GARP inhibits allergic airway inflammation
GARP inhibits allergic airway inflammation in a humanized mouse model: [image: cover.gif?v=1&s=ff195289b99d5ad4af62a487] Abstract Background Regulatory T cells (Treg) represent a promising target for novel treatment strategies in patients with inflammatory/allergic diseases. A soluble derivate of the Treg surface molecule Glycoprotein A Repetitions Predominant (sGARP) has strong anti-inflammatory and regulatory effects on human cells *in vitro* as well as *in vivo* through *de novo* induction of peripheral Treg. Aim of this study was to investigate the immunomodulatory function ... περισσότερα »
Panimmunoglobulin and IgE-selective extracorporeal immunoadsorption
in patients with severe atopic dermatitis via Allergy and Clinical Immunology Publication date: Available online 15 March 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Kristian Reich, Julia Deinzer, Anne-Kathrin Fiege, Valerie von Gruben, Anna-Lena Sack, Alice Thraen, Peter Weisenseel, Kristine Breuer, Stefan Jäckle, Markus Meier
Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.
*Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.* Chem Senses. 2016 Mar 14; Authors: Lemon CH, Kang Y, Li J Abstract Oral temperature is a component and modifier of taste perception. Both trigeminal (V) and taste-sensitive cells, including those in the nucleus of the solitary tract (NTS), can respond to oral temperature. However, functional associations in thermal sensitivity between V and gustatory neurons are poorly understood. To study this we recorded electrophysiological responses to oral stimulation with cool (9, 15, 25, 32,...περισσότερα »
Still Eating Despite Decreased Olfactory Pleasure-The Influence of Odor Liking and Wanting on Food Intake.
*Still Eating Despite Decreased Olfactory Pleasure-The Influence of Odor Liking and Wanting on Food Intake.* Chem Senses. 2016 Mar 14; Authors: Sailer U, Triscoli C, Croy I Abstract Typically, the subjective pleasantness of an odor decreases after it has been repeatedly smelled. This study investigates how the pleasantness ("liking") and the wish to be further exposed to the same odor ("wanting") are affected by variety on a longer time scale, and how they relate to actual food intake. Twenty-five participants rated a coconut odor presented 120 times for its liking and wanting be... περισσότερα »
The Gut Microbiota and Autoimmune Inflammation
Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation via ScienceDirect Publication: Immunity Publication date: 15 March 2016 *Source:*Immunity, Volume 44, Issue 3 Author(s): Pawan Kumar, Leticia Monin, Patricia Castillo, Waleed Elsegeiny, William Horne, Taylor Eddens, Amit Vikram, Misty Good, Alexi A. Schoenborn, Kyle Bibby, Ronald C. Montelaro, Dennis W. Metzger, Ajay S. Gulati, Jay K. Kolls Interleukin-17 (IL-17) and IL-17 receptor (IL-17R) signaling are essential for regulating mucosal host defense against many in... περισσότερα »
Human papillomavirus type 16 viral load is decreased following a therapeutic vaccination
Human papillomavirus type 16 viral load is decreased following a therapeutic vaccination: AbstractIn the dose-escalation phase of a Phase I clinical trial in which six subjects each were vaccinated with PepCan at the 50, 100, 250, and 500 μg per peptide dose, the 50 μg dose showed the best histological regression rate. Ten additional subjects were vaccinated at this dose in the final dose phase. As with the dose-escalation phase, no dose-limiting toxicities were observed. Overall, the histological regression rates were 50 % at the 50 μg dose (7 of 14) and 100 μg dose (3 of 6), and ... περισσότερα »
Phagocytosis,Phagocyte-Bacteria Interactions
: An Immunobiologic Process via ScienceDirect Publication: Immunity Publication date: 15 March 2016 *Source:*Immunity, Volume 44, Issue 3 Author(s): Siamon Gordon It has been a century since the death of Élie Metchnikoff, who championed the role of phagocytosis in cellular immunity. Whereas others had observed the uptake of particles by cells from simple to complex organisms, he grasped its significance in the host response to injury and infection and established a firm basis for our understanding of inflammation and tissue homeostasis. The past century has brought improved tools of ce...περισσότερα »
Macrophages in Tissue Repair, Regeneration, and Fibrosis
Macrophages in Tissue Repair, Regeneration, and Fibrosis via ScienceDirect Publication: Immunity Publication date: 15 March 2016 *Source:*Immunity, Volume 44, Issue 3 Author(s): Thomas A. Wynn, Kevin M. Vannella Inflammatory monocytes and tissue-resident macrophages are key regulators of tissue repair, regeneration, and fibrosis. After tissue injury, monocytes and macrophages undergo marked phenotypic and functional changes to play critical roles during the initiation, maintenance, and resolution phases of tissue repair. Disturbances in macrophage function can lead to aberrant repair, ... περισσότερα »
Dermoscopy in the assessment of pigmented lesions: NICE guideline NG14, 2015
Dermoscopy in the assessment of pigmented lesions: NICE guideline NG14, 2015: Dermoscopy describes the in vivo microscopic inspection of skin lesions using polarised or non-polarised light. It can make the diagnosis of melanoma 9-15 times more likely than the naked eye alone.1 A meta-analysis of 12 studies and 6535 lesions by the National Institute for Clinical Excellence (NICE) revealed a sensitivity and specificity of 88% for dermoscopy compared to 70% and 82% for clinical examination.2 When converted to a hypothetical group of 1000 lesions, the benign lesions selected for biopsy ...περισσότερα »
A preliminary microarray assay of the miRNA expression signatures in buccal mucosa of oral submucous fibrosis patients
A preliminary microarray assay of the miRNA expression signatures in buccal mucosa of oral submucous fibrosis patients: [image: cover.gif?v=1&s=c8638541e7a834a7f610f28a] Objectives The objectives of this study are threefold: First is to perform a preliminary microarray analysis of miRNA expression profile to filter out differentially expressed miRNA in oral submucous fibrosis, second is to perform a bioinformatics analysis to identify miRNA-specific predicted genes, and third to retrieve those miRNAs from literature and account for the findings of our investigations. Methods Buc... περισσότερα »
Use of photodynamic therapy and chitosan for inactivacion of Candida albicans
Use of photodynamic therapy and chitosan for inactivacion of Candida albicans in a murine model.: [image: cover.gif?v=1&s=c8638541e7a834a7f610f28a] Background The wide use of topical and systemic antifungal agents as the conventional treatment for oral candidiasis has caused *Candida albicans* to develop resistance to these agents. The aims of this study were to evaluate the effects of photodynamic therapy (PDT) and chitosan on buccal candidiasis and study the possible enhancive effect of chitosan on the photosensitizer methylene blue. Methods Thirty-five DBA/2 immunosuppressed ... περισσότερα »
Could the PI3K canonical pathway be a common link between chronic inflammatory conditions and oral carcinogenesis?
Could the PI3K canonical pathway be a common link between chronic inflammatory conditions and oral carcinogenesis?: The association between chronic inflammatory disorders and oral carcinogenesis has been both a source of interest and contention. Based upon its central importance in oral carcinogenesis, the finding that the PI3k/Akt/mTOR pathway is activated in oral lichen planus, chronic graft-versus-host disease, and chronic oral candidiasis suggests that it may provide a link between benign and malignant oral conditions. Here, we discuss a possible mechanistic rationale that addr...περισσότερα »
The management of neuropathic orofacial pain (NOP) : Neuromodulatory medications (NMs), such as amitriptyline, carbamazepine and gabapentin, are used as topical preparations
Effect of topical neuromodulatory medications on oral and skin keratinocytes: [image: cover.gif?v=1&s=c8638541e7a834a7f610f28a] Background Neuromodulatory medications (NMs), such as amitriptyline, carbamazepine and gabapentin, are used as topical preparations for the management of neuropathic orofacial pain (NOP) and have produced promising preliminary results. The aim of this study was to investigate the effects of three aforementioned NMs on cell lines relevant to the orofacial tissues *in vitro* as no published studies have examined the effect of these topical NMs. Methods C... περισσότερα »
Effect of topical neuromodulatory medications on oral and skin keratinocytes
Effect of topical neuromodulatory medications on oral and skin keratinocytes: [image: cover.gif?v=1&s=c8638541e7a834a7f610f28a] Background Neuromodulatory medications (NMs), such as amitriptyline, carbamazepine and gabapentin, are used as topical preparations for the management of neuropathic orofacial pain (NOP) and have produced promising preliminary results. The aim of this study was to investigate the effects of three aforementioned NMs on cell lines relevant to the orofacial tissues *in vitro* as no published studies have examined the effect of these topical NMs. Methods C... περισσότερα »
Zika virus infection spread through saliva – a truth or myth?
Zika virus infection spread through saliva – a truth or myth? via Brazilian Oral Research Abstract In this Point-of-view article we highlighted some features related to saliva and virus infection, in special for zika virus. In addition, we pointed out the potential oral problems caused by a microcephaly originated by a zika virus infection. In the end the, we demonstrated the importance of a more comprehensive exploration of saliva and their components as a fluid for diagnostic and therapeutic approaches on oral and systemic diseases.
Immunoexpression of hoxb7 and hoxb9 in salivary gland tumours
Immunoexpression of hoxb7 and hoxb9 in salivary gland tumours: [image: cover.gif?v=1&s=c8638541e7a834a7f610f28a] Background Salivary gland carcinomas are uncommon neoplasms and the identification of new prognostic indicators could improve their management. HOXB7 and HOXB9 are members of the class I homeobox-containing genes important for normal embryogenesis and that are dysregulated in several human neoplasms. This study investigated HOXB7 and HOXB9 expressions in salivary gland tumourigenesis, their correlation with neoplastic proliferative and angiogenic features and their im...περισσότερα »
PI3K–AKT–mTOR pathway proteins are differently expressed in oral carcinogenesis
PI3K–AKT–mTOR pathway proteins are differently expressed in oral carcinogenesis: [image: cover.gif?v=1&s=c8638541e7a834a7f610f28a] Background PI3K–AKT–mTOR signaling pathway is associated with several cellular functions and is frequently changed in several malignancies. The aim of this study was to characterize the immunohistochemical expression pattern of components in PI3K–AKT–mTOR signaling pathway in oral epithelial dysplasia (OED), comparing to oral squamous cell carcinoma (OSCC) and non-dysplastic oral tissues (NDOT). Methods A total of 186 cases of NDOT, OED and OSCC were...περισσότερα »
Mixed biofilms formed by C. albicans and non-albicans species
: a study of microbial interactions via Brazilian Oral Research Abstract Most Candida infections are related to microbial biofilms often formed by the association of different species. The objective of this study was to evaluate the interactions between Candida albicans and non-albicans species in biofilms formed in vitro. The non-albicans species studied were:Candida tropicalis, Candida glabrata andCandida krusei. Single and mixed biofilms (formed by clinical isolates of C. albicans and non-albicans species) were developed from standardized suspensions of each strain (107 cells/mL),...περισσότερα »
Escherichia colilipopolysaccharide (LPS).Ozone gas (OZY® System) and high frequency electric pulse (Endox® System) systems
LPS levels in root canals after the use of ozone gas and high frequency electrical pulses via Brazilian Oral Research Abstract The present study aims to verify the effect of ozone gas (OZY® System) and high frequency electric pulse (Endox® System) systems on human root canals previously contaminated with Escherichia colilipopolysaccharide (LPS). Fifty single-rooted teeth had their dental crowns removed and root lengths standardized to 16 mm. The root canals were prepared up to #60 hand K-files and sterilized using gamma radiation with cobalt 60. The specimens were divided into the fo... περισσότερα »
Oral health-related quality of life (OHRQoL) questionnaire
Parental influence on children’s answers to an oral-health-related quality of life questionnaire via Brazilian Oral Research Abstract The aim of the study was to evaluate parental influence on children’s answers to an oral health-related quality of life (OHRQoL) questionnaire. A cross-sectional study was conducted with a non-probabilistic sample of 84 pairs of 5-year-olds and parents/guardians. The participants were selected from a primary family healthcare center in Campina Grande, Brazil. First, the children and parents answered respective versions of the Scale of Oral Health Outco... περισσότερα »
Gastroesophageal reflux and congenital gastrointestinal malformations.
[image: http:--http://ift.tt/1YyhL4R] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Gastroesophageal reflux and congenital gastrointestinal malformations.* World J Gastroenterol. 2015 Jul 28;21(28):8508-15 Authors: Marseglia L, Manti S, D'Angelo G, Gitto E, Salpietro C, Centorrino A, Scalfari G, Santoro G, Impellizzeri P, Romeo C Abstract Although the outcome of newborns with surgical congenital diseases (e.g., diaphragmatic hernia; esophageal atresia; omphalocele; gastroschisis) has improved rapidly with recent advances in perinatal intensive care and surgery, infant su... περισσότερα »
Systematic review: Eosinophilic esophagitis in Asian countries.
[image: http:--http://ift.tt/1YyhL4R] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Systematic review: Eosinophilic esophagitis in Asian countries.* World J Gastroenterol. 2015 Jul 21;21(27):8433-40 Authors: Kinoshita Y, Ishimura N, Oshima N, Ishihara S Abstract AIM: To investigate the prevalence and the clinical characteristics of Asian patients with eosinophilic esophagitis. METHODS: We conducted a systematic search of the PubMed and Web of Science databases for original studies, case series, and individual case reports of eosinophilic esophagitis in Asian countries pub... περισσότερα »
The disappointing performance of the new "Magnetic Sphincters": a wrong idea or a wrong realization?
Related Articles *The disappointing performance of the new "Magnetic Sphincters": a wrong idea or a wrong realization?* J Gastrointestin Liver Dis. 2015 Jun;24(2):149-50 Authors: Bortolotti M PMID: 26114172 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/253S0Q8
Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility.
[image: http:--ivyspring.com-images-linkout-ijbs] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility.* Int J Biol Sci. 2015;11(7):794-802 Authors: Chen J, Hou N, Zhang C, Teng Y, Cheng X, Li Z, Ren J, Zeng J, Li R, Wang W, Yang X, Lan Y Abstract As a master component of endosomal sorting complex required for transport proteins, hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) participates multiple cellular behaviors. However, the physiological role of Hgs in smooth muscle cells (SMCs) is by f... περισσότερα »
[Interpretation of ultrasound findings in otorhinolaryngology. Salivary glands, paraganglioma, angioma, esophagus, hypopharynx, extra cranial vessels and temporomandibular joint].
[image: http:--production.springer.de-OnlineReso] Related Articles *[Interpretation of ultrasound findings in otorhinolaryngology. Salivary glands, paraganglioma, angioma, esophagus, hypopharynx, extra cranial vessels and temporomandibular joint].* HNO. 2015 Jun;63(6):453-65; quiz 466-7 Authors: Bozzato A Abstract The second part of this continuing medical education article focuses on sonographic assessment of the salivary glands, cervical paraganglioma, angioma, esophagus, extra cranial blood vessels and the temporomandibular joint. The currently available minimally invasive ther... περισσότερα »
Four-branch Prosthetic Graft Used for Stanford Type A Aortic Dissection with Aberrant Right Subclavian Artery.
[image: http:--http://ift.tt/1Zbeyup] Related Articles *Four-branch Prosthetic Graft Used for Stanford Type A Aortic Dissection with Aberrant Right Subclavian Artery.* Chin Med J (Engl). 2015 Jun 5;128(11):1558 Authors: Ren CW, Lai YQ, Yang S, Xu SD, Sun LZ PMID: 26021518 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/253S0PY
Incidence and Risk Factors of Abdominal Complications After Lung Transplantation.
[image: http:--production.springer.de-OnlineReso] Related Articles *Incidence and Risk Factors of Abdominal Complications After Lung Transplantation.* World J Surg. 2015 Sep;39(9):2274-81 Authors: Grass F, Schäfer M, Cristaudi A, Berutto C, Aubert JD, Gonzalez M, Demartines N, Ris HB, Soccal PM, Krueger T Abstract BACKGROUND: Due to the underlying diseases and the need for immunosuppression, patients after lung transplantation are particularly at risk for gastrointestinal (GI) complications that may negatively influence long-term outcome. The present study assessed the incidences ... περισσότερα »
Acid reflux and head and neck cancer risk: A nationwide registry over 13 years.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Acid reflux and head and neck cancer risk: A nationwide registry over 13 years.* Auris Nasus Larynx. 2015 Oct;42(5):401-5 Authors: Kuo CL, Chen YT, Shiao AS, Lien CF, Wang SJ Abstract OBJECTIVE: Gastro-esophageal reflux disease (GERD) is a highly prevalent disorder; however, important questions remain regarding the link between GERD and extra-esophageal cancers. This nationwide cohort study investigated the risk of developing head and neck cancers (HNCs) among patients with GERD. METHODS: Newly diagnosed GERD pati...περισσότερα »
A typical megaesophagus: interesting imaging for diagnosis.
[image: http:--http://ift.tt/1Zbeyup] Related Articles *A typical megaesophagus: interesting imaging for diagnosis.* Chin Med J (Engl). 2015 May 20;128(10):1418 Authors: Zhu SB, Zhu J, Yan M, Liu Y PMID: 25963368 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/253RZLY
Mortality trend and predictors of mortality in dysphagic stroke patients postpercutaneous endoscopic gastrostomy.
[image: http:--http://ift.tt/1Zbeyup] Related Articles *Mortality trend and predictors of mortality in dysphagic stroke patients postpercutaneous endoscopic gastrostomy.* Chin Med J (Engl). 2015 May 20;128(10):1331-5 Authors: Jiang YL, Ruberu N, Liu XS, Xu YH, Zhang ST, Chan DK Abstract BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) feeding is widely used in stroke patients suffering from persistent dysphagia; however, predicting the risks and benefits of PEG insertion in the individual patient is difficult. The aim of our study was to investigate if candidate risk factors ... περισσότερα »
Arytenoid cartilage chondroma.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Arytenoid cartilage chondroma.* Auris Nasus Larynx. 2015 Oct;42(5):428-30 Authors: Lee DH, Kim JH, Yoon TM, Lee JK, Lim SC Abstract Arytenoid chondroma is an extremely rare benign cartilaginous tumor. We report a case of a patient with arytenoid chondroma initially mimicking laryngopharyngeal reflux. Clinicians should consider the possibility of the arytenoid chondroma in the differential diagnosis of patients with vocal cord palsy, or arytenoid swelling caused by laryngopharyngeal reflux. PMID: 25960446 [PubMed -... περισσότερα »
A Novel Technique of Anti-reflux Esophagogastrostomy Following Left Thoracoabdominal Esophagectomy for Carcinoma of the Esophagogastric Junction.
[image: http:--production.springer.de-OnlineReso] Related Articles *A Novel Technique of Anti-reflux Esophagogastrostomy Following Left Thoracoabdominal Esophagectomy for Carcinoma of the Esophagogastric Junction.* World J Surg. 2015 Sep;39(9):2359-61 Authors: Mine S, Nunobe S, Watanabe M Abstract We developed an anti-reflux technique of intrathoracic esophagogastrostomy, based on the "Kamikawa procedure" or "Double flap technique", which is sometimes used in Japan after open proximal gastrectomy for early upper gastric cancer. We applied this technique to four patients with tumor... περισσότερα »
Experimental pulmonary fibrosis in rats with chronic gastric acid reflux esophagitis.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Experimental pulmonary fibrosis in rats with chronic gastric acid reflux esophagitis.* Auris Nasus Larynx. 2015 Oct;42(5):382-4 Authors: Shimazu R, Aoki S, Kuratomi Y Abstract OBJECTIVE: To elucidate the association between gastric acid reflux and respiratory diseases by studying the histological changes of the lower airway in rats with chronic acid reflux esophagitis. METHODS: An experimental rat model of chronic acid reflux esophagitis was surgically created. The lower airways of these rats were histologically o... περισσότερα »
Outcome for Asymptomatic Recurrence Following Laparoscopic Repair of Very Large Hiatus Hernia.
[image: http:--production.springer.de-OnlineReso] Related Articles *Outcome for Asymptomatic Recurrence Following Laparoscopic Repair of Very Large Hiatus Hernia.* J Gastrointest Surg. 2015 Aug;19(8):1385-90 Authors: Wang Z, Bright T, Irvine T, Thompson SK, Devitt PG, Watson DI Abstract BACKGROUND: Radiological follow-up following repair of large hiatus hernias have identified recurrence rates of 20-30%, although most are small and asymptomatic. Whether patients will eventually develop clinical problems is uncertain. This study evaluated the outcome for individuals identified with ... περισσότερα »
Video Assisted Thoracoscopic Surgical Enucleation of a Giant Esophageal Leiomyoma Presenting with Persistent Cough.
*Video Assisted Thoracoscopic Surgical Enucleation of a Giant Esophageal Leiomyoma Presenting with Persistent Cough.* Case Rep Surg. 2016;2016:7453259 Authors: Mujawar P, Pawar T, Chavan RN Abstract Esophageal leiomyoma is a relatively rare tumor of esophagus but it is the most common benign neoplasm of the esophagus. Small esophageal leiomyoma can be observed but larger ones and those producing symptoms should be excised. As observed for other esophageal tumors, dysphagia is its main symptom. Traditionally, open thoracotomy and enucleation are its main treatment but in the last ... περισσότερα »
[Perioperative Oral Management for Esophageal Cancer Patients].
*[Perioperative Oral Management for Esophageal Cancer Patients].* Kyobu Geka. 2016 Jan;69(1):35-9 Authors: Makino T, Yamasaki M, Fujii N, Tanaka N, Nohara K, Doki Y Abstract Aspiration pneumonia, known as one of the most common postoperative complication after esophagectomy for esophageal cancer, can be critical profoundly affecting upon postoperative course of patients. Since oral bacteria can be one of causes for development of postoperative pneumonia, perioperative oral management has very important role in reducing morbidity and improving function of dysphagia. We started peri... περισσότερα »
Palliative treatment of malignant dysphagia: stent by and await further instructions.
*Palliative treatment of malignant dysphagia: stent by and await further instructions.* Gastrointest Endosc. 2016 Apr;83(4):753-5 Authors: Kappelle WF, Vleggaar FP PMID: 26975282 [PubMed - in process] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1QXcdjb
Gastroesophageal reflux and congenital gastrointestinal malformations.
[image: http:--http://ift.tt/1YyhL4R] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Gastroesophageal reflux and congenital gastrointestinal malformations.* World J Gastroenterol. 2015 Jul 28;21(28):8508-15 Authors: Marseglia L, Manti S, D'Angelo G, Gitto E, Salpietro C, Centorrino A, Scalfari G, Santoro G, Impellizzeri P, Romeo C Abstract Although the outcome of newborns with surgical congenital diseases (e.g., diaphragmatic hernia; esophageal atresia; omphalocele; gastroschisis) has improved rapidly with recent advances in perinatal intensive care and surgery, infant su... περισσότερα »
The disappointing performance of the new "Magnetic Sphincters": a wrong idea or a wrong realization?
