Endoscopic Strip Craniectomy for Craniosynostosis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Endoscopic Strip Craniectomy for Craniosynostosis: Do We Really Understand the Indications, Outcomes, and Risks?: [image: image]Abstract: Endoscopic strip craniectomy with postoperative helmet therapy has been introduced as a means to correct various forms of craniosynostosis. Although some authors have deemed the procedure safe and effective, many questions remain regarding this promising yet developing approach. The authors discuss 4 cases where patients were inadequately treated with endoscopic strip craniectomy resulting in a recommendation of complete secondary open cranial v... περισσότερα »
Oxygen Saturation and Heart Rate During Intraoral Impression Taking in Infants With Cleft Lip and Palate
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Evaluation of Oxygen Saturation and Heart Rate During Intraoral Impression Taking in Infants With Cleft Lip and Palate: Abstract Objective: The aim of the study was to evaluate the changes in oxygen saturation and heart pulse during intraoral impression taking from infants with cleft lip and palate (CLP) at onset of presurgical orthopedic therapy. Subjects and Methods: In our study, 21 uni- and bilateral infants with CLP (9 female, 12 males, mean age 5.90 ± 2.46 days) were monitored and heart pulse and oxygen saturation were measured under operating conditions before any interventio...περισσότερα »
Surgical Optimization of Motor Recovery in Face Transplantation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Surgical Optimization of Motor Recovery in Face Transplantation: Background: Face transplantation (FT) has emerged as a viable option for treating devastating facial injuries. Most reported outcomes have demonstrated satisfactory motor and sensory restoration despite differences in technique. The authors have developed an algorithm of facial nerve management in these challenging patients. Our principles of management are illustrated by 2 specific patients. Methods: A retrospective analysis of prospectively collected data on 2 full face transplants was performed. Both patients requir... περισσότερα »
Infratemporal Fossa Abscess
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Infratemporal Fossa Abscess of Dental Origin: A Rare, Severe, and Misdiagnosed Infection: [image: image]
Living altitude influences endurance exercise performance change over time at altitude
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
For sea level based endurance athletes who compete at low and moderate altitudes, adequate time for acclimatization to altitude can mitigate performance declines. We asked whether it is better for the acclimatizing athlete to live at the specific altitude of competition or at a higher altitude, perhaps for an increased rate of physiological adaptation. After 4wks of supervised sea level training and testing, 48 collegiate distance runners (32M, 16W) were randomly assigned to one of four living altitudes (1780m, 2085m, 2454m, or 2800m) where they resided for 4wks. Daily training fo... περισσότερα »
Vitamin D3 Intake Modulates Diaphragm but not Peripheral Muscle Force in Young Mice
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Recent data support an important role for vitamin D in respiratory health. We tested the hypothesis that dietary Vit D3 (VD3) intake modulates diaphragm (DIA) strength. Four-week old female A/J mice (n=10/group) were randomized to receive diets containing 100 IU VD3/kg (low), 1,000 IU VD3 /kg (reference), or 10,000 IU VD3/kg (pharmacologic). After 6 weeks of dietary intervention, plasma 25-hydroxyvitamin D3 (25D3) levels, DIA and extensor digitorum longus (EDL) in-vitro contractile properties, and fiber cross sectional area (CSA) were measured. Myosin heavy chain (MHC) composition... περισσότερα »
Intermittent severe hypoxia induces plasticity within serotonergic and catecholaminergic neurons in the neonatal rat ventrolateral medulla
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
5-HT neurons contribute to autoresuscitation and survival during intermittent severe hypoxia (IsH). In adults, catecholaminergic neurons in the ventrolateral medulla (VLM) contribute to the autonomic response to hypoxia. We hypothesized that: 1) catecholaminergic neurons in the neonatal VLM are activated following IsH; 2) this activation is compromised following an acute loss of brainstem 5-HT, and 3) IsH induces cellular and/or transcriptomic plasticity within catecholaminergic and serotonergic neurons that are within or project to the VLM, respectively. To test these hypotheses ...περισσότερα »
98. Correlations between P300, MRI parameters and neuropsychological tests in multiple sclerosis patients
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
We aimed to evaluate the correlations among event-related evoked potentials (ERPs), neuropsychological and neuroradiological parameters in multiple sclerosis (MS) patients. We studied 10 patients with definite MS (6 males, 4 females, average age 43.6, SD=11.3), and moderate disability (EDSS 2.85, SD=1.45; range: 1.0–6.0). All patients underwent standardized neuropsychological tests, P300 evoked potentials study, and MRI. Registration of ERPs (P300) was performed by random double auditory discrimination task paradigm, recorded through scalp electrodes placed at Fz, Cz and Pz and link... περισσότερα »
97. Event related potentials recorded by intracerebral electrodes
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Preoperative evaluation, by means of intracerebral electrodes, provides an opportunity to explore neural generators of ERPs and also N140 (a long latency SEP that is modulated by attention manipulations). We studied 5 pediatric patients with drug resistant epilepsy. ERPs and SEPs (to median and tibial nerve stimulation) were recorded from the intracerebral electrode contacts referred to the earlobe ipsilateral to the stimulation. The analysis was addressed to the electrode contacts where an inversion of neurophysiological component polarity was observed, or where the EP amplitude wa... περισσότερα »
8. Evaluation of counselling received by women with epilepsy in their reproductive years and management in pregnancy
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
The primary outcome of the study was to evaluate whether women with epilepsy (WWE) of reproductive age received counselling before conception, including issues such as folate supplementation, antiepileptic drug selection (AED) and their potential teratogenic risks. from Physiology via xlomafota13 on Inoreader http://ift.tt/1TQIv3l
9. The anticonvulsant effects of cannabidiol examined in animal seizure models
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Cannabidiol (CBD), a major nonpsychotropic compound of Cannabis sativa, is emerging as a treatment for intractable seizures and their comorbid cognitive, behavioral and quality of life sequelae. Basic research studies in animals have started to define the anticonvulsant properties of CBD. Studies of CBD in mice and rats using maximal electroshock (MES) and pentylenetetrazol (PTZ) models of generalized clonus or myoclonus reported ED50 values of CBD as early as the 1970s – however chromatographic analysis of CBD purity was often not reported. from Physiology via xlomafota13 on Inorea...περισσότερα »
1. A meta-analysis of the cortical silent period in epilepsies
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
The cortical silent period (CSP) following transcranial magnetic stimulation reflects GABAB-mediated inhibition in the primary motor cortex (M1), and could contribute to understand the pathophysiological substrates of epilepsies. Increased CSP duration has been reported in idiopathic generalized epilepsy (IGE) and in partial epilepsy (PE) involving the M1, although other studies yielded discordant findings. In this meta-analysis we systematically assessed the consistency of CSP changes in untreated epileptic patients. from Physiology via xlomafota13 on Inoreader http://ift.tt/1TQIxbh
47. Autonomic dysfunction in ALS patients: An early phase study_preliminary data
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Amyotrophic Lateral Sclerosis (ALS) is a fatal degenerative motoneuron disease. Since 40years, study investigating a possible Autonomic Nervous System (ANS) involvement are reported. Although results are contradictory and studies difficult to compare, ALS appears not to be a single disease entity, but a spectrum of disorders involving mainly, but not only, motoneurons. The aim of the study was to investigate cardiovascular ANS function in ALS patients with low disability and normal respiratory function. from Physiology via xlomafota13 on Inoreader http://ift.tt/1RTWKAt
2. Follow-up of five cases with Rasmussen encephalitis with magnetoencephalography
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Magnetoencephalography (MEG) recordings of interictal and/or ictal discharges can provide valuable information about the location of the epileptogenic area in the brain. Rasmussen Encephalitis (RE) is characterized by intractable epilepsy, progressive hemiparesis, and unilateral hemispheric atrophy. The progression of the symptoms to significant neurological impairment usually occurs within months to a few years. Five patients (mean age at first observation 7.6±3years) fitting Bien’s criteria for the diagnosis of RE were enrolled for the study and follow-up for at least 1.5years (4–... περισσότερα »
39. CMAP area variability is a function of area size
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
We studied the relationship between CMAP area variability and CMAP area size in an experimental setting in which any other possible cause of variability was removed.In 10 normal volunteers we recorded from Abductor Digiti Minimi a CMAP of large area and one of small area simultaneously after maximal stimulation of the ulnar nerve at wrist. Ulnar nerve stimulation was repeated 5 times, 4-6s apart, and two sets of 5 CMAPs were obtained: one of large area and one of small area. The same procedure was performed with stimulation of the ulnar nerve at the elbow. from Physiology via xlomaf... περισσότερα »
3. Evaluation of long term cognitive risks associated with the presence of seizure during acute disseminated encephalomyelitis
