperative radiological examinations were evaluated. All patients were implanted with Nucleus slim straight electrodes. The NRT-ratio was calculated by dividing the average auto-NRT data from electrodes 16 to 18 with the average from electrodes 5 to 7. Using a flat panel tomography system or a computed tomography, the position of the electrode array was certified radiological.

Results:

Radiologically, 2 out of 50 patients were identified with an electrode translocated from the scala tympani into the scala vestibuli. The radiologically estimated electrodes indicating a scalar change showed a regular NRT-ratio but nonspecific NRT-level changes at the localization of translocation.



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Role of endoscopic guided partial adenoidectomy in avoiding open nasality

Publication date: November 2016
Source:Egyptian Journal of Ear, Nose, Throat and Allied Sciences, Volume 17, Issue 3
Author(s): Eman Mostafa, Ibrahim Rezk
ObjectivesAssess the effects of endoscopic guided partial adenoidectomy on resonance of speech in patients with poor palatal mobility and evaluate its role in avoiding postoperative open nasality.Materials and methodsThis study was a prospective randomized trial conducted in one year duration. A total of 40 patients were assessed for eligibility; 24 patients were excluded as they did not meet the inclusion criteria. Two patients out of the eligible sixteen refused surgery. Inclusion criteria: 1-patient complaining of snoring, nasal obstruction and nasal discharge, all of which were caused by adenoid. 2-Poor palatal mobility on endoscopic examination. Exclusion criteria: any neurological deficit, muscular disorder or structural defects of the palate. All eligible patients had undergone partial adenoidectomy. Speech was evaluated preoperative and postoperative.ResultsThe study group had definite poor palatal mobility on endoscopic examination and lateral videofluroscopy. Endoscopic guided partial adenoidectomy has been done to all 14 patients. Postoperative evaluation showed marked relieving of symptoms such as nasal obstruction, discharge and mouth breathing with successfully maintaining the velopharyngeal competence but there was no complete relieving of closed nasality.ConclusionThere is necessity to screen potential candidates for adenoidectomy in order to prevent postoperative velopharyngeal dysfunction. Nasoendoscopy and lateral videofluroscopy have been useful to examine the palatal mobility, palatal length, depth of the pharynx and to exclude possible occult cleft palate. Partial adenoidectomy should be taken into consideration for risky patients. Satisfactory results were obtained as regards relieving nasal symptoms and maintaining velopharyngeal competence but didn't improve quite fully the closed nasality.



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Editorial Board

Publication date: November 2016
Source:Egyptian Journal of Ear, Nose, Throat and Allied Sciences, Volume 17, Issue 3





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EMS use of CPAP for respiratory emergencies

The use of continuous positive airway pressure, commonly called CPAP, for the emergency management of congestive heart failure is rapidly becoming the new standard of care, replacing the traditional approaches of nitrates, diuretics and invasive airway management. As CPAP becomes more commonplace, more uses for the technology have emerged.

Positive pressure: a brief review
We covered the basic physiologic principles in the use of CPAP previously. As you might remember from your initial training, the exchange of carbon dioxide and oxygen gases occurs within the lung's alveoli. The walls of each alveolus is very thin, in order for the red blood cells to pick up oxygen molecules from each inspiration and for carbon dioxide to be released from the bloodstream during each exhalation.

Within the alveolus is a liquid called surfactant, which reduces water surface tension within the space and keeps the alveolus open. Excess fluid from heart failure will disturb this balance, causing the alveoli to collapse and gas exchange to be compromised.

CPAP forces a small amount of air pressure through the pulmonary tree and into the alveoli, causing them to reopen. Additionally, the increased intrathoracic pressure will also reduce the patient's hypertensive state, allowing the fluid shift to occur more easily.

The pressure created by CPAP is held constant throughout the breathing cycle; the patient will feel a small amount of "back pressure" during the exhalation phase.

Mainstay of heart failure treatment
The main use of CPAP in the field care setting is for the management of heart failure secondary to pulmonary hypertension. It has been shown to be highly effective in reducing the length of stay in hospitals and the overall cost of care to the patient.

It remains important to carefully monitor a patient's blood pressure prior to and during CPAP treatment. CPAP is not indicated for pulmonary edema secondary to cardiogenic shock.

