The application of p16 immunohistochemistry in diagnostic pathology
Practical issues in via Human Pathology Publication date: May 2016 *Source:*Human Pathology, Volume 51 Author(s): Aparna Mahajan The p16 tumor suppressor gene (CDKN2A) is a member of the INK4 class of cell cycle inhibitors and is located on chromosome 9p21. The p16 protein binds to cyclin-dependent kinases 4 and 6 and maintains the retinoblastoma gene product in its hypophosphorylated state, which in turn binds to E2F transcription factor and prevents cell cycle progression. Expression of p16 protein is increased in aging cells. Immunohistochemistry for p16ink4a is most widely used a... περισσότερα »
Prognostic impact of pathological response to neoadjuvant chemotherapy followed by definitive surgery in sinonasal squamous cell carcinoma
Prognostic impact of pathological response to neoadjuvant chemotherapy followed by definitive surgery in sinonasal squamous cell carcinoma: [image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background The significance of neoadjuvant chemotherapy followed by definitive surgery for sinonasal squamous cell carcinoma (SCC) was investigated using surgical specimens. Methods Surgery was performed in 58 patients, including 43 patients who had received neoadjuvant chemotherapy. The pathological response was classified as grades 0 (no effect), 1 (slight effect), 2 (moderate effec... περισσότερα »
Protein expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 in young patients with oral squamous cellcarcinoma
Protein expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 in young patients with oral squamous cellcarcinoma via Oral and Maxillofacial Surgery Publication date: Available online 2 March 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): E. Kaminagakura, A. Caris, C. Coutinho-Camillo, F.A. Soares, A. Takahama-Júnior, L.P. Kowalski The purpose of this study was to evaluate the expression of the enzymes involved in the biotransformation of tobacco and alcohol. A study group of 41 young patients (≤40 years old) with oralsquamous cell carcinoma (OSCC) was comp... περισσότερα »
Reduced DNA double-strand break repair capacity and risk of squamous cell carcinoma of the head and neck
—A case-control study via ScienceDirect Publication: DNA Repair Publication date: Available online 2 March 2016 *Source:*DNA Repair Author(s): Zhensheng Liu, Hongliang Liu, Fengqin Gao, Kristina R. Dahlstrom, Erich M. Sturgis, Qingyi Wei Tobacco smoke and alcohol use play important roles in the etiology of squamous cell carcinoma of the head and neck (SCCHN). Smoking causes DNA damage, including double-strand DNA breaks (DSBs), that leads to carcinogenesis. To test the hypothesis that suboptimal DSB repair capacity is associated with risk of SCCHN, we applied a flow cytometry-based met... περισσότερα »
Identification of a predictive factor for distant metastasis in esophageal squamous cell carcinoma after definitive chemoradiotherapy
Identification of a predictive factor for distant metastasis in esophageal squamous cell carcinoma after definitive chemoradiotherapy: Abstract Background and purposeDistant metastasis (DM) after definitive chemoradiotherapy has not been a focus of research in esophageal carcinoma. At present, local–regional control is improving following advances in salvage treatments after definitive chemoradiotherapy. There is a need to focus on suppressing the development of DM. The aim of this study was to identify pre-treatment factors associated with DM after definitive chemoradiotherapy.... περισσότερα »
Extensive Squamous Cell Carcinoma of the Skin Related to Use of Sorafenib for Treatment of FLT3-Mutant Acute Myeloid Leukemia DIAGNOSIS IN ONCOLOGY
Extensive Squamous Cell Carcinoma of the Skin Related to Use of Sorafenib for Treatment of FLT3-Mutant Acute Myeloid Leukemia [DIAGNOSIS IN ONCOLOGY]: from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1nkBf0Y via IFTTT
FGFR1 in head and neck squamous cell carcinoma
FGFR1 in head and neck squamous cell carcinoma: Purpose:FGFR1 (fibroblast growth factor receptor 1) is a promising therapeutic target in multiple tumors, including head and neck squamous cell carcinoma (HNSCC). However, resistance remains a major setback. In this study we have investigated the prognostic value of FGFR1 expression in HNSCC, the therapeutic relevance of targeting… Continue reading FGFR1 in head and neck squamous cell carcinoma
CLAT1 and ASCT2 in patients with surgically resected esophageal squamous cell carcinoma
Clinicopathological significance of LAT1 and ASCT2 in patients with surgically resected esophageal squamous cell carcinoma: Background Amino acid transporters are highly expressed in various human cancers. L-type amino acid transporter 1 (LAT1) and system alanine-serine-cysteine amino acid transporter-2 (ASCT2) play a crucial role in tumor progression and survival. However, the clinicopathological significance of these transporters… Continue reading CLAT1 and ASCT2 in patients with surgically resected esophageal squamous cell carcinoma
Sex hormones and the risk of keratinocyte cancers among women
Sex hormones and the risk of keratinocyte cancers among women in the United States: A population-based case-control study: Abstract Men are at a higher risk of developing both squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) than women, but there is emerging evidence that women may be experiencing greater increases in the incidence rates… Continue reading Sex hormones and the risk of keratinocyte cancers among women
Autoimmune hemolytic anemia induced by anti-PD-1 therapy in metastatic melanoma
Autoimmune hemolytic anemia induced by anti-PD-1 therapy in metastatic melanoma: We report the occurrence of autoimmune hemolytic anemia in a patient receiving the anti-PD-1 monoclonal antibody, nivolumab, for metastatic melanoma in the presence of known red cell alloantibodies, despite having received prior ipilimumab without evidence of hemolysis. The patient had a history of multiple red… Continue reading Autoimmune hemolytic anemia induced by anti-PD-1 therapy in metastatic melanoma
Increased risk of melanoma in patients with chronic lymphocytic leukaemia
Increased risk of melanoma in patients with chronic lymphocytic leukaemia: systematic review and meta-analysis of cohort studies: An increased risk of melanoma has been variously reported in patients with chronic lymphocytic leukaemia (CLL), analogous with other immunosuppressed populations. To fully assess this association, we performed a systematic review and meta-analysis of available evidence from observational… Continue reading Increased risk of melanoma in patients with chronic lymphocytic leukaemia
Ipilimumab in anti-PD1 refractory metastatic melanoma
Ipilimumab in anti-PD1 refractory metastatic melanoma: a report of eight cases: Targeted therapy and immunotherapy in metastatic melanoma have led to a marked improvement in patients’ survival and their quality of life. Although there are data on anti-programmed-death-receptor-1 (anti-PD1) after ipilimumab, only few data are available on ipilimumab following anti-PD1 as the first-line treatment. The… Continue reading Ipilimumab in anti-PD1 refractory metastatic melanoma
The Troubling Trichotomy 10 Years Later–Where Are We Now?
