Increased expression of phosphorylated forms of heat-shock protein-27 and p38MAPK in macrophage-rich regions of fibro-fatty atherosclerotic lesions in the rabbit
Summary We aimed to assess the expression and distribution of Hsp27, pHsp27 (Ser82), p38MAPK and p-p38MAPK in fibro-fatty atherosclerotic lesions and the myocardium of hypercholesterolaemic rabbits. Male New Zealand white rabbits were fed a high-cholesterol diet for 18 weeks, maintaining serum cholesterol at approximately 20 mmol/l over this period. Aortic arch and myocardial tissues were analysed by Western blot, immunohistochemistry and double immunofluorescence. Plasma Hsp27 levels were measured by ELISA. There was a significant increase in the expression of monomeric and dimeri... περισσότερα »
Prenatal exposure to ethinylestradiol alters the morphologic patterns and increases the predisposition for prostatic lesions in male and female gerbils during ageing
Summary Ethinylestradiol (EE) is an endocrine disruptor (ED) which acts as an oestrogen agonist; this compound is known as an oral contraceptive. Male and female rodents exposed to EE during critical time points of development, such as in the prenatal period, show alterations in their reproductive tract during adulthood. Few studies have placed an emphasis on the effects of EE during ageing. Thus, this study had as it's objective the analysis of the morphological and immunohistochemical effects of exposure to EE in the prenatal period on ventral male prostate and female prostate o...περισσότερα »
Sleep Apnea Treatment- The Canadian Experience
Sleep Apnea Treatment- The Canadian Experience: So, you’re tired of feeling tired or hearing from your spouse about your snoring. You go to your family physician, which refers you to a Sleep Specialist. After the Sleep Study results are available you are told that you stop breathing in your sleep 30 times an hour, something that would concern most people. You are then told about lifestyle modifications that you may want to consider, and various therapeutic approaches. But the one they highly recommend, and that the government sponsored Health Plan covers is CPAP. Continuous Positiv... περισσότερα »
Cav 1.3 (CACNA1D) L-type Ca(2+) channel dysfunction in CNS disorders.
Cav 1.3 (CACNA1D) L-type Ca(2+) channel dysfunction in CNS disorders Authors: Pinggera A, Striessnig J Abstract Cav 1.3 belongs to the family of voltage-gated L-type Ca(2+) channels and is encoded by the CACNA1D gene. Cav 1.3 channels are not only essential for cardiac pacemaking, hearing and hormone secretion but are also expressed postsynaptically in neurons, where they shape neuronal firing and plasticity. Recent findings provide evidence that human mutations in the CACNA1D gene can confer risk for the development of neuropsychiatric disease and perhaps also epilepsy. Loss of Ca...περισσότερα »
Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice.
Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice Authors: Tong B, Hornak AJ, Maison SF, Ohlemiller KK, Liberman MC, Simmons DD Abstract UNLABELLED: Oncomodulin (Ocm), a member of the parvalbumin family of calcium binding proteins, is expressed predominantly by cochlear outer hair cells in subcellular regions associated with either mechanoelectric transduction or electromotility. Targeted deletion of Ocm caused progressive cochlear dysfunction. Although sound-evoked responses are normal at 1 month, by 4 months, mutants show only minimal dis... περισσότερα »
Sagittal plane momentum control during walking
in elderly fallers via Gait & Posture Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Masahiro Fujimoto, Li-Shan Chou Highlights - •We examined sagittal plane momentum control during walking. - •Regions of stability were defined using forward COM velocity and acceleration. - •COM acceleration differed even when no differences were found in COM velocity. - •Elderly fallers demonstrated the largest stability margins. - •Differences in stability margins were more pronounced when acceleration was used. AbstractObjective The purpose of th... περισσότερα »
Confirmation of PDZD7 as a Nonsyndromic Hearing Loss Gene.
Confirmation of PDZD7 as a Nonsyndromic Hearing Loss Gene.: *Confirmation of PDZD7 as a Nonsyndromic Hearing Loss Gene.* Ear Hear. 2016 Feb 4; Authors: Vona B, Lechno S, Hofrichter MA, Hopf S, Läig AK, Haaf T, Keilmann A, Zechner U, Bartsch O Abstract OBJECTIVE: PDZD7 was identified in 2009 in a family with apparent nonsyndromic sensorineural hearing loss. However, subsequent clinical reports have associated PDZD7 with digenic Usher syndrome, the most common cause of deaf-blindness, or as a modifier of retinal disease. No further reports have validated this gene for nonsyndromic ...περισσότερα »
Visual Function and Speech Perception Performance in Postlingually Deafened, Cochlear Implant Users
Cross-Modal and Intra-Modal Characteristics of Visual Function and Speech Perception Performance in Postlingually Deafened, Cochlear Implant Users: by Min-Beom Kim, Hyun-Yong Shim, Sun Hwa Jin, Soojin Kang, Jihwan Woo, Jong Chul Han, Ji Young Lee, Martha Kim, Yang-Sun Cho, Il Joon Moon, Sung Hwa Hong Evidence of visual-auditory cross-modal plasticity in deaf individuals has been widely reported. Superior visual abilities of deaf individuals have been shown to result in enhanced reactivity to visual events and/or enhanced peripheral spatial attention. The goal of this study was to ...περισσότερα »
Children with developmental coordination disorder
Light finger contact concurrently reduces postural sway and enhances signal detection performance in children with developmental coordination disorder via Gait & Posture Publication date: Available online 6 February 2016 *Source:*Gait & Posture Author(s): Fu-Chen Chen, Chia-Liang Tsai The current study examined the effects of light finger touch on postural sway and signal detection performance in children with developmental coordination disorder (DCD). Children with DCD (n=30; 18 boys, 12 girls; age=11.87±0.48 years) and typically developing children (n=30; 14 boys, 16 girls; age=11.73... περισσότερα »
Normative data on audiovisual speech integration using sentence recognition and capacity measures
Normative data on audiovisual speech integration using sentence recognition and capacity measures: Abstract *Objective*: The ability to use visual speech cues and integrate them with auditory information is important, especially in noisy environments and for hearing-impaired (HI) listeners. Providing data on measures of integration skills that encompass accuracy and processing speed will benefit researchers and clinicians. *Design*: The study consisted of two experiments: First, accuracy scores were obtained using City University of New York (CUNY) sentences, and capacity measur...περισσότερα »
Fitting recommendations and clinical benefit associated with use of the NAL-NL2 hearing-aid prescription in Nucleus cochlear implant recipients
Fitting recommendations and clinical benefit associated with use of the NAL-NL2 hearing-aid prescription in Nucleus cochlear implant recipients: Abstract *Objective*: For a group of cochlear implant recipients, who use hearing aids in the contralateral ear, the benefit of NAL-NL2 relative to a recipients’ own prescription was assessed. Whether there was a preferred frequency response and/or gain deviation from NAL-NL2 was then investigated. *Design*: Speech recognition and self-reported ratings of benefit were examined for the recipients’ own prescription compared to the NAL-NL2... περισσότερα »
The House Ear Institute–Organ of Corti 1 (HEI-OC1) is a mouse auditory cell line that endogenously express, among other several markers of cochlear hair cells, the motor protein prestin (SLC26A5).
HEI-OC1 Cells as a Model for Investigating Prestin Function via Hearing Research Publication date: Available online 6 February 2016 *Source:*Hearing Research Author(s): Channy Park, Pru Thein, Gilda Kalinec, Federico Kalinec The House Ear Institute–Organ of Corti 1 (HEI-OC1) is a mouse auditory cell line that endogenously express, among other several markers of cochlear hair cells, the motor protein prestin (SLC26A5). Since its discovery fifteen years ago, and because of the difficulties associated with working with outer hair cells, prestin studies have been performed mostly by expres...περισσότερα »
The Nucleus 22 Implant Upgrade to the Nucleus 6 System
From Pioneer to Modern Day: The Nucleus 22 Implant Upgrade to the Nucleus 6 System: Janet Clarke: It is my honor to speak to you today about the Nucleus 22 implant upgrade to the Nucleus 6 sound processor. There are several handouts available for you. Please make sure that you download those. They are also be available on myCochlear.com. The learning objectives are to ensure that we can perform these upgrades in an efficient manner to optimize patient outcomes.