Additionally, patients must be able to follow simple commands and have adequate ventilation ability in order to use CPAP.

Other uses for CPAP 
EMS providers, depending on their local protocols, need to be aware of these additional uses for CPAP.

1. Bronchoconstriction
CPAP has been shown to be effective in managing asthma and COPD in patients in moderate to severe distress. It's believed that a combination of forcing the small bronchioles to open and allowing trapped air to be released from the alveoli provides relief from the acute event.

Several CPAP devices also allow bronchodilator medications to be nebulized and administered simultaneously with consistent and continuous positive pressure. Evaluate your CPAP supplies because an integrated nebulizer port is an additional feature and not available on every system.

2. Toxic inhalation
Several types of toxic gas, such as chlorine, can irritate and injure lower airway tissue, causing swelling, bronchospasm and noncardiogenic pulmonary edema.

Even larger airways, such as the main bronchioles, can be affected by smoke and other combustion byproducts.CPAP may offer relief in these situations.

3. Drowning
Water inhaled into the lungs during a drowning episode can cause atelectasis (collapse of the alveoli) and pulmonary edema. Water aspiration can worsen the ability of the lung tissue to exchange gases. There is some evidence that CPAP in these circumstances improves gas exchange.

4. Flail chest
Small studies have indicated that a patient with a significant flail chest can be safely managed with CPAP and pain control. In a flail chest, the ability to create adequate chest rise during inhalation is compromised through an unstable rib cage and significant pain.

Positive pressure ventilation through a bag-mask device requires training and careful use with such a spontaneously breathing patient. CPAP may provide better control of tidal volume in these circumstances.

5. Lung infections
Pneumonia and other infections in the lung can create a pulmonary-ventilation mismatch, where oxygen and carbon dioxide are unable to pass freely through the alveolar-capillary membrane.

CPAP appears to help improve gas diffusion in these cases, possibly by reducing inflammation of the cells and improving airflow to the alveoli.

Summary
There are several states that permit basic EMTs to use CPAP within their scope of practice, including Illinois, Wisconsin and North Dakota. CPAP has been found to be safe to use, and it's easy to train and retain the information for CPAP.

Our understanding of CPAP and its uses in emergency field care will continue to expand as the technology develops and research continues. It will also become more widespread as the devices become less expensive.

It's clear that its use in heart failure is highly effective, giving the EMS provider a valuable tool in efforts to deliver high-quality care.

But there are other conditions that also appear to benefit from CPAP, making it a versatile technique to deploy quickly and easily in the field.

References

1.      Brett A., Sinclair DG. Use of continuous positive airway pressure in the management of community acquired pneumonia. Thorax. 1993; 48(12): 1280–1281.

2.      Bruge P., Jabre P., Dru M., et al. An observational study of noninvasive positive pressure ventilation in an out-of-hospital setting. Am J Emerg Med. 2008; 26:165–9.

3.      Cosentini R, Brambilla AM, Aliberti S, et al. Helmet continuous positive airway pressure vs. oxygen therapy to improve oxygenation in community-acquired pneumonia: A randomized, controlled trial. Chest. 2010; 138:114–120.

4.      Davies LK, Poulton TJ, Modell JH. Continuous positive airway pressure is beneficial in treatment of smoke inhalation. Crit Care Med. 1983; 11:726–729.

5.      Gunduz M, Unlugenc H, Ozalevli M, et al. A comparative study of continuous positive airway pressure (CPAP) and intermittent positive pressure ventilation (IPPV) in patients with flail chest. Emerg Med J. 2005; 22:325–329.

6.      Hubble MW, Richards ME, Jarvis R., Millikan T., Young D. Effectiveness of prehospital continuous positive airway pressure in the management of acute pulmonary edema. Prehosp Emerg Care. 2006;10: 430–9.

7.      Miller K, Chang A. Acute inhalation injury. Emerg Med Clin North Am. 2003;21: 533–557.

8.      Kallio T., Kuisma M., Alaspaa A., Rosenberg PH. The use of prehospital continuous positive airway pressure treatment in presumed acute severe pulmonary edema. Prehosp Emerg Care. 2003;7: 209–13.