Related Articles *The disappointing performance of the new "Magnetic Sphincters": a wrong idea or a wrong realization?* J Gastrointestin Liver Dis. 2015 Jun;24(2):149-50 Authors: Bortolotti M PMID: 26114172 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/253S0Q8
Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility.
[image: http:--ivyspring.com-images-linkout-ijbs] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility.* Int J Biol Sci. 2015;11(7):794-802 Authors: Chen J, Hou N, Zhang C, Teng Y, Cheng X, Li Z, Ren J, Zeng J, Li R, Wang W, Yang X, Lan Y Abstract As a master component of endosomal sorting complex required for transport proteins, hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) participates multiple cellular behaviors. However, the physiological role of Hgs in smooth muscle cells (SMCs) is by f... περισσότερα »
Four-branch Prosthetic Graft Used for Stanford Type A Aortic Dissection with Aberrant Right Subclavian Artery.
[image: http:--http://ift.tt/1Zbeyup] Related Articles *Four-branch Prosthetic Graft Used for Stanford Type A Aortic Dissection with Aberrant Right Subclavian Artery.* Chin Med J (Engl). 2015 Jun 5;128(11):1558 Authors: Ren CW, Lai YQ, Yang S, Xu SD, Sun LZ PMID: 26021518 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/253S0PY
Incidence and Risk Factors of Abdominal Complications After Lung Transplantation.
[image: http:--production.springer.de-OnlineReso] Related Articles *Incidence and Risk Factors of Abdominal Complications After Lung Transplantation.* World J Surg. 2015 Sep;39(9):2274-81 Authors: Grass F, Schäfer M, Cristaudi A, Berutto C, Aubert JD, Gonzalez M, Demartines N, Ris HB, Soccal PM, Krueger T Abstract BACKGROUND: Due to the underlying diseases and the need for immunosuppression, patients after lung transplantation are particularly at risk for gastrointestinal (GI) complications that may negatively influence long-term outcome. The present study assessed the incidences ... περισσότερα »
Acid reflux and head and neck cancer risk: A nationwide registry over 13 years.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Acid reflux and head and neck cancer risk: A nationwide registry over 13 years.* Auris Nasus Larynx. 2015 Oct;42(5):401-5 Authors: Kuo CL, Chen YT, Shiao AS, Lien CF, Wang SJ Abstract OBJECTIVE: Gastro-esophageal reflux disease (GERD) is a highly prevalent disorder; however, important questions remain regarding the link between GERD and extra-esophageal cancers. This nationwide cohort study investigated the risk of developing head and neck cancers (HNCs) among patients with GERD. METHODS: Newly diagnosed GERD pati...περισσότερα »
A typical megaesophagus: interesting imaging for diagnosis.
[image: http:--http://ift.tt/1Zbeyup] Related Articles *A typical megaesophagus: interesting imaging for diagnosis.* Chin Med J (Engl). 2015 May 20;128(10):1418 Authors: Zhu SB, Zhu J, Yan M, Liu Y PMID: 25963368 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/253RZLY
Arytenoid cartilage chondroma.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Arytenoid cartilage chondroma.* Auris Nasus Larynx. 2015 Oct;42(5):428-30 Authors: Lee DH, Kim JH, Yoon TM, Lee JK, Lim SC Abstract Arytenoid chondroma is an extremely rare benign cartilaginous tumor. We report a case of a patient with arytenoid chondroma initially mimicking laryngopharyngeal reflux. Clinicians should consider the possibility of the arytenoid chondroma in the differential diagnosis of patients with vocal cord palsy, or arytenoid swelling caused by laryngopharyngeal reflux. PMID: 25960446 [PubMed -... περισσότερα »
Fractures of the mandibular angle : Single miniplate fixation with MMF,Double miniplate fixation with MMF,Double miniplate fixation without MMF
A comparison of three treatment methods for fractures of the mandibular angle via Oral and Maxillofacial Surgery Publication date: Available online 14 March 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): M.-Y. Kim, C.-H. Kim, S.-J. Han, J.-H. Lee The purpose of this study was to determine a practical and cost-effective treatment method for fixing mandibular angle fractures using miniplates. Patients were divided into three groups for comparison, based on the intraoperative plates and maxillomandibular fixation (MMF) used: group A, single miniplate fixa... περισσότερα »
Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.
*Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.* Chem Senses. 2016 Mar 14; Authors: Lemon CH, Kang Y, Li J Abstract Oral temperature is a component and modifier of taste perception. Both trigeminal (V) and taste-sensitive cells, including those in the nucleus of the solitary tract (NTS), can respond to oral temperature. However, functional associations in thermal sensitivity between V and gustatory neurons are poorly understood. To study this we recorded electrophysiological responses to oral stimulation with cool (9, 15, 25, 32,...περισσότερα »
Still Eating Despite Decreased Olfactory Pleasure-The Influence of Odor Liking and Wanting on Food Intake.
*Still Eating Despite Decreased Olfactory Pleasure-The Influence of Odor Liking and Wanting on Food Intake.* Chem Senses. 2016 Mar 14; Authors: Sailer U, Triscoli C, Croy I Abstract Typically, the subjective pleasantness of an odor decreases after it has been repeatedly smelled. This study investigates how the pleasantness ("liking") and the wish to be further exposed to the same odor ("wanting") are affected by variety on a longer time scale, and how they relate to actual food intake. Twenty-five participants rated a coconut odor presented 120 times for its liking and wanting be... περισσότερα »
Gastroesophageal reflux and congenital gastrointestinal malformations.
[image: http:--http://ift.tt/1YyhL4R] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Gastroesophageal reflux and congenital gastrointestinal malformations.* World J Gastroenterol. 2015 Jul 28;21(28):8508-15 Authors: Marseglia L, Manti S, D'Angelo G, Gitto E, Salpietro C, Centorrino A, Scalfari G, Santoro G, Impellizzeri P, Romeo C Abstract Although the outcome of newborns with surgical congenital diseases (e.g., diaphragmatic hernia; esophageal atresia; omphalocele; gastroschisis) has improved rapidly with recent advances in perinatal intensive care and surgery, infant s... περισσότερα »
Systematic review: Eosinophilic esophagitis in Asian countries.
[image: http:--http://ift.tt/1YyhL4R] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Systematic review: Eosinophilic esophagitis in Asian countries.* World J Gastroenterol. 2015 Jul 21;21(27):8433-40 Authors: Kinoshita Y, Ishimura N, Oshima N, Ishihara S Abstract AIM: To investigate the prevalence and the clinical characteristics of Asian patients with eosinophilic esophagitis. METHODS: We conducted a systematic search of the PubMed and Web of Science databases for original studies, case series, and individual case reports of eosinophilic esophagitis in Asian countries pu... περισσότερα »
The disappointing performance of the new "Magnetic Sphincters": a wrong idea or a wrong realization?
Related Articles *The disappointing performance of the new "Magnetic Sphincters": a wrong idea or a wrong realization?* J Gastrointestin Liver Dis. 2015 Jun;24(2):149-50 Authors: Bortolotti M PMID: 26114172 [PubMed - indexed for MEDLINE] from #ENT via xlomafota13 on Inoreader http://ift.tt/253S0Q8 via IFTTT
Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility.
[image: http:--ivyspring.com-images-linkout-ijbs] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility.* Int J Biol Sci. 2015;11(7):794-802 Authors: Chen J, Hou N, Zhang C, Teng Y, Cheng X, Li Z, Ren J, Zeng J, Li R, Wang W, Yang X, Lan Y Abstract As a master component of endosomal sorting complex required for transport proteins, hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) participates multiple cellular behaviors. However, the physiological role of Hgs in smooth muscle cells (SMCs) is by ... περισσότερα »
[Interpretation of ultrasound findings in otorhinolaryngology. Salivary glands, paraganglioma, angioma, esophagus, hypopharynx, extra cranial vessels and temporomandibular joint].
[image: http:--production.springer.de-OnlineReso] Related Articles *[Interpretation of ultrasound findings in otorhinolaryngology. Salivary glands, paraganglioma, angioma, esophagus, hypopharynx, extra cranial vessels and temporomandibular joint].* HNO. 2015 Jun;63(6):453-65; quiz 466-7 Authors: Bozzato A Abstract The second part of this continuing medical education article focuses on sonographic assessment of the salivary glands, cervical paraganglioma, angioma, esophagus, extra cranial blood vessels and the temporomandibular joint. The currently available minimally invasive the... περισσότερα »
Four-branch Prosthetic Graft Used for Stanford Type A Aortic Dissection with Aberrant Right Subclavian Artery.
[image: http:--http://ift.tt/1Zbeyup] Related Articles *Four-branch Prosthetic Graft Used for Stanford Type A Aortic Dissection with Aberrant Right Subclavian Artery.* Chin Med J (Engl). 2015 Jun 5;128(11):1558 Authors: Ren CW, Lai YQ, Yang S, Xu SD, Sun LZ PMID: 26021518 [PubMed - indexed for MEDLINE] from #ENT via xlomafota13 on Inoreader http://ift.tt/253S0PY via IFTTT
Incidence and Risk Factors of Abdominal Complications After Lung Transplantation.
[image: http:--production.springer.de-OnlineReso] Related Articles *Incidence and Risk Factors of Abdominal Complications After Lung Transplantation.* World J Surg. 2015 Sep;39(9):2274-81 Authors: Grass F, Schäfer M, Cristaudi A, Berutto C, Aubert JD, Gonzalez M, Demartines N, Ris HB, Soccal PM, Krueger T Abstract BACKGROUND: Due to the underlying diseases and the need for immunosuppression, patients after lung transplantation are particularly at risk for gastrointestinal (GI) complications that may negatively influence long-term outcome. The present study assessed the incidences... περισσότερα »
Acid reflux and head and neck cancer risk: A nationwide registry over 13 years.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Acid reflux and head and neck cancer risk: A nationwide registry over 13 years.* Auris Nasus Larynx. 2015 Oct;42(5):401-5 Authors: Kuo CL, Chen YT, Shiao AS, Lien CF, Wang SJ Abstract OBJECTIVE: Gastro-esophageal reflux disease (GERD) is a highly prevalent disorder; however, important questions remain regarding the link between GERD and extra-esophageal cancers. This nationwide cohort study investigated the risk of developing head and neck cancers (HNCs) among patients with GERD. METHODS: Newly diagnosed GERD pat...περισσότερα »
A typical megaesophagus: interesting imaging for diagnosis.
[image: http:--http://ift.tt/1Zbeyup] Related Articles *A typical megaesophagus: interesting imaging for diagnosis.* Chin Med J (Engl). 2015 May 20;128(10):1418 Authors: Zhu SB, Zhu J, Yan M, Liu Y PMID: 25963368 [PubMed - indexed for MEDLINE] from #ENT via xlomafota13 on Inoreader http://ift.tt/253RZLY via IFTTT
Mortality trend and predictors of mortality in dysphagic stroke patients postpercutaneous endoscopic gastrostomy.
[image: http:--http://ift.tt/1Zbeyup] Related Articles *Mortality trend and predictors of mortality in dysphagic stroke patients postpercutaneous endoscopic gastrostomy.* Chin Med J (Engl). 2015 May 20;128(10):1331-5 Authors: Jiang YL, Ruberu N, Liu XS, Xu YH, Zhang ST, Chan DK Abstract BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) feeding is widely used in stroke patients suffering from persistent dysphagia; however, predicting the risks and benefits of PEG insertion in the individual patient is difficult. The aim of our study was to investigate if candidate risk factors... περισσότερα »
Arytenoid cartilage chondroma.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Arytenoid cartilage chondroma.* Auris Nasus Larynx. 2015 Oct;42(5):428-30 Authors: Lee DH, Kim JH, Yoon TM, Lee JK, Lim SC Abstract Arytenoid chondroma is an extremely rare benign cartilaginous tumor. We report a case of a patient with arytenoid chondroma initially mimicking laryngopharyngeal reflux. Clinicians should consider the possibility of the arytenoid chondroma in the differential diagnosis of patients with vocal cord palsy, or arytenoid swelling caused by laryngopharyngeal reflux. PMID: 25960446 [PubMed ... περισσότερα »
A Novel Technique of Anti-reflux Esophagogastrostomy Following Left Thoracoabdominal Esophagectomy for Carcinoma of the Esophagogastric Junction.
[image: http:--production.springer.de-OnlineReso] Related Articles *A Novel Technique of Anti-reflux Esophagogastrostomy Following Left Thoracoabdominal Esophagectomy for Carcinoma of the Esophagogastric Junction.* World J Surg. 2015 Sep;39(9):2359-61 Authors: Mine S, Nunobe S, Watanabe M Abstract We developed an anti-reflux technique of intrathoracic esophagogastrostomy, based on the "Kamikawa procedure" or "Double flap technique", which is sometimes used in Japan after open proximal gastrectomy for early upper gastric cancer. We applied this technique to four patients with tumo... περισσότερα »
Experimental pulmonary fibrosis in rats with chronic gastric acid reflux esophagitis.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Experimental pulmonary fibrosis in rats with chronic gastric acid reflux esophagitis.* Auris Nasus Larynx. 2015 Oct;42(5):382-4 Authors: Shimazu R, Aoki S, Kuratomi Y Abstract OBJECTIVE: To elucidate the association between gastric acid reflux and respiratory diseases by studying the histological changes of the lower airway in rats with chronic acid reflux esophagitis. METHODS: An experimental rat model of chronic acid reflux esophagitis was surgically created. The lower airways of these rats were histologically ... περισσότερα »
Outcome for Asymptomatic Recurrence Following Laparoscopic Repair of Very Large Hiatus Hernia.
[image: http:--production.springer.de-OnlineReso] Related Articles *Outcome for Asymptomatic Recurrence Following Laparoscopic Repair of Very Large Hiatus Hernia.* J Gastrointest Surg. 2015 Aug;19(8):1385-90 Authors: Wang Z, Bright T, Irvine T, Thompson SK, Devitt PG, Watson DI Abstract BACKGROUND: Radiological follow-up following repair of large hiatus hernias have identified recurrence rates of 20-30%, although most are small and asymptomatic. Whether patients will eventually develop clinical problems is uncertain. This study evaluated the outcome for individuals identified with... περισσότερα »
Speech Articulatory Characteristics of Individuals With Dentofacial Deformity.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Speech Articulatory Characteristics of Individuals With Dentofacial Deformity.* J Craniofac Surg. 2015 Sep;26(6):1835-9 Authors: de Almeida Prado DG, Filho HN, Berretin-Felix G, Brasolotto AG Abstract PURPOSE: To analyze the speech articulatory characteristics of individuals with dentofacial deformities (DFD) and assess differences compared to individuals with dentofacial balance. METHODS: Sixty individuals participated, being 30 presenting DFD (19 with class III and 11 class II skeletal malocclusion, 18 women and... περισσότερα »
Achievement Gap in Reading Is Present as Early as First Grade and Persists through Adolescence.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Achievement Gap in Reading Is Present as Early as First Grade and Persists through Adolescence.* J Pediatr. 2015 Nov;167(5):1121-5.e2 Authors: Ferrer E, Shaywitz BA, Holahan JM, Marchione KE, Michaels R, Shaywitz SE Abstract OBJECTIVES: To determine if differences between dyslexic and typical readers in their reading scores and verbal IQ are evident as early as first grade and whether the trajectory of these differences increases or decreases from childhood to adolescence. STUDY DESIGN: The subjects were the 414 ... περισσότερα »
Early Language Learning and the Social Brain.
Related Articles *Early Language Learning and the Social Brain.* Cold Spring Harb Symp Quant Biol. 2014;79:211-20 Authors: Kuhl PK Abstract Explaining how every typically developing child acquires language is one of the grand challenges of cognitive neuroscience. Historically, language learning provoked classic debates about the contributions of innately specialized as opposed to general learning mechanisms. Now, new data are being brought to bear from studies that employ magnetoencephalograph (MEG), electroencephalograph (EEG), magnetic resonance imaging (MRI), and diffusion te...περισσότερα »
Asymmetries in the exploitation of phonetic features for word recognition.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *Asymmetries in the exploitation of phonetic features for word recognition.* J Acoust Soc Am. 2015 Apr;137(4):EL307-13 Authors: Martin A, Peperkamp S Abstract French listeners' reliance on voicing, manner, and place was tested in a mispronunciation detection task. Mispronounced words were more likely to be recognized when the mispronunciation concerned voicing rather than manner or place. This indicates that listeners rely less on the former than on the latter for the purposes of word recognition. Further, the role of ... περισσότερα »
Novel mechanism-based therapeutics for androgen axis blockade in castration-resistant prostate cancer.
*Novel mechanism-based therapeutics for androgen axis blockade in castration-resistant prostate cancer.* Curr Opin Endocrinol Diabetes Obes. 2016 Mar 14; Authors: Teply BA, Antonarakis ES Abstract PURPOSE OF REVIEW: Understanding the mechanisms by which castration-resistant prostate cancer (CRPC) progresses provides an opportunity to identify novel therapeutic strategies to treat this disease. This understanding has led to approaches to attack prostate cancer's androgen axis in unique ways. This review will examine the classes of novel therapies for androgen axis blockade in CRPC... περισσότερα »
Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine.
*Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine.* ACS Nano. 2016 Mar 15; Authors: Fais S, O'Driscoll L, Borras FE, Buzas E, Camussi G, Cappello F, Carvalho J, Cordeiro da Silva A, Del Portillo H, El Andaloussi S, Ficko Trček T, Furlan R, Hendrix A, Gursel I, Kralj-Iglic V, Kaeffer B, Kosanovic M, Lekka ME, Lipps G, Logozzi M, Marcilla A, Sammar M, Llorente A, Nazarenko I, Oliveira C, Pocsfalvi G, Rajendran L, Raposo G, Rohde E, Siljander P, van Niel G, Vasconcelos MH, Yáñez-Mó M, Yliperttula ML, Zarovni N, Zavec AB, Giebel B Abstract Recent resea... περισσότερα »
Low compliance with guidelines for re-staging in high-grade T1 bladder cancer and the potential impact on patient outcomes in the province of Alberta.
*Low compliance with guidelines for re-staging in high-grade T1 bladder cancer and the potential impact on patient outcomes in the province of Alberta.* Can Urol Assoc J. 2016 Jan-Feb;10(1-2):33-8 Authors: Gotto GT, Shea-Budgell MA, Dean Ruether J Abstract INTRODUCTION: Despite high-level evidence of benefit, early repeat resection (ERR) among high-grade T1 bladder cancer (HGT1-BC) patients remains low in several non-Canadian jurisdictions and rates in Canada are largely unreported. We evaluated rates of ERR and trends over time in Alberta. We also examined factors associated wit...περισσότερα »
Glioma Stem Cells and Their Microenvironments: Providers of Challenging Therapeutic Targets.
*Glioma Stem Cells and Their Microenvironments: Providers of Challenging Therapeutic Targets.* Stem Cells Int. 2016;2016:5728438 Authors: Codrici E, Enciu AM, Popescu ID, Mihai S, Tanase C Abstract Malignant gliomas are aggressive brain tumors with limited therapeutic options, possibly because of highly tumorigenic subpopulations of glioma stem cells. These cells require specific microenvironments to maintain their "stemness," described as perivascular and hypoxic niches. Each of those niches induces particular signatures in glioma stem cells (e.g., activation of Notch signaling,... περισσότερα »
Assessment of multifactor gene-environment interactions and ovarian cancer risk: candidate genes, obesity, and hormone-related risk factors.
*Assessment of multifactor gene-environment interactions and ovarian cancer risk: candidate genes, obesity, and hormone-related risk factors.* Cancer Epidemiol Biomarkers Prev. 2016 Mar 14; Authors: Usset JL, Raghavan R, Tyrer JP, McGuire V, Sieh W, Webb P, Chang-Claude J, Rudolph A, Anton-Culver H, Berchuck A, Brinton LA, Cunningham JM, deFazio A, Doherty JA, Edwards RP, Gayther SA, Gentry-Maharaj A, Goodman MT, Hogdall E, Jensen A, Johnatty SE, Kiemeney LA, Kjaer SK, Larson MC, Lurie G, Massuger L, Menon U, Modugno F, Moysich KB, Ness RB, Pike MC, Ramus SJ, Rossing MA, Rothstein... περισσότερα »
Education Research: Neurology resident education: Trending skills, confidence, and professional preparation.
*Education Research: Neurology resident education: Trending skills, confidence, and professional preparation.* Neurology. 2016 Mar 15;86(11):e112-7 Authors: Jordan JT, Mayans D, Schneider L, Adams N, Khawaja AM, Engstrom J Abstract OBJECTIVE: To survey US-trained graduating neurology residents who are American Academy of Neurology members, in an effort to trend perceived quality and completeness of graduate neurology education. METHODS: An electronic survey was sent to all American Academy of Neurology members graduating from US neurology residency programs in the Spring of 2014. ... περισσότερα »
Development and Evaluation of a Hematology-Oriented Clinical Research Training Program in Latin America.
*Development and Evaluation of a Hematology-Oriented Clinical Research Training Program in Latin America.* J Cancer Educ. 2016 Mar 15; Authors: Sung L, Rego E, Riva E, Elwood J, Basso J, Clayton CP, Mikhael J Abstract The objectives of the study were to describe the development of a patient-oriented clinical research training program in a low- or middle-income country (LMIC) setting, to describe perceived benefits of the program and barriers to application, and to make recommendations for future training programs. The program was developed by the American Society of Hematology in...περισσότερα »
Dual energy CT in radiotherapy: Current applications and future outlook.
*Dual energy CT in radiotherapy: Current applications and future outlook.* Radiother Oncol. 2016 Mar 11; Authors: van Elmpt W, Landry G, Das M, Verhaegen F Abstract Dual energy CT (DECT) scanners are nowadays available in many radiology departments. For radiotherapy purposes, new strategies using DECT imaging are investigated to optimize radiation treatment for multiple steps in the radiotherapy chain. This review describes how DECT based methods can be used for electron density estimation, effective atomic number decomposition and contrast material quantification. Clinical radiot...περισσότερα »
Hexaminolevulinate hydrochloride blue-light flexible cystoscopy in the detection and follow-up of nonmuscle-invasive bladder cancer: cost consequences during outpatient surveillance in Sweden.
