Community-Associated Methicillin-Resistant Staphylococcus aureus
Comparative Genomics of Community-Associated Methicillin-Resistant Staphylococcus aureus Shows the Emergence of Clone ST8-USA300 in Geneva, Switzerland: *Background.* Previous investigations of community-associated methicillin-resistant *Staphylococcus aureus* (CA-MRSA) isolates have revealed a wide diversity of genetic backgrounds, with only sporadic occurrence of ST8-USA300, in Geneva, Switzerland. We conducted a molecular epidemiologic analysis to identify the origin of a sudden increase of ST8 PVL–positive isolates in Geneva during 2013. *Methods.* On the basis of prospective ... περισσότερα »
Dengue Virus (DENV) Neutralizing Antibody Kinetics in Children After Symptomatic Primary and Postprimary DENV Infection
Dengue Virus (DENV) Neutralizing Antibody Kinetics in Children After Symptomatic Primary and Postprimary DENV Infection: The immune response to dengue virus (DENV) infection is complex and not fully understood. Using longitudinal data from 181 children with dengue in Thailand who were followed for up to 3 years, we describe neutralizing antibody kinetics following symptomatic DENV infection. We observed that antibody titers varied by serotype, homotypic vs heterotypic responses, and primary versus postprimary infections. The rates of change in antibody titers over time varied betwe... περισσότερα »
Anal Oncogenic Human Papillomavirus Infection
Prevalence of and Risk Factors for Anal Oncogenic Human Papillomavirus Infection Among HIV-Infected Women in France in the Combination Antiretroviral Therapy Era: *Background.* Little is known about the type-specific prevalence of anal human papillomavirus (HPV) infection and risk factors for anal high-risk (HR) HPV infection in human immunodeficiency virus (HIV)–infected women. *Methods.* A cross-sectional study of anal and cervical HPV infection was nested within a gynecological cohort of HIV-infected women. Specimens were tested for type-specific DNA using a polymerase chain rea...περισσότερα »
Antimicrobial Blue Light Inactivation of Gram-Negative Pathogens in Biofilms: In Vitro and In Vivo Studies
Antimicrobial Blue Light Inactivation of Gram-Negative Pathogens in Biofilms: In Vitro and In Vivo Studies: *Background.* Biofilms affect >80% bacterial infections in human and are usually difficult to eradicate because of their inherent drug resistance. *Methods.* We investigated the effectiveness of antimicrobial blue light (aBL) (wavelength, 415 nm) for inactivating *Acinetobacter baumannii* or *Pseudomonas aeruginosa* biofilms in 96-well microplates or infected mouse burn wounds. *Results.* In vitro, in 96-well microplates, exposure of 24-hour-old and 72-hour-old *A. baumannii*... περισσότερα »
Varicella Zoster Virus Infection in Granulomatous Arteritis of the Aorta
Varicella Zoster Virus Infection in Granulomatous Arteritis of the Aorta: Granulomatous arteritis characterizes the pathology of giant cell arteritis (GCA), granulomatous aortitis, and intracerebral varicella zoster virus (VZV) vasculopathy. Because intracerebral VZV vasculopathy and GCA are strongly associated with productive VZV infection in cerebral and temporal arteries, respectively, we evaluated human aortas for VZV antigen and VZV DNA. Using 3 different anti-VZV antibodies, we identified VZV antigen in all of 11 aortas with pathologically verified granulomatous arteritis, in ... περισσότερα »
Inhaled corticosteroids and HPA axis suppression
: how important is it and how should it be managed?: Summary Inhaled corticosteroids (ICS) are established as a cornerstone of management for patients with bronchoconstrictive lung disease. However, systemic absorption may lead to suppression of the hypothalamic-pituitary-adrenal (HPA) axis in a significant minority of patients. This is more likely in ‘higher risk’ patients exposed to high cumulative ICS doses, and in those treated with frequent oral corticosteroids or drugs which inhibit cytochrome p450 3A4. HPA axis suppression is frequently unrecognised, such that some patients,...περισσότερα »
Pituitary Apoplexy- Bespoke Patient Management Allows Good Clinical Outcome
Pituitary Apoplexy- Bespoke Patient Management Allows Good Clinical Outcome: Abstract Objective To describe the clinical presentation, management and outcome of pituitary apoplexy from a single-centre and retrospectively apply the Pituitary Apoplexy Score (PAS). Design Retrospective review of patients presenting with classical pituitary apoplexy to a single neurosurgical centre in the Greater Manchester region. Results A total of 31 cases with classical pituitary apoplexy were identified between 2005 and 2014. The mean age at presentation was 55 years and there were 19 males. In onl...περισσότερα »
Primary ectopic substernal thyroid cancer with trachea relapse: a case report and opinions of management.
*Primary ectopic substernal thyroid cancer with trachea relapse: a case report and opinions of management.* World J Surg Oncol. 2016;14(1):94 Authors: Ma RM, Lv L, Zheng SR, You J, Huang DP, Guo GL Abstract BACKGROUND: Ectopic substernal thyroid is a rare symptom of thyroid disease that entirely results from the developmental defects at early stages of thyroid embryogenesis and during its descent. Cases were seldom reported as primary ectopic substernal thyroid cancer, especially those with severe local invasion and tracheal relapse. CASE PRESENTATION: In this report, the patient ...περισσότερα »
A National Perspective of the Risk, Presentation, and Outcomes of Pediatric Thyroid Cancer.
*A National Perspective of the Risk, Presentation, and Outcomes of Pediatric Thyroid Cancer.* JAMA Otolaryngol Head Neck Surg. 2016 Mar 31; Authors: Al-Qurayshi Z, Hauch A, Srivastav S, Aslam R, Friedlander P, Kandil E Abstract Importance: Thyroid cancer is the most common endocrine malignant neoplasm in children and adolescents. Despite a more advanced presentation of thyroid cancer, younger patients tend to have a more favorable prognosis and a lower mortality rate than adults with thyroid cancer. Objective: To examine the presentation and outcomes of thyroid cancer in pediatri... περισσότερα »
ZEB1 in thyroid cancer
ZEB1 in thyroid cancer: Yan Zhang,* Gang Liu,* Shihe Wu, Futing Jiang, Jiangping Xie, Yuhong Wang Department of General Surgery, Navy General Hospital of Chinese PLA, Beijing, People’s Republic of China *These authors contributed equally to this work Objective: Transcription factor zinc finger E-box-binding homeobox 1 (ZEB1), as one of the key inducers of epithelial-mesenchymal transition, has been reported to be regulated by microRNA-144 and Bcl-2-associated athanogene 3, which both promote thyroid cancer cell invasion. However, the involvement of ZEB1 in thyroid cancer ... περισσότερα »
Meta-analysis of the effectiveness of esomeprazole in gastroesophageal reflux disease and Helicobacter pylori infection.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Meta-analysis of the effectiveness of esomeprazole in gastroesophageal reflux disease and Helicobacter pylori infection.* J Clin Pharm Ther. 2015 Aug;40(4):368-75 Authors: Teng M, Khoo AL, Zhao YJ, Lin L, Lim BP, Wu TS, Dan YY Abstract WHAT IS KNOWN AND OBJECTIVE: Proton pump inhibitors (PPIs) are one of the most widely used classes of drugs. However, the quantum clinical benefit of newer and more expensive PPIs over the older generation PPIs remains uncertain. This meta-analysis sought to assess the clinical and ... περισσότερα »
Correlation between hypersensitivity induced by esophageal acid infusion and the baseline impedance level in patients with suspected gastroesophageal reflux.
[image: http:--production.springer.de-OnlineReso] Related Articles *Correlation between hypersensitivity induced by esophageal acid infusion and the baseline impedance level in patients with suspected gastroesophageal reflux.* J Gastroenterol. 2015 Jul;50(7):735-43 Authors: Seo AY, Shin CM, Kim N, Yoon H, Park YS, Lee DH Abstract OBJECTIVES: To evaluate the relevance between the pH parameters and baseline impedance level or esophageal hypomotility in patients with suspected gastroesophageal reflux. METHOD: The recordings of 51 patients with heartburn, acid regurgitation, globus o... περισσότερα »
The utility of endoscopy and multichannel intraluminal impedance testing in children with cough and wheezing.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *The utility of endoscopy and multichannel intraluminal impedance testing in children with cough and wheezing.* Pediatr Pulmonol. 2014 Nov;49(11):1090-6 Authors: Rosen R, Amirault J, Johnston N, Haver K, Khatwa U, Rubinstein E, Nurko S Abstract BACKGROUND: Gastroesophageal reflux (GER) has been implicated as a causal factor in respiratory disease but prior studies have focused on the role of acid alone in the genesis of symptoms. Prior studies have relied on pH probe testing but this is blind to non-acid reflux wh... περισσότερα »
Robust Intensity Modulated Proton Therapy (IMPT) Increases Estimated Clinical Benefit in Head and Neck Cancer Patients.
*Robust Intensity Modulated Proton Therapy (IMPT) Increases Estimated Clinical Benefit in Head and Neck Cancer Patients.* PLoS One. 2016;11(3):e0152477 Authors: van Dijk LV, Steenbakkers RJ, Ten Haken B, van der Laan HP, van 't Veld AA, Langendijk JA, Korevaar EW Abstract PURPOSE: To compare the clinical benefit of robust optimized Intensity Modulated Proton Therapy (minimax IMPT) with current photon Intensity Modulated Radiation Therapy (IMRT) and PTV-based IMPT for head and neck cancer (HNC) patients. The clinical benefit is quantified in terms of both Normal Tissue Complicatio... περισσότερα »
Laparoscopic versus open transhiatal oesophagectomy for oesophageal cancer.
*Laparoscopic versus open transhiatal oesophagectomy for oesophageal cancer.* Cochrane Database Syst Rev. 2016 Mar 31;3:CD011390 Authors: Gurusamy KS, Pallari E, Midya S, Mughal M Abstract BACKGROUND: Surgery is the preferred treatment for resectable oesophageal cancers, and can be performed in different ways. Transhiatal oesophagectomy (oesophagectomy without thoracotomy, with a cervical anastomosis) is one way to resect oesophageal cancers. It can be performed laparoscopically or by open method. With other organs, laparoscopic surgery has been shown to reduce complications and ... περισσότερα »
Cardiac autonomic dysfunction in patients with gastroesophageal reflux disease.