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A Comprehensive Analysis on the Association between Tobacco-Free Betel Quid and Risk of Head and Neck Cancer in Taiwanese Men

by Yuan-Hua Wu, Chia-Jui Yen, Jenn-Ren Hsiao, Chun-Yen Ou, Jehn-Shyun Huang, Tung-Yiu Wong, Sen-Tien Tsai, Cheng-Chih Huang, Wei-Ting Lee, Ken-Chung Chen, Sheen-Yie Fang, Jiunn-Liang Wu, Wei-Ting Hsueh, Forn-Chia Lin, Ming-Wei Yang, Jang-Yang Chang, Hsiao-Chen Liao, Shang-Yin Wu, Chen-Lin Lin, Yi-Hui Wang, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen, Jeffrey S. Chang

Objectives

Although betel quid (BQ) is an established risk factor of head and neck cancer (HNC), insufficiencies exist in the literature regarding the dose-response, BQ types, HNC sites, and BQ cessation. The current study was conducted to fill these insufficiencies.

Materials and Methods

A hospital-based case-control study was conducted to evaluate the association between BQ and HNC. In-person interview was conducted to collect data on BQ chewing. The current analysis included 487 men newly diagnosed with HNC and 617 male controls who were frequency-matched to the cases by age. The association between BQ and HNC was assessed using multivariable unconditional logistic regression.

Results

Ever BQ chewing was associated with an increased HNC risk regardless of the BQ types. A non-linear positive association between BQ and HNC was observed, with a steep rise in HNC risk for the first 5 pack-years or 200,000 minutes of BQ consumption. Every year of BQ cessation was associated with a 2.9% reduction in HNC risk; however, the risk did not reduce to the level of non-BQ chewers even after 20 years of BQ cessation. Eliminating BQ chewing may prevent 51.6% of HNCs, 62.6% of oral cancers, and 41.3% of pharyngeal cancers in Taiwan.

Conclusion

Our results supported the positive association between BQ and HNC. BQ cessation is effective in reducing HNC risk and should be encouraged. Because BQ cessation may not reduce the HNC risk to the level of non-BQ chewers, it is important to prevent the initiation of BQ chewing.



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LIM-Only Protein 4 (LMO4) and LIM Domain Binding Protein 1 (LDB1) Promote Growth and Metastasis of Human Head and Neck Cancer (LMO4 and LDB1 in Head and Neck Cancer)

by Elizabeth A. Simonik, Ying Cai, Katherine N. Kimmelshue, Dana M. Brantley-Sieders, Holli A. Loomans, Claudia D. Andl, Grant M. Westlake, Victoria M. Youngblood, Jin Chen, Wendell G. Yarbrough, Brandee T. Brown, Lalitha Nagarajan, Stephen J. Brandt

Squamous cell carcinoma of the head and neck (HNSCC) accounts for more than 300,000 deaths worldwide per year as a consequence of tumor cell invasion of adjacent structures or metastasis. LIM-only protein 4 (LMO4) and LIM-domain binding protein 1 (LDB1), two directly interacting transcriptional adaptors that have important roles in normal epithelial cell differentiation, have been associated with increased metastasis, decreased differentiation, and shortened survival in carcinoma of the breast. Here, we implicate two LDB1-binding proteins, single-stranded binding protein 2 (SSBP2) and 3 (SSBP3), in controlling LMO4 and LDB1 protein abundance in HNSCC and in regulating specific tumor cell functions in this disease. First, we found that the relative abundance of LMO4, LDB1, and the two SSBPs correlated very significantly in a panel of human HNSCC cell lines. Second, expression of these proteins in tumor primaries and lymph nodes involved by metastasis were concordant in 3 of 3 sets of tissue. Third, using a Matrigel invasion and organotypic reconstruct assay, CRISPR/Cas9-mediated deletion of LDB1 in the VU-SCC-1729 cell line, which is highly invasive of basement membrane and cellular monolayers, reduced tumor cell invasiveness and migration, as well as proliferation on tissue culture plastic. Finally, inactivation of the LDB1 gene in these cells decreased growth and vascularization of xenografted human tumor cells in vivo. These data show that LMO4, LDB1, and SSBP2 and/or SSBP3 regulate metastasis, proliferation, and angiogenesis in HNSCC and provide the first evidence that SSBPs control LMO4 and LDB1 protein abundance in a cancer context.

