Laryngeal ultrasound and vocal fold movement in the pediatric cardiovascular intensive care unit
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
Laryngeal ultrasound and vocal fold movement in the pediatric cardiovascular intensive care unit: Objectives/Hypothesis Vocal fold motion impairment (VFMI) is a known sequela of cardiovascular surgery. The gold standard for the evaluation of vocal fold movement is flexible nasolaryngoscopy (FNL). Although safe, FNL does cause measurable physiologic changes. Noxious stimuli in cardiovascular intensive care unit (CVICU) neonates may cause imbalance between the pulmonary and systemic circulations and potentially circulatory collapse. The goals of this project were to determine the acc...περισσότερα »
Recruitment of underserved, high-risk participants to a head and neck cancer screening program
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
Recruitment of underserved, high-risk participants to a head and neck cancer screening program: [image: cover.gif?v=1&s=70d968db1aa799c81f57954d] Objectives/Hypothesis Early detection is essential in head and neck cancer treatment as prognosis varies greatly with stage at diagnosis. Underserved populations often present with advanced disease, and individuals with tobacco and heavy alcohol use demonstrate a higher head and neck cancer incidence. This study aims to evaluate whether various promotional methods differentially recruited behavioral risk factor positive and/or underser... περισσότερα »
Tonsillectomy in adults with obstructive sleep apnea
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
Tonsillectomy in adults with obstructive sleep apnea: [image: cover.gif?v=1&s=70d968db1aa799c81f57954d] Objectives/Hypothesis To study whether tonsillectomy is effective on obstructive sleep apnea (OSA) in adults with large tonsils. Study Design A multicenter prospective interventional study. Methods The study comprised 28 patients with OSA, an apnea–hypopnea index of > 10, large tonsils (Friedman tonsil size 3 and 4), and age 18 to 59 years. They were derived from 41 consecutive males and females with large tonsils referred for a suspicion of sleep apnea to the ear, nose, and thr...περισσότερα »
Effect of the tracheoesophageal voice resistance test in total laryngectomees
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
Effect of the tracheoesophageal voice resistance test in total laryngectomees: [image: cover.gif?v=1&s=70d968db1aa799c81f57954d] Objectives/Hypothesis To analyze tracheoesophageal voice resistance in laryngectomized patients by comparing the acoustic, perceptive-auditory and self-evaluation measures before and after the voice resistance test. Study Design An observational, experimental study with a quantitative and descriptive approach. Methods Nineteen total laryngectomees were submitted for capture of vocal intensity, self-assessment of signs and symptoms of voice fatigue using... περισσότερα »
Phonosurgical resection using submucosal infusion technique for precancerous laryngeal leukoplakia
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
Phonosurgical resection using submucosal infusion technique for precancerous laryngeal leukoplakia: [image: cover.gif?v=1&s=70d968db1aa799c81f57954d] Objectives/Hypothesis This study was designed to assess the feasibility of the submucosal infusion technique combined with microflap dissection as a radical therapeutic and diagnostic option for precancerous laryngeal leukoplakia. Study Design Retrospective study. Methods Severe dysplasia or carcinoma in situ was diagnosed after phonomicrosurgical dissections in 25 patients with unilateral laryngeal leukoplakia. Of these, 15 patient... περισσότερα »
Office-based narrow-band imaging–guided flexible laryngoscopic tissue samplings
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
Reliability of Objectives/Hypothesis Direct suspension laryngoscopic biopsy performed under general anesthesia is the conventional management for obtaining pathological diagnosis for neoplasms of the larynx, oropharynx, and hypopharynx. Since the development of distal chip laryngoscopy and digital imaging systems, transnasal flexible laryngoscopy tissue sampling has gained popularity as an office-based procedure. Additional assessment with narrow-band imaging (NBI) can help to increase the diagnostic yield. The aim of the study was to evaluate the accuracy, sensitivity, and spe... περισσότερα »
Prolonged allergen exposure is associated with increased thymic stromal lymphopoietin expression and Th2-skewing
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
in mouse models of chronic rhinosinusitis: [image: cover.gif?v=1&s=70d968db1aa799c81f57954d] Objectives/Hypothesis Chronic rhinosinusitis (CRS) is characterized by a dysfunctional host-environment interaction at the nasal mucosa. Contributions of host susceptibility factors such as atopy and aspirin sensitivity to CRS pathophysiology are well established. However, clinical studies on the effects of environmental factors are limited. This study investigates the histological and immunological effects of allergen exposure duration in animal models. Study Design Animal study. Metho...περισσότερα »
Can Iron Treatments Aggravate Epistaxis in Some Patients With Hereditary Hemorrhagic Telangiectasia?
