Occurrence and detection method evaluation of group B streptococcus from prenatal vaginal specimen
Occurrence and detection method evaluation of group B streptococcus from prenatal vaginal specimen in Northwest China: AbstractSensitive and efficient detection of Group B *Streptococcus* (GBS) colonization in pregnant women is essential for prescription of prophylaxis at the time of delivery as GBS is an opportunistic pathogen known to cause infant mortality. In this report, two studies were conducted on the methods of GBS detection in Shaanxi province, China, a region lacking data for GBS detection and occurrence. For Study 1, 100 GBS culture-positive vaginal swabs were collected... περισσότερα »
SGLT1 sugar transporter/sensor is required for post-oral glucose appetition
SGLT1 sugar transporter/sensor is required for post-oral glucose appetition: Recent findings suggest that the intestinal SGLT1 glucose transporter and sensor mediates in part the appetite-stimulation actions of intragastric (IG) glucose and nonmetabolizable a-methyl-D-glucopyranoside (MDG) infusions in mice. Here we investigated the role of SGLT1 in sugar conditioning using SGLT1 knockout (KO) and C57BL/6J wildtype (WT) mice. An initial experiment revealed that both KO and WT mice maintained on a very low carbohydrate diet display normal preferences for saccharin, which was used i...περισσότερα »
The total baroreflex arc is the open-loop system relating carotid sinus pressure (CSP) to arterial pressure (AP)
Nonlinear Identification of the Total Baroreflex Arc: Chronic Hypertension Model: The total baroreflex arc is the open-loop system relating carotid sinus pressure (CSP) to arterial pressure (AP). Its linear dynamic functioning has been shown to be preserved in spontaneously hypertensive rats. However, the system is known to exhibit nonlinear dynamic behaviors. The aim of this study was to establish nonlinear dynamic models of the total arc (and its sub-systems) in hypertensive rats and to compare these models to previously published models for normotensive rats. Hypertensive rats w... περισσότερα »
Media Damage Following Detergent Sclerotherapy
Appears to be Secondary to the Induction of Inflammation and Apoptosis: An Immunohistochemical Study Elucidating Previous Histological Observations via ScienceDirect Publication: European Journal of Vascular and Endovascular Surgery Publication date: Available online 17 January 2016 *Source:*European Journal of Vascular and Endovascular Surgery Author(s): M.S. Whiteley, S.J. Dos Santos, T.J. Fernandez-Hart, C.T.D. Lee, J.M. Li Objective/BackgroundTraditionally, sclerotherapy has been thought to work by the cytotoxic effect of the sclerosant upon the endothelium alone. However, studies... περισσότερα »
Ventilatory and cerebral blood flow response to CO2
Measuring the human ventilatory and cerebral blood flow response to CO2: a technical consideration for the end-tidal-to-arterial gas gradient: Our aim was to quantify the end-tidal-to-arterial gas gradients for O2 (PET -PaO2) and CO2 (Pa-PETCO2) during a CO2 reactivity test to determine their influence on the cerebrovascular (CVR) and ventilatory (HCVR) response in subjects with (PFO+, *n* = 8) and without (PFO–, *n* = 7) a patent foramen ovale (PFO). We hypothesized that *1*) the Pa-PETCO2 would be greater in hypoxia compared with normoxia, *2*) the Pa-PETCO2 would be similar, wher...περισσότερα »
Oxygen tension, H2S, and NO bioavailability
Oxygen tension, H2S, and NO bioavailability: is there an interaction?: Molecular oxygen (O2) is an essential component for survival and development. Variation in O2 levels leads to changes in molecular signaling and ultimately affects the physiological functions of many organisms. Nitric oxide (NO) and hydrogen sulfide (H2S) are two gaseous cellular signaling molecules that play key roles in several physiological functions involved in maintaining vascular homeostasis including vasodilation, anti-inflammation, and vascular growth. Apart from the aforementioned functions, NO and H2S ... περισσότερα »
The cerebral venous system and hypoxia
The cerebral venous system and hypoxia: Most hypobaric hypoxia studies have focused on oxygen delivery and therefore cerebral blood inflow. Few have studied venous outflow. However, the volume of blood entering and leaving the skull (~700 ml/min) is considerably greater than cerebrospinal fluid production (0.35 ml/min) or edema formation rates and slight imbalances of in- and outflow have considerable effects on intracranial pressure. This dynamic phenomenon is not necessarily appreciated in the currently taught static "Monro-Kellie" doctrine, which forms the basis of the "Tight-Fi...περισσότερα »
Ventilator-induced diaphragm dysfunction
Cervical spinal cord injury exacerbates ventilator-induced diaphragm dysfunction: Cervical spinal cord injury (SCI) can dramatically impair diaphragm muscle function and often necessitates mechanical ventilation (MV) to maintain adequate pulmonary gas exchange. MV is a life-saving intervention. However, prolonged MV results in atrophy and impaired function of the diaphragm. Since cervical SCI can also trigger diaphragm atrophy, it may create preconditions that exacerbate ventilator-induced diaphragm dysfunction (VIDD). Currently, no drug therapy or clinical standard of care exists ...περισσότερα »
Cerebral spinal fluid dynamics: effect of hypoxia and implications for high-altitude illness
Cerebral spinal fluid dynamics: effect of hypoxia and implications for high-altitude illness: The pathophysiology of acute mountain sickness and high-altitude cerebral edema, the cerebral forms of high-altitude illness, remain uncertain and controversial. Persistently elevated or pathological fluctuations in intracranial pressure are thought to cause symptoms similar to those reported by individuals suffering cerebral forms of high-altitude illness. This review first focuses on the basic physiology of the craniospinal system, including a detailed discussion of the long-term and dyn... περισσότερα »
Perception of exertional dyspnea
Effect of experimental modulation of mood on perception of exertional dyspnea in healthy subjects: In many diseases across a range of pathologies (e.g., cardiopulmonary, neuromuscular, and cancer), chronic dyspnea, particularly on exertion, is a major debilitating symptom often associated with clinical anxiety/depression. This study aims to explore the interaction between mood state and exertional dyspnea in a healthy population. Following familiarization, 20 healthy subjects (27-54 years old) performed six 5-min treadmill tests on three separate days. On each day subjects viewed ...περισσότερα »
Ventilation strategies during chest compression
Impact of ventilation strategies during chest compression. An experimental study with clinical observations: The optimal ventilation strategy during cardiopulmonary resuscitation (CPR) is unknown. Chest compression (CC) generates circulation, while during decompression, thoracic recoil generates negative pressure and venous return. Continuous flow insufflation of oxygen (CFI) allows noninterrupted CC and generates positive airway pressure (Paw). The main objective of this study was to assess the effects of positive Paw compared with the current recommended ventilation strategy on i... περισσότερα »
Bilateral reach-to-grasp movement asymmetries
Bilateral reach-to-grasp movement asymmetries after human spinal cord injury: Cervical spinal cord injury (SCI) in humans typically damages both sides of the spinal cord, resulting in asymmetric functional impairments in the arms. Despite this well-accepted notion and the growing emphasis on the use of bimanual training strategies, how movement of one arm affects the motion of the contralateral arm after SCI remains unknown. Using kinematics and multichannel electromyographic (EMG) recordings we studied unilateral and bilateral reach-to-grasp movements to a small and a large cylind... περισσότερα »
Synaptic vesicles in auditory hair cells
Calcium-induced calcium release supports recruitment of synaptic vesicles in auditory hair cells: Hair cells from auditory and vestibular systems transmit continuous sound and balance information to the central nervous system through the release of synaptic vesicles at ribbon synapses. The high activity experienced by hair cells requires a unique mechanism to sustain recruitment and replenishment of synaptic vesicles for continuous release. Using pre- and postsynaptic electrophysiological recordings, we explored the potential contribution of calcium-induced calcium release (CICR) i...περισσότερα »
The temporal dynamics of heading perception in the presence of moving objects
The temporal dynamics of heading perception in the presence of moving objects: Many forms of locomotion rely on the ability to accurately perceive one's direction of locomotion (i.e., heading) based on optic flow. Although accurate in rigid environments, heading judgments may be biased when independently moving objects are present. The aim of this study was to systematically investigate the conditions in which moving objects influence heading perception, with a focus on the temporal dynamics and the mechanisms underlying this bias. Subjects viewed stimuli simulating linear self-mo...περισσότερα »
Development of internal models and predictive abilities for visual tracking during childhood