[image: http:--http://ift.tt/1YyhL4R] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Cardiac autonomic dysfunction in patients with gastroesophageal reflux disease.* World J Gastroenterol. 2015 Jun 14;21(22):6982-9 Authors: Milovanovic B, Filipovic B, Mutavdzin S, Zdravkovic M, Gligorijevic T, Paunovic J, Arsic M Abstract AIM: To investigate autonomic nervous function in patients with a diagnosis of gastroesophageal reflux disease (GERD). METHODS: The investigation was performed on 29 patients (14 men), aged 18-80 years (51.14 ± 18.34), who were referred to our Neurocardi... περισσότερα »
Esomeprazole regimens for reflux symptoms in Chinese patients with chronic gastritis.
[image: http:--http://ift.tt/1YyhL4R] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Esomeprazole regimens for reflux symptoms in Chinese patients with chronic gastritis.* World J Gastroenterol. 2015 Jun 14;21(22):6965-73 Authors: Sun J, Yuan YZ, Hou XH, Zou DW, Lu B, Chen MH, Liu F, Wu KC, Zou XP, Li YQ, Zhou LY Abstract AIM: To compare symptom control with esomeprazole regimens for non-erosive reflux disease and chronic gastritis in patients with a negative endoscopy. METHODS: This randomized, open-label study was designed in line with clinical practice in China. Patien... περισσότερα »
The Role of Gastroesophageal Reflux and Other Factors during Progression to Esophageal Adenocarcinoma.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *The Role of Gastroesophageal Reflux and Other Factors during Progression to Esophageal Adenocarcinoma.* Cancer Epidemiol Biomarkers Prev. 2015 Jul;24(7):1012-23 Authors: Hazelton WD, Curtius K, Inadomi JM, Vaughan TL, Meza R, Rubenstein JH, Hur C, Luebeck EG Abstract BACKGROUND: U.S. esophageal adenocarcinoma (EAC) incidence increased over 5-fold between 1975 and 2009. Symptomatic gastroesophageal reflux disease (sGERD) elevates the risk for EAC. However, a simple calculation suggests that changes in sGERD prevale... περισσότερα »
Meta-analysis of the effectiveness of esomeprazole in gastroesophageal reflux disease and Helicobacter pylori infection.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Meta-analysis of the effectiveness of esomeprazole in gastroesophageal reflux disease and Helicobacter pylori infection.* J Clin Pharm Ther. 2015 Aug;40(4):368-75 Authors: Teng M, Khoo AL, Zhao YJ, Lin L, Lim BP, Wu TS, Dan YY Abstract WHAT IS KNOWN AND OBJECTIVE: Proton pump inhibitors (PPIs) are one of the most widely used classes of drugs. However, the quantum clinical benefit of newer and more expensive PPIs over the older generation PPIs remains uncertain. This meta-analysis sought to assess the clinical and s... περισσότερα »
Correlation between hypersensitivity induced by esophageal acid infusion and the baseline impedance level in patients with suspected gastroesophageal reflux.
[image: http:--production.springer.de-OnlineReso] Related Articles *Correlation between hypersensitivity induced by esophageal acid infusion and the baseline impedance level in patients with suspected gastroesophageal reflux.* J Gastroenterol. 2015 Jul;50(7):735-43 Authors: Seo AY, Shin CM, Kim N, Yoon H, Park YS, Lee DH Abstract OBJECTIVES: To evaluate the relevance between the pH parameters and baseline impedance level or esophageal hypomotility in patients with suspected gastroesophageal reflux. METHOD: The recordings of 51 patients with heartburn, acid regurgitation, globus or... περισσότερα »
The utility of endoscopy and multichannel intraluminal impedance testing in children with cough and wheezing.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *The utility of endoscopy and multichannel intraluminal impedance testing in children with cough and wheezing.* Pediatr Pulmonol. 2014 Nov;49(11):1090-6 Authors: Rosen R, Amirault J, Johnston N, Haver K, Khatwa U, Rubinstein E, Nurko S Abstract BACKGROUND: Gastroesophageal reflux (GER) has been implicated as a causal factor in respiratory disease but prior studies have focused on the role of acid alone in the genesis of symptoms. Prior studies have relied on pH probe testing but this is blind to non-acid reflux whi... περισσότερα »
Cardiac autonomic dysfunction in patients with gastroesophageal reflux disease.
[image: http:--http://ift.tt/1YyhL4R] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Cardiac autonomic dysfunction in patients with gastroesophageal reflux disease.* World J Gastroenterol. 2015 Jun 14;21(22):6982-9 Authors: Milovanovic B, Filipovic B, Mutavdzin S, Zdravkovic M, Gligorijevic T, Paunovic J, Arsic M Abstract AIM: To investigate autonomic nervous function in patients with a diagnosis of gastroesophageal reflux disease (GERD). METHODS: The investigation was performed on 29 patients (14 men), aged 18-80 years (51.14 ± 18.34), who were referred to our Neurocard... περισσότερα »
Esomeprazole regimens for reflux symptoms in Chinese patients with chronic gastritis.
[image: http:--http://ift.tt/1YyhL4R] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Esomeprazole regimens for reflux symptoms in Chinese patients with chronic gastritis.* World J Gastroenterol. 2015 Jun 14;21(22):6965-73 Authors: Sun J, Yuan YZ, Hou XH, Zou DW, Lu B, Chen MH, Liu F, Wu KC, Zou XP, Li YQ, Zhou LY Abstract AIM: To compare symptom control with esomeprazole regimens for non-erosive reflux disease and chronic gastritis in patients with a negative endoscopy. METHODS: This randomized, open-label study was designed in line with clinical practice in China. Patie... περισσότερα »
The Role of Gastroesophageal Reflux and Other Factors during Progression to Esophageal Adenocarcinoma.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *The Role of Gastroesophageal Reflux and Other Factors during Progression to Esophageal Adenocarcinoma.* Cancer Epidemiol Biomarkers Prev. 2015 Jul;24(7):1012-23 Authors: Hazelton WD, Curtius K, Inadomi JM, Vaughan TL, Meza R, Rubenstein JH, Hur C, Luebeck EG Abstract BACKGROUND: U.S. esophageal adenocarcinoma (EAC) incidence increased over 5-fold between 1975 and 2009. Symptomatic gastroesophageal reflux disease (sGERD) elevates the risk for EAC. However, a simple calculation suggests that changes in sGERD preval... περισσότερα »
Overuse of PET to monitor lung or oesophageal cancers
[News] [image: bestscience_banner_287x140.jpg] An observational study has found that hospitals in the USA vary widely in the use of positron emission tomography (PET) scans to detect recurrence in patients who are asymptomatic after treatment for lung or oesophageal cancer; furthermore, increasing PET use did not improve 2-year survival of patients.
Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S): a multicentre cohort study
[Articles] Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S): a multicentre cohort study: [image: gr1.sml] Our proposed ICON-S staging system for HPV+ oropharyngeal cancer is suitable for the 8th edition of the Union for International Cancer Control/American Joint Committee on Cancer TNM classification. Future work is needed to ascertain whether T and N categories should be further refined and whether non-anatomical factors might augment the full classificati... περισσότερα »
A TNM classification for HPV+ oropharyngeal cancer
[Comment] [image: bestscience_banner_287x140.jpg] Since the emergence and recognition of human papillomavirus-related (HPV+) oropharyngeal squamous-cell carcinoma as a distinct clinical entity, which has a more favourable prognosis compared with head and neck cancers arising from non-oropharyngeal sites and oropharyngeal cancer not associated with HPV (HPV–), clinicians have realised the inadequacy of the American Joint Cancer Committee on Cancer (AJCC) and Union for International Cancer Control (UICC) TNM staging classification for this disease.
Metformin for cancer prevention: a reason for optimism
[Comment] [image: main.pdf.png] Obesity and its metabolic complications, including diabetes, have been associated with an increased risk of several cancers.1 The global obesity epidemic has fuelled a sustained rise in obesity-related cancers, especially in resource-poor regions with few options for population-based screening. Thus, the potential use of metformin as a novel cancer prevention strategy has generated much excitement in view of its low cost, favourable safety profile, and its potential for biological specificity in disrupting the association between obesity and ca... περισσότερα »
The role of molecular testing in soft tissue sarcoma diagnosis
[Comment] [image: fx1.sml] What is the true fidelity of the expert human eye and brain in affirming an accurate sarcoma diagnosis? The study by Antoine Italiano and colleagues1 aims to answer this question by linking diagnoses made by sarcoma experts to molecular genetic testing done with fluorescence in-situ hybridisation (FISH), PCR, or reverse transcriptase-PCR for six soft tissue sarcoma subtypes. This level IV diagnostic and therapeutic study included 384 patients at 32 centres managed by the French Sarcoma Group. Sarcoma subtypes included dermatofibrosarcoma protuberans, d...περισσότερα »
Paediatric extracranial germ-cell tumours
[Review] [image: gr1.sml] Management of paediatric extracranial germ-cell tumours carries a unique set of challenges. Germ-cell tumours are a heterogeneous group of neoplasms that present across a wide age range and vary in site, histology, and clinical behaviour. Patients with germ-cell tumours are managed by a diverse array of specialists. Thus, staging, risk stratification, and treatment approaches for germ-cell tumours have evolved disparately along several trajectories. Paediatric germ-cell tumours differ from the adolescent and adult disease in many ways, leading to compl...περισσότερα »
Let's talk about cancer: communication and patient care
[Cancer and Society] [image: main.pdf.png] Diagnosed with incurable prostate cancer, Andrew McDonald (former Chief Executive of Independent Parliamentary Standards Authority) delivers a powerful and thought-provoking lecture highlighting issues around communication that still bedevil medical care. Drawing on his personal experiences, Andrew proposes solutions on how to improve patient care, supporting his arguments with data by Marie Curie, a British charity providing care and support through terminal illness. The lecture comprised of five scenes that re-enact the doctor–patient... περισσότερα »
Omalizumab’s Impact on Total and Allergen-Specific IgE Levels: A Polyclonal Story
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Int Arch Allergy Immunol 2016;169:69-70 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/21WcS7n via IFTTT
The Role of Platelets in Chronic Urticaria
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Background: Platelets are implicated in many pathophysiological processes, including inflammation and immunity. Ever-growing evidence suggests the active involvement of platelets in the pathogenesis of various inflammatory disorders, including cutaneous inflammatory diseases. A limited number of studies have investigated the role of platelets in chronic urticaria (CU). In this review, we summarize the current knowledge regarding […]
A novel approach for targeted elimination of CSPG4-positive triple-negative breast cancer cells using a MAP tau-based fusion protein
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
Abstract Chondroitin sulfate proteoglycan 4 (CSPG4) has been identified as a highly promising target antigen for immunotherapy of triple-negative breast cancer (TNBC). TNBC represents a highly aggressive heterogeneous group of tumors lacking expression of estrogen, progesterone, and human epidermal growth factor receptor 2 (HER2). TNBC is particularly prevalent among young premenopausal women. No suitable targeted […]
Understanding N-acetyl-L-glutamate Synthase Deficiency: Mutational Spectrum, Impact of Clinical Mutations on Enzyme Functionality, and Structural Considerations
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 17 δευτερόλεπτα
ABSTRACT N-acetyl-L-glutamate synthase (NAGS) deficiency (NAGSD), the rarest urea cycle defect, is clinically indistinguishable from carbamoyl phosphate synthetase 1 deficiency, rendering the identification of NAGS gene mutations key for differentiation, which is crucial, as only NAGSD has substitutive therapy. Over the last 13 years we have identified 43 patients from 33 families with NAGS mutations, […]
Fuchs syndrome or erythema multiforme major, uncommon or underdiagnosed?