Minimally Invasive Ponto Surgery on Bone Anchored Surgery
Minimally Invasive Ponto Surgery - A New Perspective on Bone Anchored Surgery: Dr. Holmberg: Today’s course will focus on why we have developed minimally invasive Ponto surgery (MIPS), how it is done, the preclinical clinical results, as well as patient benefits. We’ll start with indications and benefits of bone anchored hearing implants. Then, we will discuss the MIPS in detail, why it's done, review the new instrumentation and components, and show how surgery is performed. It may be helpful for you to explain this to patients that might be anxious about undergoing surgery. I will ... περισσότερα »
Clostridium difficile associated risk of death score (CARDS)
Clostridium difficile associated risk of death score (CARDS): a novel severity score to predict mortality among hospitalised patients with C. difficile infection: Summary Background *Clostridium difficile* infection (CDI) is a public health threat and associated with significant mortality. However, there is a paucity of objectively derived CDI severity scoring systems to predict mortality. Aims To develop a novel CDI risk score to predict mortality entitled: *Clostridium difficile* associated risk of death score (CARDS). Methods We obtained data from the United States 2011 Nationwide... περισσότερα »
Ipilimumab is a cytotoxic T-lymphocyte-associated antigen-4-blocking monoclonal antibody, which has shown a significant survival benefit in metastatic melanoma patients
Ipilimumab-Induced Gastrointestinal Toxicities: A Management Algorithm: AbstractIpilimumab is a cytotoxic T-lymphocyte-associated antigen-4-blocking monoclonal antibody, which has shown a significant survival benefit in metastatic melanoma patients. Despite being a promising therapy for a disease with an otherwise rather dismal prognosis, it is associated with several immune-related adverse effects (IRAE) mainly targeted toward the digestive tract, skin, liver, and hypothalamic-pituitary axis. Ipilimumab-induced gastrointestinal toxicity (IGT) include diarrhea (~44 %), colitis (~18... περισσότερα »
Ipilimumab-Induced Gastrointestinal Toxicities
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Ipilimumab-Induced Gastrointestinal Toxicities: A Management Algorithm: AbstractIpilimumab is a cytotoxic T-lymphocyte-associated antigen-4-blocking monoclonal antibody, which has shown a significant survival benefit in metastatic melanoma patients. Despite being a promising therapy for a disease with an otherwise rather dismal prognosis, it is associated with several immune-related adverse effects (IRAE) mainly targeted toward the digestive tract, skin, liver, and hypothalamic-pituitary axis. Ipilimumab-induced gastrointestinal toxicity (IGT) include diarrhea (~44 %), colitis (~18... περισσότερα »
Classification of vocal fold leukoplakia by clinical scoring
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Classification of vocal fold leukoplakia by clinical scoring: Abstract Background Vocal cord leukoplakia comprises a variety of lesions. The purpose of this study was to stratify vocal leukoplakias before surgery. Methods Patients with an initial diagnosis of vocal leukoplakia who underwent surgical excision at a tertiary referral center in Taiwan were recruited for this study. Their clinical records, including age, sex, preoperative laryngoscopic images in the office setting, and final pathology reports were collected and analyzed. Results Patient age (*p* = .010), nonhomogenous les... περισσότερα »
20Q: Tinnitus and Hyperacusis - Reassessment of an Old Problem
I seem to be hearing more and more about tinnitus research. Is there really that much more to learn?It's certainly true that tinnitus has been studied for some time, but yes, there still is much more to learn and much that we already know, but perhaps forgotten. Patients with tinnitus react in a complex manner involving many brain regions with different functions. The brain networks responsible for tinnitus and their relative weights create unique characteristics for each patient. The better we understand this relationship, the better we can offer assistance and treatment strategie... περισσότερα »
From Pioneer to Modern Day: The Nucleus 22 Implant Upgrade to the Nucleus 6 System
Janet Clarke: It is my honor to speak to you today about the Nucleus 22 implant upgrade to the Nucleus 6 sound processor. There are several handouts available for you. Please make sure that you download those. They are also be available on myCochlear.com. The learning objectives are to ensure that we can perform these upgrades in an efficient manner to optimize patient outcomes. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1UXizzO via IFTTT
From Pioneer to Modern Day: The Nucleus 22 Implant Upgrade to the Nucleus 6 System
Janet Clarke: It is my honor to speak to you today about the Nucleus 22 implant upgrade to the Nucleus 6 sound processor. There are several handouts available for you. Please make sure that you download those. They are also be available on myCochlear.com. The learning objectives are to ensure that we can perform these upgrades in an efficient manner to optimize patient outcomes. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1UXizzO via IFTTT
Predictable swallowing function after open horizontal supraglottic partial laryngectomy
Predictable swallowing function after open horizontal supraglottic partial laryngectomy via Auris Nasus Larynx Publication date: Available online 4 February 2016 *Source:*Auris Nasus Larynx Author(s): Christine Breunig, Philipp Benter, Rainer O. Seidl, Annekatrin Coordes ObjectiveAfter horizontal supraglottic partial laryngectomy, patients have an increased risk of dysphagia as they are not able to close the laryngeal entrance during swallowing, especially if the surgical defect of the tongue base has increased. There is no investigation that studies risk factors for impaired swallow ... περισσότερα »
Reconstruction of nasal tip support in primary, open approach septorhinoplasty
Reconstruction of nasal tip support in primary, open approach septorhinoplasty: AbstractThe reconstruction of the nasal tip support is one of the most essential issues in septorhinoplasty. A comparison of the results after using the tongue-in-groove technique and the columellar strut technique was the target of this study. Thirty-three patients who underwent a primary, open approach septorhinoplasty using the above-mentioned techniques were retrospectively analyzed. The gain in tip rotation postoperatively, the sensitivity and the rigidity of the nasal tip and the aesthetic outcome... περισσότερα »
Physical Anthropology and Osteoarchaeology in Europe
Physical Anthropology and Osteoarchaeology in Europe: History, Current Trends and Challenges: Abstract This paper provides an overview of the development and current practice of physical anthropology as relating to the treatment of archaeological skeletal remains in Europe. The evolution of physical anthropology as a discipline is covered in detail from the 18th century onwards and current trends in education and research are also discussed. Additional topics include a synthesis of the legislative framework for studying human skeletal remains in over 40 European jurisdictions, whil...περισσότερα »
Temporal course and predictive factors of analgesic opioid requirement for chemoradiation-induced oral mucositis in oropharyngeal cancer
Temporal course and predictive factors of analgesic opioid requirement for chemoradiation-induced oral mucositis in oropharyngeal cancer: Abstract Background Oral mucositis (OM)-related pain affects most patients with head and neck cancer during treatments, but its management is not standardized. Methods We retrospectively collected data about the opioid therapy used for OM-induced pain in all patients with oropharyngeal cancer treated with chemoradiotherapy (CRT) between 2009 and 2013. To compare the different opioids, a conversion into oral morphine equivalent daily dose (OMEDD) wa... περισσότερα »
ABPP Identifies TBK1 for Small Cell Lung Cancer Therapy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
To overcome hurdles in identifying key kinases in small cell lung cancer (SCLC), we integrated a target-agnostic phenotypic screen of kinase inhibitors with target identification using activity-based protein profiling (ABPP) in which a desthiobiotin-ATP probe was used. We screened 21 SCLC cell lines with known c-MYC amplification status for alterations in viability using a chemical […]
Optimization of RGD-Containing Peptides
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
We have previously reported the use of one-bead-one-compound (OBOC) combinatorial technology to develop a disulfide cyclic, Arg-Gly-Asp–containing octapeptide LXW7 (cGRGDdvc), that targets αvβ3 integrin with high affinity and specificity. αvβ3 integrin is known to be overexpressed in many cancers and in tumor vasculature, and it has been established as a cancer therapeutic target. To further […]
The HLA/MIF Complex as a Surface Target for Ovarian Cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
T cells recognize cancer cells via HLA/peptide complexes, and when disease overtakes these immune mechanisms, immunotherapy can exogenously target these same HLA/peptide surface markers. We previously identified an HLA-A2–presented peptide derived from macrophage migration inhibitory factor (MIF) and generated antibody RL21A against this HLA-A2/MIF complex. The objective of the current study was to assess the […]
Synthetic Lethality between CDK and PARP Inhibition
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
PARP1/2 are required for single-strand break repair, and their inhibition causes DNA replication fork collapse and double-strand break (DSB) formation. These DSBs are primarily repaired via homologous recombination (HR), a high-fidelity repair pathway. Should HR be deficient, DSBs may be repaired via error-prone nonhomologous end-joining mechanisms, or may persist, ultimately resulting in cell death. The […]
Selected Articles from This Issue
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/20E08ac via IFTTT
GC1118, with a Distinct EGFR-Binding Epitope and Efficacy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
The EGFR-targeted monoclonal antibodies are a valid therapeutic strategy for patients with metastatic colorectal cancer (mCRC). However, only a small subset of mCRC patients has therapeutic benefits and there are high demands for EGFR therapeutics with a broader patient pool and more potent efficacy. In this study, we report GC1118 exhibiting a different character in […]
Inhibition of Class I HDACs in Urothelial Carcinoma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Class I histone deacetylases HDAC1 and HDAC2 contribute to cell proliferation and are commonly upregulated in urothelial carcinoma. To evaluate whether specific inhibition of these enzymes might serve as an appropriate therapy for urothelial carcinoma, siRNA-mediated knockdown and specific pharmacologic inhibition of HDAC1 and HDAC2 were applied in urothelial carcinoma cell lines (UCC) with distinct […]
Inhibition of Endothelial AKT and ERK by 2-DG
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Interference with endothelial cell metabolism is a promising, yet unexploited strategy for angiogenesis inhibition. We reported that the glucose analogue 2-deoxy-D-glucose (2-DG) inhibits angiogenesis at significantly lower concentrations than those required for tumor cytotoxicity. Here, we found that hypersensitivity to 2-DG in endothelial cells is not associated with enhanced drug uptake compared with tumor cells, […]
Choline Kinase in Pancreatic Ductal Adenocarcinoma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Choline kinase α (CHKα) plays a crucial role in the regulation of membrane phospholipid synthesis and has oncogenic properties in vitro. We have analyzed the expression of CHKα in cell lines derived from pancreatic ductal adenocarcinoma (PDAC) and have found increased CHKα expression, associated with differentiation. CHKα protein expression was directly correlated with sensitivity to […]
Vocal cord leukoplakia comprises a variety of lesions. The purpose of this study was to stratify vocal leukoplakias before surgery.