Development of internal models and predictive abilities for visual tracking during childhood: The prediction of the consequences of our own actions through internal models is an essential component of motor control. Previous studies showed improvement of anticipatory behaviors with age for grasping, drawing, and postural control. Since these actions require visual and proprioceptive feedback, these improvements might reflect both the development of internal models and the feedback control. In contrast, visual tracking of a temporarily invisible target gives specific markers of pred...περισσότερα »
Functional morphometry demonstrates extraocular muscle compartmental contraction during vertical gaze changes
Functional morphometry demonstrates extraocular muscle compartmental contraction during vertical gaze changes: Anatomical studies demonstrate selective compartmental innervation of most human extraocular muscles (EOMs), suggesting the potential for differential compartmental control. This was supported by magnetic resonance imaging (MRI) demonstrating differential lateral rectus (LR) compartmental contraction during ocular counterrolling, differential medial rectus (MR) compartmental contraction during asymmetric convergence, and differential LR, inferior rectus (IR), and superior ...περισσότερα »
CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia
CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia: Chronic intermittent hypoxia (CIH) is a hallmark manifestation of sleep apnea. A heightened carotid body activity and the resulting chemosensory reflex mediate increased sympathetic nerve activity by CIH. However, the mechanisms underlying heightened carotid body activity by CIH are not known. An elevation of intracellular calcium ion concentration ([Ca2+]i) in glomus cells, the primary oxygen-sensing cells, is an essential step for carotid body activation ... περισσότερα »
The N400m of reading words that create emotional violations in sentences
Examining the N400m in affectively negative sentences: A magnetoencephalography study: Abstract Magnetoencephalography was used to examine the effect on the N400m of reading words that create emotional violations in sentences. The beginnings of the sentences were affectively negative and were completed with either a negative congruous, positive incongruous, or neutral incongruous adjective (e.g., “My mother was killed and I felt bad/great/normal”). The task conditions were also manipulated to favor semantic over affective processing. Compared to the sentences with the congruous neg... περισσότερα »
Hypohydration affects pain perception
A preliminary study on how hypohydration affects pain perception: Abstract Chronic pain is a prevalent health issue with one in five people suffering from some form of chronic pain, with loss of productivity and medical costs of chronic pain considerable. However, the treatment of pain can be difficult, as pain perception is complex and can be affected by factors other than tissue damage. This study investigated the effect of hypohydration (mild, voluntary dehydration from ∼24 h of limiting fluid intake, mimicking someone drinking less than usual) on a person's pain perception. Sev... περισσότερα »
Tracking local anesthetic effects using a novel perceptual reference approach
Tracking local anesthetic effects using a novel perceptual reference approach: Drug effects of loco-regional anesthetics are commonly measured by unidimensional pain rating scales. These scales require subjects to transform their perceptual correlates of stimulus intensities onto a visual, verbal or numeric construct that uses a unitless cognitive reference frame. The conceptual understanding and execution of this magnitude estimation task may vary among individuals and populations. To circumvent inherent shortcomings of conventional experimental pain scales, this study aimed at u... περισσότερα »
Dynamic taste responses of parabrachial pontine neurons
Dynamic taste responses of parabrachial pontine neurons in awake rats: The parabrachial nuclei of the pons (PbN) receive almost direct input from taste buds on the tongue, and control basic taste-driven behaviors. Thus it is reasonable to hypothesize that PbN neurons might respond to tastes in a manner similar to that of peripheral receptors-i.e., that these responses might be narrow and relatively "dynamics-free." On the other hand, the majority of the input to PbN descends from forebrain regions such as gustatory cortex (GC), which processes tastes with "temporal codes" in which ...περισσότερα »
Selection of Head and Whisker Coordination Strategies During Goal Oriented Active Touch
Selection of Head and Whisker Coordination Strategies During Goal Oriented Active Touch: In the rodent whisker system, a key model for neural processing and behavioral choices during active sensing, whisker motion is increasingly recognized as only part of a broader motor repertoire employed by rodents during active touch. In particular, recent studies suggest whisker and head motions are tightly coordinated. However, conditions governing the selection and temporal organization of such coordinated sensing strategies remain poorly understood. We videographically reconstructed head a... περισσότερα »
Meropenem dosing requirements against Enterobacteriaceae
Meropenem dosing requirements against Enterobacteriaceae in critically ill patients: influence of renal function, geographical area and presence of extended-spectrum β-lactamases: AbstractThe aim of this study was the evaluation of the influence of the susceptibility patterns of *Escherichia coli* and *Klebsiella pneumoniae* isolates, specifically the presence of extended-spectrum β-lactamases and the geographical area (Europe and USA), on the meropenem dosing requirements in critically ill patients with different degrees of renal function by estimation of the probability of pharm... περισσότερα »
Vanishing calcification associated with a spontaneous ventral spinal cerebrospinal fluid leak
Vanishing calcification associated with a spontaneous ventral spinal cerebrospinal fluid leak: Background Some patients with spontaneous intracranial hypotension have a ventral spinal cerebrospinal fluid (CSF) leak and these CSF leaks may be associated with calcified disk herniations. Identifying these calcifications is helpful in directing treatment. We report here the unusual case of a patient with a ventral CSF leak in whom the associated calcification absorbed over a five-month period. Case report A 42-year-old woman developed orthostatic headaches and bilateral abducens nerve... περισσότερα »
Vitamin D and Dental Caries in Children
Vitamin D and Dental Caries in Children: The purpose of this study was to assess the relationship between vitamin D status and dental caries in Canadian school-aged children participating in the Canadian Health Measures Survey (CHMS). The CHMS was a national cross-sectional study involving physical assessments, laboratory analysis, and interviews. Analysis was restricted to data for 1,017 children 6 to 11 y of age. Outcome variables included the presence of caries and overall total caries score (dmft/DMFT index). Levels of 25-hydroxyvitamin D (25(OH)D) were measured from serum samp... περισσότερα »
The Role of Wnt Signaling in Squamous Cell Carcinoma
The Role of Wnt Signaling in Squamous Cell Carcinoma: Aberrant Wnt signaling pathway is a common feature of tumors and also plays important roles in tumor progression and metastasis of many cancer types. Various lines of evidence suggest that genetic defects affect Wnt pathway components, as well as epigenetic mechanisms that modulate the suppressors of Wnt pathway in oral squamous cell carcinoma. Recently, the newly discovered microRNAs are important molecular regulators in gene expression through transcription and translation repression. They play fundamental roles in a wide spec... περισσότερα »
Purified Human Dental Pulp Stem Cells Promote Osteogenic Regeneration
Purified Human Dental Pulp Stem Cells Promote Osteogenic Regeneration: Human dental pulp stem/progenitor cells (hDPSCs) are attractive candidates for regenerative therapy because they can be easily expanded to generate colony-forming unit–fibroblasts (CFU-Fs) on plastic and the large cell numbers required for transplantation. However, isolation based on adherence to plastic inevitably changes the surface marker expression and biological properties of the cells. Consequently, little is currently known about the original phenotypes of tissue precursor cells that give rise to plastic-...περισσότερα »
Painful Pulpitis and Osteitis
Conditional TNF-{alpha} Overexpression in the Tooth and Alveolar Bone Results in Painful Pulpitis and Osteitis: Tumor necrosis factor–α (TNF-α) is a proalgesic cytokine that is commonly expressed following tissue injury. TNF-α expression not only promotes inflammation but can also lead to pain hypersensitivity in nociceptors. With the established link between TNF-α and inflammatory pain, we identified its increased expression in the teeth of patients affected with caries and pulpitis. We generated a transgenic mouse model (TNF-αglo) that could be used to conditionally overexpress T... περισσότερα »
Roles of Proton-Sensing Receptors in the Transition from Acute to Chronic Pain
Roles of Proton-Sensing Receptors in the Transition from Acute to Chronic Pain: Chronic pain, when not effectively treated, is a leading health and socioeconomic problem and has a harmful effect on all aspects of health-related quality of life. Therefore, understanding the molecular mechanism of how pain transitions from the acute to chronic phase is essential for developing effective novel analgesics. Accumulated evidence has shown that the transition from acute to chronic pain is determined by a cellular signaling switch called hyperalgesic priming, which occurs in primary nocic... περισσότερα »
Diet-Induced Obesity and Its Differential Impact on Periodontal Bone Loss
