Head and Neck Medicine by Alexandros G.Sfakianakis: 03/07/16

Δευτέρα 7 Μαρτίου 2016

OtoRhinoLaryngology & Medicine,New Articles,March 8th,2016

Changes in macrophage function modulated by the lipid environment

alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 45 δευτερόλεπτα

Macrophages (Ms) play a critical role in the defense against pathogens, orchestrating the inflammatory response during injury and maintaining tissue homeostasis. During these processes, macrophages encounter a variety of environmental conditions that are likely to change their gene expression pattern, which modulates their function. In this study, we found that murine Ms displayed two different […]

Quality of life in patients with metastatic breast cancer treated with metronomic chemotherapy

Future Oncology Ahead of Print. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1p3XglC via IFTTT

Nodal metastases in thyroid cancer: prognostic implications and management

Future Oncology Ahead of Print. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1pclF9y via IFTTT

A PDGF-E2F-USP1-ID2 axis is required for proneural glioma

Glioblastoma (GBM) is the most aggressive primary brain tumor and responds poorly to currently available therapies. Transcriptomic characterization of GBM has identified distinct molecular subtypes of GBM. Gain-of-function alterations leading to enhanced platelet-derived growth factor (PDGF) signaling are commonly observed in the proneural subtype of GBM and can drive gliomagenesis. However, little is known about […]

C GAMP, Where Is Thy STING?

Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are required for the function of STING (TMEM173), an ER-resident transmembrane protein critical for cytoplasmic DNA sensing, IFN production, and cancer control. Here we show that the IRE-1/XBP-1 pathway functions downstream of STING and that STING agonists selectively trigger mitochondria-mediated apoptosis in normal and malignant B […]

Small cell mesothelioma: A rare entity and diagnostic pitfall mimicking small cell lung carcinoma on fine-needle aspiration

Quality of life in patients with metastatic breast cancer treated with metronomic chemotherapy

Future Oncology Ahead of Print. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1p3XglC via IFTTT

Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, successfully treated by radical cystectomy with adjuvant chemotherapy: a case report

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 1 λεπτό

[image: s13256-016-0806-x-1.gif] Background: Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, is a rare histological type of bladder cancer similar to plasma cells and is an aggressive variant of urothelial carcinoma associated with a poor prognosis.Case presentationA 41-year-old Asian man was referred to our hospital due to macroscopic hematuria. Cystoscopy detected a non-papillary tumor, and a transurethral resection of the bladder tumor revealed pT1N0M0 bladder cancer. A pathological examination showed high-grade invasive urothelial carcinoma and a component of...περισσότερα »

Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 1 λεπτό

[image: s13256-016-0833-7-5.gif] Background: Malignant transformation of giant cell tumors of bones, that is, secondary malignant giant cell tumor of bone, is rare. The most common symptoms are local pain and swelling. There are no prior reports of giant cell tumor of bone with fever of unknown origin at the onset. Here we present a case of a secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin.Case presentationA 75-year-old Asian man presented with a 3-week history of co...περισσότερα »

Novel molecular processes controlling key genes in prostate cancer uncovered

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 3 δευτερόλεπτα

Researchers at Karolinska Institutet and the University of Oulu in Finland have elucidated gene regulatory mechanisms that can explain how known genetic variants influence prostate cancer risk. The findings, published in the journal Nature Genetics, reveal widespread deregulation of androgen receptor function, a key player in prostate cancer. The vast majority of the three billion base-pairs in the human genome are identical across individuals. Nevertheless, genome sequence variation that does occur in the population has a profound effect on an individual's predisposition for deve... περισσότερα »

Increased anticipatory contingent negative variation in posttraumatic stress disorder

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 3 δευτερόλεπτα

[image: alertIcon.gif] Publication date: Available online 7 March 2016 *Source:*Biological Psychology Author(s): Hongxia Duan, Li Wang, Guillén Fernández, Kan Zhang, Jianhui Wu Altered anticipation processes are implicated across various clinical samples, but few studies focused on the posttraumatic stress disorder (PTSD). We measured contingent negative variation (CNV) in a choice reaction paradigm among 58 survivors of the Wenchuan earthquake, including 28 individuals who were diagnosed with PTSD and 30 without PTSD. Compared to the non-PTSD group, the PTSD group had significantly ...περισσότερα »

Contamination of urinary cultures in initial-stream versus later-stream urine in children undergoing bladder catheterization for the diagnosis of urinary tract infection.