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
A small percentage of paediatric acute disseminated encephalomyelitis (ADEM) presents with seizures. The association of epileptic activity with demyelination could represent an increased risk for long-lasting cognitive sequelae; however, this risk has not yet been explored in the literature. Objective of this study was to compare long-term neuropsychological outcomes among children and adolescents with history of ADEM with or without seizures. A neuropsychological evaluation (explored areas: general intelligence, language, attention, memory, visuo-motor skills and executive function... περισσότερα »
55. Selective stimulation of A delta fibres by micropatterned interdigitated surface electrodes
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Electrophysiological assessment of the nociceptive pathway is a difficult task, just recently accomplished by laser stimulators, which only activate pain endings. Unfortunately, there are several drawbacks to this type of stimulus, for its costly generator, for the possible skin lesions and difficult handling. Electric stimuli are far more easy to generate and deliver, but they lack the necessary selectivity. We demonstrate here that by using a bipolar comb like electrode where multiple rails of opposite polarity are only distant 50μm (Pat. from Physiology via xlomafota13 on Inoread... περισσότερα »
4. Neurophysiological pattern related to recovery of responsiveness in patients with disorders of consciousness after cardiac arrest
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Most of the patients who survive after a cardiac arrest (CA) recover responsiveness in the first 30–40 days, even if further recovers are possible also in the following months. We conducted a prospective study to correlate the recovery of consciousness with EEG and somatosensory evoked potentials (SEP) findings. The level of consciousness was evaluated by means of the Coma Recovery Scale Revised. 22 inpatients (12 VS, 6 low grade MCS, 4 high grade MCS) were followed for a mean of 200 days (range 112–300days) since CA. from Physiology via xlomafota13 on Inoreader http://ift.tt/1TQIuMT
35. Vestibular-coclear nerve involvement in Charcot–Marie–Tooth disease: A pilot-study
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Some authors suggested a multifactorial genesis of imbalance in patient affected by Charcot–Marie–Tooth disease (CMT) caused not only by reduced proprioceptive input but also by a vestibular impariment. Nowadays no neurophysiological studies have been performed to support this hypothesis. Aim of our pilot case-control study is to determine the prevalence of vestibular coclear nerve involvement in patients affected by CMT. Second aim is to compare the severity of vestibular coclear neuropathy among the neurophysiological subtypes of CMT (nominated as demyelinating, axonal or intermed...περισσότερα »
5. Psychophysiological responsivity and conscious appraisal of affective stimuli in non-organic syncope
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Transient losses of consciousness and muscular tone that characterize syncope are due to a sudden decrease of blood flow to the brain. Nevertheless, in part of patients reporting syncope episodes, the classic diagnostic process does not lead to a proper organic etiology – e.g. neutrally mediated or cardiac. Psychological non-organic factors like emotional dysregulation or anxiety mechanisms might act as triggers for those clinical manifestations. Given the link between affective experience and sympathetic-parasympathetic autonomic system, this research aims at investigating the hypo... περισσότερα »
43. Pain-related cortex function in patients with Alzheimer’s disease. Preliminary results
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Previous studies found that patients with Alzheimer’s disease (AD) have increased pain threshold and pain tolerance. Nevertheless it is still unclear whether these findings are explained by communication problems, or rather they are associated with degenerative processes affecting pain-related cortex. In this neurophysiological study we aimed at assessing pain-related cortex function, by recording laser evoked potentials (LEPs) after hand stimulation in patients with AD. We enrolled 10 patients with a diagnosis of probable mild-to-moderate AD, recruited from the Alzheimer Evaluation...περισσότερα »
6. Sensory-motor networks’ topology in multiple sclerosis fatigue
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
The large majority (80%) of people with multiple sclerosis (MS) complain of fatigue, which is the most disabling symptom in half of them. While the few drugs used to treat MS fatigue are limitedly useful, it was recently observed the efficacy of a personalized neuromodulation treatment, supporting the concept that interventions modifying the sensorimotor network activity balances could be suitable non-pharmacological treatments for MS fatigue. Aim of the present study is to strengthen knowledge of the brain unbalances, which proper neuromodulations should target to compensate. from ... περισσότερα »
51. Hand somatosensory Functional Source Separation (FSS) analysis reveals hypoactive sub-cortical source signals in migraine interictally
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Recent morpho-functional evidences pointed out that abnormalities in the thalamus could play a major role in the expression of migraine neurophysiological and clinical correlates. To this aim, we used Functional Source Separation algorithm to extract, from EEG signals, the activity of different neuronal pools recruited at different latencies along the somatosensory pathway in interictal migraine without aura (MO) patients. Twenty MO patients and twenty healthy volunteers (HV) underwent EEG recording. from Physiology via xlomafota13 on Inoreader http://ift.tt/1QIG7HL
7. EEG characteristics in “eyes open” vs “eyes closed” conditions: Small world network architecture in healthy aging and age-related brain degeneration
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Applying graph theory, we investigated how cortical sources small worldness (SW) of resting EEG in eyes-closed/open (EC/EO) differs in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) subjects respect to normal elderly (Nold). EEGs were recorded in 30 Nold, 30 MCI, 30 AD during EC and EO. Undirected and weighted cortical brain network was built to evaluate graph core measures. eLORETA lagged linear connectivity was used to weight the network. In Nold, EO condition presented more random network (higher SW) in alpha bands and more regular organization (lower SW) in beta2 an... περισσότερα »
59. Variability in response to 1Hz repetitive TMS
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
Responses to different plasticity-inducing brain stimulation protocols are highly variable. However, there are few data available on the variability of response to 1Hz repetitive transcranial magnetic stimulation (1Hz rTMS). We tested the effects of 1Hz rTMS over the motor cortex on corticospinal excitability. We examined whether an individual’s response could be predicted from measurements of motor evoked potential (MEP) latency following stimulation with different orientations of TMS. Thirty-two healthy subjects participated in a crossover-design. from Physiology via xlomafota13 o... περισσότερα »
8. Autonomic correlates of seeing one’s own face in patients with disorders of consciousness
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
The ability to recognize one’s own face, or “self-face”, is a hallmark of self-awareness. In healthy subjects, the sympathetic skin response (SSR) evoked by self-face recognition has a greater area than responses evoked by other visual stimuli. We evaluated the SSRs evoked by self-face images and by six other visual stimuli (conditions) in 15 patients with severe disorders of consciousness and in 15 age-matched healthy subjects. Under all conditions, the evoked area of the SSR was smaller in patients with unresponsive wakefulness syndrome (UWS), intermediate in patients in a minimal... περισσότερα »
33. A rare case of Guillain–Barre’ syndrome and pseudotumor cerebri, with normal cerebrospinal fluid protein
Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
A 19years old female patient was referred for assessment of head and cervical pain, upper limbs dysesthesias, diplopia, visual impairment (mainly in left eye) and postural instability. Initial examination revealed left ptosis, left abducent nerve palsy, diffuse hyporeflexia and limb ataxia. At admission lumbar puncture was performed with a normal cerebrospinal fluid analysis and a temporal dispersion of F waves and Skin Reflex was observed by electromyography. In suspicion of a Guillain–Barré syndrome a IV immunoglobulin treatment was administered. from Physiology via xlomafota13 on...περισσότερα »
International Fellowships.The Tsao Fellowship in Global Health
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
The Tsao Fellowship in Global Health: A Model for International Fellowships in a Surgery Residency: Objective: To present a model for integrated global health fellowships in plastic surgical residency training. Background: National surveys have found that North American surgical residents have significant interest in international training. While global health training opportunities exist, less than a third of these are housed within surgical residency programs; even fewer are designed specifically for plastic surgery residents. Methods: The Tsao Fellowship was created through a par... περισσότερα »
Focusing Quality Improvement Initiatives in Pediatric Plastic Surgery: A Descriptive Study Using the Pediatric National Surgical Quality Improvement Program
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
Focusing Quality Improvement Initiatives in Pediatric Plastic Surgery: A Descriptive Study Using the Pediatric National Surgical Quality Improvement Program: Background: The American College of Surgeons National Surgical Quality Improvement Program - Pediatrics uses a risk-adjusted, case-mix-adjusted methodology to compare quality of hospital-level surgical performance. This paper aims to focus quality improvement efforts on diagnoses that have large patient volume and high morbidity for pediatric plastic surgery. Methods: Frequency statistics were generated for a cohort of patients...περισσότερα »