*Hexaminolevulinate hydrochloride blue-light flexible cystoscopy in the detection and follow-up of nonmuscle-invasive bladder cancer: cost consequences during outpatient surveillance in Sweden.* Future Oncol. 2016 Mar 15; Authors: Dansk V, Malmström PU, Bläckberg M, Malmenäs M Abstract AIM: This study explored the cost consequences of introducing hexaminolevulinate hydrochloride-guided blue-light flexible cystoscopy (HAL BLFC) as an adjunct to white-light flexible cystoscopy compared with white-light flexible cystoscopy alone, for the detection and management of nonmuscle invasiv...περισσότερα »
Temporal Trends and Predictors for Cancer Clinical Trial Availability for Medically Underserved Populations.
[image: http:--highwire.stanford.edu-icons-exter] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Temporal Trends and Predictors for Cancer Clinical Trial Availability for Medically Underserved Populations.* Oncologist. 2015 Jun;20(6):674-82 Authors: Gerber DE, Lakoduk AM, Priddy LL, Yan J, Xie XJ Abstract BACKGROUND: Lack of access to available cancer clinical trials has been cited as a key factor limiting trial accrual, particularly among medically underserved populations. We examined the trends and factors in clinical trial availability within a major U.S. safety-net h... περισσότερα »
Adenoid cystic carcinoma of the head and neck
: A single-institution's analysis of 45 consecutive cases over a 29–year period via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology [image: alertIcon.gif] Publication date: Available online 15 March 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Ivica Lukšić, Sandra Baranović, Petar Suton, Dražena Gerbl Objective(s)Herein, we report a series of patients with head and neck adenoid cystic carcinoma (ACC) with respect to treatment modalities, recurrence, survival and prognostic factors.Study designBetween August 1984 and December 2013... περισσότερα »
Denosumab-Related Osteonecrosis of the Jaws
Evaluation of a Surgical Treatment of via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology [image: alertIcon.gif] Publication date: Available online 15 March 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Sarina E.C. Pichardo, J.P.Richard van Merkesteyn PurposeDenosumab, a monoclonal antibody, is a relatively new antiresorptive agent that has recently shown a serious side effect: denosumab-related osteonecrosis of the jaws (DRONJ). The purpose of this study was to retrospectively observe the efficacy of the combined surgical and an... περισσότερα »
Morphological condylar changes and temporomandibular disorders (TMDs)
Are condylar morphological changes associated with temporomandibular disorders in orthognathic patients? via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology [image: alertIcon.gif] Publication date: Available online 15 March 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Zulma Catherine, Delphine S. Courvoisier, Paolo Scolozzi ObjectiveTo determine the association between morphological condylar changes and temporomandibular disorders (TMDs) in orthognathic patients.Study DesignData from 89 patients were analyzed. Temporomandibular d... περισσότερα »
The Efficacy of Botulinum Toxin for the Treatment of Trigeminal and Post-Herpetic Neuralgia
: A Systematic Review with Meta-analyses via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 15 March 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Thomas Shackleton, Saravanan Ram, Misty Black, Jon Ryder, Glenn T. Clark, Reyes Enciso ObjectiveTo evaluate the efficacy of a Botulinum toxin type A (BoTN-A) in treating trigeminal neuralgia (TN) and post-herpetic neuralgia (PHN).Study DesignThree databases were searched: Medline, Web of Science and Cochrane Library. Search was restricted to English a... περισσότερα »
Repositioning of the levator muscle : Submucous cleft palate
Submucous cleft palate: outcomes after primary repair with repositioning of the levator muscle in 51 consecutive patients: Abstract I report the incidence of hypernasal resonance, nasal emission, and fistula after intravelar surgery with retropositioning of the levator muscle by a single surgeon in a consecutive series of 51 patients who presented with symptomatic submucous cleft palate. Intravelar veloplasty with repositioning of the levator muscle was highly effective in that 37/51 patients (73%) achieved either normal or mild and inconsistent resonance (p < 0.0001), and 39 (7... περισσότερα »
Atypical presentations of sinonasal inverted papilloma: Surgical management and influence on the recurrence rate
Atypical presentations of sinonasal inverted papilloma: Surgical management and influence on the recurrence rate: Abstract:Background: Sinonasal inverted papilloma (SNIP), classically, is a unilateral benign tumor of the nasal lateral wall. Numerous variations have been observed, depending on location, bilateral presentation, or association with nasal polyposis. Objective: The aim of this work was to describe atypical presentations of SNIPs with their management specificities and to assess their influence on the recurrence rate in a large case series. Methods: A retrospe... περισσότερα »
Extensive versus functional endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps and asthma: A 1-year study
Extensive versus functional endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps and asthma: A 1-year study: Abstract:Background: Functional endoscopic sinus surgery (FESS) is considered to be the standard procedure for chronic rhinosinusitis with nasal polyps (CRSwNP). However, for CRSwNP that accompanies asthma, the results are not satisfying. Extensive endoscopic sinus surgery (EESS) aimed at reducing the inflammatory load has been indicated as a viable option for refractory chronic rhinosinusitis. Objective: To evaluate the clinical outcomes and safety o... περισσότερα »
Squamous cell carcinoma antigen as a diagnostic marker of nasal inverted papilloma
Squamous cell carcinoma antigen as a diagnostic marker of nasal inverted papilloma: Abstract:Background: Serum squamous cell carcinoma antigen (SCCA) levels are elevated in sinonasal inverted papilloma (IP). However, the relationship between tumor volume and SCCA level, and the influence of skin or pulmonary diseases in which the SCCA level is high, have not been established. Objective: To clarify whether the level of serum SCCA can be used as a diagnostic marker of IP. Methods: Serum SCCA level was measured in 30 patients with IP (IP group) and 57 with inflammatory dise... περισσότερα »
Medical treatment of pediatric chronic rhinosinusitis
Problem-based learning discussion: Medical treatment of pediatric chronic rhinosinusitis: Abstract:This problem-based learning case focused on the approach to evaluation and management of a 5-year old girl who was “always sick” with sinus infections. The discussion unfolds in a “real life” scenario, i.e., based on information available to the clinician initially and after the acquisition of laboratory data, and, ultimately, after sinus surgery. Emphasis is placed on the differential diagnosis of the patient's symptoms, discussion of the initial management strategy for chronic rhi... περισσότερα »
Video Assisted Thoracoscopic Surgical Enucleation of a Giant Esophageal Leiomyoma Presenting with Persistent Cough.
*Video Assisted Thoracoscopic Surgical Enucleation of a Giant Esophageal Leiomyoma Presenting with Persistent Cough.* Case Rep Surg. 2016;2016:7453259 Authors: Mujawar P, Pawar T, Chavan RN Abstract Esophageal leiomyoma is a relatively rare tumor of esophagus but it is the most common benign neoplasm of the esophagus. Small esophageal leiomyoma can be observed but larger ones and those producing symptoms should be excised. As observed for other esophageal tumors, dysphagia is its main symptom. Traditionally, open thoracotomy and enucleation are its main treatment but in the last ... περισσότερα »
Phase I Study of Docetaxel, Cisplatin, and 5-Fluorouracil Chemoradiotherapy for Local or Metastatic Esophageal Cancer.
*Phase I Study of Docetaxel, Cisplatin, and 5-Fluorouracil Chemoradiotherapy for Local or Metastatic Esophageal Cancer.* Anticancer Res. 2016 Mar;36(3):987-94 Authors: Iwasaki K, Osaka Y, Tachibana S, Suda T, Ota Y, Hoshino S, Tsuchida A Abstract BACKGROUND/AIM: Chemoradiotherapy outcomes for unresectable esophageal cancer remain poor. We designed a phase I study of docetaxel, cisplatin (CDDP), and 5-fluorouracil (5-FU) chemoradiotherapy. PATIENTS AND METHODS: Patients with T4 or M1 esophageal squamous cell carcinoma were enrolled. They received 2 chemotherapy cycles every 4 weeks... περισσότερα »
[Current Status of Perioperative Rehabilitation in Patients who Undergo Esophagectomy for Cancer].
*[Current Status of Perioperative Rehabilitation in Patients who Undergo Esophagectomy for Cancer].* Kyobu Geka. 2016 Jan;69(1):59-64 Authors: Oikawa M, Hanada M, Hidaka S, Nagayasu T, Kozu R Abstract The esophagectomy for esophageal cancer is major surgery and has the highest rate of postoperative pulmonary complications. Respiratory physiotherapy in patients undergoing esophagectomy has been applied to improve oxygenation and airway secretion clearance. Recently, the utility and effectiveness of enhanced recovery after surgery for gastroenterological surgery have been reported ... περισσότερα »
[Perioperative Rehabilitation for Patients with Esophageal Cancer].
*[Perioperative Rehabilitation for Patients with Esophageal Cancer].* Kyobu Geka. 2016 Jan;69(1):53-8 Authors: Hirose C, Takeuchi H, Ishikawa A, Kawakubo H, Tsuji T, Kitagawa Y Abstract Transthoracic esophagectomy for patients with esophageal cancer is one of the most invasive of all gastrointestinal surgery. Postoperative management and surgical techniques are improved. However, many patients are more elderly or suffering from comorbid diseases or in malnutrition status. In order to prevent for postoperative complications after esophagectomy, especially for respiratory complicati...περισσότερα »
[Perioperative Oral Management for Esophageal Cancer Patients].
*[Perioperative Oral Management for Esophageal Cancer Patients].* Kyobu Geka. 2016 Jan;69(1):35-9 Authors: Makino T, Yamasaki M, Fujii N, Tanaka N, Nohara K, Doki Y Abstract Aspiration pneumonia, known as one of the most common postoperative complication after esophagectomy for esophageal cancer, can be critical profoundly affecting upon postoperative course of patients. Since oral bacteria can be one of causes for development of postoperative pneumonia, perioperative oral management has very important role in reducing morbidity and improving function of dysphagia. We started peri... περισσότερα »
[Current Status and Effectiveness of Perioperative Oral Health Care Management for Lung Cancer and Esophageal Cancer Patients].
*[Current Status and Effectiveness of Perioperative Oral Health Care Management for Lung Cancer and Esophageal Cancer Patients].* Kyobu Geka. 2016 Jan;69(1):30-4 Authors: Nishino T, Takizawa H, Yoshida T, Inui T, Takasugi H, Matsumoto D, Kawakita N, Inoue S, Sakiyama S, Tangoku A, Azuma M, Yamamura Y Abstract The effectiveness of perioperative oral health care management to decrease the risk of postoperative pneumonia have been reported lately. Since 2014, we introduced perioperative oral health care management for lung cancer and esophageal cancer patients. We report current stat... περισσότερα »
Monitoring disease progression and treatment efficacy with circulating tumor cells in esophageal squamous cell carcinoma: A case report.
Related Articles *Monitoring disease progression and treatment efficacy with circulating tumor cells in esophageal squamous cell carcinoma: A case report.* World J Gastroenterol. 2015 Jul 7;21(25):7921-8 Authors: Qiao YY, Lin KX, Zhang Z, Zhang DJ, Shi CH, Xiong M, Qu XH, Zhao XH Abstract This study investigated whether changes in circulating tumor cell (CTC) numbers reflect tumor progression and treatment efficacy in esophageal squamous cell carcinoma (ESCC). A 47-year-old male patient with ESCC is presented in this case study. The patient was evaluated for a series of serum tum... περισσότερα »
Premalignant and malignant lesions of the heterotopic pancreas in the esophagus: a case report and review of the literature.
Related Articles *Premalignant and malignant lesions of the heterotopic pancreas in the esophagus: a case report and review of the literature.* J Gastrointestin Liver Dis. 2015 Jun;24(2):235-9 Authors: Ulrych J, Fryba V, Skalova H, Krska Z, Krechler T, Zogala D Abstract Heterotopic pancreas is a congenital pathology of the gastrointestinal tract, particularly rare in the esophagus. Both symptomatology and findings during preoperative examinations are non-specific and therefore do not often lead to an accurate diagnosis, which is usually revealed only by histopathological assessme... περισσότερα »
The crucial role of SRPK1 in TGF-β-induced proliferation and apoptosis in the esophageal squamous cell carcinomas.
Related Articles *The crucial role of SRPK1 in TGF-β-induced proliferation and apoptosis in the esophageal squamous cell carcinomas.* Med Oncol. 2015 Jul;32(7):209 Authors: Ren G, Sheng L, Liu H, Sun Y, An Y, Li Y Abstract In recent years, transforming growth factor-β (TGF-β) and the serine-arginine protein kinase 1 (SRPK1) have been recommended as a key signal mediator that is involved in oncogenesis. However, the mechanisms underlying TGF-β-SRPK1 pathway-mediated proliferation and apoptosis in the esophageal squamous cell carcinomas (ESCC) have not been well featured till now.... περισσότερα »
[Interpretation of ultrasound findings in otorhinolaryngology. Salivary glands, paraganglioma, angioma, esophagus, hypopharynx, extra cranial vessels and temporomandibular joint].
Related Articles *[Interpretation of ultrasound findings in otorhinolaryngology. Salivary glands, paraganglioma, angioma, esophagus, hypopharynx, extra cranial vessels and temporomandibular joint].* HNO. 2015 Jun;63(6):453-65; quiz 466-7 Authors: Bozzato A Abstract The second part of this continuing medical education article focuses on sonographic assessment of the salivary glands, cervical paraganglioma, angioma, esophagus, extra cranial blood vessels and the temporomandibular joint. The currently available minimally invasive therapeutic options (e. g. sialendoscopy, lithotrips... περισσότερα »
A Novel Technique of Anti-reflux Esophagogastrostomy Following Left Thoracoabdominal Esophagectomy for Carcinoma of the Esophagogastric Junction.
Related Articles *A Novel Technique of Anti-reflux Esophagogastrostomy Following Left Thoracoabdominal Esophagectomy for Carcinoma of the Esophagogastric Junction.* World J Surg. 2015 Sep;39(9):2359-61 Authors: Mine S, Nunobe S, Watanabe M Abstract We developed an anti-reflux technique of intrathoracic esophagogastrostomy, based on the "Kamikawa procedure" or "Double flap technique", which is sometimes used in Japan after open proximal gastrectomy for early upper gastric cancer. We applied this technique to four patients with tumors of the esophagogastric junction. All four pati... περισσότερα »
Differences in the Sino-Nasal Outcome Test 22 and visual analog scale symptom scores in chronic rhinosinusitis with and without nasal polyps
Differences in the Sino-Nasal Outcome Test 22 and visual analog scale symptom scores in chronic rhinosinusitis with and without nasal polyps: Abstract:Background: Chronic rhinosinusitis (CRS) with and without polyps has a high impact on health-related quality of life (HRQL), but the difference in HRQL and symptom presentation between two clinical phenotypes of CRS has not been specifically evaluated before now. Objective: To evaluate patterns of symptoms and HRQL disease-specific domains affected in patients with CRS by comparing differences between two clinical phenotypes, ... περισσότερα »
Involvement of Staphylococcus aureus and Moraxella catarrhalis in Japanese cedar pollinosis
Involvement of Staphylococcus aureus and Moraxella catarrhalis in Japanese cedar pollinosis: Abstract:Background and Objective: From mid February to the end of March, each year ∼30% of Japanese have Japanese cedar pollinosis. Moreover, 10‐50% of patients with this pollinosis exhibit nasal manifestations in the preseason. These patients have a predominance of neutrophils but not eosinophils in nasal swabs and high carriage of Staphylococcus aureus. We hypothesized that S. aureus or other bacteria and associated neutrophilia were involved in preseasonal symptoms. Methods: Cyt... περισσότερα »
Deoxyribonuclease I sensitive bacteria and implications for the sinus microbiome
Dead or alive: Deoxyribonuclease I sensitive bacteria and implications for the sinus microbiome: Abstract:Background: Recently, there has been tremendous interest in the sinus microbiome and how it relates to disease. However, a lack of a standardized sample collection and DNA extraction methods makes comparison of results across studies nearly impossible. Furthermore, current techniques fail to identify which components of the microbiome are actually alive within the host at the time of sampling. Objective: To develop and optimize a method to differentiate which bacterial s... περισσότερα »
Cognitive predictors of perceptual adaptation to accented speech.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *Cognitive predictors of perceptual adaptation to accented speech.* J Acoust Soc Am. 2015 Apr;137(4):2015-24 Authors: Banks B, Gowen E, Munro KJ, Adank P Abstract The present study investigated the effects of inhibition, vocabulary knowledge, and working memory on perceptual adaptation to accented speech. One hundred young, normal-hearing adults listened to sentences spoken in a constructed, unfamiliar accent presented in speech-shaped background noise. Speech Reception Thresholds (SRTs) corresponding to 50% speech rec... περισσότερα »
A Novel Technique of Anti-reflux Esophagogastrostomy Following Left Thoracoabdominal Esophagectomy for Carcinoma of the Esophagogastric Junction.
[image: http:--production.springer.de-OnlineReso] Related Articles *A Novel Technique of Anti-reflux Esophagogastrostomy Following Left Thoracoabdominal Esophagectomy for Carcinoma of the Esophagogastric Junction.* World J Surg. 2015 Sep;39(9):2359-61 Authors: Mine S, Nunobe S, Watanabe M Abstract We developed an anti-reflux technique of intrathoracic esophagogastrostomy, based on the "Kamikawa procedure" or "Double flap technique", which is sometimes used in Japan after open proximal gastrectomy for early upper gastric cancer. We applied this technique to four patients with tumo... περισσότερα »
Measuring the effects of spectral smearing and enhancement on speech recognition in noise for adults and children.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *Measuring the effects of spectral smearing and enhancement on speech recognition in noise for adults and children.* J Acoust Soc Am. 2015 Apr;137(4):2004-14 Authors: Nittrouer S, Tarr E, Wucinich T, Moberly AC, Lowenstein JH Abstract Broadened auditory filters associated with sensorineural hearing loss have clearly been shown to diminish speech recognition in noise for adults, but far less is known about potential effects for children. This study examined speech recognition in noise for adults and children using simul... περισσότερα »
Experimental pulmonary fibrosis in rats with chronic gastric acid reflux esophagitis.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Experimental pulmonary fibrosis in rats with chronic gastric acid reflux esophagitis.* Auris Nasus Larynx. 2015 Oct;42(5):382-4 Authors: Shimazu R, Aoki S, Kuratomi Y Abstract OBJECTIVE: To elucidate the association between gastric acid reflux and respiratory diseases by studying the histological changes of the lower airway in rats with chronic acid reflux esophagitis. METHODS: An experimental rat model of chronic acid reflux esophagitis was surgically created. The lower airways of these rats were histologically ... περισσότερα »
Gender typicality in children's speech: A comparison of boys with and without gender identity disorder.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *Gender typicality in children's speech: A comparison of boys with and without gender identity disorder.* J Acoust Soc Am. 2015 Apr;137(4):1995-2003 Authors: Munson B, Crocker L, Pierrehumbert JB, Owen-Anderson A, Zucker KJ Abstract This study examined whether boys with gender identity disorder (GID) produced less prototypically male speech than control boys without GID, a possibility that has been suggested by clinical observations. Two groups of listeners participated in tasks where they rated the gender typicality o... περισσότερα »
Outcome for Asymptomatic Recurrence Following Laparoscopic Repair of Very Large Hiatus Hernia.
[image: http:--production.springer.de-OnlineReso] Related Articles *Outcome for Asymptomatic Recurrence Following Laparoscopic Repair of Very Large Hiatus Hernia.* J Gastrointest Surg. 2015 Aug;19(8):1385-90 Authors: Wang Z, Bright T, Irvine T, Thompson SK, Devitt PG, Watson DI Abstract BACKGROUND: Radiological follow-up following repair of large hiatus hernias have identified recurrence rates of 20-30%, although most are small and asymptomatic. Whether patients will eventually develop clinical problems is uncertain. This study evaluated the outcome for individuals identified with... περισσότερα »
Identification of high-pass filtered male, female, and child vowels: The use of high-frequency cues.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *Identification of high-pass filtered male, female, and child vowels: The use of high-frequency cues.* J Acoust Soc Am. 2015 Apr;137(4):1971-82 Authors: Donai JJ, Paschall DD Abstract Vowels are characteristically described according to low-frequency resonance characteristics, which are presumed to provide the requisite information for identification. Classically, the study of vowel perception has focused on the lowest formant frequencies, typically F1, F2, and F3. Lehiste and Peterson [Phonetica 4, 161-177 (1959)] in... περισσότερα »
The binaural masking-level difference of mandarin tone detection and the binaural intelligibility-level difference of mandarin tone recognition in the presence of speech-spectrum noise.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *The binaural masking-level difference of mandarin tone detection and the binaural intelligibility-level difference of mandarin tone recognition in the presence of speech-spectrum noise.* PLoS One. 2015;10(3):e0120977 Authors: Ho CY, Li PC, Chiang YC, Young ST, Chu WC Abstract Binaural hearing involves using information relating to the differences between the signals that arrive at the two ears, and it can make it easier to detect and recognize signals in a noisy environment. This phenome... περισσότερα »
The influence of cochlear spectral processing on the timing and amplitude of the speech-evoked auditory brain stem response.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *The influence of cochlear spectral processing on the timing and amplitude of the speech-evoked auditory brain stem response.* J Neurophysiol. 2015 Jun 1;113(10):3683-91 Authors: Nuttall HE, Moore DR, Barry JG, Krumbholz K, de Boer J Abstract The speech-evoked auditory brain stem response (speech ABR) is widely considered to provide an index of the quality of neural temporal encoding in the central auditory pathway. The aim of the present study was to evaluate the extent to which the speech ABR is shaped by spectra... περισσότερα »
Composite Tooth Fillings | www.TheDCDentist.com
The post Composite Tooth Fillings | www.TheDCDentist.com appeared first on Family Dentistry and Cosmetic Surgery Clinic. from #Dental via xlomafota13 on Inoreader http://ift.tt/1nNRTpV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Mitteilungen der DGKFO
from #Dental via xlomafota13 on Inoreader http://ift.tt/1TNi9ib via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Cone beam computed tomographic evaluation of nutrient canals and foramina in the anterior region of the mandible
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
Abstract Purpose To investigate the incidence and anatomical location of mandibular nutrient canals (NCs) originating from the mandibular canal using dental cone beam computed tomography (CBCT). Methods CBCT images from 105 patients were examined to evaluate the presence, number, diameter, and course of NCs. Results NCs and their foramina were bilaterally located in 17 (16.2 %) images. The mean diameters of NCs and foramina were 0.9 ± 0.4 (range, 0.2–3.2) mm and 0.9 ± 0.4 (0.2–2.1) mm, respectively. NCs coursed through the mandibular incisor region up to the lingual surface of t...περισσότερα »
New anatomo-radiological findings of the lateral pterygoid muscle
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
Abstract Purpose The discrepancies in the literature regarding the anatomy of the temporomandibular joint (TMJ), particularly at the level of the lateral pterygoid muscle, led us to compare plastinated section techniques and magnetic resonance imaging (MRI) to enable the better interpretation of both, and to describe the features of the lateral pterygoid muscle and the exact location of its insertions. Methods A total of 24 blocks of human TMJ were used. Seven were studied by MRI, obtaining images of the oblique-sagittal, oblique-coronal, and axial planes. Four of these blocks we... περισσότερα »
Spleen tyrosine kinase induces MUC5AC expression in human airway epithelial cell
Spleen tyrosine kinase induces MUC5AC expression in human airway epithelial cell: Abstract:Background: MUC5AC, a major secreted mucin, is increased in chronic inflammatory airway disease. Spleen tyrosine kinase (SYK) is a mediator, which acts as an important regulator of intracellular signal transduction in the inflammatory response. SYK was originally identified in hematopoietic cells, and its expression in some nonhematopoietic cells, including respiratory epithelial cells, was recently demonstrated. However, the effects of SYK on mucin secretion in human airway epithelial ce... περισσότερα »
Cytofunctional changes in nasal ciliated cells in patients treated with hyaluronate after nasal surgery
Cytofunctional changes in nasal ciliated cells in patients treated with hyaluronate after nasal surgery: Abstract:Background: Hyaluronic acid (HA) plays a significant role in tissue repair of mucosal surfaces and, consequently, in surgical injury remodelling of nasal mucosa. Objective: To assess the effect of high-molecular-weight HA administered by aerosol on the morphofunctional recovery of ciliated cells damaged by surgical trauma. Methods: A single-blind, prospective, randomized trial was carried out with 94 patients who were randomly assigned, after endoscopic turbino... περισσότερα »
Smoking, not human papilloma virus infection, is a risk factor for recurrence of sinonasal inverted papilloma
Smoking, not human papilloma virus infection, is a risk factor for recurrence of sinonasal inverted papilloma: Abstract:Background: The recurrence rate of sinonasal inverted papillomas (SNIP) is 15‐20%. However, few studies have investigated patient-dependent factors related to recurrence of SNIPs. Objective: To analyze risk factors, including human papilloma virus (HPV) infection and smoking, as well as other factors, for recurrence of SNIPs. Methods: Fifty-four patients who were diagnosed with SNIP and underwent surgery were enrolled: 39 men and 15 women, with the ... περισσότερα »
Chronic rhinosinusitis and extraesophageal reflux: Who is the candidate for antireflux treatment?