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Inflammatory bowel disease is associated with an increased risk of inflammatory skin diseases: A population-based cross-sectional study

Inflammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract attributed to aberrant activity of the immune system. Increasing evidence suggests that patients with IBD are at an increased risk of inflammatory skin diseases (ISDs).

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Inflammatory bowel disease is associated with hidradenitis suppurativa: Results from a multicenter cross-sectional study

Hidradenitis suppurativa (HS) is often associated with inflammatory bowel disease (IBD; Crohn's disease or ulcerative colitis). However, the prevalence of IBD in HS patients is unknown.

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Dermoscopic patterns of fungal melanonychia: A comparative study with other causes of melanonychia

Diagnosing fungal melanonychia (FM) is often difficult because it mimics melanonychia caused by other factors. Dermoscopy is helpful in the setting of nail pigmentation. However, the diagnostic characteristics of FM on dermoscopy are not fully elucidated.

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Selected Literature Watch

Violence and Gender , Vol. 0, No. 0.


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What Role Does Allergy Play in Chronic Ear Disease and Laryngitis?

Abstract

IgE-mediated allergy plays a well-established role in both nasal and pulmonary diseases due to the common epithelium and shared mediator responses of the upper and lower airways. This "unified airway" concept has also been described in other sites within the head and neck that contain similar respiratory mucosa: the middle ear and the larynx. This review will highlight the data suggesting a role for IgE-mediated allergic disease in chronic laryngopharyngeal and middle ear disease and the role for allergy testing to aid in diagnosis and treatment of these disorders.



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Circulating 3-T1AM and 3,5-T2 in Critically Ill Patients: A Cross-Sectional Observational Study

Thyroid , Vol. 0, No. 0.


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Congenital nasal cavity stenosis in children with craniosyntosis: A report of 4 rare cases

Congenital bony nasal stenosis (CBNS) is a very rare but life-threatening cause of airway obstruction in neonates and infants. This review aims to assess the presentation and early airway management of 4 new cases of craniosynostosis with bilateral nasal cavity stenosis. Patients were treated with endoscopic endonasal widening of the nasal cavity and stenting. All patients were extubated well post-operatively with resolution of symptoms. They remained asymptomatic with stents in situ for at least 6 months with no complications reported.

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The Use of Computerised Simulation for the Training of Endoscopic Sinus Surgery

Abstract

Purpose of Review

This review summarises the progress made in the development of computer–based simulation for the training of endoscopic sinus surgery. What are the current limitations of available simulators? What does the future hold for such technology?

Recent Findings

Advances in three-dimensional image processing and highly customisable programming platforms have meant that realistic, haptic feedback enabled, computerised virtual reality simulators are now available. Several simulators have now been validated using scientific methodology. Fidelity of these simulators largely varies from high to low and evidence is lacking as to what the level of fidelity plays in the overall usefulness of a simulator. The range of surgical techniques able to be performed remains limited and introducing anatomical variables remains a challenge within this field.

Summary

Whilst computerised simulation for training endoscopic sinus surgery has made major advances in the last decade, it still has significant limitations. Improvements in haptic removal of sinus tissue, introduction of variable anatomy and bleeding simulation may allow greater acceptance of this technology in the future.



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Olanzapin



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Knochen- und Weichteilsarkome des Kindes-, Jugend- und jungen Erwachsenenalters

Zusammenfassung

Hintergrund

Primäre maligne Sarkome des Kindes-, Jugend- und jungen Erwachsenenalter sind selten und stellen die behandelnden Ärzte vor enorme Herausforderungen.

Ziel

Ziel der Arbeit ist es, einen Überblick über die typischen Sarkomerkrankungen des Kindes-, Jugend- und jungen Erwachsenenalters zu geben. Der Artikel vermittelt eine Übersicht über Epidemiologie, klinische Präsentation, Tumorbiologe, internationale Therapiestrategien und aktuelle Phase-I-, -II- und –III- Studien.

Material und Methoden

Die Arbeit basiert auf selektiver Literaturrecherche und Daten aus den eigenen nationalen und internationalen Studiengruppen.

