Misstrauen die Praktiker beim Lungenrundherd den Leitlinien?
Dilemma beim Lungenscreening Trotz Fortschritten in Bildgebung und Verfügbarkeit nicht operativer Biopsiemethoden wird in der Praxis beim Lungenrundherd nach wie vor oft invasiv diagnostiziert und unnötig chirurgisch entfernt, wie eine Beobachtungsstudie ergab. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TVBgpL via IFTTT
Typ-1-Diabetes: Wenn die Wahrnehmung für Hypoglykämie gestört ist
Assoziation mit Glukosevariabilität Schwere Hypoglykämien bei älteren Typ-1-Diabetikern sind mit Hypoglykämie-Wahrnehmungsstörungen und einer höheren Glukosevariabilität assoziiert. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qufGgn via IFTTT
Suppression of invasion and metastasis in aggressive salivary cancer cells through targeted inhibition of ID1 gene expression
The spread of aggressive cancer is a multistep process that involves many genetic and epigenetic alterations, and is a devastating and ultimately fatal condition. A majority of available therapeutic strategies for cancer patients are nonspecific, have significant associated toxicities, and do not produce durable responses [1]. A critical barrier in the treatment of aggressive cancer… Continue reading Suppression of invasion and metastasis in aggressive salivary cancer cells through targeted inhibition of ID1 gene expression
Overcoming treatment resistance in cancer: current understanding and tactics
Considering many tumor recurrences after chemotherapy, treatment resistance has attracted great scientific attention. Although there has been some seminal discoveries, such as sequential mutations and cancer stem cells, the successful treatment of cancer still requires a considerable refinement of our knowledge concerning treatment resistance.In doing so, we expect that a more informed and refined approach… Continue reading Overcoming treatment resistance in cancer: current understanding and tactics
Optimized dissociation protocol for isolating human glioma stem cells from tumorspheres via fluorescence-activated cell sorting
• This is the first study to optimize the dissociation protocol for isolating human glioma stem cells (GSCs) from tumorspheres.• Liberase-TL (200µg/ml) is an ideal reagent for isolating GSCs from tumorspheres via fluorescence-activated cell sorting.• Non-enzymatic cell dissociation solution (NECDS) for such a protocol should be carefully considered. (Source: Cancer Letters) from #Medicine-SfakianakisAlexandros via o.lakala70… Continue reading Optimized dissociation protocol for isolating human glioma stem cells from tumorspheres via fluorescence-activated cell sorting
The potential role of boswellic acids in cancer prevention and treatment
• Summarizes the pleiotropic anticancer effects of Boswellic acid and its derivatives in divesre cancers• Highlights the key clinical studies carried out with Boswellic acid in cancer patients. (Source: Cancer Letters) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TVBcXb via IFTTT
Viruses, Vol. 8, Pages 101: Nuclear Translocation of Crk Adaptor Proteins by the Influenza A Virus NS1 Protein
The non-structural protein-1 (NS1) of many influenza A strains, especially those of avian origin, contains an SH3 ligand motif, which binds tightly to the cellular adaptor proteins Crk (Chicken tumor virus number 10 (CT10) regulator of kinase) and Crk-like adapter protein (CrkL). This interaction has been shown to potentiate NS1-induced activation of the phosphatidylinositol 3-kinase… Continue reading Viruses, Vol. 8, Pages 101: Nuclear Translocation of Crk Adaptor Proteins by the Influenza A Virus NS1 Protein
Early transcriptional events in the udder and teat after intra-mammary Escherichia coli and Staphylococcus aureus challenge
Intra-mammary bacterial infections can result in harmful clinical mastitis or subclinical mastitis with persistent infections. Research during the last decades closely examined the pathophysiology of inflamed udders. Initial events after pathogen perception but before the onset of mastitis have not been examined in vivo. The objective of this study was to develop a mastitis model… Continue reading Early transcriptional events in the udder and teat after intra-mammary Escherichia coli and Staphylococcus aureus challenge
Deletion of fabN in Enterococcus faecalis results in unsaturated fatty acid auxotrophy and decreased release of inflammatory cytokines
The Gram-positive bacterium Enterococcus faecalis can cause life-threatening infections and is resistant to several commonly used antibiotics. The type II fatty acid pathway in bacteria is discussed as a potential target for antimicrobial therapy. However, it was shown that inhibition or deletion of its enzymes can be rescued in Gram-positive bacteria by supplementation with fatty… Continue reading Deletion of fabN in Enterococcus faecalis results in unsaturated fatty acid auxotrophy and decreased release of inflammatory cytokines
A New Homozygous Frameshift Mutation in the HSD3B2 Gene in an Apparently Nonconsanguineous Italian Family
Background: 3β-Hydroxysteroid dehydrogenase (3β-HSD) deficiency is a rare cause of congenital adrenal hyperplasia (CAH) caused by inactivating mutations in the HSD3B2 gene. Patient and Methods: We report the molecular and structural analysis of the HSD3B2 gene in a 46,XY child born to apparently nonconsanguineous parents and presenting ambiguous genitalia and salt wasting. The steroid profile… Continue reading A New Homozygous Frameshift Mutation in the HSD3B2 Gene in an Apparently Nonconsanguineous Italian Family
Dysphagia, dystussia, and aspiration pneumonia in elderly people.
*Dysphagia, dystussia, and aspiration pneumonia in elderly people.* J Thorac Dis. 2016 Mar;8(3):632-9 Authors: Ebihara S, Sekiya H, Miyagi M, Ebihara T, Okazaki T Abstract Despite the development and wide distribution of guidelines for pneumonia, death from pneumonia is increasing due to population aging. Conventionally, aspiration pneumonia was mainly thought to be one of the infectious diseases. However, we have proven that chronic repeated aspiration of a small amount of sterile material can cause the usual type of aspiration pneumonia in mouse lung. Moreover, chronic repeated ...περισσότερα »
Feasibility and potential value of lipofilling in post-treatment oropharyngeal dysfunction.
*Feasibility and potential value of lipofilling in post-treatment oropharyngeal dysfunction.* Laryngoscope. 2016 Apr 14; Authors: Kraaijenga SA, Lapid O, van der Molen L, Hilgers FJ, Smeele LE, van den Brekel MW Abstract OBJECTIVES/HYPOTHESIS: Head and neck cancer (HNC) patients may develop oropharyngeal dysfunction as result of volume loss or muscle atrophy of the tongue or pharyngeal musculature following treatment with surgery and/or chemoradiotherapy. If intensive swallowing therapy offers no further improvement, and the functional problems persist, transplantation of autolo... περισσότερα »
[Hyperthyroid and acute tonsillitis in a 23-year-old woman].
*[Hyperthyroid and acute tonsillitis in a 23-year-old woman].* Internist (Berl). 2016 Apr 13; Authors: Beyer G, Küster I, Budde C, Wilhelm E, Hoene A, Evert K, Stracke S, Friesecke S, Mayerle J, Steveling A Abstract A 23-year-old woman with preexisting Graves' disease who received thiamazole treatment presented with fever, dysphagia, hyperthyroidism and leukopenia. With suspicion of thyreotoxicosis accompanied by drug-induced agranulocytosis she was successfully managed by plasmapheresis, G‑CSF administration and inhibition of periphereal conversion of thyroid hormones. In due co...περισσότερα »
EFFECT OF BOLUS SIZE ON DEGLUTITION AND ESOPHAGEAL TRANSIT IN HEALTHY DOGS.
*EFFECT OF BOLUS SIZE ON DEGLUTITION AND ESOPHAGEAL TRANSIT IN HEALTHY DOGS.* Vet Radiol Ultrasound. 2016 Apr 14; Authors: Cheney DM, Marks SL, Pollard RE Abstract Contrast videofluoroscopy is the gold standard procedure for evaluating dysphagia in humans, but quantitative measures vary depending on bolus size and consistency. We hypothesized that quantitative measures made during videofluoroscopy of swallowing in dogs would differ between bolus sizes and consistencies. Ten healthy adult dogs were enrolled a prospective, crossover experimental study and underwent contrast videofl... περισσότερα »
Challenges in establishing the diagnosis of human papillomavirus-related oropharyngeal carcinoma.
*Challenges in establishing the diagnosis of human papillomavirus-related oropharyngeal carcinoma.* Laryngoscope. 2016 Apr 14; Authors: Truong Lam M, O'Sullivan B, Gullane P, Huang SH Abstract OBJECTIVES/HYPOTHESIS: To describe initial presentations and idiosyncrasies in establishing the diagnosis for human papillomavirus-related (HPV(+) ) compared to HPV-unrelated (HPV(-) ) oropharyngeal carcinoma (OPC). STUDY DESIGN: A single institution retrospective series derived from an institutional prospectively compiled database supplemented by chart review. METHODS: We reviewed consecutiv...περισσότερα »
Prevalence of gallstones in 1,229 patients submitted to surgical laparoscopic treatment of GERD and esophageal achalasia: associated cholecystectomy was a safe procedure.
[image: http:--http://ift.tt/1Q7SQUV] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Prevalence of gallstones in 1,229 patients submitted to surgical laparoscopic treatment of GERD and esophageal achalasia: associated cholecystectomy was a safe procedure.* Arq Bras Cir Dig. 2015 Apr-Jun;28(2):113-6 Authors: Sallum RA, Padrão EM, Szachnowicz S, Seguro FC, Bianchi ET, Cecconello I Abstract BACKGROUND: Association between esophageal achalasia/ gastroesophageal reflux disease (GERD) and cholelithiasis is not clear. Epidemiological data are controversial due to different meth... περισσότερα »
Vicryl patch and fibrin glue as treatment of an esophageal leak.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Vicryl patch and fibrin glue as treatment of an esophageal leak.* Gastrointest Endosc. 2015 Aug;82(2):402 Authors: Ribeiro MS, de Barros RA, Wallace MB PMID: 25922259 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1TVpQCt
Use of the stag-beetle knife for peroral endoscopic myotomy for achalasia: a novel method for myotomy.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Use of the stag-beetle knife for peroral endoscopic myotomy for achalasia: a novel method for myotomy.* Gastrointest Endosc. 2015 Aug;82(2):401-2 Authors: Bittinger M, Messmann H PMID: 25922252 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1SFRM86
Comparison of quality of life and worry of cancer recurrence between endoscopic and surgical treatment for early gastric cancer.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Comparison of quality of life and worry of cancer recurrence between endoscopic and surgical treatment for early gastric cancer.* Gastrointest Endosc. 2015 Aug;82(2):299-307 Authors: Choi JH, Kim ES, Lee YJ, Cho KB, Park KS, Jang BK, Chung WJ, Hwang JS, Ryu SW Abstract BACKGROUND: The quality of life (QOL) of patients who survive early gastric cancer (EGC) is an area of increasing interest. OBJECTIVE: To compare the QOL and degree of worry of cancer recurrence in EGC patients who underwent endoscopic submucosal dis...περισσότερα »
Triple A syndrome with a novel indel mutation in the AAAS gene and delayed puberty.
Related Articles *Triple A syndrome with a novel indel mutation in the AAAS gene and delayed puberty.* J Pediatr Endocrinol Metab. 2015 Jul;28(7-8):933-6 Authors: Bustanji H, Sahar B, Huebner A, Ajlouni K, Landgraf D, Hamamy H, Koehler K Abstract Triple A syndrome, formerly known as Allgrove syndrome, is an autosomal recessive disorder characterized clinically by adrenal insufficiency, alacrima, achalasia, and neurological abnormalities. We report a 17-year-old boy presented to the endocrine clinic with delayed puberty and a 4-year's history of fatigue and muscle weakness. He had... περισσότερα »
Euprolactinemic galactorrhea secondary to domperidone treatment.
Related Articles *Euprolactinemic galactorrhea secondary to domperidone treatment.* J Pediatr Endocrinol Metab. 2015 Jul;28(7-8):955-6 Authors: Demir AM, Kuloglu Z, Berberoglu M, Kansu A Abstract Milk leakage from the breast, which is known as galactorrhea, can be caused by a number of pharmacological, physical, and tumoral factors. Galactorrhea is a well-known side effect of domperidone, and is usually associated with hyperprolactinemia. However, euprolactinemic galactorrhea secondary to domperidone is very rarely seen and has yet to be reported in children before. Here, we repor...περισσότερα »
Changes of Esophagogastric Junctional Adenocarcinoma and Gastroesophageal Reflux Disease Among Surgical Patients During 1988-2012: A Single-institution, High-volume Experience in China.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Changes of Esophagogastric Junctional Adenocarcinoma and Gastroesophageal Reflux Disease Among Surgical Patients During 1988-2012: A Single-institution, High-volume Experience in China.* Ann Surg. 2016 Jan;263(1):88-95 Authors: Liu K, Yang K, Zhang W, Chen X, Chen X, Zhang B, Chen Z, Chen J, Zhao Y, Zhou Z, Chen L, Hu J Abstract OBJECTIVE: To evaluate the changes of esophagogastric junctional adenocarcinoma (EGJA) and gastroesophageal reflux disease (GERD) among surgical pati... περισσότερα »
The Impact of Gastric Bypass on Gastroesophageal Reflux Disease in Morbidly Obese Patients.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *The Impact of Gastric Bypass on Gastroesophageal Reflux Disease in Morbidly Obese Patients.* Ann Surg. 2016 Jan;263(1):110-6 Authors: Madalosso CA, Gurski RR, Callegari-Jacques SM, Navarini D, Mazzini G, Pereira Mda S Abstract OBJECTIVE: To assess the impact of Roux-en-Y gastric bypass (GBP) on gastroesophageal reflux disease (GERD) in morbidly obese patients. BACKGROUND: Recently, authors have reported that early results of GBP can control GERD. However, longer follow-ups based on objective parameters for GERD ar...περισσότερα »
Feasibility and potential value of lipofilling in post-treatment oropharyngeal dysfunction.