[image: http:--http://ift.tt/1RtpDVA] Related Articles *Fuchs syndrome or erythema multiforme major, uncommon or underdiagnosed?* Indian J Dermatol Venereol Leprol. 2015 Jul-Aug;81(4):403-5 Authors: Mangal S, Narang T, Saikia UN, Kumaran MS PMID: 26087085 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1MZ7Xfh via IFTTT
Identification of Stevens-Johnson syndrome and toxic epidermal necrolysis in electronic health record databases.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Identification of Stevens-Johnson syndrome and toxic epidermal necrolysis in electronic health record databases.* Pharmacoepidemiol Drug Saf. 2015 Jul;24(7):684-92 Authors: Davis RL, Gallagher MA, Asgari MM, Eide MJ, Margolis DJ, Macy E, Burmester JK, Selvam N, Boscarino JA, Cromwell LF, Feigelson HS, Kuntz JL, Pawloski PA, Penfold RB, Raebel MA, Sridhar G, Wu A, La Grenade LA, Pacanowski MA, Pinheiro SP Abstract BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) carry a high mortalit... περισσότερα »
Relapsing polychondritis with initial presentations of recurrent negative-pressure pulmonary edema and acute respiratory failure.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Relapsing polychondritis with initial presentations of recurrent negative-pressure pulmonary edema and acute respiratory failure.* Respir Care. 2015 May;60(5):e101-4 Authors: Wu MF, Li YS, Hung CY, Chao WC, Fu ZY, Kao KC, Huang CC, Tsai YH, Hsieh MJ Abstract Relapsing polychondritis is a rare autoimmune disease causing inflammation in cartilaginous structures and other tissues throughout the body. Negative-pressure pulmonary edema (NPPE) due to laryngeal swelling from relapsing polychondritis is rare and has not ... περισσότερα »
Spatial orientation and mechanical properties of the human trachea: a computed tomography study.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Spatial orientation and mechanical properties of the human trachea: a computed tomography study.* Respir Care. 2015 Apr;60(4):561-6 Authors: Zanella A, Cressoni M, Ferlicca D, Chiurazzi C, Epp M, Rovati C, Chiumello D, Pesenti A, Gattinoni L, Kolobow T Abstract BACKGROUND: The literature generally describes the trachea as oriented toward the right and back, but there is very little detailed characterization. Therefore, the aim of this study was to precisely determine the spatial orientation and to better characte... περισσότερα »
Expiratory Reserve Volume During Slow Expiration With Glottis Opened in Infralateral Decubitus Position (ELTGOL) in Chronic Pulmonary Disease: Technique Description and Reproducibility.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Expiratory Reserve Volume During Slow Expiration With Glottis Opened in Infralateral Decubitus Position (ELTGOL) in Chronic Pulmonary Disease: Technique Description and Reproducibility.* Respir Care. 2015 Mar;60(3):406-11 Authors: Lanza FC, Alves CS, dos Santos RL, de Camargo AA, Dal Corso S Abstract BACKGROUND: There has not been a detailed description of expiratory reserve volume (ERV) during slow expiration with glottis open in infralateral decubitus position (ELTGOL, for Expiration Lente Totale Glotte Ouverte ... περισσότερα »
Strain modulations as a mechanism to reduce stress relaxation in laryngeal tissues.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Strain modulations as a mechanism to reduce stress relaxation in laryngeal tissues.* PLoS One. 2014;9(3):e90762 Authors: Hunter EJ, Siegmund T, Chan RW Abstract Vocal fold tissues in animal and human species undergo deformation processes at several types of loading rates: a slow strain involved in vocal fold posturing (on the order of 1 Hz or so), cyclic and faster posturing often found in speech tasks or vocal embellishment (1-10 Hz), and shear strain associated with vocal fold vibrati... περισσότερα »
Vein imaging laser reduces bruising in bruise-prone botulinum toxin injected patients.
*Vein imaging laser reduces bruising in bruise-prone botulinum toxin injected patients.* J Cosmet Laser Ther. 2016 Mar 31;:1-3 Authors: Lowe NJ, Halliday D Abstract BACKGROUND: Injection-related bruising is a common complication of many injectable treatments including facial injections of botulinum toxin (BTX) for aesthetic use. OBJECTIVE: We have investigated the use of a vein imaging laser (VIL) to observe otherwise non-visible subcutaneous blood vessels in 40 patients who had a history of bruising with past BTX injections to the face during the previous 12 months. METHODS: Ove...περισσότερα »
Immunological off-target effects of imatinib.
*Immunological off-target effects of imatinib.* Nat Rev Clin Oncol. 2016 Mar 31; Authors: Zitvogel L, Rusakiewicz S, Routy B, Ayyoub M, Kroemer G Abstract Around 15 years ago, imatinib mesylate (Gleevec(®) or Glivec(®), Novartis, Switzerland) became the very first 'targeted' anticancer drug to be clinically approved. This drug constitutes the quintessential example of a successful precision medicine that has truly changed the fate of patients with Philadelphia-chromosome-positive chronic myeloid leukaemia (CML) and gastrointestinal stromal tumours by targeting the oncogenic driver... περισσότερα »
Treating cancer with selective CDK4/6 inhibitors.
*Treating cancer with selective CDK4/6 inhibitors.* Nat Rev Clin Oncol. 2016 Mar 31; Authors: O'Leary B, Finn RS, Turner NC Abstract Uncontrolled cellular proliferation, mediated by dysregulation of the cell-cycle machinery and activation of cyclin-dependent kinases (CDKs) to promote cell-cycle progression, lies at the heart of cancer as a pathological process. Clinical implementation of first-generation, nonselective CDK inhibitors, designed to inhibit this proliferation, was originally hampered by the high risk of toxicity and lack of efficacy noted with these agents. The emerg... περισσότερα »
Immunotherapy: Clonal neoantigens and immune response: a balancing act.
*Immunotherapy: Clonal neoantigens and immune response: a balancing act.* Nat Rev Clin Oncol. 2016 Mar 31; Authors: Hutchinson L PMID: 27030076 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1UY9sSH via IFTTT
Evaluation and management of pancreatic lesions in patients with von Hippel-Lindau disease.
*Evaluation and management of pancreatic lesions in patients with von Hippel-Lindau disease.* Nat Rev Clin Oncol. 2016 Mar 31; Authors: Keutgen XM, Hammel P, Choyke PL, Libutti SK, Jonasch E, Kebebew E Abstract von Hippel-Lindau (VHL) disease is a heritable cancer-predisposition syndrome with multiorgan involvement. Pancreatic lesions are detected in approximately two-thirds of patients with VHL disease at some point during their lifetime. In these patients, cystic pancreatic lesions are almost exclusively benign and, unless symptomatic, do not require surgical or endoscopic inte...περισσότερα »
New technology: Integrated approach to genetic profiling of blood cancers.
*New technology: Integrated approach to genetic profiling of blood cancers.* Nat Rev Clin Oncol. 2016 Mar 31; Authors: Killock D PMID: 27030074 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/21Wafm6 via IFTTT
Immunotherapy: Atezolizumab becomes POPLAR.
*Immunotherapy: Atezolizumab becomes POPLAR.* Nat Rev Clin Oncol. 2016 Mar 31; Authors: Romero D PMID: 27030073 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1Tnkrni via IFTTT
Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospitalized with influenza A.
*Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospitalized with influenza A.* MAbs. 2016 Mar 31;:0 Authors: Gupta P, Kamath A, Park S, Chiu H, Lutman J, Maia M, Tan MW, Xu M, Swem L, Deng R Abstract MHAA4549A is a human immunoglobulin G1 (IgG1) monoclonal antibody that binds to a highly conserved epitope on the stalk of influenza A hemagglutinin and blocks the hemagglutinin-mediated membrane fusion in the endosome, neutralizing all known human influenz... περισσότερα »
Managing Minor Ailments; The Public's Preferences for Attributes of Community Pharmacies. A Discrete Choice Experiment.