Salvage Free Anterolateral Thigh Composite Flap Transfer Based on the Musculocutaneous Perforator Retrograde Blood Flow Principle
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Salvage Free Anterolateral Thigh Composite Flap Transfer Based on the Musculocutaneous Perforator Retrograde Blood Flow Principle: [image: image]Abstract: An anterolateral thigh myo-adipofascial flap was used in the definitive management of a patient presented with chronic infective process associated with a large fronto-nasal defect. Unfortunately, the risk of free flap transfer failure emerged when intraoperative dissection showed absence of a reliable ipsilateral superficial temporal artery as the recipient artery. This rare incident happened at the stage whereby the anterolateral... περισσότερα »
The Emotional Brain as a Predictor and Amplifier of Chronic Pain
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
The Emotional Brain as a Predictor and Amplifier of Chronic Pain: Human neuroimaging studies and complementary animal experiments now identify the gross elements of the brain involved in the chronification of pain. We briefly review these advances in relation to somatic and orofacial persistent pain conditions. First, we emphasize the importance of reverse translational research for understanding chronic pain—that is, the power of deriving hypotheses directly from human brain imaging of clinical conditions that can be invasively and mechanistically studied in animal models. We then... περισσότερα »
High intensity noise on the vestibular system
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Effects of high intensity noise on the vestibular system in rats via Hearing Research [image: alertIcon.gif] Publication date: Available online 10 March 2016 *Source:*Hearing Research Author(s): Courtney Stewart, Yue Yu, Jun Huang, Adel Maklad, Xuehui Tang, Jerome Allison, William Mustain, Wu Zhou, Hong Zhu Some individuals with noise-induced hearing loss (NIHL) also report balance problems. These accompanying vestibular complaints are not well understood. The present study used a rat model to examine the effects of noise exposure on the vestibular system. Rats were exposed to continuou... περισσότερα »
Pulsatile electrical stimulation of the round window on central hyperactivity after cochlear trauma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Effects of pulsatile electrical stimulation of the round window on central hyperactivity after cochlear trauma in guinea pig via Hearing Research [image: S03785955.gif] Publication date: Available online 10 March 2016 *Source:*Hearing Research Author(s): W.H.A.M. Mulders, T.C. Spencer, D. Robertson Partial hearing loss induced by acoustic trauma has been shown in animal models to result in an increased spontaneous firing rate in central auditory structures. This so-called hyperactivity has been suggested to be involved in the generation of tinnitus, a phantom auditory sensation. Alth... περισσότερα »
Evidence-based guidelines for recommending cochlear implantation for postlingually deafened adults
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Evidence-based guidelines for recommending cochlear implantation for postlingually deafened adults: 10.3109/14992027.2016.1146415<br>Jaime R. Leigh Abstract *Objective*: Adult selection criteria for cochlear implantation have been developed based on analysis of the post-operative performance of a large group of postlingually deafened adults. Original criteria published in 2004 were reviewed and amended to reflect outcomes currently being achieved by implant recipients. *Design*: Retrospective review of 12-month post-operative speech perception performance of adults implanted at ... περισσότερα »
Comorbidities and recurrence of benign paroxysmal positional vertigo
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
: personal experience by P. M. Picciotti via International Journal of Audiology: Table of Contents: Taylor and Francis 10.3109/14992027.2016.1143981 P. M. Picciotti Abstract *Objective*: The aim of this study is to evaluate the correlation between clinical features of benign paroxysmal positional vertigo (BPPV) and age, sex, trauma, presence of one or more comorbidities such as cardiovascular, neurological, endocrinological, metabolic, psychiatric diseases. *Design:* Retrospective review of medical records (chart review). *Study sample*: A total of 475 patients aged from 14 to 87 ye...περισσότερα »
Psychometric properties of a Mandarin version of the tinnitus questionnaire
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Psychometric properties of a Mandarin version of the tinnitus questionnaire: 10.3109/14992027.2016.1146414<br>Zhaoli Meng Abstract *Objective*: To develop a Mandarin version of the tinnitus questionnaire (MTQ) and determine the reliability and validity, and to assess whether it could be used clinically in the Chinese population. *Design*: The MTQ, short-form (36) health survey, hospital anxiety and depression scale, Mandarin (Chinese) tinnitus handicap inventory, and visual analogue scale were completed by the participants. *Study sample*: We included 192 adults seeking treatmen... περισσότερα »
D-methionine (D-met) significantly reduces kanamycin-induced ototoxicity
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
D-methionine (D-met) significantly reduces kanamycin-induced ototoxicity in pigmented guinea pigs: 10.3109/14992027.2016.1143980<br>Kathleen C. M. Campbell Abstract *Objective:* Test D-methionine (D-met) as an otoprotectant from kanamycin-induced ototoxicity and determine the lowest maximally protective D-met dose. *Design:* Auditory brainstem responses (ABR) were measured at 4, 8, 14, and 20 kHz at baseline and two, four, and six weeks after kanamycin and D-met administration initiation. ABR threshold shifts assessed auditory function. Following six-week ABR testing, animals we... περισσότερα »
Evaluación del cambio en el umbral de la vía ósea en pacientes operados de estapedectomía
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Evaluación del cambio en el umbral de la vía ósea en pacientes operados de estapedectomía via Acta Otorrinolaringológica Española Publication date: Available online 9 March 2016 *Source:*Acta Otorrinolaringológica Española Author(s): Leire García-Iza, Juan José Navarro, Miren Goiburu, Nuria Pérez, Xabier Altuna Introducción y objetivosLa alteración del umbral auditivo de la vía ósea no solo corresponde a enfermedad localizada en el oído interno y nervio coclear, sino que puede ser secundaria a enfermedad presente en el oído medio, como ocurre en la otosclerosis.El objetivo de este est... περισσότερα »
High Frequency Ex Vivo Ultrasound Imaging of the Middle Ear to Show Simulated Ossicular Pathology.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
High Frequency Ex Vivo Ultrasound Imaging of the Middle Ear to Show Simulated Ossicular Pathology.: Hypothesis: To illustrate the ability of high frequency ultrasound (HFUS) using a transducer array to demonstrate a variety of simulated clinical scenarios involving the ossicular chain. Background: HFUS (>20 MHz) is a relatively new area of ultrasonic imaging that provides an order of magnitude better image resolution than the conventional low-frequency systems. HFUS may be a real-time imaging system that could be used in the clinic and would complement computed tomography (CT) and m... περισσότερα »
Emergence of Binaural Summation After Surgical Correction of Unilateral Congenital Aural Atresia.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Emergence of Binaural Summation After Surgical Correction of Unilateral Congenital Aural Atresia.: Objective: To investigate the emergence of binaural summation in patients with unilateral congenital aural atresia undergoing surgical correction. Study Design: Preoperative and postoperative audiometric testing in a prospective cohort of 10 patients with unilateral congenital aural atresia. Setting: University-based tertiary care center. Patients: Ten patients (ages 6-53) with an average 69 dB (+/-9 dB sd) unilateral conductive hearing loss, normal hearing in the nonatretic ear, and ... περισσότερα »
Cost-Utility Analysis of Cochlear Implantation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Cost-Utility Analysis of Cochlear Implantation in Australian Adults.: Objectives: Sequential and simultaneous bilateral cochlear implants are emerging as appropriate treatment options for Australian adults with sensory deficits in both cochleae. Current funding of Australian public hospitals does not provide for simultaneous bilateral cochlear implantation (CI) as a separate surgical procedure. Previous cost-effectiveness studies of sequential and simultaneous bilateral CI assumed 100% of unilaterally treated patients' transition to a sequential bilateral CI. This assumption does not... περισσότερα »
Pediatric Bilateral Severe to Profound Sensorineural Hearing Loss
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Economic Evaluation of Treatments for Pediatric Bilateral Severe to Profound Sensorineural Hearing Loss: An Australian Perspective.: Objectives: In Australia, surgical treatment options for children with bilateral severe to profound sensorineural hearing loss exist in a continuum ranging from unilateral cochlear implantation (CI), sequential bilateral CI through to simultaneous bilateral CI, depending on the condition. When treatment options are mutually exclusive, the mean costs and benefits of each treatment group are summed together to obtain the total mean costs and benefits. Th... περισσότερα »
Evaluation of Oxygen Saturation and Heart Rate During Intraoral Impression Taking in Infants With Cleft Lip and Palate
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Objective: The aim of the study was to evaluate the changes in oxygen saturation and heart pulse during intraoral impression taking from infants with cleft lip and palate (CLP) at onset of presurgical orthopedic therapy. Subjects and Methods: In our study, 21 uni- and bilateral infants with CLP (9 female, 12 males, mean age 5.90 ± 2.46 […]
Endoscopic Strip Craniectomy for Craniosynostosis: Do We Really Understand the Indications, Outcomes, and Risks?
