Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
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Δευτέρα 11 Απριλίου 2016

OtoRhinoLaryngology & Medicine,New Articles,April 12th,2016


PBP4 mediates high-level resistance to new generation cephalosporins in Staphylococcus aureus

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
[PublishAheadOfPrint]: *Staphylococcus aureus* is an important cause of both hospital and community-associated MRSA infections worldwide. β-lactam antibiotics are drugs of choice to treat *S. aureus* infections, but resistance to these and other antibiotics make treatment problematic. High-level β-lactam resistance of *S. aureus* has always been attributed to the horizontally acquired penicillin binding protein 2a (PBP2a) encoded by the *mecA* gene. Here we show that *S. aureus* can also express high-level resistance to β-lactams, including new generation broad-spectrum cephalospor... περισσότερα »

Lantibiotic Treatment of Staphylococcus aureus-induced Skin Infections

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Monitored by in vivo Bioluminescent Imaging [PublishAheadOfPrint]: *Staphylococcus aureus* is a bacterial pathogen responsible for the majority of skin and soft tissue infections. Antibiotics are losing their efficacy as treatment for skin and soft tissue infections as a result of increased resistance in a variety of pathogens, including *S. aureus*. It is thus imperative to explore alternative antimicrobial treatments to ensure future treatment options for skin and soft tissue infections. A select few lantibiotics, a group of natural defence peptides produced by bacteria, inhibit ... περισσότερα »

Efflux mediated macrolide resistance due to mef(E) and mel carried by the mega element is common in Streptococcus pneumoniae

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
ICESpy009, a conjugative genetic element carrying mef(E) in Streptococcus pyogenes [PublishAheadOfPrint]: Efflux mediated macrolide resistance due to *mef*(E) and *mel* carried by the mega element is common in *Streptococcus pneumoniae* where it was originally characterized, but it is rare in *Streptococcus pyogenes.* In *S. pyogenes* mega has been previously found enclosed in Tn*2009*, a composite genetic element of the Tn*916* family containing *tet*(M) and conferring erythromycin and tetracycline resistance. In this study, *S. pyogenes* isolates containing *mef*(E), apparently n... περισσότερα »

Investigation of depression and quality of life in nurses working in hospitals

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Investigation of depression and quality of life in nurses working in hospitals: 2016-04-11T22-25-23Z *Source:* TAF Preventive Medicine Bulletin Merve Kızılırmak, Satı Demir. AIM: The aim of this study was to evaluate depression and quality of life in nurses working in hospital. METHODS: The study was conducted in three hospitals in Eskişehir city center. Participants of the study were 329 nurses working at different departments at hospitals. Data were collected through Nurse Information Form, Beck Depression Scale, and SF-36 Life Quality Scale. Kruskal Wallis test, Bonferroni Co... περισσότερα »

Evaluation of intraoperative nursing care by patient

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Evaluation of intraoperative nursing care by patient: 2016-04-11T22-25-23Z *Source:* TAF Preventive Medicine Bulletin Semra Eyi, Nevin Kanan, Neriman Akyolcu, Mehmet Levhi Akın, Rengin Acaroğlu. *Abstract* Aim: The purpose of this study was to evaluate intraoperative nursing care by patients and to determine the effects of patient factors in quality of care. Materials and methods: The Descriptive-Type Study was carried out with a total of 530 patients who underwent operation in The Kasımpaşa Military Hospital between June and December. The data was collected by using “Good Perio... περισσότερα »

Spontaneous subcutaneous tissue haematoma associated with warfarin

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Spontaneous subcutaneous tissue haematoma associated with warfarin: Description A 75-year-old man with a history of non-valvular atrial fibrillation anticoagulated on warfarin for the past 5 years without any prior complications presented to the emergency department with a cutaneous haemorrhagic lesion on his right lower limb, developed within the previous 24 h. There was no history of local skin lesion or trauma, and no infection or erroneous warfarin overdose. Physical examination highlighted voluminous haematic phlyctena in the anterior, lateral surface of the right leg, surroun... περισσότερα »

Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak

The Journal of Physiology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RQtlsy via IFTTT

Cross‐reactivity of hepatitis C virus specific vaccine‐induced T cells at immunodominant epitopes

European Journal of Immunology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1S6ylIl via IFTTT

Acute ischemic stroke (AIS) in the pediatric population

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
Basilar artery occlusion in a child treated successfully with mechanical thrombectomy using ADAPT: Acute ischemic stroke (AIS) in the pediatric population is rare. Furthermore, it is common for physicians to take significantly longer diagnosing a posterior circulation stroke in a child than in an adult. There are increasing case reports in the literature of treating AIS in children with intravenous tissue plasminogen activator, intra-arterial thrombolysis, and/or mechanical thrombectomy. We present the first case of pediatric AIS treated using a direct aspiration first pass techniq... περισσότερα »

Oesophageal rupture masquerading as ST elevation myocardial infarction (STEMI)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Oesophageal rupture masquerading as STEMI: A 67-year-old man presented to the emergency department, with acute onset of chest pain. Based on ECG changes suggestive of ST elevation myocardial infarction (STEMI), he was taken emergently to the cardiac catheterisation laboratory for coronary angiography. There he was found to have only non-obstructive coronary disease. Subsequent physical examination and review of his chest radiograph revealed subcutaneous emphysema, and CT scan revealed a distal oesophageal rupture and pneumomediastinum. After stabilisation in the intensive care unit... περισσότερα »

Surgical management of macroglossia secondary to amyloidosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Surgical management of macroglossia secondary to amyloidosis: The authors report a case of amyloidosis-induced macroglossia treated with surgical reduction of the tongue using a keyhole to inverted T method with particular emphasis on the postoperative sequelae. Significant tongue swelling persisted for longer than anticipated requiring tracheostomy to remain in situ for 14 days.

Third nerve palsy in a patient with scleroderma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Unmasking the elusive giant: an unusual case presenting as third nerve palsy in a patient with scleroderma: We report a case of an 80-year-old woman being treated with rituximab and maintenance corticosteroids for long-standing scleroderma who presented with right-sided third nerve palsy. Radiological investigations including CT, MRI and MR angiography of the brain were unremarkable. The patient was discharged with a diagnosis of probable microvascular third nerve palsy but was readmitted 1 week later with total visual loss in her left eye. Despite the absence of diagnostic clinica... περισσότερα »

Recurrent or Metastatic Human Papilloma Virus-positive Head and Neck Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Clinical Outcomes in Patients with Background: There are few data regarding the role of human papilloma virus (HPV) in recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). Patients and Methods: A retrospective chart review was carried out using our electronic medical record (EPIC) for all patients diagnosed with HPV-positive R/M HNSCC between 2010 and 2014 with minimum of 6 months of follow-up in order to assess progression-free survival (PFS) and overall survival (OS). Results: We assessed 11 patients who underwent a variety of treatments. PFS and OS were 7 ...περισσότερα »

Risk of Metabolic Complications in Patients with Solid Tumors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Treated with mTOR inhibitors: Meta-analysis: Background/Aim: Numerous trials have described a wide variation of metabolic complications associated with the mammalian target of rapamycin inhibitors (mTORi). This analysis aimed to report and critically analyze the risks of mTORi-associated metabolic complications. Materials and Methods: A comprehensive search of all published phase II or III randomized controlled trials were investigated. Outcomes included were adverse effect profiles of hyperglycemia (HGC), hypertriglyceridemia (HTG), and hypercholesterolemia (HCE). Results: Sixtee... περισσότερα »

Radiotherapy in Soft-tissue Sarcoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Older Age Modifies Oncologic Outcome Following Radiotherapy in Soft-tissue Sarcoma: A Subtype-specific SEER Analysis: Background: Given the immune-mediated mechanisms of radiotherapy (RT), we hypothesized that age would affect response to RT in patients with soft-tissue sarcoma (STS) undergoing surgery. Materials and Methods: Using the Surveillance, Epidemiology, and End Results Program (1990-2011), we identified 15,380 patients with non-metastatic STS. Stratified by age (≥65 years) and histological subtype, we assessed predictors of overall (OS) and disease-specific survival (DSS)... περισσότερα »