A decade ago, «Nutrition Support and The Troubling Trichotomy: A Call To Action» was published in this journal, identifying existing conflicts among technological, ethical, and legal aspects of nutrition support therapy, particularly in terminal or end-of-life situations. Over the past 10 years, the American Society for Parenteral and Enteral Nutrition and others have responded to… Continue reading The Troubling Trichotomy 10 Years Later–Where Are We Now?
Periodic acid–Schiff-positive loops and networks as a prognostic factor in oral mucosal melanoma
Periodic acid–Schiff-positive loops and networks as a prognostic factor in oral mucosal melanoma: Abstract The prognostic factors of oral mucosal melanoma (OMM), a rare and aggressive neoplasm, remain to be determined. The aim of this study is to investigate the prognostic significance of vasculogenic mimicry in OMM. The clinical data of 62 patients with primary… Continue reading Periodic acid–Schiff-positive loops and networks as a prognostic factor in oral mucosal melanoma
Prognostic markers and tumour growth kinetics in melanoma patients progressing on vemurafenib
Prognostic markers and tumour growth kinetics in melanoma patients progressing on vemurafenib: The BRAF inhibitor vemurafenib is an effective drug in patients with BRAF mutant metastatic melanoma, but resistance occurs after a median of 6 months. The anti-CTLA4-antibody, ipilimumab, is a standard first-line and second-line treatment option in Europe, with a median time to response… Continue reading Prognostic markers and tumour growth kinetics in melanoma patients progressing on vemurafenib
Bloodless surgery to the scalp
*New technique for bloodless surgery to the scalp: Skin cancers such as malignant melanoma, squamous cell carcinoma, and basal cell carcinoma are common on the scalp,1 and the usual treatment is wide local excision with disease- free margins. Margins vary depending on the type of cancer, the size and depth of invasion, and the cytological findings, as described in the British Association of Dermatology guidelines.2 * Carbon dioxide laser in *scalp *tumor *surgery* *V Sacchini, GF Lovo, N Arioli, M Nava… - Lasers in surgery …, 1984 - Wiley Online Library* *... The versatility o...περισσότερα »
Efficacy and safety of vinorelbine in heavily pretreated recurrent/metastatic head and neck squamous cell carcinoma patients
Efficacy and safety of vinorelbine in heavily pretreated recurrent/metastatic head and neck squamous cell carcinoma patients: The aim of this study was to evaluate the efficacy and tolerance of vinorelbine as a single agent in the treatment of recurrent/metastatic head and neck squamous cell carcinoma. Patients were treated with oral or intravenous vinorelbine according to the pluridisciplinary tumor board’s decision. Efficacy and safety outcomes were analyzed retrospectively. Twenty-three patients were included in the study. Sixteen patients (69%) had received at least two previou... περισσότερα »
Extensive Squamous Cell Carcinoma of the Skin Related to Use of Sorafenib for Treatment of FLT3-Mutant Acute Myeloid Leukemia [DIAGNOSIS IN ONCOLOGY]
Extensive Squamous Cell Carcinoma of the Skin Related to Use of Sorafenib for Treatment of FLT3-Mutant Acute Myeloid Leukemia [DIAGNOSIS IN ONCOLOGY]: [image: F1.small.gif]
FGFR1 in head and neck squamous cell carcinoma
FGFR1 in head and neck squamous cell carcinoma: Purpose:FGFR1 (fibroblast growth factor receptor 1) is a promising therapeutic target in multiple tumors, including head and neck squamous cell carcinoma (HNSCC). However, resistance remains a major setback. In this study we have investigated the prognostic value of FGFR1 expression in HNSCC, the therapeutic relevance of targeting FGFR with AZD4547, and potential resistant mechanisms. Experimental Design:Immunohistochemistry and fluorescence in situ hybridization were applied on tissue microarrays to investigate FGFR1 protein expressi... περισσότερα »
CLAT1 and ASCT2 in patients with surgically resected esophageal squamous cell carcinoma
Clinicopathological significance of LAT1 and ASCT2 in patients with surgically resected esophageal squamous cell carcinoma: Background Amino acid transporters are highly expressed in various human cancers. L-type amino acid transporter 1 (LAT1) and system alanine-serine-cysteine amino acid transporter-2 (ASCT2) play a crucial role in tumor progression and survival. However, the clinicopathological significance of these transporters in patients with esophageal squamous cell carcinoma (ESCC) remains unclear. Methods One hundred and fifty-seven patients with surgically resected ESCC we... περισσότερα »
Sex hormones and the risk of keratinocyte cancers among women
Sex hormones and the risk of keratinocyte cancers among women in the United States: A population-based case-control study: Abstract Men are at a higher risk of developing both squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) than women, but there is emerging evidence that women may be experiencing greater increases in the incidence rates of these malignancies than men. One possible explanation is the expanding use of sex steroids among women, although only a few studies have examined this hypothesis. As part of a population-based, case-control study of women in New Hamp...περισσότερα »
Autoimmune hemolytic anemia induced by anti-PD-1 therapy in metastatic melanoma