Classification of vocal fold leukoplakia by clinical scoring: Abstract Background Vocal cord leukoplakia comprises a variety of lesions. The purpose of this study was to stratify vocal leukoplakias before surgery. Methods Patients with an initial diagnosis of vocal leukoplakia who underwent surgical excision at a tertiary referral center in Taiwan were recruited for this study. Their clinical records, including age, sex, preoperative laryngoscopic images in the office setting, and final pathology reports were collected and analyzed. Results Patient age (*p* = .010), nonhomogenous les... περισσότερα »
Targeted sequencing of patients with epidemiologically low-risk (ELR) head and neck squamous cell carcinoma (HNSCC) could help identify novel drivers or lost suppressors leading to precision medicine protocols and improved survival rates.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Fibroblast growth factor family aberrations as a putative driver of head and neck squamous cell carcinoma in an epidemiologically low-risk patient as defined by targeted sequencing: Abstract Background Targeted sequencing of patients with epidemiologically low-risk (ELR) head and neck squamous cell carcinoma (HNSCC) could help identify novel drivers or lost suppressors leading to precision medicine protocols and improved survival rates. Methods A patient with ELR-HNSCC was selected for targeted sequencing. We then assessed next generation sequencing cohorts from the Oncomine Powerto... περισσότερα »
Fibroblast growth factor family aberrations as a putative driver of head and neck squamous cell carcinoma in an epidemiologically low-risk patient as defined by targeted sequencing
Fibroblast growth factor family aberrations as a putative driver of head and neck squamous cell carcinoma in an epidemiologically low-risk patient as defined by targeted sequencing: Abstract Background Targeted sequencing of patients with epidemiologically low-risk (ELR) head and neck squamous cell carcinoma (HNSCC) could help identify novel drivers or lost suppressors leading to precision medicine protocols and improved survival rates. Methods A patient with ELR-HNSCC was selected for targeted sequencing. We then assessed next generation sequencing cohorts from the Oncomine Powerto... περισσότερα »
Vitamin E neuroprotection against cisplatin ototoxicity
Vitamin E neuroprotection against cisplatin ototoxicity: Preliminary results from a randomized, placebo-controlled trial: Abstract Background Few studies have investigated the effect of vitamin E in reducing the cisplatin (CDDP)-induced ototoxicity. This study evaluated vitamin E supplementation as a protecting agent against CDDP-induced ototoxicity. Methods Patients who started CDDP were randomly assigned to receive vitamin E supplementation at 400 mg per day (group 1) or placebo (group 2). Audiograms and evoked brainstem responses were obtained at baseline, and after 1, 2, and 3 m... περισσότερα »
Human papillomavirus–associated oropharyngeal squamous cell carcinoma and anogenital cancers in men: Epidemiologic evaluation of association
Human papillomavirus–associated oropharyngeal squamous cell carcinoma and anogenital cancers in men: Epidemiologic evaluation of association: Abstract Background The purpose of this study was to investigate the possible epidemiological association between oropharyngeal carcinoma and anogenital tumors. Methods Population-based demographic and pathologic data on all male patients diagnosed with oropharyngeal squamous cell carcinoma (OPSCC) and anogenital cancer between 1980 and 2011 in the province of Alberta was collected. The risk of association between anogenital cancers and OPSCCs ... περισσότερα »
Association of Fellowship Training With Otolaryngology Training Examination Scores.
Association of Fellowship Training With Otolaryngology Training Examination Scores Authors: Akinboyewa I, Cabrera-Muffly C Abstract Importance: No prior studies have evaluated whether residents who pursue fellowship training achieve higher performance on the Otolaryngology Training Examination (OTE) and whether a specific fellowship will demonstrate a correlation with the corresponding specialty-specific OTE score. Objectives: To determine whether… Continue reading Association of Fellowship Training With Otolaryngology Training Examination Scores.
Oropharyngeal carcinoma and anogenital tumors
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
Human papillomavirus–associated oropharyngeal squamous cell carcinoma and anogenital cancers in men: Epidemiologic evaluation of association by Hani Z. Marzouki, Vincent L. Biron, Jeffrey Harris, Daniel O'Connell, Hadi Seikaly via Head & Neck Abstract Background The purpose of this study was to investigate the possible epidemiological association between oropharyngeal carcinoma and anogenital tumors. Methods Population-based demographic and pathologic data on all male patients diagnosed with oropharyngeal squamous cell carcinoma (OPSCC) and anogenital cancer between 1980 and 2011 in th... περισσότερα »
Minimally Invasive Ponto Surgery - A New Perspective on Bone Anchored Surgery
Dr. Holmberg: Today's course will focus on why we have developed minimally invasive Ponto surgery (MIPS), how it is done, the preclinical clinical results, as well as patient benefits. We'll start with indications and benefits of bone anchored hearing implants. Then, we will discuss the MIPS in detail, why it's done, review the new instrumentation and components, and show how surgery is performed. It may be helpful for you to explain this to patients that might be anxious about undergoing surgery. I will also go over results from the development work and clinical work we've been d... περισσότερα »
20Q: Tinnitus and Hyperacusis - Reassessment of an Old Problem
I seem to be hearing more and more about tinnitus research. Is there really that much more to learn?It's certainly true that tinnitus has been studied for some time, but yes, there still is much more to learn and much that we already know, but perhaps forgotten. Patients with tinnitus react in a complex manner involving many brain regions with different functions. The brain networks responsible for tinnitus and their relative weights create unique characteristics for each patient. The better we understand this relationship, the better we can offer assistance and treatment strategie... περισσότερα »
From Pioneer to Modern Day: The Nucleus 22 Implant Upgrade to the Nucleus 6 System
Janet Clarke: It is my honor to speak to you today about the Nucleus 22 implant upgrade to the Nucleus 6 sound processor. There are several handouts available for you. Please make sure that you download those. They are also be available on myCochlear.com. The learning objectives are to ensure that we can perform these upgrades in an efficient manner to optimize patient outcomes. from #Audiology via ola Kala on Inoreader http://ift.tt/1UXizzO via IFTTT
Similar sensitivities and PPVs were observed between ultrasound-SPECT and ultrasound-SPECT/CT in preoperatively lateralizing parathyroid adenomas, with relatively equivalent cost-effectiveness.
Comparison of single photon emission CT (SPECT) with SPECT/CT imaging in preoperative localization of parathyroid adenomas: A cost-effectiveness analysis: Abstract Background Controversy exists regarding the superiority of single photon emission CT (SPECT)/CT over SPECT for preoperative localization of parathyroid adenomas in primary hyperparathyroidism (PHPT), as well as the cost-effectiveness. Methods A retrospective review was undertaken of patients undergoing surgery for PHPT from January 2009 to August 2014. Ultrasound and SPECT (ultrasound-SPECT) or SPECT/CT (ultrasound-SPECT/...περισσότερα »
Comparison of single photon emission CT (SPECT) with SPECT/CT imaging in preoperative localization of parathyroid adenomas: A cost-effectiveness analysis
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Comparison of single photon emission CT (SPECT) with SPECT/CT imaging in preoperative localization of parathyroid adenomas: A cost-effectiveness analysis: Abstract Background Controversy exists regarding the superiority of single photon emission CT (SPECT)/CT over SPECT for preoperative localization of parathyroid adenomas in primary hyperparathyroidism (PHPT), as well as the cost-effectiveness. Methods A retrospective review was undertaken of patients undergoing surgery for PHPT from January 2009 to August 2014. Ultrasound and SPECT (ultrasound-SPECT) or SPECT/CT (ultrasound-SPECT/...περισσότερα »
Successful detection of a minute tonsillar cancer lesion on transoral examination with narrow band imaging: A report of 2 cases
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Successful detection of a minute tonsillar cancer lesion on transoral examination with narrow band imaging: A report of 2 cases: Abstract Background The improvement of optical enhancement devices, such as narrow band imaging (NBI), has enabled us to visualize lesions that cannot be seen upon macroscopic examination. NBI is useful for detecting subtle lesions, including the primary sites of occult primary cancer. Methods and Results We describe 2 cases of tiny tonsillar cancer with positive p16 staining. Case 1 was as an occult primary cancer, and case 2 had a foreign body sensation ...περισσότερα »
We detected a small primary lesion in the palatine tonsil through transoral examination with NBI
Successful detection of a minute tonsillar cancer lesion on transoral examination with narrow band imaging: A report of 2 cases: Abstract Background The improvement of optical enhancement devices, such as narrow band imaging (NBI), has enabled us to visualize lesions that cannot be seen upon macroscopic examination. NBI is useful for detecting subtle lesions, including the primary sites of occult primary cancer. Methods and Results We describe 2 cases of tiny tonsillar cancer with positive p16 staining. Case 1 was as an occult primary cancer, and case 2 had a foreign body sensation ...περισσότερα »
Effectiveness of Low Energy Laser Treatment in Oral Mucositis Induced by Chemotherapy and Radiotherapy in Head and Neck Cancer
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Effectiveness of Low Energy Laser Treatment in Oral Mucositis Induced by Chemotherapy and Radiotherapy in Head and Neck Cancer: *Condition*: Oral Mucositis *Interventions*: Device: Low intensity laser for oral mucositis; Device: Low intensity laser for oral mucositis switch off *Sponsor*: Fundación Pública Andaluza Progreso y Salud ArmsAssigned Interventions Experimental: Low energy laser Administration of a low energy laser for oral mucositis. Device: Low intensity laser for oral mucositis Placebo Comparator: Placebo Device: Low intensity laser for oral mucositis switch of... περισσότερα »
Thyroid - Table of Contents
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer Thyroid Jan 2016, Vol. 26, No. 1: 1-133. Hypothyroidism Induces Hypophagia Associated with Alterations in Protein Expression of Neuropeptide Y and Proopiomelanocortin in the Arcuate Nucleus, Independently of Hypothalamic Nuclei-Specific Changes in Leptin Signaling Thyroid Jan 2016, Vol. 26, No. 1: 134-143. A Clinical Framework to Facilitate Risk S...περισσότερα »
Submental island flap reconstruction reduces cost in oral cancer reconstruction compared to radial forearm free flap reconstruction: a case series and cost analysis
Submental island flap reconstruction reduces cost in oral cancer reconstruction compared to radial forearm free flap reconstruction: a case series and cost analysis: - D. FornerEmail authorView ORCID ID profile, - T. Phillips, - M. Rigby, - R. Hart, - M. Taylor and - J. Trites Journal of Otolaryngology - Head & Neck Surgery201645:11 DOI: 10.1186/s40463-016-0124-8 © Forner et al. 2016 Received: 6 November 2015 Accepted: 1 February 2016 Published: 5 February 2016 Abstract Background In Canada, 4,400 cases of oral cancer are diagnosed yearly. Surgical resect... περισσότερα »
Study of CGX1321 in Subjects With Advanced Solid Tumors
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
Study of CGX1321 in Subjects With Advanced Solid Tumors: *Conditions*: Solid Tumors; Colorectal Adenocarcinoma; Gastric Adenocarcinoma; Pancreatic Adenocarcinoma; Bile Duct Carcinoma; Hepatocellular Carcinoma; Esophageal Carcinoma *Intervention*: Drug: CGX1321 *Sponsor*: Curegenix Inc. ArmsAssigned Interventions Experimental: CGX1321 Oral Dosing Dose Escalation Phase: Ascending doses of CGX1321 will be administered by cohort to determine the maximum tolerated dose. Patients will receive CGX1321 once daily, orally according to the cohort they are assigned. Dose Ex... περισσότερα »
Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face: AbstractUltraviolet light (UV) is an important risk factor for cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin. These cancers most commonly affect persons with fair skin and blue eyes who sunburn rather than suntan. However, each of these cancers appears to be associated with a different pattern of UV exposure and to be mediated by different intracellular molecular pathways. Some melanocortin 1 receptor (MC1R) gene variants play a direct role in the ...περισσότερα »
Association of Ultrasound Characteristics With Extranodal Extension in Metastatic Papillary Thyroid Carcinoma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
Association of Ultrasound Characteristics With Extranodal Extension in Metastatic Papillary Thyroid Carcinoma Authors: Qualliotine JR, Coquia SF, Hamper UM, Fakhry C Abstract Importance: The presence of extranodal extension (ENE) in metastatic papillary thyroid carcinoma (PTC) has emerged as an important prognostic factor, independently associated with tumor persistence after initial resection, decreased likelihood of complete biochemical response, and worse cause-specific survival. Therefore, the ability to determine ENE before surgery is desirable and advantageous but to date has...περισσότερα »
Leichte Hypertonie: Reichen Lebensstiländerungen allein aus?