*Managing Minor Ailments; The Public's Preferences for Attributes of Community Pharmacies. A Discrete Choice Experiment.* PLoS One. 2016;11(3):e0152257 Authors: Porteous T, Ryan M, Bond C, Watson M, Watson V Abstract BACKGROUND: Demand for health services continues to rise. Greater use of community pharmacy services instead of medical services for minor ailments could help relieve pressure on healthcare providers in high-cost settings. Community pharmacies are recognised sources of treatment and advice for people wishing to manage these ailments. However, increasing the public's ... περισσότερα »
Two outbreak sources of influenza A (H7N9) viruses have been established in China.
*Two outbreak sources of influenza A (H7N9) viruses have been established in China.* J Virol. 2016 Mar 30; Authors: Wang D, Yang L, Zhu W, Zhang Y, Zou S, Bo H, Gao R, Dong J, Huang W, Guo J, Li Z, Zhao X, Li X, Xin L, Zhou J, Chen T, Dong L, Wei H, Li X, Liu L, Tang J, Lan Y, Yang J, Shu Y Abstract Due to enzootic infections in poultry and persistent human infections in China, influenza A (H7N9) virus has remained a public health threat. The Yangtze River Delta region, which is located in eastern China, is well-recognized as the original source for H7N9 outbreaks. Based on the ... περισσότερα »
Leukemia cell mobilization with G-CSF plus plerixafor during busulfan-fludarabine conditioning for allogeneic stem cell transplantation.
[image: http:--http://ift.tt/1feGv2I] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Leukemia cell mobilization with G-CSF plus plerixafor during busulfan-fludarabine conditioning for allogeneic stem cell transplantation.* Bone Marrow Transplant. 2015 Jul;50(7):939-46 Authors: Konopleva M, Benton CB, Thall PF, Zeng Z, Shpall E, Ciurea S, Kebriaei P, Alousi A, Popat U, Anderlini P, Nieto Y, Parmar S, Qiao W, Chen J, Rondon G, McMullin B, Wang RY, Lu H, Schober W, Woodworth G, Gulbis A, Cool R, Andreeff M, Champlin R Abstract We hypothesized that during conditioning chemot... περισσότερα »
IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria.* PLoS One. 2014;9(3):e90725 Authors: Hwang KK, Trama AM, Kozink DM, Chen X, Wiehe K, Cooper AJ, Xia SM, Wang M, Marshall DJ, Whitesides J, Alam M, Tomaras GD, Allen SL, Rai KR, McKeating J, Catera R, Yan XJ, Chu CC, Kelsoe G, Liao HX, Chiorazzi N, Haynes BF Abstract B-cell chronic lymphocytic leukemia (B-CLL) patients expressing unmutate... περισσότερα »
[Central serous chorioretinopathy of unusual etiology: A report of 2 cases].
[image: http:--http://ift.tt/1LFUhH3] Related Articles *[Central serous chorioretinopathy of unusual etiology: A report of 2 cases].* Arch Soc Esp Oftalmol. 2014 Jul;89(7):275-8 Authors: Palacios AI, Rodríguez M, Martín MD Abstract OBJECTIVE: Describe 2 rare causes of central serous chorioretinopathy. CLINICAL CASES: Case 1: A 35 year old woman with loss of vision in her left eye, with a recent history of a flu vaccination. This could have been the process that triggered an immune response, with increased circulating immune complexes that favour choroidal ischemia. CASE 2: A 41 ye... περισσότερα »
Tumor Heterogeneity in Lung Cancer: Assessment with Dynamic Contrast-enhanced MR Imaging.
*Tumor Heterogeneity in Lung Cancer: Assessment with Dynamic Contrast-enhanced MR Imaging.* Radiology. 2016 Mar 31;:151367 Authors: Yoon SH, Park CM, Park SJ, Yoon JH, Hahn S, Goo JM Abstract Purpose To evaluate histogram and texture parameters on pretreatment dynamic contrast material-enhanced (DCE) magnetic resonance (MR) images in lung cancer in terms of temporal change, optimal time for analysis, and prognostic potential. Materials and Methods This retrospective study was approved by the institutional review board, and the requirement to obtain informed consent was waived. Th... περισσότερα »
Dataset for Reporting of Malignant Mesothelioma of the Pleura or Peritoneum: Recommendations From the International Collaboration on Cancer Reporting (ICCR).
*Dataset for Reporting of Malignant Mesothelioma of the Pleura or Peritoneum: Recommendations From the International Collaboration on Cancer Reporting (ICCR).* Arch Pathol Lab Med. 2016 Mar 31; Authors: Churg A, Attanoos R, Borczuk AC, Chirieac LR, Galateau-Sallé F, Gibbs A, Henderson D, Roggli V, Rusch V, Judge MJ, Srigley JR Abstract CONTEXT: -The International Collaboration on Cancer Reporting is a not-for-profit organization formed by the Royal Colleges of Pathologists of Australasia and the United Kingdom; the College of American Pathologists; the Canadian Association of Pat... περισσότερα »
Sarcomatoid Urothelial Carcinoma of the Bladder: Analysis of 28 Cases With Emphasis on Clinicopathologic Features and Markers of Epithelial-to-Mesenchymal Transition.
*Sarcomatoid Urothelial Carcinoma of the Bladder: Analysis of 28 Cases With Emphasis on Clinicopathologic Features and Markers of Epithelial-to-Mesenchymal Transition.* Arch Pathol Lab Med. 2016 Mar 31; Authors: Sanfrancesco J, McKenney JK, Leivo MZ, Gupta S, Elson P, Hansel DE Abstract CONTEXT: -Sarcomatoid urothelial carcinoma (UCa) is a rare but aggressive variant of bladder cancer that can show diagnostic challenges even using ancillary techniques. OBJECTIVE: -To examine immunohistochemical markers in the context of sarcomatoid UCa, including those associated with epithelial-t...περισσότερα »
Automated Extraction of Formalin-Fixed, Paraffin-Embedded Tissue for High-Risk Human Papillomavirus Testing of Head and Neck Squamous Cell Carcinomas Using the Roche cobas 4800 System.
*Automated Extraction of Formalin-Fixed, Paraffin-Embedded Tissue for High-Risk Human Papillomavirus Testing of Head and Neck Squamous Cell Carcinomas Using the Roche cobas 4800 System.* Arch Pathol Lab Med. 2016 Mar 31; Authors: Kerr DA, Sweeney B, Arpin RN, Ring M, Pitman MB, Wilbur DC, Faquin WC Abstract CONTEXT: -Testing for high-risk human papillomavirus (HR-HPV) in head and neck squamous cell carcinomas (HNSCCs) is important for both prognostication and clinical management. Several testing platforms are available for HR-HPV; however, effective alternative automated approach... περισσότερα »
"Med Oral Patol Oral Cir Bucal"[jour]; +16 new citations
16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *"Med Oral Patol Oral Cir Bucal"[jour]* These pubmed results were generated on 2016/04/01 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1q8MAU0 via IFTTT
The role of HOXB9 and miR-196a in head and neck squamous cell carcinoma.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *The role of HOXB9 and miR-196a in head and neck squamous cell carcinoma.* PLoS One. 2015;10(4):e0122285 Authors: Darda L, Hakami F, Morgan R, Murdoch C, Lambert DW, Hunter KD Abstract BACKGROUND: Previous studies have demonstrated that a number of HOX genes, a family of transcription factors with key roles in early development, are up-regulated in head and neck squamous cell carcinoma (HNSCC) and other cancers. The loci of several Homeobox (HOX) genes also contain microRNAs (miRs), inclu... περισσότερα »
Dual inhibition of oncogenic targets for B-cell malignancies
[Comment] [image: fx1.sml] Effective treatment options for patients with relapsed and refractory lymphoma and multiple myeloma remain an area of unmet medical need, despite recent advances in both diseases. In The Lancet Oncology, Anas Younes and colleagues1 present the results of a phase 1 safety and dose escalation study of CUDC-907—a first-in-class, oral, dual inhibitor of histone deacetylase (HDAC) and phosphoinositide 3-kinase (PI3K)—in patients with advanced refractory lymphoma and multiple myeloma.2–5 The study was a first-in-man, multicentre trial in which CUDC-907 was ...περισσότερα »
Dataset for Reporting of Malignant Mesothelioma of the Pleura or Peritoneum: Recommendations From the International Collaboration on Cancer Reporting (ICCR).
*Dataset for Reporting of Malignant Mesothelioma of the Pleura or Peritoneum: Recommendations From the International Collaboration on Cancer Reporting (ICCR).* Arch Pathol Lab Med. 2016 Mar 31; Authors: Churg A, Attanoos R, Borczuk AC, Chirieac LR, Galateau-Sallé F, Gibbs A, Henderson D, Roggli V, Rusch V, Judge MJ, Srigley JR Abstract CONTEXT: -The International Collaboration on Cancer Reporting is a not-for-profit organization formed by the Royal Colleges of Pathologists of Australasia and the United Kingdom; the College of American Pathologists; the Canadian Association of Pat... περισσότερα »
Sarcomatoid Urothelial Carcinoma of the Bladder: Analysis of 28 Cases With Emphasis on Clinicopathologic Features and Markers of Epithelial-to-Mesenchymal Transition.
*Sarcomatoid Urothelial Carcinoma of the Bladder: Analysis of 28 Cases With Emphasis on Clinicopathologic Features and Markers of Epithelial-to-Mesenchymal Transition.* Arch Pathol Lab Med. 2016 Mar 31; Authors: Sanfrancesco J, McKenney JK, Leivo MZ, Gupta S, Elson P, Hansel DE Abstract CONTEXT: -Sarcomatoid urothelial carcinoma (UCa) is a rare but aggressive variant of bladder cancer that can show diagnostic challenges even using ancillary techniques. OBJECTIVE: -To examine immunohistochemical markers in the context of sarcomatoid UCa, including those associated with epithelial-t...περισσότερα »
Automated Extraction of Formalin-Fixed, Paraffin-Embedded Tissue for High-Risk Human Papillomavirus Testing of Head and Neck Squamous Cell Carcinomas Using the Roche cobas 4800 System.