Autoimmune hemolytic anemia induced by anti-PD-1 therapy in metastatic melanoma: We report the occurrence of autoimmune hemolytic anemia in a patient receiving the anti-PD-1 monoclonal antibody, nivolumab, for metastatic melanoma in the presence of known red cell alloantibodies, despite having received prior ipilimumab without evidence of hemolysis. The patient had a history of multiple red cell alloantibodies and a positive direct antiglobulin test, identified at the time of a prior transfusion, which occurred before treatment with ipilimumab. The patient developed symptomatic wa...περισσότερα »
The Troubling Trichotomy 10 Years Later–Where Are We Now?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
A decade ago, «Nutrition Support and The Troubling Trichotomy: A Call To Action» was published in this journal, identifying existing conflicts among technological, ethical, and legal aspects of nutrition support therapy, particularly in terminal or end-of-life situations. Over the past 10 years, the American Society for Parenteral and Enteral Nutrition and others have responded to […]
Increased risk of melanoma in patients with chronic lymphocytic leukaemia
Increased risk of melanoma in patients with chronic lymphocytic leukaemia: systematic review and meta-analysis of cohort studies: An increased risk of melanoma has been variously reported in patients with chronic lymphocytic leukaemia (CLL), analogous with other immunosuppressed populations. To fully assess this association, we performed a systematic review and meta-analysis of available evidence from observational cohort studies. All such longitudinal studies of patients diagnosed with CLL that enabled quantitative assessment of the risk of melanoma compared with the general popul...περισσότερα »
Ipilimumab in anti-PD1 refractory metastatic melanoma
Ipilimumab in anti-PD1 refractory metastatic melanoma: a report of eight cases: Targeted therapy and immunotherapy in metastatic melanoma have led to a marked improvement in patients’ survival and their quality of life. Although there are data on anti-programmed-death-receptor-1 (anti-PD1) after ipilimumab, only few data are available on ipilimumab following anti-PD1 as the first-line treatment. The aim of our study was to evaluate tolerance and survival of patients treated with ipilimumab as the second-line immunotherapy among metastatic melanoma patients following anti-PD1 treatme...περισσότερα »
Periodic acid–Schiff-positive loops and networks as a prognostic factor in oral mucosal melanoma
Periodic acid–Schiff-positive loops and networks as a prognostic factor in oral mucosal melanoma: Abstract The prognostic factors of oral mucosal melanoma (OMM), a rare and aggressive neoplasm, remain to be determined. The aim of this study is to investigate the prognostic significance of vasculogenic mimicry in OMM. The clinical data of 62 patients with primary OMM treated in Shanghai Ninth People’s Hospital from April 2007 to April 2012 were retrieved and analyzed retrospectively. Staining of periodic acid–Schiff (PAS) and CD31 immunohistochemistry were performed to evaluate th... περισσότερα »
Prognostic markers and tumour growth kinetics in melanoma patients progressing on vemurafenib
Prognostic markers and tumour growth kinetics in melanoma patients progressing on vemurafenib: The BRAF inhibitor vemurafenib is an effective drug in patients with BRAF mutant metastatic melanoma, but resistance occurs after a median of 6 months. The anti-CTLA4-antibody, ipilimumab, is a standard first-line and second-line treatment option in Europe, with a median time to response of 2–3 months, but some patients show rapid clinical deterioration before that. The aim of this analysis was to identify prognostic markers for survival after failure of vemurafenib treatment to identify p... περισσότερα »
Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanoma
Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanoma: T-cell-mediated immunity has the ability to produce durable antimelanoma responses, resulting in improved survival of patients with advanced melanoma. Antigen presentation is a key determinant of T-cell responses. Gamma-interferon-inducible lysosomal thiol reductase (GILT) is critical for MHC class II-restricted presentation of multiple melanoma antigens to CD4+ T cells. However, GILT expression in melanoma has not been defined. We evaluated GILT and MHC class II expression in human primary and m...περισσότερα »
Seasonal variation in cutaneous melanoma incidence, link with recent UV levels: a population-based study in Belgium (2006–2011)
Seasonal variation in cutaneous melanoma incidence, link with recent UV levels: a population-based study in Belgium (2006–2011): Our objective was to test the hypothesis of a short-term late-promoting effect of ultraviolet (UV) exposure on the development of cutaneous melanoma as an explanation for the summer peak in melanoma incidence. Therefore, we studied seasonal variation in melanoma incidence in relation to recent UV levels by direct UV measurements. Data from the Belgian Cancer Registry on invasive cutaneous melanoma diagnosed during 2006–2011 were used for analysis. Daily d...περισσότερα »
AHNAK is downregulated in melanoma, predicts poor outcome, and may be required for the expression of functional cadherin-1
AHNAK is downregulated in melanoma, predicts poor outcome, and may be required for the expression of functional cadherin-1: The aim of this study was to further our understanding of the transformation process by identifying differentially expressed proteins in melanocytes compared with melanoma cell lines. Tandem mass spectrometry incorporating iTRAQ reagents was used as a screen to identify and comparatively quantify the expression of proteins in membrane-enriched samples isolated from primary human melanocytes or three melanoma cells lines. Real-time PCR was used to validate sign... περισσότερα »