Diet-Induced Obesity and Its Differential Impact on Periodontal Bone Loss: Obesity is associated with abnormal lipid metabolism and impaired bone homeostasis. The aim of our study was to investigate the impact of specific elevated fatty acid (FA) levels on alveolar bone loss in a *Porphyromonas gingivalis*–induced model of periodontal disease and to analyze underlying cellular mechanisms in bone-resorbing osteoclasts and bone-forming osteoblasts in mice. Four-week-old male C57BL/6 mice were randomly divided in groups and subjected to a palmitic acid (PA)– or oleic acid (OA)–enriche...περισσότερα »
Perception of stochastic envelopes
by normal-hearing and cochlear-implant listeners Publication date: March 2016 *Source:*Hearing Research, Volume 333 Author(s): Philip A. Gomersall, Richard E. Turner, David M. Baguley, John M. Deeks, Hedwig E. Gockel, Robert P. Carlyon We assessed auditory sensitivity to three classes of temporal-envelope statistics (modulation depth, modulation rate, and comodulation) that are important for the perception of ‘sound textures’. The textures were generated by a probabilistic model that prescribes the temporal statistics of a selected number of modulation envelopes, superimposed onto n... περισσότερα »
Influence of the paraflocculus on normal and abnormal spontaneous firing rates in the inferior colliculus
Influence of the paraflocculus on normal and abnormal spontaneous firing rates in the inferior colliculus Publication date: March 2016 *Source:*Hearing Research, Volume 333 Author(s): Darryl P. Vogler, Donald Robertson, Wilhelmina H.A.M. Mulders Spontaneous firing rates of neurons in the central auditory pathway, such as in the inferior colliculus, are known to be increased after cochlear trauma. This so-called hyperactivity is thought to be involved in the generation of tinnitus, a phantom auditory perception. Recent research in an animal model suggests behavioural signs of tinnitus... περισσότερα »
Comparison of group B streptococci colonization in vaginal and rectal specimens by culture method and polymerase chain reaction technique
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 16 δευτερόλεπτα
Streptococcus agalactiae (group B streptococci, GBS) is a colonizing microorganism in pregnant women and without causing symptoms. Colonization of GBS in the rectovaginal region in late of pregnancy is a risk factor for newborn diseases. GBS infection in newborn babies is acquired by the aspiration of infected amniotic fluid or vertical transmission during delivery through […]
Vanishing calcification associated with a spontaneous ventral spinal cerebrospinal fluid leak
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 16 δευτερόλεπτα
Background Some patients with spontaneous intracranial hypotension have a ventral spinal cerebrospinal fluid (CSF) leak and these CSF leaks may be associated with calcified disk herniations. Identifying these calcifications is helpful in directing treatment. We report here the unusual case of a patient with a ventral CSF leak in whom the associated calcification absorbed over […]
The pacemaker-twiddler’s syndrome: an infrequent cause of pacemaker failure
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 16 δευτερόλεπτα
The pacemaker-twiddler’s syndrome is an uncommon cause of pacemaker malfunction. It occurs due to unintentional or deliberate manipulation of the pacemaker pulse generator within its skin pocket by the patient… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Pj0bD9 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Packing and Problematic Feeding Behaviors in CHARGE Syndrome: A Qualitative Analysis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 16 δευτερόλεπτα
To understand packing and problematic feeding behaviors during mealtime in individuals with CHARGE syndrome. Packing, or holding food in one’s cheeks without swallowing, is an adverse feeding behavior that has been described in children with autism and Down syndrome, and in those transitioning from tube to oral feeding. It has never been described in detail […]
SRPT’s Anxious Wait To Continue, ZFGN Has Reason To Flaunt, OGXI Disappoints – RTT News
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 16 δευτερόλεπτα
SRPT’s Anxious Wait To Continue, ZFGN Has Reason To Flaunt, OGXI Disappoints RTT News Chronic rhinosinusitis is a serious, often debilitating infection and inflammation of the nose and sinuses lasting 12 weeks or more. AmpliPhi expects to complete … Shares of OncoGenex Pharmaceuticals Inc. (OGXI) were down over 32% in extended trading … from #ORL-AlexandrosSfakianakis […]
Editorial
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 16 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/23ftcnp via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Topical pine tar: History, properties and use as a treatment for common skin conditions
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 16 δευτερόλεπτα
Abstract Pine tar is the end product of pine wood carbonisation following distillation using extreme heat. An extensive literature search was conducted back to the 1950s for this review. Pine tar has been used in medicine for more than 2000 years to treat a range of skin conditions because of its soothing and antiseptic properties. […]
Combined use of Malaria Antigen and Antibody Enzyme-Linked Immunosorbent Assay for Blood Screening of Plasmodium vivax in the Republic of Korea
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 16 δευτερόλεπτα
Objective: To evaluate the clinical sensitivity and specificity of the newly developed Genedia malaria antigen enzyme-linked immunosorbent assay (ELISA) test and to evaluate the diagnostic efficiency of combined use of the Genedia malaria antigen and antibody ELISA tests to detect P. vivax in blood samples. Materials and Methods: In all, 1070 samples were analyzed; P. […]
Improving the outcome of kidney transplantation by ameliorating renal ischemia reperfusion injury: lost in translation?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 16 δευτερόλεπτα
Kidney transplantation is the treatment of choice in patients with end stage renal disease. During kidney transplantation ischemia reperfusion injury (IRI) occurs, which is a risk factor for acute kidney injury, delayed graft function and acute and chronic rejection. Kidneys from living donors show a superior short- and long-term graft survival compared with deceased donors. […]
p90 ribosomal S6 kinase: a potential therapeutic target in lung cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 16 δευτερόλεπτα
A global survey of cancer has shown that lung cancer is the most common cause of the new cancer cases and cancer deaths in men worldwide. The mortality from lung cancer is more than the combined mortality from breast, prostate and colorectal cancers. The two major histological types of lung cancer are non-small cell lung […]
Hearing Research
Influence of the paraflocculus on normal and abnormal spontaneous firing rates in the inferior colliculus Publication date: March 2016 *Source:*Hearing Research, Volume 333 Author(s): Darryl P. Vogler, Donald Robertson, Wilhelmina H.A.M. Mulders Spontaneous firing rates of neurons in the central auditory pathway, such as in the inferior colliculus, are known to be increased after cochlear trauma. This so-called hyperactivity is thought to be involved in the generation of tinnitus, a phantom auditory perception. Recent research in an animal model suggests behavioural signs of tinnitus... περισσότερα »
The blood-labyrinth barrier (BLB) in the stria vascularis
Pathophysiology of the cochlear intrastrial fluid-blood barrier (review) via Hearing Research [image: (A) The illustration of a cochlear micro-vessel in cross-section shows the major ...] [image: (A) The super-resolution image shows the high density of strial PCs (labeled ...] [image: PVM/Ms in the stria vascularis interface with capillaries. (A) PVM/Ms in the 3-D ...] [image: Noise exposure activates PVM/Ms. (A) & (B) Confocal images show the morphology ...] [image: (A) The surgical view shows an opened bulla and location of a vessel-window on ...] *Source:*Hearing Research Author(s)...περισσότερα »
Risikogruppen mit einer erblichen Disposition für familiäre (polygene) kolorektale Karzinome
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Zusammenfassung Hintergrund Die Identifikation der genetisch disponierten Patienten und Risikopersonen findet zunehmend Einzug in den klinischen Alltag. Der Erkenntnisgewinn durch die Genotyp-Phänotyp-Korrelationen erfordert eine differenzierte klinische Betreuung und ein regelmäßiges Wissensupdate. Ziel Der Beitrag ist eine konzise Zusammenfassung der aktualisierten klinischen und genetischen Aspekte in der Betreuung von Patienten mit hereditären kolorektalen Prädispositionssyndromen. Material und […]
Bedarf, Kenntnis, Akzeptanz und Nutzung von psychosozialen Angeboten
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Zusammenfassung Hintergrund Das kolorektale Karzinom ist die zweithäufigste Krebserkrankung in Deutschland und geht für viele Betroffene mit psychosozialem Distress einher. Mittlerweile ist die psychosoziale Versorgung von Krebspatienten integraler Bestandteil der onkologischen Behandlung. Trotzdem bleibt es unklar, ob das ambulante Unterstützungsangebot den Bedarf deckt und die betroffenen Patienten erreicht. Ziel Nach einem Überblick über die in […]
The pacemaker-twiddler’s syndrome: an infrequent cause of pacemaker failure