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα

Background: Urine cultures obtained by bladder catheterization can be contaminated by bacteria colonizing the distal urethra. Data are inconclusive regarding the potential advantage of discarding the first few urine drops obtained by bladder catheterization and testing only the sample of late-stream urine, thus reducing the likelihood of urine culture contamination. Aim: The aim of this study was to evaluate whether the incidence of contaminated urine cultures obtained by bladder catheterization can be reduced by splitting urine samples into 'initial' and 'late' samples and using on... περισσότερα »

Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, successfully treated by radical cystectomy with adjuvant chemotherapy: a case report

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 15 δευτερόλεπτα

Background: Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, is a rare histological type of bladder cancer similar to plasma cells and is an aggressive variant of urothelial carcinoma associated with a poor prognosis.Case presentationA 41-year-old Asian man was referred to our hospital due to macroscopic hematuria. Cystoscopy detected a non-papillary tumor, and a transurethral resection of the […]

Steatocystoma simplex in penile foreskin: a case report

Background: Steatocystoma simplex is an uncommon skin lesion with a histological pattern that is identical to that of steatocystoma multiplex. We are reporting this case of steatocystoma simplex for its uncommon location in the penile foreskin, and its occurrence in a Wapishana man.Case presentationA 56-year-old man of Wapishana ethnicity presented with complaints of referred penile […]

Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report

Background: Malignant transformation of giant cell tumors of bones, that is, secondary malignant giant cell tumor of bone, is rare. The most common symptoms are local pain and swelling. There are no prior reports of giant cell tumor of bone with fever of unknown origin at the onset. Here we present a case of a […]

Hoogsteen-position pyrimidines promote the stability and function of the MALAT1 RNA triple helix REPORT

Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, successfully treated by radical cystectomy with adjuvant chemotherapy: a case report

Reproductive alterations in hyperinsulinemic but normoandrogenic MSG-obese female rats

Obesity and metabolic syndrome are a common cause of reproductive and fertility disorders in women. In special, polycystic ovary syndrome, which is clinically characterized by hyperandrogenism, oligo/anovulation, and polycystic ovarian morphology, has been increasingly associated with metabolic disorders. However, given the broad interplay between metabolic and reproductive functions, this remains a field of intense research. […]

The deadenylase components Not2p, Not3p, and Not5p promote mRNA decapping REPORT

Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report

Selectively enhanced photocurrent generation in twisted bilayer graphene with van Hove singularity

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα

Article Graphene has the high carrier mobility and short photoresponse time required for efficient photodetection, but broad and weak optical absorption are severe drawbacks. Here, the authors show that twisted bilayer graphene with van Hove singularities exhibits a strong light-matter interaction and selectively enhanced photocurrent generation. Nature Communications doi: 10.1038/ncomms10699 Authors: Jianbo Yin, Huan Wang,… Continue reading Selectively enhanced photocurrent generation in twisted bilayer graphene with van Hove singularity

Data publication with the structural biology data grid supports live analysis

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα

Article The validation and analysis of X-ray crystallographic data is essential for reproducibility and the development of crystallographic methods. Here, the authors describe a repository for crystallographic datasets and demonstrate some of the ways it could serve the crystallographic community. Nature Communications doi: 10.1038/ncomms10882 Authors: Peter A. Meyer, Stephanie Socias, Jason Key, Elizabeth Ransey, Emily… Continue reading Data publication with the structural biology data grid supports live analysis

CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα

Article CSF-contacting neurons are known to project to locomotor CPGs although their relevance to active locomotion is unclear. Here, the authors show that these cells constitute a mechanosensory organ relying on PKD2L1 channels to detect spinal cord curvature and modulate locomotor frequency in freely moving animals. Nature Communications doi: 10.1038/ncomms10866 Authors: Urs Lucas Böhm, Andrew… Continue reading CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits

Rule learning enhances structural plasticity of long-range axons in frontal cortex

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα

Article The orbitofrontal cortex is associated with foraging behaviour yet the structural changes underlying such rule-based learning remain unclear. Here, the authors imaged OFC axons throughout a digging-based odour discrimination task and found correlations between the rate of bouton turnover and the behavioural strategies of individual mice. Nature Communications doi: 10.1038/ncomms10785 Authors: Carolyn M. Johnson,… Continue reading Rule learning enhances structural plasticity of long-range axons in frontal cortex

Designing high-performance layered thermoelectric materials through orbital engineering

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα

Article Thermoelectric materials with enhanced performances need to be identified. Here, the authors use the crystal field splitting energy of orbitals as a descriptor to design thermoelectric materials by solid solution maps and strain engineering in layered CaAl 2 Si 2 -type Zintl compounds. Nature Communications doi: 10.1038/ncomms10892 Authors: Jiawei Zhang, Lirong Song, Georg K.… Continue reading Designing high-performance layered thermoelectric materials through orbital engineering

Cohort profile: the Spanish WORKing life Social Security (WORKss) cohort study

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα

Purpose The global economy is changing the labour market and social protection systems in Europe. The effect of both changes on health needs to be monitored in view of an ageing population and the resulting increase in prevalence of chronic health conditions. The Spanish WORKing life Social Security (WORKss) cohort study provides unique longitudinal data… Continue reading Cohort profile: the Spanish WORKing life Social Security (WORKss) cohort study

Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα

Article Microglia play key roles during early neurodevelopment. Here the authors show that microglia are important mediators of ocular dominance plasticity (ODP). Microglia respond to monocular deprivation during the visual critical period, and disrupting microglial P2Y12 purinergic receptor abrogates ODP. Nature Communications doi: 10.1038/ncomms10905 Authors: G. O. Sipe, R. L. Lowery,, M-È Tremblay, E. A.… Continue reading Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

Nail dystrophy as the initial sign of multiple myeloma-associated systemic amyloidosis

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα

from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1Yq4Mnm via IFTTT

Reconstruction for Defects at the Base of the Philtrum Affecting the Upper Lip Vermilion.