*Feasibility and potential value of lipofilling in post-treatment oropharyngeal dysfunction.* Laryngoscope. 2016 Apr 14; Authors: Kraaijenga SA, Lapid O, van der Molen L, Hilgers FJ, Smeele LE, van den Brekel MW Abstract OBJECTIVES/HYPOTHESIS: Head and neck cancer (HNC) patients may develop oropharyngeal dysfunction as result of volume loss or muscle atrophy of the tongue or pharyngeal musculature following treatment with surgery and/or chemoradiotherapy. If intensive swallowing therapy offers no further improvement, and the functional problems persist, transplantation of autolo... περισσότερα »
Prevalence of gallstones in 1,229 patients submitted to surgical laparoscopic treatment of GERD and esophageal achalasia: associated cholecystectomy was a safe procedure.
[image: http:--http://ift.tt/1Q7SQUV] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Prevalence of gallstones in 1,229 patients submitted to surgical laparoscopic treatment of GERD and esophageal achalasia: associated cholecystectomy was a safe procedure.* Arq Bras Cir Dig. 2015 Apr-Jun;28(2):113-6 Authors: Sallum RA, Padrão EM, Szachnowicz S, Seguro FC, Bianchi ET, Cecconello I Abstract BACKGROUND: Association between esophageal achalasia/ gastroesophageal reflux disease (GERD) and cholelithiasis is not clear. Epidemiological data are controversial due to different meth... περισσότερα »
Surgical treatment analysis of idiopathic esophageal achalasia.
[image: http:--http://ift.tt/1Q7SQUV] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Surgical treatment analysis of idiopathic esophageal achalasia.* Arq Bras Cir Dig. 2015 Apr-Jun;28(2):98-101 Authors: Aquino JL, Said MM, Pereira DR, Amaral PC, Lima JC, Leandro-Merhi VA Abstract BACKGROUND: Idiopathic esophageal achalasia is an inflammatory disease of unknown origin, characterized by aperistalsis of the esophageal body and failure of the lower esophageal sphincter in response to swallowing, with consequent dysphagia. AIM: To demonstrate the results of surgical therapy in... περισσότερα »
Vicryl patch and fibrin glue as treatment of an esophageal leak.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Vicryl patch and fibrin glue as treatment of an esophageal leak.* Gastrointest Endosc. 2015 Aug;82(2):402 Authors: Ribeiro MS, de Barros RA, Wallace MB PMID: 25922259 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1TVpQCt
Use of the stag-beetle knife for peroral endoscopic myotomy for achalasia: a novel method for myotomy.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Use of the stag-beetle knife for peroral endoscopic myotomy for achalasia: a novel method for myotomy.* Gastrointest Endosc. 2015 Aug;82(2):401-2 Authors: Bittinger M, Messmann H PMID: 25922252 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1SFRM86
Comparison of quality of life and worry of cancer recurrence between endoscopic and surgical treatment for early gastric cancer.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Comparison of quality of life and worry of cancer recurrence between endoscopic and surgical treatment for early gastric cancer.* Gastrointest Endosc. 2015 Aug;82(2):299-307 Authors: Choi JH, Kim ES, Lee YJ, Cho KB, Park KS, Jang BK, Chung WJ, Hwang JS, Ryu SW Abstract BACKGROUND: The quality of life (QOL) of patients who survive early gastric cancer (EGC) is an area of increasing interest. OBJECTIVE: To compare the QOL and degree of worry of cancer recurrence in EGC patients who underwent endoscopic submucosal dis...περισσότερα »
Triple A syndrome with a novel indel mutation in the AAAS gene and delayed puberty.
Related Articles *Triple A syndrome with a novel indel mutation in the AAAS gene and delayed puberty.* J Pediatr Endocrinol Metab. 2015 Jul;28(7-8):933-6 Authors: Bustanji H, Sahar B, Huebner A, Ajlouni K, Landgraf D, Hamamy H, Koehler K Abstract Triple A syndrome, formerly known as Allgrove syndrome, is an autosomal recessive disorder characterized clinically by adrenal insufficiency, alacrima, achalasia, and neurological abnormalities. We report a 17-year-old boy presented to the endocrine clinic with delayed puberty and a 4-year's history of fatigue and muscle weakness. He had... περισσότερα »
Association of Human Papillomavirus and p16 Status With Outcomes in the IMCL-9815 Phase III Registration Trial for Patients With Locoregionally Advanced Oropharyngeal Squamous Cell Carcinoma of the Head and Neck Treated With Radiotherapy With or Without Cetuximab
[Rapid Communication]: Purpose We conducted a retrospective evaluation of the IMCL-9815 study to examine the association of human papillomavirus (HPV) and p16 protein expression status with outcomes in patients with oropharyngeal carcinoma (OPC) receiving radiotherapy (RT) plus cetuximab or RT alone. Patients and Methods In the IMCL-9815 study, patients were randomly allocated to receive RT plus weekly cetuximab or RT alone. A subpopulation of patients with p16-evaluable OPC was retrospectively evaluated on the basis of locoregional control (LRC), overall survival (OS), and progre...περισσότερα »
Autologous Monocyte-Derived mRNA Electroporated Dendritic Cells (TriMixDC-MEL) Plus Ipilimumab in Patients With Pretreated Advanced Melanoma
Phase II Study of Purpose Autologous monocyte-derived dendritic cells (DCs) electroporated with synthetic mRNA (TriMixDC-MEL) are immunogenic and have antitumor activity as a monotherapy in patients with pretreated advanced melanoma. Ipilimumab, an immunoglobulin G1 monoclonal antibody directed against the cytotoxic T-lymphocyte-associated protein 4 receptor that counteracts physiologic suppression of T-cell function, improves the overall survival of patients with advanced melanoma. This phase II study investigated the combination of TriMixDC-MEL and ipilimumab in patients with pre... περισσότερα »
Mantle-cell lymphoma (MCL) : Prognostic Value of Ki-67 Index, Cytology, and Growth Pattern
Results From Randomized Trials of the European Mantle Cell Lymphoma Network [Hematologic Malignancy]: Purpose Mantle-cell lymphoma (MCL) is a rather aggressive B-cell malignancy whose considerable variability of individual outcome is associated with clinical characteristics (Mantle Cell Lymphoma International Prognostic Index [MIPI]). The Ki-67 index is a strong independent prognostic factor; however, the biologic MIPI (MIPI-b) distinguishes only two groups, which does not appropriately depict the clinical heterogeneity. By using the cohort from the European MCL Younger and MCL Elde...περισσότερα »
Management of Skin Reactions During Cetuximab Treatment in Association With Chemotherapy or Radiotherapy: Update of the Italian Expert Recommendations.
Update of the Italian Expert Recommendations.: Objectives: Cetuximab was shown in phase III clinical trials to improve chemotherapy efficacy in patients with advanced colorectal and head-neck cancer. Appropriate management of skin reactions associated with epidermal growth factor receptor inhibitor therapy is necessary to allow adequate drug compliance and to improve patient quality of life and outcomes. Methods: The RAND/UCLA Appropriateness Method was used by a group of experts to produce new Italian recommendations on the management of skin reactions in this setting. Statements ... περισσότερα »
Hypophosphatemia with Increased Urinary Excretion of Phosphorus Associated with Ibrutinib
A Case of Ibrutinib, an irreversible oral inhibitor of Bruton's tyrosine kinase, has been used in the treatment of patients with multiple hematologic malignancies. A 59-year-old male with chronic lymphocytic leukemia was treated with 420 mg/day of ibrutinib. No evidence of bruising or diarrhea was noted. The treatment was complicated by a transient increase in creatinine (from a baseline of 1.2 to 1.5 mg/dl) and potassium (reaching a peak of 6.5 mEq/l). Uric acid and calcium levels were normal. The patient developed hypophosphatemia (prior to initiation of therapy the serum phosph... περισσότερα »
Detectable Blood Lead Level and Body Size in Early Childhood
Detectable Blood Lead Level and Body Size in Early Childhood: AbstractRates of childhood obesity have risen at the same time rates of high blood lead levels (BLLs) have fallen. Recent studies suggest that higher BLL is inversely associated with body size in older children (ages 3–19 years). No contemporaneous studies have examined if having a detectable BLL is associated with body size in very early childhood. We examined if detectable BLL is associated with body size in early childhood. A total of 299 birth cohort participants completed a study visit at ages 2–3 years with weight ... περισσότερα »
Role of Magnesium Transporter Subtype 1 (MagT1) in the Osteogenic Differentiation of Rat Bone Marrow Stem Cells
Role of Magnesium Transporter Subtype 1 (MagT1) in the Osteogenic Differentiation of Rat Bone Marrow Stem Cells: AbstractIn the present study, we investigated the role of magnesium transporter subtype 1 (MagT1), a selective Mg transporter protein, in the osteogenic differentiation of rat bone marrow stem cells (rBMSCs). Osteogenic differentiation was monitored by the expressions of alkaline phosphatase (ALP), osteocalcin (OCN), collagen-1 (COL-1) and runt-related transcription factor 2 (RUNX2), and extracellular matrix mineralization of rBMSCs. The expression of MagT1 increased wit...περισσότερα »
Anti-Apoptotic and Anti-Oxidant Effects of Caffeic Acid Phenethyl Ester
on Cadmium-Induced Testicular Toxicity in Rats: AbstractCadmium (Cd) is a serious environmental and occupational contaminant and may represent a serious health hazard to humans and other animals. Cd is reported to induce the generation of reactive oxygen species, and induces testicular damage in many species of animals. The goal of our study was to examine the anti-apoptotic and anti-oxidant effects of caffeic acid phenethyl ester (CAPE) on Cd-induced oxidative stress, apoptosis, and testicular injury in rats. A total of 40 male Wistar albino rats were divided into four groups: co...περισσότερα »
A New Homozygous Frameshift Mutation in the HSD3B2 Gene in an Apparently Nonconsanguineous Italian Family
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Background: 3β-Hydroxysteroid dehydrogenase (3β-HSD) deficiency is a rare cause of congenital adrenal hyperplasia (CAH) caused by inactivating mutations in the HSD3B2 gene. Patient and Methods: We report the molecular and structural analysis of the HSD3B2 gene in a 46,XY child born to apparently nonconsanguineous parents and presenting ambiguous genitalia and salt wasting. The steroid profile […]
IJMS, Vol. 17, Pages 569: Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Obesity and diabetes are the most prevailing health concerns worldwide and their incidence is increasing at a high rate, resulting in enormous social costs. Obesity is a complex disease commonly accompanied by insulin resistance and increases in oxidative stress and inflammatory marker expression, leading to augmented fat mass in the body. Diabetes mellitus (DM) is […]
IJMS, Vol. 17, Pages 573: Current Insights into Long Non-Coding RNAs in Renal Cell Carcinoma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Renal cell carcinoma (RCC) represents a deadly disease with rising mortality despite intensive therapeutic efforts. It comprises several subtypes in terms of distinct histopathological features and different clinical presentations. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts in the genome which vary in expression levels and length and perform diverse functions. They are involved in the […]
IJMS, Vol. 17, Pages 411: Intra-Articular Injection of Cross-Linked Hyaluronic Acid-Dexamethasone Hydrogel Attenuates Osteoarthritis: An Experimental Study in a Rat Model of Osteoarthritis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Cross-linked hyaluronic acid hydrogel (cHA gel) and dexamethasone (Dex) have been used to treat knee osteoarthritis (OA) in clinical practice owing to their chondroprotective and anti-inflammatory effects, respectively. The aim of the present study was to compare the treatment effects of the cHA gel pre-mixed with/without Dex in a surgery-induced osteoarthritis model in rats. Anterior […]
IJMS, Vol. 17, Pages 575: Hybrid Macro-Porous Titanium Ornamented by Degradable 3D Gel/nHA Micro-Scaffolds for Bone Tissue Regeneration
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Porous titanium is a kind of promising material for bone substitution, while its bio-inert property results in demand of modifications to improve the osteointegration capacity. In this study, gelatin (Gel) and nano-hydroxyapatite (nHA) were used to construct 3D micro-scaffolds in the pores of porous titanium in the ratios of Gel:nHA = 1:0, Gel:nHA = 1:1, […]
Protective mastectomies that preserve nipple safe for women at high breast cancer risk
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Protective mastectomies that preserve the nipple and surrounding skin prevent breast cancer as effectively as more invasive surgeries for women with a genetic mutation called BRCA that raises their risk of developing breast cancer, a multi-institution… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1T8XHp9 via IFTTT
Low-grade brain tumours: Radiation plus chemotherapy is best treatment, trial suggests
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
New clinical-trial findings show that patients with a low-grade form of brain cancer who are treated with radiation plus a combination of chemotherapy drugs have better survival than patients treated with radiation alone. The study, published in the New… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1qLjYQO via IFTTT
Neratinib plus paclitaxel vs trastuzumab plus paclitaxel in breast cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
While neratinib plus paclitaxel was not superior to trastuzumab plus paclitaxel as first-line treatment for ERBB2-positive metastatic breast cancer in terms of progression-free survival, the combination was associated with delayed onset and reduced… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1T8XH8T via IFTTT
Selenium and Antioxidant Status in Dairy Cows