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
Can Iron Treatments Aggravate Epistaxis in Some Patients With Hereditary Hemorrhagic Telangiectasia?: [image: cover.gif?v=1&s=70d968db1aa799c81f57954d] Objectives/Hypothesis To examine whether there is a rationale for iron treatments precipitating nosebleeds (epistaxis) in a subgroup of patients with hereditary hemorrhagic telangiectasia (HHT). Study Design Survey evaluation of HHT patients, and a randomized control trial in healthy volunteers. Methods Nosebleed severity in response to iron treatments and standard investigations were evaluated by unbiased surveys in patients with...περισσότερα »
Surgical salvage of recurrent vestibular schwannoma following prior stereotactic radiosurgery
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
Surgical salvage of recurrent vestibular schwannoma following prior stereotactic radiosurgery: [image: cover.gif?v=1&s=70d968db1aa799c81f57954d] Objectives/Hypothesis To evaluate outcomes of salvage surgery for vestibular schwannoma (VS) that failed primary stereotactic radiosurgery (SRS). Methods Case-control study of 37 patients who underwent surgical resection of sporadic VS following prior SRS at two tertiary academic referral centers between 2003 and 2015. A cohort of nonirradiated control subjects, matched according to tumor size, age, and treatment center, were used as com... περισσότερα »
Phonomicrosurgery simulation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
A low-cost teaching model using easily accessible materials: [image: cover.gif?v=1&s=70d968db1aa799c81f57954d] Objectives/Hypothesis To introduce the use of a new phonomicrosurgical trainer using easily accessible materials, and to establish the effectiveness of the model. Study Design The model uses a grape imbedded in gelatin, a microscope, and microlaryngeal instruments. The study was designed to test baseline differences in training levels, as well as improvement in performance after training with the simulation model. Methods Thirty subjects enrolled in the Stanford Universit... περισσότερα »
Epitympanum volume and tympanic isthmus area in temporal bones with retraction pockets
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
Epitympanum volume and tympanic isthmus area in temporal bones with retraction pockets: [image: cover.gif?v=1&s=70d968db1aa799c81f57954d] Objectives/Hypothesis To compare the volume of the epitympanic space, as well as the area of the tympanic isthmus, in human temporal bones with retraction pockets to those with chronic otitis media without retraction pockets and to those with neither condition. Study Design Comparative human temporal bone study. Methods We generated a three-dimensional model of the bony epitympanum and measured the epitympanic space. We also compared the area o...περισσότερα »
Labial minor salivary gland biopsy for the diagnosis of Sjögren's syndrome
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
A validated method of [image: cover.gif?v=1&s=70d968db1aa799c81f57954d] Objectives/Hypothesis To validate a technique and outcomes of labial minor salivary gland biopsy (LSGB) used for the diagnosis of Sjögren's syndrome (SS). Study Design Prospective cohort study. Methods Clinical data were prospectively obtained pre- and postbiopsy using patient-reported questionnaires. LSGB was performed using described methods. Specimens were analyzed by a pathologist with expertise in SS and assessed using established criteria to determine the focus score. Data were analyzed using cross-tabu... περισσότερα »
Commentary: What? A Resident as an Expert Witness?
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
The American legal system is adversarial. (1) It is a contest in which two or more parties assume opposing viewpoints. Accusations and demands are made, evidence developed and presented, and arguments made. All this proceeds according to statutory rules or common law. Finally, the “Trier of Fact,” typically a jury or judge, assesses the facts and arguments in play and renders a decision as guided, again, by a set of rules that have been developed and refined over decades and even centuries of law. This article is protected by copyright. All rights reserved. from Emergency Medicin... περισσότερα »
Necrosis of the modiolus
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Discharging mastoid cavity caused by necrosis of the modiolus via Acta Otorrinolaringologica English [image: Image for figure Figure 1] [image: Image for figure Figure 2] [image: Image for figure Figure 3] *Source:*Acta Otorrinolaringologica (English Edition), Volume 67, Issue 2 Author(s): João Pimentel, Pedro Escada
Laryngeal Metastases of Acral Lentiginous Melanoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
: Narrow Band Imaging via Acta Otorrinolaringologica English [image: Image for figure Figure 1] [image: Image for figure Figure 2] *Source:*Acta Otorrinolaringologica (English Edition), Volume 67, Issue 2 Author(s): Eulalia Porras Alonso, Blydy Noemith Añaguary Torres, Miguel Alberto Rodríguez Pérez
Mantle Cell Lymphoma in the Subgaleal Layer of the Scalp
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Secondary Presentation of via Acta Otorrinolaringologica English [image: TC axial section: asymmetry in the right occipital musculature.] [image: FISH: we observe translocation in chromosome 11 of the Bcl-1 gene using specific ...] *Source:*Acta Otorrinolaringologica (English Edition), Volume 67, Issue 2 Author(s): Montserrat Borràs Perera, Javier Galindo Ortego, Eduard Bodet Agustí, Jordi Tarragona Foradada
Determining the Safety and Efficacy of Gluteal Augmentation
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 25 δευτερόλεπτα
A new study examines two options for augmentation gluteoplasty -- silicone implants and autologous fat grafting. How do they compare in terms of complication outcomes? *Plastic and Reconstructive Surgery* from #ENT via xlomafota13 on Inoreader http://ift.tt/1T8g5MA via IFTTT
Disentangling Tfr cells from Treg cells and Tfh cells: How to untie the Gordian knot
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 25 δευτερόλεπτα
T follicular regulatory (Tfr) cells are a subpopulation of Treg cells that have adopted the T follicular helper cell program to localize to the B-cell follicle. Because of the difficulties in generating mouse models in which Tfr cells are selectively affected, determining where and how Tfr cells regulate the germinal center response remains to be resolved. In this issue of the *European Journal of Immunology*, Dent and colleagues [Eur. J. Immunol. 2016. 46: XXXX–XXXX] describe a simple, elegant mouse model to conditionally delete Tfr cells without impacting on the Treg- and Tfh-ce... περισσότερα »