Praxisfall Herr A. S., 47 Jahre alt, stellt sich ambulant bei allgemeinem Unwohlsein vor, möglicherweise mitbedingt durch die hohe berufliche Belastung. Seine Ehefrau hat bei ihm erhöhte Blutdruckwerte bis 160/100 mmHg gemessen. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Q4yvSH via IFTTT
Cell-intrinsic gp130 Signaling on CD4+ T cells Shapes Long-lasting Antiviral Immunity
Journal of immunology (Baltimore, Md. : 1950) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QPRy05 via IFTTT
Naturally Occurring Capsid Protein Variants of Human Papillomavirus Genotype 31 Represent a Single L1 Serotype
Journal of Virology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Q4yvSC via IFTTT
Medical Therapy of Maxillary Sinus Inflammatory Myofibroblastic Tumors
Medical Therapy of Maxillary Sinus Inflammatory Myofibroblastic Tumors: Inflammatory myofibroblastic tumor (IMT) in the maxillary sinus is a diagnostic challenge. As IMT has various names, it has various finding in magnetic resonance image. Although destructive pattern in computed tomography and hypermetabolism in PET CT suggest malignancy, it is debateful whether it is a tumor or… Continue reading Medical Therapy of Maxillary Sinus Inflammatory Myofibroblastic Tumors
Characterization of EZH2 Inhibitors in Multiple Myeloma
Multiple myeloma is a plasma cell malignancy characterized by marked heterogeneous genomic instability including frequent genetic alterations in epigenetic enzymes. In particular, the histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2) is overexpressed in multiple myeloma. EZH2 is the catalytic component of the polycomb repressive complex 2 (PRC2), a master transcriptional regulator of differentiation. EZH2… Continue reading Characterization of EZH2 Inhibitors in Multiple Myeloma
Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face
Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face: Abstract Ultraviolet light (UV) is an important risk factor for cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin. These cancers most commonly affect persons with fair skin and blue eyes who sunburn rather than suntan. However,… Continue reading Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face
In Vivo Delivery of Orlistat as Cancer Therapeutic
Triple-negative breast cancer (TNBC) is a recalcitrant malignancy with no available targeted therapy. Off-target effects and poor bioavailability of the FDA-approved antiobesity drug orlistat hinder its clinical translation as a repurposed new drug against TNBC. Here, we demonstrate a newly engineered drug formulation for packaging orlistat tailored to TNBC treatment. We synthesized TNBC-specific folate receptor–targeted… Continue reading In Vivo Delivery of Orlistat as Cancer Therapeutic
Association of Ultrasound Characteristics With Extranodal Extension in Metastatic Papillary Thyroid Carcinoma.
Association of Ultrasound Characteristics With Extranodal Extension in Metastatic Papillary Thyroid Carcinoma Authors: Qualliotine JR, Coquia SF, Hamper UM, Fakhry C Abstract Importance: The presence of extranodal extension (ENE) in metastatic papillary thyroid carcinoma (PTC) has emerged as an important prognostic factor, independently associated with tumor persistence after initial resection, decreased likelihood of complete biochemical… Continue reading Association of Ultrasound Characteristics With Extranodal Extension in Metastatic Papillary Thyroid Carcinoma.
ABPP Identifies TBK1 for Small Cell Lung Cancer Therapy
To overcome hurdles in identifying key kinases in small cell lung cancer (SCLC), we integrated a target-agnostic phenotypic screen of kinase inhibitors with target identification using activity-based protein profiling (ABPP) in which a desthiobiotin-ATP probe was used. We screened 21 SCLC cell lines with known c-MYC amplification status for alterations in viability using a chemical… Continue reading ABPP Identifies TBK1 for Small Cell Lung Cancer Therapy
Complications Following Inpatient Extracapsular Tonsillectomy in Children 36 Months and Younger.
Complications Following Inpatient Extracapsular Tonsillectomy in Children 36 Months and Younger Authors: Castaño JE, Freiser ME, Ramadan HH Abstract Importance: Tonsillectomy is among the most common surgical procedures performed by general and pediatric otolaryngologists. Inpatient surgery is generally recommended for children 36 months and younger owing to concern for a higher incidence of postoperative complications.… Continue reading Complications Following Inpatient Extracapsular Tonsillectomy in Children 36 Months and Younger.
Minimally Invasive Ponto Surgery - A New Perspective on Bone Anchored Surgery
Dr. Holmberg: Today's course will focus on why we have developed minimally invasive Ponto surgery (MIPS), how it is done, the preclinical clinical results, as well as patient benefits. We'll start with indications and benefits of bone anchored hearing implants. Then, we will discuss the MIPS in detail, why it's done, review the new instrumentation and components, and show how surgery is performed. It may be helpful for you to explain this to patients that might be anxious about undergoing surgery. I will also go over results from the development work and clinical work we've been d... περισσότερα »
20Q: Tinnitus and Hyperacusis - Reassessment of an Old Problem
I seem to be hearing more and more about tinnitus research. Is there really that much more to learn?It's certainly true that tinnitus has been studied for some time, but yes, there still is much more to learn and much that we already know, but perhaps forgotten. Patients with tinnitus react in a complex manner involving many brain regions with different functions. The brain networks responsible for tinnitus and their relative weights create unique characteristics for each patient. The better we understand this relationship, the better we can offer assistance and treatment strategie... περισσότερα »
From Pioneer to Modern Day: The Nucleus 22 Implant Upgrade to the Nucleus 6 System
Janet Clarke: It is my honor to speak to you today about the Nucleus 22 implant upgrade to the Nucleus 6 sound processor. There are several handouts available for you. Please make sure that you download those. They are also be available on myCochlear.com. The learning objectives are to ensure that we can perform these upgrades in an efficient manner to optimize patient outcomes. from #Audiology via xlomafota13 on Inoreader http://ift.tt/1UXizzO via IFTTT
Thyroid Hormone Receptors Are Differentially Expressed in Granulosa and Cervical Cells of Infertile Women
Thyroid Hormone Receptors Are Differentially Expressed in Granulosa and Cervical Cells of Infertile Women: Thyroid , Vol. 0, No. 0. Author information Eva López Navarro,1 Francisco J. Ortega,2,3 Eugènia Francisco-Busquets,4 Mònica Sabater-Masdeu,2,3Elena Álvarez-Castaño,1 Wifredo Ricart,2,3 and José M. Fernández-Real2,3 1Obstetrics and Gynecology Service, Institut d'Investigació Biomèdica de Girona (IdIBGi), Girona, Spain. 2Department of Diabetes, Endocrinology, and Nutrition (UDEN), Institut d'Investigació Biomèdica de Girona (IdIBGi), Girona, Spain. 3CIBERobn Pathophysiology of O...περισσότερα »
Successful Endovascular Management of Venous Sinus Thrombosis Complicating Trans-Labyrinthine Removal Of Vestibular Schwanomma
Successful Endovascular Management of Venous Sinus Thrombosis Complicating Trans-Labyrinthine Removal Of Vestibular Schwanomma: Cerebral venous sinus thrombosis (CVST) is a rare complication of surgical treatment of vestibular schwanomma. We present a rare case of extensive venous sinus thrombosis after trans-labyrinthine approach that was refractory to systemic anti-coagulation. Mechanical aspiration thrombectomy was utilized to re-canalize the venous sinuses and resulted in successful resolution of neurological symptoms. Indications of utilizing endovascular approaches are discuss... περισσότερα »
Medical Therapy of Maxillary Sinus Inflammatory Myofibroblastic Tumors
Medical Therapy of Maxillary Sinus Inflammatory Myofibroblastic Tumors: Inflammatory myofibroblastic tumor (IMT) in the maxillary sinus is a diagnostic challenge. As IMT has various names, it has various finding in magnetic resonance image. Although destructive pattern in computed tomography and hypermetabolism in PET CT suggest malignancy, it is debateful whether it is a tumor or inflammatory lesion. Treatment of IMT usually includes surgery. However, IMT can be dealed with medical treatment according to histologic type and localization. We report a rare case of IMT in the maxillar... περισσότερα »
American Journal of Otolaryngology
Are neutrophil-, eosinophil-, and basophil-to-lymphocyte ratios useful markers for pinpointing patients at higher risk of recurrent sinonasal polyps? Despite advances in the diagnosis and treatment of chronic rhinosinusitis with nasal polyps (CRSwNP), their recurrence rate remains significant. There is a need for promptly-obtainable, inexpensive, minimally-invasive prognostic parameters to enable rhinologists to identify patients at higher risk of recurrent CRSwNP. The prognostic role of the neutrophil-to-lymphocyte ratio (NLR) and eosinophil-to-lymphocyte ratio (ELR), previously d... περισσότερα »
The heterogeneous prognostic role of NLR, ELR and BLR identified in the clinically and pathologically different sub-cohorts of CRSwNP considered supports the hypothesis that CRSwNPs with a similar clinical picture may differ considerably in terms of the biological and pathogenic mechanisms of polyp formation and growth.