Chronic rhinosinusitis and extraesophageal reflux: Who is the candidate for antireflux treatment?: Abstract:Background: During the past decade, extraesophageal reflux (EER) has been hypothesized to be one of the possible factors that contribute to the worsening of chronic rhinosinusitis (CRS). However, the relationship remains indeterminate due to its complexity, and it is not clear whether antireflux treatment is indicated for patients with recurrent CRS and who would benefit from it. Objective: The aim of the study was to determine the severity of EER in patients with var... περισσότερα »
A comparison of spectral estimation methods for the analysis of sibilant fricatives.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *A comparison of spectral estimation methods for the analysis of sibilant fricatives.* J Acoust Soc Am. 2015 Apr;137(4):EL248-54 Authors: Reidy PF Abstract It has been argued that, to ensure accurate spectral feature estimates for sibilants, the spectral estimation method should include a low-variance spectral estimator; however, no empirical evaluation of estimation methods in terms of feature estimates has been given. The spectra of /s/ and /ʃ/ were estimated with different methods that varied the pre-emphasis filte... περισσότερα »
Amplitude fluctuations in a masker influence lexical segmentation in cochlear implant users.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *Amplitude fluctuations in a masker influence lexical segmentation in cochlear implant users.* J Acoust Soc Am. 2015 Apr;137(4):2070-9 Authors: Perry TT, Kwon BJ Abstract Normal-hearing listeners show masking release, or better speech understanding in a fluctuating-amplitude masker than in a steady-amplitude masker, but most cochlear implant (CI) users consistently show little or no masking release even in artificial conditions where masking release is highly anticipated. The current study examined the hypothesis that... περισσότερα »
The association between serum lead and total immunoglobulin E levels according to allergic sensitization
The association between serum lead and total immunoglobulin E levels according to allergic sensitization: Abstract:Background: Results of several studies showed that blood lead concentration is positively associated with total immunoglobulin E (IgE) value. However, no study has investigated whether allergic sensitization could be responsible for the association between lead exposure and total IgE value. Objective: We investigated whether there was difference in the association between lead exposure and the total IgE value, depending on the presence or absence of Dermatophago...περισσότερα »
Septoplasty in children
Septoplasty in children: Abstract:Objectives: Physicians have long had concerns about the potential harmful effects of pediatric septoplasties on the nasoseptal growth process because septal cartilage is important for the growth and development of the face. Methods: In this review article, pediatric septoplasty and its indications are discussed, together with a literature survey. In addition, overviews of development of the nasal skeleton from neonate to adult, nasal growth, and cartilaginous septum are presented. Important issues and comments on pediatric septoplasties are ... περισσότερα »
Evaluation of residual symptoms: A method to assess surgical outcomes for nasal polyposis
Evaluation of residual symptoms: A method to assess surgical outcomes for nasal polyposis: Abstract:Background: The assessment of residual symptoms after endoscopic sinus surgery for nasal polyposis (NP) could be an accurate way to evaluate surgical outcomes. Objective: To assess the residual symptoms and their severity at 6 weeks and 7 months after radical ethmoidectomy for NP. Methods: Sixty-five patients who had surgery for NP were included in this prospective study. Six residual symptoms (nasal obstruction, anterior rhinorrhea, postnasal discharge, olfactory dist... περισσότερα »
Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.
*Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.* Chem Senses. 2016 Mar 14; Authors: Lemon CH, Kang Y, Li J Abstract Oral temperature is a component and modifier of taste perception. Both trigeminal (V) and taste-sensitive cells, including those in the nucleus of the solitary tract (NTS), can respond to oral temperature. However, functional associations in thermal sensitivity between V and gustatory neurons are poorly understood. To study this we recorded electrophysiological responses to oral stimulation with cool (9, 15, 25, 32,...περισσότερα »
Still Eating Despite Decreased Olfactory Pleasure-The Influence of Odor Liking and Wanting on Food Intake.
*Still Eating Despite Decreased Olfactory Pleasure-The Influence of Odor Liking and Wanting on Food Intake.* Chem Senses. 2016 Mar 14; Authors: Sailer U, Triscoli C, Croy I Abstract Typically, the subjective pleasantness of an odor decreases after it has been repeatedly smelled. This study investigates how the pleasantness ("liking") and the wish to be further exposed to the same odor ("wanting") are affected by variety on a longer time scale, and how they relate to actual food intake. Twenty-five participants rated a coconut odor presented 120 times for its liking and wanting be... περισσότερα »
Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.
*Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.* Chem Senses. 2016 Mar 14; Authors: Lemon CH, Kang Y, Li J Abstract Oral temperature is a component and modifier of taste perception. Both trigeminal (V) and taste-sensitive cells, including those in the nucleus of the solitary tract (NTS), can respond to oral temperature. However, functional associations in thermal sensitivity between V and gustatory neurons are poorly understood. To study this we recorded electrophysiological responses to oral stimulation with cool (9, 15, 25, 32,...περισσότερα »
Still Eating Despite Decreased Olfactory Pleasure-The Influence of Odor Liking and Wanting on Food Intake.
*Still Eating Despite Decreased Olfactory Pleasure-The Influence of Odor Liking and Wanting on Food Intake.* Chem Senses. 2016 Mar 14; Authors: Sailer U, Triscoli C, Croy I Abstract Typically, the subjective pleasantness of an odor decreases after it has been repeatedly smelled. This study investigates how the pleasantness ("liking") and the wish to be further exposed to the same odor ("wanting") are affected by variety on a longer time scale, and how they relate to actual food intake. Twenty-five participants rated a coconut odor presented 120 times for its liking and wanting be... περισσότερα »
Activated Hippo/Yes-Associated Protein Pathway Promotes Cell Proliferation and Anti-apoptosis in Endometrial Stromal Cells of Endometriosis.
*Activated Hippo/Yes-Associated Protein Pathway Promotes Cell Proliferation and Anti-apoptosis in Endometrial Stromal Cells of Endometriosis.* J Clin Endocrinol Metab. 2016 Mar 15;:jc20161120 Authors: Song Y, Fu J, Zhou M, Xiao L, Feng X, Chen H, Huang W Abstract CONTEXT: The imbalance in cell proliferation and apoptosis is considered an important role in the pathogenesis of endometriosis, but the exact mechanisms remains unclear. A newly established signaling pathway-Hippo/Yes-associated protein (YAP) pathway plays a critical role in the proliferation and apoptosis processes. How...περισσότερα »
Quality-of-life outcomes after sinus surgery in allergic fungal rhinosinusitis versus nonfungal chronic rhinosinusitis
Quality-of-life outcomes after sinus surgery in allergic fungal rhinosinusitis versus nonfungal chronic rhinosinusitis: Abstract:Background: Given the differences in pathophysiology between allergic fungal rhinosinusitis (AFRS) and other chronic rhinosinusitis (CRS) subgroups, it remains unclear about whether these patients respond differently to a combination of surgical and medical treatments. Objective: To evaluate differences in quality-of-life (QoL) outcomes for a cohort of patients who underwent endoscopic sinus surgery (ESS) for CRS. Methods: This retrospective rev... περισσότερα »
Prevalence of allergic rhinitis symptoms and positive skin-prick test results in patients with dry eye
Prevalence of allergic rhinitis symptoms and positive skin-prick test results in patients with dry eye: Abstract:Background: Dry eye is characterized by decreased tear production and/or increased evaporation rates of the tear film barrier. Allergic rhinitis is an inflammatory disease that develops through immunoglobulin E in the rhino-ocular mucosa due to allergens. To investigate the prevalence of allergic rhinitis symptoms and positive skin-prick test results in patients with dry eye. Methods: This is a case-control study. The study included 57 patients with dry eye and 4... περισσότερα »
Voice Alterations in Patients With Spinocerebellar Ataxia Type 7 (SCA7): Clinical-Genetic Correlations
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Spinocerebellar ataxia type 7 (SCA7) is an inherited neurodegenerative disease caused by the expansion of a cytosine-adenine-guanine triplet located in the coding region of the ATXN7 gene, which is characterized by cerebellar ataxia, pigmentary macular degeneration, and dysarthria. Although dysarthria is a common feature in various SCA, its clinical characterization has been barely approached. from […]
Determinants of biofilm formation and cleanability of titanium surfaces
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Abstract Objective The aim of the present study was to analyze biofilm formation on four different titanium-based surfaces (machined titanium zirconium (TiZr) alloy, M; machined, acid-etched TiZr alloy, modMA; machined, sandblasted, acid-etched TiZr alloy, modSLA; and micro-grooved titanium aluminum vanadium alloy, TAV MG) in an experimental human model. Material and methods Custom-made discs were mounted […]
Quantification of dose uncertainties in cumulated dose estimation compared to planned dose in prostate IMRT
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
In prostate IMRT, the objectives were to quantify, for the bladder and the rectum: (i) the dose difference (DD) between the planned dose (PD) and the estimated cumulated dose (ECD) by deformable image registration (DIR); (ii) the dose accumulation uncertainties (DAU). from Rathiotherapy via ola Kala on Inoreader http://ift.tt/1pnnNun via IFTTT from #Med Blogs by […]
Hardware complications and failure of three-unit zirconia-based and porcelain-fused-metal implant-supported fixed dental prostheses: a retrospective cohort study with up to 8 years
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Abstract Objective The aim of the present study was to assess the hardware complications and survival of three-unit implant-supported zirconia-based fixed dental prostheses (IZ) and implant-supported porcelain-fused-metal fixed dental prostheses (IP). Material and methods The study is a retrospective cohort study with up to 8 years (mean 4.8 years) follow-up. Patients with conventional three-unit implant-supported […]
Resonance Tuning in Three Girl Choristers
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
The phenomenon of resonance tuning, whereby a singer modifies the shape of their vocal tract to increase the acoustic power output, is commonly exploited across large pitch ranges by professional sopranos and has been observed to a lesser degree in nonexpert adult singers.This study considers the employment of two common resonance tuning techniques in experienced […]
Prevalence and Risk Factors for Voice Problems Among Soccer Coaches
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
The prevalence of voice problems has been investigated in various occupations, but research investigating sports coaches’ voice problems seems to be limited even if coaches are an occupational group whose work requires heavy voice use. The aim of this study was to determine the prevalence of voice problems among soccer coaches and identify risk factors […]
Voice Alterations in Patients With Spinocerebellar Ataxia Type 7 (SCA7): Clinical-Genetic Correlations
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Spinocerebellar ataxia type 7 (SCA7) is an inherited neurodegenerative disease caused by the expansion of a cytosine-adenine-guanine triplet located in the coding region of the ATXN7 gene, which is characterized by cerebellar ataxia, pigmentary macular degeneration, and dysarthria. Although dysarthria is a common feature in various SCA, its clinical characterization has been barely approached. from […]
Outcomes of the Memorial Sloan Kettering Cancer Center International General Surgical Oncology Fellowship
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Training of foreign medical graduates in surgical oncology may be an undervalued intervention to improve global cancer care. The aim of this work is to describe the design and results of a clinical training program for international surgeons from a single comprehensive cancer center. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UytPnN via IFTTT
[Perioperative Rehabilitation for Patients with Esophageal Cancer].
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
*[Perioperative Rehabilitation for Patients with Esophageal Cancer].* Kyobu Geka. 2016 Jan;69(1):53-8 Authors: Hirose C, Takeuchi H, Ishikawa A, Kawakubo H, Tsuji T, Kitagawa Y Abstract Transthoracic esophagectomy for patients with esophageal cancer is one of the most invasive of all gastrointestinal surgery. Postoperative management and surgical techniques are improved. However, many patients are more elderly or suffering from comorbid diseases or in malnutrition status. In order to prevent for postoperative complications after esophagectomy, especially for respiratory complicati...περισσότερα »
Mortality trend and predictors of mortality in dysphagic stroke patients postpercutaneous endoscopic gastrostomy.
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
[image: http:--http://ift.tt/1Zbeyup] Related Articles *Mortality trend and predictors of mortality in dysphagic stroke patients postpercutaneous endoscopic gastrostomy.* Chin Med J (Engl). 2015 May 20;128(10):1331-5 Authors: Jiang YL, Ruberu N, Liu XS, Xu YH, Zhang ST, Chan DK Abstract BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) feeding is widely used in stroke patients suffering from persistent dysphagia; however, predicting the risks and benefits of PEG insertion in the individual patient is difficult. The aim of our study was to investigate if candidate risk factors... περισσότερα »
Outcomes review of modern hearing preservation technique in cochlear implant.
*Outcomes review of modern hearing preservation technique in cochlear implant.* Auris Nasus Larynx. 2016 Mar 11; Authors: Nguyen S, Cloutier F, Philippon D, Côté M, Bussières R, Backous DD Abstract INTRODUCTION: Preservation of residual hearing in cochlear implantation is a main concern for patients and otologists. New electrode arrays as well as development of minimally invasive technique have allowed the expansion of indication criteria for cochlear implantation. The loss of residual low-frequency hearing is thought to be the result of many factors. Opinions differ in regards w... περισσότερα »
Vocal-fold vibration of patients with Reinke's edema observed using high-speed digital imaging.
*Vocal-fold vibration of patients with Reinke's edema observed using high-speed digital imaging.* Auris Nasus Larynx. 2016 Mar 11; Authors: Watanabe T, Kaneko K, Sakaguchi K, Takahashi H Abstract OBJECTIVE: We aimed to assess the vocal-fold vibration of patients with moderate-to-severe Reinke's edema using high-speed digital imaging (HSDI) and videostroboscopy and to confirm HSDI usefulness in examining the vocal folds with Reinke's edema. METHODS: We examined the vocal folds of seven patients (six severe and one moderate; six females and one male; aged 55-74 years; mean 64.7 year... περισσότερα »
Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.
*Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.* Clin Exp Otorhinolaryngol. 2016 Mar;9(1):80-4 Authors: Santos RS, Andrade MF, Alves Fde A, Kowalski LP, Perez DE Abstract OBJECTIVES: Metastasis of melanoma to the head and neck mucosa is a very unusual condition. The aim of this study was to report four cases of patients with metastatic melanoma in the head and neck mucosa treated at a single institution. METHODS: Clinical data were obtained from the medical records. All cases were histologically reviewed to confirm the diagnosis, and immunohistochemical ... περισσότερα »
Granulomatosis With Polyangiitis in Otolaryngologist Practice: A Review of Current Knowledge.
*Granulomatosis With Polyangiitis in Otolaryngologist Practice: A Review of Current Knowledge.* Clin Exp Otorhinolaryngol. 2016 Mar;9(1):8-13 Authors: Wojciechowska J, Krajewski W, Krajewski P, Kręcicki T Abstract Granulomatosis with polyangiitis (GPA) is an idiopathic vasculitis of medium and small arteries, characterized by necrotizing granulomatous inflammation. GPA typically affects upper and lower respiratory tract with coexisting glomerulonephritis. This disease is generally characterized by antineutrophil cytoplasm antibodies (ANCA), nevertheless, there are rare cases with...περισσότερα »
Speech Articulatory Characteristics of Individuals With Dentofacial Deformity.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Speech Articulatory Characteristics of Individuals With Dentofacial Deformity.* J Craniofac Surg. 2015 Sep;26(6):1835-9 Authors: de Almeida Prado DG, Filho HN, Berretin-Felix G, Brasolotto AG Abstract PURPOSE: To analyze the speech articulatory characteristics of individuals with dentofacial deformities (DFD) and assess differences compared to individuals with dentofacial balance. METHODS: Sixty individuals participated, being 30 presenting DFD (19 with class III and 11 class II skeletal malocclusion, 18 women and... περισσότερα »
Cytotoxic Effects of Intranasal Midazolam on Nasal Mucosal Tissue.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Cytotoxic Effects of Intranasal Midazolam on Nasal Mucosal Tissue.* J Craniofac Surg. 2015 Sep;26(6):2008-12 Authors: Ozbay I, Kucur C, Değer A, Ital I, Kasim CM, Oghan F Abstract The aim of this experimental study was to investigate the cytotoxic effects of intranasal midazolam on nasal mucosal tissue in rats. Forty healthy rats were randomly divided into 5 groups. Group 1 (n = 8) was the control group, group 2 (n = 8) received intranasal saline, group 3 (n = 8) received intranasal midazolam, group 4 (n = 8) rece... περισσότερα »
Effects of Quercetin in a Mouse Model of Experimental Dry Eye.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Effects of Quercetin in a Mouse Model of Experimental Dry Eye.* Cornea. 2015 Sep;34(9):1130-6 Authors: Oh HN, Kim CE, Lee JH, Yang JW Abstract PURPOSE: To evaluate the effect of treatment with quercetin in a mouse model of dry eye. METHODS: 0.5% quercetin eye drops were prepared and an experimental dry eye model was induced in NOD.B10.H2(b) mice through desiccation stress. The mice were divided into 3 groups according to the treatment regimen: the DS 10D group (desiccation stress for 10 days), the phosphate buffer... περισσότερα »
Direct fascia lata reconstruction to reduce donor site morbidity in endoscopic endonasal extended surgery: a pilot study.
*Direct fascia lata reconstruction to reduce donor site morbidity in endoscopic endonasal extended surgery: a pilot study.* Clin Neurol Neurosurg. 2016 Mar 7;144:59-63 Authors: Vitali M, Canevari FR, Cattalani A, Grasso V, Somma T, Barbanera A Abstract OBJECTIVE: Fascia lata is a validated source of autologous grafts, adopted by many surgical figures throughout different types of reconstructive procedures. Postoperative pain and muscle prolapse are frequent complications after harvesting fascia lata; donor site morbidity causes delayed mobilization and increased lenght of hospital... περισσότερα »
[Apical petrositis, osteomyelitis of the base of the skull bones and of the first cervical vertebra in a 5 year-old children following chicken pox].
*[Apical petrositis, osteomyelitis of the base of the skull bones and of the first cervical vertebra in a 5 year-old children following chicken pox].* Vestn Otorinolaringol. 2016;81(1):61-63 Authors: Bogomil'sky MR, Polunin MM, Zelikovich EI, Soldatsky YL, Burova OV Abstract This publication was designed to describe a rare case of development of apicalpetrositis in a child presenting with acute otitis mediafollowing chicken pox experienced in the preceding period. We carried out the study with the use of computed tomography (CT) that demonstrated destruction of the temporal bone,... περισσότερα »
Endoscopic Resection of Giant Ethmoid Osteomas with the Assistance of an Image-guidance System.
*Endoscopic Resection of Giant Ethmoid Osteomas with the Assistance of an Image-guidance System.* Anticancer Res. 2016 Mar;36(3):1325-30 Authors: Wang Y, Li D, Jiang A, Zhang H, Sun Y, Liu Z, Song X Abstract AIM: To investigate the minimally invasive ablation of giant osteoma of the ethmoid sinuses endonasally with the assistance of an image-guidance system. PATIENTS AND METHODS: A retrospective analysis was carried out on 12 patients with osteomas of ethmoid sinuses treated by endoscopic surgery with the help of a navigation system from April 2005 to October 2013. RESULTS: Osteoma... περισσότερα »
Outcomes review of modern hearing preservation technique in cochlear implant.
*Outcomes review of modern hearing preservation technique in cochlear implant.* Auris Nasus Larynx. 2016 Mar 11; Authors: Nguyen S, Cloutier F, Philippon D, Côté M, Bussières R, Backous DD Abstract INTRODUCTION: Preservation of residual hearing in cochlear implantation is a main concern for patients and otologists. New electrode arrays as well as development of minimally invasive technique have allowed the expansion of indication criteria for cochlear implantation. The loss of residual low-frequency hearing is thought to be the result of many factors. Opinions differ in regards w... περισσότερα »
A Geometric Classification of Jaw Deformities.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *A Geometric Classification of Jaw Deformities.* J Oral Maxillofac Surg. 2015 Dec;73(12 Suppl):S26-31 Authors: Gateno J, Alfi D, Xia JJ, Teichgraeber JF PMID: 26608152 [PubMed - indexed for MEDLINE] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1VbPH9g via IFTTT
Recombinant Human Thyroid Stimulating Hormone versus Thyroid Hormone Withdrawal for Radioactive Iodine Treatment of Differentiated Thyroid Cancer with Nodal Metastatic Disease.