Intravascular clearance of disseminating Cryptococcus neoformans in the brain can be improved by enhancing neutrophil recruitment in mice
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 26 δευτερόλεπτα
Extrapulmonary dissemination of *Cryptococcus neoformans* (*C. neoformans*) is one of the most critical steps in the development of meningoencephalitis. Here, we report that clearance of the disseminating *C. neoformans* occurs within the brain microvasculature. Interestingly, the efficiency of the intravascular clearance in the brain is reduced compared to that in the lung. Intravascular clearance is mainly mediated by neutrophils, and complement C5a receptor signaling is crucial for mediating neutrophil recruitment in the vasculature. *C. neoformans*-stimulated actin polymeriza... περισσότερα »
Interaction of the LILRB1 inhibitory receptor with HLA class Ia dimers
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 26 δευτερόλεπτα
Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) has been reported to interact with a wide spectrum of HLA class I (HLA-I) molecules, albeit with different affinities determined by allelic polymorphisms and conformational features. HLA-G dimerization and the presence of intracellular Cys residues in HLA-B7 have been shown to be critical for their recognition by LILRB1. We hypothesized that dimerization of classical HLA class Ia molecules, previously detected in exosomes, might enhance their interaction with LILRB1. A soluble LILRB1-Fc fusion protein and a sens... περισσότερα »
Naso-Oropharyngeal Choristoma (Hairy Polyps)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
in Adults: A New Case, and Review of the Literature via Acta Otorrinolaringologica English [image: A large fleshy mass could be seen in the oropharynx of this 42-year-old woman. ...] [image: Histopathology showed mature tissue elements of ectodermal and mesodermal ...] *Source:*Acta Otorrinolaringologica (English Edition), Volume 67, Issue 2 Author(s): Mainak Dutta, Soumya Ghatak, Soham Roy, Ramanuj Sinha
Chondroid Hamartoma of the Larynx
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
: An Exceptional Case via Acta Otorrinolaringologica English [image: Neck and chest CT images of right paretic vocal fold, non-specific bilateral ...] [image: Macroscopic and microscopic images of the surgical piece of the ventricular ...] *Source:*Acta Otorrinolaringologica (English Edition), Volume 67, Issue 2 Author(s): Eduardo García Rica, Juan Manuel Maza Solano, Tomás Herrero Salado, Serafín Sánchez Gómez
Cochlear Implant : Pneumolabyrinth
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
: An Atypical Complication in a Cochlear Implant via Acta Otorrinolaringologica English [image: Occupation by air at middle, inner and right mastoid level. Electrode guide ...] [image: (A) Swelling of the external mastoid wall from pressurized air. (B) Opening of ...] [image: Disappearance of the air in the inner ear structures and mastoid attachment.] *Source:*Acta Otorrinolaringologica (English Edition), Volume 67, Issue 2 Author(s): M. del Prado Venegas, Julia de Juan, César Orús, Manuel de Juan
Odontogenic Sinusitis, Oro-antral Fistula and Surgical Repair by Bichat's Fat Pad
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
: Literature Review via Acta Otorrinolaringologica English Publication date: March–April 2016 *Source:*Acta Otorrinolaringologica (English Edition), Volume 67, Issue 2 Author(s): Gustavo Bravo Cordero, Simona Minzer Ferrer, Lara Fernández Odontogenic sinusitis accounts for 10%–12% of maxillary sinusitis. It occurs due to an interruption of the mucoperiosteum in response to a series of conditions, most frequently the extraction of a superior tooth. Its treatment has two bases: treating the infection and managing the oroantral fistula that perpetuates the infection. Communications smaller... περισσότερα »
Sudden Hearing Loss
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
: National Survey in Spain via Acta Otorrinolaringologica English Publication date: March–April 2016 *Source:*Acta Otorrinolaringologica (English Edition), Volume 67, Issue 2 Author(s): Elizabeth Amarillo, Estefanía Hernández-García, Mayte Herrera, José Ramón García Berrocal, Ana García Arumí, Enrique Durio, Guillermo Plaza IntroductionThe objective of our study was to identify the diagnostic and therapeutic approaches in the different ENT Departments of Spain with respect to sudden deafness. We wanted to establish a basis to help to create a new nation-wide consensus, unifying treatmen...περισσότερα »
Primary Papillary Carcinoma in Thyroglossal Cysts
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
. Case Reports and Literature Review via Acta Otorrinolaringologica English Publication date: March–April 2016 *Source:*Acta Otorrinolaringologica (English Edition), Volume 67, Issue 2 Author(s): Andrés Chala, Andrés Álvarez, Álvaro Sanabria, Alejandro Gaitán The thyroglossal cyst can exceptionally appear as a primary cyst carcinoma. We discuss a series of 6 adult patients, assessed for long-lasting asymptomatic suprahyoid or lateral-to-larynx mass. The images showed a heterogeneous mass invading adjacent soft tissues. Fine needle aspiration biopsy did not contribute to diagnosis. We pe... περισσότερα »
Children From Foreign Bodies in the Airway
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
Complications in via Acta Otorrinolaringologica English Publication date: March–April 2016 *Source:*Acta Otorrinolaringologica (English Edition), Volume 67, Issue 2 Author(s): Hugo Rodríguez, Giselle Cuestas, Hugo Botto, Mary Nieto, Alejandro Cocciaglia, Desiderio Passali, Dario Gregori Introduction and objectivesForeign body aspiration in childhood is a common and potentially serious problem. Complications may be the result of the aspiration episode itself, delayed diagnosis or treatment. We describe our experience in a paediatric hospital in Argentina.MethodsWe retrospectively evalu...περισσότερα »
Wendler Glottoplasty and Voice-Therapy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
in Male-to-Female Transsexuals: Results in Pre and Post-Surgery Assessment via Acta Otorrinolaringologica English Publication date: March–April 2016 *Source:*Acta Otorrinolaringologica (English Edition), Volume 67, Issue 2 Author(s): Juan C. Casado, Carlos O’Connor, María S. Angulo, José A. Adrián IntroductionWith the development of new ENT techniques, many male transsexuals who wish to become women usually request a surgical procedure to raise the fundamental frequency of the voice (feminization). The ENT specialist and the voice-therapist have to use an interdisciplinary approach to ... περισσότερα »