Are neutrophil-, eosinophil-, and basophil-to-lymphocyte ratios useful markers for pinpointing patients at higher risk of recurrent sinonasal polyps?: Despite advances in the diagnosis and treatment of chronic rhinosinusitis with nasal polyps (CRSwNP), their recurrence rate remains significant. There is a need for promptly-obtainable, inexpensive, minimally-invasive prognostic parameters to enable rhinologists to identify patients at higher risk of recurrent CRSwNP. The prognostic role of the neutrophil-to-lymphocyte ratio (NLR) and eosinophil-to-lymphocyte ratio (ELR), previously d... περισσότερα »
SIgA levels in the nasal fluid are significantly reduced in children with AR independent of treatment and are negatively correlated with the Total symptom scores (TSS)
Nasal fluid secretory immunoglobulin A levels in children with allergic rhinitis via International Journal of Pediatric Otorhinolaryngology Publication date: April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): Fatih Dilek, Emin Ozkaya, Bilge Gultepe, Mebrure Yazici, Meryem Iraz ObjectivesThere is growing knowledge about the immunoregulatory and possibly preventative roles of immunoglobulin A (IgA) in allergic diseases. This study aimed to investigate secretory immunoglobulin A (SIgA) levels in the nasal fluid of children who were either bei... περισσότερα »
Pycnodysostosis presenting as atypical stridor
Pycnodysostosis presenting as atypical stridor via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 5 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): L. Manfredi, S. Marlin, B. Fauroux, N. Garabedian, V. Couloigner, N. Leboulanger ObjectivesPycnodysostosis is a rare genetic disorder caused by a mutation of the cathepsin K gene involved in bone turnover. It is responsible, in particular, for a combination of dwarfism and bone fragility. Upper airway obstruction may be observed, but associate... περισσότερα »
Cervical tuberculous lymphadenitis – The role of neck dissection
A clinical review of 38 cases of cervical tuberculous lymphadenitis in Japan – The role of neck dissection via Auris Nasus Larynx Publication date: Available online 5 February 2016 *Source:*Auris Nasus Larynx Author(s): Sayaka Omura, Muneo Nakaya, Ayumi Mori, Mineko Oka, Akiko Ito, Wataru Kida, Yasuhiro Inayoshi, Aki Inoue, Teruhiko Fuchigami, Mikio Takamori ObjectivesAfter tuberculous pleurisy, lymphadenitis arising from cervical lesion is the second most common form of extrapulmonary tuberculosis. It is generally treated with antituberculosis agents, but some patients resist chemoth...περισσότερα »
Acquired stenosis of the external auditory canal (EAC) : Chronic ulcerated lesions affecting the EAC and auricles can be secondary to several diseases, including malignant external otitis, skin infection (fungal, mycobacterial or viral), insect bites, lymphoma, cutaneous primary tumor, metastasis, perichondritis, vasculitis, Wegner's granulomatosis, artifact dermatitis, neurodermatitis and pyoderma gangrenosum.
*Case report* Acquired stenosis of external auditory canal secondary to paraneoplastic manifestation of renal cancer *Estenose adquirida do conduto auditivo externo secundária a manifestação paraneoplásica de câncer renal* *- Loraine Entringer Falquetoa, - Marcos Lyra Kaddoumb, - Marcio Maia Lamy de Mirandaa, - Henrique Faria Ramosa, , * - *a Universidade Federal do Espírito Santo (UFES), Vitoria, ES, Brazil* - *b Department of Urology, Universidade Federal do Espírito Santo (UFES), Hospital Cassiano Antônio de Morais, Vitoria, ES, Brazil* *doi:10.1016/j.bjorl.2015.1... περισσότερα »
Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face
Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face: AbstractUltraviolet light (UV) is an important risk factor for cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin. These cancers most commonly affect persons with fair skin and blue eyes who sunburn rather than suntan. However, each of these cancers appears to be associated with a different pattern of UV exposure and to be mediated by different intracellular molecular pathways. Some melanocortin 1 receptor (MC1R) gene variants play a direct role in the ...περισσότερα »
Cross-Modal and Intra-Modal Characteristics of Visual Function and Speech Perception Performance in Postlingually Deafened, Cochlear Implant Users
Cross-Modal and Intra-Modal Characteristics of Visual Function and Speech Perception Performance in Postlingually Deafened, Cochlear Implant Users: by Min-Beom Kim, Hyun-Yong Shim, Sun Hwa Jin, Soojin Kang, Jihwan Woo, Jong Chul Han, Ji Young Lee, Martha Kim, Yang-Sun Cho, Il Joon Moon, Sung Hwa Hong Evidence of visual-auditory cross-modal plasticity in deaf individuals has been widely reported. Superior visual abilities of deaf individuals have been shown to result in enhanced reactivity to visual events and/or enhanced peripheral spatial attention. The goal of this study was to ...περισσότερα »
Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face
Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face: AbstractUltraviolet light (UV) is an important risk factor for cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin. These cancers most commonly affect persons with fair skin and blue eyes who sunburn rather than suntan. However, each of these cancers appears to be associated with a different pattern of UV exposure and to be mediated by different intracellular molecular pathways. Some melanocortin 1 receptor (MC1R) gene variants play a direct role in the ...περισσότερα »
Association of Fellowship Training With Otolaryngology Training Examination Scores.
Association of Fellowship Training With Otolaryngology Training Examination Scores Authors: Akinboyewa I, Cabrera-Muffly C Abstract Importance: No prior studies have evaluated whether residents who pursue fellowship training achieve higher performance on the Otolaryngology Training Examination (OTE) and whether a specific fellowship will demonstrate a correlation with the corresponding specialty-specific OTE score. Objectives: To determine whether residents pursuing fellowship training achieve higher performance on the OTE and whether fellowship choice is correlated with higher s...περισσότερα »
A Cross Modal Performance-Based Measure of Sensory Stimuli Intricacy
*A Cross Modal Performance-Based Measure of Sensory Stimuli Intricacy: * *by Kobi Snitz, Anat Arzi, Merav Jacobson, Lavi Secundo, Kineret Weissler, Adi Yablonka* Abstract *We define a new measure of sensory stimuli which has the following properties: It is cross modal, performance based, robust, and well defined. We interpret this measure as the intricacy or complexity of the stimuli, yet its validity is independent of its interpretation. We tested the validity and cross modality of our measure using three olfactory and one visual experiment. In order to test the link between our ... περισσότερα »
The change of hippocampal volume and its relevance with inner ear function in Meniere's disease patients
The change of hippocampal volume and its relevance with inner ear function in Meniere's disease patients via Auris Nasus Larynx Publication date: Available online 6 February 2016 *Source:*Auris Nasus Larynx Author(s): Young Joon Seo, Jinna Kim, Sung Huhn Kim ObjectivesTo reveal the relationship between the disease progression and the hippocampal volume in Meniere's disease, which may indirectly reflect the degree of patients’ chronic exposure to stress.MethodsRetrospective review of medical records and brain magnetic resonance image (MRI) of Meniere's disease patients and healthy contr...περισσότερα »
The management of peritonsillar abscess : Although empirical antibiotic therapy was effective for most of the PTA patients, bacteriologic studies might be indispensable for the patients with laryngeal edema considering the failure of the first treatments
The role of bacteriological studies in the management of peritonsillar abscess via Auris Nasus Larynx Publication date: Available online 6 February 2016 *Source:*Auris Nasus Larynx Author(s): Tomoyasu Tachibana, Yorihisa Orita, Soshi Takao, Yuya Ogawara, Yuko Matsuyama, Aiko Shimizu, Iku Abe-Fujisawa, Michihiro Nakada, Yasuharu Sato, Kazunori Nishizaki ObjectiveSince most patients with peritonsillar abscess (PTA) can be successfully treated with surgical drainage and empirical antibiotic therapy, routine bacteriologic studies for all patients with PTA may be unnecessary. This study tr...περισσότερα »
Stria vascularis and cochlear hair cell changes in syphilis
: A human temporal bone study via Auris Nasus Larynx Publication date: Available online 6 February 2016 *Source:*Auris Nasus Larynx Author(s): Ömer Hızlı, Serdar Kaya, Pelin Hızlı, Michael M. Paparella, Sebahattin Cureoglu ObjectiveTo observe any changes in stria vascularis and cochlear hair cells in patients with syphilis.Materials and methodsWe examined 13 human temporal bone samples from 8 patients with syphilis (our syphilis group), as well as 12 histopathologically normal samples from 9 age-matched patients without syphilis (our control group). We compared, between the two groups...περισσότερα »
Cancer stem cell in radioresistant head and neck cancer
Role of via Auris Nasus Larynx Publication date: Available online 6 February 2016 *Source:*Auris Nasus Larynx Author(s): Young Min Park, Sei Young Lee, Suk Won Park, Se-Heon Kim ObjectiveRadioresistance is the main determinant of treatment outcome in head and neck cancer. The aim of this study was to establish radioresistant head and neck cancer cell lines and isolate cancer stem cells from them to investigate the role of cancer stem cells in radioresistant head and neck cancer.MethodsTo induce radioresistant cell lines, radiation was delivered to SCC15, SCC25, and QLL1 cells with an ... περισσότερα »
Cavernous sinus thrombosis secondary to aspergillus granuloma
: A case report and review of the literature via Auris Nasus Larynx Publication date: Available online 6 February 2016 *Source:*Auris Nasus Larynx Author(s): Esteban Brenet, Camille Boulagnon-Rombi, Yohan N’guyen, Claude-Fabien Litré Cavernous sinus thrombosis is a rare but serious complication of sphenoid aspergillosis. The rarity of this pathology makes its diagnostic very difficult on a clinical, biological and radiological sense. The authors present a case of cavernous sinus thrombosis with ipsilateral internal carotid artery thrombosis secondary to a non-invasive sphenoid aspergi... περισσότερα »
Cancer stem cell in radioresistant head and neck cancer
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