at Different Stages of Lactation: AbstractThirty-five multiparous Holstein cows averaging 550 ± 50 kg of body weight and in 2 to 4 parity were divided into three groups according to lactation stage (group A: nine cows from 4 to 1 weeks prepartum; group B: 11 cows from 1 to 30 days postpartum; group C: 15 cows from 30 to 100 days postpartum). Selenium concentration, malondialdehyde (MDA) level, glutathione peroxidase (GSH-Px) activity, thioredoxin reductase (TrxR) activity, and total antioxidant status (TAS) in serum were determined to evaluate selenium and antioxidant status in da...περισσότερα »
Cutaneous clear cell hidradenoma is an uncommon benign adnexal tumor
LYMPH NODE LOCATION OF A CLEAR CELL HIDRADENOMA: REPORT OF A PATIENT AND REVIEW OF LITERATURE: Abstract Cutaneous clear cell hidradenoma is an uncommon benign adnexal tumor which is not supposed to metastasize, contrary to its rare malignant counterpart, hidradenocarcinoma. We report the case of a 49-year-old man, who had had a stable inguinal lymph node enlargement for six years. An excision was performed and revealed an intra-nodal tumor, made of large clear cells with abundant cytoplasm and round nuclei without atypia or mitosis. The immunohistochemical staining showed diffuse p... περισσότερα »
The tumor microenvironment in cutaneous CD30-positive lymphoproliferative disorders
CHARACTERIZATION OF THE TUMOR MICROENVIRONMENT IN PRIMARY CUTANEOUS CD30-POSITIVE LYMPHOPROLIFERATIVE DISORDERS: A PREDOMINANCE OF CD163-POSITIVE M2 MACROPHAGES: ABSTRACT Background The tumor microenvironment is essential for tumor survival, growth, and progression. There are only a few studies on the tumor microenvironment in cutaneous CD30-positive lymphoproliferative disorders. Methods We assessed the composition of the tumor microenvironment using immunohistochemistry studies in skin biopsies from cases diagnosed with lymphomatoid papulosis (LyP: 18 specimens), primary cutaneous... περισσότερα »
Salivary duct carcinoma with rhabdoid features
: a salivary counterpart against pleomorphic lobular carcinoma of the breast: [image: cover.gif?v=1&s=262335eb92c2f966a0a1e7e1] Abstract Aim We analyzed the clinicopathologic features and immunohistochemical characteristics of 9 cases of salivary duct carcinoma (SDC) with rhabdoid features (SDCRF), representing a new, extremely rare type of salivary gland malignancy. Methods and results We analyzed 2511 cases of salivary gland tumors, clinicopathologically and immunohistochemically. The incidence of SDCRF was 0.4%. Eight patients were male. Age ranged from 36–85 years (mean, 61 ...περισσότερα »
CIC-DUX4 Fusion-Positive Round Cell Sarcomas of soft tissue and bone
a single institution morphologic and molecular analysis of 7 cases: [image: cover.gif?v=1&s=262335eb92c2f966a0a1e7e1] Abstract Aims Round cell sarcomas lacking specific translocations represent a diagnostic challenge. The aim of this study is to describe seven cases of *CIC-DUX4* positive sarcomas, including the first reported example arising primarily in bone. Methods and results Patients ranged in age from 15 to 44 years (median: 33). Six cases arose from the soft tissues and one from the iliac bone. Morphologically, all cases showed an undifferentiated round cell population w... περισσότερα »
Epithelioid Schwannomas
An Analysis of 58 Cases Including Atypical Variants: [image: image] The histologic features and outcome of 58 cases of epithelioid schwannoma were studied to determine the significance of atypical histologic features. Cases were retrieved from personal consultation files from 1999 to 2013. Patients (31 male and 26 female patients) ranged in age from 14 to 80 years (median, 38 y). Two patients had schwannomatosis 1. Tumors developed in the dermis/subcutis (n=56) or muscle (n=2) of the upper extremity (34.5%), lower extremity (34.5%), thorax/abdomen/back (18%), and less common anatom...περισσότερα »
Barrett’s Esophagus
A Comprehensive and Contemporary Review for Pathologists: [image: image]This review provides a summary of our current understanding of, and the controversies surrounding, the diagnosis, pathogenesis, histopathology, and molecular biology of Barrett’s esophagus (BE) and associated neoplasia. BE is defined as columnar metaplasia of the esophagus. There is worldwide controversy regarding the diagnostic criteria of BE, mainly with regard to the requirement to histologically identify goblet cells in biopsies. Patients with BE are at increased risk for adenocarcinoma, which develops in a... περισσότερα »
Primary Pseudomyogenic Hemangioendothelioma of Bone
Primary Pseudomyogenic Hemangioendothelioma of Bone: Pseudomyogenic hemangioendothelioma (PMH) is a well-recognized neoplasm that usually arises in the soft tissue; concurrent bone involvement occurs in 24% of cases. PMH of bone without soft tissue involvement is rare. We describe the clinicopathologic findings of 10 such cases, the largest series reported to date. The study included 9 male and 1 female patient; their ages ranged from 12 to 74 years (mean 36.7 y). All patients had multiple tumors with a distinct regional distribution: 45% restricted to the lower extremity; 25% to t...περισσότερα »
Cytomorphology of Recurrent Osseous Extracranial Meningioma of Right Pubic Ramus:
Cytomorphology of Recurrent Osseous Extracranial Meningioma of Right Pubic Ramus:: Meningiomas are well-recognized neoplasms of the central nervous system. Primary extracranial meningiomas (ECMs) are extremely rare and arise in various anatomic sites. We present a 56-year-old female with 13-year history of primary grade I meningothelial meningioma of right pubic symphysis, orthotopic heart transplant, and right total hip arthroplasty, who presented with progressive right hip pain for 3 weeks. Primary intracranial, intraspinal and other tumors were excluded. Imaging revealed a dest... περισσότερα »
Osteoclast-Like Giant Cell Tumor of the Parotid Gland
Report of a Case Diagnosed on Fine-Needle Aspiration Cytology With Histological and Immunohistochemical Findings: Extraosseous giant cell tumors have been described in organs like larynx, thyroid, pancreas, heart, skin, lung, colon, kidney, and soft tissues (Wu et al., Oncol Lett 2013;6:829–832). Osteoclast-like giant cell tumor of the parotid gland has been reported only rarely with the first description of primary giant cell tumour of the parotid gland (GCTPs) given in 1984 by Eusebi et al. (Am J Clin Pathol. 1984;81:666–675). However, FNAC of osteoclast-like giant cell tumor of ... περισσότερα »
Neurodevelopmental Deficit After Exposure to Anesthesia in Early Childhood.
Latent Class Analysis of Introduction: Although some studies have reported an association between early exposure to anesthesia and surgery and long-term neurodevelopmental deficit, the clinical phenotype of children exposed to anesthesia is still unknown. Methods: Data were obtained from the Western Australian Pregnancy Cohort Study (Raine) with neuropsychological tests at age 10 years measuring language, cognition, motor function, and behavior. Latent class analysis of the tests was used to divide the cohort into mutually exclusive subclasses of neurodevelopmental deficit. Multiv... περισσότερα »
Extended boiling of peanut progressively reduces IgE allergenicity while retaining T cell reactivity
Extended boiling of peanut progressively reduces IgE allergenicity while retaining T cell reactivity: Abstract Background Current peanut oral immunotherapy is hampered by frequent adverse events. It has been shown that boiling can reduce peanut allergenicity. Hypoallergenic peanut products have the potential to reduce treatment-related reactions during desensitisation. Objective To show that extended boiling (for up to 12 hours) can progressively reduce peanut allergenicity while retaining T-cell reactivity. Methods Raw peanuts were boiled for half, 1, 2, 4 and 12 hours in deionized ... περισσότερα »
Elevated Levels of Circulating CD4+CRTh2+ T cells Characterize Severe Asthma
Elevated Levels of Circulating CD4+CRTh2+ T cells Characterize Severe Asthma: Abstract Background Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) is a receptor for PGD2 and expressed by T cells, eosinophils, basophils and ILC2 cells. CRTh2 expression by CD4+ T cells identifies the Th2 subset and these cells have been characterized as allergen-specific central memory Th2 cells. Recently, activation of the PGD2-CRTh2 pathway in the lungs was associated with severe asthma. Objective To assess circulating levels of Th2 cells and related mediators in severe a... περισσότερα »
Dynamics of plasma levels of specific IgE in chlorhexidine allergic patients with and without accidental re-exposure
Dynamics of plasma levels of specific IgE in chlorhexidine allergic patients with and without accidental re-exposure: Abstract Background Chlorhexidine is an effective disinfectant, which may cause severe allergic reactions. Plasma level of specific IgE to chlorhexidine (ImmunoCAP®) has high estimated sensitivity and specificity when measured within six months of allergic reaction, but knowledge of the dynamics over longer time periods is lacking and it is unknown whether levels fall below <0.35kUA/l in patients with previously elevated levels. It is also unclear whether re-exposur... περισσότερα »
Human bronchial and parenchymal fibroblasts display differences in basal inflammatory phenotype and response to IL-17A
Human bronchial and parenchymal fibroblasts display differences in basal inflammatory phenotype and response to IL-17A: Abstract Background Chronic inflammation, typified by increased expression of IL-17A, together with airway and parenchymal remodeling are features of chronic lung diseases. Emerging evidence suggests that phenotypic heterogeneity of repair and inflammatory capacities of fibroblasts may contribute to the differential structural changes observed in different regions of the lung. Objective To investigate phenotypic differences in parenchymal and bronchial fibroblasts,... περισσότερα »
Resistin is a predictor of asthma risk and resistin: adiponectin ratio is a negative predictor of lung function in asthma
Resistin is a predictor of asthma risk and resistin: adiponectin ratio is a negative predictor of lung function in asthma: Abstract Background Adipokines, such as resistin and adiponectin, modify inflammation and may contribute to increased asthma risk and severity in obese people. Objective To examine plasma resistin and resistin: adiponectin ratio: (1) in asthmatics compared to healthy controls, (2) according to asthma severity, obesity and gender (3) following weight loss in obese asthmatics. Methods In a cross-sectional observational study of asthmatic adults (n=96) and healthy c...περισσότερα »
Improvements in psychological dysfunction after endoscopic sinus surgery for patients with chronic rhinosinusitis
Improvements in psychological dysfunction after endoscopic sinus surgery for patients with chronic rhinosinusitis: Background Psychological dysfunction is highly prevalent among patients with chronic rhinosinusitis (CRS). Previous study has identified various measures of anxiety and depression as predictors of quality-of-life outcomes following endoscopic sinus surgery (ESS). Psychological dysfunction scores, as measured by the 22-item Sino-Nasal Outcome Test (SNOT-22), have been found to influence treatment decision making in CRS. This study aims to further elucidate improvement i...περισσότερα »
Gender-specific analysis of outcomes from endoscopic sinus surgery for chronic rhinosinusitis
Gender-specific analysis of outcomes from endoscopic sinus surgery for chronic rhinosinusitis: Background Women electing endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) report higher symptom burden but have lower computed tomography (CT) scores. Gender-specific analysis of outcomes from ESS therefore merits further study. The objective of this work was to study gender-specific differences in outcomes from ESS for CRS by analyzing preoperative and postoperative 22-item Sino-Nasal Outcome Test (SNOT-22) scores. Methods Data from adult CRS patients electing ESS (2011-20... περισσότερα »
Effects of a honeybee lactic acid bacterial microbiome on human nasal symptoms, commensals, and biomarkers
Effects of a honeybee lactic acid bacterial microbiome on human nasal symptoms, commensals, and biomarkers: Background Lactic acid bacteria (LAB) can restore commensal microbiomes and prevent infections. Arguably, nasal administrations of LAB may therefore be beneficial in chronic rhinosinusitis (CRS). Previous studies have examined effects of topical/nasal LAB in children with secretory otitis media, but little is as yet known about their effects on the human nasal airway. The aim of this pilot study was to examine effects on nasal symptoms and commensal bacteria in healthy subjec...περισσότερα »
Association of intracellular Staphylococcus aureus with prognosis in chronic rhinosinusitis
Association of intracellular Staphylococcus aureus with prognosis in chronic rhinosinusitis: Background *Staphylococcus aureus* (*S. aureus*) has been shown to exist within nasal epithelial cells in chronic rhinosinusitis (CRS) patients. This study investigates the localization of intracellular *S. aureus* (ICSA) in CRS patients, the associated histopathology changes, and their effect on long-term postoperative outcomes. Methods A prospective study of patients with CRS with and without polyps and control patients (n = 25, 15, and 8, respectively) undergoing endoscopic sinus surgery... περισσότερα »
Sunscreen Sun Protection Factor
claim based on in vivo interlaboratory variability: Abstract Objective The SPF (Sun Protection Factor) is the best known reference in the world for expressing UVB protection. The SPF is used for labeling purposes for consumer guidance. The determination of the SPF is often accomplished by using an in vivo method that has been standardized. Only one in vivo SPF value from one laboratory is required for claiming an SPF value. The aim of the present paper is to determine the relevance of the in vivo SPF value in terms of interlaboratory variability for claiming purposes and to determi... περισσότερα »