Inter-ear difference (IED) through monothermal caloric screening testing (MCST)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Three New Strategies to Improve the Accuracy of Monothermal Caloric Screening Testing via Acta Otorrinolaringologica English Publication date: March–April 2016 *Source:*Acta Otorrinolaringologica (English Edition), Volume 67, Issue 2 Author(s): Emilio Domínguez-Durán, Antonio Gandul-Merchán, José Ignacio Tato-Gómez, Juan Ramón Lacalle-Remigio, Antonio Abrante-Jiménez, Francisco Esteban-Ortega ObjectiveThe objective was to find a way to estimate the value of inter-ear difference (IED) through monothermal caloric screening testing (MCST) that can be used at any laboratory, controlling an... περισσότερα »
Bilateral Recurrent Laryngeal Nerve Injury
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
in Total Thyroidectomy With or Without Intraoperative Neuromonitoring. Systematic Review and Meta-analysis via Acta Otorrinolaringologica English Publication date: March–April 2016 *Source:*Acta Otorrinolaringologica (English Edition), Volume 67, Issue 2 Author(s): José Luis Pardal-Refoyo, Carlos Ochoa-Sangrador Introduction and objectiveThe risk of producing bilateral laryngeal paralysis (BLP) in total thyroidectomy (TT) is low, but it is a concern for the surgeon and a serious safety incident that may compromise the airway, require reintubation or tracheostomy and cause serious seque...περισσότερα »
Behçet's Disease and Recurrent Aphthous Ulcer.Anticoagulant and Fibrinolytic Disorders
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Anticoagulant and Fibrinolytic Disorders in Patients with Behçet's Disease and Recurrent Aphthous Ulcer Chin J Physiol. Authors: Shang H, Ye JJ, Ji M, Wang FF, Zhu YY, Qi XM Abstract Behçet's disease (BD) is a chronic multisystemic inflammatory disorder characterized by recurrent oral and genital aphthous ulcers, uveitis and skin lesions. Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans. The pathogenesis and thrombopoiesis of BD and RAU have not been fully clarified. To reveal the haemostatic dysfunctions in the patients with BD and RAU, we evalu...περισσότερα »
LED, low and high-power laser (HPL) for the treatment of chemotherapy (CT)-induced oral mucositis (OM)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Comparative study among three different phototherapy protocols to treat chemotherapy-induced oral mucositis in hamsters.: J Biophotonics. 2016 Apr 23; Authors: Campos L, Cruz ÉP, Pereira FS, Arana-Chavez VE, Simões A Abstract In this study, clinical, biochemical and histological analysis were used to compare different phototherapies, including LED, low and high-power laser (HPL) for the treatment of chemotherapy (CT)-induced oral mucositis (OM). One-hundred-fifty hamsters were divided into five groups: C: control; CH: CT/OM induction; L: CT/OM induction and treatment with LED (635 ...περισσότερα »
Phototherapy protocols to treat chemotherapy-induced oral mucositis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Comparative study among three different phototherapy protocols to treat chemotherapy-induced oral mucositis in hamsters.: J Biophotonics. 2016 Apr 23; Authors: Campos L, Cruz ÉP, Pereira FS, Arana-Chavez VE, Simões A Abstract In this study, clinical, biochemical and histological analysis were used to compare different phototherapies, including LED, low and high-power laser (HPL) for the treatment of chemotherapy (CT)-induced oral mucositis (OM). One-hundred-fifty hamsters were divided into five groups: C: control; CH: CT/OM induction; L: CT/OM induction and treatment with LED (635 ...περισσότερα »
Pediatric head and neck pilomatrixoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Review of via International Journal of Pediatric Otorhinolaryngology Publication date: June 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 85 Author(s): Yehuda Schwarz, Jacob Pitaro, Sofia Waissbluth, Sam J. Daniel IntroductionPilomatrixoma is a benign skin tumor, which is commonly found in the head and neck region. It usually presents as an isolated lesion and rarely undergoes malignant transformation. It is not uncommon for these tumors to be misdiagnosed.ObjectiveTo review the clinical characteristics of head and neck pilomatrixomas in the pediatric pop...περισσότερα »
Tumor Size and Bilateral Involvement in Papillary Thyroid Carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Association between Background. Tumor multifocality and bilaterality of papillary thyroid carcinoma (PTC) are important factors when selecting the most appropriate surgical procedure. The aim of this study was to assess the bilaterality rate in PTC and the relationship between the tumor size and bilaterality. Materials and Methods. Thyroidectomy specimens with a diagnosis of PTC were retrospectively reviewed in the Pathology Department of a tertiary care medical center. Specimens were divided into three groups according to the size of the primary and contralateral tumor foci. Tum... περισσότερα »
Reconstruction of human oncological tracheal defects with xenogenic acellular dermal matrix
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 43 δευτερόλεπτα
Reconstruction of human oncological tracheal defects with xenogenic acellular dermal matrix: This study aimed to explore the effectiveness of xenogenic acellular dermal matrix (xeno-ADM) in tracheal reconstruction. AbstractObjective This study aimed to explore the effectiveness of xenogenic acellular dermal matrix (xeno-ADM) in tracheal reconstruction. Method Two patients were treated with this surgical method to reconstruct the trachea in 2013. The patients were diagnosed with tracheal adenoid cystic carcinoma by histopathological biopsy. The tumor was resected with half of the t... περισσότερα »
Dietary magnesium, calcium:magnesium ratio and risk of reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
: a population-based case-control study.: Br J Nutr. 2016;115(2):342-50 Authors: Dai Q, Cantwell MM, Murray LJ, Zheng W, Anderson LA, Coleman HG, FINBAR study group Abstract Evidence suggests a role of Mg and the ratio of Ca:Mg intakes in the prevention of colonic carcinogenesis. The association between these nutrients and oesophageal adenocarcinoma - a tumour with increasing incidence in developed countries and poor survival rates - has yet to be explored. The aim of this investigation was to explore the association between Mg intake and related nutrients and risk of oesophageal ...περισσότερα »
Diverticulitis And The Age Factor
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