Radiotherapy Alone for Malignant Spinal Cord Compression

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
in Young Men with Seminoma: Aim: Seminomas are very radiosensitive tumors. Therefore, patients with malignant spinal cord compression (MSCC) from seminoma may not require for neurosurgery in addition to radiotherapy. In this study, radiotherapy alone was evaluated in young men with MSCC from seminoma. Patients and Methods: Four young men with MSCC due to vertebral lesions from metastatic seminoma received radiotherapy alone. The impact of radiotherapy on motor function and gait function, local control of MSCC and survival were retrospectively evaluated. Results: All patients showe...περισσότερα »

Chemotherapy induces mutagenicity and cytotoxicity in buccal mucosa cells

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Cytogenetic Biomonitoring in Buccal Mucosa Cells from Women Submitted to Chemotherapy After Mastectomy for Breast Cancer: In addition to surgery, one of the most widely applied treatments for breast cancer is chemotherapy. Chemotherapy is currently considered efficient in curing this disease; however, the therapy may induce damage to the patient's genetic material. Thus, the aim of this study was to evaluate putative cytotoxic and mutagenic effects induced by chemotherapy in women diagnosed with breast cancer. For this purpose, a cross-sectional study was carried out in 42 women, a...περισσότερα »

Cytogenetic Biomonitoring in Buccal Mucosa Cells

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
from Women Submitted to Chemotherapy After Mastectomy for Breast Cancer: In addition to surgery, one of the most widely applied treatments for breast cancer is chemotherapy. Chemotherapy is currently considered efficient in curing this disease; however, the therapy may induce damage to the patient's genetic material. Thus, the aim of this study was to evaluate putative cytotoxic and mutagenic effects induced by chemotherapy in women diagnosed with breast cancer. For this purpose, a cross-sectional study was carried out in 42 women, aged 18 to 70 years, allocated according to the d...περισσότερα »

Hydration with 15 mEq Magnesium Is Effective at Reducingthe Risk for Cisplatin-induced Nephrotoxicity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
in Patients Receiving Cisplatin (>=50 mg/m2) Combination Chemotherapy: Aim: We aimed to assess whether the efficacy of pre-hydration with 15 mEq magnesium prevents cisplatin-induced nephrotoxicity in cisplatin regimens (dosage: 50 mg/m2 or more) for gynecological cancer. Patients and Methods: This historical, prospective cohort study compared nephrotoxicity in patients who received pre-hydration with or without magnesium sulfate (Mg-hydration group, n=37; non-Mg-hydration group, n=37). We used serum creatinine (Scr), creatinine clearance (Ccr) and Risk, Injury, Failure, Loss of ki...περισσότερα »

Early Response of Esophageal Cancer to Neoadjuvant Chemotherapy with Docetaxel-Cisplatin-5-Fluorouracil Represents Sensitivity: A Phase II Study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Early Response of Esophageal Cancer to Neoadjuvant Chemotherapy with Docetaxel-Cisplatin-5-Fluorouracil Represents Sensitivity: A Phase II Study: Aim: The aim of this study was to assess the response rate and find improvements. Patients and Methods: Fifty-five patients with esophageal cancer were enrolled. Neoadjuvant chemotherapy (one or two courses) consisted of 60 mg/m2 docetaxel on day 1, 70 mg/m2 cisplatin on day 1 and continuous infusion of 5-fluorouracil at 600 mg/m2/day on day 1-5. All patients were examined for clinical response by computed tomography and endoscopy at eac...περισσότερα »

The Detection of Bone-metastatic Disease

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Testing of a Novel Cancer Metastatic Multiplex Panel for the Detection of Bone-metastatic Disease - a Pilot Study: Background: Bone metastases develop in several malignancies (multiple myeloma, breast, prostate and lung carcinoma) and cause several complications. The aim of this study was to search for new biomarkers to use in monitoring of bone metastatic disease with the use of xMAP technology. Patients and Methods: We assessed 62 oncological patients: 23 with no bone metastases, 28 with metastatic disease not having undergone therapy and 11 with metastatic disease treated by den... περισσότερα »

Epidural spinal cord compression (ESCC) from thyroid cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Outcomes After Irradiation of Epidural Spinal Cord Compression Due to Metastatic Thyroid Cancer: Aim: Epidural spinal cord compression (ESCC) from thyroid cancer is uncommon. This study aimed to contribute to the identification of the most appropriate treatment for these patients. Patients and Methods: Fourteen patients receiving irradiation alone were retrospectively evaluated. Results: Improvement of motor deficits occurred in 36% of patients, further progression was prevented in another 43% (overall response=79%). One of six non-ambulatory patients (17%) became ambulatory. The 1...περισσότερα »

Irradiation of Epidural Spinal Cord Compression Due to Metastatic Thyroid Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Outcomes After Aim: Epidural spinal cord compression (ESCC) from thyroid cancer is uncommon. This study aimed to contribute to the identification of the most appropriate treatment for these patients. Patients and Methods: Fourteen patients receiving irradiation alone were retrospectively evaluated. Results: Improvement of motor deficits occurred in 36% of patients, further progression was prevented in another 43% (overall response=79%). One of six non-ambulatory patients (17%) became ambulatory. The 12-month rate of freedom from in-field recurrence was 85%; long-course irradiatio... περισσότερα »

Carcinogenesis and Progression in Solid Tumours

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Review: the Contribution of both Nature and Nurture to AbstractCancer is a leading cause of mortality worldwide. Cancer arises due to a series of somatic mutations that accumulate within the nucleus of a cell which enable the cell to proliferate in an unregulated manner. These mutations arise as a result of both endogenous and exogenous factors. Genes that are commonly mutated in cancer cells are involved in cell cycle regulation, growth and proliferation. It is known that both nature and nurture play important roles in cancer development through complex gene-environment interactio... περισσότερα »

The Human Papillomavirus Vaccine

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Current Perspective and Future Role in Prevention and Treatment of Anal Intraepithelial Neoplasia and Anal Cancer: The incidences of human papillomavirus (HPV)-related anal cancer and its precursor lesion, anal intraepithelial neoplasia, are rising in the U.S. and globally. Five-year survival rates with current modalities of treatment for anal cancer are generally favorable for localized and regional disease. For metastatic disease, the relative survival rate is poor. Major contributing factors for the increase in anal cancer incidence include increasing receptive anal intercourse ... περισσότερα »

Electrocardiographic Characterization of Ramucirumab on the Corrected QT Interval

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
in a Phase II Study of Patients With Advanced Solid Tumors: Lessons Learned Cardiotoxicity can be a serious complication of anticancer therapies. To enable earlier identification of drug-related cardiac effects, the International Conference on Harmonization (ICH) adopted the ICH E14 Guidelines for evaluating the potential for QT/corrected QT (QTc) interval prolongation and proarrhythmic potential for nonantiarrhythmic drugs. The results of the evaluation of ramucirumab on the QT/QTc interval show a lack of effect on QTc prolongation in patients with advanced cancer. Background. Ra... περισσότερα »

Standard prophylaxis for chemotherapy-induced nausea and vomiting (CINV) with highly emetogenic and anthracycline-cyclophosphamide-based chemotherapy includes a 5-hydroxytryptamine-3 receptor antagonist, a neurokinin-1 receptor antagonist (NK1RA), and corticosteroid therapy.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Safety of an Oral Fixed Combination of Netupitant and Palonosetron (NEPA): Pooled Data From the Phase II/III Clinical Program: Background. Standard prophylaxis for chemotherapy-induced nausea and vomiting (CINV) with highly emetogenic and anthracycline-cyclophosphamide-based chemotherapy includes a 5-hydroxytryptamine-3 receptor antagonist, a neurokinin-1 receptor antagonist (NK1RA), and corticosteroid therapy. NEPA is a fixed combination of netupitant and palonosetron. The primary objective of this analysis was to document the safety profile, including cardiac safety, of NEPA + dex... περισσότερα »

Novel Treatments for Rare Cancers

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
The U.S. Orphan Drug Act Is Delivering--A Cross-Sectional Analysis: Background. Rare cancers are a heterogeneous group of conditions with highly unmet medical needs. Although infrequent in individuals, rare cancers affect millions of people who deserve effective treatments. Therefore, we systematically analyzed the impact of the U.S. Orphan Drug Act of 1983 on delivery of novel treatments for rare cancers. Methods. Quantitative cross-sectional analysis was conducted on the U.S. Food and Drug Administration Orphan Drug Product database according to Strengthening the Reporting of Ob...περισσότερα »