Ergebnisse

Die Therapie verlangt eine enge Kooperation vieler Disziplinen, da das Therapiekonzept von malignen Sarkomen bei diesen Patienten ein unabdingbar multimodales ist. Durch die Einführung einer kombinierten Behandlung aus Chemotherapie, Operation und/oder Strahlentherapie haben heute zwei Drittel der Patienten die Chance auf Heilung. Wesentliche Voraussetzung für eine kurative Therapie ist hierbei, dass diese frühzeitig beginnt, der Tumor früh erkannt wird und die Behandlung durch ein erfahrenes Team durchgeführt wird.



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Effect of curcumin on nasal symptoms and airflow in patients with perennial allergic rhinitis

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Publication date: Available online 24 October 2016
Source:Annals of Allergy, Asthma & Immunology
Author(s): Sihai Wu, Dajiang Xiao
BackgroundAllergic rhinitis (AR) is a common disorder that can significantly affect patient quality of life. Previous studies have found that curcumin had anti-inflammatory and antioxidant effects and clinical benefits in cancer and asthma.ObjectiveTo determine the efficacy of curcumin in the treatment of AR and to explore the molecular mechanisms involved.MethodsIn a randomized, double-blind study, 241 patients with AR received either placebo or oral curcumin for 2 months. The therapeutic effects of curcumin were evaluated by nasal symptoms and nasal airflow resistance. In addition, the production of interferon γ, interleukin (IL) 4, IL-10, and tumor necrosis factor α from mononuclear cells and IL-8, soluble intercellular adhesion molecule, polyethylene glycol 2, and leukotriene C4 from polymorphonuclear neutrophils were compared before and after curcumin treatment.ResultsCurcumin alleviated nasal symptoms (sneezing and rhinorrhea) and nasal congestion through reduction of nasal airflow resistance. Curcumin was found to exert diverse immunomodulatory effects, including suppression of IL-4, IL-8, and tumor necrosis factor α and increased production of IL-10 and soluble intercellular adhesion molecule. However, curcumin did not affect the release of prostaglandin E2 and leukotriene C4 from polymorphonuclear neutrophils.ConclusionThis pilot study provides the first evidence of the capability of curcumin of improving nasal airflow and modulating immune response in patients with AR.



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Sugammadex

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Publication date: Available online 24 October 2016
Source:Annals of Allergy, Asthma & Immunology
Author(s): Kok Loong Ue, Bogusia Kasternow, Annette Wagner, Ryszard Rutkowski, Krzysztof Rutkowski




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Is the association between exhaled nitric oxide and asthma symptoms altered by body weight in rural adolescents?

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Publication date: Available online 24 October 2016
Source:Annals of Allergy, Asthma & Immunology
Author(s): Stephen F. Dinetz, Jennifer L. Waller, Martha S. Tingen




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Interactive effects between obesity and atopy on inflammation

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Publication date: Available online 24 October 2016
Source:Annals of Allergy, Asthma & Immunology
Author(s): Jing Zheng, Xin Zhang, Li Zhang, Hong Ping Zhang, Lei Wang, Gang Wang




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High-efficiency lysis of cervical cancer by allogeneic NK cells derived from umbilical cord progenitors is independent of HLA status

Abstract

Down-regulation of HLA in tumor cells, low numbers and dysfunctionality of NK cells are commonly observed in patients with end-stage cervical cancer. Adoptive transfer of high numbers of cytotoxic NK cells might be a promising treatment approach in this setting. Here, we explored the cytotoxic efficacy on ten cervical cancer cell lines of activated allogeneic NK cells from two sources, i.e., peripheral blood (PBNK) with and without cetuximab (CET), a tumor-specific monoclonal antibody directed against EGFR, or derived from umbilical cord blood (UCB-NK). Whereas CET monotherapy was ineffective against the panel of cervical cancer cell lines, irrespective of their EGFR expression levels and despite their RAS wt status, it significantly enhanced the in vitro cytotoxic efficacy of activated PBNK (P = 0.002). Equally superior cytotoxicity over activated PBNK alone was achieved by UCB-NK (P < 0.001). Both PBNK- and UCB-NK-mediated cytotoxic activity was dependent on the NK-activating receptors natural killer group 2, member D receptor (NKG2D) and DNAX accessory molecule-1 (DNAM-1) (P < 0.05) and unrelated to expression levels of the inhibitory receptors HLA-E and/or HLA-G. Most strikingly, whereas the PBNK's cytotoxic activity was inversely correlated with HLA-ABC levels (P = 0.036), PBNK + CET and UCB-NK cytotoxicity were entirely independent of HLA-ABC expression. In conclusion, this study provides a rationale to initiate a clinical trial for cervical cancer with adoptively transferred allogeneic NK cells, employing either UCB-NK or PBNK + CET for EGFR-expressing tumors. Adoptive transfer of UCB-NK might serve as a generally applicable treatment for cervical cancer, enabled by HLA-, histology- and HPV-independent killing mechanisms.