*Automated Extraction of Formalin-Fixed, Paraffin-Embedded Tissue for High-Risk Human Papillomavirus Testing of Head and Neck Squamous Cell Carcinomas Using the Roche cobas 4800 System.* Arch Pathol Lab Med. 2016 Mar 31; Authors: Kerr DA, Sweeney B, Arpin RN, Ring M, Pitman MB, Wilbur DC, Faquin WC Abstract CONTEXT: -Testing for high-risk human papillomavirus (HR-HPV) in head and neck squamous cell carcinomas (HNSCCs) is important for both prognostication and clinical management. Several testing platforms are available for HR-HPV; however, effective alternative automated approach... περισσότερα »
Cutaneous HPV 3, 15, 38, and 76 Do Not Cause SCC of the Skin
Cutaneous HPV 3, 15, 38, and 76 Do Not Cause SCC of the Skin: *Background:* Cutaneous human papillomavirus (HPV) types have been associated with non-melanoma skin cancer (NMSC), including a previous nested case–control study using HPV serology with bacterially derived fusion proteins with the major HPV capsid protein L1 (GST-L1). However, HPV serology using conformationally intact pseudovirions has been shown to correlate better with natural infection. Prospective studies using a more valid marker of infection are therefore warranted. *Methods:* Cancer registry follow-up of large N...περισσότερα »
Coffee and the Risk of Colorectal Cancer
Coffee and the Risk of Colorectal Cancer: *Background:* Coffee contains several bioactive compounds relevant to colon physiology. Although coffee intake is a proposed protective factor for colorectal cancer, current evidence remains inconclusive. *Methods:* We investigated the association between coffee consumption and risk of colorectal cancer in 5,145 cases and 4,097 controls from the Molecular Epidemiology of Colorectal Cancer (MECC) study, a population-based case–control study in northern Israel. We also examined this association by type of coffee, by cancer site (colon and rec...περισσότερα »
The Norwegian Voice Handicap Index (VHI-N) patient scores are dependent on voice-related disease group.
[image: http:--production.springer.de-OnlineReso] Related Articles *The Norwegian Voice Handicap Index (VHI-N) patient scores are dependent on voice-related disease group.* Eur Arch Otorhinolaryngol. 2015 Oct;272(10):2897-905 Authors: Karlsen T, Heimdal JH, Grieg AR, Aarstad HJ Abstract The aim of this study is to determine to what extent the Voice Handicap Index-Norwegian (VHI-N) is scored depending on specific laryngological disease. In a multi-center study, 126 healthy subjects and 355 patients with different voice-related diseases answered the VHI-N. The VHI-N scores showed h... περισσότερα »
High prevalence of early language delay exists among toddlers with neonatal brachial plexus palsy.
[image: http:--linkinghub.elsevier.com-ihub-imag] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *High prevalence of early language delay exists among toddlers with neonatal brachial plexus palsy.* Pediatr Neurol. 2014 Sep;51(3):384-9 Authors: Chang KW, Yang LJ, Driver L, Nelson VS Abstract AIM: An association of language impairment with neonatal brachial plexus palsy has not been reported in the literature. The current treatment paradigm for neonatal brachial plexus palsy focuses on upper extremity motor recovery with little formal assessment of other aspects of develop... περισσότερα »
Serum zinc levels in 368 patients with oral mucosal diseases: A preliminary study.
*Serum zinc levels in 368 patients with oral mucosal diseases: A preliminary study.* Med Oral Patol Oral Cir Bucal. 2016 Mar 31;:0 Authors: Bao ZX, Yang XW, Shi J, Liu LX Abstract BACKGROUND: The aim of this study was to assess the serum zinc levels in patients with common oral mucosal diseases by comparing these to healthy controls. MATERIAL AND METHODS: A total of 368 patients, which consisted of 156 recurrent aphthous stomatitis (RAS) patients, 57 oral lichen planus (OLP) patients, 55 burning mouth syndrome (BMS) patients, 54 atrophic glossitis (AG) patients, 46 xerostomia pat...περισσότερα »
Dataset for Reporting of Malignant Mesothelioma of the Pleura or Peritoneum: Recommendations From the International Collaboration on Cancer Reporting (ICCR).
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
*Dataset for Reporting of Malignant Mesothelioma of the Pleura or Peritoneum: Recommendations From the International Collaboration on Cancer Reporting (ICCR).* Arch Pathol Lab Med. 2016 Mar 31; Authors: Churg A, Attanoos R, Borczuk AC, Chirieac LR, Galateau-Sallé F, Gibbs A, Henderson D, Roggli V, Rusch V, Judge MJ, Srigley JR Abstract CONTEXT: -The International Collaboration on Cancer Reporting is a not-for-profit organization formed by the Royal Colleges of Pathologists of Australasia and the United Kingdom; the College of American Pathologists; the Canadian Association of Pat... περισσότερα »
Sarcomatoid Urothelial Carcinoma of the Bladder: Analysis of 28 Cases With Emphasis on Clinicopathologic Features and Markers of Epithelial-to-Mesenchymal Transition.
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
*Sarcomatoid Urothelial Carcinoma of the Bladder: Analysis of 28 Cases With Emphasis on Clinicopathologic Features and Markers of Epithelial-to-Mesenchymal Transition.* Arch Pathol Lab Med. 2016 Mar 31; Authors: Sanfrancesco J, McKenney JK, Leivo MZ, Gupta S, Elson P, Hansel DE Abstract CONTEXT: -Sarcomatoid urothelial carcinoma (UCa) is a rare but aggressive variant of bladder cancer that can show diagnostic challenges even using ancillary techniques. OBJECTIVE: -To examine immunohistochemical markers in the context of sarcomatoid UCa, including those associated with epithelial-t...περισσότερα »
Automated Extraction of Formalin-Fixed, Paraffin-Embedded Tissue for High-Risk Human Papillomavirus Testing of Head and Neck Squamous Cell Carcinomas Using the Roche cobas 4800 System.
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
*Automated Extraction of Formalin-Fixed, Paraffin-Embedded Tissue for High-Risk Human Papillomavirus Testing of Head and Neck Squamous Cell Carcinomas Using the Roche cobas 4800 System.* Arch Pathol Lab Med. 2016 Mar 31; Authors: Kerr DA, Sweeney B, Arpin RN, Ring M, Pitman MB, Wilbur DC, Faquin WC Abstract CONTEXT: -Testing for high-risk human papillomavirus (HR-HPV) in head and neck squamous cell carcinomas (HNSCCs) is important for both prognostication and clinical management. Several testing platforms are available for HR-HPV; however, effective alternative automated approach... περισσότερα »
Meta-analysis of Thyroid Cancer Polymorphisms
Meta-analysis of Thyroid Cancer Polymorphisms: *Background:* Linkage analyses and association studies suggested that inherited genetic variations play a role in the development of differentiated thyroid carcinoma (DTC). *Methods:* We combined the results from a genome-wide association study (GWAS) performed by our group and from published studies on DTC. With a first approach, we evaluated whether a SNP published as associated with the risk of DTC could replicate in our GWAS (using FDR as adjustment for multiple comparisons). With the second approach, meta-analyses were performed ...περισσότερα »
Raw Garlic Consumption and Lung Cancer
Raw Garlic Consumption and Lung Cancer: *Background:* Evidence of anticancer properties of garlic for different cancer sites has been reported previously in *in vitro* and *in vivo* experimental studies but there is limited epidemiologic evidence on the association between garlic and lung cancer. *Methods:* We examined the association between raw garlic consumption and lung cancer in a case–control study conducted between 2005 and 2007 in Taiyuan, China. Epidemiologic data was collected by face-to-face interviews from 399 incident lung cancer cases and 466 healthy controls. We used...περισσότερα »
Statin Use and Liver Cancer
Statin Use and Liver Cancer: *Background:* Limited clinical and epidemiologic data suggest that statins may improve the outcomes of hepatocellular carcinoma (HCC), which has poor prognosis. *Methods:* We identified 1,036 stage I or II HCC patients, diagnosed between 2007 and 2009, through the linked Surveillance, Epidemiology, and End Results (SEER) Program and Medicare claims database. Of these, 363 patients were using statin either at the time of their HCC diagnosis or afterwards. We conducted multivariable Cox regression analysis to estimate the time-dependent effect of statin ...περισσότερα »
Intervention to Increase HPV Vaccination
Intervention to Increase HPV Vaccination: *Background:* Uptake of the human papillomavirus (HPV) vaccine is low in Appalachian Ohio and areas with high cervical cancer rates. *Methods:* We conducted a group-randomized trial among 12 counties in Appalachian Ohio randomized to receive either an HPV vaccine (intervention counties) or influenza vaccine (comparison counties) multilevel intervention (MLI). Parents (*n* = 337) who had a daughter aged 9 to 17 years who had not received the HPV vaccine were recruited from commercial lists. Clinics (*N* = 24) and 119 providers from these cli...περισσότερα »
A GWAS of Cutaneous Squamous Cell Carcinoma
A GWAS of Cutaneous Squamous Cell Carcinoma: *Background:* No GWAS on the risk of cutaneous squamous cell carcinoma (SCC) has been published. We conducted a multistage genome-wide association study (GWAS) to identify novel genetic loci for SCC. *Methods:* The study included 745 SCC cases and 12,805 controls of European descent in the discovery stage and 531 SCC cases and 551 controls of European ancestry in the replication stage. We selected 64 independent loci that showed the most significant associations with SCC in the discovery stage (linkage disequilibrium *r*2 < 0.4) for repl... περισσότερα »
Birth Characteristics and Adult Brain Tumors
Birth Characteristics and Adult Brain Tumors: *Background:* Despite extensive research on the effect of birth size characteristics on childhood brain tumors, very few studies have evaluated the effect of birth size characteristics on the risk of adult brain tumor, and they have provided inconsistent results. *Methods:* All individuals born in Sweden between 1973 and 1995 who were still alive and cancer free at their 15th birthday were included in the study (*n* = 2,032,727). At the end of the study period (December 31, 2010), the study participants were 15 to 37 years old. Incident... περισσότερα »
Can Targeting Stroma Pave the Way to Enhanced Antitumor Immunity and Immunotherapy of Solid Tumors?