Individual skeletal metastasis management

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Galectin-3 in bone tumor microenvironment: a beacon for individual skeletal metastasis management: AbstractThe skeleton is frequently a secondary growth site of disseminated cancers, often leading to painful and devastating clinical outcomes. Metastatic cancer distorts bone marrow homeostasis through tumor-derived factors, which shapes different bone tumor microenvironments depending on the tumor cells’ origin. Here, we propose a novel insight on tumor-secreted Galectin-3 (Gal-3) that controls the induction of an inflammatory cascade, differentiation of osteoblasts, osteoclasts, an... περισσότερα »

Firefighter Recruit - Sun Lakes Fire District

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 20 δευτερόλεπτα
SUN LAKES FIRE DISTRICT 25025 S ALMA SCHOOL ROAD SUN LAKES, ARIZONA 85248 Updated: April 11, 2016 Job Classification: Firefighter Recruit The Sun Lakes Fire District is accepting applications for Firefighter recruit. The application period will begin April 11, 2016 and all testing through National Testing Network (NTN) must be completed by May 6, 2016 at 4:00 pm. Candidates do not need to fill out the ... from EMS via xlomafota13 on Inoreader http://ift.tt/1Q3BVi3 via IFTTT

Find Telrepco at booth #’s 20 & 21 at the CPCA 2016 Public Safety Expo on April 21

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 20 δευτερόλεπτα
We hope to see you next week at the Connecticut Police Chiefs Association 2016 Public Safety Expo on April 21st at The Aqua Turf in Plantsville, CT! We will be at Booths 20 & 21 displaying new and refurbished Panasonic Toughbooks and related accessories, the Panasonic Arbitrator in-car video and the newly introduced Panasonic Body Worn Camera, as well as new Getac ruggedized laptops and tablets ... from EMS via xlomafota13 on Inoreader http://ift.tt/1VjQVkj via IFTTT

Firefighter/EMS - Central Mason Fire and EMS

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 20 δευτερόλεπτα
CENTRAL MASON FIRE & EMS 122 WEST FRANKLIN STREET SHELTON, WASHINGTON 98584 http://www.cmfe.org Updated: April 07, 2016 Job Classification: Firefighter/EMT The Central Mason Fire & EMS is currently building an ongoing eligibility list for Firefighter/EMT. This position requires FireTEAM through National Testing Network (NTN) and a valid CPAT. Salary Information: Entry Firefighter/EMT $5069.00 ... from EMS via xlomafota13 on Inoreader http://ift.tt/1S1kJfn via IFTTT

Firefighter/EMT - Star Fire Protection District

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 20 δευτερόλεπτα
STAR FIRE PROTECTION DISTRICT 10831 WEST STATE STREET STAR, IDAHO 83669 Updated: April 08, 2016 Job Classification: Firefighter/EMT The Star Fire Protection District is currently building an eligibility list for Entry Level Firefighter/EMT. All testing through National Testing Network (NTN)must be completed by May 14, 2016 by 10PM. Salary Information: Recruit (First Year of employment) - $36,000.00 ... from EMS via xlomafota13 on Inoreader http://ift.tt/1StgmJj via IFTTT

Nuclear Cytological Changes in Normal Buccal Mucosa and Peritumoural Area in Patients with Oral Squamous Cell Carcinoma Receiving Concomitant Chemoradiotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Evaluation of Various Objectives. To evaluate the role of serial cytological assay in calculating the nuclear response of contralateral normal buccal mucosa and peritumoural area of squamous cell carcinoma of oral cavity in patients receiving fractionated radiotherapy (RT) and chemotherapy. Materials and Methods. This prospective, nonrandomized study was comprised of 76 histologically confirmed cases of oral squamous cell carcinoma on cyclical chemoradiation treatment. Chemoradiosensitivity was evaluated using serial scrape smears taken before and after immediate exposure to CCRT, ...περισσότερα »

Generating Mini-Organs in Culture

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Generating Mini-Organs in Culture: AbstractThe discovery of human-induced pluripotent stem cells (iPSCs) has provided new opportunities for studying human diseases and, ultimately, generating therapies. However, the practical application of iPSCs remains a challenge due to the failure of current two-dimensional culture methods targeted on generating single pure lineage cells. The developmental process of directed differentiation requires three-dimensional and temporal cellular interactions between multiple supporting cells and their environments. Recently, novel spatiotemporal stem... περισσότερα »

Solid Variant of Adenoid Cystic Carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Difficulties in Diagnostic Recognition: Adenoid cystic carcinoma (ACC) is a malignant neoplasm that mainly affects the salivary glands but has been described in many other anatomical sites. It is composed of basaloid cells with myoepithelial/basal cell differentiation and ductal epithelial cells that proliferate in a fibrous stroma, with variable amounts of myxohyaline material. Three patterns (cribriform, tubular, and solid) occur, and the solid variant is characterized by a predominant compact sheet-like and nested pattern of rounded basaloid cells lacking obvious cribriform or ... περισσότερα »

The Hereditary Periodic Fever Syndromes

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
A Comprehensive Overview of AbstractInnate immunity is a critical partner in the regulation of inflammation and some mutations in genes implied in innate immunity pathways can cause genetic disorders characterized by seemingly unprovoked self-limited inflammatory attacks. These rare conditions are collectively named “hereditary periodic fever syndromes” (HPFS), and protean pathogenetic mechanisms combined with several clinical phenotypes characterize at least four distinct conditions: (1) familial Mediterranean fever, which is the prototype and the most widely recognized among HPFS... περισσότερα »

The Microbiome in Barrett’s Esophagus and Esophageal Adenocarcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Potential Role of AbstractEsophageal adenocarcinoma and its precursor Barrett’s esophagus have been rapidly increasing in incidence for half a century, for reasons not adequately explained by currently identified risk factors such as gastroesophageal reflux disease and obesity. The upper gastrointestinal microbiome may represent another potential cofactor. The distal esophagus has a distinct microbiome of predominantly oral-derived flora, which is altered in Barrett’s esophagus and reflux esophagitis. Chronic low-grade inflammation or direct carcinogenesis from this altered microbi...περισσότερα »

Evaluation of IL-1β, IL-1ra, and IL-10 levels and outcome of periodontal therapy in chronic periodontitis with familial Mediterranean fever

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
Evaluation of IL-1β, IL-1ra, and IL-10 levels and outcome of periodontal therapy in chronic periodontitis with familial Mediterranean fever: Abstract ObjectivesThis study aimed to examine the IL-1β, IL-1ra, and IL-10 cytokine levels in gingival crevicular fluid (GCF) and serum of familial Mediterranean fever (FMF) and chronic periodontitis (CP) patients, and their response to nonsurgical periodontal therapy. Materials and methodsA total of 50 patients, 15 FMF patients with generalized chronic periodontitis (FMF-CP), 15 systemically healthy patients with generalized chronic perio... περισσότερα »

Streptococcus mutans (S. mutans) is the major aetiological agent of dental caries, and the transpeptidase Sortase A (SrtA) plays a major role in cariogenicity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
Effects of missense mutations in sortase A gene on enzyme activity in Streptococcus mutans: Abstract Background*Streptococcus mutans* (*S. mutans*) is the major aetiological agent of dental caries, and the transpeptidase Sortase A (SrtA) plays a major role in cariogenicity. The T168G and G470A missense mutations in the *srtA* gene may be linked to caries susceptibility, as demonstrated in our previous studies. This study aimed to investigate the effects of these missense mutations of the *srtA* gene on SrtA enzyme activity in *S. mutans* . MethodsThe point mutated recombinant *S... περισσότερα »

Audiovisual speech perception development at varying levels of perceptual processing