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Grisel Syndrome in Otolaryngology: A Case Series with Literature Review

Abstract

Grisel's syndrome is non traumatic atlanto axial subluxation usually associated with inflammatory conditions of head and neck region. Non traumatic atlanto axial joint subluxation is a rare entity for an unsuspecting otolaryngologist. The condition if missed and not treated properly can have serious implications with possible neurological deficit. We attempt to review the existing literature on the disease condition and also to highlight the proper management of the condition. Retrospective analysis of hospital record of last five years and an internet based literature survey on the current concepts and management of the condition. We have come across five cases of Grisel's syndrome over the last five years. The clinicopathological and radiological features are described. Grisel syndrome may remain undiagnosed at initial presentation if not suspected. Delayed diagnosis may result in life long morbidity for the patient and the need for surgical intervention. Many of the early cases can be treated successfully by conservative approach.



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Intravenous thrombolysis in a patient taking warfarin with an international normalised ratio of 1.9

Intravenous thrombolysis is the mainstay medical treatment for acute ischaemic strokes, but has strict eligibility criteria. Symptomatic intracranial haemorrhage (sICH) is the most adverse complication. A woman aged 76 years presented with signs of an acute stroke and despite not meeting the eligibility criteria, given her background use of warfarin, she received intravenous thrombolysis with an excellent outcome. This is the first fully documented case report of the contraindicated use of intravenous thrombolysis in a patient presenting with an acute ischaemic stroke on a background of concurrent use of warfarin with an international normalised ratio (INR) as high as 1.9. It has been perceived that the risk of thrombolysis with a raised INR outweighs the potential benefits. However, documenting its use outside of the current eligibility criteria is key to future developments.



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Paraurethral cysts in newborn girls

The Skene's glands are located in the distal urethral floor, and they are the largest paraurethral glands. Skene's gland cysts are unusual at any age, but specially newborns. However, due to lack of systematic reporting, true incidence is probably higher than the one described in the literature. We present a newborn girl found to have a paraurethral cyst at birth. Characteristic displacement of the urethral opening was revealed on catheterisation. Review of literature, and comparison to a similar case of interlabial mass previously evaluated, were carried out. We suggest a prenatal development possibly due to maternal oestrogen exposure, although further studies are necessary to determine the exact aetiology. Treatment options include observation, needle aspiration and incisional drainage, partial excision, unroofing and marsupialisation. Expectant management is preferred in asymptomatic cases, particularly in newborns, since spontaneous resolution can occur without long-term sequalae or recurrence. Cases with acute obstruction require immediate surgical management.



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Ventricular fibrillation via torsade des pointes of cardiac sarcoidosis with preserved left ventricular ejection fraction

Generally, low left ventricular ejection fraction (LVEF) is a risk for ventricular arrhythmia in patients with cardiac sarcoidosis. We present a case of cardiac sarcoidosis with preserved LVEF that evoked ventricular fibrillation (VF). A 73-year-old woman with VF presented to our emergency department. She had a history of ocular sarcoidosis, with gradual thinning of the basal intraventricular septum. LVEF was 62% on the most recent echocardiography. The electrocardiogram after defibrillation showed complete atrioventricular block (CAVB) with QT segment prolongation and frequent ventricular premature beats. VF via torsade des pointes (TdP) was suspected, and temporary intravenous ventricular pacing and magnesium sulfate infusion suppressed her VF. Cardiac sarcoidosis was diagnosed, and an implantable cardioverter defibrillator was implanted. Patients with cardiac sarcoidosis with CAVB are at risk of evoking VF via TdP regardless of LVEF. If cardiac sarcoidosis is suspected, early diagnosis and risk stratification of ventricular arrhythmia are important.