Role of cancer stem cell in radioresistant head and neck cancer via Auris Nasus Larynx Publication date: Available online 6 February 2016 *Source:*Auris Nasus Larynx Author(s): Young Min Park, Sei Young Lee, Suk Won Park, Se-Heon Kim ObjectiveRadioresistance is the main determinant of treatment outcome in head and neck cancer. The aim of this study was to establish radioresistant head and neck cancer cell lines and isolate cancer stem cells from them to investigate the role of cancer stem cells in radioresistant head and neck cancer.MethodsTo induce radioresistant cell lines, radiation ...περισσότερα »
Intralesional cidofovir injection for recurrent respiratory papillomatosis
in Japan via Auris Nasus Larynx Publication date: Available online 6 February 2016 *Source:*Auris Nasus Larynx Author(s): Shigeyuki Murono, Yosuke Nakanishi, Akira Tsuji, Kazuhira Endo, Satoru Kondo, Naohiro Wakisaka, Tomokazu Yoshizaki ObjectiveThe treatment of recurrent respiratory papillomatosis (RRP) continues to be difficult. Adjuvant pharmacological treatment is increasingly being used, and intralesional cidofovir injection remains the leading option. Almost all papers regarding the treatment come from the United States and Europe. The present study demonstrated it for the first...περισσότερα »
Nasal septum deviation and maxillary transversal deficiency
Is there a correlation between nasal septum deviation and maxillary transversal deficiency? A retrospective study on prepubertal subjects via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 6 February 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Ballanti Fabiana, Baldini Alberto, Ranieri Salvatore, Nota Alessandro, Cozza Paola IntroductionDeviated nasal septum may cause a reduction of the nasal airflow, thus, during the craniofacial development, a reduced nasal airflow could originate a chronic mouth-breathing ... περισσότερα »
In otitis media with effusion (OME), hearing loss
Precision-scored parental report questions and HL-scaled tympanometry as informative measures of hearing in otitis media 1: large-sample evidence on determinants and complementarity to pure-tone audiometry via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 6 February 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Jovica Milovanovic, Snezana A. Filipovic, Paola Marchisio, Mark P. Haggard, Mary F. Zhang, Helen Spencer IntroductionIn otitis media with effusion (OME), hearing loss is a core sign/symptom and basis of...περισσότερα »
Polysomnography with a capped tracheostomy tube is a useful, objective tool to complement endoscopy and functional airway assessment in the consideration of decannulation in the paediatric population.
The Role of Polysomnography in Tracheostomy Decannulation of the Paediatric Patient via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 6 February 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Jennifer Lee, Marlene A. Soma, Arthur Y. Teng, Ganesh Thambipillay, Karen A. Waters, Alan T. Cheng IntroductionTracheostomy decannulation in the paediatric patient is usually considered when there is resolution or significant improvement in the original indication for the tracheostomy. The child's cardiorespiratory functi...περισσότερα »
Sleep-disordered breathing in children with Down syndrome
: Usefulness of home polysomnography via International Journal of Pediatric Otorhinolaryngology Publication date: April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): Pablo E. Brockmann, Felipe Damiani, Felipe Nuñez, Ana Moya, Eduardo Pincheira, Maria A. Paul, Macarena Lizama ObjectiveTo investigate the technical feasibility of unattended home polysomnography (HPSG) in children with Down syndrome.MethodsData from children with Down syndrome under 10 years of age referred to a diagnostic sleep study was analyzed. A full sleep-lab based polysomn... περισσότερα »
Adaptation and Validation of Common Object Token (COT) Test
into the Sinhalese Language via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 6 February 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Janani Jeyaraman, Chameera Kumarasinghe, Shabnam Fathima Mohamed Rafi, Thirimadura Lakna Amalie Mendis, Abdul Rasheed Fathima Shameema ObjectivesThis manuscript presents a translation and adaptation of the Common Object Token (COT) test, which assesses speech perception, into the Sinhalese language and an attempt to validate it for use on children with normal hearing (NH) and ... περισσότερα »
Margin to tumor thickness ratio – A predictor of local recurrence and survival in oral squamous cell carcinoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Margin to tumor thickness ratio – A predictor of local recurrence and survival in oral squamous cell carcinoma via ScienceDirect Publication: Oral Oncology Publication date: Available online 6 February 2016 *Source:*Oral Oncology Author(s): Gregor Heiduschka, Sohaib A. Virk, Carsten E. Palme, Sydney Ch’ng, Michael Elliot, Ruta Gupta, Jonathan Clark ObjectivesTo assess whether small oral squamous cell carcinomas (OSCC) require the same margin clearance as large tumors. We evaluated the association between the ratio of the closest margin to tumor size (MSR) and tumor thickness (MTR) with... περισσότερα »
Margin to tumor thickness ratio – A predictor of local recurrence and survival in oral squamous cell carcinoma
Margin to tumor thickness ratio – A predictor of local recurrence and survival in oral squamous cell carcinoma via ScienceDirect Publication: Oral Oncology Publication date: Available online 6 February 2016 *Source:*Oral Oncology Author(s): Gregor Heiduschka, Sohaib A. Virk, Carsten E. Palme, Sydney Ch’ng, Michael Elliot, Ruta Gupta, Jonathan Clark ObjectivesTo assess whether small oral squamous cell carcinomas (OSCC) require the same margin clearance as large tumors. We evaluated the association between the ratio of the closest margin to tumor size (MSR) and tumor thickness (MTR) with... περισσότερα »
Preserved Dendritic Cell HLA-DR Expression and Reduced Regulatory T Cell Activation in Asymptomatic Plasmodium falciparum and P. vivax Infection
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 58 δευτερόλεπτα
Infection and Immunity from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Q4wYfl via IFTTT
Symptom lead times in lung and colorectal cancers: what are the benefits of symptom-based approaches to early diagnosis?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 58 δευτερόλεπτα
British Journal of Cancer from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QPQ5H6 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Underestimation of the true specificity of the urine lipoarabinomannan (LAM) point-of-care diagnostic assay for HIV-associated tuberculosis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 58 δευτερόλεπτα
Journal of acquired immune deficiency syndromes (1999) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Q4wXZ3 via IFTTT
Re-defining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 58 δευτερόλεπτα
Nature reviews. Neuroscience from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QPQ71y via IFTTT
An Inheritable Variant of the Innate Immune Receptor Melanoma Differentiation-Associated Gene 5 Promotes Clearance of Hepatitis C Virus
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 58 δευτερόλεπτα
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Use of stop-smoking medications in the United States before and after the introduction of varenicline
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 58 δευτερόλεπτα
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Imaging tumour hypoxia with positron emission tomography
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 58 δευτερόλεπτα
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Symptom lead times in lung and colorectal cancers: what are the benefits of symptom-based approaches to early diagnosis?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 58 δευτερόλεπτα
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Characterization of EZH2 Inhibitors in Multiple Myeloma
Multiple myeloma is a plasma cell malignancy characterized by marked heterogeneous genomic instability including frequent genetic alterations in epigenetic enzymes. In particular, the histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2) is overexpressed in multiple myeloma. EZH2 is the catalytic component of the polycomb repressive complex 2 (PRC2), a master transcriptional regulator of differentiation. EZH2 catalyzes methylation of lysine 27 on histone H3 and its deregulation in cancer has been reported to contribute to silencing of tumor suppressor genes, resulting in a m...περισσότερα »
In Vivo Delivery of Orlistat as Cancer Therapeutic
Triple-negative breast cancer (TNBC) is a recalcitrant malignancy with no available targeted therapy. Off-target effects and poor bioavailability of the FDA-approved antiobesity drug orlistat hinder its clinical translation as a repurposed new drug against TNBC. Here, we demonstrate a newly engineered drug formulation for packaging orlistat tailored to TNBC treatment. We synthesized TNBC-specific folate receptor–targeted micellar nanoparticles (NP) carrying orlistat, which improved the solubility (70–80 μg/mL) of this water-insoluble drug. The targeted NPs also improved the delive... περισσότερα »
ABPP Identifies TBK1 for Small Cell Lung Cancer Therapy
To overcome hurdles in identifying key kinases in small cell lung cancer (SCLC), we integrated a target-agnostic phenotypic screen of kinase inhibitors with target identification using activity-based protein profiling (ABPP) in which a desthiobiotin-ATP probe was used. We screened 21 SCLC cell lines with known c-MYC amplification status for alterations in viability using a chemical library of 235 small-molecule kinase inhibitors. One screen hit compound was interrogated with ABPP, and, through this approach, we reidentified Aurora kinase B as a critical kinase in MYC-amplified SCL... περισσότερα »
Optimization of RGD-Containing Peptides
We have previously reported the use of one-bead-one-compound (OBOC) combinatorial technology to develop a disulfide cyclic, Arg-Gly-Asp–containing octapeptide LXW7 (cGRGDdvc), that targets αvβ3 integrin with high affinity and specificity. αvβ3 integrin is known to be overexpressed in many cancers and in tumor vasculature, and it has been established as a cancer therapeutic target. To further optimize LXW7, we have performed systematic structure–activity relationship studies. On the basis of the results, two highly focused OBOC peptide libraries were designed, synthesized, and scre...περισσότερα »
The HLA/MIF Complex as a Surface Target for Ovarian Cancer