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
Audiovisual speech perception development at varying levels of perceptual processing: [image: cm_sbs_024_plain.png] This study used the auditory evaluation framework [Erber (1982). Auditory Training (Alexander Graham Bell Association, Washington, DC)] to characterize the influence of visual speech on audiovisual (AV) speech perception in adults and children at multiple levels of perceptual processing. Six- to eight-year-old children and adults completed auditory and AV speech perception tasks at three levels of perceptual processing (detection, discrimination, and recognition). Th... περισσότερα »

Binaural hearing in children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
using Gaussian enveloped and transposed tones: Children who use bilateral cochlear implants (BiCIs) show significantly poorer sound localization skills than their normal hearing (NH) peers. This difference has been attributed, in part, to the fact that cochlear implants(CIs) do not faithfully transmit interaural time differences(ITDs) and interaural level differences (ILDs), which are known to be important cues for sound localization. Interestingly, little is known about binaural sensitivity in NH children, in particular, with stimuli that constrain acoustic cues in a manner repre... περισσότερα »

Predictions of middle-ear and passive cochlear mechanics using a finite element model of the pediatric ear

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
Predictions of middle-ear and passive cochlear mechanics using a finite element model of the pediatric ear: [image: cm_sbs_024_plain.png] A finite element (FE)model was developed based on histological sections of a temporal bone of a 4-year-old child to simulate middle-ear and cochlear function in ears with normal hearing and otitis media. This pediatric model of the normal ear, consisting of an ear canal, middle ear, and spiral cochlea, was first validated with published energy absorbance (EA) measurements in young children with normal ears. The model was used to simulate EA in a... περισσότερα »

The role of continuous low-frequency harmonicity cues for interrupted speech perception in bimodal hearing

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
The role of continuous low-frequency harmonicity cues for interrupted speech perception in bimodal hearing: [image: cm_sbs_024_plain.png] Low-frequency acoustic cues have been shown to enhance speech perception by cochlear-implant users, particularly when target speech occurs in a competing background. The present study examined the extent to which a continuous representation of low-frequency harmonicity cues contributes to bimodal benefit in simulated bimodal listeners. Experiment 1 examined the benefit of restoring a continuous temporal envelope to the low-frequency ear while th... περισσότερα »

Assessing the validity of subjective reports in the auditory streaming paradigm

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
Assessing the validity of subjective reports in the auditory streaming paradigm: [image: cm_sbs_024_plain.png] While subjective reports provide a direct measure of perception, their validity is not self-evident. Here, the authors tested three possible biasing effects on perceptual reports in the auditory streaming paradigm: errors due to imperfect understanding of the instructions, voluntary perceptual biasing, and susceptibility to implicit expectations. (1) Analysis of the responses to catch trials separately promoting each of the possible percepts allowed the authors to exclude... περισσότερα »

Strength model of the matrix element in SiC/SiC composites

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 25 δευτερόλεπτα
Publication date: 5 July 2016 *Source:*Materials & Design, Volume 101 Author(s): Sheng Zhang, Xiguang Gao, Jing Chen, Hongnian Dong, Yingdong Song A strength model of the matrix element is developed for SiC/SiC composites to predict the matrix cracking process. A strength formula of the matrix element is presented. Modeling results using the previously introduced critical matrix strain energy criterion and the probabilistic-statistical approach are also examined. To verify these models, real-time matrix crack detection and a macroscopic tensile test are performed on SiC/SiC minicomp...περισσότερα »

Solution growth of peony-like copper hydroxyl-phosphate (Cu2(OH)PO4) flowers on Cu foil and their photocatalytic activity under visible light

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 25 δευτερόλεπτα
Publication date: 15 June 2016 *Source:*Materials & Design, Volume 100 Author(s): Siyuan Yang, Kejia Xu, Hongjuan Wang, Hao Yu, Shanqing Zhang, Feng Peng Novel self-assemble peony-like three-dimensional (3D) copper hydroxyl phosphate (Cu2(OH)PO4) was synthesized on the copper foil by a solution-growth method. The self-aggregate peony-like 3D Cu2(OH)PO4 flowers with the diameter size up to 10–20μm were composed of hundreds of anisotropic cross-linking petals with several hundred nanometers wide and 110–170nm thick. After the morphology and structure of these Cu2(OH)PO4 flowers were ... περισσότερα »

Density and glass forming ability in amorphous atomic alloys: The role of the particle softness

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 25 δευτερόλεπτα
A key property of glass forming alloys, the anomalously small volume difference with respect to the crystal, is shown to arise as a direct consequence of the soft repulsive potentials between metals. This feature of the inter-atomic potential is demonstrated to be responsible for a significant component of the glass forming ability of alloys due to the decrease in the enthalpy of fusion and the associated depression of the freezing point. from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1ROLXcw via IFTTT

Density functional study of the electronic structure of dye-functionalized fullerenes and their model donor-acceptor complexes containing P3HT

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 25 δευτερόλεπτα
We study the electronic structure of C60fullerenes functionalized with a thiophene-diketo-pyrrolopyrrole-thiophene based chromophore using density functional theory combined with large polarized basis sets. As the attached chromophore has electron donor character, the functionalization of the fullerene leads to a donor-acceptor (DA) system. We examine in detail the effect of the linker and the addition site on the electronic structure of the functionalized fullerenes. We further study the electronic structure of these DA complexes with a focus on the charge transfer excitations. ... περισσότερα »

[Cytogenetic and molecular characterization of a patient with partial 6q trisomy and 1q monosomy].

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 26 δευτερόλεπτα
*[Cytogenetic and molecular characterization of a patient with partial 6q trisomy and 1q monosomy].* Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016 Apr 10;33(2):231-234 Authors: Qin F, Lu X, Feng Y, Tang P, Niu G, Li F, Zhang J Abstract OBJECTIVE: To analyze a girl with moderate mental retardation and speech and language disorders with cytogenetics technique and next-generation sequencing(NGS). METHODS: G-banding chromosome analysis was used to ascertain the karyotype of the child and her parents, and NGS was used for determining the size and origin of the abnormal chromosome fragment.... περισσότερα »

Vibratory stimulus reduces in vitro biofilm formation on tracheoesophageal voice prostheses.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 26 δευτερόλεπτα
*Vibratory stimulus reduces in vitro biofilm formation on tracheoesophageal voice prostheses.* Laryngoscope. 2016 Apr 5; Authors: Wannemuehler TJ, Lobo BC, Johnson JD, Deig CR, Ting JY, Gregory RL Abstract OBJECTIVES/HYPOTHESIS: Demonstrate that biofilm formation will be reduced on tracheoesophageal prostheses when vibratory stimulus is applied, compared to controls receiving no vibratory stimulus, in a dynamic in vitro model of biofilm accumulation simulating the interface across the tracheoesophageal puncture site. STUDY DESIGN: Prospective, randomized, controlled, crossover in ... περισσότερα »

Parotid-gland Stem-cell Sparing Intensity-modulated Radiotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Parotid-gland Stem-cell Sparing Intensity-modulated Radiotherapy: *Condition*: Head and Neck Cancer *Intervention*: Radiation: Intensity-modulated Radiotherapy *Sponsor*: University Medical Center Groningen Rationale: Radiation-induced parotid gland dysfunction, often leading to xerostomia is the most-frequently occurring side-effect with a major impact on patient-reported quality of life after radiotherapy for head and neck cancer (HNC). Therefore, treatments for HNC are currently optimized to minimize the mean dose to the parotid glands. Though this resulted in a significa... περισσότερα »

Cabozantinib for the Treatment of Radioiodine (RAI)-Refractory Differentiated Thyroid Carcinoma (DTC) in the First-line Setting

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
A Phase II Trial of Cabozantinib for the Treatment of Radioiodine (RAI)-Refractory Differentiated Thyroid Carcinoma (DTC) in the First-line Setting: *Conditions*: Differentiated Thyroid Cancer (DTC); Poorly Differentiated Thyroid Cancer *Intervention*: Drug: Cabozantinib *Sponsor*: Abramson Cancer Center of the University of Pennsylvania Phase II, non-randomized, open-label study to determine the efficacy of cabozantinib as a firstline treatment for patients with differentiated thyroid cancer (DTC). Subjects will receive drug at a starting dose of 60mg PO QD. Subjects can... περισσότερα »