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Urethral leiomyoma: a rare case of voiding difficulty

Description

A woman aged 28 years presented with a history of voiding difficulty with straining on micturition for 2 months. She was completely asymptomatic and had no symptoms of voiding difficulty prior to this. On physical examination, she was found to have a firm tender mass measuring 2.5x2 cm, involving the posterior periurethral region. The urethral orifice could not be separately identified. Uroflowmetry was performed and was within the normal limit. Transperineal ultrasound revealed a well-defined homogeneously hypoechoic solid lesion anterior to the vagina. The posterior urethral wall could not be separately delineated from the lesion. On colour Doppler interrogation, the lesion showed significant internal vascularity (figure 1). There was no significant postvoid residue. MRI was performed for further characterisation of the lesion and its relation to adjacent structures. Axial, coronal and sagittal T2-weighted, short tau inversion recovery (STIR) and precontrast and postcontrast T1-weighted images were acquired. A well-defined...



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Infant born with Robert's syndrome without prenatal care in a developing nation

Maternal and child well-being during pregnancy can be attributed to receiving optimal prenatal care. However, in developing nations, there are many barriers to receiving this. We present a primigravid female aged 29 years with severe abdominal pain. She was in active labour at 40 weeks and completely unaware of her pregnancy; hence, she did not receive any prenatal care. The baby was born with significant birth deformities that were consistent with Robert's syndrome. Although early detection could not preclude the development of this disorder, proper care would have facilitated in receiving genetic counselling and proper understanding of the prognosis. In this case, we discuss the various barriers to receiving prenatal care and measures taken for improvement in developing nations.



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Persistent urinary incontinence after a robot-assisted artificial urinary sphincter procedure: lessons learnt from two cases

This case report describes 2 cases of persistent urinary incontinence in the beginning of the learning curve of robot-assisted bladder neck implantation of an artificial urinary sphincter (RA-AUS) in men at risk for erosion due to neurological lesions. Among a series of 4 RA-AUS, 2 patients still experienced urinary incontinence after surgery. A complete urological workup was strictly normal and did not show any device malfunction. However, during an AUS revision in these two patients, exploration revealed that the cuff was not tight enough. This issue was resolved by placing smaller cuffs. After re-do surgery, one of the two patients no longer had urinary incontinence, while the second patient was lost to follow-up. Insufficient tightness of the cuff could be explained by an inability of the surgeon to feel the force while pulling the cuff around the urethra due to the absence of haptic sensation in robotic surgery.



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Coronary artery bypass grafting with internal thoracic arteries may cause bilateral brachiocephalic vein occlusion, complicating pacemaker implantation

The number of patients with arrhythmia and ischaemic heart diseases is increasing. Patients with pacemaker implantation sometimes have brachiocephalic vein occlusion, and several aetiologies have been reported. However, coronary artery bypass grafting using the internal thoracic arteries is not fully discussed in the literature. We present a case of failed percutaneous pacemaker implantation due to bilateral brachiocephalic vein occlusion 8 years after coronary artery bypass grafting using the bilateral internal thoracic arteries. There were rich collateral veins consisting of hemiazygos and azygos veins. We then performed surgical implantation instead. Contrast CT or venography for such patients might be considered.



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Visual disturbance with systemic symptoms: old lessons revisited

We describe a retired physician who presented with visual disturbance and systemic symptoms. The presence of general malaise, headache and scalp tenderness, with raised inflammatory markers, suggested that giant cell arteritis (GCA) was the likely diagnosis. Rapid response to initial steroid therapy and histological evidence of inflammation in the temporal artery supported this diagnosis. The character of these visual symptoms was, however, atypical for GCA. The patient, who had heart valve disease, subsequently deteriorated and developed further symptoms warranting investigation of bacterial endocarditis. Retinal emboli are a recognised complication of endocarditis, which could account for these visual symptoms. Moreover, interpretation of the temporal artery biopsy is limited in the context of existing steroid therapy. Our patient was consequently diagnosed with bacterial endocarditis. This case reminds us to consider the wider differential diagnoses for headache, visual disturbance and systemic symptoms, where echocardiogram and blood cultures may be crucial to reach the diagnosis.