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Abstract Background The pacemaker-twiddler’s syndrome is an uncommon cause of pacemaker malfunction. It occurs due to unintentional or deliberate manipulation of the pacemaker pulse generator within its skin pocket by the patient. This causes coiling of the lead and its dislodgement, resulting in failure of ventricular pacing. More commonly reported among elderly females with impaired […]
Association of MDR1 single-nucleotide polymorphisms and haplotype variants with multiple myeloma in Chinese Jiangsu Han population
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Abstract Multidrug resistance 1 (MDR1) gene encodes P-glycoprotein (P-gp), which acts as an efflux pump and provides cell protection against various substances, and its single-nucleotide polymorphisms (SNPs) are associated with the development of malignant hematologic diseases. The present study aimed at investigating whether the MDR1 SNPs and haplotype variants were correlated with the susceptibility to […]
The inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients among Chinese women, an indication for chemotherapy?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Abstract Patients with Luminal A breast cancer often have favorable prognosis, but some of these patients still have lymph node metastases, it remains unclear what the role of adjuvant chemotherapy is in Luminal A subtype with lymph node metastases. The aim of this study was to find a new method to distinguish which Luminal A […]
Cancer stem cell markers in pediatric sarcomas: Sox2 is associated with tumorigenicity in immunodeficient mice
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Abstract The three most frequent pediatric sarcomas, i.e., Ewing’s sarcoma, osteosarcoma, and rhabdomyosarcoma, were examined in this study: three cell lines derived from three primary tumor samples were analyzed from each of these tumor types. Detailed comparative analysis of the expression of three putative cancer stem cell markers related to sarcomas—ABCG2, CD133, and nestin—was performed […]
National characteristics and predictors of neurologic 30-day readmissions
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Objective: To examine national 30-day readmission rates for patients hospitalized with neurologic disorders. Methods: Using the University HealthSystem Consortium (UHC) database, we identified 554,399 index neurologic admissions from October 2011 through January 2015. We collected information regarding age, race, insurance payer, Medicare severity diagnosis-related group, and severity of illness. We examined readmission by diagnosis and […]
Salbutamol-responsive fetal acetylcholine receptor inactivation syndrome
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Transient neonatal myasthenia gravis (TNMG) is a rare and usually self-limiting condition due to maternal acetylcholine receptor (AChR) antibodies in neonates born to mothers with myasthenia gravis (MG). However, a skeletal myopathy with consistent and recognizable features (fetal acetylcholine receptor inactivation syndrome [FARIS]) was recently reported in some patients.1,2 FARIS occurs in association with clinically […]
Differences in the role of black race and stroke risk factors for first vs recurrent stroke
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Objectives: To assess whether black race and other cerebrovascular risk factors have a differential effect on first vs recurrent stroke events. Methods: Estimate the differences in the magnitude of the association of demographic (age, back race, sex) or stroke risk factors (hypertension, diabetes, cigarette smoking, atrial fibrillation, left ventricular hypertrophy, or heart disease) for first […]
A new test for ocular myasthenia gravis?: OMG!
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
At presentation, more than half of patients with myasthenia gravis (MG) harbor the form of the condition known as ocular MG (OMG), characterized by double vision, ptosis, or both. When ptosis is present, the diagnosis is suggested by the Cogan lid twitch, fatigability of the eyelid with sustained upgaze, and recovery with the icepack test […]
Melanocortin receptors: evolution of ligand selectivity for melanocortin peptides
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
The evolution of the melanocortin receptors is linked to the evolution of ACTH, the MSHs, and their common precursor POMC. The origin of the melanocortin receptors and POMC appears to be grounded in the early radiation of the ancestral protochordates. During the genome duplications that have occurred during the evolution of the chordates, the organization […]
Safety assessment of nicotinamide riboside, a form of vitamin B3
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Nicotinamide riboside (NR) is a naturally occurring form of vitamin B3 present in trace amounts in some foods. Like niacin, it has been shown to be a precursor in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). The safety of Niagen™, a synthetic form of NR, was determined using a bacterial reverse mutagenesis assay (Ames), an […]
Bone Disease in Myeloma: The Claws of CRAB
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
A dynamic approach to use bisphosphonates according to biomarkers of bone metabolism is presented in the Z-MARK study by Raje and colleagues. This is a major step forward toward a rational approach to bisphosphonates usage. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lxQNxj via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader […]
Impacts of person-centred integrated chronic heart failure and palliative home care on pharmacological heart failure treatment: a substudy of a randomised trial
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Objective Patients with chronic heart failure (CHF) may be insufficiently treated pharmacologically. Recently, we presented a person-centred integrated Palliative advanced homecaRE and heart FailurE caRe (PREFER) strategy and compared it with usual care (control). Patients managed according to PREFER had improved health-related quality of life and markedly reduced hospitalisations compared with the control group. We […]
MYD88 L265P mutations, but no other variants, identify a subpopulation of DLBCL patients of activated B-cell origin, extranodal involvement and poor outcome
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Purpose: Mutations in MYD88 are found in different lymphoproliferative disorders associated with particular biological characteristics and clinical impact. The aim of this study was to analyze the incidence of MYD88 mutations and its clinical impact in diffuse large B-cell lymphoma (DLBCL). Experimental Design: The incidence, clinico-biological features and outcome of 213 patients (115M/98F; median age […]
Introducing Contactless Blood Pressure Assessment Using a High Speed Video Camera
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Abstract Recent studies demonstrated that blood pressure (BP) can be estimated using pulse transit time (PTT). For PTT calculation, photoplethysmogram (PPG) is usually used to detect a time lag in pulse wave propagation which is correlated with BP. Until now, PTT and PPG were registered using a set of body-worn sensors. In this study a […]
Efficiency of Clinical Decision Support Systems Improves with Experience
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Abstract Efficiency, or the resources spent while performing a specific task, is widely regarded as one the determinants of usability. In this study, the authors hypothesize that having a group of users perform a similar task over a prolonged period of time will lead to improvements in efficiency of that task. This study was performed […]
Lenvatinib: a potential breakthrough in advanced hepatocellular carcinoma?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lxLTAo via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RUmbor via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PqhBas via IFTTT from #Med […]
Prenatal Vitamin Compounds Available in Brazil Are Not Suitable for Adequate Iodine Supplementation of Pregnant Women
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lxLWw5 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RUmdNb via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PqhBau via IFTTT
The inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients among Chinese women, an indication for chemotherapy?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 23 δευτερόλεπτα
Abstract Patients with Luminal A breast cancer often have favorable prognosis, but some of these patients still have lymph node metastases, it remains unclear what the role of adjuvant chemotherapy is in Luminal A subtype with lymph node metastases. The aim of this study was to find a new method to distinguish which Luminal A […]
Noise and Health
Evaluation of the effects of occupational noise exposure on serum aldosterone and potassium among industrial workers *Sajad Zare, Parvin Nassiri, Mohammad Reza Monazzam, Akram Pourbakht, Kamal Azam, Taghi Golmohammadi* Noise and Health 2016 18(80):1-6 The existing literature indicates that occupational exposure to noise may have adverse effects on workers' health. The aim of this study was to evaluate the possible effects of exposure to different sound pressure levels (SPLs) on serum aldosterone and potassium concentration among Iranian blue collar workers in Golgohar Mining and Ind...περισσότερα »
The Sustained-Exposure Dexamethasone Formulation OTO-104 Offers Effective Protection against Cisplatin-Induced Hearing Loss