Erythropoietin mouthwash for the prevention of oral mucositis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Hematol Oncol. doi: 10.1002/hon.2250. *The efficacy of erythropoietin mouthwash in prevention of oral mucositis in patients undergoing autologous hematopoietic SCT: a double-blind, randomized, placebo-controlled trial.* Hosseinjani H1, Hadjibabaie M1,2, Gholami K1,2, Javadi M1,2, Radfar M1, Jahangard-Rafsanjani Z1, Hosseinjani E3, Shabani N4, Vaezi M5, Ghavamzadeh A5. Author information 1Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. 2Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran....περισσότερα »

The Impact of a Low Glycemic Index Diet on Inflammatory Markers and Serum Adiponectin Concentration in Adolescent Overweight and Obese Girls: A Randomized Clinical Trial

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα
Horm Metab Res 2016; 48: 251-256 DOI: 10.1055/s-0042-100467 Although the effects of dietary glycemic index (GI) on insulin resistance are well documented in adults, the complex interaction among glucose intolerance, inflammatory markers, and adipokine concentration has not been well studied, especially among adolescents. We investigated the effect of a low glycemic index (LGI) diet on insulin concentration, fasting blood sugar (FBS), inflammatory markers, and serum adiponectin concentration among healthy obese/overweight adolescent females. In this parallel randomized clinical tri... περισσότερα »

Adipose Tissue Dysfunction: Clinical Relevance and Diagnostic Possibilities

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα
Horm Metab Res 2016; 48: 213-225 DOI: 10.1055/s-0042-103243 Adipose tissue dysfunction is defined as an imbalance between pro- and anti-inflammatory adipokines, causing insulin resistance, systemic low-grade inflammation, hypercoagulability, and elevated blood pressure. These can lead to cardiovascular disease and diabetes mellitus type 2. Although quantity of adipose tissue is an important determinant of adipose tissue dysfunction, it can be diagnosed in both obese and lean individuals. This implies that not only quantity of adipose tissue should be used as a measure for adipose ...περισσότερα »

Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) syndrome

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
: analysis of patients from two geographic areas.: Arthritis Care Res (Hoboken). 2016 Apr 5; Authors: Batu ED, Eroğlu FK, Tsoukas P, Hausmann JS, Bilginer Y, Kenna MA, Licameli GR, Fuhlbrigge RC, Özen S, Dedeoğlu F Abstract OBJECTIVE: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is a periodic fever syndrome of childhood with an unknown etiology. Our aims were to compare the features between PFAPA patients from Turkey and the USA, and patients with and without MEFV variants, and to test the performance of the Eurofever criteria in excludi...περισσότερα »

Contour identical implants to bridge mandibular continuity defects - individually generated by LaserCUSING ®

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
- A feasibility study in animal cadavers: Abstract BackgroundAblative tumor surgery often results in continuity defects of the mandible. When an immediate reconstruction using autologous bone grafts is not possible the bridging of the defects with a variety of bridging plates might be achieved. However, those bridging plates have the risk of plate fractures or exposure. Customized titanium implants manufactured using CAD/CAM and the LaserCUSING® technique might be an alternative. MethodsIn the present study, computed tomographies (CT) of porcine cadaver mandibles were generate... περισσότερα »

Pain Control in the Presence of Drug Addiction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Pain Control in the Presence of Drug Addiction: AbstractDrug addiction is present in a significant proportion of the population in the USA and worldwide. Drug addiction can occur with the abuse of many types of substances including cocaine, marijuana, stimulants, alcohol, opioids, and tranquilizers. There is a high likelihood that clinicians will encounter patients with substance abuse disorders on a regular basis with the prevalence of the use of illicit substances and the high rate of abuse of prescription drugs. The use of abuse deterrent formulations of prescription opioid agen... περισσότερα »

Die Abhängigkeit von APHABu-Scores von Hörverlusten in Standardaudiogrammen

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Die Abhängigkeit von APHABu-Scores von Hörverlusten in Standardaudiogrammen: Laryngo-Rhino-Otol DOI: 10.1055/s-0041-111569 Hintergrund: Frageninventare, wie der APHAB (Abbreviated Profile of Hering Aid Benefit), sind neben der Ton- und Sprachaudiometrie das dritte Instrument in der primären audiologischen Diagnostik. Bislang gibt es keine Untersuchungen mit großen Fallzahlen, die einen möglichen Zusammenhang zwischen einem Hörverlust im Tonaudiogramm, repräsentiert durch standardisierte Audiogramme, und einem bestimmten Wert der APHAB-Skala vor einer Hörgeräteversorgung behandelt ... περισσότερα »

Assessment of hearing via otoacoustic emission in patients that underwent spinal anesthesia

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Assessment of hearing via otoacoustic emission in patients that underwent spinal anesthesia: *OBJECTIVE:* In this study, our aim is to show the differences between the preoperative and postoperative otoacoustic emissions (OAE) value in patients, who underwent spinal anesthesia. *PATIENTS AND METHODS:* The presented study was carried out as a randomized, double-blinded, prospective study upon the approval of Ethics Committee of Medicine School, Erciyes University. The study was conducted in accordance with the Helsinki Declaration. The study involved 39 ASA I-II patients (aged 18-6... περισσότερα »

HNO Nachrichten

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Senföle können Resistenzproblematik entschärfen Haben Sie auch eine fachliche Frage? Was steckt hinter dem therapie-resistenten Ekzem? Das beliebteste Titelbild: der Taucher der Ausgabe 3/2015 Studie zeigt Effektivität von Halspastillen mit 3-fach-Komplex Tauziehen um den „großen Wurf“ Neue Wege im Prozessrecht bei Behandlungsfehlern gefordert Bei Verdacht auf einen Behandlungsfehler steht nahezu immer der Arzt im Fokus von Gutachterkommissionen oder Gerichten. Dass häufig auch Organisationsversagen Fehlerursache sein kann, fällt dabei unter den Tisch, so ein Jurist. Eine „Pre-tri...περισσότερα »

An outcomes analysis of anterior epistaxis management in the emergency department

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
*An outcomes analysis of anterior epistaxis management in the emergency department: Many treatment options exist for the management of anterior epistaxis. However, little is known about treatment outcomes. The objective was to identify the currently utilised methods of management and outcomes... * Abstract Background *Many treatment options exist for the management of anterior epistaxis. However, little is known about treatment outcomes. The objective was to identify the currently utilised methods of management and outcomes for patients with anterior epistaxis presenting to the... περισσότερα »

Avoiding allogenic blood transfusions in endoscopic angiofibroma surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Avoiding allogenic blood transfusions in endoscopic angiofibroma surgery: Abstract Background Surgical approaches for many tumours are often limited by blood loss, exposure and risk to vital anatomical structures. Therefore, the standard of care for certain skull base tumours has become endoscopic transnasal resection. Other surgical disciplines often use cell salvage techniques, but review of the otolaryngology literature revealed very few case reports. This study investigated the value and safety of salvage-type autologous blood transfusion during the endoscopic resection o... περισσότερα »

Abnormal Injury Response in Spontaneous Mild Ventriculomegaly Wistar Rat Brains: A Pathological Correlation Study of Diffusion Tensor and Magnetization Transfer Imaging in Mild Traumatic Brain Injury

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 35 δευτερόλεπτα
Journal of Neurotrauma , Vol. 0, No. 0. from Neurology via xlomafota13 on Inoreader http://ift.tt/1N5tLuU via IFTTT

Early predictors of phonological and morphosyntactic skills in second graders with cochlear implants

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 35 δευτερόλεπτα
Publication date: August 2016 *Source:*Research in Developmental Disabilities, Volume 55 Author(s): Susan Nittrouer, Joanna H. Lowenstein, Christopher Holloman PurposeNewborn hearing screening has made it possible to provide early treatment of hearing loss to more children than ever before, raising expectations these children will be able to attend regular schools. But continuing deficits in spoken language skills have led to challenges in meeting those expectations. This study was conducted to (1) examine two kinds of language skills (phonological and morphosyntactic) at school age ...περισσότερα »