Does Age Matter?: Abstract Aim Acute diverticulitis has been traditionally associated with worse outcome in young patients, indicating a more aggressive surgical approach. The aim of this study is to assess whether acute diverticulitis is more virulent in young patients. Methods A retrospective cross-sectional study included all first time patient admissions for acute diverticulitis between January 2004 and December 2013. Patients Demographics, clinical and surgical data were recorded and analyzed. Patients were divided into 2 groups: patients 50 years old and younger and patients... περισσότερα »
G9a histone methyltransferase inhibitor BIX01294 promotes expansion of adult cardiac progenitor cells without changing their phenotype or differentiation potential
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 44 δευτερόλεπτα
Abstract Objectives As a follow-up to our previous reports showing that the G9a histone methyltransferase-specific inhibitor BIX01294 enhances bone marrow cell cardiac potential, this drug was examined for its effects on cardiomyocytes and mouse cardiac progenitor cells (CPCs). Materials and methods Cardiomyocytes and cardiac explants were cultured ± BIX01294, and examined for changes in cardiac… Continue reading G9a histone methyltransferase inhibitor BIX01294 promotes expansion of adult cardiac progenitor cells without changing their phenotype or differentiation potential
Establishment and adipocyte differentiation of polycystic ovary syndrome-derived induced pluripotent stem cells
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 44 δευτερόλεπτα
Abstract Objective To establish a new biological cell model and approach to mimic abnormal lipid metabolism of polycystic ovary syndrome (PCOS) in vitro. Materials and methods Epithelial cells from PCOS patients were reprogrammed to pluripotency by retroviral transduction using defined factors. Morphology, growth characteristics, karyotype, gene expression and differentiation in vitro and in vivo were… Continue reading Establishment and adipocyte differentiation of polycystic ovary syndrome-derived induced pluripotent stem cells
G9a histone methyltransferase inhibitor BIX01294 promotes expansion of adult cardiac progenitor cells without changing their phenotype or differentiation potential
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 44 δευτερόλεπτα
Abstract Objectives As a follow-up to our previous reports showing that the G9a histone methyltransferase-specific inhibitor BIX01294 enhances bone marrow cell cardiac potential, this drug was examined for its effects on cardiomyocytes and mouse cardiac progenitor cells (CPCs). Materials and methods Cardiomyocytes and cardiac explants were cultured ± BIX01294, and examined for changes in cardiac… Continue reading G9a histone methyltransferase inhibitor BIX01294 promotes expansion of adult cardiac progenitor cells without changing their phenotype or differentiation potential
Establishment and adipocyte differentiation of polycystic ovary syndrome-derived induced pluripotent stem cells
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 44 δευτερόλεπτα
Abstract Objective To establish a new biological cell model and approach to mimic abnormal lipid metabolism of polycystic ovary syndrome (PCOS) in vitro. Materials and methods Epithelial cells from PCOS patients were reprogrammed to pluripotency by retroviral transduction using defined factors. Morphology, growth characteristics, karyotype, gene expression and differentiation in vitro and in vivo were… Continue reading Establishment and adipocyte differentiation of polycystic ovary syndrome-derived induced pluripotent stem cells
Esophageal Actinomycoses Mimicking Malignancy.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
Esophageal Actinomycoses Mimicking Malignancy Ann Thorac Surg. 2016 May;101(5):1967-70 Authors: Pillappa R, O'Brien TF, Sullivan JL, Weksler B Abstract Actinomycosis is caused by anaerobic bacteria and rarely affects the esophagus. We present a case of esophageal actinomycosis in a 55-year old woman that mimicked malignancy. The patient presented with dysphagia and weight loss. Preoperative esophagogastroscopic biopsy revealed purulent material, but was inconclusive. Endoscopic ultrasonography suggested esophageal cancer, and chest computed tomography showed a mass in the lower es... περισσότερα »
Human papillomavirus infection on initiating synchronous esophageal neoplasia
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
in patients with head and neck cancer.: Laryngoscope. 2016 May;126(5):1097-1102 Authors: Wang WL, Wang YC, Chang CY, Lo JL, Kuo YH, Hwang TZ, Wang CC, Mo LR, Lin JT, Lee CT Abstract OBJECTIVES/HYPOTHESIS: Human papillomavirus (HPV) is a risk factor for head and neck squamous cell carcinoma (HNSCC) as well as esophageal squamous cell carcinoma (ESCC). We aimed to investigate whether HPV infection underlies the field cancerization phenomenon over upper aerodigestive tract to develop synchronous multiple cancers. STUDY DESIGN: A case control study. METHODS: The presence and subtype... περισσότερα »
The oral mucosa of smoking and non-smoking qat chewers
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
Clinical and cytological study of Abstract ObjectiveThe study was conducted to investigate the role of qat and smoking habits on the prevalence of visible and cytological abnormalities in the oral mucosa among Yemenites. MethodsWe recruited 30 non-smoking and 30 smoking Yemenites chewing qat unilaterally for at least 5 years. We inspected oral cavities for the presence of lesions and took brush biopsies from the buccal mucosa/gingiva of the chewing/non-chewing region. ResultsAll visible oral lesions were flat and homogeneous, and cytological changes were detected frequently...περισσότερα »
Erlotinib and gefitinib responsiveness in head and neck cancer cell lines
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
—a comparing analysis with cetuximab: Abstract ObjectiveThe objective of this study is to examine the efficacy of erlotinib and gefitinib with respect to epidermal growth factor (EGF) and cetuximab response in head and neck cancer cell lines. Materials and methodsFive human head and neck carcinoma cell lines were treated with EGF, cetuximab, erlotinib, and gefitinib, and the effects were measured with a crystal violet assay. The efficacies of cetuximab, erlotinib, and gefitinib in clinically relevant concentrations were statistically analyzed. The expression of the epidermal gr... περισσότερα »
Prevalence of periodontitis in individuals with human leukocyte antigens (HLA) A9, B15, A2, and B5
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