Can Targeting Stroma Pave the Way to Enhanced Antitumor Immunity and Immunotherapy of Solid Tumors?: Solid tumors are complex organ-like structures. The potential of normal neighboring cells to contribute to the initiation, progression, and metastasis of epithelial-derived carcinomas has long been appreciated. However, the role of host cells has proven complex. Through multiple local and systemic mechanisms, nontransformed host cells can promote transition from a tumor-resistant to tumor-permissive environment, drive neoplastic transformation of epithelial cells, promote tumor grow... περισσότερα »
Metastatic Melanoma Patients Treated with Nivolumab Who Had Progressed after Ipilimumab
Phase I/II Study of Metastatic Melanoma Patients Treated with Nivolumab Who Had Progressed after Ipilimumab: The checkpoint inhibitor nivolumab is active in patients with metastatic melanoma who have failed ipilimumab. In this phase I/II study, we assessed nivolumab's safety in 92 ipilimumab-refractory patients with unresectable stage III or IV melanoma, including those who experienced grade 3–4 drug-related toxicity to ipilimumab. We report long-term survival, response duration, and biomarkers in these patients after nivolumab treatment (3 mg/kg) every 2 weeks for 24 weeks, then e...περισσότερα »
miR-144 in Diffuse Large B-cell Lymphoma Proliferation and Invasion
A Critical Role of MicroRNAs are endogenous noncoding RNAs that play important roles in a wide variety of biologic processes such as apoptosis, development, aging, and tumorigenesis. The B-cell lymphoma 6 (BCL6) transcriptional repressor has emerged as a critical therapeutic target in diffuse large B-cell lymphomas (DLBCL), but the mechanisms regulating BCL6 are still unclear. In the current study, we screened the microRNA expression profiles in DLBCL specimens and cell lines by qRT-PCR and found that the expression of miR-144 was significantly downregulated in DLBCL tissues and ... περισσότερα »
Combining Epigenetic and Immunotherapy to Combat Cancer
Combining Epigenetic and Immunotherapy to Combat Cancer: The most exciting recent advance for achieving durable management of advanced human cancers is immunotherapy, especially the concept of immune checkpoint blockade. However, with the exception of melanoma, most patients do not respond to immunotherapy alone. A growing body of work has shown that epigenetic drugs, specifically DNA methyltransferase inhibitors, can upregulate immune signaling in epithelial cancer cells through demethylation of endogenous retroviruses and cancer testis antigens. These demethylating agents may indu... περισσότερα »
Notch4 and MET in Melanoma
Notch4 and MET in Melanoma: The effects of Notch signaling are context-dependent and both oncogenic and tumor-suppressive functions have been described. Notch signaling in melanoma is considered oncogenic, but clinical trials testing Notch inhibition in this malignancy have not proved successful. Here, we report that expression of the constitutively active intracellular domain of Notch4 (N4ICD) in melanoma cells triggered a switch from a mesenchymal-like parental phenotype to an epithelial-like phenotype. The epithelial-like morphology was accompanied by strongly reduced invasive, m...περισσότερα »
Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses.
*Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses.* J Phys Chem A. 2016 Mar 31; Authors: Banerji B, Chatterjee M, Pal U, Maiti NC Abstract Acetate anion plays an important role in several biochemical functions such as enzyme reaction, antibody response and action of receptor molecules. This investigation reports the synthesis and molecular details of a unique receptor, 2-Amino-N-(2-amino-benzyl)-benzamide (R) that senses selectively acetate via simultaneous involvement of one aromatic amine group and an amide proton of the receptor molecule...περισσότερα »
Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses.
*Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses.* J Phys Chem A. 2016 Mar 31; Authors: Banerji B, Chatterjee M, Pal U, Maiti NC Abstract Acetate anion plays an important role in several biochemical functions such as enzyme reaction, antibody response and action of receptor molecules. This investigation reports the synthesis and molecular details of a unique receptor, 2-Amino-N-(2-amino-benzyl)-benzamide (R) that senses selectively acetate via simultaneous involvement of one aromatic amine group and an amide proton of the receptor molecule...περισσότερα »
Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses.
*Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses.* J Phys Chem A. 2016 Mar 31; Authors: Banerji B, Chatterjee M, Pal U, Maiti NC Abstract Acetate anion plays an important role in several biochemical functions such as enzyme reaction, antibody response and action of receptor molecules. This investigation reports the synthesis and molecular details of a unique receptor, 2-Amino-N-(2-amino-benzyl)-benzamide (R) that senses selectively acetate via simultaneous involvement of one aromatic amine group and an amide proton of the receptor molecule...περισσότερα »
Exosomal miR-21 Mediates Hypoxia-Induced Cell Invasiveness
Exosomal miR-21 Mediates Hypoxia-Induced Cell Invasiveness: Hypoxia is a common feature of solid tumors and is associated with aggressiveness and poor patient outcomes. Exosomes, initially considered to be cellular “garbage dumpsters,” are now implicated in mediating interactions with the cellular environment. However, the mechanisms underlying the association between exosomes and hypoxia during cancer progression remain poorly understood. In this study, we found that exosomes derived from hypoxic oral squamous cell carcinoma (OSCC) cells increased the migration and invasion of OSCC... περισσότερα »
Somatic Alterations in Esophageal and Gastric Cancer
Somatic Alterations in Esophageal and Gastric Cancer: Gastric cancer and esophageal cancer are the second and sixth leading causes of cancer-related death worldwide. Multiple genomic alterations underlying gastric cancer and esophageal squamous cell carcinoma (ESCC) have been identified, but the full spectrum of genomic structural variations and mutations have yet to be uncovered. Here, we report the results of whole-genome sequencing of 30 samples comprising tumor and blood from 15 patients, four of whom presented with ESCC, seven with gastric cardia adenocarcinoma (GCA), and four w...περισσότερα »
Adoptive transfer of osteoclast-expanded natural killer cells for immunotherapy targeting cancer stem-like cells in humanized mice
Adoptive transfer of osteoclast-expanded natural killer cells for immunotherapy targeting cancer stem-like cells in humanized mice: AbstractBased on data obtained from oral, pancreatic and lung cancers, glioblastoma, and melanoma, we have established that natural killer (NK) cells target cancer stem-like cells (CSCs). CSCs displaying low MHC class I, CD54, and PD-L1 are killed by cytotoxic NK cells and are differentiated by split anergized NK cells through both membrane bound and secreted forms of TNF-α and IFN-γ. NK cells select and differentiate both healthy and transformed stem-... περισσότερα »
Lupeol Suppresses Cisplatin-Induced Nuclear Factor-{kappa}B Activation in Head and Neck Squamous Cell Carcinoma and Inhibits Local Invasion and Nodal Metastasis in an Orthotopic Nude Mouse Model
Correction: Lupeol Suppresses Cisplatin-Induced Nuclear Factor-{kappa}B Activation in Head and Neck Squamous Cell Carcinoma and Inhibits Local Invasion and Nodal Metastasis in an Orthotopic Nude Mouse Model: Next Section In this article (Cancer Res 2007;67:8800–9), which appeared in the September 15, 2007 issue of *Cancer Research* (1), there are errors in Figs. 2C and 5B; incorrect gel images belonging to a different experiment were inadvertently used. The affected data are total p65 and total p50 in Fig. 2C and α-SMA in Fig. 5B for CAL27 cells. The data shown for MDA1986 cel... περισσότερα »
T follicular helper cells, T follicular regulatory cells and autoimmunity
T follicular helper cells, T follicular regulatory cells and autoimmunity: CD4+ T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity. Tfh cell differentiation depends on various factors including cell-surface molecule interactions, extracellular cytokines and multiple transcription factors, with B-cell lymphoma 6 (Bcl-6) being the master regulator. T follicular regulatory (Tfr) ce... περισσότερα »
Toxins, Vol. 8, Pages 96: Mechanisms that Determine the Differential Stability of Stx+ and Stx− Lysogens
Phages 933W, BAA2326, 434, and λ are evolutionarily-related temperate lambdoid phages that infect Escherichia coli. Although these are highly-similar phages, BAA2326 and 933W naturally encode Shiga toxin 2 (Stx+), but phage 434 and λ do not (Stx−). Previous reports suggest that the 933W Stx+ prophage forms less stable lysogens in E. coli than does the… Continue reading Toxins, Vol. 8, Pages 96: Mechanisms that Determine the Differential Stability of Stx+ and Stx− Lysogens
LORAKS makes better SENSE: Phase-constrained partial fourier SENSE reconstruction without phase calibration
Purpose Parallel imaging and partial Fourier acquisition are two classical approaches for accelerated MRI. Methods that combine these approaches often rely on prior knowledge of the image phase, but the need to obtain this prior information can place practical restrictions on the data acquisition strategy. In this work, we propose and evaluate SENSE-LORAKS, which enables… Continue reading LORAKS makes better SENSE: Phase-constrained partial fourier SENSE reconstruction without phase calibration
MR fingerprinting for rapid quantification of myocardial T1, T2, and proton spin density
Purpose To introduce a two-dimensional MR fingerprinting (MRF) technique for quantification of T1, T2, and M0 in myocardium. Methods An electrocardiograph-triggered MRF method is introduced for mapping myocardial T1, T2, and M0 during a single breath-hold in as short as four heartbeats. The pulse sequence uses variable flip angles, repetition times, inversion recovery times, and… Continue reading MR fingerprinting for rapid quantification of myocardial T1, T2, and proton spin density
Hexagonal gradient scheme with RF spoiling improves spoiling performance for high-flip-angle fast gradient echo imaging
Purpose To present a framework in which time-varying gradients are applied with RF spoiling to reduce unwanted signal, particularly at high flip angles. Methods A time-varying gradient spoiler scheme compatible with RF spoiling is defined, in which spoiler gradients cycle through the vertices of a hexagon, which we call hexagonal spoiling. The method is compared… Continue reading Hexagonal gradient scheme with RF spoiling improves spoiling performance for high-flip-angle fast gradient echo imaging
18 FFE@SNAP—a specific PET tracer for melanin-concentrating hormone receptor 1 imaging?
Abstract Background The melanin-concentrating hormone receptor 1 (MCHR1), which is highly expressed in the lateral hypothalamus, plays a key role in energy homeostasis, obesity and other endocrine diseases. Hence, there is a major interest in in vivo imaging of this receptor. A PET tracer would allow non-invasive in vivo visualization and quantification of the MCHR1.… Continue reading 18 FFE@SNAP—a specific PET tracer for melanin-concentrating hormone receptor 1 imaging?