When audiovisual correspondence disturbs visual processing

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 35 δευτερόλεπτα
Abstract Multisensory integration is known to create a more robust and reliable perceptual representation of one's environment. Specifically, a congruent auditory input can make a visual stimulus more salient, consequently enhancing the visibility and detection of the visual target. However, it remains largely unknown whether a congruent auditory input can also impair visual processing. In the current study, we demonstrate that temporally congruent auditory input disrupts visual processing, consequently slowing down visual target detection. More importantly, this cross-modal inhibi... περισσότερα »

Audiovisual integration in near and far space: effects of changes in distance and stimulus effectiveness

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 35 δευτερόλεπτα
Abstract A factor that is often not considered in multisensory research is the distance from which information is presented. Interestingly, various studies have shown that the distance at which information is presented can modulate the strength of multisensory interactions. In addition, our everyday multisensory experience in near and far space is rather asymmetrical in terms of retinal image size and stimulus intensity. This asymmetry is the result of the relation between the stimulus-observer distance and its retinal image size and intensity: an object that is further away is ge... περισσότερα »

The COGs (context, object, and goals) in multisensory processing

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 35 δευτερόλεπτα
Abstract Our understanding of how perception operates in real-world environments has been substantially advanced by studying both multisensory processes and "top-down" control processes influencing sensory processing via activity from higher-order brain areas, such as attention, memory, and expectations. As the two topics have been traditionally studied separately, the mechanisms orchestrating real-world multisensory processing remain unclear. Past work has revealed that the observer's goals gate the influence of many multisensory processes on brain and behavioural responses, where...περισσότερα »

Neural correlates of tactile perception during pre-, peri-, and post-movement

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 35 δευτερόλεπτα
Abstract Tactile information is differentially processed over the various phases of goal-directed movements. Here, event-related potentials (ERPs) were used to investigate the neural correlates of tactile and visual information processing during movement. Participants performed goal-directed reaches for an object placed centrally on the table in front of them. Tactile and visual stimulation (100 ms) was presented in separate trials during the different phases of the movement (i.e. preparation, execution, and post-movement). These stimuli were independently delivered to either the ... περισσότερα »

Paramedic Lorie Burton treats a suspect, after he almost shot her husband

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
The Ohio paramedic treated and forgave the man who came inches away from killing her husband a day earlier from EMS via xlomafota13 on Inoreader http://ift.tt/1qDSigC via IFTTT

Paramedic Lorie Burton treats a suspect, after he almost shot her husband

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
The Ohio paramedic treated and forgave the man who came inches away from killing her husband a day earlier from EMS via xlomafota13 on Inoreader http://ift.tt/1qDSigC via IFTTT

Paramedic Lorie Burton treats a suspect, after he almost shot her husband

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
The Ohio paramedic treated and forgave the man who came inches away from killing her husband a day earlier from EMS via xlomafota13 on Inoreader http://ift.tt/1qDSigC via IFTTT

Mitral kapak replasmanı yapılan parkinsonlu hastada anestezi yönetimimiz- enteral l-dopa uygulaması: Olgu sunumu ve literatürlerin incelenmesi

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Mehmet Burak ESKIN, Vedat YILDIRIM, Ercan KURT. from Scope via xlomafota13 on Inoreader http://ift.tt/1S6txms via IFTTT

Intraoral lipoma – A rare case presentation

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Dr. Anusha Rangare Lakshman, Dr. Sham Kishor Kanneppady, Dr. Preethi Balan. Lipomas are the benign soft tissue neoplasms of mature adipose tissue. Most of them develop in the subcutaneous tissues, sometimes deeper tissues may be involved as well; the oral cavity is uncommonly involved. About 20% of lipomas occur in the head and neck region among which oral lipomas comprise only 1-4% of all lipomas. Oral lipomas are most commonly seen involving the major salivary glands, buccal mucosa, lip, tongue, palate, vestibule, and floor of... περισσότερα »

Radiation-Induced Angiosarcoma Following Breast Conservation Therapy: Case Report

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Doğan ALHAN, Serbülent GÜZEY, Andaç AYKAN, Ramazan YILDIZ, İsmail ŞAHİN, Selçuk IŞIK. Radiation-induced angiosarcoma is a well-known complication of radiotherapy that follows breast conservation surgery. The prognosis of angiosarcoma after radiotherapy is poor, with a 5-year survival rate of between 10-55 % and with a relapse rate of nearly 92 %. Although surgery is the main treatment option for these tumours, it may be a challenging problem because of the highly aggressive behaviour. Adjuvant and neo-adjuvant chemo/radiotherap...περισσότερα »

Breast abscess in adolescent girl: A case report

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Ahmet Bolat, Mehmet Saldır, Mustafa Gülgün, Necati Balamtekin. Breast abscess and mastitis manifest itself as erythema and increase in local temperature. While still small lesions are treated by administering a broad spectrum antibiotic. Abscess drainage may be necessary in patients who do not respond to antibiotics. Majority of the patients with breast abscess in childhood are in the neonatal period. Breast abscess are defined mostly in the neonatal age group but rarely seen in older children. In this paper, a 12 year old girl ...περισσότερα »

Celiac disease presented with recurrent invagination in a child: case report

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Necati Balamtekin, Mustafa Gülgün, Kemal Kara. Celiac Disease (CD) is gluten-sensitive, autoimmune chronic enteropathy. Diarrhea, abdominal distention, vomiting and failure to thrive are the classical symptoms of celiac disease. "Atypical" celiac disease can present with uncommon gastrointestinal findings, such as abdominal pain, constipation and non gastrointestinal manifestations. Here we report child with celiac disease presenting with recurrent small bowel intussusception. Delayed short bowel transit time and reduced motilit... περισσότερα »

Subtle Bucket-Handle Tear Of A Discoid Lateral Meniscus In A 6 Year Old Girl

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Doğan Bek, Burak Ahmet Bilekli, Tolga Ege, Servet Tunay. We report a subtle bucket-handle tear of discoid lateral meniscus causing knee extension blockage in a 6 year old girl. This rare presentation should be recognised by all orthopaedic surgeons practising arthroscopic surgery. from Scope via xlomafota13 on Inoreader http://ift.tt/1VkypZ4 via IFTTT

Evaluation of the parameters that can be effective on the response to antiviral treatment in patients with chronic hepatitis C

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal İlhan Cebeci, Alpaslan Tanoglu, Fatih Şahiner, Melih Özel, Kemal Öncü, Yusuf Yazgan, Ahmet Kemal Gürbüz, Levent Demirtürk. Chronic hepatitis C is an important public health problem due its close relationship with liver cirrhosis and hepatocellular carcinoma. Prediction of positively effective factors to chronic hepatitis C treatment gives the opportunity for the most appropriate, individualized and cost-effective treatment while preventing unnecessary and uneffective treatment interventions. In this study, we aimed to determine ... περισσότερα »

Treatment Outcomes and Associated Factors among Tuberculosis Patients in Southwest Ethiopia

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Tigist Abebe, Mulugeta Tarekegn Angamo. The aim of this study is to assess treatment outcome and associated factors among tuberculosis patients in Southwest Ethiopia. A five year general retrospective cohort was employed. Data were collected from patients' follow up record and analyzed using SPSS version 16.0(Chicago: SPSS Inc., 2007). P-value 0.05 was considered statistically significant. In the multivariate logistic regression model, age range of (35-44.9 years (AOR=6.5, 95% CI: 3.2-13.4),45-54.9 years (AOR=12.4,95% CI: 5.9-2...περισσότερα »

IONIZED CALCIUM LEVELS IN STROKE PATIENTS AND ITS’ RELATION WITH HEMIPLEGIC UPPER LIMB PAIN

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Fatih Tok, Birol Balaban, Evren Yaşar, İsmail Safaz, Bilge Yılmaz, Rıdvan Alaca.. OBJECTIVE: Our aim is to compare the ionized calcium levels between hemiplegic and normal upper limb and to investigate the relationship between forearm pain and ionized calcium levels. MATERIAL AND METHODS 24 stroke patients were included in this study. All of them have spontaneous or evoked forearm pain. Ionized serum calcium levels were analysed in both arms by taking blood from both arms at the same time. Additionally, bone minaral density of ...περισσότερα »

a heart image extramediastinally shifted to the left pulmonic area

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal cengiz öztürk, şafak yıldız. We want to present a heart image extramediastinally shifted to the middle and upper lobe of the left lung due to the former lung infection in a young patient. from Scope via xlomafota13 on Inoreader http://ift.tt/1VkypIH via IFTTT