Sensitive skin : Defects in stratum corneum (SC) barrier function and/or extrasensory neuronal networks in the epidermis
A fundamental investigation into aspects of the physiology and biochemistry of the stratum corneum in subjects with sensitive skin: Abstract Background Sensitive skin is a poorly understood skin condition. Defects in stratum corneum (SC) barrier function and/or extrasensory neuronal networks in the epidermis are believed to be involved in the problem. Objectives This study aimed to unravel the relationships between bleomycin hydrolase (BH) and calpain-1 (C-1), pyrrolidone carboxylic acid (PCA) levels, corneocyte maturation, transglutaminase (TG) and plasmin activities on the cheeks ... περισσότερα »
Effect of the quorum-sensing luxS gene on biofilm formation by Enterococcus faecalis
Effect of the quorum-sensing luxS gene on biofilm formation by Enterococcus faecalis: *Enterococcus faecalis* is the species of bacterium most frequently isolated from the root canals of teeth that exhibit chronic apical periodontitis refractory to endodontic treatment. In this study, we evaluated the effect of the S-ribosylhomocysteine lyase (*luxS*) quorum-sensing gene on *E. faecalis* biofilm formation by constructing a knockout mutant. The biofilms formed by both *E. faecalis* and its *luxS* mutant strain were evaluated using the MTT method. Important parameters that influence... περισσότερα »
Transthyrohyoid access to the larynx for endoscopic resection of early-stage glottic cancer
Transthyrohyoid access to the larynx for endoscopic resection of early-stage glottic cancer: Abstract Background The effectiveness of transoral microsurgery for early-stage glottic cancer relies on the possibility to obtain adequate exposure of the lesion. The purpose of this study was to design a new surgical technique allowing efficient endoscopic removal of these tumors in patients with unsatisfactory transoral exposure. Methods A minimal invasive access to the glottis, made through the thyrohyoid membrane and the preepiglottic space, was used for endoscopic resection of an earl... περισσότερα »
Population-based validation of the recursive partitioning analysis–based staging system for oropharyngeal cancer
Population-based validation of the recursive partitioning analysis–based staging system for oropharyngeal cancer: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background The American Joint Committee on Cancer (AJCC) staging system does not adequately distinguish prognostic groups in the era of human papillomavirus (HPV)-related oropharyngeal cancer. The purpose of this study was to validate a recursive partitioning analysis (RPA)-based stage grouping on a population-wide level. Methods We identified 8427 patients in Surveillance, Epidemiology, and End Results (SEER... περισσότερα »
Minimally invasive carcinosarcoma ex pleomorphic adenoma
A case report and literature review with cytohistological correlation: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background Carcinosarcoma of the salivary glands is a rare neoplasm, and the minimally invasive form constitutes a subgroup with a more favorable prognosis. The cytomorphologic features of this neoplasm can be appreciated on fine-needle aspiration biopsy. Methods and Results We present a patient with a minimally invasive carcinosarcoma ex non-recurrent pleomorphic adenoma (Ca ex PA) who underwent initial fine-needle aspiration biopsy followed by surgi... περισσότερα »
Salivary duct carcinoma of the sinonasal cavity
: A case report and review of the literature: ABSTRACT Background Salivary duct carcinoma is a rare, aggressive tumor entity first described by Kleinsasser et al in 1968, as a group of malignant salivary gland tumors characterized by duct formation and central necrosis. A case with an unusual localization in the nasal cavity and maxillary sinus is being described in our report. Methods A 60-year-old patient presented with difficulty of nasal breathing and recurrent episodes of epistaxis from the left nasal cavity over the previous 3 months. On endoscopy, a vulnerable lesion in the l... περισσότερα »
Clinical characteristics and outcomes of oropharyngeal carcinoma related to high-risk non–human papillomavirus16 viral subtypes
Clinical characteristics and outcomes of oropharyngeal carcinoma related to high-risk non–human papillomavirus16 viral subtypes: Abstract Background The majority of human papillomavirus (HPV)-related oropharyngeal carcinomas (OPCs) are associated with HPV genotype 16; however, OPC can be associated with other high-risk non-HPV16 genotypes. Methods This was a retrospective analysis of patients with high-risk non-HPV16 OPC treated at a single tertiary institution. Sociodemographic and clinical information was obtained by chart review. HPV genotype was determined by polymerase chain re... περισσότερα »
Neurologic late effects associated with radiologic evidence of vertebral osteoradionecrosis after salvage laryngectomy: A syndrome associated with survivors of laryngeal and hypopharyngeal cancer
Neurologic late effects associated with radiologic evidence of vertebral osteoradionecrosis after salvage laryngectomy: A syndrome associated with survivors of laryngeal and hypopharyngeal cancer: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background Delayed nonspecific posterior neck pain after pharyngeal instrumentation can be associated with a syndrome of rapidly progressive neurologic embarrassment. We present this cohort to help define the syndrome and aid in early detection. Methods We conducted a retrospective case series of 6 patients presenting from 2003 ... περισσότερα »
Dysphagia, dystussia, and aspiration pneumonia in elderly people.
*Dysphagia, dystussia, and aspiration pneumonia in elderly people.* J Thorac Dis. 2016 Mar;8(3):632-9 Authors: Ebihara S, Sekiya H, Miyagi M, Ebihara T, Okazaki T Abstract Despite the development and wide distribution of guidelines for pneumonia, death from pneumonia is increasing due to population aging. Conventionally, aspiration pneumonia was mainly thought to be one of the infectious diseases. However, we have proven that chronic repeated aspiration of a small amount of sterile material can cause the usual type of aspiration pneumonia in mouse lung. Moreover, chronic repeated ...περισσότερα »
Feasibility and potential value of lipofilling in post-treatment oropharyngeal dysfunction.
*Feasibility and potential value of lipofilling in post-treatment oropharyngeal dysfunction.* Laryngoscope. 2016 Apr 14; Authors: Kraaijenga SA, Lapid O, van der Molen L, Hilgers FJ, Smeele LE, van den Brekel MW Abstract OBJECTIVES/HYPOTHESIS: Head and neck cancer (HNC) patients may develop oropharyngeal dysfunction as result of volume loss or muscle atrophy of the tongue or pharyngeal musculature following treatment with surgery and/or chemoradiotherapy. If intensive swallowing therapy offers no further improvement, and the functional problems persist, transplantation of autolo... περισσότερα »
[Hyperthyroid and acute tonsillitis in a 23-year-old woman].
*[Hyperthyroid and acute tonsillitis in a 23-year-old woman].* Internist (Berl). 2016 Apr 13; Authors: Beyer G, Küster I, Budde C, Wilhelm E, Hoene A, Evert K, Stracke S, Friesecke S, Mayerle J, Steveling A Abstract A 23-year-old woman with preexisting Graves' disease who received thiamazole treatment presented with fever, dysphagia, hyperthyroidism and leukopenia. With suspicion of thyreotoxicosis accompanied by drug-induced agranulocytosis she was successfully managed by plasmapheresis, G‑CSF administration and inhibition of periphereal conversion of thyroid hormones. In due co...περισσότερα »
EFFECT OF BOLUS SIZE ON DEGLUTITION AND ESOPHAGEAL TRANSIT IN HEALTHY DOGS.
*EFFECT OF BOLUS SIZE ON DEGLUTITION AND ESOPHAGEAL TRANSIT IN HEALTHY DOGS.* Vet Radiol Ultrasound. 2016 Apr 14; Authors: Cheney DM, Marks SL, Pollard RE Abstract Contrast videofluoroscopy is the gold standard procedure for evaluating dysphagia in humans, but quantitative measures vary depending on bolus size and consistency. We hypothesized that quantitative measures made during videofluoroscopy of swallowing in dogs would differ between bolus sizes and consistencies. Ten healthy adult dogs were enrolled a prospective, crossover experimental study and underwent contrast videofl... περισσότερα »
Challenges in establishing the diagnosis of human papillomavirus-related oropharyngeal carcinoma.
*Challenges in establishing the diagnosis of human papillomavirus-related oropharyngeal carcinoma.* Laryngoscope. 2016 Apr 14; Authors: Truong Lam M, O'Sullivan B, Gullane P, Huang SH Abstract OBJECTIVES/HYPOTHESIS: To describe initial presentations and idiosyncrasies in establishing the diagnosis for human papillomavirus-related (HPV(+) ) compared to HPV-unrelated (HPV(-) ) oropharyngeal carcinoma (OPC). STUDY DESIGN: A single institution retrospective series derived from an institutional prospectively compiled database supplemented by chart review. METHODS: We reviewed consecutiv...περισσότερα »
Prevalence of gallstones in 1,229 patients submitted to surgical laparoscopic treatment of GERD and esophageal achalasia: associated cholecystectomy was a safe procedure.
[image: http:--http://ift.tt/1Q7SQUV] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Prevalence of gallstones in 1,229 patients submitted to surgical laparoscopic treatment of GERD and esophageal achalasia: associated cholecystectomy was a safe procedure.* Arq Bras Cir Dig. 2015 Apr-Jun;28(2):113-6 Authors: Sallum RA, Padrão EM, Szachnowicz S, Seguro FC, Bianchi ET, Cecconello I Abstract BACKGROUND: Association between esophageal achalasia/ gastroesophageal reflux disease (GERD) and cholelithiasis is not clear. Epidemiological data are controversial due to different met... περισσότερα »
Vicryl patch and fibrin glue as treatment of an esophageal leak.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Vicryl patch and fibrin glue as treatment of an esophageal leak.* Gastrointest Endosc. 2015 Aug;82(2):402 Authors: Ribeiro MS, de Barros RA, Wallace MB PMID: 25922259 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via a.lsfakia on Inoreader http://ift.tt/1TVpQCt via IFTTT
Use of the stag-beetle knife for peroral endoscopic myotomy for achalasia: a novel method for myotomy.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Use of the stag-beetle knife for peroral endoscopic myotomy for achalasia: a novel method for myotomy.* Gastrointest Endosc. 2015 Aug;82(2):401-2 Authors: Bittinger M, Messmann H PMID: 25922252 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via a.lsfakia on Inoreader http://ift.tt/1SFRM86 via IFTTT
Comparison of quality of life and worry of cancer recurrence between endoscopic and surgical treatment for early gastric cancer.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Comparison of quality of life and worry of cancer recurrence between endoscopic and surgical treatment for early gastric cancer.* Gastrointest Endosc. 2015 Aug;82(2):299-307 Authors: Choi JH, Kim ES, Lee YJ, Cho KB, Park KS, Jang BK, Chung WJ, Hwang JS, Ryu SW Abstract BACKGROUND: The quality of life (QOL) of patients who survive early gastric cancer (EGC) is an area of increasing interest. OBJECTIVE: To compare the QOL and degree of worry of cancer recurrence in EGC patients who underwent endoscopic submucosal di... περισσότερα »
Triple A syndrome with a novel indel mutation in the AAAS gene and delayed puberty.
Related Articles *Triple A syndrome with a novel indel mutation in the AAAS gene and delayed puberty.* J Pediatr Endocrinol Metab. 2015 Jul;28(7-8):933-6 Authors: Bustanji H, Sahar B, Huebner A, Ajlouni K, Landgraf D, Hamamy H, Koehler K Abstract Triple A syndrome, formerly known as Allgrove syndrome, is an autosomal recessive disorder characterized clinically by adrenal insufficiency, alacrima, achalasia, and neurological abnormalities. We report a 17-year-old boy presented to the endocrine clinic with delayed puberty and a 4-year's history of fatigue and muscle weakness. He ha... περισσότερα »
Euprolactinemic galactorrhea secondary to domperidone treatment.
Related Articles *Euprolactinemic galactorrhea secondary to domperidone treatment.* J Pediatr Endocrinol Metab. 2015 Jul;28(7-8):955-6 Authors: Demir AM, Kuloglu Z, Berberoglu M, Kansu A Abstract Milk leakage from the breast, which is known as galactorrhea, can be caused by a number of pharmacological, physical, and tumoral factors. Galactorrhea is a well-known side effect of domperidone, and is usually associated with hyperprolactinemia. However, euprolactinemic galactorrhea secondary to domperidone is very rarely seen and has yet to be reported in children before. Here, we repo...περισσότερα »
Changes of Esophagogastric Junctional Adenocarcinoma and Gastroesophageal Reflux Disease Among Surgical Patients During 1988-2012: A Single-institution, High-volume Experience in China.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Changes of Esophagogastric Junctional Adenocarcinoma and Gastroesophageal Reflux Disease Among Surgical Patients During 1988-2012: A Single-institution, High-volume Experience in China.* Ann Surg. 2016 Jan;263(1):88-95 Authors: Liu K, Yang K, Zhang W, Chen X, Chen X, Zhang B, Chen Z, Chen J, Zhao Y, Zhou Z, Chen L, Hu J Abstract OBJECTIVE: To evaluate the changes of esophagogastric junctional adenocarcinoma (EGJA) and gastroesophageal reflux disease (GERD) among surgical pat... περισσότερα »
The Impact of Gastric Bypass on Gastroesophageal Reflux Disease in Morbidly Obese Patients.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *The Impact of Gastric Bypass on Gastroesophageal Reflux Disease in Morbidly Obese Patients.* Ann Surg. 2016 Jan;263(1):110-6 Authors: Madalosso CA, Gurski RR, Callegari-Jacques SM, Navarini D, Mazzini G, Pereira Mda S Abstract OBJECTIVE: To assess the impact of Roux-en-Y gastric bypass (GBP) on gastroesophageal reflux disease (GERD) in morbidly obese patients. BACKGROUND: Recently, authors have reported that early results of GBP can control GERD. However, longer follow-ups based on objective parameters for GERD a... περισσότερα »
Feasibility and potential value of lipofilling in post-treatment oropharyngeal dysfunction.