Brain appears to have different mechanisms for reconciling sight and sound
A new UCLA psychology study provides insights into how the brain combines sound and vision. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1VXCiC6 via IFTTT
Doctor, can I desensitize my food-allergic child using directly the allergenic molecules?.
Purpose of review: Food allergy has risen in prevalence worldwide and is one of the main causes of anaphylaxis, especially in children. The only possible therapeutic approach is specific immunotherapy. This review describes the recent approaches using allergenic molecules for specific immunotherapy. Recent findings: Hypoallergenic tropomyosins from Metapenaeus ensis have been cloned and constructed by… Continue reading Doctor, can I desensitize my food-allergic child using directly the allergenic molecules?.
Registries as useful tools in characterization of allergic manifestations.
Purpose of review: Registries are useful to discover the applicability of data generated from randomized clinical trials (RCTs) into daily practice, and to search for real-life data usually not covered by them. Recent findings: In allergy, registry research brought clues to important epidemiological and clinical problems hardly accessible with other methods. The increase in the… Continue reading Registries as useful tools in characterization of allergic manifestations.
Hammer sound elicited tinnitus in car body repair worker cured by stapedial tenotomy – A case report
Publication date: Available online 31 March 2016 Source:Auris Nasus Larynx Author(s): Ryoukichi Ikeda, Hiroshi Hidaka, Hiromitsu Miyazaki, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi Abnormal auditory sensations or tinnitus caused by abnormal middle ear muscle contraction are extremely rare and uncomfortable for patients. A 67-year-old man who performed paint and body work for cars presented at… Continue reading Hammer sound elicited tinnitus in car body repair worker cured by stapedial tenotomy – A case report
Hammer sound elicited tinnitus in car body repair worker cured by stapedial tenotomy – A case report
Publication date: Available online 31 March 2016 Source:Auris Nasus Larynx Author(s): Ryoukichi Ikeda, Hiroshi Hidaka, Hiromitsu Miyazaki, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi Abnormal auditory sensations or tinnitus caused by abnormal middle ear muscle contraction are extremely rare and uncomfortable for patients. A 67-year-old man who performed paint and body work for cars presented at… Continue reading Hammer sound elicited tinnitus in car body repair worker cured by stapedial tenotomy – A case report
upper respiratory tract infection; +31 new citations
31 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2016/04/01 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1Tnmlo4 via IFTTT
Fuchs syndrome or erythema multiforme major, uncommon or underdiagnosed?
[image: http:--http://ift.tt/1RtpDVA] Related Articles *Fuchs syndrome or erythema multiforme major, uncommon or underdiagnosed?* Indian J Dermatol Venereol Leprol. 2015 Jul-Aug;81(4):403-5 Authors: Mangal S, Narang T, Saikia UN, Kumaran MS PMID: 26087085 [PubMed - indexed for MEDLINE] from #ORL via xlomafota13 on Inoreader http://ift.tt/1MZ7Xfh via IFTTT
Identification of Stevens-Johnson syndrome and toxic epidermal necrolysis in electronic health record databases.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Identification of Stevens-Johnson syndrome and toxic epidermal necrolysis in electronic health record databases.* Pharmacoepidemiol Drug Saf. 2015 Jul;24(7):684-92 Authors: Davis RL, Gallagher MA, Asgari MM, Eide MJ, Margolis DJ, Macy E, Burmester JK, Selvam N, Boscarino JA, Cromwell LF, Feigelson HS, Kuntz JL, Pawloski PA, Penfold RB, Raebel MA, Sridhar G, Wu A, La Grenade LA, Pacanowski MA, Pinheiro SP Abstract BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) carry a high mortalit... περισσότερα »
Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses.
*Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses.* J Phys Chem A. 2016 Mar 31; Authors: Banerji B, Chatterjee M, Pal U, Maiti NC Abstract Acetate anion plays an important role in several biochemical functions such as enzyme reaction, antibody response and action of receptor molecules. This investigation reports the synthesis and molecular details of a unique receptor, 2-Amino-N-(2-amino-benzyl)-benzamide (R) that senses selectively acetate via simultaneous involvement of one aromatic amine group and an amide proton of the receptor molecule...περισσότερα »
Stable Voice Clusters Identified When Using the Maximum versus Minimum Intensity Curve in the Phonetogram.
*Stable Voice Clusters Identified When Using the Maximum versus Minimum Intensity Curve in the Phonetogram.* Folia Phoniatr Logop. 2016 Apr 1;67(5):259-266 Authors: Camarrone F, Ivanova A, Decoster W, de Jong F, van Hulle MM Abstract OBJECTIVE: To examine whether the minimum as well as the maximum voice intensity (i.e. sound pressure level, SPL) curves of a voice range profile (VRP) are required when discovering different voice groups based on a clustering analysis. In this approach, no a priori labeling of voice types is used. PATIENTS AND METHODS: VRPs of 194 (84 male and 110 fe...περισσότερα »
Organizational uncertainty and stress among teachers in Hong Kong: work characteristics and organizational justice.
*Organizational uncertainty and stress among teachers in Hong Kong: work characteristics and organizational justice.* Health Promot Int. 2016 Mar 30; Authors: Hassard J, Teoh K, Cox T Abstract A growing literature now exists examining the relationship between organizational justice and employees' experience of stress. Despite the growth in this field of enquiry, there remain continued gaps in knowledge. In particular, the contribution of perceptions of justice to employees' stress within an organizational context of uncertainty and change, and in relation to the new and emerging ... περισσότερα »
Stable Voice Clusters Identified When Using the Maximum versus Minimum Intensity Curve in the Phonetogram.
*Stable Voice Clusters Identified When Using the Maximum versus Minimum Intensity Curve in the Phonetogram.* Folia Phoniatr Logop. 2016 Apr 1;67(5):259-266 Authors: Camarrone F, Ivanova A, Decoster W, de Jong F, van Hulle MM Abstract OBJECTIVE: To examine whether the minimum as well as the maximum voice intensity (i.e. sound pressure level, SPL) curves of a voice range profile (VRP) are required when discovering different voice groups based on a clustering analysis. In this approach, no a priori labeling of voice types is used. PATIENTS AND METHODS: VRPs of 194 (84 male and 110 fe...περισσότερα »
Organizational uncertainty and stress among teachers in Hong Kong: work characteristics and organizational justice.
*Organizational uncertainty and stress among teachers in Hong Kong: work characteristics and organizational justice.* Health Promot Int. 2016 Mar 30; Authors: Hassard J, Teoh K, Cox T Abstract A growing literature now exists examining the relationship between organizational justice and employees' experience of stress. Despite the growth in this field of enquiry, there remain continued gaps in knowledge. In particular, the contribution of perceptions of justice to employees' stress within an organizational context of uncertainty and change, and in relation to the new and emerging ... περισσότερα »
Preconceptional exposure to oral contraceptive pills
and the risk of wheeze, asthma and rhinitis in children via Allergology International Publication date: Available online 30 March 2016 *Source:*Allergology International Author(s): Kiwako Yamamoto-Hanada, Masaki Futamura, Limin Yang, Tetsuo Shoda, Masami Narita, Fumio Kobayashi, Hirohisa Saito, Yukihiro Ohya BackgroundThe prevalence of maternal oral contraceptive pills (OCP) use and that of childhood asthma are high in western countries. The aim of this study is to examine the association of OCP use with childhood wheeze and allergic diseases in Japan.MethodsRelevant data were extracte... περισσότερα »
Registries as useful tools in characterization of allergic manifestations.
Registries as useful tools in characterization of allergic manifestations.: Purpose of review: Registries are useful to discover the applicability of data generated from randomized clinical trials (RCTs) into daily practice, and to search for real-life data usually not covered by them. Recent findings: In allergy, registry research brought clues to important epidemiological and clinical problems hardly accessible with other methods. The increase in the asthma prevalence in Sweden in contrast with stabilization in Denmark; the association of the prevalence of asthma and environmental... περισσότερα »
Doctor, can I desensitize my food-allergic child using directly the allergenic molecules?.
Doctor, can I desensitize my food-allergic child using directly the allergenic molecules?.: Purpose of review: Food allergy has risen in prevalence worldwide and is one of the main causes of anaphylaxis, especially in children. The only possible therapeutic approach is specific immunotherapy. This review describes the recent approaches using allergenic molecules for specific immunotherapy. Recent findings: Hypoallergenic tropomyosins from Metapenaeus ensis have been cloned and constructed by direct mutagenesis or epitope deletion and have been successfully used in shrimp-sensitized ...περισσότερα »
Frequency of bone graft in implant surgery
Frequency of bone graft in implant surgery: Abstract BackgroundImplant surgery has become popular with the advance of surgical techniques such as sinus lifting, guided bone regeneration, and block bone graft. However, there were no data about the frequency of bone graft during implant surgery. The purpose of this study was to report the frequency and types of bone graft depending on dental implant patients’ profile to complement the database regarding implant surgery. MethodsThe implant operations had been performed from January 2006 to October 2014. The upper and lower jaws we... περισσότερα »
The effect of orthognathic surgery on the lip lines while smiling in skeletal class III patients with facial asymmetry
The effect of orthognathic surgery on the lip lines while smiling in skeletal class III patients with facial asymmetry: Abstract BackgroundThe aim of this study was to examine the relationship between improvements in lip asymmetry at rest and while smiling after orthognathic surgery in patients with skeletal class III malocclusion. MethodsThis study included 21 patients with skeletal class III malocclusion and facial asymmetry. We used preoperative and postoperative CT data and photographs to measure the vertical distance of the lips when smiling. The photographs were calibrate... περισσότερα »
Sentinel node biopsy in oral cancer treatment
The patients’ perspective on the impact of via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 31 March 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Géke B. Flach, Irma M. Verdonck-de Leeuw, Birgit I. Witte, W. Martin C. Klop, Robert J.J. van Es, Kees-Pieter Schepman, Remco de Bree IntroductionAssessment of the impact of a SNB-based strategy in cT1/T2N0 oral cancer on the course of health related quality of life, psychological distress and shoulder disability. And evaluation of the patients’ pe... περισσότερα »
Waardenburg syndrome type I: Dental phenotypes and genetic analysis of an extended family.