*Recombinant Human Thyroid Stimulating Hormone versus Thyroid Hormone Withdrawal for Radioactive Iodine Treatment of Differentiated Thyroid Cancer with Nodal Metastatic Disease.* J Oncol. 2016;2016:6496750 Authors: Wolfson RM, Rachinsky I, Morrison D, Driedger A, Spaic T, Van Uum SH Abstract Introduction. Recombinant human thyroid stimulating hormone (rhTSH) is approved for preparation of thyroid remnant ablation with radioactive iodine (RAI) in low risk patients with well differentiated thyroid cancer (DTC). We studied the safety and efficacy of rhTSH preparation for RAI treatm...περισσότερα »
Diminished Quality of Life and Increased Brain Functional Connectivity in Patients with Hypothyroidism after Total Thyroidectomy.
*Diminished Quality of Life and Increased Brain Functional Connectivity in Patients with Hypothyroidism after Total Thyroidectomy.* Thyroid. 2016 Mar 15; Authors: Shin YW, Choi YM, Kim HS, Kim DJ, Jo HJ, O'Donnell BF, Jang EK, Kim TY, Shong Y, Hong JP, Kim WB Abstract BACKGROUND: Acute hypothyroidism induced by thyroid hormone withdrawal (THW) in patients with thyroid cancer after total thyroidectomy can affect mood and quality of life (QoL). While loss or dysregulation of thyroid hormone (TH) has these well-known behavioral consequences, the effects of TH alterations on brain fu... περισσότερα »
Future Meetings.
*Future Meetings.* Thyroid. 2016 Mar;26(3):476-477 Authors: PMID: 26978322 [PubMed - as supplied by publisher] from thyroid via a.lsfakia on Inoreader http://ift.tt/1pnELJa via IFTTT
Hypothyroidism in patients treated with radiotherapy for head and neck carcinoma: standardised long-term follow-up study.
*Hypothyroidism in patients treated with radiotherapy for head and neck carcinoma: standardised long-term follow-up study.* J Laryngol Otol. 2016 Mar 15;:1-4 Authors: Alba JR, Basterra J, Ferrer JC, Santonja F, Zapater E Abstract OBJECTIVE: Hypothyroidism is a common complication when radiotherapy is part of the treatment for head and neck tumours. This study aimed to show the incidence of hypothyroidism and possible risk factors in these patients. METHODS: Factors related to the population, tumour, treatment and occurrence of hypothyroidism were analysed in 241 patients diagnosed ...περισσότερα »
Previous tonsillectomy modifies odds of tonsil and base of tongue cancer.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
*Previous tonsillectomy modifies odds of tonsil and base of tongue cancer.* Br J Cancer. 2016 Mar 15; Authors: Zevallos JP, Mazul AL, Rodriguez N, Weissler MC, Brennan P, Anantharaman D, Abedi-Ardekani B, Neil Hayes D, Olshan AF Abstract BACKGROUND: Tonsillectomy is a commonly performed surgical procedure that involves removal of the palatine tonsils. The purpose of this study is to examine the association between previous tonsillectomy and odds of oropharyngeal squamous cell carcinoma (OPSCC) in a large population-based case-control study. We hypothesise that previous tonsillecto... περισσότερα »
Functional Sharing of the Upper Orbicularis Oris Muscle for the Reconstruction of the Lower Lip.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Functional Sharing of the Upper Orbicularis Oris Muscle for the Reconstruction of the Lower Lip.* J Craniofac Surg. 2015 Sep;26(6):1969-71 Authors: Yazar M, Yazar SK, Kozanoğlu E, Karsidag S Abstract The lip reconstruction is a very controversial topic in plastic surgery and many flaps have been described for this purpose. Despite all of the interventions, some patients still have problems such as drooling and gingival show that decrease their quality of life. In this study, the authors report a patient whose low... περισσότερα »
Management for squamous cell carcinoma of the nasal cavity and ethmoid sinus: A single institution experience.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Management for squamous cell carcinoma of the nasal cavity and ethmoid sinus: A single institution experience.* Auris Nasus Larynx. 2015 Oct;42(5):377-81 Authors: Homma A, Nakamaru Y, Sakashita T, Onimaru R, Terasaka S, Tsuchiya K, Yoshida D, Yasuda K, Hatakeyama H, Furusawa J, Mizumachi T, Kano S, Shirato H, Fukuda S Abstract OBJECTIVE: Here we report our experience of patients with squamous cell carcinoma (SCC) of the nasal cavity and ethmoid sinus (NC&ES) together with an analysis of treatment outcomes. METHOD...περισσότερα »
Endocrine disruptors and female cancer: Informing the patients (Review).
Related Articles *Endocrine disruptors and female cancer: Informing the patients (Review).* Oncol Rep. 2015 Jul;34(1):3-11 Authors: Del Pup L, Mantovani A, Luce A, Cavaliere C, Facchini G, Di Francia R, Caraglia M, Berretta M Abstract Pollutants altering the endocrine system, known as endocrine disruptors (ED), may modify the risk of female cancers. The carcinogenic effect of ED on humans has been confirmed by experimental studies for various substances including pesticides, DDT, dioxins, phthalates, bisphenol A, diethylstilbestrol, as well as heavy metals, but it is difficult to...περισσότερα »
Choice of Starting Dose for Biopharmaceuticals in First-in-Human Phase I Cancer Clinical Trials.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Choice of Starting Dose for Biopharmaceuticals in First-in-Human Phase I Cancer Clinical Trials.* Oncologist. 2015 Jun;20(6):653-9 Authors: Hansen AR, Cook N, Ricci MS, Razak A, Le Tourneau C, McKeever K, Roskos L, Dixit R, Siu LL, Hinrichs MJ Abstract BACKGROUND: First-in-human (FIH) trials of low-molecular-weight anticancer agents conventionally derive a safe start dose (SD) from one-tenth the severely toxic dose in 10% of rodents or one-sixth the highest nonseverely toxic dose (HNSTD) in nonrodent species. No ... περισσότερα »
Mass-spectrometry-based molecular characterization of extracellular vesicles: lipidomics and proteomics.
[image: http:--pubs.acs.org-images-pubmed-acspub] Related Articles *Mass-spectrometry-based molecular characterization of extracellular vesicles: lipidomics and proteomics.* J Proteome Res. 2015 Jun 5;14(6):2367-84 Authors: Kreimer S, Belov AM, Ghiran I, Murthy SK, Frank DA, Ivanov AR Abstract This review discusses extracellular vesicles (EVs), which are submicron-scale, anuclear, phospholipid bilayer membrane enclosed vesicles that contain lipids, metabolites, proteins, and RNA (micro and messenger). They are shed from many, if not all, cell types and are present in biological f... περισσότερα »
In vivo toxicity, metabolism and pharmacokinetic properties of FAK inhibitor 14 or Y15 (1, 2, 4, 5-benzenetetramine tetrahydrochloride).
[image: http:--production.springer.de-OnlineReso] Related Articles *In vivo toxicity, metabolism and pharmacokinetic properties of FAK inhibitor 14 or Y15 (1, 2, 4, 5-benzenetetramine tetrahydrochloride).* Arch Toxicol. 2015 Jul;89(7):1095-101 Authors: Golubovskaya V, Curtin L, Groman A, Sexton S, Cance WG Abstract Y15 or inhibitor 14 (1,2,4,5-benzenetetramine tetrahydrochloride) is a potent and specific inhibitor of focal adhesion kinase that inhibits its autophosphorylation activity, decreases the viability of cancer cells, and blocks tumor growth. In this preclinical study, we ... περισσότερα »
Evaluation of a regional German interdisciplinary oral health programme for children from birth to 5 years of age
AbstractObjectives The aim of this prospective birth cohort study was to evaluate the effect of the interdisciplinary oral health programme (OHP) for early childhood caries (ECC) in 5-year-old German children. Material and methods All parents of newborns (*n* = 1162; born 2009/2010) were visited after birth by the communal newborn visiting service of Jena, Thuringia, and advised on general and dental health. In the first year of life, children were invited to attend a dental examination in the Jena University Hospital. Participating children were included in a caries-risk-related r... περισσότερα »
Micro Computed Tomography Study of Filling Material Removal from Oval-shaped Canals by Using Rotary, Reciprocating, and Adaptive Motion Systems
[image: gr1.sml] This study evaluated filling material removal from distal oval-shaped canals of mandibular molars with rotary, reciprocating, and adaptive motion systems by using micro computed tomography. from #Dental via xlomafota13 on Inoreader http://ift.tt/1UfkTVI via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.
*Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.* Chem Senses. 2016 Mar 14; Authors: Lemon CH, Kang Y, Li J Abstract Oral temperature is a component and modifier of taste perception. Both trigeminal (V) and taste-sensitive cells, including those in the nucleus of the solitary tract (NTS), can respond to oral temperature. However, functional associations in thermal sensitivity between V and gustatory neurons are poorly understood. To study this we recorded electrophysiological responses to oral stimulation with cool (9, 15, 25, 32,...περισσότερα »
Still Eating Despite Decreased Olfactory Pleasure-The Influence of Odor Liking and Wanting on Food Intake.
*Still Eating Despite Decreased Olfactory Pleasure-The Influence of Odor Liking and Wanting on Food Intake.* Chem Senses. 2016 Mar 14; Authors: Sailer U, Triscoli C, Croy I Abstract Typically, the subjective pleasantness of an odor decreases after it has been repeatedly smelled. This study investigates how the pleasantness ("liking") and the wish to be further exposed to the same odor ("wanting") are affected by variety on a longer time scale, and how they relate to actual food intake. Twenty-five participants rated a coconut odor presented 120 times for its liking and wanting be... περισσότερα »
Newly acquired kiwi fruit allergy after bone marrow transplantation from a kiwi-allergic donor
[image: cover.gif?v=1&s=9ed7c8a5ea459f238bf70b29] Abstract Background The phenomenon of allergy transfer from an allergic donor to a non-allergic recipient via hematopoietic cell transplantation has been described by several reports. However, it could not yet been conclusively shown that allergic reaction of the recipient is elicited by the donor's cells. Objectives In the case of a 46-year-old male patient who – for the first time in his life – had two episodes of oral allergic syndrome upon kiwi consumption after having received myeloablative hematopoietic stem cell transplant... περισσότερα »
Foreign Body Reaction After Cochlear Implantation: A Case Report.
[image: http:--http://ift.tt/1Zbeyup] Related Articles *Foreign Body Reaction After Cochlear Implantation: A Case Report.* Chin Med J (Engl). 2015 Aug 5;128(15):2124-5 Authors: Xin Y, Yuan YS, Chi FL, Wang J, Yang JM PMID: 26228231 [PubMed - indexed for MEDLINE] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1XuAw9H via IFTTT
Modification of Blair Approach With a Modified Endaural Component to Access the Parotid Region.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Modification of Blair Approach With a Modified Endaural Component to Access the Parotid Region.* J Craniofac Surg. 2015 Sep;26(6):1972-4 Authors: Fernández Olarte H, Gómez-Delgado A, Rivera-Guzmán A Abstract OBJECTIVE: The aim of this study is to present our experience with a modification of the Blair approach to the parotid area, by means of a modified endaural component, which provides both excellent exposure and optimal functional and esthetic results, mainly over the preauricular area. PATIENTS AND METHODS: A ... περισσότερα »
Pterygoid Plate Fractures: Not Limited to Le Fort Fractures.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Pterygoid Plate Fractures: Not Limited to Le Fort Fractures.* J Craniofac Surg. 2015 Sep;26(6):1823-5 Authors: Garg RK, Alsheik NH, Afifi AM, Gentry LR Abstract Pterygoid plate fractures are often described in the setting of Le Fort fractures. The goal of this study was to define other craniofacial fracture patterns causing injury to the pterygoid plates. A retrospective review of computed tomography (CT) scans obtained on craniofacial trauma patients over a 5-year period revealed 209 patients with pterygoid plate... περισσότερα »
Evaluation of the eosinophil-to-lymphocyte ratio in pediatric patients with allergic rhinitis
Evaluation of the eosinophil-to-lymphocyte ratio in pediatric patients with allergic rhinitis: Abstract:Background: Allergic rhinitis is a type 1 hypersensitivity reaction of the nasal mucosa, the primary mediator of which is immunoglobulin E. Allergic rhinitis occurs in children and adolescents. Objective: This study examined the relationship between allergies and the eosinophil-to-lymphocyte ratio in children with allergic rhinitis with a positive skin-prick test. Study Design: This study was planned and performed as a case-control study. Methods: There were 695 pat... περισσότερα »
Nasal septal deviation with obstructive symptoms
Nasal septal deviation with obstructive symptoms: Association found with asthma but not with other general health problems: Abstract:Background: Nasal septal deviation (NSD) is a very common deformity. Because it may induce chronic upper airway obstruction in the nose, clinicians encounter some patients who have concerns about whether this can be a risk factor for general health. However, the influence of NSD on general health has rarely been studied. Objective: To determine associations between NSD, especially NSD with nasal obstructive symptom, and general health problems ...περισσότερα »
Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.
*Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.* Chem Senses. 2016 Mar 14; Authors: Lemon CH, Kang Y, Li J Abstract Oral temperature is a component and modifier of taste perception. Both trigeminal (V) and taste-sensitive cells, including those in the nucleus of the solitary tract (NTS), can respond to oral temperature. However, functional associations in thermal sensitivity between V and gustatory neurons are poorly understood. To study this we recorded electrophysiological responses to oral stimulation with cool (9, 15, 25, 32,...περισσότερα »
Still Eating Despite Decreased Olfactory Pleasure-The Influence of Odor Liking and Wanting on Food Intake.
*Still Eating Despite Decreased Olfactory Pleasure-The Influence of Odor Liking and Wanting on Food Intake.* Chem Senses. 2016 Mar 14; Authors: Sailer U, Triscoli C, Croy I Abstract Typically, the subjective pleasantness of an odor decreases after it has been repeatedly smelled. This study investigates how the pleasantness ("liking") and the wish to be further exposed to the same odor ("wanting") are affected by variety on a longer time scale, and how they relate to actual food intake. Twenty-five participants rated a coconut odor presented 120 times for its liking and wanting be... περισσότερα »
Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.
*Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.* Chem Senses. 2016 Mar 14; Authors: Lemon CH, Kang Y, Li J Abstract Oral temperature is a component and modifier of taste perception. Both trigeminal (V) and taste-sensitive cells, including those in the nucleus of the solitary tract (NTS), can respond to oral temperature. However, functional associations in thermal sensitivity between V and gustatory neurons are poorly understood. To study this we recorded electrophysiological responses to oral stimulation with cool (9, 15, 25, 32,...περισσότερα »
Still Eating Despite Decreased Olfactory Pleasure-The Influence of Odor Liking and Wanting on Food Intake.
*Still Eating Despite Decreased Olfactory Pleasure-The Influence of Odor Liking and Wanting on Food Intake.* Chem Senses. 2016 Mar 14; Authors: Sailer U, Triscoli C, Croy I Abstract Typically, the subjective pleasantness of an odor decreases after it has been repeatedly smelled. This study investigates how the pleasantness ("liking") and the wish to be further exposed to the same odor ("wanting") are affected by variety on a longer time scale, and how they relate to actual food intake. Twenty-five participants rated a coconut odor presented 120 times for its liking and wanting be... περισσότερα »
Parents' beliefs and knowledge about the management of acute otitis media: a qualitative study.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Parents' beliefs and knowledge about the management of acute otitis media: a qualitative study.* BMC Fam Pract. 2015;16:82 Authors: Hansen MP, Howlett J, Del Mar C, Hoffmann TC Abstract BACKGROUND: Acute otitis media is a common reason for antibiotic prescribing, despite strong evidence that antibiotics provide minimal benefit. Studies have demonstrated that patients' (or parents') expectations of antibiotics often influence general practitioners' (GPs) decision to prescribe antibiotics... περισσότερα »
Perioperative prophylactic antibiotics for skull base surgeries
Systematic review of the effectiveness of perioperative prophylactic antibiotics for skull base surgeries: Abstract:Background: Perioperative antibiotics are commonly used in endoscopic skull base surgeries as prophylaxis for infectious complications, *e.g.*, meningitis. The role of perioperative prophylactic antibiotics in endoscopic sinus surgery is unclear, and the routine use of prophylactic antibiotics in endoscopic skull base surgery is also highly debated. Currently, there is no formal recommendation for perioperative antibiotic use in skull base surgery, and regimens va... περισσότερα »
Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws?
Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws? A double-blind clinical trial: Recurrence is a major problem following the treatment of aggressive central giant cell granuloma (CGCG). The aim of this study was to compare the frequency of recurrence between patients who received calcitonin nasal spray after curettage of CGCGs and those who did not. A double-blind clinical trial was designed. Patients were allocated to one of two groups: those in the calcitonin group underwent curettage and received calcitonin salmon nasal spray 20... περισσότερα »
The anterior maxilla as a potential source of bone grafts
The anterior maxilla as a potential source of bone grafts: a morphometric cone beam computed tomography analysis of different anatomical areas: The aim of this research was to use cone beam computed tomography (CBCT) to analyze the volume, density, and morphology of the bone available in the anterior region of the maxilla, in order to investigate its potential as a source of bone grafts. Three independent zones were evaluated: the palatine process of the maxilla (PPM), anterior nasal spine (ANS), and subnasal bone (SN). The latter was analyzed bilaterally (SNR, SNL). One hundred CBCT...περισσότερα »
Middle ear capillary haemangioma
Middle ear capillary haemangioma: Review of literature and appraisal of management options: Abstract Infantile middle ear capillary haemangiomas (MECH) are a rare entity with only five reported cases in the literature. At present there is no consensus regarding the management of such lesions. Extra-cutaneous haemangiomas have been successfully managed with oral propranolol but not yet reported in MECH. We present a further case and appraise the management options. At present oral propranolol has not been used in the treatment of MECH. The literature suggests that infantile MECH ...περισσότερα »
Amphetamine-type stimulant use and the risk of injury or death as a result of a road-traffic accident: a systematic review of observational studies
European Neuropsychopharmacology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/22lxnMU via IFTTT
Correlation of free and total phenytoin serum concentrations in critically ill patients
Annals of Pharmacotherapy from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SSdcUo via IFTTT
The impact of traumatic brain injury on self-identity: a systematic review of the evidence for self-concept changes
Journal of Head Trauma Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/22lxlEQ via IFTTT
Comparing prospectively recorded posttraumatic amnesia duration with retrospective accounts
Journal of Head Trauma Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SSdcDT via IFTTT
Concordance of actigraphy with polysomnography in traumatic brain injury neurorehabilitation admissions
Journal of Head Trauma Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/22lxlEF via IFTTT
Randomized trial of standard pain control with or without gabapentin for pain related to radiation-induced mucositis in head and neck cancer
Randomized trial of standard pain control with or without gabapentin for pain related to radiation-induced mucositis in head and neck cancer: Radiation-induced mucositis (RIM) in chemoradiotherapy (CRT) for head and neck cancer (HNC) causes severe pain and worsens CRT compliance, QOL and outcome. Following retrospective reports, we conducted a randomized trial of the safety and efficacy of gabapentin for RIM-associated pain during CRT. AbstractObjective Radiation-induced mucositis (RIM) in chemoradiotherapy (CRT) for head and neck cancer (HNC) causes severe pain and worsens CRT co...περισσότερα »
Parents' beliefs and knowledge about the management of acute otitis media: a qualitative study.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Parents' beliefs and knowledge about the management of acute otitis media: a qualitative study.* BMC Fam Pract. 2015;16:82 Authors: Hansen MP, Howlett J, Del Mar C, Hoffmann TC Abstract BACKGROUND: Acute otitis media is a common reason for antibiotic prescribing, despite strong evidence that antibiotics provide minimal benefit. Studies have demonstrated that patients' (or parents') expectations of antibiotics often influence general practitioners' (GPs) decision to prescribe antibiotics... περισσότερα »
The Association Between Sensorineural Hearing Loss and Diabetes Mellitus in Poorly Controlled Patients Whose HbA1c >8
Clinical Study to Evaluate the Association Between Sensorineural Hearing Loss and Diabetes Mellitus in Poorly Controlled Patients Whose HbA1c >8: AbstractThe relationship between sensorineural hearing loss (SNHL) and Diabetes mellitus has been known since more than 150 years. The pathophysiology of diabetes related hearing loss is speculative. Hearing loss is usually, bilateral, gradual onset, affecting higher frequencies. This study aims at knowing the prevalence of SNHL in DM and its relation to age, sex, duration of DM and control of DM. A total of 50 type 2 diabetics of age gro... περισσότερα »
Prosthodontic Management of Xerostomic Patient
Prosthodontic Management of Xerostomic Patient: A Technical Modification.: Case Rep Dent. 2016;2016:8905891 Authors: Gurkar H, Venkatesh OY, Somashekar JM, Gowda MH, Dwivedi M, Ningthoujam I Abstract Xerostomia is often a contributing factor in both minor and serious health problems. It can affect nutrition and dental as well as psychological health. Common problems faced by such patients are glossitis, mucositis, angular cheilitis, dysgeusia, and difficulty in chewing and swallowing. One of the major problems associated with xerostomic patients is the poor tolerance and retention... περισσότερα »
Cellular microRNAs Repress Vesicular Stomatitis Virus but Not Theiler's Virus Replication.
Cellular microRNAs Repress Vesicular Stomatitis Virus but Not Theiler's Virus Replication.: Viruses. 2016;8(3) Authors: De Cock A, Michiels T Abstract Picornavirus' genomic RNA is a positive-stranded RNA sequence that also serves as a template for translation and replication. Cellular microRNAs were reported to interfere to different extents with the replication of specific picornaviruses, mostly acting as inhibitors. However, owing to the high error rate of their RNA-dependent RNA-polymerases, picornavirus quasi-species are expected to evolve rapidly in order to lose any detrime... περισσότερα »
Direct fascia lata reconstruction to reduce donor site morbidity in endoscopic endonasal extended surgery: a pilot study.
Direct fascia lata reconstruction to reduce donor site morbidity in endoscopic endonasal extended surgery: a pilot study.: Clin Neurol Neurosurg. 2016 Mar ;144:59-63 Authors: Vitali M, Canevari FR, Cattalani A, Grasso V, Somma T, Barbanera A Abstract OBJECTIVE: Fascia lata is a validated source of autologous grafts, adopted by many surgical figures throughout different types of reconstructive procedures. Postoperative pain and muscle prolapse are frequent complications after harvesting fascia lata; donor site morbidity causes delayed mobilization and increased lenght of hospital st... περισσότερα »
Video Assisted Thoracoscopic Surgical Enucleation of a Giant Esophageal Leiomyoma Presenting with Persistent Cough.