The Sustained-Exposure Dexamethasone Formulation OTO-104 Offers Effective Protection against Cisplatin-Induced Hearing Loss: The otoprotective effects of OTO-104 were investigated following both acute and chronic administration of cisplatin. The acute administration of cisplatin to guinea pigs resulted in profound hearing loss (70-80 dB SPL) across all frequencies tested. A single intratympanic injection of 6% OTO-104, but not of lower doses, almost completely protected against cisplatin ototoxicity. In contrast, a dexamethasone solution administered under the same experimental cond...περισσότερα »
Relationship of Routine Inadequate Sleep Duration and Periodontitis in a Nationally Representative Sample
Relationship of Routine Inadequate Sleep Duration and Periodontitis in a Nationally Representative Sample: Purpose. Previous research has indicated the public health impact of inadequate sleep duration on health, potentially through an immune-inflammation mechanism. This mechanism also has a role in periodontitis. The purpose of this study is to determine if there is an association of routine inadequate sleep and periodontitis. Methods. Data from merged National Health and Nutrition Examination Survey years 2009-10 and 2011-12 were the data source for the study. The key outcome was ... περισσότερα »
Survivorship care experiences, information, and support needs of patients with oral and oropharyngeal cancer
Survivorship care experiences, information, and support needs of patients with oral and oropharyngeal cancer: Abstract Background There is little research documenting the posttreatment experiences and needs of oral/oropharyngeal cancer survivors. Methods In this cross-sectional study, 92 patients with oral/oropharyngeal cancer diagnosed between 2 and 5 years prior completed a survey about oral cancer information and support needs. Results About half retrospectively reported that they did not receive a written treatment summary. The desire for more oral cancer information was common; ...περισσότερα »
Targeted therapy the angiogenesis pathway : Nintedanib(BIBF1120) in Thyroid Cancer : In thyroid cancer VEGF receptors (VEGFR-1, VEGFR-2), VEGF itself and receptors of the fibroblast growth factor (FGF) and for the platelet-derived growth factor (PDGF) are often overexpressed
Nintedanib(BIBF1120) in Thyroid Cancer: *Conditions*: Medullary Thyroid Cancer (MTC); Differentiated Thyroid Cancer (DTC) *Interventions*: Drug: Nintedanib; Drug: Placebo *Sponsor*: European Organisation for Research and Treatment of Cancer - EORTC For the treatment of thyroid cancer with the so called targeted therapy the angiogenesis pathway has several potential targets. The Receptors for Vascular endothelial growth factor (VEGF) and especially VEGFR-2 is considered to be crucial for the initiation of the formation as well as the maintenance of tumor vasculature. In ... περισσότερα »
Lancet Blood Sampling for Radioiodine Dosimetry in Thyroid Cancer
Evaluation of Lancet Blood Sampling for Radioiodine Dosimetry in Thyroid Cancer: *Conditions*: Cancer of the Thyroid; Cancer of Thyroid; Thyroid Cancer; Thyroid Carcinoma *Interventions*: Other: Lancet blood sampling; Other: Standard intravenous blood sampling *Sponsor*: Royal Surrey County Hospital NHS Foundation Trust Recently published European guidance recommends the evaluation of the radiation dose to the bone marrow in patients undergoing radioiodine therapy for thyroid cancer. The methods described in these guidelines require serial blood samples to be taken ... περισσότερα »
High Intensity Focused Ultrasound (HIFU) in the Treatment of Benign Thyroid Nodules
A Prospective Evaluation of High Intensity Focused Ultrasound (HIFU) in the Treatment of Benign Thyroid Nodules: *Condition*: Benign Thyroid Nodules *Intervention*: Device: Echopulse *Sponsor*: The University of Hong Kong ArmsAssigned InterventionsExperimental: HIFU treatment To collect the data after HIFU treatment Device: Echopulse Echopulse is a real-time US-guided High-intensity focused ultrasound (HIFU) system, the HIFU session is a noninvasive procedure that involves application of a focused high-energy ultrasound beam for thermal tissue ablation inside the targeted zon... περισσότερα »
Quercetin-Induced Cell Death in Human Papillary Thyroid Cancer (B-CPAP) Cells
Quercetin-Induced Cell Death in Human Papillary Thyroid Cancer (B-CPAP) Cells: In this study, we have investigated the antiproliferative effect of quercetin on human papillary thyroid cancer cells and determined the apoptotic mechanisms underlying its actions. We have used different concentrations of quercetin to induce apoptosis and measured cell viability. Apoptosis and cell cycle analysis was determined by flow cytometry using Annexin V and propidium iodide. Finally, we have measured changes in caspase-3 and cleaved poly(ADP-ribose) polymerase (PARP) protein expression levels as ...περισσότερα »
PLGA nanoparticle delivery system for 5-fluorouracil and curcumin on squamous cell carcinoma
Comparative evaluation of Publication date: April 2016 *Source:*Archives of Oral Biology, Volume 64 Author(s): Shaimaa M. Masloub, Mohamed H. Elmalahy, Dina Sabry, Wael S. Mohamed, Sahar H. Ahmed Purpose The purpose of this study is to assess the effect of 5-fluorouracil nanoparticles and curcumin naoparticles on cell proliferation and the expression of the apoptotic marker (caspase 3) in squamous cell carcinoma cell line. Material and methods PLGA 5-fluorouracil nanopartciles and PLGA curcumin nanoparticles were prepared and applied for 24 and 48h on human laryngeal squamous carci...περισσότερα »
Archives of Oral Biology
Comparative evaluation of PLGA nanoparticle delivery system for 5-fluorouracil and curcumin on squamous cell carcinoma Publication date: April 2016 *Source:*Archives of Oral Biology, Volume 64 Author(s): Shaimaa M. Masloub, Mohamed H. Elmalahy, Dina Sabry, Wael S. Mohamed, Sahar H. Ahmed Purpose The purpose of this study is to assess the effect of 5-fluorouracil nanoparticles and curcumin naoparticles on cell proliferation and the expression of the apoptotic marker (caspase 3) in squamous cell carcinoma cell line. Material and methods PLGA 5-fluorouracil nanopartciles and PLGA curcu... περισσότερα »
Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma
in a Northeastern Brazilian population: A pilot study Publication date: April 2016 *Source:*Archives of Oral Biology, Volume 64 Author(s): Joabe dos Santos Pereira, Fabrícia Lima Fontes, Silvia Regina Batistuzzo de Medeiros, Roseana de Almeida Freitas, Lélia Batista de Souza, Márcia Cristina da Costa Miguel Objective to evaluate the association between XPD and XRCC3 polymorphisms and oral squamous cell carcinoma (OSCC). Design the sample consisted of 54 cases of OSCC and 40 cases of inflammatory fibrous hyperplasia (IFH). Genotypes were determined by the polymerase chain reaction-r...περισσότερα »
Goniothalamin induces cell cycle arrest and apoptosis in H400 human oral squamous cell carcinoma
: A caspase-dependent mitochondrial-mediated pathway with downregulation of NF-κβ Publication date: April 2016 *Source:*Archives of Oral Biology, Volume 64 Author(s): Lim K. Li, Ali-Saeed Rola, Fahme A. Kaid, Abdul Manaf Ali, Aied M. Alabsi Goniothalamin is a natural occurring styryl-lactone compound isolated from Goniothalamus macrophyllus. It had been demonstrated to process promising anticancer activity on various cancer cell lines. However, little study has been carried out on oral cancer. The aim of this study was to determine the cytotoxic effects of goniothalamin against H400...περισσότερα »
Maxillary sinus floor augmentation and dental implant placement
using dentin matrix protein-1 gene-modified bone marrow stromal cells mixed with deproteinized boving bone: A comparative study in beagles via Oral Biology Publication date: Available online 19 January 2016 *Source:*Archives of Oral Biology Author(s): Xin Liu, Qiong Li, Fang Wang, Zuolin Wang ObjectiveThe aim of the study was to evaluate the effects of the combined use of dentin matrix protein-1 (DMP1) gene-modified bone marrow stromal cells (BMSCs) and Bio-Oss® for maxillary sinus floor augmentation (MSFA) implant placement in dogs.Materials and methodsBMSCs were derived from bone ma... περισσότερα »
Facial Nerve Schwannoma of Parotid Gland: Difficulties in Diagnosis and Management
Facial Nerve Schwannoma of Parotid Gland: Difficulties in Diagnosis and Management: Facial nerve schwannomas (FNS) are encapsulated benign tumors arising from Schwann cells of seventh cranial nerve. Most of the facial nerve schwannomas are localized in intratemporal region; only 9% of cases involve a portion of the extratemporal segment. Preoperative diagnosis is often unclear; diagnosis is often made intraoperatively. Management of intraparotid FNS is troublesome because of the facial nerve paralysis. In this report we presented a case of intraparotid schwannoma in a 55-year-old ma...περισσότερα »
Adenoid cystic carcinoma of the larynx presenting with unusual subglottic mass: Case report
Adenoid cystic carcinoma of the larynx presenting with unusual subglottic mass: Case report: A 33-year-old woman presented with an unusual subglottic bulging mass accompanied by prolonged cough and wheeze. Laryngeal endoscopy revealed a bilateral, symmetrical mass immediately below the vocal cords with marked airway obstruction. Chronic subglottic laryngitis with inflammation or another condition such as amyloidosis was initially suspected. Cervicothoracic computed tomography revealed an obvious reduction of laryngeal caliber caused by an engulfing mass extending from just under the... περισσότερα »
Coloboma of the eye, heart defects, atresia of the nasal choanae, retardation of growth and/or development, genital and/or urinary abnormalities, and ear abnormalities and deafness.