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 28 δευτερόλεπτα

No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1QHVH4a via IFTTT

Commentary on Clinical and Histopathological Assessment of Facial Melasma After Low-fluence Q-switched Neodymium-doped Yttrium Aluminium Garnet Laser.

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 28 δευτερόλεπτα

No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1SwaNyn via IFTTT

Retrospective Review of Risk Factors Predictive of Complications in Patients After Below the Knee Mohs Micrographic Surgery.

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 28 δευτερόλεπτα

No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1QHVIVG via IFTTT

Contamination of urinary cultures in initial-stream versus later-stream urine in children undergoing bladder catheterization for the diagnosis of urinary tract infection.

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα

Paediatric workload of an adult retrieval service in Scotland.

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα

The Emergency Medical Retrieval Service (EMRS) provides adults with life-threatening conditions in remote areas with timely interventions and rapid access to definitive medical care, including a primary response service. Paediatric patients are managed under a separate network. Despite this, there has been an increase in paediatric retrievals by EMRS. We aim to inform future service development and ascertain how EMRS can serve the needs of this cohort. This is a retrospective, observational study. Raw data were retrieved from the database of paediatric patients retrieved by EMRS for... περισσότερα »

IL-10 and HPV-/EBV-associated cancers

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα

IL-10 and HPV-/EBV-associated cancers: Kai Qu,1,* Qing Pang,1,* Ting Lin,1 Li Zhang,2 Mingliang Gu,3 Wenquan Niu,4 Chang Liu,1,* Ming Zhang5 1Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi Province, People’s Republic of China; 2Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, People’s Republic of China; 3Chinese Academy of Sciences Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy ...περισσότερα »

Advanced/Metastatic Soft Tissue Sarcoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα

Evolution of Randomized Trials in Advanced/Metastatic Soft Tissue Sarcoma: Endpoint Selection, Surrogacy, and Quality of Reporting [ORIGINAL REPORTS]: Purpose Randomized controlled trials (RCTs) in soft tissue sarcoma (STS) have used varying endpoints. The surrogacy of intermediate endpoints, such as progression-free survival (PFS), response rate (RR), and 3-month and 6-month PFS (3moPFS and 6moPFS) with overall survival (OS), remains unknown. The quality of efficacy and toxicity reporting in these studies is also uncertain. Methods A systematic review of systemic therapy RCTs in ...περισσότερα »

Advanced Melanoma Treated With Pembrolizumab

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα

Evaluation of Immune-Related Response Criteria and RECIST v1.1 in Patients With Advanced Melanoma Treated With Pembrolizumab [Immunotherapy]: Purpose We evaluated atypical response patterns and the relationship between overall survival and best overall response measured per immune-related response criteria (irRC) and Response Evaluation Criteria in Solid Tumors, version 1.1 (RECIST v1.1) in patients with advanced melanoma treated with pembrolizumab in the phase Ib KEYNOTE-001 study (clinical trial information: NCT01295827). Patients and Methods Patients received pembrolizumab 2 or ... περισσότερα »

Cardiovascular Disease Risk Profiles in Survivors of Adolescent and Young Adult (AYA) Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα

Cardiovascular Disease Risk Profiles in Survivors of Adolescent and Young Adult (AYA) Cancer: The Kaiser Permanente AYA Cancer Survivors Study [Epidemiology]: Purpose To describe the epidemiology and risk factors for cardiovascular disease (CVD) in survivors of adolescent and young adult (AYA) cancer. Methods We identified a retrospective cohort of 2-year survivors of AYA cancer who were diagnosed between the ages of 15 to 39 years (1998 to 2009) at Kaiser Permanente Southern California. A comparison group without cancer was selected and matched 10:1 to cancer survivors on the basi...περισσότερα »

Nodal metastases in thyroid cancer: prognostic implications and management

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα

Nodal metastases in thyroid cancer: prognostic implications and management: Future Oncology Ahead of Print. Laura Y Wang1 & Ian Ganly*,1 *Author for correspondence: ganlyi@mskcc.org The significance of cervical lymph node metastases in differentiated thyroid cancer has been controversial and continues to evolve. Current staging systems consider nodal metastases to confer a poorer prognosis, particularly in older patients. Increasingly, the literature suggests that characteristics of the metastatic lymph nodes such as size and number are also prognostic. There is a growing tre...περισσότερα »