4-Nitroquinoline-1-oxide-induced mutagen sensitivity and risk of cutaneous melanoma: a case–control analysis
4-Nitroquinoline-1-oxide-induced mutagen sensitivity and risk of cutaneous melanoma: a case–control analysis: Mutagen sensitivity assay, which measures the enhanced cellular response to DNA damage induced in vitro by mutagens/carcinogens, has been used in the study of cancer susceptibility. 4-Nitroquinoline-1-oxide (4-NQO), an ultraviolet (UV) radiation-mimetic chemical, can produce chromosomal breaks in mammalian cells and induce cancer. Given the potential role of 4-NQO as the experimental mutagen substituting for UV as the etiological carcinogen of cutaneous melanoma (CM), we te... περισσότερα »
Genomic profiling of invasive melanoma cell lines by array comparative genomic hybridization
Genomic profiling of invasive melanoma cell lines by array comparative genomic hybridization: [image: image]Malignant melanoma is one of the most aggressive human cancers. Invasion of cells is the first step in metastasis, resulting in cell migration through tissue compartments. We aimed to evaluate genomic alterations specifically associated with the invasive characteristics of melanoma cells. Matrigel invasion assays were used to determine the invasive properties of cell lines that originated from primary melanomas. Array comparative genomic hybridization analyses were carried out... περισσότερα »
Pazopanib in patients with soft tissue sarcoma
A randomized, double-blind, placebo-controlled, Phase III study of pazopanib in patients with soft tissue sarcoma: results from the Japanese subgroup: Objective This analysis of the Japanese subpopulation of the PALETTE Phase III, randomized, placebo-controlled study investigated efficacy and safety of pazopanib in patients with metastatic soft tissue sarcoma after failure of standard chemotherapy. Methods Patients were randomly assigned in a 2:1 ratio to receive either pazopanib 800 mg once daily or placebo, with no subsequent cross-over. Primary endpoint was progression-free sur... περισσότερα »
Long-term survival of nasopharyngeal carcinoma patients with Stage II in intensity-modulated radiation therapy era
Long-term survival of nasopharyngeal carcinoma patients with Stage II in intensity-modulated radiation therapy era: Objectives To evaluate the long-term survival and the role of chemotherapy in nasopharyngeal carcinoma (NPC) patients in Stage II treated by intensity-modulated radiation therapy (IMRT). Methods Three hundred and eleven NPC patients in Stage II were reviewed. All were treated with IMRT with or without chemotherapy, with 191, 20 and 100 patients being defined as T1N1M0, T2N0M0 and T2N1M0 stage, respectively. Results At a median follow-up of 57 months, the 5-year overa...περισσότερα »
Nivolumab-induced organizing pneumonia in a melanoma patient
Nivolumab-induced organizing pneumonia in a melanoma patient: We report the case of a 70-year-old woman with vaginal melanoma and multiple metastases in the lung. After the third dose of nivolumab, decreased room-air resting arterial oxygen saturation with bilateral basal fine crackles on auscultation developed despite the absence of respiratory symptoms. Computed tomography showed ground-glass opacities with airspace consolidations scattered with a peculiar distribution, and most were observed around the existing metastatic tumors in the lung. From the 42nd day to the 56th day aft...περισσότερα »
Trousseau's syndrome: cancer-associated thrombosis
Trousseau's syndrome: cancer-associated thrombosis: Trousseau's syndrome (cancer-associated thrombosis) is the second leading cause of death in cancer patients, after death from cancer itself. The risk of a venous thromboembolism is 4- to 7-fold higher in patients with cancer than in those without cancer. The causes of this impaired coagulation are associated with general patient-related risk factors, and other factors that are specific to the particular cancer or treatment. It is important to assess the risk of thrombotic events in cancer patients and administer effective prophyla... περισσότερα »
The Cancer-chemotherapy Concerns Rating Scale
The validity and reliability of the Korean version of the Cancer-chemotherapy Concerns Rating Scale: Objective The Cancer-chemotherapy Concerns Rating Scale was developed in Japan for outpatients undergoing chemotherapy, and its validity and reliability have been reported. The purpose of the study was to test the reliability and validity of the Korean version of the Cancer-chemotherapy Concerns Rating Scale. Methods The questionnaire was filled out by 199 cancer patients, who were currently undergoing outpatient chemotherapy. The data were analyzed using exploratory factor analysi... περισσότερα »
Quantification of the increase in thyroid cancer prevalence in Fukushima
Quantification of the increase in thyroid cancer prevalence in Fukushima after the nuclear disaster in 2011--a potential overdiagnosis?: A thyroid ultrasound examination programme has been conducted in Fukushima Prefecture, Japan, after the nuclear disaster in 2011. Although remarkably high prevalence of thyroid cancer was observed, no relevant quantitative evaluation was conducted. We calculated the observed/expected (O/E) ratio of thyroid cancer prevalence for the residents aged ≤20 years. Observed prevalence was the number of thyroid cancer cases detected by the programme throug...περισσότερα »