Prevalence of periodontitis in individuals with human leukocyte antigens (HLA) A9, B15, A2, and B5: Abstract ObjectiveHuman leukocyte antigens (HLA) have been associated with periodontitis. Previous studies revealed HLA-A9 and HLA-B15 as potential susceptibility factors, while HLA-A2 and HLA-B5 might have protective effects. The aim of the study was to verify these associations in a group of HLA-typed blood donors with previously unknown periodontal status. Materials and methodsIn four German centers, 140 blood donors with known HLA class I status were enrolled and allocated to...περισσότερα »
Cytotoxicity and genotoxicity of natural resin-based experimental endodontic sealers
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
Cytotoxicity and genotoxicity of natural resin-based experimental endodontic sealers: Abstract ObjectivesThe development of endodontic sealers based on natural resins seems to be promising, given their improved biological properties. This study evaluated the cytotoxic and genotoxic effects of two experimental root canal sealers, based on extracts from *Copaifera multijuga* and *Ricinus communis* (castor oil polymer), comparing them to synthetic resin-based sealers: a single methacrylate-based, a multi-methacrylate-based, and an epoxy resin-based sealers. Materials and methodsS...περισσότερα »
The oral status and microorganisms in children with phenylketonuria and type 1 diabetes
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
Investigation of via Latest Results for Clinical Oral Investigations AbstractObjectiveThe aim of this study was to investigate the oral parameters that influence the caries risk and risk of developing periodontal disease in children with phenylketonuria (PKU) and type 1 diabetes compared to healthy children. Material and methodsTwo hundred and thirty-eight children between the ages of 3 and 18 years were recruited in the PKU, diabetes and healthy group. The decayed, missing and filled surfaces (dmfs/DMFS) index, papillary bleeding index (PBI) and the Silness & Löe Index were assessed...περισσότερα »
Bone scintigraphy predicts bisphosphonate-induced osteonecrosis of the jaw (BRONJ)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
in patients with metastatic castration-resistant prostate cancer (mCRPC) via Latest Results for Clinical Oral Investigations AbstractObjectivesThe aim of this study was to evaluate the role of bone scintigraphy (BS) in early prediction of clinically asymptomatic bisphosphonate (BP)-related osteonecrosis of the jaws (BRONJ) in patients with metastatic castration-resistant prostate cancer (mCRPC). Material and methodsBS of mCRPC patients treated with BP was evaluated for pathologic tracer uptake of the jaws in BS suspicious for BRONJ. Results were compared to development of clinically e...περισσότερα »
G9a histone methyltransferase inhibitor BIX01294 promotes expansion of adult cardiac progenitor cells without changing their phenotype or differentiation potential
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Abstract Objectives As a follow-up to our previous reports showing that the G9a histone methyltransferase-specific inhibitor BIX01294 enhances bone marrow cell cardiac potential, this drug was examined for its effects on cardiomyocytes and mouse cardiac progenitor cells (CPCs). Materials and methods Cardiomyocytes and cardiac explants were cultured ± BIX01294, and examined for changes in cardiac […]
Establishment and adipocyte differentiation of polycystic ovary syndrome-derived induced pluripotent stem cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 49 δευτερόλεπτα
Abstract Objective To establish a new biological cell model and approach to mimic abnormal lipid metabolism of polycystic ovary syndrome (PCOS) in vitro. Materials and methods Epithelial cells from PCOS patients were reprogrammed to pluripotency by retroviral transduction using defined factors. Morphology, growth characteristics, karyotype, gene expression and differentiation in vitro and in vivo were […]
Effects of cranberry components on IL-1β-stimulated production of IL-6, IL-8 and VEGF
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
by human TMJ synovial fibroblasts via Oral Biology Publication date: August 2016 *Source:*Archives of Oral Biology, Volume 68 Author(s): David A. Tipton, James Christian, Adam Blumer ObjectiveOsteoarthritis (OA) in the TMJ is characterized by deterioration of articular cartilage and secondary inflammatory changes. Interleukin-1β (IL-1β) stimulates IL-6, IL-8, and vascular endothelial growth factor (VEGF) in synovial fluid of TMJ with internal derangement and bony changes. The cranberry (Vaccinium macrocarpon) contains polyphenolic compounds that inhibit production of pro-inflammatory ...περισσότερα »
Bite force of children
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Bite force of children with repaired unilateral and bilateral cleft lip and palate via Oral Biology Publication date: August 2016 *Source:*Archives of Oral Biology, Volume 68 Author(s): Michele Alves Garcia, Daniela Rios, Heitor Marques Honório, Ivy Kiemle Trindade-Suedam ObjectiveTo assess the bite force (BF) of children with repaired cleft lip and palate (CLP).DesignChildren aged 6–12 years, with and without CLP, were divided into the following 5 groups: (1) control group (CON): 34 children without CLP (17 female, 17 male, mean age 8.2±1.4); (2) cleft lip group (CL): 31 children wit...περισσότερα »
Inhibition of Streptococcus mutans biofilm formation using extracts from Assam tea
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
compared to green tea via Oral Biology Publication date: August 2016 *Source:*Archives of Oral Biology, Volume 68 Author(s): Taketo Kawarai, Naoki Narisawa, Saori Yoneda, Yoshiaki Tsutsumi, Jun Ishikawa, Yasutaka Hoshino, Hidenobu Senpuku ObjectiveStreptococcus mutans, a gram-positive oral bacterium, has been identified as one of the principal etiological agents of human dental caries. To clarify the nature of the difference anti-biofilm effect against S. mutans between Assam tea from Camellia sinensis var. assamica, partially fermented, and green tea from Camellia sinensis, non-ferme...περισσότερα »
Pancreatic cancer risk tied to specific mouth bacteria
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
Pancreatic cancer risk tied to specific mouth bacteria: The presence of certain bacteria in the mouth may reveal increased risk for pancreatic cancer and enable earlier, more precise treatment, report investigators. Pancreatic cancer patients are known to be susceptible to gum disease, cavities, and poor oral health in general, say the study authors. That vulnerability led the research team to search for direct links between the makeup of bacteria driving oral disease and subsequent development of pancreatic cancer, a disease that often escapes early diagnosis and causes 40,000 US d... περισσότερα »
Commentary: What? A Resident as an Expert Witness?
Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 51 δευτερόλεπτα
The American legal system is adversarial. (1) It is a contest in which two or more parties assume opposing viewpoints. Accusations and demands are made, evidence developed and presented, and arguments made. All this proceeds according to statutory rules or common law. Finally, the "Trier of Fact," typically a jury or judge, assesses the facts and arguments in play and renders a decision as guided, again, by a set of rules that have been developed and refined over decades and even centuries of law. This article is protected by copyright. All rights reserved. from Anaesthesia via ... περισσότερα »
Haemolytic activity of subgingival bacteria is associated with periodontitis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα
Association of clinical parameters with periodontal bacteria haemolytic activity by Benedicta K. J. Wong, Neil R. McGregor, Henry L. Butt, Rachel Knight, Louise Ye Liu, Ivan B. Darby via Journal of Clinical Periodontology Abstract Aims To determine whether haemolytic activity of subgingival bacteria is associated with periodontitis clinical parameters and to identify which bacteria produce the haemolysins. Materials and methods Subgingival plaque samples from twenty-two untreated chronic periodontitis patients were investigated by culture and identified with MALDI-TOF MS. Results Total...περισσότερα »
The extracellular matrix (ECM)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα
Supramolecular hydrogel networks formed by molecular recognition of collagen and a peptide grafted to hyaluronic acid via Acta Biomaterialia Publication date: Available online 21 April 2016 *Source:*Acta Biomaterialia Author(s): Stefania Federico, Ulrich Nöchel, Candy Löwenberg, Andreas Lendlein, Axel T. Neffe The extracellular matrix (ECM) is a nano-structured, highly complex hydrogel, in which the macromolecules are organized primarily by non-covalent interactions. Here, in a biomimetic approach, the decorin-derived collagen-binding peptide LSELRLHNN was grafted to hyaluronic acid (... περισσότερα »
Decellularized cartilage-based hydrogel
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα
Approaching the compressive modulus of articular cartilage with a decellularized cartilage-based hydrogel via Acta Biomaterialia Publication date: Available online 22 April 2016 *Source:*Acta Biomaterialia Author(s): Emily C. Beck, Marilyn Barragan, Madeleine H. Tadros, Stevin H. Gehrke, Michael S. Detamore ECM-based materials are appealing for tissue engineering strategies because they may promote stem cell recruitment, cell infiltration, and cell differentiation without the need to supplement with additional biological factors. Cartilage ECM has recently shown potential to be chondro... περισσότερα »
Rate discrimination, gap detection and ranking of temporal pitch in cochlear implant users
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 52 δευτερόλεπτα
Rate discrimination, gap detection and ranking of temporal pitch in cochlear implant users: AbstractCochlear implant (CI) users have poor temporal pitch perception, as revealed by two key outcomes of rate discrimination tests: (i) rate discrimination thresholds (RDTs) are typically larger than the corresponding frequency difference limen for pure tones in normal hearing listeners, and (ii) above a few hundred pulses per second (i.e. the “upper limit” of pitch), CI users cannot discriminate further increases in pulse rate. Both RDTs at low rates and the upper limit of pitch vary acr... περισσότερα »
Cochlear implant and inflammation reaction
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
: safety study of a new steroid-eluting electrode via Hearing Research [image: S03785955.gif] Publication date: Available online 21 April 2016 *Source:*Hearing Research Author(s): L. Astolfi, E. Simoni, N. Giarbini, P. Giordano, M. Pannella, S. Hatzopoulos, A. Martini Dexamethasone is a common anti-inflammatory agent added to cochlear implants to reduce hearing loss due to electrode insertion trauma. We evaluated the safety of eluting silicone rods containing 10% dexamethasone in a Guinea pig model. Animals were implanted with a dexamethasone eluting silicone electrode (DER) or with ... περισσότερα »
Vocal Extent Measure (VEM) Assessing Phonomicrosurgical Outcomes in Vocal Fold Polyps
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 55 δευτερόλεπτα
The Value of via Voice Publication date: Available online 22 April 2016 *Source:*Journal of Voice Author(s): Tatjana Salmen, Tatiana Ermakova, Andreas Möller, Matthias Seipelt, Sebastian Weikert, Julius Rummich, Manfred Gross, Tadeus Nawka, Philipp P. Caffier ObjectiveThis study aimed to present vocal extent measure (VEM), demonstrate its changes with phonomicrosurgical treatment in patients with vocal fold polyps (VFPs), and to compare its performance to that of established vocal parameters.Study DesignThis is an individual cohort study.MethodsMicrolaryngoscopic ablation was execute... περισσότερα »
The cVEMPs Recorded Along the Sternocleidomastoid Muscles
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
The Cervical Vestibular-Evoked Myogenic Potentials (cVEMPs) Recorded Along the Sternocleidomastoid Muscles During Head Rotation and Flexion in Normal Human Subjects: ABSTRACTTone burst-evoked myogenic potentials recorded from tonically contracted sternocleidomastoid muscles (SCM) (cervical VEMP or cVEMP) are widely used to assess the vestibular function. Since the cVEMP response is mediated by the vestibulo-collic reflex (VCR) pathways, it is important to understand how the cVEMPs are determined by factors related to either the sensory components (vestibular end organs) or the moto... περισσότερα »
Typhoid fever
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Typhoid fever: An acute illness characterized by fever caused by infection with the bacterium Salmonella typhi. Typhoid fever has an insidious onset, with fever, headache, constipation, malaise, chills, and muscle pain. Diarrhea is uncommon, and vomiting is not usually severe. Confusion, delirium, intestinal perforation, and death may occur in severe cases. The disease is transmitted… Continue reading Typhoid fever