Multimodal cancer care in poor prognosis cancers

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα

Multimodal cancer care in poor prognosis cancers: Resection drives long-term outcomes: Background and Objectives Hospitals with high complex oncologic surgical volume have improved short-term outcomes. However, for long-term outcomes, the influence of other therapies must be considered. We compared effects of resection with other therapies on long-term outcomes across U.S. hospitals. Methods We examined claims in the Surveillance, Epidemiology, and End Results (SEER)-Medicare dataset for patients with esophageal (EC) and pancreatic (PC) cancers between 2005–2009, with follow-up thro... περισσότερα »

Effects of Prenatal Dexamethasone on the Pituitary Gland and Gonadotropic Cells in Female Offspring

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα

Effects of Prenatal Dexamethasone on the Rat Pituitary Gland and Gonadotropic Cells in Female Offspring: Glucocorticoids have a strong influence on growth and maturation of fetal organ systems, but overexposure to exogenous glucocorticoids may retard fetal growth and alter developmental processes in sensitive tissues. The aim of this study was to specifically determine whether prenatal exposure to dexamethasone (Dx) altered normal development and function of pituitary gonadotropic cells in neonatal, infant and peripubertal female offspring. On day 16 of pregnancy, rat dams received ...περισσότερα »

Myosin Heavy Chain Expression Can Vary over the Length of Jaw and Leg Muscles

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα

Myosin Heavy Chain Expression Can Vary over the Length of Jaw and Leg Muscles: Muscle fiber type classification can be determined by its myosin heavy chain (MyHC) composition based on a few consecutive sections. It is generally assumed that the MyHC expression of a muscle fiber is the same over its length since neural stimulation and systemic influences are supposed to be the same over its length. We analyzed this in detail in three muscle types: the temporalis (closer) and digastricus (opener; both first brachial arch), and the medial gastrocnemius (somite). Sections of the muscles...περισσότερα »

Do epinephrine auto-injectors have an unsuitable needle length in children and adolescents at risk for anaphylaxis from food allergy?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα

Do epinephrine auto-injectors have an unsuitable needle length in children and adolescents at risk for anaphylaxis from food allergy?: Food allergy is the most common cause of anaphylaxis in children. Intramuscular delivery of epinephrine auto-injectors (EAI) is the standard of care for the treatment of anaphylaxis. We examined if children an... Sten Dreborg, Xia Wen, Laura Kim, Gina Tsai, Immaculate Nevis, Ryan Potts, Jack Chiu, Arunmozhi Dominic and Harold KimEmail author Allergy, Asthma & Clinical Immunology201612:11 DOI: 10.1186/s13223-016-0110-8© Dreborg et al. 2016 Rece...περισσότερα »

Changes in macrophage function modulated by the lipid environment

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα

Changes in macrophage function modulated by the lipid environment: Macrophages (Ms) play a critical role in the defense against pathogens, orchestrating the inflammatory response during injury and maintaining tissue homeostasis. During these processes, macrophages encounter a variety of environmental conditions that are likely to change their gene expression pattern, which modulates their function. In this study, we found that murine Ms displayed two different subpopulations characterized by differences in morphologies, expression of surface markers and phagocytic capacity under no...περισσότερα »

Diabetic osteomyelitis : Erythrocyte sedimentation rate and C-reactive protein to monitor treatment outcomes

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα

Erythrocyte sedimentation rate and C-reactive protein to monitor treatment outcomes in diabetic foot osteomyelitis: Abstract This study sought to evaluate the effectiveness of the inflammatory markers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), in monitoring treatment of osteomyelitis in the diabetic foot. We screened 150 charts of patients admitted to our hospital with diabetic foot osteomyelitis (DFO), confirmed by positive results of bone culture and/or histopathology. We included patients who had an initial ESR/CRP within 72 hours of admission and two re... περισσότερα »

Dendritic cells generated from peripheral blood monocytes (Mo-DCs) and stimulated with laryngeal cancer cell lysates are not good enough in stimulating anti-tumor immunity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα

Dendritic cells generated from peripheral blood monocytes (Mo-DCs) and stimulated with laryngeal cancer cell lysates are not good enough in stimulating anti-tumor immunity: The use of immunotherapy as an adjuvant traditional treatment could prevent metastasis and give a chance for longer survival of cancer patients. It is known that the dendritic cells are the most effective antigen presenting cells (APC) and are the only APCs which activate innate T cells, therefore, they may involve additional forces to attack the cancerous cells [3]. The purpose of the use of immunotherapy is to ... περισσότερα »

Une cellulite nécrosante cervicale révélant un syndrome de Lemierre

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα

Une cellulite nécrosante cervicale révélant un syndrome de Lemierre via Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Publication date: Available online 7 March 2016 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): C. Assouan, A. Salami, E. Anzouan-Kacou, N. Nguessan, E. Konan IntroductionLe syndrome de Lemierre est caractérisé par une thrombophlébite septique de la veine jugulaire interne (VJI) consécutive le plus souvent à une infection oropharyngée.Cas cliniqueNous rapportons un cas de syndrome de Lemierre surv...περισσότερα »