Understanding TERT Promoter Mutations
Understanding TERT Promoter Mutations: Telomerase (TERT) activation is fundamental step in tumorigenesis. By maintaining telomere length, telomerase relieves a main barrier on cellular lifespan, enabling limitless proliferation driven by oncogenes. The recently discovered, highly recurrent mutations in the promoter of TERT are found in over 50 cancer types, and are the most common mutation in many cancers. Transcriptional activation of TERT, via promoter mutation or other mechanisms, is the rate-limiting step in production of active telomerase. While TERT is expressed in stem cells...περισσότερα »
miRNA Profiles of Barrett's Esophagus and Esophageal Adenocarcinoma
miRNA Profiles of Barrett's Esophagus and Esophageal Adenocarcinoma: *Background:* The tissue specificity and robustness of miRNAs may aid risk prediction in individuals diagnosed with Barrett's esophagus. As an initial step, we assessed whether miRNAs can positively distinguish esophageal adenocarcinoma from the precursor metaplasia Barrett's esophagus. *Methods:* In a case–control study of 150 esophageal adenocarcinomas frequency matched to 148 Barrett's esophagus cases, we quantitated expression of 800 human miRNAs in formalin-fixed paraffin-embedded tissue RNA using NanoString ... περισσότερα »
E-Cigarette Marketing Online
E-Cigarette Marketing Online: A Systematic Content Analysis of Manufacturers and Retailers: Purpose: To identify the current atmosphere of online sales of Electronic Nicotine Delivery Systems (ENDS) in regards to key health-related and legal claims being made and to analyze the legal framework for regulating such claims. Methods: In December 2014, a systematic search protocol was employed with 3 popular search engines using six terms: 1) e-cigarettes, 2) e-cigs, 3) e-juice, 4) e-liquid, 5) e-hookah, and 6) vape pen. Websites from ENDS manufacturers and retailers were eligible for i...περισσότερα »
Cigarette Tax Revenues and Consumption
Cigarette Tax Revenues and Consumption under Current and Minimum-Price Regimes: Because nine out of ten lung cancer deaths are attributable to smoking, significant reductions in smoking are likely to reduce lung cancer death as well. It is well known that cigarette demand and consumption are negatively related to price, and that cigarette smokers use price minimization strategies to maintain their tobacco use patterns at a reasonably low cost when prices go up. Two consumer strategies that have received significant attention are legal tax avoidance and illegal tax evasion. These st... περισσότερα »
Completing Human Papillomavirus (HPV) Self-Testing at Home
Perspectives from Healthcare Providers and Women about Completing Human Papillomavirus (HPV) Self-Testing at Home: Purpose: Cervical cancer (CC) incidence and mortality rates are increased and CC screening rates are low among women living in Ohio Appalachia. Mailing human papillomavirus (HPV) self-tests to women to complete at home is a potential new strategy in the United States to engage women in the CC screening process. Our study sought to understand both providers' and women's perspectives on an HPV self-test that could be mailed to women and how those viewpoints may differ an... περισσότερα »
Oncology patient navigation (PN) programs : Patient Navigation Associated with Decreased 30-Day All-Cause Readmission
Patient Navigation Associated with Decreased 30-Day All-Cause Readmission: Background: Oncology patient navigation (PN) programs have been developed to improve outcomes and reduce disparities. Limited data exist to describe the effect of PN on important clinical outcomes, such as readmission, post cancer diagnosis. Methods: We conducted a retrospective cohort study of adults (≥18 yrs) diagnosed with first primary cancer from Jan 2013-Nov 2014 at a multi-site academic community based cancer institute. "Nearest-neighbor with caliper" propensity-score (PS) matching was used to match P...περισσότερα »
Association Between Post-Cancer Diagnosis Dietary Inflammatory Potential and Survival in WHI Observational Study and Dietary Modification Trial
Association Between Post-Cancer Diagnosis Dietary Inflammatory Potential and Survival in WHI Observational Study and Dietary Modification Trial: Background: Inflammation regulates key biologic processes in chronic disease and can be modulated by diet. Our objective was to use the dietary inflammatory index (DII), a novel tool to characterize the inflammatory potential of diet, to examine how post-cancer diagnosis dietary quality is associated with overall survival in the Women's Health Initiative (WHI) Observational Study (OS) and Dietary Modification Trial (DM). Methods: After exc...περισσότερα »
Cognitive Function in Adults: Folate and Inflammatory Markers Moderate the Association Between Helicobacter pylori Exposure
Folate and Inflammatory Markers Moderate the Association Between Helicobacter pylori Exposure and Cognitive Function in US Adults: Abstract Background *Helicobacter pylori* (*H. pylori*) infection is associated with cognitive deficits in humans, an association potentially mediated or moderated by folate concentration or inflammation. Materials and Methods We used the National Health and Nutrition Examination Survey (NHANES) datasets to examine whether folate concentration or inflammation mediates or moderates the relationship between *H. pylori* and cognitive function. Models were p...περισσότερα »
Salivary pellicles equalise surfaces’ charges and modulate the virulence of Candida albicans biofilm