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Abstract: Endoscopic strip craniectomy with postoperative helmet therapy has been introduced as a means to correct various forms of craniosynostosis. Although some authors have deemed the procedure safe and effective, many questions remain regarding this promising yet developing approach. The authors discuss 4 cases where patients were inadequately treated with endoscopic strip craniectomy resulting in […]
Dentures as Learning Materials for Maxillomandibular Fixation by Erich Arch Bars
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Abstract: Maxillomandibular fixation with Erich arch bars is an economic method for handling mandibular fractures. Unfortunately, this method has some disadvantages, such as long operating time, periodontal trauma, and risk of puncture injury to the operator. To overcome these disadvantages, we propose teaching the pits and pearls of maxillomandibular fixation with Erich arch bars to […]
The Management of Nonsyndromic, Isolated Sagittal Synostosis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Aim: Isolated sagittal synostosis is the commonest form of craniosynostosis. The reasons for surgery are to normalize the head shape and to increase the cranial volume, thus reducing the risk of raised intracranial pressure and allowing for normal brain development. It has been suggested that sagittal synostosis may impair neuropsychological development. This systematic review appraised […]
A Huge Ancient Schwannoma of the Epiglottis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Abstract: Ancient schwannoma of the epiglottis is extremely rare. The authors report the first case of a patient with a huge ancient schwannoma of the epiglottis. Clinicians should consider the possibility that ancient schwannoma may originate in the epiglottis mimicking the other more frequently observed lesions. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1MaMXBK via IFTTT
Comparison of Nasal Septum and Ear Cartilage as a Graft for Lower Eyelid Reconstruction
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Abstract: In lower eyelid reconstruction, several types of grafts from the nasal septum, ear cartilage, buccal mucosa, and hard palate mucosa have been used for an inner layer of the lower eyelid, but there have been no studies comparing these grafts. The authors retrospectively reviewed our cases of lower eyelid reconstruction, and compared chondromucosal grafts […]
Intracranial Subdural Empyema Mimicking Chronic Subdural Hematoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1MaMWh9 via IFTTT
Treatment Efficacy of the Transsylvian Approach Versus the Transtemporal Cortex Approach to Evacuate Basal Ganglia Hematoma Under a Microscope
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Abstract: This study aimed to evaluate the clinical efficacy of the transsylvian approach versus the transtemporal cortex approach to evacuate basal ganglia hemorrhage under a microscope. The relevant literature was collected from PubMed, Embase, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature database, and China National Knowledge Infrastructure databases. The meta-analysis was conducted by […]
Cleft Le Fort I Osteotomy: A Video Presentation
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Abstract: In this video, we present a single piece Le Fort I osteotomy with bone graft in a patient with a unilateral cleft lip and palate. Maxillary osteotomies in the cleft patient can be challenging because of the presence of scar, palatal or alveolar fistulae, compromised teeth, and vascularization of the segments. The video demonstrates […]
Acellular Dermal Graft in Secondary Cleft Lip Deficiencies: Assessment of Results With a Reproducible Quantitative Technique
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Purpose: Considering the little evidence around acellular dermal graft application in secondary lip reshaping, this study is aimed to quantitatively examine the effect of acellular dermal graft in combination with Z-plasty technique in secondary defects of cleft lip. Methods: In this clinical investigation, patients with secondary unilateral cleft lip deformity were selected. Standard photographs were […]
KLF4, KLF5, and the Therapeutic Response
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Tumor cells inherit from their normal precursors an extensive stress response machinery that is critical for survival in response to challenges including oxidative stress, wounding, and shear stress. Kruppel-like transcription factors, including KLF4 and KLF5, are rarely affected by genetic alteration during tumorigenesis, but compose key components of the stress response machinery in normal and […]
Pregnancy history and current use of contraception among women of reproductive age in Burundi, Kenya, Rwanda, Tanzania and Uganda: analysis of demographic and health survey data
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Objective To examine the relationship between pregnancy history and the use of contraception among women of reproductive age (15–49 years) in East Africa. Methods Demographic and Health Surveys data from Burundi (2010), Kenya (2008–2009), Rwanda (2010), Tanzania (2010) and Uganda (2011) were used in the analysis. Logistic regression was used to determine the effects of […]
Household survey analysis of the impact of comprehensive strategies to improve the expanded programme on immunisation at the county level in western China, 2006-2010
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Objective To evaluate interventions to improve routine vaccination coverage and caregiver knowledge in China’s remote west, where routine immunisation is relatively weak. Design Prospective pre–post (2006–2010) evaluation in project counties; retrospective comparison based on 2004 administrative data at baseline and surveyed post-intervention (2010) data in selected non-project counties. Setting Four project counties and one non-project […]
Prevalence of alcohol and drug use in injured British Columbia drivers
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Objectives Determine the prevalence of drug use in injured drivers and identify associated demographic factors and crash characteristics. Design Prospective cross-sectional study. Setting Seven trauma centres in British Columbia, Canada (2010–2012). Participants Automobile drivers who had blood obtained within 6 h of a crash. Main outcome measures We analysed blood for cannabis, alcohol and other […]
Cross-sectional survey of Good Samaritan behaviour by physicians in North Carolina
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Objective To assess the responses of physicians to providing emergency medical assistance outside of routine clinical care. We assessed the percentage who reported previous Good Samaritan behaviour, their responses to hypothetical situations, their comfort providing specific interventions and the most likely reason they would not intervene. Setting Physicians residing in North Carolina. Participants Convenience sample […]
Determinants of postnatal depression in Sudanese women at 3 months postpartum: a cross-sectional study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Objectives Maternal mental health is a neglected issue in Sudanese healthcare. The aim of this study was to explore the factors associated with postnatal depression (PND) at 3 months postpartum in a sample of Sudanese women in Khartoum state. Setting Recruitment was from two major public antenatal care (ANC) clinics in two maternity teaching hospitals […]
Study protocol for a single-blind, placebo-controlled randomised trial of Tianjiu effects in patients with intradialytic hypotension
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Introduction Intradialytic hypotension (IDH) is the most frequent complication of haemodialysis (HD) and may contribute to cardiovascular events and high mortality. The aetiology of IDH is multifactorial; therefore, it remains a challenging problem in the management of patients with HD. Since the application of Tianjiu at specific points can influence haemodynamics, we hypothesise that Tianjiu […]
Low yield of screening asylum seekers from countries with a tuberculosis incidence of
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
In low tuberculosis (TB) incidence countries foreign-born patients constitute a high percentage of the TB burden, up to 90% in Scandinavian countries [1] and 73% in the Netherlands in 2014 [2]. Several European Union (EU) countries have developed screening strategies to identify TB in migrants at an early stage and prevent transmission, but there is […]
FG-3019 anti-connective tissue growth factor monoclonal antibody: results of an open-label clinical trial in IPF
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
FG-3019 is a fully human monoclonal antibody that interferes with the action of connective tissue growth factor, a central mediator in the pathogenesis of fibrosis. This open-label phase 2 trial evaluated the safety and efficacy of two doses of FG-3019 administered by intravenous infusion every 3 weeks for 45 weeks in patients with idiopathic pulmonary […]
Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality; however, the role of inflammatory mediators in its pathobiology remains unclear. The aim of this study was to investigate the influence of gender in COPD on lipid mediator levels. Bronchoalveolar lavage fluid (BALF) and serum were obtained from healthy never-smokers, smokers and COPD patients […]
Enhanced monocyte migration to CXCR3 and CCR5 chemokines in COPD
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Chronic obstructive pulmonary disease (COPD) patients exhibit chronic inflammation, both in the lung parenchyma and the airways, which is characterised by an increased infiltration of macrophages and T-lymphocytes, particularly CD8+ cells. Both cell types can express chemokine (C-X-C motif) receptor (CXCR)3 and C-C chemokine receptor 5 and the relevant chemokines for these receptors are elevated […]
The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Maternal smoking during pregnancy increases childhood asthma risk, but health effects in children of nonsmoking mothers passively exposed to tobacco smoke during pregnancy are unclear. We examined the association of maternal passive smoking during pregnancy and wheeze in children aged ≤2 years. Individual data of 27 993 mother–child pairs from 15 European birth cohorts were […]
In-hospital mortality following lung cancer resection: nationwide administrative database
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Our aim was to determine the effect of a national strategy for quality improvement in cancer management (the «Plan Cancer») according to time period and to assess the influence of type and volume of hospital activity on in-hospital mortality (IHM) within a large national cohort of patients operated on for lung cancer. From January 2005 […]
Resting pulmonary artery pressure of 21-24 mmHg predicts abnormal exercise haemodynamics
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
A resting mean pulmonary artery pressure (mPAP) of 21–24 mmHg is above the upper limit of normal but does not reach criteria for the diagnosis of pulmonary hypertension (PH). We sought to determine whether an mPAP of 21–24 mmHg is associated with an increased risk of developing an abnormal pulmonary vascular response during exercise. Consecutive […]