Spatial plasticity of the auditory cortex in single-sided deafness

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 36 δευτερόλεπτα

[image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis To evaluate spatial plasticity of the auditory cortex in single-sided deafness (SSD). Study Design Cross-sectional study comparing a cohort with adult-onset, idiopathic SSD to a cohort with normal hearing. Methods Demographic, audiometric, magnetoencephalographic imaging, and magnetic resonance imaging data were collected for 13 SSD adult subjects and 13 normal-hearing controls. Locations of peak activation corresponding to the M100 response in auditory cortices ipsilateral and contralateral to tonal stimu...περισσότερα »

Utilisation de la hyaluronidase pour la correction des injections d’acide hyaluronique en médecine esthétique

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα

Utilisation de la hyaluronidase pour la correction des injections d’acide hyaluronique en médecine esthétique via Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Publication date: Available online 7 March 2016 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): C. Lacoste, B. Hersant, R. Bosc, W. Noel, J.P. Meningaud L’acide hyaluronique (AH) est le produit de comblement le plus utilisé en médecine esthétique. Cependant une surcorrection peut survenir même aux mains de praticiens expérimentés. La hyaluronidase est une... περισσότερα »

Oral erosions and ulcers

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα

Atteinte plurifocale de syphilis secondaire : présentation d’un cas via Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Publication date: Available online 7 March 2016 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): F. Campana, J. Carvelli, J.C. Fricain, B. Vergier, F. Boralevi, G. Kaplanski IntroductionLa syphilis est une infection sexuellement transmissible (IST) liée au Treponema pallidum. La syphilis secondaire correspond à la diffusion systémique hématogène du tréponème.ObservationNous rapportons un cas de sy...περισσότερα »

Spatial plasticity of the auditory cortex in single-sided deafness

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα

Objectives/Hypothesis To evaluate spatial plasticity of the auditory cortex in single-sided deafness (SSD). Study Design Cross-sectional study comparing a cohort with adult-onset, idiopathic SSD to a cohort with normal hearing. Methods Demographic, audiometric, magnetoencephalographic imaging, and magnetic resonance imaging data were collected for 13 SSD adult subjects and 13 normal-hearing controls. Locations of peak activation […]

Reproductive alterations in hyperinsulinemic but normoandrogenic MSG-obese female rats

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα

Invasive urothelial carcinoma, lymphoma-like/plasmacytoid variant, successfully treated by radical cystectomy with adjuvant chemotherapy: a case report

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα

Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα

Steatocystoma simplex in penile foreskin: a case report

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα

Use of a knowledge-attitude-behaviour education programme for Chinese adults undergoing maintenance haemodialysis: Randomized controlled trial

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα

Objective To investigate the effects of a knowledge-attitude-behaviour health education model on acquisition of disease-related knowledge and self-management behaviour by patients undergoing maintenance haemodialysis. Methods Patients recently prescribed MHD were randomly assigned to a control group or an intervention group. Control group patients were treated with usual care and general education models. A specialist knowledge-attitude-behaviour […]

Inequity Leads to Distress and a Reduction in Satisfaction: Evidence From a Priming Experiment

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα

Considerable research has shown that perceptions of inequity in relationships are associated with distress and relationship dissatisfaction, thus providing support for equity theory’s predictions. The evidence, however, is based primarily on correlational data, making it difficult to determine causality. The reverse causal direction could also explain the correlational findings—dissatisfaction could lead to perceptions of inequity. […]

Patient-Reported Outcomes After Choice for Contralateral Prophylactic Mastectomy Surgical Oncology

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα

Purpose The rate of contralateral prophylactic mastectomies (CPMs) continues to rise, although there is little evidence to support improvement in quality of life (QOL) with CPM. We sought to ascertain whether patient-reported outcomes and, more specifically, QOL differed according to receipt of CPM. Methods Volunteers recruited from the Army of Women with a history of […]

Impact of Subsequent Therapies on Outcome of the FIRE-3/AIO KRK0306 Trial CORRESPONDENCE

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OYaEwW via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel:00302841026182 & 00306932607174

Is Estradiol Monitoring Necessary in Women Receiving Ovarian Suppression for Breast Cancer? ONCOLOGY GRAND ROUNDS

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers […]

Harlequin's syndrome is a neurological disorder due to a dysfunction of the sympathetic innervation of the face

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα

Syndrome d’Arlequin chez un patient mélanoderme via Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Publication date: Available online 7 March 2016 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): C. Assouan, A. Salami, A. Kadre, N.D. N’guessan, E. Anzouan-Kacou, E. Konan IntroductionLe syndrome d’Arlequin est un trouble neurologique de topographie faciale, lié à une dysfonction de l’innervation sympathique de la face. Il est rarement décrit dans la littérature. Les auteurs décrivent un cas observé chez un sujet mé... περισσότερα »