Salivary pellicles equalise surfaces’ charges and modulate the virulence of Candida albicans biofilm via Oral Biology Publication date: June 2016 *Source:*Archives of Oral Biology, Volume 66 Author(s): Yuri Wanderley Cavalcanti, Melanie Wilson, Michael Lewis, David Williams, Plínio Mendes Senna, Altair Antoninha Del-Bel-Cury, Wander José da Silva Numerous environmental factors influence the pathogenesis of Candida biofilm and an understanding of these is necessary for appropriate clinical management. This study aimed to investigate the role of material type, pellicle and stage of biof...περισσότερα »
The Helicobacter heilmannii hofE and hofF Genes
The Helicobacter heilmannii hofE and hofF Genes are Essential for Colonization of the Gastric Mucosa and Play a Role in IL-1β-Induced Gastric MUC13 Expression: Abstract Background *Helicobacter heilmannii* is a zoonotic bacterium associated with gastric disease in humans. We recently showed that *H. heilmannii* binds to human gastric mucins and epithelial cells and highlighted a potential role for the murine Muc13 mucin in gastric *Helicobacter* colonization. The aims of this study were to investigate the role of the *H. heilmannii hof* gene locus encoding HofH/F/E/G/C/D in adhesio...περισσότερα »
Periodontitis : Favourable effects of Bacillus subtilis and Bacillus licheniformis
on experimental periodontitis in rats via Oral Biology Publication date: June 2016 *Source:*Archives of Oral Biology, Volume 66 Author(s): Michel R. Messora, Luciano J. Pereira, Renata Foureaux, Luiz F.F. Oliveira, Caio G. Sordi, Ana J.N. Alves, Marcelo H. Napimoga, Maria J.H. Nagata, Edilson Ervolino, Flávia A.C. Furlaneto ObjectivesThe purposes of this study were to evaluate, in rats: i) the effects of Bacillus species on the development of experimental periodontitis (EP) via microtomographic, immunological and hematological assays (Experiment 1—E1); ii) the effects of Bacillus spec...περισσότερα »
Intraoperative hypotension associated with massive deep space neck abscesses
in a 9-month old: A case report via International Journal of Pediatric Otorhinolaryngology Publication date: April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): Ann Plum, Lindsay Sobin, Sherard Tatum The neck is divided into multiple compartments by cervical fasciae. The deep space compartments, which all have a potential for becoming infected, are interconnected, providing a mechanism for the spread of infections. Thus, infections of the deep spaces can lead to devastating consequences, especially when there is extension to the mediastinum....περισσότερα »
Vocal fold movement impairment and feeding after neonatal cardiac surgery
Long-term follow-up of via International Journal of Pediatric Otorhinolaryngology Publication date: April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): Amy Li Richter, Julina Ongkasuwan, Elena C. Ocampo ObjectiveTo determine the long-term prognosis of children with vocal fold mobility impairment (VFMI) after cardiac surgery, with respect to time to normal feeding and incidence of admissions for pneumonia and feeding difficulties.MethodsA retrospective chart review was conducted of all neonates who had otolaryngology exam after cardiac surger... περισσότερα »
Neurocognitive outcomes after pediatric adenotonsillectomy for obstructive sleep apnea
: A systematic review and meta-analysis via International Journal of Pediatric Otorhinolaryngology Publication date: April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): Sungjin A. Song, Anthony M. Tolisano, Benjamin B. Cable, Macario Camacho ObjectiveTo provide an up-to-date systematic review and critical appraisal of prospectively performed studies evaluating neurocognitive function in children treated with adenotonsillectomy.Data sourcesPubMed/MEDLINE, Scopus, Web of Science, and the Cochrane Library.Review methodsSearches were performed f... περισσότερα »
An Unusual Laryngeal Mass
An Unusual Laryngeal Mass: A man presented with positional shortness of breath and sensation of airway obstruction; flexible fiber-optic laryngoscopy revealed a large, irregular pedunculated mass on the left anterior false vocal that was was seen to ball-valve in and out of the glottis with respiration. What is your diagnosis? [image: First page PDF preview]
Supraglottic Mass
Supraglottic Mass: A man in his 50s had a globus sensation in the throat and a 6-month history of throat pain; a CT scan of the neck revealed a submucosal hypodense supraglottic mass on the right side that was compressing the airway, and S100 protein immunostaining was positive. What is your diagnosis? [image: First page PDF preview]
Morbidity and Mortality Associated With Robotic Head and Neck Surgery
Morbidity and Mortality Associated With Robotic Head and Neck Surgery: This review of data from the Food and Drug Administration Manufacturer and User Facility Device Experience Database investigates the rates of morbidity and mortality associated with robotic head and neck surgery since 2009. [image: First page PDF preview]
Upper Airway Endoscopy to Evaluate Pediatric Pulmonary Aspiration.In children with chronic aspiration who warrant further evaluation, flexible laryngoscopy alone is not sufficient. There is a high incidence of aspiration-related airway lesions identified on DLB and not seen on flexible laryngoscopy, with 66.3% (110 of 166) of those lesions eventually requiring surgical intervention. Patients 1 year or older with a history of recurrent pneumonia or intubation are more likely to have an aspiration-related airway lesion.