*Feasibility and potential value of lipofilling in post-treatment oropharyngeal dysfunction.* Laryngoscope. 2016 Apr 14; Authors: Kraaijenga SA, Lapid O, van der Molen L, Hilgers FJ, Smeele LE, van den Brekel MW Abstract OBJECTIVES/HYPOTHESIS: Head and neck cancer (HNC) patients may develop oropharyngeal dysfunction as result of volume loss or muscle atrophy of the tongue or pharyngeal musculature following treatment with surgery and/or chemoradiotherapy. If intensive swallowing therapy offers no further improvement, and the functional problems persist, transplantation of autolo... περισσότερα »
Prevalence of gallstones in 1,229 patients submitted to surgical laparoscopic treatment of GERD and esophageal achalasia: associated cholecystectomy was a safe procedure.
[image: http:--http://ift.tt/1Q7SQUV] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Prevalence of gallstones in 1,229 patients submitted to surgical laparoscopic treatment of GERD and esophageal achalasia: associated cholecystectomy was a safe procedure.* Arq Bras Cir Dig. 2015 Apr-Jun;28(2):113-6 Authors: Sallum RA, Padrão EM, Szachnowicz S, Seguro FC, Bianchi ET, Cecconello I Abstract BACKGROUND: Association between esophageal achalasia/ gastroesophageal reflux disease (GERD) and cholelithiasis is not clear. Epidemiological data are controversial due to different met... περισσότερα »
Surgical treatment analysis of idiopathic esophageal achalasia.
[image: http:--http://ift.tt/1Q7SQUV] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Surgical treatment analysis of idiopathic esophageal achalasia.* Arq Bras Cir Dig. 2015 Apr-Jun;28(2):98-101 Authors: Aquino JL, Said MM, Pereira DR, Amaral PC, Lima JC, Leandro-Merhi VA Abstract BACKGROUND: Idiopathic esophageal achalasia is an inflammatory disease of unknown origin, characterized by aperistalsis of the esophageal body and failure of the lower esophageal sphincter in response to swallowing, with consequent dysphagia. AIM: To demonstrate the results of surgical therapy i... περισσότερα »
Vicryl patch and fibrin glue as treatment of an esophageal leak.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Vicryl patch and fibrin glue as treatment of an esophageal leak.* Gastrointest Endosc. 2015 Aug;82(2):402 Authors: Ribeiro MS, de Barros RA, Wallace MB PMID: 25922259 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via a.lsfakia on Inoreader http://ift.tt/1TVpQCt via IFTTT
Use of the stag-beetle knife for peroral endoscopic myotomy for achalasia: a novel method for myotomy.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Use of the stag-beetle knife for peroral endoscopic myotomy for achalasia: a novel method for myotomy.* Gastrointest Endosc. 2015 Aug;82(2):401-2 Authors: Bittinger M, Messmann H PMID: 25922252 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via a.lsfakia on Inoreader http://ift.tt/1SFRM86 via IFTTT
Comparison of quality of life and worry of cancer recurrence between endoscopic and surgical treatment for early gastric cancer.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Comparison of quality of life and worry of cancer recurrence between endoscopic and surgical treatment for early gastric cancer.* Gastrointest Endosc. 2015 Aug;82(2):299-307 Authors: Choi JH, Kim ES, Lee YJ, Cho KB, Park KS, Jang BK, Chung WJ, Hwang JS, Ryu SW Abstract BACKGROUND: The quality of life (QOL) of patients who survive early gastric cancer (EGC) is an area of increasing interest. OBJECTIVE: To compare the QOL and degree of worry of cancer recurrence in EGC patients who underwent endoscopic submucosal di... περισσότερα »
Triple A syndrome with a novel indel mutation in the AAAS gene and delayed puberty.
Related Articles *Triple A syndrome with a novel indel mutation in the AAAS gene and delayed puberty.* J Pediatr Endocrinol Metab. 2015 Jul;28(7-8):933-6 Authors: Bustanji H, Sahar B, Huebner A, Ajlouni K, Landgraf D, Hamamy H, Koehler K Abstract Triple A syndrome, formerly known as Allgrove syndrome, is an autosomal recessive disorder characterized clinically by adrenal insufficiency, alacrima, achalasia, and neurological abnormalities. We report a 17-year-old boy presented to the endocrine clinic with delayed puberty and a 4-year's history of fatigue and muscle weakness. He ha... περισσότερα »
Decreased mitochondrial copy numbers in oral squamous cell carcinoma
Decreased mitochondrial copy numbers in oral squamous cell carcinoma: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background Mitochondrial dysfunction and altered respiration have long been suspected to affect the development and progression of cancer. Although quantitative changes in mitochondrial DNA (mtDNA) have been reported in head and neck squamous cell carcinoma (SCC), differences in mtDNA copy numbers between normal and cancerous tissues from same patients have not been assessed. Methods We compared mtDNA copy numbers and expressions of peroxisome prolifera...περισσότερα »
Designing Efficacious Vesicular Stomatitis Virus-Vectored Vaccines Against Ebola Virus.
Designing Efficacious Vesicular Stomatitis Virus-Vectored Vaccines Against Ebola Virus.: Methods Mol Biol. 2016;1403:245-57 Authors: Wong G, Qiu X Abstract Infection with the Ebola virus (EBOV) causes an aggressive hemorrhagic disease in humans and nonhuman primates. Traditional approaches, such as vaccination with inactivated virion preparations, have had limited efficacy, whereas immunization with live-attenuated EBOV is not feasible due to the highly lethal nature of the pathogen. This has necessitated the development of other approaches towards an effective EBOV vaccine. Over ... περισσότερα »
Single-Vector, Single-Injection Recombinant Vesicular Stomatitis Virus Vaccines Against High-Containment Viruses.
Single-Vector, Single-Injection Recombinant Vesicular Stomatitis Virus Vaccines Against High-Containment Viruses.: Methods Mol Biol. 2016;1403:295-311 Authors: Whitt MA, Geisbert TW, Mire CE Abstract There are many avenues for making an effective vaccine against viruses. Depending on the virus these can include one of the following: inactivation of whole virions; attenuation of viruses; recombinant viral proteins; non-replication-competent virus particles; or surrogate virus vector systems such as vesicular stomatitis virus (VSV). VSV is a prototypic enveloped animal virus that ha... περισσότερα »
Intractable hiccups due to herpetic esophagitis
in an immunocompromised patient.: IDCases. 2016;4:34-7 Authors: Harris J, Smith T, Preis J Abstract INTRODUCTION: Herpes virus family's association with visceral lesions is well established. Herpes simplex virus presentations vary based on immune status. Intractable hiccups due to herpes simplex esophagitis, to the best of our knowledge have been described twice in the literature. We present a 68 year-old immunocompromised male with intractable hiccups for 10 months. CASE: 68 year-old male with end-stage renal disease and multiple myeloma presented with coffee ground emesis and h...περισσότερα »
Low-Level Laser Therapy Promoted Aggressive Proliferation and Angiogenesis Through Decreasing of Transforming Growth Factor-β1 and Increasing of Akt/Hypoxia Inducible Factor-1α in Anaplastic Thyroid Cancer.
Low-Level Laser Therapy Promoted Aggressive Proliferation and Angiogenesis Through Decreasing of Transforming Growth Factor-β1 and Increasing of Akt/Hypoxia Inducible Factor-1α in Anaplastic Thyroid Cancer.: Photomed Laser Surg. 2016 Apr 14; Authors: Rhee YH, Moon JH, Choi SH, Ahn JC Abstract OBJECTIVE: We assessed the cause of increased tumor after low-level laser therapy (LLLT) by histological analysis. BACKGROUND DATA: LLLT is a nonthermal phototherapy used in several medical applications, including wound healing, reduction of pain, and amelioration of oral mucositis. We discov...περισσότερα »
Sinus mucosa elevation using Bio-Oss® or Gingistat® collagen sponge
an experimental study in rabbits: Abstract Objective To describe the sequential healing in augmented sinus cavities with deproteinized bovine bone mineral (DBBM) granules or collagen sponges. Material and methods Twenty albino New Zealand rabbits were included in the study. An incision was performed along the midline of the nasal dorsum, and the nasal bone was exposed. Circular bony windows with a diameter of 5 mm were prepared bilaterally. After elevation of the mucosa, the two sites were randomly filled with either DBBM or a collagen sponge. Five animals each were randomly sacrif...περισσότερα »
Marginal healing using Polyetheretherketone as healing abutments
an experimental study in dogs: Abstract Objective To evaluate the marginal soft and hard tissue healing at titanium and Polyetheretherketone (PEEK) healing implant abutments over a 4-month period. Material and Methods In six Labrador dogs, all mandibular premolars and first molars were extracted. After 4 months of healing, flaps were elevated, and two implants were installed at each side of the mandible, one in the premolar and the other in the molar regions. Four different types of healing abutments were positioned on the top of each implant: (i) titanium (Ti); (ii) PEEK material ... περισσότερα »
Exploring the Source of Neural Responses of Different Latencies Obtained from Different Recording Electrodes in Cochlear Implant Users
Exploring the Source of Neural Responses of Different Latencies Obtained from Different Recording Electrodes in Cochlear Implant Users: In this study we measured the electrically evoked compound action potential (ECAP) from different recording electrodes in the cochlea. Under the assumption that different response latencies may be the result of differences in the neural population contributing to the response, we assessed the relationship between neural response latency and spread of excitation. First, we evaluated changes in N1 latency when the recording electrode site was varied. ... περισσότερα »
Early onset hearing loss in autosomal recessive hypophosphatemic rickets caused by loss of function mutation in ENPP1.
Early onset hearing loss in autosomal recessive hypophosphatemic rickets caused by loss of function mutation in ENPP1.: J Pediatr Endocrinol Metab. Authors: Steichen-Gersdorf E, Lorenz-Depiereux B, Strom TM, Shaw NJ Abstract Autosomal recessive hypophosphatemic rickets 2 (ARHR2) is a rare form of renal tubular phosphate wasting disorder. Loss of function mutations of the ecto-nucleotide pyrophosphatase/pyrophosphodiesterase 1 gene (ENPP1) causes a wide spectrum of phenotypes, ranging from lethal generalized arterial calcification of infancy to hypophosphatemic rickets with hyperten...περισσότερα »
The audiological journey and early outcomes of twelve infants with auditory neuropathy spectrum disorder from birth to two years of age.
The audiological journey and early outcomes of twelve infants with auditory neuropathy spectrum disorder from birth to two years of age.: [image: http:--www.tandfonline.com-templates-jsp] Authors: Gardner-Berry K, Purdy SC, Ching TY, Dillon H Abstract OBJECTIVE: To describe the audiological journey of a group of infants with auditory neuropathy spectrum disorder (ANSD) following the fitting of hearing aids, and to investigate the potential benefits of including cortical auditory-evoked potentials (CAEPs) and a measure of functional auditory behaviour during early audiological mana... περισσότερα »
Hearing aid and cochlear implant use in children with hearing loss at three years of age: Predictors of use and predictors of changes in use.
Hearing aid and cochlear implant use in children with hearing loss at three years of age: Predictors of use and predictors of changes in use.: [image: http:--www.tandfonline.com-templates-jsp] Authors: Marnane V, Ching TY Abstract OBJECTIVE: To examine usage patterns of hearing aids and cochlear implants in children up to three years of age, how usage changes longitudinally, and factors associated with device usage. DESIGN: Parent report and Parent's Evaluation of Aural/oral Performance of Children (PEACH) data were obtained at six and twelve months after hearing-aid fitting or c... περισσότερα »
Parents' perspectives on the dilemmas with intervention for infants with auditory neuropathy spectrum disorder: A qualitative study.
Parents' perspectives on the dilemmas with intervention for infants with auditory neuropathy spectrum disorder: A qualitative study.: [image: http:--www.tandfonline.com-templates-jsp] Authors: Uus K, Young A, Day M Abstract OBJECTIVE: This paper explores parental experiences of choices surrounding auditory management and language and communication development for infants and children with auditory neuropathy spectrum disorder (ANSD) in the light of the heterogeneity of condition, a poor evidence base for best outcomes in relation to management options, and the scarcity of data roo... περισσότερα »
The Comparison of Thyroarytenoid Muscle Myectomy and Type II Thyroplasty for Spasmodic Dysphonia.