Localisation palatine d’une maladie de Kimura

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα

Localisation palatine d’une maladie de Kimura via Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Publication date: Available online 7 March 2016 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): L. Benslama, D. Labrousse, F. Gruffaz, P. Goudot IntroductionLa maladie de Kimura est une affection inflammatoire auto-immune endémique dans les pays du Moyen-Orient et d’Asie, rare en Europe. Habituellement, l’atteinte cervico-faciale se manifeste par des lésions sous-cutanées nodulaires associées à des adénopathies cervica...περισσότερα »

Haemostatic property of cyanoacrylate in pedicled flaps

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα

Haemostatic property of cyanoacrylate in pedicled flaps via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 7 March 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): John Michael Ranson, Kavit Amin, Eyal M.M. Schechter, Damir Kosutic We present a technique that can, in principle, be applied to any pedicled flap that is routinely used for reconstructions of the forehead. In our experience, cyanoacrylate glue applied to the pedicle before the flap is inserted decreases postoperative bleeding and wound exudate.

An Injectable for Cartilage Regeneration

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα

Fibrin Hydrogels Functionalized with Particulated Cartilage Extracellular Matrix and Incorporating Freshly Isolated Stromal Cells as an Injectable for Cartilage Regeneration via Acta Biomaterialia Publication date: Available online 4 March 2016 *Source:*Acta Biomaterialia Author(s): H.V. Almeida, R. Eswaramoorthy, G.M. Cunniffe, C.T. Buckley, F.J. O’Brien, D.J. Kelly Freshly isolated stromal cells can potentially be used as an alternative to in vitro expanded cells in regenerative medicine. Their use requires the development of bioactive hydrogels or scaffolds which provide an environ... περισσότερα »

Anti-biofouling interface on hydroxyapatite surface by coating zwitterionic MPC polymer containing calcium-binding moieties to prevent oral bacterial adhesion

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα

Development of via Acta Biomaterialia Publication date: Available online 4 March 2016 *Source:*Acta Biomaterialia Author(s): Sunah Kang, Myoungjin Lee, Minji Kang, Minwoo Noh, Joohee Jeon, Yan Lee, Ji-Hun Seo The purpose of the present study is to synthesize a 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer capable of being immobilized on the tooth surface to prevent oral bacterial adhesion. The strategy is to develop an MPC-based polymer with Ca2+-binding moieties, i.e., phosphomonoester groups, for stronger binding with hydroxyapatite (HA) of the tooth surface. To this end, ... περισσότερα »

Copper-containing bioactive glass/eggshell membrane nanocomposites for improving angiogenesis, antibacterial activity and wound healing

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα

Preparation of via Acta Biomaterialia Publication date: Available online 7 March 2016 *Source:*Acta Biomaterialia Author(s): Jinyan Li, Dong Zhai, Fang Lv, Qingqing Yu, Hongshi Ma, Jinbo Yin, Zhengfang Yi, Mingyao Liu, Jiang Chang, Chengtie Wu Effectively stimulating angiogenesis and avoiding wound infection are great challenges in wound care management. Designing new healing dressings with requisite angiogenic capacity and antibacterial performance is of particular significance. In order to achieve this aim, we prepared a copper (Cu)-containing bioactive glass nanocoating (40-50 nm) ... περισσότερα »

Sleep-disordered breathing in orthodontic practice

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

Sleep-disordered breathing in orthodontic practice: Abstract ObjectivesThe purpose of this work was to evaluate the prevalence of snoring and its correlation with cranial and upper airway morphology in young individuals with orthodontic treatment need. Patients and methodsParents of 379 children were consecutively interviewed, using eight questions from a more comprehensive questionnaire about sleep behavior. A total of 100 patients (54 girls, 46 boys, average age 11.3 years) met the inclusion criteria. Based on the parents’ interviews, the sample was divided into snorers (*n* ... περισσότερα »

Aided Electrophysiology Using Direct Audio Input: Effects of Amplification and Absolute Signal Level

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

Aided Electrophysiology Using Direct Audio Input: Effects of Amplification and Absolute Signal Level: Purpose This study investigated (a) the effect of amplification on cortical auditory evoked potentials (CAEPs) at different signal levels when signal-to-noise ratios (SNRs) were equated between unaided and aided conditions, and (b) the effect of absolute signal level on aided CAEPs when SNR was held constant. Method CAEPs were recorded from 13 young adults with normal hearing. A 1000-Hz pure tone was presented in unaided and aided conditions with a linear analog hearing aid. Dire... περισσότερα »

Craniofacial and Dental Defects in the Col1a1Jrt/+ Mouse Model of Osteogenesis Imperfecta