Follow-up of pulmonary right-to-left shunt in hereditary haemorrhagic telangiectasia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Pulmonary arteriovenous malformations (PAVMs) are associated with severe neurological complications in hereditary haemorrhagic telangiectasia (HHT). Transthoracic contrast echocardiography (TTCE) is recommended for screening of pulmonary right-to-left shunts (RLS). Although growth of PAVMs is shown in two small studies, no studies on follow-up with TTCE exist. All HHT patients underwent a second TTCE 5 years after […]
Effectiveness and safety of meropenem/clavulanate-containing regimens in the treatment of MDR- and XDR-TB
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
No large study has ever evaluated the efficacy, safety and tolerability of meropenem/clavulanate to treat multidrug- and extensively drug-resistant tuberculosis (MDR- and XDR-TB). The aim of this observational study was to evaluate the therapeutic contribution, effectiveness, safety and tolerability profile of meropenem/clavulanate added to a background regimen when treating MDR- and XDR-TB cases. Patients treated […]
Pregnancy history and current use of contraception among women of reproductive age in Burundi, Kenya, Rwanda, Tanzania and Uganda: analysis of demographic and health survey data
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Objective To examine the relationship between pregnancy history and the use of contraception among women of reproductive age (15–49 years) in East Africa. Methods Demographic and Health Surveys data from Burundi (2010), Kenya (2008–2009), Rwanda (2010), Tanzania (2010) and Uganda (2011) were used in the analysis. Logistic regression was used to determine the effects of […]
Dry mouth, burning sensation of the mouth, and taste alterations : Transcutaneous electric nerve stimulation (TENS) on whole salivary flow rate in postmenopausal females
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα
Effect of TENS on stimulation of saliva in postmenopausal women with or without oral dryness – An interventional study via ScienceDirect Publication: Journal of Oral Biology and Craniofacial Research *Source:*Journal of Oral Biology and Craniofacial Research Author(s): Aravinda Konidena, Dheeraj Sharma, Gagan Puri, Avani Dixit, Deepa Jatti, Rajesh Gupta BackgroundDecreased estrogen levels in postmenopausal women may cause an increase in oral symptoms including dry mouth, burning sensation of the mouth, and taste alterations. Management of salivary gland hypofunction by various modal... περισσότερα »
The Airmax® internal nasal dilator
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Does the Airmax® internal nasal dilator increase peak nasal inspiratory flow (PNIF) in adolescent athletes? via International Journal of Pediatric Otorhinolaryngology Publication date: May 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 84 Author(s): Ricardo Reis Dinardi, Cláudia Ribeiro de Andrade, Hugo Cesar Martins-Costa, Cássio da Cunha Ibiapina [image: Αποτέλεσμα εικόνας για The Airmax® internal nasal dilator] ObjectivesNasal dilators are being developed for the purpose of increasing air flow in the nasal valve. The aim of this study is to evaluate the u...περισσότερα »
Balance Chiropractic Therapy for Cervical Spondylotic Radiculopathy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Balance Chiropractic Therapy for Cervical Spondylotic Radiculopathy: *Condition*: Cervical Radiculopathy *Interventions*: Device: Balance Chiropractic Therapy; Device: Traction Therapy *Sponsor*: Feng Yang ArmsAssigned Interventions Experimental: Balance Chiropractic Therapy(BCT) patients are in the sitting position and receive the Balance Chiropractic Therapy(BCT) .1)Balancing tendon-regulation;2) Balancing osteopathy;3) Balance collaterals-dredging.The patients will received BCT 1 time every other day, 20min each time. a total of 10 times in 20 days. Device: Balance Chir... περισσότερα »
Ethical Considerations When Counseling Patients With Thyroid Cancer
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Ethical Considerations When Counseling Patients With Thyroid Cancer: *To the Editor* In a recent Viewpoint, Stack and Angelos remind physicians about ethical obligations to outline risks, benefits, and alternatives of all treatment options to patients. Discussing the option of observation for papillary microcarcinoma (PMC), the authors assert that “this approach is not the standard of care in the United States,”(p957) and, if considered, should only be offered under an institutional review board–approved research protocol or if patients sign a “surveillance contract.” [image: Fir... περισσότερα »
Depression in Chronic Rhinosinusitis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Depression in Chronic Rhinosinusitis: This study examines depression-specific outcomes after medical or surgical treatment of chronic rhinosinusitis. *Importance* Depression is frequently undiagnosed in patients with chronic rhinosinusitis (CRS) and affects quality of life, productivity, and health care use. *Objective* To examine depression-specific outcomes after medical or surgical treatment of CRS. *Design, Setting, and Participants* A multi-institutional, prospective study of patients with refractory CRS treated at tertiary academic rhinology centers was performed from Ma... περισσότερα »
Nanoscale analysis reveals agonist-sensitive and heterogeneous pools of phosphatidylinositol 4-phosphate in the plasma membrane
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 29 δευτερόλεπτα
Publication date: Available online 10 March 2016 Source:Biochimica et Biophysica Acta (BBA) – Biomembranes Author(s): Akane Yoshida, Mikiko Shigekuni, Kenji Tanabe, Akikazu Fujita Phosphatidylinositol 4-phosphate [PtdIns(4)P] is the immediate precursor of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2], which is localized to the cytoplasmic leaflet of the plasma membrane and has been reported to possess multiple cell biological functions.… Continue reading Nanoscale analysis reveals agonist-sensitive and heterogeneous pools of phosphatidylinositol 4-phosphate in the plasma mem... περισσότερα »
Partial sialoadenectomy for the treatment of benign tumours in the submandibular gland
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 29 δευτερόλεπτα
The conventional treatment for benign tumours arising in the submandibular gland (SMG) has always involved whole gland excision with the tumour. In light of developments in parotid gland functional surgery, this prospective study was performed to evaluate the effectiveness and safety of partial sialoadenectomy (PS) for benign tumours in comparison with conventional total sialoadenectomy (TS).… Continue reading Partial sialoadenectomy for the treatment of benign tumours in the submandibular gland
Psychological Reports
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 29 δευτερόλεπτα
Psychological Reports, published by SAGE Publications, last updated on 2016-03-10, available at http://prx.sagepub.com from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://prx.sagepub.com/ via IFTTT
Low yield of screening asylum seekers from countries with a tuberculosis incidence of
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 29 δευτερόλεπτα
In low tuberculosis (TB) incidence countries foreign-born patients constitute a high percentage of the TB burden, up to 90% in Scandinavian countries [1] and 73% in the Netherlands in 2014 [2]. Several European Union (EU) countries have developed screening strategies to identify TB in migrants at an early stage and prevent transmission, but there is… Continue reading Low yield of screening asylum seekers from countries with a tuberculosis incidence of
Mutant p53 regulates ovarian cancer differentiation
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 29 δευτερόλεπτα
Mutations in the tumor protein p53 (TP53) are the most frequently occurring genetic events in high-grade ovarian cancers, especially the prevalence of the TP53R175H mutant allele. In this study, we investigated the impact of the TP53R175H mutant allele on epithelial ovarian cancer (EOC) in vivo. We used the Pten/KrasG12D mutant mouse strain that develops serous… Continue reading Mutant p53 regulates ovarian cancer differentiation
FG-3019 anti-connective tissue growth factor monoclonal antibody: results of an open-label clinical trial in IPF
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 29 δευτερόλεπτα
FG-3019 is a fully human monoclonal antibody that interferes with the action of connective tissue growth factor, a central mediator in the pathogenesis of fibrosis. This open-label phase 2 trial evaluated the safety and efficacy of two doses of FG-3019 administered by intravenous infusion every 3 weeks for 45 weeks in patients with idiopathic pulmonary… Continue reading FG-3019 anti-connective tissue growth factor monoclonal antibody: results of an open-label clinical trial in IPF
GSK3 regulates 1,25D-mediated differentiation
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 29 δευτερόλεπτα
1,25-dihyroxyvitamin D3 (1,25D), the biologically active form of vitamin D, is widely considered a promising therapy for acute myeloid leukemia (AML) based on its ability to drive differentiation of leukemic cells. However, clinical trials have been disappointing in part to dose-limiting hypercalcemia. Here we show how inhibiting glycogen synthase kinase-3 (GSK3) can improve the differentiation… Continue reading GSK3 regulates 1,25D-mediated differentiation
Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 29 δευτερόλεπτα
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality; however, the role of inflammatory mediators in its pathobiology remains unclear. The aim of this study was to investigate the influence of gender in COPD on lipid mediator levels. Bronchoalveolar lavage fluid (BALF) and serum were obtained from healthy never-smokers, smokers and COPD patients… Continue reading Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD
DNA sensing promotes LLC tumor growth
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 29 δευτερόλεπτα
Cytosolic DNA sensing is an important process during the innate immune response that activates the Stimulator of Interferon Genes (STING) adaptor and induce interferon type I (IFN-I). STING incites spontaneous immunity during immunogenic tumor growth and accordingly, STING agonists induce regression of therapy-resistant tumors. However DNA, STING agonists and apoptotic cells can also promote tolerogenic… Continue reading DNA sensing promotes LLC tumor growth
Hearing loss accompanied by compound heterozygotes of truncating and nontruncating mutations in LOXHD1 identified by targeted NGS analysis
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 29 δευτερόλεπτα
Clinical characteristics of a Japanese family with hearing loss accompanied by compound heterozygous mutations in: To report two novel LOXHD1 mutations, including missense mutations and the clinical features of the patients. Abstract Objective To report two novel LOXHD1 mutations, including missense mutations and the clinical features of the patients. Methods We studied a three-generation Japanese… Continue reading Hearing loss accompanied by compound heterozygotes of truncating and nontruncating mutations in LOXHD1 identified by targeted NGS analysis
Oral Fluid Intake and Adverse Outcomes After Pediatric Tonsillectomy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Oral Fluid Intake and Adverse Outcomes After Pediatric Tonsillectomy: This cohort study examines whether the quantity of oral fluid intake before discharge is associated with adverse outcomes following tonsillectomy in pediatric patients. *Importance* This study contributes novel data on the association between oral fluid intake before discharge and adverse outcomes following tonsillectomy in pediatric patients. These data contribute to evidence-based, safe, and cost-effective decision making regarding discharge. *Objective* To determine whether the quantity of oral fluid intak... περισσότερα »