The Comparison of Thyroarytenoid Muscle Myectomy and Type II Thyroplasty for Spasmodic Dysphonia.: [image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Nomoto M, Tokashiki R, Hiramatsu H, Konomi U, Motohashi R, Sakurai E, Toyomura F, Ueda Y, Inoue S, Tsukahara K, Suzuki M Abstract OBJECTIVE: Surgical treatments for adductor spasmodic dysphonia include bilateral thyroarytenoid muscle myectomy (TAM) and type II thyroplasty (TPII), both of which are commonly performed. The present study aimed to compare the effects of TAM and TPII. STUDY DESIGN: Retrospective study. METHODS: ... περισσότερα »
Time Course of Potassium Nitrate Penetration into the Pulp Cavity and the Effect of Penetration Levels on Tooth Whitening Efficacy
Abstract Objectives To establish time-course of potassium nitrate (PN) penetration into the pulp cavity, and determine whether PN pretreatment would affect whitening efficacy. Materials and Methods Extracted teeth (*n* = 100) were randomized into five groups of 20 specimens each. Relief ACP (Philips Oral Healthcare, Los Angeles, CA, USA) was applied for 0, 5, 15, 30, and 60 minutes for groups 15, respectively. A nitrate/nitrite assay kit was used for colorimetric detection of nitrate. Whitening was performed using a Zoom White Speed system (Philips Oral Healthcare) for 60 minutes. ... περισσότερα »
Effect of the quorum-sensing luxS gene on biofilm formation by Enterococcus faecalis
*Enterococcus faecalis* is the species of bacterium most frequently isolated from the root canals of teeth that exhibit chronic apical periodontitis refractory to endodontic treatment. In this study, we evaluated the effect of the S-ribosylhomocysteine lyase (*luxS*) quorum-sensing gene on *E. faecalis* biofilm formation by constructing a knockout mutant. The biofilms formed by both *E. faecalis* and its *luxS* mutant strain were evaluated using the MTT method. Important parameters that influence biofilm formation, including cell-surface hydrophobicity and the nutrient content of ...περισσότερα »
Comorbid traumatic brain injury and spinal cord injury: Screening validity and effect on outcomes
Archives of Physical Medicine and Rehabilitation from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/20HfOps
Practical application of the revised guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: A case study approach
Nutrition in Clinical Practice from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1TVu0uc
Cost effectiveness of inpatient rehabilitation in patients with brain injury
Clinical Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/20HfOpp
Association of fluid resuscitation initiation within 30 minutes of severe sepsis and septic shock recognition with reduced mortality and length of stay
Annals of Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1TVtZGF
Intravenous fluids in AKI: A mechanistically guided approach
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Acute emergency care and airway management of caustic ingestion in adults: single center observational study
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A practical approach to autonomic dysfunction in patients with headache
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Can children teach their parents cardiopulmonary resuscitation and does teaching influence the retention of their knowledge?
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Emergency department use among Hispanic adults: the role of acculturation
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History, evolution, and importance of emergency endovascular treatment of acute ischemic stroke
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Hemorrhage risk in pediatric patients with multiple intracranial arteriovenous malformations
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Factors associated with long-term functional and psychological outcomes in persons with moderate to severe traumatic brain injury
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Are two or four hands needed for elderly female bystanders to achieve the required chest compression depth during dispatcher-assisted CPR: a randomized controlled trial
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Factors associated to institutionalization and mortality over three years, in elderly people with a hip fracture. An observational study
Maturitas from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/22z2Lpi
Mapping the connectome following traumatic brain injury
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Treatment with prothrombin complex concentrate to enable emergency lumbar puncture in patients receiving vitamin K antagonists
Annals of Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/22z2O4G
Long-term renal outcomes after cisplatin treatment
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Critical access hospital emergency department to quaternary medical center: Successful implementation of an integrated PACS for patient transfers by air and sea
The American Journal of Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/22z2O4C
Impact of spontaneous tumor rupture on prognosis of patients with T4 hepatocellular carcinoma
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Healthcare-associated acute pyelonephritis is associated with inappropriate empiric antibiotic therapy in the emergency department
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Hearing threshold levels for an otologically screened population in Spain.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Hearing threshold levels for an otologically screened population in Spain.* Int J Audiol. 2015 Aug;54(8):499-506 Authors: Rodríguez Valiente A, Roldán Fidalgo A, García Berrocal JR, Ramírez Camacho R Abstract OBJECTIVE: The aim of the present study was to provide thresholds data as a function of age for an otologically normal population in Spain, compared to the current ISO 7029 (2000) standard. DESIGN: A prospective study in an otologically screened population. STUDY SAMPLE: Data was collected from 1175 otologically-normal pe... περισσότερα »
Automated auditory response detection: Further improvement of the statistical test strategy by using progressive test steps of iteration.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Automated auditory response detection: Further improvement of the statistical test strategy by using progressive test steps of iteration.* Int J Audiol. 2015 Aug;54(8):568-72 Authors: Cebulla M, Stürzebecher E Abstract OBJECTIVE: A common testing approach for automated ABR detection is to use a sequential test strategy. Repeated testing increases the error probability for a falsely detected response (Type I error rate). To compensate for this effect, the statistically critical test value must be increased with each test step... περισσότερα »
Parents' perspectives on the dilemmas with intervention for infants with auditory neuropathy spectrum disorder: A qualitative study.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Parents' perspectives on the dilemmas with intervention for infants with auditory neuropathy spectrum disorder: A qualitative study.* Int J Audiol. 2015 Aug;54(8):552-8 Authors: Uus K, Young A, Day M Abstract OBJECTIVE: This paper explores parental experiences of choices surrounding auditory management and language and communication development for infants and children with auditory neuropathy spectrum disorder (ANSD) in the light of the heterogeneity of condition, a poor evidence base for best outcomes in relation to manage... περισσότερα »
[Adhering the scientific integrity and boycotting research misconduct].
*[Adhering the scientific integrity and boycotting research misconduct].* Zhonghua Yi Xue Za Zhi. 2016 Jan 5;96(1):1-3 Authors: Gao R, Chen X PMID: 27074705 [PubMed - in process] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/20Hdw9U via IFTTT
Changing Trends in the Incidence of Thyroid Cancer in the United States.
*Changing Trends in the Incidence of Thyroid Cancer in the United States.* JAMA Otolaryngol Head Neck Surg. 2016 Apr 14; Authors: Morris LG, Tuttle RM, Davies L PMID: 27078686 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/23ASezV via IFTTT
The Delayed Risk Stratification System in the Risk of Differentiated Thyroid Cancer Recurrence.
*The Delayed Risk Stratification System in the Risk of Differentiated Thyroid Cancer Recurrence.* PLoS One. 2016;11(4):e0153242 Authors: Kowalska A, Walczyk A, Pałyga I, Gąsior-Perczak D, Gadawska-Juszczyk K, Szymonek M, Trybek T, Lizis-Kolus K, Szyska-Skrobot D, Mikina E, Hurej S, Słuszniak J, Mężyk R, Góźdź S Abstract CONTEXT: There has been a marked increase in the detection of differentiated thyroid carcinoma (DTC) over the past few years, which has improved the prognosis. However, it is necessary to adjust treatment and monitoring strategies relative to the risk of an unfavo... περισσότερα »
Low-Level Laser Therapy Promoted Aggressive Proliferation and Angiogenesis Through Decreasing of Transforming Growth Factor-β1 and Increasing of Akt/Hypoxia Inducible Factor-1α in Anaplastic Thyroid Cancer.
*Low-Level Laser Therapy Promoted Aggressive Proliferation and Angiogenesis Through Decreasing of Transforming Growth Factor-β1 and Increasing of Akt/Hypoxia Inducible Factor-1α in Anaplastic Thyroid Cancer.* Photomed Laser Surg. 2016 Apr 14; Authors: Rhee YH, Moon JH, Choi SH, Ahn JC Abstract OBJECTIVE: We assessed the cause of increased tumor after low-level laser therapy (LLLT) by histological analysis. BACKGROUND DATA: LLLT is a nonthermal phototherapy used in several medical applications, including wound healing, reduction of pain, and amelioration of oral mucositis. We disco...περισσότερα »
Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors.
*Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors.* JAMA Oncol. 2016 Apr 14; Authors: Nikiforov YE, Seethala RR, Tallini G, Baloch ZW, Basolo F, Thompson LD, Barletta JA, Wenig BM, Al Ghuzlan A, Kakudo K, Giordano TJ, Alves VA, Khanafshar E, Asa SL, El-Naggar AK, Gooding WE, Hodak SP, Lloyd RV, Maytal G, Mete O, Nikiforova MN, Nosé V, Papotti M, Poller DN, Sadow PM, Tischler AS, Tuttle RM, Wall KB, LiVolsi VA, Randolph GW, Ghossein RA Abstract Importance: Although growing evidence... περισσότερα »
Noninvasive Encapsulated Follicular Variant of Papillary Thyroid "Cancer" (or Not): Time for a Name Change.
*Noninvasive Encapsulated Follicular Variant of Papillary Thyroid "Cancer" (or Not): Time for a Name Change.* JAMA Oncol. 2016 Apr 14; Authors: Patel KN PMID: 27077657 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1MxvjxN via IFTTT
MiR-221 Exacerbate Cell Proliferation and Invasion by Targeting TIMP3 in Papillary Thyroid Carcinoma.
*MiR-221 Exacerbate Cell Proliferation and Invasion by Targeting TIMP3 in Papillary Thyroid Carcinoma.* Am J Ther. 2016 Apr 12; Authors: Diao Y, Fu H, Wang Q Abstract MiR-221 is frequently upregulated in papillary thyroid cancer (PTC) tissues and cell lines, and this study was designed to validate the association of miR-221 with PTC proliferation, apoptosis, and migration. We observed that miR-221 suppressed TIMP3 expression by binding to 3' untranslated region of TIMP3 mRNA, and TIMP3 expression was increased with the presence of miR-221 inhibitors; TIMP3 siRNA could reverse the...περισσότερα »
Anatomic Variability of the Upper Mediastinal Lymph Node Level VII.
*Anatomic Variability of the Upper Mediastinal Lymph Node Level VII.* World J Surg. 2016 Apr 13; Authors: Hartl DM, Breuskin I, Mirghani H, Berdelou A, Déandréis D, Pottier E, Borget I, Schlumberger M, Leboulleux S Abstract OBJECTIVE: Lymph node level VII, between the sternal notch and the innominate artery, is a frequent site of lymph node metastases in thyroid cancer. The objective of this study was to determine the cranial-caudal dimensions of level VII in patients undergoing central neck dissection for thyroid cancer and its accessibility through a neck incision only. PATIENTS... περισσότερα »
Surgical treatment of thyroid follicular neoplasms: results of a retrospective analysis of a large clinical series.
*Surgical treatment of thyroid follicular neoplasms: results of a retrospective analysis of a large clinical series.* Endocrine. 2016 Apr 13; Authors: Conzo G, Avenia N, Ansaldo GL, Calò P, De Palma M, Dobrinja C, Docimo G, Gambardella C, Grasso M, Lombardi CP, Pelizzo MR, Pezzolla A, Pezzullo L, Piccoli M, Rosato L, Siciliano G, Spiezia S, Tartaglia E, Tartaglia F, Testini M, Troncone G, Signoriello G Abstract The most appropriate surgical management of "follicular neoplasm/suspicious for follicular neoplasm" lesions (FN), considering their low definitive malignancy rate and the...περισσότερα »
The importance of recognizing a cervical origin of the right subclavian artery.
*The importance of recognizing a cervical origin of the right subclavian artery.* Laryngoscope. 2016 Apr 14; Authors: Machado RA, Moubayed SP, Khorsandi A, Urken ML Abstract Cervical origin of the right subclavian artery is rare and is associated with DiGeorge syndrome. During total thyroidectomy and right lateral neck dissection for metastatic thyroid cancer in a 26-year-old female, the right subclavian artery was found to be cervical in origin. This was identifiable on preoperative computerized tomography. Screening for DiGeorge syndrome and other cardiovascular abnormalities i...περισσότερα »
Diagnosis and Management of Hereditary Thyroid Cancer.
*Diagnosis and Management of Hereditary Thyroid Cancer.* Recent Results Cancer Res. 2016;205:29-44 Authors: Bano G, Hodgson S Abstract Thyroid cancers are largely divided into medullary (MTC) and non-medullary (NMTC) cancers , depending on the cell type of origin. Familial non-medullary thyroid cancer (FNMTC) comprises about 5-15 % of NMTC and is a heterogeneous group of diseases, including both non-syndromic and syndromic forms. Non-syndromic FNMTC tends to manifest papillary thyroid carcinoma , usually multifocal and bilateral . Several high-penetrance genes for FNMTC have been... περισσότερα »
[Outcomes of Surgical Treatment by Modified Transmanubrial Approach].
*[Outcomes of Surgical Treatment by Modified Transmanubrial Approach].* Kyobu Geka. 2016 Mar;69(3):180-3 Authors: Mitsuboshi S, Kanzaki M, Ogihara A, Katagiri S, Yoshiya T, Sakamoto K, Maeda H, Kikkawa T, Isaka T, Oyama K, Murasugi M, Onuki T Abstract OBJECTIVE: The aim of this study is to evaluate the useful and safety of surgical treatment by modified transmanubrial approach(MTA). METHODS: Between January 2000 and May 2014, 10 patients underwent surgical treatment by MTA. Among these patients, we retrospectively reviewed the medical records of 6 patients who had vascular invasion... περισσότερα »
Management of a nonhealing forehead wound with a novel frontalis-pericranial flap and a full-thickness skin graft.