T cells recognize cancer cells via HLA/peptide complexes, and when disease overtakes these immune mechanisms, immunotherapy can exogenously target these same HLA/peptide surface markers. We previously identified an HLA-A2–presented peptide derived from macrophage migration inhibitory factor (MIF) and generated antibody RL21A against this HLA-A2/MIF complex. The objective of the current study was to assess the potential for targeting the HLA-A2/MIF complex in ovarian cancer. First, MIF peptide FLSELTQQL was eluted from the HLA-A2 of the human cancerous ovarian cell lines SKOV3, A27... περισσότερα »
Synthetic Lethality between CDK and PARP Inhibition
PARP1/2 are required for single-strand break repair, and their inhibition causes DNA replication fork collapse and double-strand break (DSB) formation. These DSBs are primarily repaired via homologous recombination (HR), a high-fidelity repair pathway. Should HR be deficient, DSBs may be repaired via error-prone nonhomologous end-joining mechanisms, or may persist, ultimately resulting in cell death. The combined disruption of PARP and HR activities thus produces synthetic lethality. Multiple myeloma cells are characterized by chromosomal instability and pervasive DNA damage, impl...περισσότερα »
Selected Articles from This Issue
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GC1118, with a Distinct EGFR-Binding Epitope and Efficacy
The EGFR-targeted monoclonal antibodies are a valid therapeutic strategy for patients with metastatic colorectal cancer (mCRC). However, only a small subset of mCRC patients has therapeutic benefits and there are high demands for EGFR therapeutics with a broader patient pool and more potent efficacy. In this study, we report GC1118 exhibiting a different character in terms of binding epitope, affinity, mode of action, and efficacy from other anti-EGFR antibodies. Structural analysis of the EGFR–GC1118 crystal complex revealed that GC1118 recognizes linear, discrete N-terminal epit...περισσότερα »
Inhibition of Class I HDACs in Urothelial Carcinoma
Class I histone deacetylases HDAC1 and HDAC2 contribute to cell proliferation and are commonly upregulated in urothelial carcinoma. To evaluate whether specific inhibition of these enzymes might serve as an appropriate therapy for urothelial carcinoma, siRNA-mediated knockdown and specific pharmacologic inhibition of HDAC1 and HDAC2 were applied in urothelial carcinoma cell lines (UCC) with distinct HDAC1 and HDAC2 expression profiles. HDACs and response marker proteins were followed by Western blotting and qRT-PCR. Effects of class I HDAC suppression on UCCs were analyzed by viab... περισσότερα »
Inhibition of Endothelial AKT and ERK by 2-DG
Interference with endothelial cell metabolism is a promising, yet unexploited strategy for angiogenesis inhibition. We reported that the glucose analogue 2-deoxy-D-glucose (2-DG) inhibits angiogenesis at significantly lower concentrations than those required for tumor cytotoxicity. Here, we found that hypersensitivity to 2-DG in endothelial cells is not associated with enhanced drug uptake compared with tumor cells, but with time-dependent, endothelial-selective inhibition of AKT and ERK phosphorylation. Downregulation of these critical survival pathways is shown to be due to 2-DG... περισσότερα »
Choline Kinase in Pancreatic Ductal Adenocarcinoma
Choline kinase α (CHKα) plays a crucial role in the regulation of membrane phospholipid synthesis and has oncogenic properties *in vitro*. We have analyzed the expression of CHKα in cell lines derived from pancreatic ductal adenocarcinoma (PDAC) and have found increased CHKα expression, associated with differentiation. CHKα protein expression was directly correlated with sensitivity to MN58b, a CHKα inhibitor that reduced cell growth through the induction of apoptosis. Accordingly, CHKα knockdown led to reduced drug sensitivity. In addition, we found that gemcitabine-resistant PDA...περισσότερα »
Nuclear RON in NHEJ DNA Repair
Tumor hypoxia is associated with radioresistance, chemoresistance, and metastasis, which eventually lead to cancer progression and a poor patient prognosis. RON [also known as macrophage-stimulating protein receptor (MST1R)] belongs to the c-MET [also known as hepatocyte growth factor receptor (HGFR)] receptor tyrosine kinase (RTK) superfamily. To identify the interaction partners of RON nuclear translocation in response to hypoxia, the nuclear extract of TSGH8301 bladder cancer cells was immunoprecipitated for tandem mass profiling analysis. Nuclear RON interacted with adenosine ...περισσότερα »
Retraction: Pharmacologic Inactivation of Kinase Suppressor of Ras1 Sensitizes Epidermal Growth Factor Receptor and Oncogenic Ras-Dependent Tumors to Ionizing Radiation Treatment
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ABT-414, an Antibody Drug Conjugate Targeting a Tumor-Selective EGFR Epitope
Targeting tumor overexpressed epidermal growth factor receptor with an antibody drug conjugate is an attractive therapeutic strategy; however, normal tissue expression represents a significant toxicity risk. The anti-EGFR antibody ABT-806 targets a unique tumor-specific epitope and exhibits minimal reactivity to EGFR in normal tissue suggesting its suitability for the development of an ADC. We describe the binding properties and preclinical activity of ABT-414, an ABT-806 monomethyl auristatin F conjugate. In vitro, ABT-414 selectively kills tumor cells overexpressing wild-type or... περισσότερα »
Targeting Interleukin-11 Receptor-{alpha} Impairs Human Endometrial Cancer Cell Proliferation and Invasion in vitro and Reduces Tumour Growth and Metastasis in vivo.
Endometrial cancer contributes to significant morbidity and mortality in women with advanced stage or recurrent disease. Interleukin (IL)11 is a cytokine that regulates cell cycle, invasion and migration, all hallmarks of cancer. IL11 is elevated in endometrial tumours and uterine lavage fluid in women with endometrial cancer, alters endometrial epithelial cancer cell adhesion and migration in vitro but its role in endometrial tumourigenesis in vivo is unknown. We injected mice subcutaneously with human-derived Ishikawa or HEC1A endometrial epithelial cancer cells (ectopic), or HEC... περισσότερα »
Characterization of EZH2 Inhibitors in Multiple Myeloma
Multiple myeloma is a plasma cell malignancy characterized by marked heterogeneous genomic instability including frequent genetic alterations in epigenetic enzymes. In particular, the histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2) is overexpressed in multiple myeloma. EZH2 is the catalytic component of the polycomb repressive complex 2 (PRC2), a master transcriptional regulator of differentiation. EZH2… Continue reading Characterization of EZH2 Inhibitors in Multiple Myeloma
In Vivo Delivery of Orlistat as Cancer Therapeutic
Triple-negative breast cancer (TNBC) is a recalcitrant malignancy with no available targeted therapy. Off-target effects and poor bioavailability of the FDA-approved antiobesity drug orlistat hinder its clinical translation as a repurposed new drug against TNBC. Here, we demonstrate a newly engineered drug formulation for packaging orlistat tailored to TNBC treatment. We synthesized TNBC-specific folate receptor–targeted… Continue reading In Vivo Delivery of Orlistat as Cancer Therapeutic
ABPP Identifies TBK1 for Small Cell Lung Cancer Therapy
To overcome hurdles in identifying key kinases in small cell lung cancer (SCLC), we integrated a target-agnostic phenotypic screen of kinase inhibitors with target identification using activity-based protein profiling (ABPP) in which a desthiobiotin-ATP probe was used. We screened 21 SCLC cell lines with known c-MYC amplification status for alterations in viability using a chemical… Continue reading ABPP Identifies TBK1 for Small Cell Lung Cancer Therapy
Optimization of RGD-Containing Peptides
We have previously reported the use of one-bead-one-compound (OBOC) combinatorial technology to develop a disulfide cyclic, Arg-Gly-Asp–containing octapeptide LXW7 (cGRGDdvc), that targets αvβ3 integrin with high affinity and specificity. αvβ3 integrin is known to be overexpressed in many cancers and in tumor vasculature, and it has been established as a cancer therapeutic target. To further… Continue reading Optimization of RGD-Containing Peptides
The HLA/MIF Complex as a Surface Target for Ovarian Cancer
T cells recognize cancer cells via HLA/peptide complexes, and when disease overtakes these immune mechanisms, immunotherapy can exogenously target these same HLA/peptide surface markers. We previously identified an HLA-A2–presented peptide derived from macrophage migration inhibitory factor (MIF) and generated antibody RL21A against this HLA-A2/MIF complex. The objective of the current study was to assess the… Continue reading The HLA/MIF Complex as a Surface Target for Ovarian Cancer
Synthetic Lethality between CDK and PARP Inhibition
PARP1/2 are required for single-strand break repair, and their inhibition causes DNA replication fork collapse and double-strand break (DSB) formation. These DSBs are primarily repaired via homologous recombination (HR), a high-fidelity repair pathway. Should HR be deficient, DSBs may be repaired via error-prone nonhomologous end-joining mechanisms, or may persist, ultimately resulting in cell death. The… Continue reading Synthetic Lethality between CDK and PARP Inhibition
Selected Articles from This Issue
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GC1118, with a Distinct EGFR-Binding Epitope and Efficacy
The EGFR-targeted monoclonal antibodies are a valid therapeutic strategy for patients with metastatic colorectal cancer (mCRC). However, only a small subset of mCRC patients has therapeutic benefits and there are high demands for EGFR therapeutics with a broader patient pool and more potent efficacy. In this study, we report GC1118 exhibiting a different character in… Continue reading GC1118, with a Distinct EGFR-Binding Epitope and Efficacy
Inhibition of Class I HDACs in Urothelial Carcinoma
Class I histone deacetylases HDAC1 and HDAC2 contribute to cell proliferation and are commonly upregulated in urothelial carcinoma. To evaluate whether specific inhibition of these enzymes might serve as an appropriate therapy for urothelial carcinoma, siRNA-mediated knockdown and specific pharmacologic inhibition of HDAC1 and HDAC2 were applied in urothelial carcinoma cell lines (UCC) with distinct… Continue reading Inhibition of Class I HDACs in Urothelial Carcinoma
Inhibition of Endothelial AKT and ERK by 2-DG
Interference with endothelial cell metabolism is a promising, yet unexploited strategy for angiogenesis inhibition. We reported that the glucose analogue 2-deoxy-D-glucose (2-DG) inhibits angiogenesis at significantly lower concentrations than those required for tumor cytotoxicity. Here, we found that hypersensitivity to 2-DG in endothelial cells is not associated with enhanced drug uptake compared with tumor cells,… Continue reading Inhibition of Endothelial AKT and ERK by 2-DG