Packing and Problematic Feeding Behaviors in CHARGE Syndrome: A Qualitative Analysis: To understand packing and problematic feeding behaviors during mealtime in individuals with CHARGE syndrome. Packing, or holding food in one's cheeks without swallowing, is an adverse feeding behavior that has been described in children with autism and Down syndrome, and in those transitioning from tube to oral feeding. It has never been described in detail in CHARGE syndrome, a genetic disorder with a high prevalence of feeding difficulties, tube feeding, and otorhinolaryngological issues. CH... περισσότερα »
Prenatal Vitamin Compounds for Adequate Iodine Supplementation of Pregnant Women
Prenatal Vitamin Compounds Available in Brazil Are Not Suitable for Adequate Iodine Supplementation of Pregnant Women: Thyroid , Vol. 0, No. 0. - Full Text HTML - Full Text PDF (37.7 KB) - Full Text PDF with Links (42.1 KB) Author information Danilo Villagelin,1,2 João Hamilton Romaldini,1 Ana Paula Comarella,2 Giovana De Gobbi Azevedo,1Sarah Cozar Zolio,1 Douglas Bernal Tiago,3 and Laura Sterian Ward2 1Department of Endocrinology and Metabolism, Pontifical University Catholic of Campinas, Campinas, Brazil. 2Laboratory of Cancer Molecular Genetics (GEMOCA), University ... περισσότερα »
Prenatal Vitamin Compounds for Adequate Iodine Supplementation of Pregnant Women
Prenatal Vitamin Compounds Available in Brazil Are Not Suitable for Adequate Iodine Supplementation of Pregnant Women: Thyroid , Vol. 0, No. 0. Full Text HTML Full Text PDF (37.7 KB) Full Text PDF with Links (42.1 KB) Author information Danilo Villagelin,1,2 João Hamilton Romaldini,1 Ana Paula Comarella,2 Giovana De Gobbi Azevedo,1Sarah Cozar Zolio,1 Douglas Bernal… Continue reading Prenatal Vitamin Compounds for Adequate Iodine Supplementation of Pregnant Women
The inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients among Chinese women, an indication for chemotherapy?
Abstract Patients with Luminal A breast cancer often have favorable prognosis, but some of these patients still have lymph node metastases, it remains unclear what the role of adjuvant chemotherapy is in Luminal A subtype with lymph node metastases. The aim of this study was to find a new method to distinguish which Luminal A… Continue reading The inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients among Chinese women, an indication for chemotherapy?
Prenatal Vitamin Compounds Available in Brazil Are Not Suitable for Adequate Iodine Supplementation of Pregnant Women
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lxLWw5 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RUmdNb via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PqhBau via IFTTT from… Continue reading Prenatal Vitamin Compounds Available in Brazil Are Not Suitable for Adequate Iodine Sup... περισσότερα »
Stress in the City: Influence of Urban Social Stress and Violence on Pregnancy and Postpartum Quality of Life among Adolescent and Young Mothers
Abstract Adolescent and young mothers transitioning from pregnancy to postpartum need to maintain an optimal quality of life. Stress and exposure to violence (e.g., intimate partner violence (IPV), nonpartner violence) are predictors of poor quality of life for adult women; however, these associations remain understudied among adolescent and young mothers in urban areas. Guided by… Continue reading Stress in the City: Influence of Urban Social Stress and Violence on Pregnancy and Postpartum Quality of Life among Adolescent and Young Mothers
Transcriptional and epigenetic regulation of POMC gene expression
Expression of the POMC gene integrates numerous inputs that reflect the developmental history of POMC-expressing cells of the pituitary and hypothalamus, as well as their critical role in the endocrine system. These inputs are integrated at specific regulatory sequences within the promoter and pituitary or hypothalamic enhancers of the POMC locus. Investigations of developmental mechanisms… Continue reading Transcriptional and epigenetic regulation of POMC gene expression
Sildenafil prevents renal dysfunction in contrast media-induced nephropathy in Wistar rats
Contrast-induced nephropathy (CIN) is an iatrogenic medical event in stable cardiology patients that may lead to acute renal failure. There is no current successful therapy to manage CIN. Increasing evidence in experimental models and humans has suggested that this disease is associated with renal tubular and vascular injury triggered by oxidative stress. Considering the importance… Continue reading Sildenafil prevents renal dysfunction in contrast media-induced nephropathy in Wistar rats
Melanocortin receptors: evolution of ligand selectivity for melanocortin peptides
The evolution of the melanocortin receptors is linked to the evolution of ACTH, the MSHs, and their common precursor POMC. The origin of the melanocortin receptors and POMC appears to be grounded in the early radiation of the ancestral protochordates. During the genome duplications that have occurred during the evolution of the chordates, the organization… Continue reading Melanocortin receptors: evolution of ligand selectivity for melanocortin peptides
Cancer stem cell markers in pediatric sarcomas: Sox2 is associated with tumorigenicity in immunodeficient mice
Abstract The three most frequent pediatric sarcomas, i.e., Ewing’s sarcoma, osteosarcoma, and rhabdomyosarcoma, were examined in this study: three cell lines derived from three primary tumor samples were analyzed from each of these tumor types. Detailed comparative analysis of the expression of three putative cancer stem cell markers related to sarcomas—ABCG2, CD133, and nestin—was performed… Continue reading Cancer stem cell markers in pediatric sarcomas: Sox2 is associated with tumorigenicity in immunodeficient mice
Safety assessment of nicotinamide riboside, a form of vitamin B3
Nicotinamide riboside (NR) is a naturally occurring form of vitamin B3 present in trace amounts in some foods. Like niacin, it has been shown to be a precursor in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). The safety of Niagen™, a synthetic form of NR, was determined using a bacterial reverse mutagenesis assay (Ames), an… Continue reading Safety assessment of nicotinamide riboside, a form of vitamin B3
Impacts of person-centred integrated chronic heart failure and palliative home care on pharmacological heart failure treatment: a substudy of a randomised trial
Objective Patients with chronic heart failure (CHF) may be insufficiently treated pharmacologically. Recently, we presented a person-centred integrated Palliative advanced homecaRE and heart FailurE caRe (PREFER) strategy and compared it with usual care (control). Patients managed according to PREFER had improved health-related quality of life and markedly reduced hospitalisations compared with the control group. We… Continue reading Impacts of person-centred integrated chronic heart failure and palliative home care on pharmacological heart failure treatment: a substudy of a randomi... περισσότερα »
Loss of ezrin in human intrahepatic cholangiocarcinoma is associated with ectopic expression of E-cadherin
[image: cover.gif?v=1&s=8da50c92b06d5da1183f2623] Abstract Aims Ezrin connects proteins from the plasma membrane to the subcortical cytoskeleton, and contributes to the epithelia integrity by interacting with the cell-cell adhesion molecule E-cadherin. In liver, ezrin is restricted to cholangiocytes where it regulates biliary secretory functions. During carcinogenesis, ezrin expression is impaired and associated with enhancement of cell migratory activity in cancer cells; thereby we aimed to analyze ezrin in cholangiocarcinogenesis. Methods and results Ezrin expression was eval...περισσότερα »
Immunohistochemical Expression of Ki67 and p53 in Wilms Tumor and Its Relationship with Tumor Histology and Stage at Presentation
Aim. Evaluate tumor proliferation marker (Ki67) and p53 tumor suppressor marker in Wilms tumor and correlate with histology, anaplasia, and staging. Design. Prospective, hospital based study conducted at a tertiary pediatric referral centre in south India. Setting. Wilms tumor is the most common childhood renal malignancy worldwide. Anaplasia on histology is associated with treatment resistance but not with aggressiveness clinical presentation. Chemotherapy for Wilms tumor is based on histology and staging. Most patients respond to current chemotherapy protocol. However, a small f... περισσότερα »
Distress, delay of gratification and preference for palliative care in men with prostate cancer
Abstract Background Patient-centered cancer care standards include routine psychosocial distress screening and referral for supportive care services. Although many cancer patients report psychosocial distress that could be alleviated by supportive services including palliative care, patients often decline such services for reasons that are poorly understood. Research on decision-making suggests that during periods of acute distress, individuals have more difficulty prioritizing long-term over immediate gains. Thus, distressed cancer patients may prioritize immediate gains (e.g., a... περισσότερα »
Incidence and outcome of osteonecrosis in children and adolescents after intensive therapy for acute lymphoblastic leukemia (ALL)
Abstract Osteonecrosis (ON), a significant complication following treatment of acute lymphoblastic leukemia (ALL), has a profound impact on quality of life of ALL survivors. We studied incidence and outcome of ON in patients treated on or according to Australian and New Zealand Children's Haematology/ Oncology Group (ANZCHOG) study 8 at The Children's Hospital at Westmead. The study involved retrospective chart review of the patients. ON was defined by development of symptoms and confirmed by magnetic resonance imaging. From 2002–2011, 251 patients (143M, 108F, 59 Standard Risk (SR... περισσότερα »
Advanced Small Animal Conformal Radiation Therapy Device