*Video Assisted Thoracoscopic Surgical Enucleation of a Giant Esophageal Leiomyoma Presenting with Persistent Cough.* Case Rep Surg. 2016;2016:7453259 Authors: Mujawar P, Pawar T, Chavan RN Abstract Esophageal leiomyoma is a relatively rare tumor of esophagus but it is the most common benign neoplasm of the esophagus. Small esophageal leiomyoma can be observed but larger ones and those producing symptoms should be excised. As observed for other esophageal tumors, dysphagia is its main symptom. Traditionally, open thoracotomy and enucleation are its main treatment but in the last ... περισσότερα »
[Perioperative Oral Management for Esophageal Cancer Patients].
*[Perioperative Oral Management for Esophageal Cancer Patients].* Kyobu Geka. 2016 Jan;69(1):35-9 Authors: Makino T, Yamasaki M, Fujii N, Tanaka N, Nohara K, Doki Y Abstract Aspiration pneumonia, known as one of the most common postoperative complication after esophagectomy for esophageal cancer, can be critical profoundly affecting upon postoperative course of patients. Since oral bacteria can be one of causes for development of postoperative pneumonia, perioperative oral management has very important role in reducing morbidity and improving function of dysphagia. We started peri... περισσότερα »
Palliative treatment of malignant dysphagia: stent by and await further instructions.
*Palliative treatment of malignant dysphagia: stent by and await further instructions.* Gastrointest Endosc. 2016 Apr;83(4):753-5 Authors: Kappelle WF, Vleggaar FP PMID: 26975282 [PubMed - in process] from Swallowing and Swallowing Disorders (Dysphagia) via a.lsfakia on Inoreader http://ift.tt/1QXcdjb via IFTTT
Gastroesophageal reflux and congenital gastrointestinal malformations.
[image: http:--http://ift.tt/1YyhL4R] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Gastroesophageal reflux and congenital gastrointestinal malformations.* World J Gastroenterol. 2015 Jul 28;21(28):8508-15 Authors: Marseglia L, Manti S, D'Angelo G, Gitto E, Salpietro C, Centorrino A, Scalfari G, Santoro G, Impellizzeri P, Romeo C Abstract Although the outcome of newborns with surgical congenital diseases (e.g., diaphragmatic hernia; esophageal atresia; omphalocele; gastroschisis) has improved rapidly with recent advances in perinatal intensive care and surgery, infant s... περισσότερα »
The disappointing performance of the new "Magnetic Sphincters": a wrong idea or a wrong realization?
Related Articles *The disappointing performance of the new "Magnetic Sphincters": a wrong idea or a wrong realization?* J Gastrointestin Liver Dis. 2015 Jun;24(2):149-50 Authors: Bortolotti M PMID: 26114172 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via a.lsfakia on Inoreader http://ift.tt/253S0Q8 via IFTTT
Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility.
[image: http:--ivyspring.com-images-linkout-ijbs] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility.* Int J Biol Sci. 2015;11(7):794-802 Authors: Chen J, Hou N, Zhang C, Teng Y, Cheng X, Li Z, Ren J, Zeng J, Li R, Wang W, Yang X, Lan Y Abstract As a master component of endosomal sorting complex required for transport proteins, hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) participates multiple cellular behaviors. However, the physiological role of Hgs in smooth muscle cells (SMCs) is by ... περισσότερα »
Four-branch Prosthetic Graft Used for Stanford Type A Aortic Dissection with Aberrant Right Subclavian Artery.
[image: http:--http://ift.tt/1Zbeyup] Related Articles *Four-branch Prosthetic Graft Used for Stanford Type A Aortic Dissection with Aberrant Right Subclavian Artery.* Chin Med J (Engl). 2015 Jun 5;128(11):1558 Authors: Ren CW, Lai YQ, Yang S, Xu SD, Sun LZ PMID: 26021518 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via a.lsfakia on Inoreader http://ift.tt/253S0PY via IFTTT
Incidence and Risk Factors of Abdominal Complications After Lung Transplantation.
[image: http:--production.springer.de-OnlineReso] Related Articles *Incidence and Risk Factors of Abdominal Complications After Lung Transplantation.* World J Surg. 2015 Sep;39(9):2274-81 Authors: Grass F, Schäfer M, Cristaudi A, Berutto C, Aubert JD, Gonzalez M, Demartines N, Ris HB, Soccal PM, Krueger T Abstract BACKGROUND: Due to the underlying diseases and the need for immunosuppression, patients after lung transplantation are particularly at risk for gastrointestinal (GI) complications that may negatively influence long-term outcome. The present study assessed the incidences... περισσότερα »
Acid reflux and head and neck cancer risk: A nationwide registry over 13 years.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Acid reflux and head and neck cancer risk: A nationwide registry over 13 years.* Auris Nasus Larynx. 2015 Oct;42(5):401-5 Authors: Kuo CL, Chen YT, Shiao AS, Lien CF, Wang SJ Abstract OBJECTIVE: Gastro-esophageal reflux disease (GERD) is a highly prevalent disorder; however, important questions remain regarding the link between GERD and extra-esophageal cancers. This nationwide cohort study investigated the risk of developing head and neck cancers (HNCs) among patients with GERD. METHODS: Newly diagnosed GERD pat...περισσότερα »
A typical megaesophagus: interesting imaging for diagnosis.
[image: http:--http://ift.tt/1Zbeyup] Related Articles *A typical megaesophagus: interesting imaging for diagnosis.* Chin Med J (Engl). 2015 May 20;128(10):1418 Authors: Zhu SB, Zhu J, Yan M, Liu Y PMID: 25963368 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via a.lsfakia on Inoreader http://ift.tt/253RZLY via IFTTT
Arytenoid cartilage chondroma.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Arytenoid cartilage chondroma.* Auris Nasus Larynx. 2015 Oct;42(5):428-30 Authors: Lee DH, Kim JH, Yoon TM, Lee JK, Lim SC Abstract Arytenoid chondroma is an extremely rare benign cartilaginous tumor. We report a case of a patient with arytenoid chondroma initially mimicking laryngopharyngeal reflux. Clinicians should consider the possibility of the arytenoid chondroma in the differential diagnosis of patients with vocal cord palsy, or arytenoid swelling caused by laryngopharyngeal reflux. PMID: 25960446 [PubMed ... περισσότερα »
Experimental pulmonary fibrosis in rats with chronic gastric acid reflux esophagitis.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Experimental pulmonary fibrosis in rats with chronic gastric acid reflux esophagitis.* Auris Nasus Larynx. 2015 Oct;42(5):382-4 Authors: Shimazu R, Aoki S, Kuratomi Y Abstract OBJECTIVE: To elucidate the association between gastric acid reflux and respiratory diseases by studying the histological changes of the lower airway in rats with chronic acid reflux esophagitis. METHODS: An experimental rat model of chronic acid reflux esophagitis was surgically created. The lower airways of these rats were histologically ... περισσότερα »
Future Meetings.
*Future Meetings.* Thyroid. 2016 Mar;26(3):476-477 Authors: PMID: 26978322 [PubMed - as supplied by publisher] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1pnELJa via IFTTT
Diminished Quality of Life and Increased Brain Functional Connectivity in Patients with Hypothyroidism after Total Thyroidectomy.
*Diminished Quality of Life and Increased Brain Functional Connectivity in Patients with Hypothyroidism after Total Thyroidectomy.* Thyroid. 2016 Mar 15; Authors: Shin YW, Choi YM, Kim HS, Kim DJ, Jo HJ, O'Donnell BF, Jang EK, Kim TY, Shong Y, Hong JP, Kim WB Abstract BACKGROUND: Acute hypothyroidism induced by thyroid hormone withdrawal (THW) in patients with thyroid cancer after total thyroidectomy can affect mood and quality of life (QoL). While loss or dysregulation of thyroid hormone (TH) has these well-known behavioral consequences, the effects of TH alterations on brain fu... περισσότερα »
An Interesting Association of Cystic Hygroma of the Neck and Lymphangioma Causing a Paediatric Swollen Tongue
Up to 75% of lymphatic malformations occur in the head and neck region. Of these, cystic hygromas and lymphangiomas have been widely reported; however they rarely occur in the same patient. We report the case of a 5-year-old girl who presented to the Department of Paediatrics of a district general hospital with a short history of recurrent, painful swelling of the anterior one-third of her tongue. She was reviewed under the joint care of the Oral and Maxillofacial Surgery and Otolaryngology Teams. Relevant past medical history included a previously excised cystic hygroma from her r...περισσότερα »
Next-Generation Genotyping by Digital PCR to Detect and Quantify the BRAF V600E Mutation in Melanoma Biopsies.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Next-Generation Genotyping by Digital PCR to Detect and Quantify the BRAF V600E Mutation in Melanoma Biopsies.* J Mol Diagn. 2015 Jul;17(4):366-73 Authors: Lamy PJ, Castan F, Lozano N, Montélion C, Audran P, Bibeau F, Roques S, Montels F, Laberenne AC Abstract The detection of the BRAF V600E mutation in melanoma samples is used to select patients who should respond to BRAF inhibitors. Different techniques are routinely used to determine BRAF status in clinical samples. However, low tumor cellularity and tumor het... περισσότερα »
Aetiology and pathology of otitis media with effusion in adult life.
*Aetiology and pathology of otitis media with effusion in adult life.* J Laryngol Otol. 2016 Mar 15;:1-7 Authors: Mills R, Hathorn I Abstract OBJECTIVES: To gather and analyse information concerning the aetiology and pathology of otitis media with effusion in adults. METHOD: A review of the English language literature from 1970 to the present was conducted. RESULTS: The available evidence suggests that otitis media with effusion in adult life is best viewed as a syndrome with a number of causes, including: infiltration of the eustachian tube by nasopharyngeal carcinoma and other l... περισσότερα »
Outcomes of synchronous pulmonary nodules detected on computed tomography in head and neck cancer patients: 12-year retrospective review of a consecutive cohort.
*Outcomes of synchronous pulmonary nodules detected on computed tomography in head and neck cancer patients: 12-year retrospective review of a consecutive cohort.* J Laryngol Otol. 2016 Mar 15;:1-6 Authors: Zammit-Maempel I, Kurien R, Paleri V Abstract OBJECTIVE: To investigate the long-term outcomes of pulmonary nodules detected on chest computed tomography in a consecutive cohort of patients with newly diagnosed or recurrent head and neck squamous cell cancer staged between 2001 and 2003. RESULTS: The study included 222 patients, 148 patients with newly diagnosed head and neck ... περισσότερα »
Temporomandibular joint involvement as a positive clinical prognostic factor in necrotising external otitis.
*Temporomandibular joint involvement as a positive clinical prognostic factor in necrotising external otitis.* J Laryngol Otol. 2016 Mar 15;:1-5 Authors: Yeheskeli E, Eta RA, Gavriel H, Kleid S, Eviatar E Abstract OBJECTIVE: Necrotising otitis externa is associated with high morbidity and mortality rates. This study investigated whether temporomandibular joint involvement had any prognostic effect on the course of necrotising otitis externa in patients who had undergone hyperbaric oxygen therapy after failed medical and sometimes surgical therapy. METHODS: A retrospective case ser... περισσότερα »
Hypothyroidism in patients treated with radiotherapy for head and neck carcinoma: standardised long-term follow-up study.
*Hypothyroidism in patients treated with radiotherapy for head and neck carcinoma: standardised long-term follow-up study.* J Laryngol Otol. 2016 Mar 15;:1-4 Authors: Alba JR, Basterra J, Ferrer JC, Santonja F, Zapater E Abstract OBJECTIVE: Hypothyroidism is a common complication when radiotherapy is part of the treatment for head and neck tumours. This study aimed to show the incidence of hypothyroidism and possible risk factors in these patients. METHODS: Factors related to the population, tumour, treatment and occurrence of hypothyroidism were analysed in 241 patients diagnosed ...περισσότερα »
Cellular microRNAs Repress Vesicular Stomatitis Virus but Not Theiler's Virus Replication.
*Cellular microRNAs Repress Vesicular Stomatitis Virus but Not Theiler's Virus Replication.* Viruses. 2016;8(3) Authors: De Cock A, Michiels T Abstract Picornavirus' genomic RNA is a positive-stranded RNA sequence that also serves as a template for translation and replication. Cellular microRNAs were reported to interfere to different extents with the replication of specific picornaviruses, mostly acting as inhibitors. However, owing to the high error rate of their RNA-dependent RNA-polymerases, picornavirus quasi-species are expected to evolve rapidly in order to lose any detri... περισσότερα »
Prosthodontic Management of Xerostomic Patient: A Technical Modification.
*Prosthodontic Management of Xerostomic Patient: A Technical Modification.* Case Rep Dent. 2016;2016:8905891 Authors: Gurkar H, Venkatesh OY, Somashekar JM, Gowda MH, Dwivedi M, Ningthoujam I Abstract Xerostomia is often a contributing factor in both minor and serious health problems. It can affect nutrition and dental as well as psychological health. Common problems faced by such patients are glossitis, mucositis, angular cheilitis, dysgeusia, and difficulty in chewing and swallowing. One of the major problems associated with xerostomic patients is the poor tolerance and retenti...περισσότερα »
[Current Status and Effectiveness of Perioperative Oral Health Care Management for Lung Cancer and Esophageal Cancer Patients].
*[Current Status and Effectiveness of Perioperative Oral Health Care Management for Lung Cancer and Esophageal Cancer Patients].* Kyobu Geka. 2016 Jan;69(1):30-4 Authors: Nishino T, Takizawa H, Yoshida T, Inui T, Takasugi H, Matsumoto D, Kawakita N, Inoue S, Sakiyama S, Tangoku A, Azuma M, Yamamura Y Abstract The effectiveness of perioperative oral health care management to decrease the risk of postoperative pneumonia have been reported lately. Since 2014, we introduced perioperative oral health care management for lung cancer and esophageal cancer patients. We report current stat... περισσότερα »
How Natural Product Research has Contributed to Oral Care Product Development? A Critical View.
*How Natural Product Research has Contributed to Oral Care Product Development? A Critical View.* Pharm Res. 2016 Mar 14; Authors: Freires IA, Rosalen PL Abstract PURPOSES: Despite the high number of studies on the biological effects of natural products (NP) and molecules isolated therefrom, only a small part of them reach the clinical phase and become commercially available. In this perspective we make an analysis on how plant research has impacted oral health care over the last 15 years. METHODS: Sixteen major clinical trial registry databases across the globe were searched for...περισσότερα »
WDR82 Negatively Regulates Cellular Antiviral Response by Mediating TRAF3 Polyubiquitination in Multiple Cell Lines.
[image: http:--highwire.stanford.edu-icons-exter] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *WDR82 Negatively Regulates Cellular Antiviral Response by Mediating TRAF3 Polyubiquitination in Multiple Cell Lines.* J Immunol. 2015 Dec 1;195(11):5358-66 Authors: Zhu K, Wang X, Ju LG, Zhu Y, Yao J, Wang Y, Wu M, Li LY Abstract Upon virus infection, retinoic acid-inducible gene I-like receptors in host cells recognize viral RNA and activate type I IFN expression. Previously, we identified WD repeat domain (WDR) 5 as one positive regulator for pathway activation. In this stu... περισσότερα »
upper respiratory tract infection; +41 new citations
41 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2016/03/16 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1nNGNRQ via IFTTT
The influence of frequency-dependent hearing loss to unaided APHAB scores.
*The influence of frequency-dependent hearing loss to unaided APHAB scores.* Eur Arch Otorhinolaryngol. 2016 Mar 14; Authors: Löhler J, Akcicek B, Wollenberg B, Kappe T, Schlattmann P, Schönweiler R Abstract Hearing loss can be measured by pure-tone and speech audiometry. The subjective hearing impairment can be assessed using questionnaires. The APHAB determines this for four typical hearing situations. It has not been researched previously whether a particular frequency-specific hearing loss leads to a particular unaided APHAB score in one of the subscales or not. Clarification...περισσότερα »
Next-Generation Genotyping by Digital PCR to Detect and Quantify the BRAF V600E Mutation in Melanoma Biopsies.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Next-Generation Genotyping by Digital PCR to Detect and Quantify the BRAF V600E Mutation in Melanoma Biopsies.* J Mol Diagn. 2015 Jul;17(4):366-73 Authors: Lamy PJ, Castan F, Lozano N, Montélion C, Audran P, Bibeau F, Roques S, Montels F, Laberenne AC Abstract The detection of the BRAF V600E mutation in melanoma samples is used to select patients who should respond to BRAF inhibitors. Different techniques are routinely used to determine BRAF status in clinical samples. However, low tumor cellularity and tumor het... περισσότερα »
Clinical Activity of Ipilimumab in Acral Melanoma: A Retrospective Review.
[image: http:--highwire.stanford.edu-icons-exter] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Clinical Activity of Ipilimumab in Acral Melanoma: A Retrospective Review.* Oncologist. 2015 Jun;20(6):648-52 Authors: Johnson DB, Peng C, Abramson RG, Ye F, Zhao S, Wolchok JD, Sosman JA, Carvajal RD, Ariyan CE Abstract BACKGROUND: Ipilimumab improves overall survival (OS) in advanced melanoma. Acral melanoma is an uncommon clinical subtype of this disease associated with poor prognosis. The clinical activity of ipilimumab has not been well-defined in advanced acral melanoma... περισσότερα »
Toward Rare Blood Cell Preservation for RNA Sequencing.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Toward Rare Blood Cell Preservation for RNA Sequencing.* J Mol Diagn. 2015 Jul;17(4):352-9 Authors: Vickovic S, Ahmadian A, Lewensohn R, Lundeberg J Abstract Cancer is driven by various events leading to cell differentiation and disease progression. Molecular tools are powerful approaches for describing how and why these events occur. With the growing field of next-generation DNA sequencing, there is an increasing need for high-quality nucleic acids derived from human cells and tissues-a prerequisite for successfu... περισσότερα »
A Phase I Trial of Bortezomib and Sorafenib in Advanced Malignant Melanoma.
[image: http:--highwire.stanford.edu-icons-exter] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *A Phase I Trial of Bortezomib and Sorafenib in Advanced Malignant Melanoma.* Oncologist. 2015 Jun;20(6):617-8 Authors: Sullivan RJ, Ibrahim N, Lawrence DP, Aldridge J, Giobbie-Hurder A, Hodi FS, Flaherty KT, Conley C, Mier JW, Atkins MB, McDermott DF Abstract LESSONS LEARNED: This study is a rare example of effective doses of both targeted agents being both administered and tolerated.This combination should not be used in melanoma. BACKGROUND: Sorafenib and bortezomib affect ... περισσότερα »
Clinical Activity of Ipilimumab in Acral Melanoma: A Retrospective Review.
[image: http:--highwire.stanford.edu-icons-exter] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Clinical Activity of Ipilimumab in Acral Melanoma: A Retrospective Review.* Oncologist. 2015 Jun;20(6):648-52 Authors: Johnson DB, Peng C, Abramson RG, Ye F, Zhao S, Wolchok JD, Sosman JA, Carvajal RD, Ariyan CE Abstract BACKGROUND: Ipilimumab improves overall survival (OS) in advanced melanoma. Acral melanoma is an uncommon clinical subtype of this disease associated with poor prognosis. The clinical activity of ipilimumab has not been well-defined in advanced acral melanoma... περισσότερα »
Arytenoid cartilage chondroma.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Arytenoid cartilage chondroma.* Auris Nasus Larynx. 2015 Oct;42(5):428-30 Authors: Lee DH, Kim JH, Yoon TM, Lee JK, Lim SC Abstract Arytenoid chondroma is an extremely rare benign cartilaginous tumor. We report a case of a patient with arytenoid chondroma initially mimicking laryngopharyngeal reflux. Clinicians should consider the possibility of the arytenoid chondroma in the differential diagnosis of patients with vocal cord palsy, or arytenoid swelling caused by laryngopharyngeal reflux. PMID: 25960446 [PubMed ... περισσότερα »
Next-Generation Genotyping by Digital PCR to Detect and Quantify the BRAF V600E Mutation in Melanoma Biopsies.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Next-Generation Genotyping by Digital PCR to Detect and Quantify the BRAF V600E Mutation in Melanoma Biopsies.* J Mol Diagn. 2015 Jul;17(4):366-73 Authors: Lamy PJ, Castan F, Lozano N, Montélion C, Audran P, Bibeau F, Roques S, Montels F, Laberenne AC Abstract The detection of the BRAF V600E mutation in melanoma samples is used to select patients who should respond to BRAF inhibitors. Different techniques are routinely used to determine BRAF status in clinical samples. However, low tumor cellularity and tumor het... περισσότερα »
Sequence-based typing of HLA-A gene in 930 patients with nasopharyngeal carcinoma in Hunan province, southern China.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Sequence-based typing of HLA-A gene in 930 patients with nasopharyngeal carcinoma in Hunan province, southern China.* Tissue Antigens. 2015 Jul;86(1):15-20 Authors: Tian W, Zhu FM, Wang WY, Cai JH, Zhang W, Li LX, Liu KL, Jin HK, Wang F Abstract In this study, we typed 930 cases of nasopharyngeal carcinoma (NPC) and 1134 normal controls recruited from Hunan province, southern China for human leukocyte antigen-A (HLA-A) locus by sequencing exons 2-4. Very significant associations between HLA-A*02:07, HLA-A*11:01 a... περισσότερα »
Comparing Platforms for Messenger RNA Expression Profiling of Archival Formalin-Fixed, Paraffin-Embedded Tissues.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Comparing Platforms for Messenger RNA Expression Profiling of Archival Formalin-Fixed, Paraffin-Embedded Tissues.* J Mol Diagn. 2015 Jul;17(4):374-81 Authors: Tyekucheva S, Martin NE, Stack EC, Wei W, Vathipadiekal V, Waldron L, Fiorentino M, Lis RT, Stampfer MJ, Loda M, Parmigiani G, Mucci LA, Birrer M Abstract Archival formalin-fixed, paraffin-embedded (FFPE) tissue specimens represent a readily available but largely untapped resource for gene expression profiling-based biomarker discovery. Several technologies... περισσότερα »
[Primary neuroendocrine tumor of the kidney. A rarity].
[image: http:--production.springer.de-OnlineReso] Related Articles *[Primary neuroendocrine tumor of the kidney. A rarity].* Urologe A. 2015 Jun;54(6):844-8 Authors: Maletzki P, Diener PA, Bjasch D, Schmid HP, Gramann T Abstract This article presents a rare case of a primary neuroendocrine tumor (NET) of the kidney. Abdominal magnetic resonance imaging (MRI) was performed in a 56-year-old man during the follow-up of an adrenal adenoma. Incidentally a renal tumor at the upper pole of the left kidney was diagnosed and was suspected of being a renal cell carcinoma. After partial neph... περισσότερα »
Identification and Validation of Differential Phosphorylation Sites of the Nuclear FOXL2 Protein as Potential Novel Biomarkers for Adult-Type Granulosa Cell Tumors.