*Management of a nonhealing forehead wound with a novel frontalis-pericranial flap and a full-thickness skin graft.* Laryngoscope. 2016 Apr 14; Authors: Osorio M, Moubayed SP, Weiss E, Urken ML PMID: 27075214 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/20HdsqK via IFTTT
Improving the adoption of thyroid cancer clinical practice guidelines.
*Improving the adoption of thyroid cancer clinical practice guidelines.* Laryngoscope. 2016 Apr 14; Authors: Likhterov I, Tuttle RM, Haser GC, Su HK, Bergman D, Alon EE, Bernet V, Brett E, Cobin R, Dewey EH, Doherty G, Dos Reis LL, Klopper J, Lee SL, Lupo MA, Machac J, Mechanick JI, Milas M, Orloff L, Randolph G, Ross DS, Rowe ME, Smallridge R, Terris D, Tufano RP, Urken ML Abstract OBJECTIVES/HYPOTHESIS: To present an overview of the barriers to the implementation of clinical practice guidelines (CPGs) in thyroid cancer management and to introduce a computer-based clinical suppor... περισσότερα »
Vegetable Oil Intake and Breast Cancer Risk: a Meta-analysis.
Related Articles *Vegetable Oil Intake and Breast Cancer Risk: a Meta-analysis.* Asian Pac J Cancer Prev. 2015;16(12):5125-35 Authors: Xin Y, Li XY, Sun SR, Wang LX, Huang T Abstract BACKGROUND: Total fat intake may be associated with increased risk of breast cancer, and fish oil has been suggested as a protection factor to breast cancer. But the effect of vegetable oils is inconclusive. We aimed to investigate the association with high vegetable oils consumption and breast cancer risk, and evaluated their dose-response relationship. DESIGN: We systematically searched the MEDLINE,...περισσότερα »
Antibodies against Escherichia coli O24 and O56 O-Specific Polysaccharides Recognize Epitopes in Human Glandular Epithelium and Nervous Tissue.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Antibodies against Escherichia coli O24 and O56 O-Specific Polysaccharides Recognize Epitopes in Human Glandular Epithelium and Nervous Tissue.* PLoS One. 2015;10(6):e0129492 Authors: Korzeniowska-Kowal A, Kochman A, Gamian E, Lis-Nawara A, Lipiński T, Seweryn E, Ziółkowski P, Gamian A Abstract Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, contains the O-polysaccharide, which is important to classify bacteria into different O-serological t...περισσότερα »
Proton pump (H+/K+-ATPase) expression in human larynx.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Proton pump (H+/K+-ATPase) expression in human larynx.* Auris Nasus Larynx. 2015 Dec;42(6):458-62 Authors: Stevanović S, Radić R, Kačarević ŽP, Bedeković V, Aras I, Baudoin T, Šoš D, Vrselja Z, Ivkić M Abstract OBJECTIVE: The goal of our study was to investigate and to identify the existence of proton pump in different parts of larynx. The presence of acidic content in this area is known to be connected to several laryngeal diseases. It is mostly developed by upward recurrence of acidic gastric content, but there... περισσότερα »
Mucinous Balls Tangled With Mesothelial Cells and MUC2-Positive Cancer Cells in the Ascites of Pseudomyxoma Peritonei
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Pseudomyxoma peritonei (PMP) is characterized by extensive mucinous ascites following rupture of mucinous neoplasms of an intra-abdominal origin, and contain secreted gel-forming mucins such as MUC2 and MUC5AC. We encountered a 66-year-old Japanese man complaining of abdominal distension. Ascites at the site was gelatinous upon gross examination, and needle aspirate smears showed histiocytes and many mucinous balls wrapped in spindle cells, which were positive for vimentin, pan-cytokeratin, and podoplanin. The cell block showed several adenocarcinoma clusters, which were positive ...περισσότερα »
Cytologic Differential Diagnosis of Malignant Mesothelioma and Reactive Mesothelial Cells With FISH Analysis of p16
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Background Mesothelioma patients often present with serosal effusions, which are ideal for cytopathological diagnoses. However, the morphological overlap between malignant and benign mesothelial proliferation can make a conclusive cytological diagnosis of mesothelioma elusive because immunohistochemical staining does not discriminate definitively between the two in this setting. p16 is deleted in up to 80% of pleural mesotheliomas. The aim of this study was to establish the correlation between the p16 deletion status of the cell block with that of its corresponding tumor using flu...περισσότερα »
The scaling of postcranial muscles in cats (Felidae) II: hindlimb and lumbosacral muscles
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Abstract In quadrupeds the musculature of the hindlimbs is expected to be responsible for generating most of the propulsive locomotory forces, as well as contributing to body support by generating vertical forces. In supporting the body, postural changes from crouched to upright limbs are often associated with an increase of body mass in terrestrial tetrapods. However, felids do not change their crouched limb posture despite undergoing a 300-fold size increase between the smallest and largest extant species. Here, we test how changes in the muscle architecture (masses and lengths ... περισσότερα »
Extrusion versus diffusion: mechanisms for recovery from sodium loads in mouse CA1 pyramidal neurons
Abstract Excitatory activity is accompanied by sodium influx into neurones due to opening of voltage- and ligand-activated channels. Recovery from resulting sodium transients has mainly been attributed to the Na+/K+-ATPase (NKA). Because sodium ions are highly mobile, diffusion could provide an additional pathway. We tested this in hippocampal neurones using whole-cell patch-clamp recordings and sodium imaging. Somatic sodium transients induced by local glutamate application recovered at a maximum rate of 8 mM min−1 (∼0.03 mM min−1μm−2). Somatic sodium extrusion was accelerated at ...περισσότερα »
Active subthreshold dendritic conductances shape the local field potential
Abstract The main contribution to the local field potential (LFP) is thought to stem from synaptic input to neurons and the ensuing subthreshold dendritic processing. The role of active dendritic conductances in shaping the LFP has received little attention, even though such ion channels are known to affect the subthreshold neuron dynamics. Here we used a modelling approach to investigate the effects of subthreshold dendritic conductances on the LFP. Using a biophysically detailed, experimentally constrained model of a cortical pyramidal neuron, we identified conditions under which ... περισσότερα »
TRPA1 channels: molecular sentinels of cellular stress and tissue damage
TRPA1 is a non-selective cation channel expressed in mammalian peripheral pain receptors, with a major role in chemonociception. TRPA1 has also been implicated in noxious cold and mechanical pain sensation. TRPA1 has an ancient origin and plays important functions in lower organisms, including thermotaxis, mechanotransduction and modulation of lifespan. Here we highlight TRPA1 role as a multipurpose sensor of harmful signals, including toxic bacterial products, UV light and sensor for stress and tissue damage. Sensing roles span beyond the peripheral nervous system to include major...περισσότερα »
Cellular electrophysiological principles that modulate secretion from synovial fibroblasts
Abstract Rheumatoid arthritis (RA) is a progressive disease that affects both pediatric and adult populations. The cellular basis for RA has been investigated extensively using animal models, human tissues and isolated cells in culture. However, many aspects of its etiology and molecular mechanisms remain unknown (McInnes & Schett, 2011). Some of the electrophysiological principles that regulate secretion of essential lubricants (hyaluronan and lubricin) and cytokines from synovial fibroblasts (FLS) have been identidied. Data sets describing the main types of ion channels that are ... περισσότερα »
Preejection period can be calculated using R peak instead of Q
Abstract Preejection period (PEP) is a common measure of sympathetic nervous system activation in psychophysiological research, which makes it important to measure reliably for as many participants as possible. PEP is typically calculated as the interval between the onset or peak of the electrocardiogram Q wave and the impedance cardiography B point, but the Q wave can lack clear definition and even its peak is not visible for all participants. We thus investigated the feasibility of using the electrocardiogram R wave peak (Rpeak) instead of Q because it can be consistently identif... περισσότερα »
Blood pressure and the perception of illusive pain
Abstract Numerous studies have documented an inverse relationship between blood pressure and sensitivity to experimental nociceptive stimulation. The present study aimed to investigate possible associations between blood pressure and the occurrence and intensity of paradoxical pain induced by the thermal grill paradigm. Thirty-one healthy subjects were stimulated three times for 1 min with the nonnoxious temperatures of 15°C and 41°C set at the interlaced cold and warm bars of a water bath-driven thermal grill. Blood pressure and heart rate were recorded concomitantly. On account of...περισσότερα »
Theta EEG neurofeedback benefits early consolidation of motor sequence learning
Abstract Procedural learning is subject to consolidation processes believed to depend on the modulation of functional connections involved in representing the acquired skill. While sleep provides the most commonly studied framework for such consolidation processes, posttraining modulation of oscillatory brain activity may also impact on plasticity processes. Under the hypothesis that consolidation of motor learning is associated with theta band activity, we used EEG neurofeedback (NFB) to enable participants to selectively increase either theta or beta power in their EEG spectra fo... περισσότερα »
40-Hz oscillations underlying perceptual binding in young and older adults
Abstract Auditory object perception requires binding of elementary features of complex stimuli. Synchronization of high-frequency oscillation in neural networks has been proposed as an effective alternative to binding via hard-wired connections because binding in an oscillatory network can be dynamically adjusted to the ever-changing sensory environment. Previously, we demonstrated in young adults that gamma oscillations are critical for sensory integration and found that they were affected by concurrent noise. Here, we aimed to support the hypothesis that stimulus evoked auditory ... περισσότερα »
Preejection period can be calculated using R peak instead of Q
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 53 δευτερόλεπτα
Abstract Preejection period (PEP) is a common measure of sympathetic nervous system activation in psychophysiological research, which makes it important to measure reliably for as many participants as possible. PEP is typically calculated as the interval between the onset or peak of the electrocardiogram Q wave and the impedance cardiography B point, but the Q […]
Blood pressure and the perception of illusive pain
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 53 δευτερόλεπτα
Abstract Numerous studies have documented an inverse relationship between blood pressure and sensitivity to experimental nociceptive stimulation. The present study aimed to investigate possible associations between blood pressure and the occurrence and intensity of paradoxical pain induced by the thermal grill paradigm. Thirty-one healthy subjects were stimulated three times for 1 min with the nonnoxious […]
Theta EEG neurofeedback benefits early consolidation of motor sequence learning
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 53 δευτερόλεπτα
Abstract Procedural learning is subject to consolidation processes believed to depend on the modulation of functional connections involved in representing the acquired skill. While sleep provides the most commonly studied framework for such consolidation processes, posttraining modulation of oscillatory brain activity may also impact on plasticity processes. Under the hypothesis that consolidation of motor learning […]
40-Hz oscillations underlying perceptual binding in young and older adults
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 53 δευτερόλεπτα
Abstract Auditory object perception requires binding of elementary features of complex stimuli. Synchronization of high-frequency oscillation in neural networks has been proposed as an effective alternative to binding via hard-wired connections because binding in an oscillatory network can be dynamically adjusted to the ever-changing sensory environment. Previously, we demonstrated in young adults that gamma oscillations […]
Effect of the quorum-sensing luxS gene on biofilm formation by Enterococcus faecalis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 53 δευτερόλεπτα
Enterococcus faecalis is the species of bacterium most frequently isolated from the root canals of teeth that exhibit chronic apical periodontitis refractory to endodontic treatment. In this study, we evaluated the effect of the S-ribosylhomocysteine lyase (luxS) quorum-sensing gene on E. faecalis biofilm formation by constructing a knockout mutant. The biofilms formed by both E. […]
Solvent-promoted Catalyst-free N-Formylation of Amines Using Carbon Dioxide under Ambient Conditions
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 53 δευτερόλεπτα
Chem. Commun., 2016, Accepted Manuscript DOI: 10.1039/C6CC01234E, Communication Hui Lv, Qi Xing, Chengtao yue, Zi Qiang Lei, fuwei li An unprecedented catalyst-free formylation of amines with CO2 and hydrosilanes was developed. Solvent plays a vital role in promoting the interaction of amines with hydrosilanes and subsequent CO2 insertion, thus… The content of this RSS Feed […]
Onwettig advies van de HRHB belet herstelvordering niet
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 53 δευτερόλεπτα
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1Sj8WhR via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SPdMhh via IFTTT
The Panama Papers and the International Battle Against Tax Havens: Lessons for the EU
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 53 δευτερόλεπτα
The collaborative publication of the Panama Papers in the first week of April revealed in an unprecdented level tax evasion via the Panamanian lawyer’s office Mossack Fonseca – this article examines lessons for the EU. from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1QbCdDF via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader […]
Wie niet weg is, is gezien: ondersteuningsstrategieën van praktijkwerkers
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 53 δευτερόλεπτα
Deze bijdrage rapporteert over een recente studie die kadert binnen het Vlaams Armoedesteunpunt (VLAS) en ontwikkeld werd vanuit de Vakgroep Sociaal Werk en Sociale Pedagogiek (UGent). We bevroegen praktijkwerkers die als ondersteunend werden aangeduid door ouders met jonge kinderen in armoede. Via open diepte-interviews gingen we daarbij na hoe deze ondersteuningspraktijken ontwikkeld worden in het […]
What families in poverty consider supportive: welfare strategies of parents with young children in relation to (child and family) social work
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 53 δευτερόλεπτα
In current European Welfare states, Child and Family Social Work has been assigned a pivotal role in constructing a route out of (child) poverty. The direction, processes and outcomes of these interventions are, however, rarely negotiated with the families involved. Based on a retrospective biographical research with parents of young children who experienced financial difficulties […]
Gender-specific analysis of outcomes from endoscopic sinus surgery for chronic rhinosinusitis
Background Women electing endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) report higher symptom burden but have lower computed tomography (CT) scores. Gender-specific analysis of outcomes from ESS therefore merits further study. The objective of this work was to study gender-specific differences in outcomes from ESS for CRS by analyzing preoperative and postoperative 22-item Sino-Nasal… Continue reading Gender-specific analysis of outcomes from endoscopic sinus surgery for chronic rhinosinusitis
Improvements in psychological dysfunction after endoscopic sinus surgery for patients with chronic rhinosinusitis
Background Psychological dysfunction is highly prevalent among patients with chronic rhinosinusitis (CRS). Previous study has identified various measures of anxiety and depression as predictors of quality-of-life outcomes following endoscopic sinus surgery (ESS). Psychological dysfunction scores, as measured by the 22-item Sino-Nasal Outcome Test (SNOT-22), have been found to influence treatment decision making in CRS. This… Continue reading Improvements in psychological dysfunction after endoscopic sinus surgery for patients with chronic rhinosinusitis
The Effect of Microcirculatory Flow on Oscillating Gradient Diffusion MRI and Diffusion Encoding with Dual-Frequency Orthogonal Gradients (DEFOG)
Purpose We investigated the effect of microcirculatory flow on oscillating gradient spin echo (OGSE) diffusion MRI at low b-values and developed a diffusion preparation method called diffusion encoding with dual-frequency orthogonal gradients (DEFOG) to suppress the effect. Methods Compared to conventional OGSE sequences, DEFOG adds a pulsed gradient that is orthogonal to the oscillating gradient… Continue reading The Effect of Microcirculatory Flow on Oscillating Gradient Diffusion MRI and Diffusion Encoding with Dual-Frequency Orthogonal Gradients (DEFOG)
Rapid in vivo detection of rat spinal cord injury with double-diffusion-encoded magnetic resonance spectroscopy
Purpose Diffusion-weighted imaging is a common experimental tool for evaluating spinal cord injury (SCI), yet it suffers from complications that decrease its clinical effectiveness. The most commonly used technique, diffusion tensor imaging (DTI), is often confounded by effects of edema accompanying acute SCI, limiting its sensitivity to the important functional status marker of axonal integrity.… Continue reading Rapid in vivo detection of rat spinal cord injury with double-diffusion-encoded magnetic resonance spectroscopy
Pharmaceutics, Vol. 8, Pages 13: Timing of Administration: For Commonly-Prescribed Medicines in Australia
Chronotherapy involves the administration of medication in coordination with the body’s circadian rhythms to maximise therapeutic effectiveness and minimise/avoid adverse effects. The aim of this study is to investigate the “time of administration” recommendations on chronotherapy for commonly-prescribed medicines in Australia. This study also aimed to explore the quality of information on the timing of… Continue reading Pharmaceutics, Vol. 8, Pages 13: Timing of Administration: For Commonly-Prescribed Medicines in Australia
Parents’ perspectives on the dilemmas with intervention for infants with auditory neuropathy spectrum disorder: A qualitative study.