We have developed a small animal conformal radiation therapy device that provides a degree of geometrical/anatomical targeting comparable to what is achievable in a commercial animal irradiator. small animal conformal radiation therapy device is capable of producing precise and accurate conformal delivery of radiation to target as well as for imaging small animals. The small animal conformal radiation therapy device uses an X-ray tube, a robotic animal position system, and a digital imager. The system is in a steel enclosure with adequate lead shielding following National Council ... περισσότερα »
Development of Splice Variant-Specific Monoclonal Antibodies Against Human α3 Integrin
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy , Vol. 0, No. 0. from Pharmacology via ola Kala on Inoreader http://ift.tt/1lxJ5TT via IFTTT
Systematic review with meta-analysis: diagnostic accuracy of transient elastography for staging of fibrosis in people with alcoholic liver disease
Summary Background The progression of hepatic fibrosis into cirrhosis is a main prognostic factor for survival in people with alcoholic liver disease. The range of cut-off values characterising the stage of hepatic fibrosis seems to be dependent on the aetiology of the liver disease. Aims To determine the diagnostic accuracy of transient elastography (the index test) for diagnosis of fibrosis in alcoholic liver disease when compared with liver biopsy (the reference standard), using the METAVIR scoring system. To establish the optimal cut-off values for the hepatic fibrosis stage... περισσότερα »
EUS guided Pancreatic Drainage for Recurrent Pancreatitis
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Endoscopic sphincterotomy using an isolated-tip needle knife papillotome for a patient with Billroth-II gastrectomy
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Endoscopic Treatment of a Refractory Intrahepatic Bile Leak by Transpapillary Placement of Coils into a Peripheral Bile Duct
from Endocrinology via ola Kala on Inoreader http://ift.tt/1RAL1t9 via IFTTT
Tolerance of a high-protein baked-egg product in egg-allergic children
Publication date: Available online 20 January 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Maryam Saifi, Nithya Swamy, Maria Crain, L. Steven Brown, John Andrew Bird BackgroundEgg allergy is one of the most common immunoglobulin E (IgE)–mediated food allergies. Extensively heating egg has been found to decrease its allergenicity and 55% to 84% of children allergic to egg have been found to tolerate baked-egg products. Because there is no reliable method for predicting baked-egg tolerance, oral food challenges remain the gold standard. Prior studies have reported o... περισσότερα »
The pacemaker-twiddler’s syndrome: an infrequent cause of pacemaker failure
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Abstract Background The pacemaker-twiddler’s syndrome is an uncommon cause of pacemaker malfunction. It occurs due to unintentional or deliberate manipulation of the pacemaker pulse generator within its skin pocket by the patient. This causes coiling of the lead and its dislodgement, resulting in failure of ventricular pacing. More commonly reported among elderly females with impaired […]
Association of MDR1 single-nucleotide polymorphisms and haplotype variants with multiple myeloma in Chinese Jiangsu Han population
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Abstract Multidrug resistance 1 (MDR1) gene encodes P-glycoprotein (P-gp), which acts as an efflux pump and provides cell protection against various substances, and its single-nucleotide polymorphisms (SNPs) are associated with the development of malignant hematologic diseases. The present study aimed at investigating whether the MDR1 SNPs and haplotype variants were correlated with the susceptibility to […]
Eribulin in pretreated metastatic breast cancer patients: results of the TROTTER trial—a multicenter retros pective study of eribulin in real life
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
This retrospective multicenter analysis was aimed to evaluate clinical activity and tolerability of eribulin in pretreated metastatic breast cancer patients in clinical practice. Patients treated with eribulin from January 2012 to July 2013 were enrolled in the observational study from 10 italian hospitals. Tumor and toxicity evaluation were performed according to Agenzia Italiana Farmaco. One-hundred […]
The inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients among Chinese women, an indication for chemotherapy?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Abstract Patients with Luminal A breast cancer often have favorable prognosis, but some of these patients still have lymph node metastases, it remains unclear what the role of adjuvant chemotherapy is in Luminal A subtype with lymph node metastases. The aim of this study was to find a new method to distinguish which Luminal A […]
Prenatal Vitamin Compounds Available in Brazil Are Not Suitable for Adequate Iodine Supplementation of Pregnant Women
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lxLWw5 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RUmdNb via IFTTT
Cancer stem cell markers in pediatric sarcomas: Sox2 is associated with tumorigenicity in immunodeficient mice
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Abstract The three most frequent pediatric sarcomas, i.e., Ewing’s sarcoma, osteosarcoma, and rhabdomyosarcoma, were examined in this study: three cell lines derived from three primary tumor samples were analyzed from each of these tumor types. Detailed comparative analysis of the expression of three putative cancer stem cell markers related to sarcomas—ABCG2, CD133, and nestin—was performed […]
Impacts of person-centred integrated chronic heart failure and palliative home care on pharmacological heart failure treatment: a substudy of a randomised trial
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Objective Patients with chronic heart failure (CHF) may be insufficiently treated pharmacologically. Recently, we presented a person-centred integrated Palliative advanced homecaRE and heart FailurE caRe (PREFER) strategy and compared it with usual care (control). Patients managed according to PREFER had improved health-related quality of life and markedly reduced hospitalisations compared with the control group. We […]
Stress in the City: Influence of Urban Social Stress and Violence on Pregnancy and Postpartum Quality of Life among Adolescent and Young Mothers
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Abstract Adolescent and young mothers transitioning from pregnancy to postpartum need to maintain an optimal quality of life. Stress and exposure to violence (e.g., intimate partner violence (IPV), nonpartner violence) are predictors of poor quality of life for adult women; however, these associations remain understudied among adolescent and young mothers in urban areas. Guided by […]
Melanocortin receptors: evolution of ligand selectivity for melanocortin peptides
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
The evolution of the melanocortin receptors is linked to the evolution of ACTH, the MSHs, and their common precursor POMC. The origin of the melanocortin receptors and POMC appears to be grounded in the early radiation of the ancestral protochordates. During the genome duplications that have occurred during the evolution of the chordates, the organization […]
Vaccination, children’s
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Vaccination, children’s: Vaccinations given to children. In the US, it is currently recommended that all children receive vaccination against the following unless the child has special circumstances, such as a compromised immune system or a neurological disorder: Diphtheria, tetanus, and pertussis (whooping cough), as separate vaccinations or in combination as DPTHaemophilus influenzae type B (HIB)Hepatitis […]
The ideal male jaw angle – an Internet survey
The ideal male jaw angle has not been established. With the advent of additive manufacturing, precise customized shaping is a reality. This study aimed to define the ideal masculine mandibular angle as an aid for 3-dimensional (3D) design. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1RAJmDD via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Isolated bony syngnathia
Isolated bony syngnathia in adults is extremely rare. In 1990, Goodacre and Wallace reported a patient with bilateral fusion of the posterior alveolar arches associated with a dislocation of the right temporomandibular joint, who presented at the age of 39.1 In 2009, Naikmasur et al reported a patient with congenital syngnathia, who presented at the age of 60, with associated bilateral right ankylosis of the temporomandibular joint.2 A 74-year-old reported with isolated unilateral bony fusion of the left alveolar ridges of the maxilla and mandibula in 2012. from #ΓναθοΧειρουργική ... περισσότερα »
Transcriptional and epigenetic regulation of POMC gene expression
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Expression of the POMC gene integrates numerous inputs that reflect the developmental history of POMC-expressing cells of the pituitary and hypothalamus, as well as their critical role in the endocrine system. These inputs are integrated at specific regulatory sequences within the promoter and pituitary or hypothalamic enhancers of the POMC locus. Investigations of developmental mechanisms […]
Lenvatinib: a potential breakthrough in advanced hepatocellular carcinoma?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lxLTAo via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Essential Roles of TIM-1 and TIM-4 Homologs in Adaptive Humoral Immunity in a Zebrafish Model IMMUNOGENETICS
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
TIM-1 and TIM-4 proteins have become increasingly attractive for their critical functions in immune modulation, particularly in CD4+ Th2 cell activation. Thus, these proteins were hypothesized to regulate adaptive humoral immunity. However, further evidence is needed to validate this hypothesis. This study describes the molecular and functional characteristics of TIM-1 and TIM-4 homologs from a […]