[image: http:--pubs.acs.org-images-pubmed-acspub] Related Articles *Identification and Validation of Differential Phosphorylation Sites of the Nuclear FOXL2 Protein as Potential Novel Biomarkers for Adult-Type Granulosa Cell Tumors.* J Proteome Res. 2015 Jun 5;14(6):2446-56 Authors: Suh DS, Oh HK, Kim JH, Park S, Shin E, Lee K, Kim YH, Bae J Abstract Granulosa cell tumor (GCT) is a rare form of ovarian cancer classified as a sex cord-stromal tumor. The c.402C→G missense mutation in the FOXL2 gene that changes cysteine 134 to tryptophan (C134W) is found in more than 97% of adult-t... περισσότερα »
Angiogenesis inhibitor; +16 new citations
16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *Angiogenesis inhibitor* These pubmed results were generated on 2016/03/16 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1UyCeb3 via IFTTT
Sarcopenia and Hearing Loss in Older Koreans: Findings from the Korea National Health and Nutrition Examination Survey (KNHANES) 2010.
*Sarcopenia and Hearing Loss in Older Koreans: Findings from the Korea National Health and Nutrition Examination Survey (KNHANES) 2010.* PLoS One. 2016;11(3):e0150281 Authors: Lee J, Han K, Song JJ, Im GJ, Chae SW Abstract Age-related hearing impairment (ARHI) is becoming a more significant issue as geriatric population increases. Sarcopenia in older people is known to have a diverse health problem in various circumstances in recent studies. We assessed whether the decrease in muscle mass is related to ARHI. We used the 2010 data of the Korea National Health and Nutrition Examinat... περισσότερα »
Identification and Characterization of msf, a Novel Virulence Factor in Haemophilus influenzae.
*Identification and Characterization of msf, a Novel Virulence Factor in Haemophilus influenzae.* PLoS One. 2016;11(3):e0149891 Authors: Kress-Bennett JM, Hiller NL, Eutsey RA, Powell E, Longwell MJ, Hillman T, Blackwell T, Byers B, Mell JC, Post JC, Hu FZ, Ehrlich GD, Janto BA Abstract Haemophilus influenzae is an opportunistic pathogen. The emergence of virulent, non-typeable strains (NTHi) emphasizes the importance of developing new interventional targets. We screened the NTHi supragenome for genes encoding surface-exposed proteins suggestive of immune evasion, identifying a ... περισσότερα »
Previous tonsillectomy modifies odds of tonsil and base of tongue cancer.
*Previous tonsillectomy modifies odds of tonsil and base of tongue cancer.* Br J Cancer. 2016 Mar 15; Authors: Zevallos JP, Mazul AL, Rodriguez N, Weissler MC, Brennan P, Anantharaman D, Abedi-Ardekani B, Neil Hayes D, Olshan AF Abstract BACKGROUND: Tonsillectomy is a commonly performed surgical procedure that involves removal of the palatine tonsils. The purpose of this study is to examine the association between previous tonsillectomy and odds of oropharyngeal squamous cell carcinoma (OPSCC) in a large population-based case-control study. We hypothesise that previous tonsillecto... περισσότερα »
Epidemiology of asthma.
*Epidemiology of asthma.* Curr Opin Otolaryngol Head Neck Surg. 2016 Mar 14; Authors: Loftus PA, Wise SK Abstract PURPOSE OF REVIEW: This article reports the findings of recently published research articles and Centers for Disease Control (CDC) data on the epidemiology of asthma. Numerous otolaryngologic diseases are associated with asthma, such as allergic rhinitis, chronic rhinosinusitis, and obstructive sleep apnea. In addition, asthma causes a significant health burden and its prevalence is increasing. RECENT FINDINGS: Currently, 8.4% of persons in the United States have asth...περισσότερα »
Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study.
*Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study.* Biomed Res Int. 2016;2016:7319843 Authors: Zhang Y, Feng Y, Ming X, Deng J Abstract A novel treatment modality termed energy modulated photon radiotherapy (EMXRT) was investigated. The first step of EMXRT was to determine beam energy for each gantry angle/anatomy configuration from a pool of photon energy beams (2 to 10 MV) with a newly developed energy selector. An inverse planning system using gradient search algorithm was then employed to optimize photon beam intensity of various beam energies based on pr... περισσότερα »
Endoscopic Resection of Giant Ethmoid Osteomas with the Assistance of an Image-guidance System.
*Endoscopic Resection of Giant Ethmoid Osteomas with the Assistance of an Image-guidance System.* Anticancer Res. 2016 Mar;36(3):1325-30 Authors: Wang Y, Li D, Jiang A, Zhang H, Sun Y, Liu Z, Song X Abstract AIM: To investigate the minimally invasive ablation of giant osteoma of the ethmoid sinuses endonasally with the assistance of an image-guidance system. PATIENTS AND METHODS: A retrospective analysis was carried out on 12 patients with osteomas of ethmoid sinuses treated by endoscopic surgery with the help of a navigation system from April 2005 to October 2013. RESULTS: Osteoma... περισσότερα »
Extent of Salvage Neck Dissection in Advanced Oro- and Hypopharyngeal Cancer.
*Extent of Salvage Neck Dissection in Advanced Oro- and Hypopharyngeal Cancer.* Anticancer Res. 2016 Mar;36(3):981-6 Authors: Hoch S, Bohne F, Franke N, Wilhelm T, Teymoortash A Abstract BACKGROUND/AIM: Primary radiochemotherapy (RCT) is becoming increasingly important in patients with oro- and hypopharyngeal cancer. However, debate exists on the extent of salvage neck dissection (ND) in those patients. The purpose of the present study was to evaluate the regional control after salvage ND. PATIENTS AND METHODS: Clinical, histological and radiological data, results of 51 patients ... περισσότερα »
Split-Course Accelerated Hypofractionated Radiotherapy (SCAHRT): A Safe and Effective Option for Head and Neck Cancer in the Elderly or Infirm.
*Split-Course Accelerated Hypofractionated Radiotherapy (SCAHRT): A Safe and Effective Option for Head and Neck Cancer in the Elderly or Infirm.* Anticancer Res. 2016 Mar;36(3):933-9 Authors: Bledsoe TJ, Noble AR, Reddy CA, Burkey BB, Greskovich JF, Nwizu T, Adelstein DJ, Saxton JP, Koyfman SA Abstract BACKGROUND: Achieving locoregional control in high-risk patients with head and neck cancer who are poor candidates for standard continuous-course (chemo) radiotherapy due to advanced age, comorbidities, or very advanced disease is challenging. At our Institution, we have significant...περισσότερα »
Tonsillectomy and incidence of oropharyngeal cancers.
*Tonsillectomy and incidence of oropharyngeal cancers.* Cancer Epidemiol Biomarkers Prev. 2016 Mar 14; Authors: Chaturvedi AK, Song H, Rosenberg PS, Ramqvist T, Anderson WF, Munck-Wikland E, Ye W, Dalianis T Abstract BACKGROUND: Rising incidence of oropharyngeal cancers in numerous countries since the 1970s has been attributed to increased oral HPV exposure. However, the contribution of coincidental declines in the surgical removal of the tonsils (tonsillectomy) is unknown. We quantified the association of tonsillectomy with risk of tonsillar, other oropharyngeal, and other head ... περισσότερα »
Neurocognitive factors in sensory restoration of early deafness: a connectome model.
*Neurocognitive factors in sensory restoration of early deafness: a connectome model.* Lancet Neurol. 2016 Mar 11; Authors: Kral A, Kronenberger WG, Pisoni DB, O'Donoghue GM Abstract Progress in biomedical technology (cochlear, vestibular, and retinal implants) has led to remarkable success in neurosensory restoration, particularly in the auditory system. However, outcomes vary considerably, even after accounting for comorbidity-for example, after cochlear implantation, some deaf children develop spoken language skills approaching those of their hearing peers, whereas other child... περισσότερα »
Outcomes review of modern hearing preservation technique in cochlear implant.
*Outcomes review of modern hearing preservation technique in cochlear implant.* Auris Nasus Larynx. 2016 Mar 11; Authors: Nguyen S, Cloutier F, Philippon D, Côté M, Bussières R, Backous DD Abstract INTRODUCTION: Preservation of residual hearing in cochlear implantation is a main concern for patients and otologists. New electrode arrays as well as development of minimally invasive technique have allowed the expansion of indication criteria for cochlear implantation. The loss of residual low-frequency hearing is thought to be the result of many factors. Opinions differ in regards w... περισσότερα »
Vocal-fold vibration of patients with Reinke's edema observed using high-speed digital imaging.
*Vocal-fold vibration of patients with Reinke's edema observed using high-speed digital imaging.* Auris Nasus Larynx. 2016 Mar 11; Authors: Watanabe T, Kaneko K, Sakaguchi K, Takahashi H Abstract OBJECTIVE: We aimed to assess the vocal-fold vibration of patients with moderate-to-severe Reinke's edema using high-speed digital imaging (HSDI) and videostroboscopy and to confirm HSDI usefulness in examining the vocal folds with Reinke's edema. METHODS: We examined the vocal folds of seven patients (six severe and one moderate; six females and one male; aged 55-74 years; mean 64.7 year... περισσότερα »
Outcomes of synchronous pulmonary nodules detected on computed tomography in head and neck cancer patients: 12-year retrospective review of a consecutive cohort.
*Outcomes of synchronous pulmonary nodules detected on computed tomography in head and neck cancer patients: 12-year retrospective review of a consecutive cohort.* J Laryngol Otol. 2016 Mar 15;:1-6 Authors: Zammit-Maempel I, Kurien R, Paleri V Abstract OBJECTIVE: To investigate the long-term outcomes of pulmonary nodules detected on chest computed tomography in a consecutive cohort of patients with newly diagnosed or recurrent head and neck squamous cell cancer staged between 2001 and 2003. RESULTS: The study included 222 patients, 148 patients with newly diagnosed head and neck ... περισσότερα »
Visual afference mediates head and trunk stability in vestibular hypofunction.
*Visual afference mediates head and trunk stability in vestibular hypofunction.* J Clin Neurosci. 2016 Mar 11; Authors: Wei SH, Chen PY, Chen HJ, Kao CL, Schubert MC Abstract Humans must maintain head and trunk stability while walking. The purpose of this study was to compare the kinematics of healthy controls and patients with vestibular hypofunction (VH) when walking and making head rotations of different frequencies in both light and dark conditions. We recruited eight individuals with VH and nine healthy control subjects to perform four tasks at their preferred gait speed, be... περισσότερα »
Temporomandibular joint involvement as a positive clinical prognostic factor in necrotising external otitis.
*Temporomandibular joint involvement as a positive clinical prognostic factor in necrotising external otitis.* J Laryngol Otol. 2016 Mar 15;:1-5 Authors: Yeheskeli E, Eta RA, Gavriel H, Kleid S, Eviatar E Abstract OBJECTIVE: Necrotising otitis externa is associated with high morbidity and mortality rates. This study investigated whether temporomandibular joint involvement had any prognostic effect on the course of necrotising otitis externa in patients who had undergone hyperbaric oxygen therapy after failed medical and sometimes surgical therapy. METHODS: A retrospective case ser... περισσότερα »
Induction chemotherapy in head and neck squamous cell carcinoma of the paranasal sinus and nasal cavity: a role in organ preservation.
*Induction chemotherapy in head and neck squamous cell carcinoma of the paranasal sinus and nasal cavity: a role in organ preservation.* Korean J Intern Med. 2016 Mar 15; Authors: Ock CY, Keam B, Kim TM, Han DH, Won TB, Lee SH, Hah JH, Kwon TK, Kim DW, Kim DY, Rhee CS, Wu HG, Sung MW, Heo DS Abstract Background/Aims: The role of induction chemotherapy (IC) for eyeball preservation has not been established in head and neck squamous cell carcinoma (HNSCC) of the paranasal sinus and nasal cavity (PNSNC). Periorbital involvement frequently leads to eyeball exenteration with a margin ... περισσότερα »
Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.
*Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.* Clin Exp Otorhinolaryngol. 2016 Mar;9(1):80-4 Authors: Santos RS, Andrade MF, Alves Fde A, Kowalski LP, Perez DE Abstract OBJECTIVES: Metastasis of melanoma to the head and neck mucosa is a very unusual condition. The aim of this study was to report four cases of patients with metastatic melanoma in the head and neck mucosa treated at a single institution. METHODS: Clinical data were obtained from the medical records. All cases were histologically reviewed to confirm the diagnosis, and immunohistochemical ... περισσότερα »
Metastatic Lymph Node Ratio of Central Neck Compartment Has Predictive Values for Locoregional Recurrence in Papillary Thyroid Microcarcinoma.
*Metastatic Lymph Node Ratio of Central Neck Compartment Has Predictive Values for Locoregional Recurrence in Papillary Thyroid Microcarcinoma.* Clin Exp Otorhinolaryngol. 2016 Mar;9(1):75-9 Authors: Choi SY, Cho JK, Moon JH, Son YI Abstract OBJECTIVES: This study aimed to evaluate the significance of metastatic lymph node ratio (the ratio between the metastatic lymph node and the harvested lymph nodes; MLNR) in the central neck for the prediction of locoregional recurrence in patients with papillary thyroid microcarcinoma. METHODS: After reviewing medical records of papillary thyr...περισσότερα »
Histological Effect of Basic Fibroblast Growth Factor on Chronic Vocal Fold Scarring in a Rat Model.
*Histological Effect of Basic Fibroblast Growth Factor on Chronic Vocal Fold Scarring in a Rat Model.* Clin Exp Otorhinolaryngol. 2016 Mar;9(1):56-61 Authors: Tateya I, Tateya T, Sohn JH, Bless DM Abstract OBJECTIVES: Vocal fold scarring is one of the most challenging laryngeal disorders to treat and there are currently no consistently effective treatments available. Our previous studies have shown the therapeutic potential of basic fibroblast growth factor (bFGF) for vocal fold scarring. However, the histological effects of bFGF on scarred vocal fold have not been elucidated. Th...περισσότερα »
Improvement of Pulmonary Functions Following Septoplasty: How Are Lower Airways Affected?
*Improvement of Pulmonary Functions Following Septoplasty: How Are Lower Airways Affected?* Clin Exp Otorhinolaryngol. 2016 Mar;9(1):51-5 Authors: Tuzuner A, Bilgin G, Demirci S, Yuce GD, Acikgoz C, Samim EE Abstract OBJECTIVES: Nasal septal deviation is a frequent cause of increased nasal airway resistance. A narrow nasal airway would result in a decreased airflow into the lungs. The aim of the present study was to evaluate the alterations of the pulmonary functions following septoplasty using spirometry and 6 minutes walking test (6mWT). And reveal the correlation of symptom sc...περισσότερα »
[The specific clinical features of acute sensorineural loss of hearing associated with vertigo].
*[The specific clinical features of acute sensorineural loss of hearing associated with vertigo].* Vestn Otorinolaringol. 2016;81(1):8-12 Authors: Pal'chun VT, Guseva AL, Levina YV, Chistov SD Abstract The objective of the present study was to estimate the prevalence of vertigo and to determine the type of the lesion of the vestibular analyzer in the patients presenting with acute sensorineural loss of hearing (ASNLH). The secondary objective wasto evaluate the possibility of the restoration of the auditory thresholds. The results of the examination and treatment of 94 patients s... περισσότερα »
Silicone impression material foreign body in the middle ear: Two case reports and literature review.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Silicone impression material foreign body in the middle ear: Two case reports and literature review.* Auris Nasus Larynx. 2015 Oct;42(5):419-23 Authors: Suzuki N, Okamura K, Yano T, Moteki H, Kitoh R, Takumi Y, Usami S Abstract We report two cases of impression material foreign body in the middle ear. The first case had been affected with chronic otitis media. The silicone flowed into the middle ear through a tympanic membrane perforation during the process of making an ear mold. About 4 years and 8 months after, t... περισσότερα »
Endonasal Endoscopic Transsphenoidal Approach to Lesions of the Sellar Region in Pediatric Patients.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Endonasal Endoscopic Transsphenoidal Approach to Lesions of the Sellar Region in Pediatric Patients.* J Craniofac Surg. 2015 Sep;26(6):1818-22 Authors: Zhan R, Xin T, Li X, Li W, Li X Abstract OBJECTIVE: Endoscopic endonasal (transnasal) transsphenoidal approach (EETA) for management of sellar lesions has gained popularity as a reliable and atraumatic method. Most reported studies of EETA have focused on surgical outcome in adult patients; and there are few reports to describ... περισσότερα »
Visual afference mediates head and trunk stability in vestibular hypofunction.
*Visual afference mediates head and trunk stability in vestibular hypofunction.* J Clin Neurosci. 2016 Mar 11; Authors: Wei SH, Chen PY, Chen HJ, Kao CL, Schubert MC Abstract Humans must maintain head and trunk stability while walking. The purpose of this study was to compare the kinematics of healthy controls and patients with vestibular hypofunction (VH) when walking and making head rotations of different frequencies in both light and dark conditions. We recruited eight individuals with VH and nine healthy control subjects to perform four tasks at their preferred gait speed, be... περισσότερα »
Aetiology and pathology of otitis media with effusion in adult life.
*Aetiology and pathology of otitis media with effusion in adult life.* J Laryngol Otol. 2016 Mar 15;:1-7 Authors: Mills R, Hathorn I Abstract OBJECTIVES: To gather and analyse information concerning the aetiology and pathology of otitis media with effusion in adults. METHOD: A review of the English language literature from 1970 to the present was conducted. RESULTS: The available evidence suggests that otitis media with effusion in adult life is best viewed as a syndrome with a number of causes, including: infiltration of the eustachian tube by nasopharyngeal carcinoma and other l... περισσότερα »
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Outcomes of synchronous pulmonary nodules detected on computed tomography in head and neck cancer patients: 12-year retrospective review of a consecutive cohort.
*Outcomes of synchronous pulmonary nodules detected on computed tomography in head and neck cancer patients: 12-year retrospective review of a consecutive cohort.* J Laryngol Otol. 2016 Mar 15;:1-6 Authors: Zammit-Maempel I, Kurien R, Paleri V Abstract OBJECTIVE: To investigate the long-term outcomes of pulmonary nodules detected on chest computed tomography in a consecutive cohort of patients with newly diagnosed or recurrent head and neck squamous cell cancer staged between 2001 and 2003. RESULTS: The study included 222 patients, 148 patients with newly diagnosed head and neck ... περισσότερα »
Temporomandibular joint involvement as a positive clinical prognostic factor in necrotising external otitis.
*Temporomandibular joint involvement as a positive clinical prognostic factor in necrotising external otitis.* J Laryngol Otol. 2016 Mar 15;:1-5 Authors: Yeheskeli E, Eta RA, Gavriel H, Kleid S, Eviatar E Abstract OBJECTIVE: Necrotising otitis externa is associated with high morbidity and mortality rates. This study investigated whether temporomandibular joint involvement had any prognostic effect on the course of necrotising otitis externa in patients who had undergone hyperbaric oxygen therapy after failed medical and sometimes surgical therapy. METHODS: A retrospective case ser... περισσότερα »
Hypothyroidism in patients treated with radiotherapy for head and neck carcinoma: standardised long-term follow-up study.
*Hypothyroidism in patients treated with radiotherapy for head and neck carcinoma: standardised long-term follow-up study.* J Laryngol Otol. 2016 Mar 15;:1-4 Authors: Alba JR, Basterra J, Ferrer JC, Santonja F, Zapater E Abstract OBJECTIVE: Hypothyroidism is a common complication when radiotherapy is part of the treatment for head and neck tumours. This study aimed to show the incidence of hypothyroidism and possible risk factors in these patients. METHODS: Factors related to the population, tumour, treatment and occurrence of hypothyroidism were analysed in 241 patients diagnosed ...περισσότερα »
The influence of frequency-dependent hearing loss to unaided APHAB scores.
*The influence of frequency-dependent hearing loss to unaided APHAB scores.* Eur Arch Otorhinolaryngol. 2016 Mar 14; Authors: Löhler J, Akcicek B, Wollenberg B, Kappe T, Schlattmann P, Schönweiler R Abstract Hearing loss can be measured by pure-tone and speech audiometry. The subjective hearing impairment can be assessed using questionnaires. The APHAB determines this for four typical hearing situations. It has not been researched previously whether a particular frequency-specific hearing loss leads to a particular unaided APHAB score in one of the subscales or not. Clarification...περισσότερα »
Prevalence and pattern of humoral immunodeficiency in chronic refractory sinusitis.
*Prevalence and pattern of humoral immunodeficiency in chronic refractory sinusitis.* Eur Arch Otorhinolaryngol. 2016 Mar 14; Authors: Odat H, Alqudah M Abstract The purpose of this study is to readdress the issue of primary humoral immunodeficiency frequency and pattern in medically resistant chronic rhinosinusitis (CRS) based on the new guidelines for CRS diagnosis and management. Two hundred and fifty-seven consecutive patients with refractory CRS were included in this study. The results of their IgA, IgM, IgG, and IgG subclasses were analyzed and compared with 75 age- and ge...περισσότερα »
Sex and the PASI: patients affected by a mild form of psoriasis are more predisposed to have a more severe form of erectile dysfunction
Abstract Background Psoriasis is a multi-systemic disease involving the skin and joints, but it is also characterized by endothelial dysfunction, which may cause sexual impotence and erectile dysfunction (ED), an embarrassing disease frequently neglected by dermatologists. Objective The principal objective was assessing the relationship between the severity of psoriasis and the severity of ED. We also investigated whether severity of psoriasis was related to International Index of Erectile Function-5 (IIEF-5) score, whether genital lesions worsened the IIEF-5 score, whether ED w... περισσότερα »
Cordoniform morphea. a clinicopathologic study of two cases presenting with the rope sign
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Next-Generation Genotyping by Digital PCR to Detect and Quantify the BRAF V600E Mutation in Melanoma Biopsies.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Next-Generation Genotyping by Digital PCR to Detect and Quantify the BRAF V600E Mutation in Melanoma Biopsies.* J Mol Diagn. 2015 Jul;17(4):366-73 Authors: Lamy PJ, Castan F, Lozano N, Montélion C, Audran P, Bibeau F, Roques S, Montels F, Laberenne AC Abstract The detection of the BRAF V600E mutation in melanoma samples is used to select patients who should respond to BRAF inhibitors. Different techniques are routinely used to determine BRAF status in clinical samples. However, low tumor cellularity and tumor het... περισσότερα »
Clinical Activity of Ipilimumab in Acral Melanoma: A Retrospective Review.