Asia Pacific Journal of Public Health
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Asia Pacific Journal of Public Health, published by SAGE Publications, last updated on 2016-04-22, available at http://aph.sagepub.com from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://aph.sagepub.com/ via IFTTT
Scars, Burns & Healing
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Scars, Burns & Healing, published by SAGE Publications, last updated on 2016-04-22, available at http://sbh.sagepub.com from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://sbh.sagepub.com/ via IFTTT
Intravascular clearance of disseminating Cryptococcus neoformans in the brain can be improved by enhancing neutrophil recruitment in mice
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Extrapulmonary dissemination of *Cryptococcus neoformans* (*C. neoformans*) is one of the most critical steps in the development of meningoencephalitis. Here, we report that clearance of the disseminating *C. neoformans* occurs within the brain microvasculature. Interestingly, the efficiency of the intravascular clearance in the brain is reduced compared to that in the lung. Intravascular clearance is mainly mediated by neutrophils, and complement C5a receptor signaling is crucial for mediating neutrophil recruitment in the vasculature. *C. neoformans*-stimulated actin polymeriza... περισσότερα »
Interaction of the LILRB1 inhibitory receptor with HLA class Ia dimers
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) has been reported to interact with a wide spectrum of HLA class I (HLA-I) molecules, albeit with different affinities determined by allelic polymorphisms and conformational features. HLA-G dimerization and the presence of intracellular Cys residues in HLA-B7 have been shown to be critical for their recognition by LILRB1. We hypothesized that dimerization of classical HLA class Ia molecules, previously detected in exosomes, might enhance their interaction with LILRB1. A soluble LILRB1-Fc fusion protein and a sens... περισσότερα »
Acute cerebral infarcts in multiple arterial territories associated with cardioembolism
Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Objectives It is generally believed that cardioembolism is the main cause of multiple acute cerebral infarcts (MACI). However, there are surprisingly few DWI studies and results are conflicting. Based on a large prospective study we hypothesized that MACI are associated with cardioembolism. Materials and methods We studied 2697 patients with acute cerebral infarcts between February 2006 and October 2013 who were prospectively registered in The Bergen NORSTROKE Registry. Among them, 2220 (82.3%) patients underwent magnetic resonance imaging (MRI) and 2125 (96%) of these 2220 patie... περισσότερα »
State selection in Markov models for panel data with application to psoriatic arthritis
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Statistics in medicine from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QwoPds via IFTTT
Processing of human Toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Immunity from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1rbhYS7 via IFTTT
p53 coordinates base excision repair to prevent genomic instability
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Nucleic Acids Research from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QwoPde via IFTTT
Evidence of Common Genetic Overlap Between Schizophrenia and Cognition
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Schizophrenia Bulletin from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1rbhYBB via IFTTT
Positron Emission Tomography and Magnetic Resonance Imaging of Cellular Inflammation in Patients with Abdominal Aortic Aneurysms
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
European Journal of Vascular and Endovascular Surgery from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QwoOGh via IFTTT
Oocyte development, meiosis and aneuploidy
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Seminars in Cell & Developmental Biology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1rbhZ8G via IFTTT
Increased percentages of regulatory T cells are associated with inflammatory and neuroendocrine responses to acute psychological stress and poorer health status in older men and women
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Psychopharmacology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QwoMhO via IFTTT
Crosstalk between endocannabinoid and immune systems: a potential dysregulation in depression?
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Psychopharmacology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1rbhZ8x via IFTTT
DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Haematologica from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QwoOpU via IFTTT
Binding of Hyaluronan to the Native Lymphatic Vessel Endothelial Receptor LYVE-1 Is Critically Dependent on Receptor Clustering and Hyaluronan Organization*
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
The Journal of Biological Chemistry from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1rbhWcX via IFTTT
Effect of treatment with geraniol on ovalbumin-induced allergic asthma in mice
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 2 ώρες
Publication date: Available online 22 April 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Zheng Xue, Xin-guang Zhang, Jie Wu, Wan-chao Xu, Li-qing Li, Fei Liu, Jian-er Yu BackgroundAsthma, a complex highly prevalent airway disease, is a major public health problem for which current treatment options are inadequate.ObjectiveTo evaluate the antiasthma activity of geraniol and investigate its underlying molecular mechanisms.MethodsIn a standard experimental asthma model, Balb/c mice were sensitized with ovalbumin, treated with geraniol (100 or 200 mg/kg) or a vehicle ...περισσότερα »