Squamous Cell Carcinoma Related Oncogene (SCCRO) Family Members Regulate Cell Growth and Proliferation through Their Cooperative and Antagonistic Effects on Cullin Neddylation Cell Biology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
SCCRO (squamous cell carcinoma related oncogene; a.k.a. DCUN1D1) is a highly conserved gene that functions as an E3 in neddylation. Although inactivation of SCCRO in yeast results in lethality, SCCRO-/- mice are viable. The exclusive presence of highly conserved paralogues in higher organisms led us to assess whether compensation by SCCRO’s paralogues rescues lethality in […]
AP-1 is a key regulator of proinflammatory cytokine TNF{alpha}-mediated triple-negative breast cancer progression Molecular Bases of Disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Triple-negative breast cancer (TNBC) represents a highly aggressive form of breast cancer with limited treatment options. Proinflammatory cytokines such as TNFα can facilitate tumor progression and metastasis. However, the mechanistic aspects of inflammation mediated TNBC progression remain unclear. Using ChIP-seq, we demonstrate that the cistrome for the AP-1 transcription factor c-Jun is comprised of 13800 […]
Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1 Signal Transduction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates the small G protein (GTPase) Rac1 to control Rac1-dependent cytoskeletal dynamics, and thus cell morphology. Three mechanisms of P-Rex1 regulation are currently known: (i) binding of the phosphoinositide second messenger PIP3, (ii) binding of the Gβγ subunits of heterotrimeric G proteins, and (iii) phosphorylation of various […]
Growth-Related Metabolism of the Carbon Storage Poly-3-Hydroxybutyrate in Legionella pneumophila Microbiology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Legionella pneumophila (Lp), the causative agent of Legionnaires disease, has a biphasic life cycle with a switch from a replicative to a transmissive phenotype. During the replicative phase, the bacteria grow within host cells in Legionella-containing vacuoles (LCVs). During the transmissive phenotype and the post-exponential (PE) growth phase, the pathogens express virulence factors, become flagellated, […]
MRI of Normal Pressure Hydrocephalus
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Normal Pressure Hydrocephalus (NPH) is a syndrome found in the elderly which is characterized by ventriculomegaly and deep white matter ischemia (DWMI) on MRI and the clinical triad of gait disturbance, dementia and urinary incontinence. NPH has been estimated to account for up to 10% of cases of dementia and is significant because it is […]
Classification of fatty and dense breast parenchyma: comparison of automatic volumetric density measurement and radiologists classification and their inter-observer variation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background Automatically calculated breast density is a promising alternative to subjective BI-RADS density assessment. However, such software needs a cutoff value for density classification. Purpose To determine the volumetric density threshold which classifies fatty and dense breasts with highest accuracy compared to average BI-RADS density assessment, and to analyze radiologists’ inter-observer variation. Material and Methods […]
T1 hyperintensity in the brain after multiple intravenous injections of gadolinium-based contrast agents
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1T77v4m via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Algenpantucel-L immunotherapy in pancreatic adenocarcinoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Immunotherapy Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NlFXko via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QnxPXk via IFTTT
Nanometre-thick single-crystalline nanosheets grown at the water–air interface
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Article The recently discovered phenomena arising from 2D nanomaterials have led to an increased interest in the fabrication of other ultrathin materials from those typically only observed in the bulk. Here, the authors demonstrate the synthesis of micron-sized, single-crystalline ZnO nanosheets via solution based methods. Nature Communications doi: 10.1038/ncomms10444 Authors: Fei Wang, Jung-Hun Seo, Guangfu […]
Cytomegalovirus and immunotherapy: opportunistic pathogen, novel target for cancer and a promising vaccine vector
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Immunotherapy Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NlFVsR via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ZDbxRZ via IFTTT
Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Article PIEZO1 is a mechanosensitive ion channel, but the mechanism of force transduction is unknown. Here Cox and Bae et al. disrupt the cortical cytoskeleton in HEK293 cells to show that PIEZO1 is gated directly by membrane tension. Nature Communications doi: 10.1038/ncomms10366 Authors: Charles D. Cox, Chilman Bae, Lynn Ziegler, Silas Hartley, Vesna Nikolova-Krstevski, Paul […]
Gene therapy approaches against cancer using in vivo and ex vivo gene transfer of interleukin-12
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Immunotherapy Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NlFWx0 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QnxQKS via IFTTT
A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Article Iron is an essential nutrient but, in high concentrations, it is also toxic to cells. Here, Slavic et al . identify an iron transporter in malaria parasites that plays a major role in iron detoxification and is required for the parasite’s normal development. Nature Communications doi: 10.1038/ncomms10403 Authors: Ksenija Slavic, Sanjeev Krishna, Aparajita Lahree, […]
Prenatal Vitamin Compounds Available in Brazil Are Not Suitable for Adequate Iodine Supplementation of Pregnant Women
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QnxvaT via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ZDbxRT via IFTTT
Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Article While ERK signalling can produce switch-like cell behaviour, phosphorylation of ERK increases linearly with extracellular signals. Here, the authors solve this seeming contradiction by showing that nuclear translocation of ERK behaves in a switch-like manner and is controlled by ERK activity. Nature Communications doi: 10.1038/ncomms10485 Authors: Yuki Shindo, Kazunari Iwamoto, Kazunari Mouri, Kayo Hibino, […]
The ideal male jaw angle – an Internet survey
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The ideal male jaw angle has not been established. With the advent of additive manufacturing, precise customized shaping is a reality. This study aimed to define the ideal masculine mandibular angle as an aid for 3-dimensional (3D) design. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1RAJmDD via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel […]
Isolated bony syngnathia
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Isolated bony syngnathia in adults is extremely rare. In 1990, Goodacre and Wallace reported a patient with bilateral fusion of the posterior alveolar arches associated with a dislocation of the right temporomandibular joint, who presented at the age of 39.1 In 2009, Naikmasur et al reported a patient with congenital syngnathia, who presented at the […]
Macrostructural and Microstructural Brain Lesions Relate to Gait Pathology in Children With Cerebral Palsy
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
*Background*. Even though lower-limb motor disorders are core features of spastic cerebral palsy (sCP), the relationship with brain lesions remains unclear. Unraveling the relation between gait pathology, lower-limb function, and brain lesions in sCP is complex for several reasons; wide heterogeneity in brain lesions, ongoing brain maturation, and gait depends on a number of primary motor functions/deficits (eg, muscle strength, spasticity). *Objective*. To use a comprehensive approach combining conventional MRI and diffusion tensor imaging (DTI) in children with sCP above 3 years... περισσότερα »
Validity and reliability of a portable gait analysis system for measuring spatiotemporal gait characteristics: comparison to an instrumented treadmill
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Gait analysis serves as an important tool for clinicians and other health professionals to assess gait patterns related to functional limitations due to neurological or orthopedic conditions. The purpose of th... from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1Ud75I1 via IFTTT
Evaluation of a smartphone human activity recognition application with able-bodied and stroke participants
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Mobile health monitoring using wearable sensors is a growing area of interest. As the world's population ages and locomotor capabilities decrease, the ability to report on a person's mobility activities outsid... from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1Oy4t62 via IFTTT
Chronic Chagas disease: can prophylaxis and therapeutic vaccines crack this ‘hard nut’?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Immunotherapy Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nowK6i via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Adalimumab in pediatric Crohn’s disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Immunotherapy Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nowGU7 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Algenpantucel-L immunotherapy in pancreatic adenocarcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Immunotherapy Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NlFXko via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