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Thiamine refractory Wernickes encephalopathy reversed with magnesium therapy

Description

A 34-year-old man was presented to our emergency department in alcohol withdrawal.

Despite initial treatment with high-dose intravenous thiamine therapy he went on to develop nystagmus (video 1), ataxia, pass pointing, intention tremor and worsening confusion. He was diagnosed with Wernickes encephalopathy, an acute neuropsychiatric syndrome resulting from thiamine deficiency.1

Video 1

Our patient demonstrates bilateral vertically upbeat nystagmus.

His serum magnesium levels were found to be low at 0.41 mmol/L (normal range 0.66–1.02 mmol/L). He was started on high-dose intravenous magnesium in addition to thiamine replacement and his neurological symptoms resolved once his serum magnesium levels had normalised (video 2).

Video 2

Our patient's nystagmus has improved, although a few beats remain at extreme lateral gaze.

He was discharged home and on review in clinic 4 weeks later, he had made a complete recovery.

Magnesium is an...



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Where did the clot go? An unusual complication of mechanical thrombectomy caused by malignancy related subclavian steal phenomenon in a patient with acute basilar artery occlusion

Subclavian steal is a relatively common vascular phenomenon usually caused by atherosclerotic disease. While symptoms are rare, arm claudication of the ipsilateral limb is most common, with paroxysmal symptoms of vertebrobasilar insufficiency (often exercise induced) being relatively uncommon. Here we present a case of brachial artery embolism during mechanical thrombectomy for basilar artery thrombosis, secondary to subclavian steal phenomenon. This atypical and potentially irreversible complication should be considered in patients with acute ischemic stroke undergoing neurointerventional management when subclavian steal is discovered angiographically.



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Severe Hyponatremia due to Levofloxacin Treatment for Pseudomonas aeruginosa Community-Acquired Pneumonia in a Patient with Oropharyngeal Cancer

Hyponatremia (serum Na levels of

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Pasteurella multocida Bacteremia in an Immunocompromised Patient

We present the case of a 61-year-old Caucasian gentleman who presented with a one-day history of fever, chills, and altered mental status. His symptoms were initially thought to be secondary to cellulitis. Blood cultures grew Pasteurella multocida, a rare pathogen to cause bacteremia. Our patient was treated with ciprofloxacin for two weeks and made a complete and uneventful recovery. Our patient's uncontrolled diabetes mellitus and chronic kidney disease put him at a higher risk for developing serious P. multocida infection. The patient's dog licking the wounds on his legs was considered as the possible source of infection. As P. multicoda bacteremia is rare, but severe with a high mortality rate, it is imperative to have a high index of suspicion for this infection especially in the vulnerable immunocompromised population.

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Role of parathyroid hormone in regeneration of irradiated bone in a murine model of mandibular distraction osteogenesis

Abstract

Background

The purpose of this study was to measure the histologic and histomorphometric effects of parathyroid hormone (PTH) treatment on irradiated bone undergoing distraction osteogenesis (DO).

Methods

Thirty-four rats were divided into 3 groups. The control group underwent DO and the radiation control group underwent radiotherapy (RT) before DO. The PTH group underwent RT and received PTH during DO. Quantitative histology and histomorphometry were performed.

Results

RT resulted in a depletion of osteocytes and increase in empty lacunae. Treatment with PTH resulted in an increase in osteocyte counts and decrease in empty lacunae (p < .05), restoring osteocytes to levels seen in nonradiated bone (p = .121). RT decreased bone volume to tissue volume (BV-TV) ratio and increased osteoid volume to tissue volume (OV-TV) ratio, signifying increased immature bone formation. PTH treatment restored OV-TV ratio to that observed in nonradiated bone.

Conclusion

PTH treatment of irradiated bone enhanced bone regeneration and restored osteocyte counts and OV-TV ratio to levels comparable to nonradiated bone. © 2016 Wiley Periodicals, Inc. Head Neck, 2016



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Ethik in der Onkologie − Indikation und Respekt vor der Autonomie



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