[image: http:--highwire.stanford.edu-icons-exter] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Clinical Activity of Ipilimumab in Acral Melanoma: A Retrospective Review.* Oncologist. 2015 Jun;20(6):648-52 Authors: Johnson DB, Peng C, Abramson RG, Ye F, Zhao S, Wolchok JD, Sosman JA, Carvajal RD, Ariyan CE Abstract BACKGROUND: Ipilimumab improves overall survival (OS) in advanced melanoma. Acral melanoma is an uncommon clinical subtype of this disease associated with poor prognosis. The clinical activity of ipilimumab has not been well-defined in advanced acral melanoma... περισσότερα »
The role of stereotactic radiosurgery in the treatment of intramedullary spinal cord neoplasms: a systematic literature review
Abstract Advances in imaging technology and microsurgical techniques have made microsurgical resection the treatment of choice in cases of symptomatic intramedullary tumors. The use of stereotactic radiosurgery (SRS) for spinal tumors is a recent development, and its application to intramedullary lesions is debated. We conducted a literature search through PubMed's MeSH system, compiling information regarding intramedullary neoplasms treated by SRS. We compiled histology, tumor location and size, treatment modality, radiation dose, fractionation, radiation-induced complications, f...περισσότερα »
Aperius interspinous device for degenerative lumbar spinal stenosis: a review
Abstract With an aging population, degenerative lumbar spinal stenosis (DLSS) leading to neurogenic intermittent claudication (NIC) is a growing problem. For patients suffering from this condition, interspinous process distraction devices (IPDs) offer an effective and cheap alternative to conservative or decompressive surgery. Aperius is one such device that has been gaining popularity for its percutaneous insertion under local anesthetic, short operative time, and low risk of complications. The main objective of this review was to carry out a comprehensive search of the literatur... περισσότερα »
Retromer-Mediated Protein Sorting and Vesicular Trafficking
[image: S16738527.gif] Publication date: Available online 15 March 2016 *Source:*Journal of Genetics and Genomics Author(s): Jia-Jia Liu Retromer is an evolutionarily conserved multimeric protein complex that mediates intracellular transport of various vesicular cargoes and functions in a wide variety of cellular processes including polarized trafficking, developmental signaling and lysosome biogenesis. Through its interaction with the Rab GTPases and their effectors, membrane lipids, molecular motors, the endocytic machinery and actin nucleation promoting factors, retromer regulate...περισσότερα »
Clinical Activity of Ipilimumab in Acral Melanoma: A Retrospective Review.
[image: http:--highwire.stanford.edu-icons-exter] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Clinical Activity of Ipilimumab in Acral Melanoma: A Retrospective Review.* Oncologist. 2015 Jun;20(6):648-52 Authors: Johnson DB, Peng C, Abramson RG, Ye F, Zhao S, Wolchok JD, Sosman JA, Carvajal RD, Ariyan CE Abstract BACKGROUND: Ipilimumab improves overall survival (OS) in advanced melanoma. Acral melanoma is an uncommon clinical subtype of this disease associated with poor prognosis. The clinical activity of ipilimumab has not been well-defined in advanced acral melanoma... περισσότερα »
A Phase I Trial of Bortezomib and Sorafenib in Advanced Malignant Melanoma.
[image: http:--highwire.stanford.edu-icons-exter] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *A Phase I Trial of Bortezomib and Sorafenib in Advanced Malignant Melanoma.* Oncologist. 2015 Jun;20(6):617-8 Authors: Sullivan RJ, Ibrahim N, Lawrence DP, Aldridge J, Giobbie-Hurder A, Hodi FS, Flaherty KT, Conley C, Mier JW, Atkins MB, McDermott DF Abstract LESSONS LEARNED: This study is a rare example of effective doses of both targeted agents being both administered and tolerated.This combination should not be used in melanoma. BACKGROUND: Sorafenib and bortezomib affect ... περισσότερα »
Unusual presentation of a pancreatic cyst resulting from osteosarcoma metastasis.
[image: http:--http://ift.tt/1YyhL4R] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Unusual presentation of a pancreatic cyst resulting from osteosarcoma metastasis.* World J Gastroenterol. 2015 Jul 21;21(27):8452-7 Authors: Akpinar B, Obuch J, Fukami N, Pokharel SS Abstract Pancreatic metastases are uncommon. They have been reported in lung cancer, gastrointestinal malignancies, breast cancer, renal cell carcinoma, melanoma, lymphoma and sarcoma, and usually have solid morphology. Cystic metastasis to the pancreas is even more rare with few case reports in the literat... περισσότερα »
Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.
*Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.* Clin Exp Otorhinolaryngol. 2016 Mar;9(1):80-4 Authors: Santos RS, Andrade MF, Alves Fde A, Kowalski LP, Perez DE Abstract OBJECTIVES: Metastasis of melanoma to the head and neck mucosa is a very unusual condition. The aim of this study was to report four cases of patients with metastatic melanoma in the head and neck mucosa treated at a single institution. METHODS: Clinical data were obtained from the medical records. All cases were histologically reviewed to confirm the diagnosis, and immunohistochemical ... περισσότερα »
Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.
*Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.* Clin Exp Otorhinolaryngol. 2016 Mar;9(1):80-4 Authors: Santos RS, Andrade MF, Alves Fde A, Kowalski LP, Perez DE Abstract OBJECTIVES: Metastasis of melanoma to the head and neck mucosa is a very unusual condition. The aim of this study was to report four cases of patients with metastatic melanoma in the head and neck mucosa treated at a single institution. METHODS: Clinical data were obtained from the medical records. All cases were histologically reviewed to confirm the diagnosis, and immunohistochemical ... περισσότερα »
A Phase I Trial of Bortezomib and Sorafenib in Advanced Malignant Melanoma.
[image: http:--highwire.stanford.edu-icons-exter] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *A Phase I Trial of Bortezomib and Sorafenib in Advanced Malignant Melanoma.* Oncologist. 2015 Jun;20(6):617-8 Authors: Sullivan RJ, Ibrahim N, Lawrence DP, Aldridge J, Giobbie-Hurder A, Hodi FS, Flaherty KT, Conley C, Mier JW, Atkins MB, McDermott DF Abstract LESSONS LEARNED: This study is a rare example of effective doses of both targeted agents being both administered and tolerated.This combination should not be used in melanoma. BACKGROUND: Sorafenib and bortezomib affect ... περισσότερα »
Unusual presentation of a pancreatic cyst resulting from osteosarcoma metastasis.
[image: http:--http://ift.tt/1YyhL4R] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Unusual presentation of a pancreatic cyst resulting from osteosarcoma metastasis.* World J Gastroenterol. 2015 Jul 21;21(27):8452-7 Authors: Akpinar B, Obuch J, Fukami N, Pokharel SS Abstract Pancreatic metastases are uncommon. They have been reported in lung cancer, gastrointestinal malignancies, breast cancer, renal cell carcinoma, melanoma, lymphoma and sarcoma, and usually have solid morphology. Cystic metastasis to the pancreas is even more rare with few case reports in the literat... περισσότερα »
Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.
*Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.* Clin Exp Otorhinolaryngol. 2016 Mar;9(1):80-4 Authors: Santos RS, Andrade MF, Alves Fde A, Kowalski LP, Perez DE Abstract OBJECTIVES: Metastasis of melanoma to the head and neck mucosa is a very unusual condition. The aim of this study was to report four cases of patients with metastatic melanoma in the head and neck mucosa treated at a single institution. METHODS: Clinical data were obtained from the medical records. All cases were histologically reviewed to confirm the diagnosis, and immunohistochemical ... περισσότερα »
Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.
*Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.* Clin Exp Otorhinolaryngol. 2016 Mar;9(1):80-4 Authors: Santos RS, Andrade MF, Alves Fde A, Kowalski LP, Perez DE Abstract OBJECTIVES: Metastasis of melanoma to the head and neck mucosa is a very unusual condition. The aim of this study was to report four cases of patients with metastatic melanoma in the head and neck mucosa treated at a single institution. METHODS: Clinical data were obtained from the medical records. All cases were histologically reviewed to confirm the diagnosis, and immunohistochemical ... περισσότερα »
From structures to functions: insights into exosomes as promising drug delivery vehicles.
*From structures to functions: insights into exosomes as promising drug delivery vehicles.* Biomater Sci. 2016 Mar 15; Authors: Ren J, He W, Zheng L, Duan H Abstract Exosomes are small membrane vesicles secreted by most cell types, and appear ubiquitously in cell culture supernatants and body fluids. Increasing evidence supports that exosomes play important roles in intercellular communication, both locally and systemically, by transporting their contents such as proteins, lipids and RNAs between cells. Of particular interest for controlled drug delivery is that cell-derived exo...περισσότερα »
Diminished Quality of Life and Increased Brain Functional Connectivity in Patients with Hypothyroidism after Total Thyroidectomy.
*Diminished Quality of Life and Increased Brain Functional Connectivity in Patients with Hypothyroidism after Total Thyroidectomy.* Thyroid. 2016 Mar 15; Authors: Shin YW, Choi YM, Kim HS, Kim DJ, Jo HJ, O'Donnell BF, Jang EK, Kim TY, Shong Y, Hong JP, Kim WB Abstract BACKGROUND: Acute hypothyroidism induced by thyroid hormone withdrawal (THW) in patients with thyroid cancer after total thyroidectomy can affect mood and quality of life (QoL). While loss or dysregulation of thyroid hormone (TH) has these well-known behavioral consequences, the effects of TH alterations on brain fu... περισσότερα »
Genodermatosis Affecting the Skin and Mucosa of the Head and Neck: Clinicopathologic, Genetic, and Molecular Aspect-PTEN-Hamartoma Tumor Syndrome/Cowden Syndrome.
*Genodermatosis Affecting the Skin and Mucosa of the Head and Neck: Clinicopathologic, Genetic, and Molecular Aspect-PTEN-Hamartoma Tumor Syndrome/Cowden Syndrome.* Head Neck Pathol. 2016 Mar 14; Authors: Nosé V Abstract PTEN hamartoma tumor syndrome refers to a spectrum of disorders caused by mutations in the phosphatase and tensin homolog (PTEN) gene. Cowden syndrome, the principal PTEN-related disorder is characterized by multiple neoplasms and hamartomas, mucosal papillomatosis, and skin lesions, trichilemmomas. Trichilemmomas and mucocutaneous papillomatous papules are one ... περισσότερα »
Hypothyroidism in patients treated with radiotherapy for head and neck carcinoma: standardised long-term follow-up study.
*Hypothyroidism in patients treated with radiotherapy for head and neck carcinoma: standardised long-term follow-up study.* J Laryngol Otol. 2016 Mar 15;:1-4 Authors: Alba JR, Basterra J, Ferrer JC, Santonja F, Zapater E Abstract OBJECTIVE: Hypothyroidism is a common complication when radiotherapy is part of the treatment for head and neck tumours. This study aimed to show the incidence of hypothyroidism and possible risk factors in these patients. METHODS: Factors related to the population, tumour, treatment and occurrence of hypothyroidism were analysed in 241 patients diagnosed ...περισσότερα »
Effect of ALDH1 on prognosis and chemoresistance by breast cancer subtype.
*Effect of ALDH1 on prognosis and chemoresistance by breast cancer subtype.* Breast Cancer Res Treat. 2016 Mar 14; Authors: Kida K, Ishikawa T, Yamada A, Shimada K, Narui K, Sugae S, Shimizu D, Tanabe M, Sasaki T, Ichikawa Y, Endo I Abstract Aldehyde dehydrogenase 1 (ALDH1) has been identified as a breast cancer stem cell marker, but its value as a predictor of prognosis and chemoresistance is controversial. This study investigated the effect of ALDH1 on prognosis and chemoresponse by breast cancer subtype. We immunohistochemically analyzed 653 invasive breast cancer specimens and... περισσότερα »
[INCIDENCE AND SURGICAL IMPORTANCE OF PYRAMIDAL LOBE AND TUBERCLE OF THE THYROID GLAND: A PROSPECTIVE STUDY].
*[INCIDENCE AND SURGICAL IMPORTANCE OF PYRAMIDAL LOBE AND TUBERCLE OF THE THYROID GLAND: A PROSPECTIVE STUDY].* Lijec Vjesn. 2015 Nov-Dec;137(11-12):357-60 Authors: Kovacić M, Kovadcić I Abstract The pyramidal lobe and tubercles are common anatomic variations of the thyroid gland, and their frequency is highly represented. While pyramidal lobe requires additional seriousness in identifying and its removal, especially in patients with hyperthyroidism and thyroid cancer, the presence of tubercles is desirable. Tubercle is covered by recurrent laryngeal nerve and directs the surgeon... περισσότερα »
Integrin αvβ3 as a Promising Target to Image Neoangiogenesis Using In-House Generator-Produced Positron Emitter (68)Ga-Labeled DOTA-Arginine-Glycine-Aspartic Acid (RGD) Ligand.
Related Articles *Integrin αvβ3 as a Promising Target to Image Neoangiogenesis Using In-House Generator-Produced Positron Emitter (68)Ga-Labeled DOTA-Arginine-Glycine-Aspartic Acid (RGD) Ligand.* Cancer Biother Radiopharm. 2015 Jun;30(5):217-24 Authors: Vatsa R, Bhusari P, Kumar S, Chakraborty S, Dash A, Singh G, Dhawan DK, Shukla J, Mittal BR Abstract For the growth and spread of a tumor beyond 2 mm, angiogenesis plays a crucial role, and association of various integrins with angiogenesis is evidential. The aim of the study was radiolabeling of DOTA-chelated RGD (arginine-glyci... περισσότερα »
Lymphatic-targeted therapy following neoadjuvant chemotherapy: a promising strategy for lymph node-positive breast cancer treatment.
Related Articles *Lymphatic-targeted therapy following neoadjuvant chemotherapy: a promising strategy for lymph node-positive breast cancer treatment.* Med Oncol. 2015 Jul;32(7):184 Authors: Chen J, Yao Q, Wang H, Wang B, Zhang J, Wang T, Lv Y, Han Z, Wang L Abstract Neoadjuvant chemotherapy has been increasingly used to downstage breast cancer prior to surgery recently. However, in some cases, it was observed that despite sufficient regression of primary tumors, the metastatic lymph nodes remained nonresponsive. In this study, we applied lymphatic-targeted strategy to evaluate i... περισσότερα »
Effect of sodium/iodide symporter (NIS)-mediated radioiodine therapy on estrogen receptor-negative breast cancer.
Related Articles *Effect of sodium/iodide symporter (NIS)-mediated radioiodine therapy on estrogen receptor-negative breast cancer.* Oncol Rep. 2015 Jul;34(1):59-66 Authors: Yao C, Pan Y, Li Y, Xu X, Lin Y, Wang W, Wang S Abstract Since the sodium/iodide symporter (NIS) stimulates the iodine uptake in normal lactating breast, our study aimed to study the effect of NIS-mediated radioiodide therapy on ER-negative breast cancers. A recombinant lentivirus plasmid encoding the human NIS (hNIS) gene and firefly luciferase (Fluc) was constructed. MDA-MB-231 cells were transfected with ... περισσότερα »
Evaluation of the Real-Q BRAF V600E Detection Assay in Fine-Needle Aspiration Samples of Thyroid Nodules.
Related Articles *Evaluation of the Real-Q BRAF V600E Detection Assay in Fine-Needle Aspiration Samples of Thyroid Nodules.* J Mol Diagn. 2015 Jul;17(4):431-7 Authors: Park KS, Oh YL, Ki CS, Kim JW Abstract Recently, several molecular assays for detecting the BRAF V600E mutation in fine-needle aspiration (FNA) specimens have been developed. Herein, we tested 294 consecutive FNA samples from patients with thyroid nodules with the Real-Q BRAF V600E detection assay (Real-Q). These results were compared with an allele-specific PCR-based kit using dual-priming oligonucleotides (AS-PC... περισσότερα »
Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling.
Related Articles *Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling.* Nat Commun. 2015;6:7048 Authors: Grøntved L, Waterfall JJ, Kim DW, Baek S, Sung MH, Zhao L, Park JW, Nielsen R, Walker RL, Zhu YJ, Meltzer PS, Hager GL, Cheng SY Abstract A bimodal switch model is widely used to describe transcriptional regulation by the thyroid hormone receptor (TR). In this model, the unliganded TR forms stable, chromatin-bound complexes with transcriptional co-repressors to repress transcription. Binding of horm... περισσότερα »
A Phase I Trial of Bortezomib and Sorafenib in Advanced Malignant Melanoma.
[image: http:--highwire.stanford.edu-icons-exter] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *A Phase I Trial of Bortezomib and Sorafenib in Advanced Malignant Melanoma.* Oncologist. 2015 Jun;20(6):617-8 Authors: Sullivan RJ, Ibrahim N, Lawrence DP, Aldridge J, Giobbie-Hurder A, Hodi FS, Flaherty KT, Conley C, Mier JW, Atkins MB, McDermott DF Abstract LESSONS LEARNED: This study is a rare example of effective doses of both targeted agents being both administered and tolerated.This combination should not be used in melanoma. BACKGROUND: Sorafenib and bortezomib affect ... περισσότερα »
Unusual presentation of a pancreatic cyst resulting from osteosarcoma metastasis.
[image: http:--http://ift.tt/1YyhL4R] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Unusual presentation of a pancreatic cyst resulting from osteosarcoma metastasis.* World J Gastroenterol. 2015 Jul 21;21(27):8452-7 Authors: Akpinar B, Obuch J, Fukami N, Pokharel SS Abstract Pancreatic metastases are uncommon. They have been reported in lung cancer, gastrointestinal malignancies, breast cancer, renal cell carcinoma, melanoma, lymphoma and sarcoma, and usually have solid morphology. Cystic metastasis to the pancreas is even more rare with few case reports in the literat... περισσότερα »
Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.
*Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.* Clin Exp Otorhinolaryngol. 2016 Mar;9(1):80-4 Authors: Santos RS, Andrade MF, Alves Fde A, Kowalski LP, Perez DE Abstract OBJECTIVES: Metastasis of melanoma to the head and neck mucosa is a very unusual condition. The aim of this study was to report four cases of patients with metastatic melanoma in the head and neck mucosa treated at a single institution. METHODS: Clinical data were obtained from the medical records. All cases were histologically reviewed to confirm the diagnosis, and immunohistochemical ... περισσότερα »
Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.
*Metastases of Melanoma to Head and Neck Mucosa: A Report of Short Series.* Clin Exp Otorhinolaryngol. 2016 Mar;9(1):80-4 Authors: Santos RS, Andrade MF, Alves Fde A, Kowalski LP, Perez DE Abstract OBJECTIVES: Metastasis of melanoma to the head and neck mucosa is a very unusual condition. The aim of this study was to report four cases of patients with metastatic melanoma in the head and neck mucosa treated at a single institution. METHODS: Clinical data were obtained from the medical records. All cases were histologically reviewed to confirm the diagnosis, and immunohistochemical ... περισσότερα »
Development of a high-resolution melting analysis assay for rapid and high-throughput identification of clinically important dermatophyte species
Summary Accurate identification of dermatophyte species is important both for epidemiological studies and for implementing antifungal treatment strategies. Although nucleic acid amplification-based assays have several advantages over conventional mycological methods, a major disadvantage is their high cost. The aim of this study was to develop a rapid and accurate real-time PCR-based high-resolution melting (HRM) assay for differentiation of the most common dermatophyte species. The oligonucleotide primers were designed to amplify highly conserved regions of the dermatophyte riboso... περισσότερα »
Metastatic Lymph Node Ratio of Central Neck Compartment Has Predictive Values for Locoregional Recurrence in Papillary Thyroid Microcarcinoma.
*Metastatic Lymph Node Ratio of Central Neck Compartment Has Predictive Values for Locoregional Recurrence in Papillary Thyroid Microcarcinoma.* Clin Exp Otorhinolaryngol. 2016 Mar;9(1):75-9 Authors: Choi SY, Cho JK, Moon JH, Son YI Abstract OBJECTIVES: This study aimed to evaluate the significance of metastatic lymph node ratio (the ratio between the metastatic lymph node and the harvested lymph nodes; MLNR) in the central neck for the prediction of locoregional recurrence in patients with papillary thyroid microcarcinoma. METHODS: After reviewing medical records of papillary thyr...περισσότερα »
Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study.
*Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study.* Biomed Res Int. 2016;2016:7319843 Authors: Zhang Y, Feng Y, Ming X, Deng J Abstract A novel treatment modality termed energy modulated photon radiotherapy (EMXRT) was investigated. The first step of EMXRT was to determine beam energy for each gantry angle/anatomy configuration from a pool of photon energy beams (2 to 10 MV) with a newly developed energy selector. An inverse planning system using gradient search algorithm was then employed to optimize photon beam intensity of various beam energies based on pr... περισσότερα »
Hypothyroidism in patients treated with radiotherapy for head and neck carcinoma: standardised long-term follow-up study.
*Hypothyroidism in patients treated with radiotherapy for head and neck carcinoma: standardised long-term follow-up study.* J Laryngol Otol. 2016 Mar 15;:1-4 Authors: Alba JR, Basterra J, Ferrer JC, Santonja F, Zapater E Abstract OBJECTIVE: Hypothyroidism is a common complication when radiotherapy is part of the treatment for head and neck tumours. This study aimed to show the incidence of hypothyroidism and possible risk factors in these patients. METHODS: Factors related to the population, tumour, treatment and occurrence of hypothyroidism were analysed in 241 patients diagnosed ...περισσότερα »
From structures to functions: insights into exosomes as promising drug delivery vehicles.
*From structures to functions: insights into exosomes as promising drug delivery vehicles.* Biomater Sci. 2016 Mar 15; Authors: Ren J, He W, Zheng L, Duan H Abstract Exosomes are small membrane vesicles secreted by most cell types, and appear ubiquitously in cell culture supernatants and body fluids. Increasing evidence supports that exosomes play important roles in intercellular communication, both locally and systemically, by transporting their contents such as proteins, lipids and RNAs between cells. Of particular interest for controlled drug delivery is that cell-derived exo...περισσότερα »
Diminished Quality of Life and Increased Brain Functional Connectivity in Patients with Hypothyroidism after Total Thyroidectomy.
*Diminished Quality of Life and Increased Brain Functional Connectivity in Patients with Hypothyroidism after Total Thyroidectomy.* Thyroid. 2016 Mar 15; Authors: Shin YW, Choi YM, Kim HS, Kim DJ, Jo HJ, O'Donnell BF, Jang EK, Kim TY, Shong Y, Hong JP, Kim WB Abstract BACKGROUND: Acute hypothyroidism induced by thyroid hormone withdrawal (THW) in patients with thyroid cancer after total thyroidectomy can affect mood and quality of life (QoL). While loss or dysregulation of thyroid hormone (TH) has these well-known behavioral consequences, the effects of TH alterations on brain fu... περισσότερα »