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 45 δευτερόλεπτα

Certain mutations in the *COL1A1* and *COL1A2* genes produce clinical symptoms of both osteogenesis imperfecta (OI) and Ehlers-Danlos syndrome (EDS) that include abnormal craniofacial growth, dental malocclusion, and dentinogenesis imperfecta. A mouse model (*Col1a1Jrt/+*) was recently developed that had a skeletal phenotype and other features consistent with moderate-to-severe OI and also with EDS. The craniofacial phenotype of 4- and 20-wk-old *Col1a1Jrt/+* mice and wild-type littermates was assessed by micro–computed tomography (µCT) and morphometry. Teeth and the periodontal l... περισσότερα »

Online Tone Generator

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα

Online Tone Generator: Tinnitus is a medical condition in which a person hears a sound from within their ears, but there is no external sound present in the environment. This auto-generated sound may occur only at certain times, such as when the person is under stress, or it may be an all day and all night long experience. If you have tinnitus, there are treatment options that may help to lessen your symptoms. An online tone generator for tinnitus is one convenient way to take control of tinnitus and regain your sense of hearing. Types of Tinnitus Tones Tinnitus is not a disease i... περισσότερα »

Functional imaging in migraine.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα

Functional imaging in migraine.: Afridi, S.K.; (2005) Functional imaging in migraine. Doctoral thesis, University of London. Green open access Afridi, S.K.; (2005) Functional imaging in migraine. Doctoral thesis, University of London. [image: Green open access] [image: [img]] Text U592564.pdf Download (7MB) Abstract Migraine is a common disabling condition likely to be associated with dysfunction of brain pathways involved in pain and other sensory modalities. Functional brain imaging in acute migraine has proved challenging due to the logistic problems associated with ... περισσότερα »

Characterization of Candida species of the mouth

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα

Characterization of Candida species of the mouth in healthy patients and following bone marrow transplantations.: Al-Karaawi, Z.; (2005) Characterization of Candida species of the mouth in healthy patients and following bone marrow transplantations. Doctoral thesis, University of London. Green open access Al-Karaawi, Z.; (2005) Characterization of Candida species of the mouth in healthy patients and following bone marrow transplantations. Doctoral thesis, University of London. [image: Green open access] [image: [img]] Text U592576 Redacted.PDF Download (12MB) Abstract ... περισσότερα »

The Mechanics of Brow-suspension Ptosis Repair

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα

*The Mechanics of Brow-suspension Ptosis Repair: A Comparative Study of Fox Pentagon and Crawford Triangle Techniques.: Kwon, KA; Shipley, RJ; Edirisinghe, M; Best, SM; Cameron, RE; Poitelea, C; Rose, GE; Kwon, KA; Shipley, RJ; Edirisinghe, M; Best, SM; Cameron, RE; Poitelea, C; Rose, GE; Ezra, DG; - view fewer (2016) The Mechanics of Brow-suspension Ptosis Repair: A Comparative Study of Fox Pentagon and Crawford Triangle Techniques. Ophthal Plast Reconstr Surg 10.1097/IOP.0000000000000621 . * *Kwon, KA; Shipley, RJ; Edirisinghe, M; Best, SM; Cameron, RE; Poitelea, C; Rose, GE;... περισσότερα »

Materials & Design

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα

Submicron lamellar porous structure formed by selective dissolution of Ti-Al alloy Publication date: 15 May 2016 *Source:*Materials & Design, Volume 98 Author(s): Dai-Xiu Wei, Yuichiro Koizumi, Yunping Li, Kenta Yamanak, Akihiko Chiba We created high-aspect-ratio sub-micron-sized lamellar porous structure by simple anodic selective dissolution of lamellar Ti-Al alloy in NaCl aqueous solution. The geometries of lamellar structures, which determined those of lamellar porous structure, were controlled by hot forging and subsequent ageing treatment before dissolution process. Altho... περισσότερα »

Fabrication of bespoke nasal septal scaffolds

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα

*Fabrication of bespoke nasal septal scaffolds: Hashimdeen, SH; Thorogate, R; Miodownik, M; Edirisinghe, MJ; (2016) Fabrication of bespoke nasal septal scaffolds. MATERIALS & DESIGN , 90 pp. 403-409. 10.1016/j.matdes.2015.10.120 . * Highlights *•* *Electrohydrodynamic (EHD) printing of polymeric nasal septal scaffolds was performed.* *•* *A special EHD desktop-printer with replication rapid prototyping technology was used.* *•* *Polymer concentration was varied to create three distinct scaffold architectures.* *•* *Nanomechanical mapping was used to assess scaffold deformation and... περισσότερα »

Robotics in otolaryngology and head and neck surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα

Robotics in otolaryngology and head and neck surgery: Recommendations for training and credentialing: A report of the 2015 AHNS education committee, AAO-HNS robotic task force and AAO-HNS sleep disorders committee: Abstract Training and credentialing for robotic surgery in otolaryngology - head and neck surgery is currently not standardized, but rather relies heavily on industry guidance. This manuscript represents a comprehensive review of this increasingly important topic and outlines clear recommendations to better standardize the practice. The recommendations provided can be use...περισσότερα »

Acute sinusitis complicated by subperiosteal abscess in children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα

Microbiology and choice of antimicrobial therapy for via International Journal of Pediatric Otorhinolaryngology Publication date: May 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 84 Author(s): Itzhak Brook ObjectivesReview past studies of the microbiology of subperiosteal abscesses (SPOA) complicating sinusitis in children and their implications of the antimicrobials administered to treat the infection.MethodsLiterature search was conducted of the Cochrane Library, EMBASE, TRIP, EMBASE, and MEDLINE databases from their inception.ResultsThe most common pa...περισσότερα »

Hearing loss in urban school children (grade 1 to 3)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα

Hearing loss in urban South African school children (grade 1 to 3) via International Journal of Pediatric Otorhinolaryngology Publication date: May 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 84 Author(s): Faheema Mahomed-Asmail, De Wet Swanepoel, Robert H. Eikelboom ObjectiveThis study aimed to describe the prevalence and characteristics of hearing loss in school-aged children in an urban South African population.MethodChildren from grade one to three from five schools in the Gauteng Province of South Africa formed a representative sample for this study...περισσότερα »

Cinnamaldehyde is an effective anti-inflammatory agent for treatment of allergic rhinitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα

in a rat model via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 7 March 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Deniz Hancı, Hüseyin Altun, Erdem Atalay Çetinkaya, Nuray Bayar Muluk, Betül Peker Cengiz, Cemal Cingi ObjectivesThe effect of cinnamaldehyde on the treatment of allergic rhinitis (AR) was investigated in rat model.MethodsTwenty-eight female Wistar albino rats were randomly divided into four groups: Group 1 (control) (C), Group 2 (AR with no treatment) (AR+NoTr), Group 3 (AR+Azelastine HCl) ...περισσότερα »

Age- and Gender-Related Mean Hearing Threshold in a Highly-Screened Population

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα

Age- and Gender-Related Mean Hearing Threshold in a Highly-Screened Population: The Korean National Health and Nutrition Examination Survey 2010–2012: by Yun Hwi Park, Seung-Ho Shin, Sung Wan Byun, Ju Yeon Kim Background In evaluating hearing disability in medicolegal work, the apportionment of age- and gender-related sensorineural hearing loss should be considered as a prior factor, especially for the elderly. However, in the literature written in the English language no studies have reported on the age- and gender-related mean hearing threshold for the South Korean population. ...περισσότερα »

Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα

Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers: [image: access_no.gif] Thyroid , Vol. 0, No. 0. Author information Patricia Aragon Han,1 Hyun-seok Kim,1 Soonweng Cho,1 Roghayeh Fazeli,1 Alireza Najafian,1 Hunain Khawaja,1 Melissa McAlexander,2 Benzon Dy,3 Meredith Sorensen,4 Anna Aronova,5 Thomas J. Sebo,6Thomas J. Giordano,7 Thomas J. Fahey III,5 Geoffrey B. Thompson,3 Paul G. Gauger,4 Helina Somervell,1 Justin A. Bishop,8 James R. Eshleman,8 Eric ...περισσότερα »

Patterns of lymphatic spread and the management of eyelid carcinomas

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα

Patterns of lymphatic spread and the management of eyelid carcinomas: Eyelid carcinomas are rare, and the management strategy of regional lymph node metastasis linked to eyelid carcinomas has not been standardized to date. The aim of the present study was to analyze the patterns of regional metastasis and to assess the optimal extent of surgical treatment for lymph node metastasis of eyelid carcinoma. AbstractObjective Eyelid carcinomas are rare, and the management strategy of regional lymph node metastasis linked to eyelid carcinomas has not been standardized to date. The aim of... περισσότερα »

External Validation of the Acoustic Voice Quality Index Version 03.01 With Extended Representativity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα

External Validation of the Acoustic Voice Quality Index Version 03.01 With Extended Representativity: Objectives: The Acoustic Voice Quality Index (AVQI) is an objective method to quantify the severity of overall voice quality in concatenated continuous speech and sustained phonation segments. Recently, AVQI was successfully modified to be more representative and ecologically valid because the internal consistency of AVQI was balanced out through equal proportion of the 2 speech types. The present investigation aims to explore its external validation in a large data set. Methods: ...περισσότερα »

Craniofacial and Dental Defects in the Osteogenesis Imperfecta

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα

Craniofacial and Dental Defects in the Col1a1Jrt/+ Mouse Model of Osteogenesis Imperfecta: Certain mutations in the *COL1A1* and *COL1A2* genes produce clinical symptoms of both osteogenesis imperfecta (OI) and Ehlers-Danlos syndrome (EDS) that include abnormal craniofacial growth, dental malocclusion, and dentinogenesis imperfecta. A mouse model (*Col1a1Jrt/+*) was recently developed that had a skeletal phenotype and other features consistent with moderate-to-severe OI and also with EDS. The craniofacial phenotype of 4- and 20-wk-old *Col1a1Jrt/+* mice and wild-type littermates wa... περισσότερα »