Related Articles Parents’ perspectives on the dilemmas with intervention for infants with auditory neuropathy spectrum disorder: A qualitative study. Int J Audiol. 2015 Aug;54(8):552-8 Authors: Uus K, Young A, Day M Abstract OBJECTIVE: This paper explores parental experiences of choices surrounding auditory management and language and communication development for infants and children with auditory neuropathy… Continue reading Parents’ perspectives on the dilemmas with intervention for infants with auditory neuropathy spectrum disorder: A qualitative study.
Hearing aid and cochlear implant use in children with hearing loss at three years of age: Predictors of use and predictors of changes in use.
Related Articles Hearing aid and cochlear implant use in children with hearing loss at three years of age: Predictors of use and predictors of changes in use. Int J Audiol. 2015 Aug;54(8):544-51 Authors: Marnane V, Ching TY Abstract OBJECTIVE: To examine usage patterns of hearing aids and cochlear implants in children up to three years… Continue reading Hearing aid and cochlear implant use in children with hearing loss at three years of age: Predictors of use and predictors of changes in use.
The audiological journey and early outcomes of twelve infants with auditory neuropathy spectrum disorder from birth to two years of age.
Related Articles The audiological journey and early outcomes of twelve infants with auditory neuropathy spectrum disorder from birth to two years of age. Int J Audiol. 2015 Aug;54(8):524-35 Authors: Gardner-Berry K, Purdy SC, Ching TY, Dillon H Abstract OBJECTIVE: To describe the audiological journey of a group of infants with auditory neuropathy spectrum disorder (ANSD)… Continue reading The audiological journey and early outcomes of twelve infants with auditory neuropathy spectrum disorder from birth to two years of age.
Differential amplicons (ΔAmp)-a new molecular method to assess RNA integrity.
Differential amplicons (ΔAmp)-a new molecular method to assess RNA integrity. Biomol Detect Quantif. 2016 Jan;6:4-12 Authors: Björkman J, Švec D, Lott E, Kubista M, Sjöback R Abstract Integrity of the mRNA in clinical samples has major impact on the quality of measured expression levels. This is independent of the measurement technique being next generation sequencing… Continue reading Differential amplicons (ΔAmp)-a new molecular method to assess RNA integrity.
Differential amplicons (ΔAmp)-a new molecular method to assess RNA integrity.
Differential amplicons (ΔAmp)-a new molecular method to assess RNA integrity. Biomol Detect Quantif. 2016 Jan;6:4-12 Authors: Björkman J, Švec D, Lott E, Kubista M, Sjöback R Abstract Integrity of the mRNA in clinical samples has major impact on the quality of measured expression levels. This is independent of the measurement technique being next generation sequencing… Continue reading Differential amplicons (ΔAmp)-a new molecular method to assess RNA integrity.
Comparison of Abstinence Rates of Smoking Cessation Medications among Obese Smokers
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
2016-04-15T03-23-53Z *Source:* Journal of Behavioral Health Mo Yang, Hua Chen, Michael L Johnson, Ekere J Essien, Ronald J Peters, Xin Wang, Susan Abughosh. Although both varenicline and bupropion have been reported to be effective in terms of increasing the abstinence rate, while previous literature among adults reports better abstinence with varenicline compared to bupropion, our findings among obese smokers indicate no difference in abstinence for those using bupropion compared to those using varenicline. from Scope via xlomafota13 on Inoreader http://ift.tt/1RYgODy via IFTTT
quality of care; +120 new citations
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
120 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: quality of care These pubmed results were generated on 2016/04/15 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text […]
Hot off the press: read our latest research paper on the role of confirmatory biopsy in #pCa https://t.co/QxjvLgTSxj https://t.co/4vFiewt5UB
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Hot off the press: read our latest research paper on the role of confirmatory biopsy in #pCa https://t.co/QxjvLgTSxj https://t.co/4vFiewt5UB from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/720916989913526272 via IFTTT
@mishagajewski @HealthNewsRevu The above-referenced headline might provide a Friday smile… theological questions aside, of course…
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
@mishagajewski @HealthNewsRevu The above-referenced headline might provide a Friday smile… theological questions aside, of course… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/720910253378945024 via IFTTT
CRUK researchers announce that cancer cells turn healthy cells to the ‘dark side’. https://t.co/1B9c6FsKOR https: //t.co/CDPhZvdtEe
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
CRUK researchers announce that cancer cells turn healthy cells to the ‘dark side’. https://t.co/1B9c6FsKOR https://t.co/CDPhZvdtEe from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/720908718595031040 via IFTTT
Issue Information – Masthead
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Nomenclature of genetic movement disorders: Recommendations of the international Parkinson and movement disorder society task force
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
ABSTRACT The system of assigning locus symbols to specify chromosomal regions that are associated with a familial disorder has a number of problems when used as a reference list of genetically determined disorders,including (I) erroneously assigned loci, (II) duplicated loci, (III) missing symbols or loci, (IV) unconfirmed loci and genes, (V) a combination of causative […]
Issue Information – Table of Contents
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/23Kkkp1 via IFTTT
Movement Disorders: Volume 31, Number 4, April 2016
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Oliver Sacks, MD, 1933–2015
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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New IR imaging modalities for cancer detection and for intra-cell chemical mapping with a sub-diffraction mid-IR s-SNOM.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
New IR imaging modalities for cancer detection and for intra-cell chemical mapping with a sub-diffraction mid-IR s-SNOM. Faraday Discuss. 2016 Apr 14; Authors: Amrania H, Drummond L, Coombes RC, Shousha S, Woodley-Barker L, Weir K, Hart W, Carter I, Phillips CC Abstract We present two new modalities for generating chemical maps. Both are mid-IR based […]
Parents' perspectives on the dilemmas with intervention for infants with auditory neuropathy spectrum disorder: A qualitative study.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Parents' perspectives on the dilemmas with intervention for infants with auditory neuropathy spectrum disorder: A qualitative study.* Int J Audiol. 2015 Aug;54(8):552-8 Authors: Uus K, Young A, Day M Abstract OBJECTIVE: This paper explores parental experiences of choices surrounding auditory management and language and communication development for infants and children with auditory neuropathy spectrum disorder (ANSD) in the light of the heterogeneity of condition, a poor evidence base for best outcomes in relation to manage... περισσότερα »
Hearing aid and cochlear implant use in children with hearing loss at three years of age: Predictors of use and predictors of changes in use.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Hearing aid and cochlear implant use in children with hearing loss at three years of age: Predictors of use and predictors of changes in use.* Int J Audiol. 2015 Aug;54(8):544-51 Authors: Marnane V, Ching TY Abstract OBJECTIVE: To examine usage patterns of hearing aids and cochlear implants in children up to three years of age, how usage changes longitudinally, and factors associated with device usage. DESIGN: Parent report and Parent's Evaluation of Aural/oral Performance of Children (PEACH) data were obtained at six and twe... περισσότερα »
The audiological journey and early outcomes of twelve infants with auditory neuropathy spectrum disorder from birth to two years of age.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *The audiological journey and early outcomes of twelve infants with auditory neuropathy spectrum disorder from birth to two years of age.* Int J Audiol. 2015 Aug;54(8):524-35 Authors: Gardner-Berry K, Purdy SC, Ching TY, Dillon H Abstract OBJECTIVE: To describe the audiological journey of a group of infants with auditory neuropathy spectrum disorder (ANSD) following the fitting of hearing aids, and to investigate the potential benefits of including cortical auditory-evoked potentials (CAEPs) and a measure of functional audito... περισσότερα »
Electrophysiologic vestibular evaluation in type 2 diabetic and prediabetic patients: Air conduction ocular and cervical vestibular evoked myogenic potentials.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Electrophysiologic vestibular evaluation in type 2 diabetic and prediabetic patients: Air conduction ocular and cervical vestibular evoked myogenic potentials.* Int J Audiol. 2015 Aug;54(8):536-43 Authors: Konukseven O, Polat SB, Karahan S, Konukseven E, Ersoy R, Cakir B, Kutluhan A, Aksoy S Abstract OBJECTIVE: Chronically increased blood glucose levels may affect the vestibular system by damaging cells and neural structures in diabetes mellitus (DM). We aimed to search the effects of neurovascular degeneration on the vesti... περισσότερα »
Early onset hearing loss in autosomal recessive hypophosphatemic rickets caused by loss of function mutation in ENPP1.
Related Articles *Early onset hearing loss in autosomal recessive hypophosphatemic rickets caused by loss of function mutation in ENPP1.* J Pediatr Endocrinol Metab. 2015 Jul;28(7-8):967-70 Authors: Steichen-Gersdorf E, Lorenz-Depiereux B, Strom TM, Shaw NJ Abstract Autosomal recessive hypophosphatemic rickets 2 (ARHR2) is a rare form of renal tubular phosphate wasting disorder. Loss of function mutations of the ecto-nucleotide pyrophosphatase/pyrophosphodiesterase 1 gene (ENPP1) causes a wide spectrum of phenotypes, ranging from lethal generalized arterial calcification of infan...περισσότερα »
Safety and risk of superselective transcatheter arterial embolization for acute lower gastrointestinal hemorrhage with N-butyl cyanoacrylate: angiographic and colonoscopic evaluation
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Journal of Vascular and Interventional Radiology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1SPg8N0 via IFTTT
Effect of electroacupuncture and herbal cake-partitioned moxibustion on anxiety and depression in patients with crohn's disease in remission
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Journal of Acupuncture and Tuina Science from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1RYaAmW via IFTTT
Economic evaluation of fecal microbiota transplantation for the treatment of recurrent Clostridium difficile infection in Australia
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Journal of Gastroenterology and Hepatology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1SPg8ww via IFTTT