Effective concentration of a multi-kinase inhibitor within bone marrow correlates with in vitro cell killing in therapy-resistant chronic myeloid leukemia
Leukemia cells escape BCR-ABL-targeted therapy by developing mutations such as T315I in the p210BCR-ABL fusion protein in Philadelphia chromosome-positive chronic myeloid leukemia (CML). While most effort has been focused on development of new tyrosine kinase inhibitors (TKIs), enrichment of these small molecule inhibitors in the tumor tissue can also have a profound impact on treatment outcomes. Here, we report that a 2-hour exposure of the T315I mutant CML cells to 10 μM of the multi-kinase inhibitor TG101209 suppressed BCR-ABL-independent signaling and caused cell cycle arrest ...περισσότερα »
Intermittent high dose scheduling of AZD8835, a novel selective inhibitor of PI3K{alpha} and PI3K{delta}, demonstrates treatment strategies for PIK3CA-dependent breast cancers
The PIK3CA gene, encoding the p110α catalytic unit of PI3Kα is one of the most frequently mutated oncogenes in human cancer. Hence PI3Kα is a target subject to intensive efforts in identifying inhibitors and evaluating their therapeutic potential. Here we report studies with a novel PI3K inhibitor, AZD8835, currently in Phase I clinical evaluation. AZD8835 is a potent inhibitor of PI3Kα and PI3K with selectivity vs. PI3Kβ, PI3K and other kinases that preferentially inhibited growth in cells with mutant PIK3CA status, such as in ER+ breast cancer cell lines BT474, MCF7 and T47D (su... περισσότερα »
Antagonizing the Hedgehog Pathway with Vismodegib Impairs Malignant Pleural Mesothelioma Growth In Vivo by Affecting Stroma
An autocrine driven upregulation of the Hedgehog (Hh) signaling pathway has been described in malignant pleural mesothelioma (MPM), in which the ligand, desert hedgehog (DHH), was produced from tumor cells. However, our investigation revealed that the Hh pathway is activated in both tumor and stroma of MPM tumor specimens and an orthotopic immunocompetent rat MPM model. This was demonstrated by positive immunohistochemical staining of Glioma associated oncogene 1 (GLI1) and Patched1 (PTCH1) in both tumor and stromal fractions. DHH was predominantly expressed in the tumor fractions.... περισσότερα »
Combined Effects of Suberoylanilide Hydroxamic Acid and Cisplatin on Radiation Sensitivity and Cancer Cell Invasion in Non-small-cell Lung Cancer
Lung cancer is a leading cause of cancer mortality worldwide, and concurrent chemoradiotherapy has been explored as a therapeutic option. However, the chemotherapeutic agents cannot be administered for most patients at full doses safely with radical doses of thoracic radiation, and further optimizations of chemotherapy regimen to be given with radiation are needed. In this study, we examined the effects of suberoylanilide hydroxamic acid (SAHA) and cisplatin on DNA damage repairs, and determined the combination effects of SAHA and cisplatin on human non-small-cell lung cancer (NSC... περισσότερα »
Trastuzumab-based photoimmunotherapy integrated with viral HER2 transduction inhibits peritoneally disseminated HER2-negative cancer
Peritoneal dissemination is the most frequent metastasis in gastric cancer and is associated with poor prognosis. The lack of particular target antigens in gastric cancer other than human epidermal growth factor receptor 2 (HER2) has hampered the development of treatments for peritoneal dissemination of gastric cancer. We hypothesized that HER2-extracellular domain (HER2-ECD) gene transduction combined with trastuzumab-based photoimmunotherapy (PIT) might provide excellent and selective anti-tumor effects for peritoneal dissemination of gastric cancer. In vitro, adenovirus/HER2-EC... περισσότερα »
British Society for Matrix Biology – Spring 2015 Meeting Report
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Issue Information
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Clinically relevant variants identified in thoracic aortic aneurysm patients by research exome sequencing
Thoracic aortic aneurysm (TAA) is a genetically heterogeneous disease involving subclinical and progressive dilation of the thoracic aorta, which can lead to life-threatening complications such as dissection or rupture. Genetic testing is important for risk stratification and identification of at risk family members, and clinically available genetic testing panels have been expanding rapidly. However, when past testing results are normal, there is little evidence to guide decision-making about the indications and timing to pursue additional clinical genetic testing. Results from r... περισσότερα »
Two cases of Vici syndrome associated with Idiopathic Thrombocytopenic Purpura (ITP) with a review of the literature
Vici syndrome is a rare congenital disorder first described in 1988. To date, 31 cases have been reported in the literature. The characteristic features of this syndrome include: agenesis of the corpus callosum, albinism, cardiomyopathy, variable immunodeficiency, cataracts, and myopathy. We report two Hispanic sisters with genetically confirmed Vici syndrome who both developed Idiopathic Thrombocytopenic Purpura. To our knowledge, this is an immunologic process that has been previously undescribed within the phenotype of Vici syndrome and should be added to the spectrum of varia... περισσότερα »
Safety of anticoagulation in thrombocytopenic patients with hematologic malignancies: A case series
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The incidence of venous thromboembolism is greater among cancer patients than the general patient population, with recurrence rates also much higher in patients with cancer diagnoses. Patients with hematologic malignancies often experience prolonged periods of thrombocytopenia throughout their disease course, making therapeutic anticoagulation a challenge. We describe 13 cases of patients with hematologic malignancies that […]
Pharmacists’ roles in oncology pharmacy services: Results of a global survey
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background Oncology pharmacists are capable of providing medication therapy management (MTM) because of their level of training, practice experiences, and responsibilities. Very little data exist about their current practice, including changing roles in the multidisciplinary team, overall impact, and effects in the education of patients and healthcare professionals. Methods A 70-item survey about oncology pharmacists’ […]
Antineoplastic agents and thrombotic microangiopathy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Thrombotic microangiopathy is an uncommon but reported adverse effect of a variety of antineoplastic drugs, including chemotherapy agents such as mitomycin C and gemcitabine, and newer targeted agents such as the vascular endothelial growth factor inhibitors. We present a review of thrombotic microangiopathy associated with antineoplastic agents and its implications in current cancer therapy. from […]
A lurking threat: transfer of peanut allergy through peripheral blood stem cell transplantation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background There exist several reports of atopy and allergen-specific IgE-mediated hypersensitivity transferred by bone marrow transplantation, and it has been concluded that the transfer of allergic reactivity results from adoptive transfer of IgE-producing donor-derived B- and/or plasma cells. To the best of our knowledge we report the first case of peanut allergy after PBSCT. […]
Margin to tumor thickness ratio – A predictor of local recurrence and survival in oral squamous cell carcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 6 February 2016 Source:Oral Oncology Author(s): Gregor Heiduschka, Sohaib A. Virk, Carsten E. Palme, Sydney Ch’ng, Michael Elliot, Ruta Gupta, Jonathan Clark ObjectivesTo assess whether small oral squamous cell carcinomas (OSCC) require the same margin clearance as large tumors. We evaluated the association between the ratio of the closest margin to […]
Otologic Concerns for Cleft Lip and Palate Patient
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 1 February 2016 Source:Oral and Maxillofacial Surgery Clinics of North America Author(s): Wayne Berryhill Teaser Understanding eustachian tube physiology and anticipating probable eustachian tube dysfunction is an important component of cleft palate management. This article provides a brief summary of the otologic physiology and issues that may be of concern to […]
A lurking threat: transfer of peanut allergy through peripheral blood stem cell transplantation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background There exist several reports of atopy and allergen-specific IgE-mediated hypersensitivity transferred by bone marrow transplantation, and it has been concluded that the transfer of allergic reactivity results from adoptive transfer of IgE-producing donor-derived B- and/or plasma cells. To the best of our knowledge we report the first case of peanut allergy after PBSCT. […]
Margin to tumor thickness ratio – A predictor of local recurrence and survival in oral squamous cell carcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 6 February 2016 Source:Oral Oncology Author(s): Gregor Heiduschka, Sohaib A. Virk, Carsten E. Palme, Sydney Ch’ng, Michael Elliot, Ruta Gupta, Jonathan Clark ObjectivesTo assess whether small oral squamous cell carcinomas (OSCC) require the same margin clearance as large tumors. We evaluated the association between the ratio of the closest margin to […]
Otologic Concerns for Cleft Lip and Palate Patient
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 1 February 2016 Source:Oral and Maxillofacial Surgery Clinics of North America Author(s): Wayne Berryhill Teaser Understanding eustachian tube physiology and anticipating probable eustachian tube dysfunction is an important component of cleft palate management. This article provides a brief summary of the otologic physiology and issues that may be of concern to […]
Comparison of peripheral near-infrared spectroscopy low-frequency oscillations to other denoising methods in resting state functional MRI with ultrahigh temporal resolution
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Purpose Functional MRI (fMRI) blood–oxygen level–dependent (BOLD) signals result not only from neuronal activation, but also from nonneuronal physiological processes. These changes, especially in the low-frequency domain (0.01–0.2 Hz), can significantly confound inferences about neuronal processes. It is crucial to effectively identify these nuisance low-frequency oscillations (LFOs). Method A high temporal resolution (repetition time, ∼0.5 […]