Upper Airway Endoscopy to Evaluate Pediatric Pulmonary Aspiration: This medical record review of children who experienced pulmonary aspiration at a tertiary referral children’s hospital assesses the ability of direct laryngoscopy and bronchoscopy under general anesthesia to detect aspiration-related airway lesions and identifies clinical characteristics associated with airway lesions. *Importance* There is no consensus on the evaluation of pediatric patients with aspiration. *Objectives* To determine the yield of direct laryngoscopy and bronchoscopy (DLB) using general anesthes... περισσότερα »
Salivary Duct Carcinoma is an aggressive disease. A large number of cases in this review were carcinoma ex pleomorphic adenoma and had classic negative prognostic indicators, such as perineural invasion, vascular invasion, and extracapsular spread.ERBB2 positivity was not associated with any difference in survival. Facial nerve involvement appears to indicate worse prognosis, as does nodal stage higher than N1. Recurrence and metastasis after 5 years are rare.
A 20-Year Review of 75 Cases of Salivary Duct Carcinoma: This retrospective cohort study reviews a single institution’s experience with salivary duct carcinoma over a 20-year period, focusing on demographics, presentation, treatment, and outcome. *Importance* Salivary duct carcinoma is a rare, aggressive malignancy of the salivary glands. Owing to its rare nature, clinical data are limited, and only a few clinical studies comprise more than 50 patients. *Objective* To review the University of Pittsburgh Medical Center’s experience with salivary duct carcinoma over a 20-year peri... περισσότερα »
Association of Caffeine and Hearing Recovery
Association of Caffeine and Hearing Recovery: This laboratory study assesses whether daily caffeine intake impairs hearing recovery in a guinea pig model of exposure to acoustic overstimulation events. *Importance* Noise-induced hearing loss is an increasingly worrisome problem. Although caffeine intake is common in people involved in noise-related environments, the effect of caffeine on the recovery of hearing after a temporary threshold shift requires further understanding. *Objectives* To determine whether caffeine impairs hearing recovery in a guinea pig model exposed to aco... περισσότερα »
Earplugs to Prevent Hearing Loss From Recreational Noise Exposure
Earplugs to Prevent Hearing Loss From Recreational Noise Exposure: This systematic review assesses the effect of earplugs at preventing hearing loss from exposure to recreational noise such as concerts. *Importance* The prevalence of hearing loss among children and adolescents is rising dramatically, caused mainly by increased exposure to recreational noise. *Objective* To present a systematic overview of the effectiveness of wearing earplugs to music venues, such as nightclubs and concert halls, to prevent hearing loss and tinnitus directly after exposure. *Evidence Acquisitio...περισσότερα »
Electroacupuncture for Tinnitus: A Systematic Review
Electroacupuncture for Tinnitus: A Systematic Review: by Miao He, Xinrong Li, Yang Liu, Juan Zhong, Luyun Jiang, Ying Liu, Qing Chen, Yan Xie, Qinxiu Zhang Background Treatment effects of electroacupuncture for patients with subjective tinnitus has yet to be clarified. Objectives To assess the effect of electroacupuncutre for alleviating the symptoms of subjective tinnitus. Methods Extensive literature searches were carried out in three English and four Chinese databases (PubMed, EMBASE, Cochrane Library, CNKI, Wanfang Chinese Digital Periodical and Conference Database, VIP,...περισσότερα »
Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis
Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis: [image: access_free.gif] Thyroid , Vol. 0, No. 0. Author information Spyridoula Maraka,1,2 Naykky M. Singh Ospina,1,2 Derek T. O'Keeffe,1 Ana E. Espinosa De Ycaza,1Michael R. Gionfriddo,2,3 Patricia J. Erwin,4 Charles C. Coddington III,5 Marius N. Stan,1 M. Hassan Murad,2,6 and Victor M. Montori 1,2 1Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota. 2Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, Minnesota. 3Mayo Graduate School, Mayo C... περισσότερα »
High-Frequency Ultrasound-Guided Injection for the Generation of a Novel Orthotopic Mouse Model of Human Thyroid Carcinoma
High-Frequency Ultrasound-Guided Injection for the Generation of a Novel Orthotopic Mouse Model of Human Thyroid Carcinoma: [image: access_free.gif] Thyroid , Vol. 0, No. 0. Author information Adelaide Greco,1,2,3 Sandra Albanese,1,2 Luigi Auletta,4 Peppino Mirabelli,4 Antonella Zannetti,3Crescenzo D'Alterio,5 Gennaro Di Maro,4 Francesca Maria Orlandella,4 Giuliana Salvatore,2,4,6 Andrea Soricelli,4,6 and Marco Salvatore4 1Department of Advanced Biomedical Science, University of Naples Federico II, Naples, Italy. 2CEINGE Biotecnologie Avanzate, Naples, Italy. 3Institute of Biost... περισσότερα »
Intra-operative radiation therapy (IORT) in recurrent head and neck cancer
High-dose-rate intraoperative irradiation: current status and future directions *KS Hu, WE Enker, LB Harrison - Seminars in radiation oncology, 2002 - Elsevier* *... Intraoperative electron beam radiotherapy in the treatment of unresectable rectal cancer. ... advancedrectal cancer with external beam radiation, surgical resection, and intraoperative radiation therapy. ...Indications for and results of combined modality treatment of colorectal cancer. ...* *Γίνεται αναφορά σε 49 Σχετικά άρθρα Όλες οι 5 εκδοχές Παράθεση Αποθήκευση* *Intra*-*operative radiotherapy*–5 years of experienc... περισσότερα »
Palaeopathology: Current challenges and medical impact
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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The effect of exercise on vastus medialis oblique muscle architecture: An ultrasound investigation
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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Gastroesophageal junction carcinoma and brachial plexopathy: An anatomic explanation via perineural spread
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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Anatomy of superior medial genicular artery: A short cadaveric report