Craniofacial Fibrous Dysplasia: A Case Report

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Andaç AYKAN, Serbülent GÜZEY, Fatih ZOR, Bülent DÜZ, Ali Fuat ÇİÇEK, Serdar ÖZTÜRK. Fibrous Dysplasia is a rare and non-familial disease of the bone. There are different forms of the disease that affect the various anatomic sites. Although the fibrous displasia patients frequently suffer from deformities and pain, there are severe functional losses could be emerged due to the localization of the disease. Because of the clinical variations of the symtomps, there is no standart treatment algoritm for the fibrous dysplasia patient... περισσότερα »

The reference ranges of neutrophil-lymphocyte ratio in different age groups

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal İbrahim AYDIN, Mehmet AĞILLI, Fevzi Nuri AYDIN, Yasemin GÜLCAN KURT, Tuncer ÇAYCI, Türker TÜRKER, Necmettin KOÇAK, Ahmet TAŞ, Tevfik HONCA, Taner ÖZGÜRTAŞ. Neutrophil-lymphocyte ratio is usually considered as an indicator of sub-clinical inflammation. In the recent studies it is observed that neutrophil-lymphocyte ratio can be used to calculate the morbidity and mortality. In this study we aimed to describe the reference values of neutrophil-lymphocyte ratio in different age groups. Patients' records were achieved with the help... περισσότερα »

Tuba-Ovarian Torsion At Second Trimester Pregnant Woman : A Case Report

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Ulaş Fidan, Uğur Keskin, Mustafa Ulubay, Fahri Burçin Fıratlıgil, Ali Ergün. The diagnosis of tubo-ovarian torsion in pregnancy period is important. Because, symptoms associated with this complication is vague. Particularly, these symptoms in second and third trimester, confusion could expose.In this article, the tubo-ovarian torsion case of a 22 weeks pregnant women offering progressive lower abdominal pain associated with anorexia and nausea was presented. The patient was performed laparatomy and the necrotic mass was removed....περισσότερα »

Congenital cyst which was observed with in patient operated for pelvic mass : case report

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Ulaş Fidan, Fahri Burçin Fıratlıgil, Mustafa Ulubay, Uğur Keskin, Ali Ergün. Paraovarian cysts are usually benign-nature lesions that develop from paramesonephric or mesonephric ducts'remnants and are commonly seen at 4th or 5th decades of life. Paraovarian cysts that are seen in adolescent period, have higher potential to be congenital. Gartner cyst is one of them. Together with gartner cysts, metanephric urinary system abnormalities can be observed. Especially, ectopic ureter, ureter duplication or ectopic kidney abnormalities... περισσότερα »

Evaluation of The Endoscope Disinfection Effectiveness of Two Different Disinfectants Composed of Benzalkonium Chloride and 0.2% Peracetic Acid

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Aslı Toklu, Aysel Gürkan, Alpaslan Tanoğlu, Muammer Kara. Aim: The aim of this study was to evaluate disinfection efficiencies of disinfectants that are made up of quaternary ammonium compounds (QAC) and 0.2% peracetic acid (PAA) in endoscope disinfection. Materials and Methods: A single-center, prospective cohort work was continued for 12 weeks. Fifty-three endoscopes disinfected with QAC and 51 endoscopes disinfected with 0.2% PAA were included in this study. Samples were collected from endoscopes at both before and after disi... περισσότερα »

Gelişimsel kalça displazisine bağlı koksartrozlu hastalarda total kalça artroplasti sonuçlarımız

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Öner Tatar, Ömer Erşen, Serkan Bilgiç, Bülent Karslıoğlu, Yüksel Yurttaş, Cemil Yıldız, Mustafa Başbozkurt. Developmental hip displasia (DHD) still presents as an important problem in our country. Latency in diagnosis and inaccurate treatment causes seconder osteoarthritis in young adults and elder patients. Variable reconstructive surgical procedures as proximal femoral and acetabular osteotomies can be performed, but the most satisfactory functional results are achieved by total hip arthroplasty (THA). In this study, we analyz... περισσότερα »

Post-Traumatic Intramural Duodenal Hematoma Due To Blunt Abdominal Trauma: Case Report

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Batuhan Hazer, Alpaslan Tanoglu, Onur Peşluk, Ayhan İnanlı. ABSTRACT: Intramural duodenal haematoma (IDH) is a very rare seen complication of healthy adults after blunt abdominal trauma which can be easily overlooked and usually treated with conservative approaches. Intramural duodenal haematoma's are most often treated non-operatively. This post-traumatic complication may occur in cases with bleeding disorders even after minor traumas. The first and most important step in the diagnosis of intramural duodenal haematoma is suspic...περισσότερα »

Psychometric evaluation of a Turkısh version of the e-health literacy scale (e-heals) in adolescent

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Sabahat Coşkun, Hatice Bebiş. The young people who are closely associated with the internet are an ideal group for the testing e health literacy measurement. The purpose of this study is to make validity and reliability of the turkısh form of e health literacy scale analysis.e- Health literacy scale was developed by Norman and Skinner ın 2006. This study is a methodologic research which is carried out between January and February 2014. This study was carried out with 100 students who are between the ages of 14-21. Data collectıo...περισσότερα »

Reliability of a spinal metastasis prognostic score to model one-year survival

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
[image: spinee57008-fig-0001.sml] Predicting survival after surgery for patients with metastatic spine disease can be challenging with multiple variables that can influence a patient's overall survival. Predictive models have been developed to assist clinicians in providing prognosis for patients. Recently, Ghori et al reported a composite model taking into account a modified Bauer score, pre-operative albumin and ambulatory status of patients with spinal metastasis. We sought to assess the reliability and validity of this composite model to predict one-year survival in patients di... περισσότερα »

Early beginning for complementary nutrition ın an infant: case report

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Necati Balamtekin, Mustafa Gülgün, Sami EKSERT. Complementary nutrition is usually advised to begin between 4 and 6 months of age. We reported an infant presenting with unknown material in her faeces diagnosed as undigested vegetable fiber due to banana fed by her mother. A 3 months-old girl was presented with with unknown material in her faeces. She was well-developed with normal percentile levels. We learned feeding her with banana by her mother the night before. Gaita microscopy was revealed undigested vegetable fibers. Her p... περισσότερα »

Minimally invasive TLIF leads to increased muscle sparing of the multifidus muscle but not the longissimus muscle compared with conventional PLIF- a prospective randomized clinical trial

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
The authors have prospectively compared two groups of patients following posterior/transforaminal interbody fusion through either a midline (traditional) approach or a Wiltse incision (MIS approach). They studied the changes in the paraspinal musculature using a CT-based technique to evaluate volume atrophy and fatty degeneration following surgery at the index and adjacent levels. Radiographic changes were studied at the 1-week and 12-month time points and clinical parameters were compared at the preoperative, 1-week and 12-month time points. from Sports Medicine via xlomafota13 o...περισσότερα »

A Rare Cause of Ascites: Multiple Myeloma

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 36 δευτερόλεπτα
2016-04-11T21-06-54Z *Source:* Gulhane Medical Journal Kadir Ozturk, Gurkan Celebi, Gokhan Ozgur,Hakan Demirci, Guldem Kilciler. A 65 year old male patient who have diagnosis of multiple myeloma for three months. The abdominal ultrasonography was performed upon development of swelling in the abdomen and legs prior to the third cycles of chemotherapy treatment. On ultrasonographic examination the liver was normal but there was free fluid in abdomen. In cytological examination of ascites fluid atypical plasma cell was not detected but Ig G Kappa type monoclonal gammopathy was detected... περισσότερα »

Workplace Drug Testing: An Overview of the Current Situation

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα
The post Workplace Drug Testing: An Overview of the Current Situation appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Vj6fNG via IFTTT

Methemoglobinemia

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα
Methemoglobinemia: The presence in the blood of methemoglobin, a form of hemoglobin that is useless for carrying oxygen and delivering it to tissues throughout the human body. A small amount of methemoglobin is normally present in blood but the conversion of a larger fraction of hemoglobin into methemoglobin, which does not function well as an… Continue reading Methemoglobinemia