Utility of Diagnostic Molecular Markers
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Utility of Diagnostic Molecular Markers: This Viewpoint discusses the personalization of care and the critical factors in accomplishing this philosophy for patients with differentiated thyroid cancers. [image: First page PDF preview]
Accuracy of Ultrasonography-Guided Fine-Needle Aspiration
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Accuracy of Ultrasonography-Guided Fine-Needle Aspiration: This study evaluates the use of ultrasonography-guided fine-needle aspiration to detect lymph node metastasis in patients with head and neck squamous cell carcinoma who completed chemoradiotherapy. *Importance* Few patients with persistent adenopathy following chemoradiotherapy (CRT) for head and neck squamous cell carcinoma harbor viable disease. Improved selectivity for surgical salvage is needed to prevent unnecessary salvage neck dissection. *Objective* To determine whether ultrasonography-guided fine-needle aspirat...περισσότερα »
Spongiiferula fulva gen. nov., sp. nov., a Bacterium of the Family Flavobacteriaceae Isolated from a Marine Sponge
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 30 δευτερόλεπτα
Abstract A Gram stain-negative, strictly aerobic, brown-pigmented, non-motile, rod-shaped, chemoheterotrophic bacterial strain-designated A6F-119T was isolated from a marine sponge (*Rhabdastrella* sp.). Phylogenetic analyses based on the 16S rRNA gene sequence revealed that the new strain represented a member of the family *Flavobacteriaceae* of the phylum *Bacteroidetes* and that it showed highest sequence similarity (93 %) to *Tenacibaculum maritimum* NBRC 15946T. The strain could be differentiated phenotypically from the recognized members of the family *Flavobacteriaceae*. The... περισσότερα »
Parent Perception of Newborn Hearing Screening
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα
Parent Perception of Newborn Hearing Screening: This cross-sectional study provides insight into parent recall of universal newborn hearing screening. *Importance* An unacceptably high number of children who do not pass universal newborn hearing screening (UNHS) are lost to follow-up. *Objectives* To provide insight into parent recall of UNHS. *Design, Setting, and Participants* In this nationally representative cross-sectional survey, 2144 US parent households were surveyed in May 2012 using the Knowledge Panel. Responses of parents whose children were born before vs after UNHS... περισσότερα »
A Laryngeal Lesion
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα
A Laryngeal Lesion: A woman in her 90s had worsening hoarseness; flexible nasolaryngoscopy revealed normal abduction and adduction of the vocal folds with a white sessile lesion starting at the right midfold on the superior and medial surfaces that crossed the midline to involve the entire left vocal fold. What is your diagnosis? [image: First page PDF preview]
Rapidly Enlarging Forehead Mass in a Young Retinoblastoma Survivor
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Rapidly Enlarging Forehead Mass in a Young Retinoblastoma Survivor: A young man with a lesion in the supraorbital region had been treated for bilateral retinoblastoma as an infant and had advanced malignant small blue cell tumor as a teenager; a surgical specimen showed multinucleated giant cells and bizarre stromal cells suggestive of treatment effect. What is your diagnosis? [image: First page PDF preview]
Correction of severe columella and tip retraction in silicone implanted Asian short noses
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Correction of severe columella and tip retraction in silicone implanted Asian short noses: Serkan SertelEmail author, Ioana Irina Venara-Vulpe and Philippe Pasche Journal of Otolaryngology - Head & Neck Surgery201645:19 DOI: 10.1186/s40463-016-0131-9© Sertel et al. 2016 Received: 8 December 2015Accepted: 24 February 2016Published: 10 March 2016 Abstract Background Silicone Implants and other alloplastic materials are frequently used in rhinoplasty to augment Asian short noses. However, nasal deformities as a result of implant-related infections are increasing in incidence... περισσότερα »
How can the audiogram be more useful?
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
How can the audiogram be more useful?: The Canadian Hearing and Auditory Research Translation (CHART) group Robert V HarrisonEmail author Journal of Otolaryngology - Head & Neck Surgery201645:18 DOI: 10.1186/s40463-016-0132-8© Harrison. 2016 Received: 27 November 2015Accepted: 4 March 2016Published: 10 March 2016 Abstract The Canadian Hearing and Auditory Research Translation (CHART) group is a newly formed taskforce to develop collaborative research initiatives. Initial discussions centered on diagnostic improvements for middle ear disease, auditory neuropathy spectrum di... περισσότερα »
Hearing loss accompanied by compound heterozygotes of truncating and nontruncating mutations in LOXHD1 identified by targeted NGS analysis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
Clinical characteristics of a Japanese family with hearing loss accompanied by compound heterozygous mutations in: To report two novel LOXHD1 mutations, including missense mutations and the clinical features of the patients. AbstractObjective To report two novel *LOXHD1* mutations, including missense mutations and the clinical features of the patients. Methods We studied a three-generation Japanese family with hearing loss. Targeted next-generation sequencing was used for genetic analysis. Conditional orientation response audiometry and pure tone audiometry were used to assess he... περισσότερα »
Cec de Rinofaringe
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
Cec de Rinofaringe: Cec de Rinofaringe
Hemilaringite infecciosa
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
Hemilaringite infecciosa: Hemilaringite infecciosa
Meningioma goteira olfatória
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
Meningioma goteira olfatória: Meningioma goteira olfatória
Radical Espontânea
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
Radical Espontânea: Radical espontânea
Soltura de prótese de estapedo
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
Soltura de prótese de estapedo. Dr Mitre: Soltura de prótese de estapedo. Dr Mitre
HNCs : Improving Quality of Life With Nabilone During Radiotherapy Treatments
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial: Objectives: Patients treated for head and neck carcinomas experience a significant deterioration of their quality of life during treatments because of severe side effects. Nabilone has many properties that could alleviate symptoms caused by radiotherapy and improve patients’ quality of life. The aim of the present study was to compare the effects of nabilone versus placebo on the quality of life and side effects during radiotherapy for... περισσότερα »
Treatment and Survival Trends in Glottic Carcinoma in Situ and Stage I Cancer
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Treatment and Survival Trends in Glottic Carcinoma in Situ and Stage I Cancer From 1988 to 2012: Objective: To identify trends in treatment and survival for patients with stage I glottic cancer and glottic carcinoma in situ (CIS). Methods: The 18-registry SEER data were analyzed for CIS and stage I glottic cancer. Treatment variables and observed and relative survival were assessed separately for stage I and glottic CIS. Results: Among 14 025 cases of stage I glottic cancer identified from 1988 to 2012, radiation was the most common treatment for all eras. An increase in surgical... περισσότερα »
Nasal and Tracheal Microbial Colonization in Laryngectomized Patients
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Nasal and Tracheal Microbial Colonization in Laryngectomized Patients: Objective: Complete separation of upper and lower respiratory tract after total laryngectomy results in loss of physiological nasal functions and presence of "unconditioned" inspired air in lower airways. Aim of this study is evaluating the presence of a microbial colonization of nasal cavities and trachea in laryngectomized long-term survivors. Methods: Twenty-five laryngectomized patients underwent symptoms’ anamnestic evaluation, endoscopic fiber optic nasal and tracheal examination, specimen collection for ... περισσότερα »
Suppression of Tinnitus in Chinese Patients Receiving Regular Cochlear Implant Programming
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Suppression of Tinnitus in Chinese Patients Receiving Regular Cochlear Implant Programming: Objective: To assess the clinical effect of cochlear implant programming on tinnitus. Methods: Tinnitus patients (n = 234) were divided into 3 groups: (1) preoperative tinnitus (n = 108), (2) postoperative tinnitus occurring before implant switch-on at week 4 (n = 88), and (3) tinnitus occurring more than 1 year postoperatively (n = 44). Patients in each group were randomly allocated into a programming subgroup that received programming for 12 weeks postoperatively or after tinnitus occurren... περισσότερα »
Elongated Uvula Causing Chronic Cough: Role of the Modified Uvulopalatoplasty Procedure
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Elongated Uvula Causing Chronic Cough: Role of the Modified Uvulopalatoplasty Procedure: Objective: A subset of patients previously diagnosed with idiopathic chronic cough were found to have an elongated uvula contacting the laryngeal surface of the epiglottis and inducing a cough reflex. These patients were successfully treated with an in-office modified uvulopalatoplasty procedure (mUPP) at our institution. We aim to further categorize this subset of patients and describe the mUPP that can potentially offer this group of patients cure for their chronic cough. Study Design: Insti... περισσότερα »
Speech Recognition in Noise by Younger and Older Adults: Effects of Age, Hearing Loss, and Temporal Resolution
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Speech Recognition in Noise by Younger and Older Adults: Effects of Age, Hearing Loss, and Temporal Resolution: Objectives: Purpose of the present study is to evaluate the effects of aging on temporal resolution and speech understanding in noise. Methods: Twenty-seven young and 33 older normal hearing adults participated in this study. Temporal resolution was investigated using the Gaps in Noise (GIN) test. Understanding sentences in noise was investigated using a Dutch sentences (LIST) test. Results: Results demonstrated that older adults have significantly worse temporal resolu...περισσότερα »
Mast Cell Deficiency Limits the Development of Chronic Rhinosinusitis in Mice
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Mast Cell Deficiency Limits the Development of Chronic Rhinosinusitis in Mice: Background: Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in adults in both developing and developed countries. The etiology and pathogenesis of CRS remain poorly understood, and the disease is refractory to therapy in many patients. Mast cell activation has been demonstrated in the sinonasal mucosa of patients with CRS; however, the specific contribution of mast cells to the development and pathogenesis of this disease has not been established. Objective: The objective of this...περισσότερα »