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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Long-term outcomes after adjuvant treatment of sequential versus combination docetaxel with doxorubicin and cyclophosphamide in node-positive breast cancer – BCIRG-005 randomized trial
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The concurrent TAC chemotherapy regime is not superior in long-term efficacy to the sequential AC->T regimen for adjuvant treatment of breast cancer but the regimens had different toxicity profiles. TAC was associated with increased febrile neutropenia and thrombocytopenia, while AC->T treated patients had more high grade myalgia, hand-foot syndrome, sensory neuropathy, and fluid retention. We […]
What is the clinical impact of the LUX-Lung 5 trial?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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Are strong opioids equally effective and safe in the treatment of chronic cancer pain? A multicenter randomized phase 4 ‘real life trial on the variability of response to opioids
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
This paper represents the results of the CERP study. The study compared efficacy and safety of four strong opioids in the treatment of cancer pain. In general the clinical experience indicates variable responses to opioids among patients. Instead in this study we observed a similar relief of pain but many changes in the therapeutic schedules […]
Single-Agent Capecitabine as Maintenance Therapy After Induction of XELOX (or FOLFOX) in First-Line Treatment of Metastatic Colorectal Cancer: Randomized clinical trial of efficacy and safety
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
In this multi-center, randomized phase III study, we tried to explore the value of maintenance therapy of capecitabine after induction of XELOX (or FOLFOX) in first-line treatment of metastatic colorectal cancer. Total 274 patients who achieved controlled disease (CR, PR or SD) after the first-line therapy of XELOX or FOLFOX were randomized 1:1 to receive […]
Pembrolizumab-induced necrotic myositis in a patient with metastatic melanoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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Risk factors, prevalence, and course of severe fatigue after breast cancer treatment: A meta-analysis involving 12,327 breast cancer survivors
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
This first meta-analysis on fatigue in breast cancer survivors showed that about one in four survivors suffers from severe fatigue. Risk factors of severe fatigue were higher disease stages, chemotherapy and a combination of surgery, radiotherapy and chemotherapy, both with and without hormone therapy. Having a partner, receiving only surgery, and surgery plus radiotherapy decreased […]
Which intravascular access method to choose during cardiopulmonary resuscitation?
Publication date: Available online 3 March 2016 Source:The American Journal of Emergency Medicine Author(s): Łukasz Szarpak, Zenon Truszewski, Jacek Smereka from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TcKC0N via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LD4vLV via IFTTT
Comparison of O2 and EtCO2 achieved by the polypropylene and conventional polyvinyl chloride face mask in healthy individuals
Publication date: Available online 3 March 2016 Source:The American Journal of Emergency Medicine Author(s): Takeshi Ueno, Nobuyasu Komasawa, Takanobu Fujisawa, Tomoki Yamasaki, Toshiaki Minami from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Qw7vq6 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VUgAwD via IFTTT
Knowledge, attitude and practices of paramedics regarding optic nerve sheath diameter ultrasonography
Publication date: Available online 3 March 2016 Source:The American Journal of Emergency Medicine Author(s): Łukasz Szarpak, Zenon Truszewski, Andrzej Kurowski, Silvia Samarin, Togay Evrin, Piotr Adamczyk, Łukasz Czyzewski from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Qw7v9L via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LD4vLJ via IFTTT
Intra-operative radiation therapy (IORT) in recurrent head and neck cancer
Intraoperative radiotherapy (IORT) an innovative technique that assures the delivery of radiation immediately after surgical resection and thus directly on tumor bed, without the necessity of excessive radiation protection measures. The clinical data regarding the use of IORT in head and neck cancer are little and a comprehensive and evidence-based analysis of recurrent head and… Continue reading Intra-operative radiation therapy (IORT) in recurrent head and neck cancer
Platysma flap using dual skin paddles
Publication date: Available online 2 March 2016 Source:British Journal of Oral and Maxillofacial Surgery Author(s): El Muiz A. Mustafa, Sunil K. Bhatia, Doug E. Hammond The platysma myocutaneous flap is rarely reported as an option for reconstruction in the head and neck. In our experience it is a reliable flap that is easy to raise,… Continue reading Platysma flap using dual skin paddles
Correlation between hyoid bone position and airway dimensions in Chinese adolescents by cone beam computed tomography analysis
This study aimed to investigate the correlation between upper airway dimensions and hyoid bone position in Chinese adolescents based on cone beam computed tomography (CBCT) images. CBCT images from a total of 254 study subjects were included. The upper airway and hyoid bone parameters were measured by Materialism’s interactive medical image control system (MIMICS) v.16.01… Continue reading Correlation between hyoid bone position and airway dimensions in Chinese adolescents by cone beam computed tomography analysis
Case Report Acute myelitis due to Zika virus infection
In January, 2016, a 15-year-old girl with a history only of an ovarian cyst was admitted to hospital in Pointe-à-Pitre, Guadeloupe, with left hemiparesis. 7 days previously she had presented to the emergency department with left arm pain, frontal headaches, and conjunctival hyperaemia, but no fever, signs of meningeal irritation, or sensory or motor deficits.… Continue reading Case Report Acute myelitis due to Zika virus infection