Hepatocyte nuclear factor 6 inhibits the growth and metastasis of cholangiocarcinoma cells by regulating miR-122

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα
Abstract Purpose Hepatocyte nuclear factor 6 (HNF6) is a liver-enriched transcription factor and highly expressed in mature bile duct epithelial cells. This study sought to investigate the role of HNF6, particularly the molecular mechanisms for how HNF6 is involved in the growth and metastasis of cholangiocarcinoma (CCA) cells. Methods The expression of HNF6, miR-122 and… Continue reading Hepatocyte nuclear factor 6 inhibits the growth and metastasis of cholangiocarcinoma cells by regulating miR-122

Tumor characteristics and therapy of elderly patients with breast cancer

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα
Abstract Introduction Elderly breast cancer patients aged ≥75 years are underrepresented in most studies. Therefore, data on cancer characteristics, adjuvant treatment and survival in elderly patients are missing. Patients and methods In this retrospective study, we compared tumor characteristics and adjuvant therapy in 973 women with invasive, non-metastasized breast cancer aged ≥75 years with 3377… Continue reading Tumor characteristics and therapy of elderly patients with breast cancer

IRON MAIDEN Drummer Says Frontman Beating Cancer Caused Him To Sober Up – Metal Injection.net

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα
Metal Injection.net IRON MAIDEN Drummer Says Frontman Beating Cancer Caused Him To Sober Up Metal Injection.net Back in 2015, Iron Maiden vocalist Bruce Dickinson had a battle with tongue cancer. Fortunately for himself, his family, friends, and fans, he came out on the winning side and the band released The Book of Souls. Being that… Continue reading IRON MAIDEN Drummer Says Frontman Beating Cancer Caused Him To Sober Up – Metal Injection.net

Are there different factors affecting walking speed and gait cycle variability between men and women in community-dwelling older adults?

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα
Abstract Background Few studies have examined the relationships between walking speed and gait cycle variability, and muscle strength and postural stability, with a focus on gender differences. Aim The aim of this study was to examine whether there are different factors affecting walking speed and gait cycle variability between men and women in community-dwelling older… Continue reading Are there different factors affecting walking speed and gait cycle variability between men and women in community-dwelling older adults?

Galectin-3 in bone tumor microenvironment: a beacon for individual skeletal metastasis management

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα
Abstract The skeleton is frequently a secondary growth site of disseminated cancers, often leading to painful and devastating clinical outcomes. Metastatic cancer distorts bone marrow homeostasis through tumor-derived factors, which shapes different bone tumor microenvironments depending on the tumor cells’ origin. Here, we propose a novel insight on tumor-secreted Galectin-3 (Gal-3) that controls the induction… Continue reading Galectin-3 in bone tumor microenvironment: a beacon for individual skeletal metastasis management

Understanding the cellular roles of Fyn-related kinase (FRK): implications in cancer biology

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα
Abstract The non-receptor tyrosine kinase Fyn-related kinase (FRK) is a member of the BRK family kinases (BFKs) and is distantly related to the Src family kinases (SFKs). FRK was first discovered in 1993, and studies pursued thereafter attributed a potential tumour-suppressive function to the enzyme. In recent years, however, further functional characterization of the tyrosine… Continue reading Understanding the cellular roles of Fyn-related kinase (FRK): implications in cancer biology

The dangers to children from coconut tree trauma, in KiraKira, Solomon Islands: a retrospective clinical audit

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα
Kirakira is small community of 3,000 people and is the capital of Makira-Ulawa province in Solomon Islands. Kirakira is an impoverished community with a small 30 bed hospital with limited resources. This audit… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TO0SVr via IFTTT

Clinical response to ruxolitinib in CSF3R T618 -mutated chronic neutrophilic leukemia

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 36 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Wnjgp5 via IFTTT

Local brain FC is increased in the acute hypothyroid state. Higher FC correlates with a poorer mental QoL and increased depression in the hypothyroid state.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Diminished Quality of Life and Increased Brain Functional Connectivity in Patients with Hypothyroidism After Total Thyroidectomy: [image: access_free.gif] Thyroid , Vol. 0, No. 0. Author information Yong-Wook Shin,1 Yun Mi Choi,2 Ho Sung Kim,3 Dae-Jin Kim,4 Hang Joon Jo,5 Brian F. O'Donnell,4 Eun Kyung Jang,2 Tae Yong Kim,2 Young Kee Shong,2 Jin Pyo Hong,6 and Won Bae Kim2 1Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. 2Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul,... περισσότερα »

Risk Factors Predicting Infectious Lactational Mastitis: Decision Tree Approach versus Logistic Regression Analysis

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 39 δευτερόλεπτα
Abstract *Objectives* Lactational mastitis frequently leads to a premature abandonment of breastfeeding; its development has been associated with several risk factors. This study aims to use a decision tree (DT) approach to establish the main risk factors involved in mastitis and to compare its performance for predicting this condition with a stepwise logistic regression (LR) model. *Methods* Data from 368 cases (breastfeeding women with mastitis) and 148 controls were collected by a questionnaire about risk factors related to medical history of mother and infant, pregnancy, deliv...περισσότερα »

Seronegative autoimmune hepatitis in children: Spectrum of disorders

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 39 δευτερόλεπτα
A few children with acute or chronic liver disease display histological features compatible with autoimmune hepatitis, but lack specific serological markers. from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1ViJWaL via IFTTT

Avoiding allogenic blood transfusions in endoscopic angiofibroma surgery

Surgical approaches for many tumours are often limited by blood loss, exposure and risk to vital anatomical structures. Therefore, the standard of care for certain skull base tumours has become endoscopic tran… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YqUYcb via IFTTT

An outcomes analysis of anterior epistaxis management in the emergency department

Many treatment options exist for the management of anterior epistaxis. However, little is known about treatment outcomes. The objective was to identify the currently utilised methods of management and outcomes… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1MqOkSE via IFTTT

Creating chemotherapeutic-resistant breast cancer cell lines: advances and future perspectives

Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SuVwZU via IFTTT

Creating chemotherapeutic-resistant breast cancer cell lines: advances and future perspectives

Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SuVwZU via IFTTT

Systematic Review of Dietary Interventions Targeting Sleep Behavior

The Journal of Alternative and Complementary Medicine , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/23qsAhe via IFTTT

Coexistence of Multiple Ileal Neuroendocrine Tumors and Idiopathic Myointimal Hyperplasia of Mesenteric Veins: Coincidence or Consequence? Case Report and Review of Literature

In the present case, we report the association of multiple ileal neuroendocrine tumors and idiopathic myointimal hyperplasia of the mesenteric veins, 2 rare conditions that could have an etiopathogenetic relationship. Idiopathic myointimal hyperplasia of mesenteric veins implies a near-total obliteration of venular vessels, which can lead to hypoxic disorders. Hypoxia in tumors is associated with […]

Thyrosaurus Colloidus

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qkGcZu via IFTTT

Solid Variant of Adenoid Cystic Carcinoma: Difficulties in Diagnostic Recognition

Adenoid cystic carcinoma (ACC) is a malignant neoplasm that mainly affects the salivary glands but has been described in many other anatomical sites. It is composed of basaloid cells with myoepithelial/basal cell differentiation and ductal epithelial cells that proliferate in a fibrous stroma, with variable amounts of myxohyaline material. Three patterns (cribriform, tubular, and solid) […]

Bowtie technique—a novel approach to correct the widened ventral labia majora after male-to-female gender reassi gnment surgery

Abstract Male-to-female gender reassignment surgery is a procedure that has evolved significantly since its inception. To create an aesthetic and functional vagina is the primary focus. Despite its evolutions, second stage revisions are frequently utilised to correct labial and clitoral hood defects (e.g. loss of clitoral hood, widening of the ventral labia major and exposure […]

Novel microvascular anastomosis between a single vessel and two downstream vessels

Abstract Microsurgeons rarely encounter a situation that includes multiple downstream arteries requiring reperfusion with only one feeding artery being available. To cope with the difficulty of such a case, a unique microvascular anastomosis is described. This surgical technique is based on the assumption of the presence of a single large outflowing vessel and two small […]