Prognostic Relevance of Mucosal Waves in Patients With Unilateral Vocal Fold Paralysis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Prognostic Relevance of Mucosal Waves in Patients With Unilateral Vocal Fold Paralysis: Objectives: To analyze the prognostic relevance of mucosal waves (MWs) for recovery of unilateral vocal fold paralysis (UVP). Methods: The charts and stroboscopic examinations of 100 consecutive patients with a complete UVP were reviewed retrospectively. All had a minimal (estimated <3 mm) mucosal gap on stroboscopy. A positive or negative MW on the paralyzed vocal fold was associated with complete recovery to full adduction and abduction. All patients were followed for at least 12 months. Resu...περισσότερα »
IL-1 Receptor Antagonist Inhibits Early Granulation Formation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
IL-1 Receptor Antagonist Inhibits Early Granulation Formation: Purpose: Using a functional model of airway granulation tissue in laryngotracheal stenosis, we investigated changes in histopathology and inflammatory markers within granulation tissue in response to an interleukin-1 receptor antagonist (IL-1Ra). This study allows us to further delineate the immune response to wound healing and potentially identify treatment markers. Methods: Laryngotracheal complexes (LTCs) of donor mice underwent direct airway injury. The LTCs were transplanted into subcutaneous tissue of recipient mi... περισσότερα »
Diagnosis of Pediatric Foreign Body Ingestion: Clinical Presentation, Physical Examination, and Radiologic Findings
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Diagnosis of Pediatric Foreign Body Ingestion: Clinical Presentation, Physical Examination, and Radiologic Findings: Objectives: (1) To describe clinical and radiologic findings in patients with esophageal foreign bodies. (2) To examine the sensitivity and specificity of history, physical examination, and radiologic studies in children with suspected foreign body ingestion. Methods: A retrospective cohort study was performed evaluating all children who underwent esophagoscopy for suspected foreign body ingestion at our institution from 2006 to 2013. Results: Five hundred forty-th... περισσότερα »
A Single Primary Site Obstruction May Lead to Sleep-Disordered Breathing in Multiple Sites: An Animal Model
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
A Single Primary Site Obstruction May Lead to Sleep-Disordered Breathing in Multiple Sites: An Animal Model: Objectives: This study aimed to investigate the dynamic upper airway changes occurring in an obstructive sleep apnea (OSA) rabbit model using dynamic computerized tomography (CT). Methods: In this study, 2.5 U of botulinum toxin type A was injected into the genioglossus to paralyze the tongue in the OSA group (n = 7). The control group was injected with normal saline (n = 7). Apnea-hypopnea index was measured using ApneaLink at baseline and at 1, 2, 3, 4, 6, and 8 weeks pos...περισσότερα »
Office-Based Subglottic Evaluation in Children With Risk of Subglottic Hemangioma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Office-Based Subglottic Evaluation in Children With Risk of Subglottic Hemangioma: Purpose: Children with V3 cutaneous infantile hemangiomas (IH) and PHACE syndrome have a high incidence for airway hemangioma, 29% and 52%, respectively. Therefore, a clinical evaluation for these high-risk children is essential. We report our experience with in-office lower airway evaluation (OLAE) in these high-risk children. Results: Since 2003, 5 children with IH of the V3 cutaneous distribution and 3 children with PHACE syndrome underwent OLAE. Average age of presentation was 2.75 months. Two c...περισσότερα »
Cross-sectional survey of Good Samaritan behaviour by physicians in North Carolina
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Objective To assess the responses of physicians to providing emergency medical assistance outside of routine clinical care. We assessed the percentage who reported previous Good Samaritan behaviour, their responses to hypothetical situations, their comfort providing specific interventions and the most likely reason they would not intervene. Setting Physicians residing in North Carolina. Participants Convenience sample […]
Determinants of postnatal depression in Sudanese women at 3 months postpartum: a cross-sectional study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Objectives Maternal mental health is a neglected issue in Sudanese healthcare. The aim of this study was to explore the factors associated with postnatal depression (PND) at 3 months postpartum in a sample of Sudanese women in Khartoum state. Setting Recruitment was from two major public antenatal care (ANC) clinics in two maternity teaching hospitals […]
Study protocol for a single-blind, placebo-controlled randomised trial of Tianjiu effects in patients with intradialytic hypotension
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Introduction Intradialytic hypotension (IDH) is the most frequent complication of haemodialysis (HD) and may contribute to cardiovascular events and high mortality. The aetiology of IDH is multifactorial; therefore, it remains a challenging problem in the management of patients with HD. Since the application of Tianjiu at specific points can influence haemodynamics, we hypothesise that Tianjiu […]
What factors are important for deprescribing in Australian long-term care facilities? Perspectives of residents and health professionals
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Objectives Polypharmacy and multimorbidity are common in long-term care facilities (LTCFs). Reducing polypharmacy may reduce adverse events and maintain quality of life. Deprescribing refers to reducing medications after consideration of therapeutic goals, benefits and risks, and medical ethics. The objective was to use nominal group technique (NGT) to generate then rank factors that general medical […]
Past speculations of the future: a review of the methods used for forecasting emerging health technologies
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Objectives Forecasting can support rational decision-making around the introduction and use of emerging health technologies and prevent investment in technologies that have limited long-term potential. However, forecasting methods need to be credible. We performed a systematic search to identify the methods used in forecasting studies to predict future health technologies within a 3–20-year timeframe. Identification […]
Health service utilisation for anogenital warts in Ontario, Canada prior to the human papillomavirus (HPV) vaccine programme introduction: a retrospective longitudinal population-based study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Objective Trends in occurrence of anogenital warts (AGWs) can provide early evidence of human papillomavirus (HPV) vaccination programme impact on preventing HPV infection and HPV-induced lesions. The objective of this study was to provide a baseline of AGW epidemiology in Ontario prior to the introduction of the publicly-funded school-based HPV vaccination programme in September 2007. […]
Does family-centred neonatal discharge planning reduce healthcare usage? A before and after study in South West England
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Objective To implement parent-oriented discharge planning (Train-to-Home) for preterm infants in neonatal care. Design Before and after study, investigating the effects of the intervention during two 11-month periods before and after implementation. Setting Four local neonatal units (LNUs) in South West England. Participants Infants without major anomalies born at 27–33 weeks’ gestation admitted to participating […]
Giving thanks – Addressing the worldwide plastic surgeon shortage
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Today it is Thanksgiving, a national holiday here in America. Almost 500 hundred years ago, the Pilgrims sat down with their Native American neighbours to celebrate the harvest. Now Thanksgiving has multiple memes having morphed into a day for watching parades and American football on television, feasting on turkey with friends and family and preparing […]
GENETICS IN ENDOCRINOLOGY: Gain and loss of function mutations of the calcium-sensing receptor and associated proteins: current treatment concepts
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
The calcium-sensing receptor (CASR) is the main calcium sensor in the maintenance of calcium metabolism. Mutations of the CASR, the G protein alpha 11 (GNA11) and the adaptor-related protein complex 2 sigma 1 subunit (AP2S1) genes can shift the set point for calcium sensing causing hyper- or hypo-calcemic disorders. Therapeutic concepts for these rare diseases […]
MECHANISMS IN ENDOCRINOLOGY: Metabolic and inflammatory pathways on the pathogenesis of type 2 diabetes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Obesity is the main risk factor for type 2 diabetes (T2D). Studies performed over the last 20 years have identified inflammation as the most important link between these two diseases. During the development of obesity, there is activation of subclinical inflammatory activity in tissues involved in metabolism and energy homeostasis. Intracellular serine/threonine kinases activated in […]
Determining clinical practice of expert physiotherapy for patients undergoing lumbar spinal fusion: a cross-sectional survey study
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Abstract Purpose To determine the content of current Dutch expert hospital physiotherapy practice for patients undergoing lumbar spinal fusion (LSF), to gain insight into expert-based clinical practice. Methods At each hospital where LSF is performed, one expert physiotherapist received an e-mailed questionnaire, about pre- and postoperative physiotherapy and discharge after LSF. The level of uniformity in goals and interventions was graded on a scale from no uniformity (50–60 %) to very strong uniformity (91–100 %). Results LSF was performed at 34 of the 67 contacted hospitals.... περισσότερα »
Relationship between cervical sagittal alignment and health-related quality of life in adolescent idiopathic scoliosis
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Abstract Purpose Little information is available on the relationship between cervical sagittal alignment and health-related quality of life (HRQOL) in adolescent idiopathic scoliosis (AIS) patients. The aim of this study was to identify relationships between postoperative cervical sagittal alignment and HRQOL in AIS. Methods The study and control groups comprised 67 AIS patients (51 girls and 16 boys). All underwent anteroposterior and lateral plain radiography and completed clinical questionnaires. The radiographic parameters investigated were pre- and postoperative C2–C7 lordos... περισσότερα »
Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 1 ώρα
Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some […]
Quantitative Detection of PEGylated Biomacromolecules in Biological Fluids by NMR
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b04565 [image: ancham?d=yIl2AUoC8zA] from #Medicine via ola Kala on Inoreader http://ift.tt/1SEeuSC via IFTTT
Improved Steroids Detection and Evidence for Their Regiospecific Decompositions Using Anion Attachment Mass Spectrometry
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
[image: TOC Graphic] Analytical Chemistry DOI: 10.1021/acs.analchem.5b04097 [image: ancham?d=yIl2AUoC8zA] from #Medicine via ola Kala on Inoreader http://ift.tt/1SEerGx via IFTTT
Recovery of motor imagery ability in the first year after stroke.
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
The aim of this study was to examine the level and recovery of motor imagery ability (MIA) in the first year after stroke and whether the recovery of MIA is related to that of arm/hand function. Twenty-three patients with diminished arm/hand function were included. The accuracy score on the hand laterality judgment task was used to assess MIA and the Fugl-Meyer Assessment was used to evaluate the recovery of arm/hand function. The patients were assessed 3, 6, 16, 26, and 52 weeks after stroke. In the first year after stroke, the percentage of patients with moderate to good MIA impro... περισσότερα »
Distal Radius Fractures Concepts - Everything You Need To Know - Dr. Nabil Ebraheim
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Educational video describing injuries associated with the distal radius. Become a friend on facebook: http://ift.tt/1eMj35K Follow me on twitter: https://twitter.com/#!/DrEbraheim_UTMC Donate to the University of Toledo Foundation Department of Orthopaedic Surgery Endowed Chair Fund: http://ift.tt/1HCFAla from #Medicine via ola Kala on Inoreader https://www.youtube.com/watch?v=Xfuq5b7QNRY via IFTTT
Once-Monthly Continuous Erythropoietin Receptor Activator (C.E.R.A.) in Patients with Hemodialysis-Dependent Chronic Kidney Disease: Pooled Data from Phase III Trials
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Introduction Erythropoiesis-stimulating agents and iron are commonly used in patients with chronic kidney disease with the aim of correcting anemia and maintaining stable hemoglobin levels. We analyzed pooled data from 13 studies with similar designs included in the Umbrella Continuous Erythropoietin Receptor Activator (C.E.R.A.) program to investigate the effects of continuous erythropoiesis receptor activator in clinically relevant subgroups of patients with chronic kidney disease and to determine whether the efficacy and safety outcomes demonstrated in the overall chro... περισσότερα »
Bimatoprost in pediatric subjects
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Borchert M, Bruce S, Wirta D, Yoelin SG, Lee S, Mao C, VanDenburgh A from #Medicine via ola Kala on Inoreader http://ift.tt/1Lfp0OT via IFTTT
Psychological factors are related to pain intensity in back-healthy people who develop clinically relevant pain during prolonged standing: A preliminary study
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
An induced-pain paradigm has been used to examine risk factors for LBP development during prolonged standing in back-healthy people (standing paradigm). Prior studies using induced-pain methods suggest that pain intensity may be related to psychological factors. It is not currently known, however, if pain intensity reported during the standing paradigm is related to psychological factors. from #Medicine via ola Kala on Inoreader http://ift.tt/1MaaDpT via IFTTT
Unusual Electromyographic Findings Associated with Colchicine Neuromyopathy: A Case Report
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
An 83-year-old male with multiple medical problems including gout, pseudogout, and renal insufficiency presented with more than a year of proximal weakness. He had an extensive prior medical workup including a normal creatinine kinase (CK). His weakness persisted despite endurance and strength training. Electrodiagnostic findings were consistent with a myopathy, though without abnormal spontaneous activity, and a length-dependent neuropathy. Based on these findings, colchicine was discontinued. The patient experienced marked symptomatic improvement within a week. from #Medicine v... περισσότερα »
Test-retest reliability and convergent validity of three manual dexterity measures in persons with chronic stroke
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Reduced manual dexterity is common in persons after stroke. Different measures are used to assess manual dexterity but there is a lack of knowledge about their reliability and how they are related. from #Medicine via ola Kala on Inoreader http://ift.tt/1QKPKab via IFTTT
Case Report: Thoracic Outlet Syndrome causing phantom hand pain in a person with a transradial amputation
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
In this case, a 47-year old commercial truck driver with a remote right transradial amputation presented with pain in the medial aspect of his right phantom hand. He was diagnosed with thoracic outlet syndrome (TOS). This was attributed to the muscular demands associated with using his body-powered prosthesis for many years. TOS remains a controversial diagnosis in the able-bodied population and a unique diagnostic challenge in a patient with a transradial amputation. In this case, consideration of TOS guided the rehabilitation and treatment plan. from #Medicine via ola Kala on In... περισσότερα »
Effects of balance control through trunk movement during square and semicircular turns on gait velocity, center of mass acceleration, and energy expenditure in older adults
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Turning during ambulation is a common movement in everyday life, but complex and challenging for older adults. Balance control through trunk movement provides a stable platform during walking, thus it is an essential component of safe and efficient turning during walking in elderly individuals. from #Medicine via ola Kala on Inoreader http://ift.tt/1MaaDpN via IFTTT
High-Pressure Balloon-Assisted Stretching of the Coracohumeral Ligament to Determine the Optimal Stretching Positions: a Cadaveric Study
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
The coracohumeral ligament (CHL) is a thick capsular structure and markedly thickened when affected by adhesive capsulitis. Therapeutic stretching is the most commonly applied treatment for adhesive capsulitis, but optimal stretching postures for maximal therapeutic effects on the CHL have not been fully investigated. from #Medicine via ola Kala on Inoreader http://ift.tt/1QKPJTH via IFTTT
Influence of Relative Age on Diagnosis and Treatment of Attention-Deficit Hyperactivity Disorder in Taiwanese Children
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 10 March 2016 Source:The Journal of Pediatrics Author(s): Mu-Hong Chen, Wen-Hsuan Lan, Ya-Mei Bai, Kai-Lin Huang, Tung-Ping Su, Shih-Jen Tsai, Cheng-Ta Li, Wei-Chen Lin, Wen-Han Chang, Tai-Long Pan, Tzeng-Ji Chen, Ju-Wei Hsu ObjectiveTo determine the potential influence of relative age on the diagnosis and treatment of attention-deficit hyperactivity disorder (ADHD), especially […]
Moderate-to-Vigorous Physical Activity, Indices of Cognitive Control, and Academic Achievement in Preadolescents
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 10 March 2016 Source:The Journal of Pediatrics Author(s): Dominika M. Pindus, Eric S. Drollette, Mark R. Scudder, Naiman A. Khan, Lauren B. Raine, Lauren B. Sherar, Dale W. Esliger, Arthur F. Kramer, Charles H. Hillman ObjectiveTo assess whether preadolescents’ objectively measured moderate-to-vigorous physical activity (MVPA) is associated with cognitive control and […]
Alexander of Tralles and the first portrayal of a placebo by illusion in the 6th century AD
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/227tgE6 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Prospective, single-center cohort study analyzing the efficacy of complete laparoscopic resection on recurrent hepatocellular carcinoma.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
CONCLUSIONS: For the patients who previously underwent conventional open surgical resection of HCC, complete laparoscopic resection was safe and effective for recurrent HCC and resulted in a shorter operation time, less intraoperative blood loss, and a faster postoperative recovery than conventional open surgery. Laparoscopic resection was especially advantageous for the patients with contralateral HCC recurrence. […]
A specific aptamer-cell penetrating peptides complex delivered siRNA efficiently and suppressed prostate tumor growth in vivo.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Authors: Diao Y, Liu J, Ma Y, Su M, Zhang H, Hao X Abstract Specific and efficient delivery of siRNA into intended tumor cells remains as a challenge, even though RNAi has been exploited as a new strategy for prostate cancer therapy. This work aims to address both specificity and efficiency of SURVIVIN-siRNA delivery by […]
PD-1/PD-L1 expression in non-small-cell lung cancer and its correlation with EGFR/KRAS mutations.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This study was aimed to detect the correlation among EGFR/KRAS status and PD-1/PD-L1 expression in non-small-cell lung cancer (NSCLC) patients. PD-1 and PD-L1 expressions were detected by immunohistochemistry in 100 surgically resected lung adenocarcinoma tissues and were statistically correlated with clinicopathological characteristics including EGFR and KRAS statuses. Besides, the overall survival (OS) times were analyzed. […]