*Waardenburg syndrome type I: Dental phenotypes and genetic analysis of an extended family.* Med Oral Patol Oral Cir Bucal. 2016 Mar 31;:0 Authors: Sólia-Nasser L, de Aquino SN, Paranaíba LR, Gomes A, Dos-Santos-Neto P, Coletta RD, Cardoso AF, Frota AC, Martelli-Júnior H Abstract BACKGROUND: The aim of this study was to describe the pattern of inheritance and the clinical features in a large family with Waardenburg syndrome type I (WS1), detailing the dental abnormalities and screening for PAX3 mutations. MATERIAL AND METHODS: To characterize the pattern of inheritance and clinic... περισσότερα »
Putative digenic inheritance of heterozygous RP1L1 and C2orf71 null mutations in syndromic retinal dystrophy.
*Putative digenic inheritance of heterozygous RP1L1 and C2orf71 null mutations in syndromic retinal dystrophy.* Ophthalmic Genet. 2016 Mar 30;:1-6 Authors: Liu YP, Bosch DG, Siemiatkowska AM, Rendtorff ND, Boonstra FN, Möller C, Tranebjærg L, Katsanis N, Cremers FP Abstract BACKGROUND: Retinitis pigmentosa (RP) is the most common cause of inherited retinal degeneration and can occur in non-syndromic and syndromic forms. Syndromic RP is accompanied by other symptoms such as intellectual disability, hearing loss, or congenital abnormalities. Both forms are known to exhibit complex ... περισσότερα »
Atherosclerosis’ signs within the segments of internal carotid artery
Severity and presence of atherosclerosis’ signs within the segments of internal carotid artery: The CBCT’s contribution via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 31 March 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Spyros Damaskos, Heraldo L.D. da Silveira, Erwin W.R. Berkhout ObjectivesThis study aims to assess the distribution and interrelation of the presence of calcifications along the course of the internal carotid artery (ICA), by cone beam CT (CBCT), and to associate the severit...περισσότερα »
MicroRNAs in Oral lichen Planus and potential miRNA-mRNA pathogenesis with essential cytokines
: A Review via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 31 March 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Hui Ma, Yuanqin Wu, Huamei Yang, Jiajia Liu, Hongxia Dan, Xin Zeng, Yu Zhou, Lu Jiang, Qianming Chen Oral lichen planus (OLP) is a potentially premalignant condition with an unknown pathogenesis. Immune and inflammatory factors are thought to play important roles in the development of OLP, and cytokines, such as interferon (IFN)-γ and tumor necrosis factor (TNF)-α, can act as crit...περισσότερα »
Oral-Antral Fistulae Resulting from Medication-Related Osteonecrosis of the Maxilla : The Treatment
A Technique for the Treatment of Oral-Antral Fistulae Resulting from Medication-Related Osteonecrosis of the Maxilla: The Combined Buccal Fat Pad Flap and Radical Sinusotomy via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 31 March 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): James C. Melville, Ramzey Tursun, Jonathan W. Shum, Simon Young, Issa A. Hanna, Robert E. Marx ObjectiveBisphosphonates and monoclonal antibodies directed at osteoclastic function are frequently used to treat postmenopau... περισσότερα »
Mandibular Reconstruction Using a Custom-Made Titanium Prosthesis: A Case Report on the Use of Virtual Surgical Planning and Computer-Aided Design/Computer-Aided Manufacturing
Mandibular Reconstruction Using a Custom-Made Titanium Prosthesis: A Case Report on the Use of Virtual Surgical Planning and Computer-Aided Design/Computer-Aided Manufacturing: Cranial Maxillofac Trauma Reconstruction DOI: 10.1055/s-0036-1581060 The use of virtual surgical planning and computer-aided design/computer-aided manufacturing has been reported to enhance the planning for the reconstruction of mandibular continuity defects. This case report illustrates the use of this technology in the fabrication of a custom-made titanium prosthesis to restore a segmental mandibular defe...περισσότερα »
Management of Mandibular Angle Fractures
: Single Stainless Steel Linear Miniplate Versus Rectangular Grid Plate—A Prospective Randomised Study: Abstract PurposeThis prospective study was conducted to evaluate the efficacy of stainless steel single linear miniplate with rectangular grid plate in the treatment of mandibular angle fractures. MethodsThis study included 30 patients who were allocated randomly into two groups of each. Group 1 patients were treated with single 2 mm × 4 hole linear stainless steel miniplate and group 2 patients with 2 mm × 4 hole rectangular grid plate. Patients were evaluated for fracture st...περισσότερα »
The pathogenesis of odontogenic tumors
Molecular Signaling in Benign Odontogenic Neoplasia Pathogenesis: AbstractSeveral molecular pathways have been shown to play critical roles in the pathogenesis of odontogenic tumors. These neoplasms arise from the epithelial or mesenchymal cells of the dental apparatus in the jaw or oral mucosa. Next-generation genomic sequencing has identified gene mutations or single nucleotide polymorphisms associated with many of these tumors. In this review, we focus on two of the most common odontogenic tumor subtypes: ameloblastoma and keratocystic odontogenic tumors. We highlight gene expre...περισσότερα »
Treating Life-Threatening Myocarditis by Blocking Interleukin-1.
[image: wk-health-logo.gif] Objective: Treatment of viral fulminant myocarditis relies on life support measures. Based on studies pointing to a role for the proinflammatory cytokine interleukin-1 in myocardial inflammation and contractile dysfunction, we treated a patient with fulminant viral myocarditis with the interleukin-1 receptor blocking agent anakinra. We report the response and discuss the biologic rationale of this novel treatment approach. Design: Case report. Setting: ICU. Patient: A 36-year-old woman who was hospitalized for fulminant myocarditis with biventricular fai... περισσότερα »
Delayed Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Inhibition by Trametinib Attenuates Systemic Inflammatory Responses and Multiple Organ Injury in Murine Sepsis.
[image: wk-health-logo.gif] Objective: The mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway is an essential component of innate immunity necessary for mediating proinflammatory responses in the setting of sepsis. We previously demonstrated that the mitogen-activated protein kinase 1/2 inhibitor trametinib prevents endotoxin-induced renal injury in mice. We therefore assessed efficacy of trametinib in a more clinically relevant experimental model of sepsis. Design: Controlled in vivo laboratory study. Setting: University animal research labora... περισσότερα »
Derivation of Novel Risk Prediction Scores for Community-Acquired Sepsis and Severe Sepsis.
[image: wk-health-logo.gif] Objective: We sought to derive and internally validate a Sepsis Risk Score and a Severe Sepsis Risk Score predicting future sepsis and severe sepsis events among community-dwelling adults. Design: National population-based cohort. Setting: United States. Subjects: A total of 30,239 community-dwelling adults 45 years old or older in the national REasons for Geographic And Racial Differences in Stroke cohort. Interventions: None. Measurements and Main Results: Over a median of 6.6 years (interquartile range, 5.1-8.1 yr) of follow-up, there were 1,532 first... περισσότερα »
Hospital Variation in Early Tracheostomy in the United States: A Population-Based Study.
[image: wk-health-logo.gif] Objective: Controversy exists regarding perceived benefits of early tracheostomy to facilitate weaning among mechanically ventilated patients, potentially leading to significant practice-pattern variation with implications for outcomes and resource utilization. We sought to determine practice-pattern variation and outcomes associated with tracheostomy timing in the United States. Design: In a retrospective cohort study, we identified mechanically ventilated patients with the most common causes of respiratory failure leading to tracheostomy: pneumonia/sep... περισσότερα »
Curriculum Development and Evaluation of a Hemodynamic Critical Care Ultrasound: A Systematic Review of the Literature.
[image: wk-health-logo.gif] Objective: The application of ultrasound to assess a patient's cardiac function and volume status is becoming commonplace in the practice of critical care. These skills have been taught through varying curricula; however, no consensus on the optimal curriculum has been established. The purpose of this systematic review is to evaluate the literature regarding critical care ultrasound curriculum development and evaluation. Data Sources: Studies were identified using MEDLINE, Embase, CINAHL, PsycInfo, the Cochrane Center Register of Controlled Trials, and E... περισσότερα »
Functional Outcomes and Physical Impairments in Pediatric Critical Care Survivors: A Scoping Review.
Objective: Although more children are surviving critical illness, little is known about long-term physical impairment. This scoping review aims to critically appraise existing literature on functional outcome measurement tools, prevalence, and risk factors for physical impairments in pediatric critical care survivors. Data Sources: PubMed, Embase, and Cumulative Index to Nursing and Allied Health Literature, using a combination of MeSH terms and keywords (critical illness, intensive care, and functional outcomes/status). Study Selection: All human studies reporting functional outcom... περισσότερα »
Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses.
*Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses.* J Phys Chem A. 2016 Mar 31; Authors: Banerji B, Chatterjee M, Pal U, Maiti NC Abstract Acetate anion plays an important role in several biochemical functions such as enzyme reaction, antibody response and action of receptor molecules. This investigation reports the synthesis and molecular details of a unique receptor, 2-Amino-N-(2-amino-benzyl)-benzamide (R) that senses selectively acetate via simultaneous involvement of one aromatic amine group and an amide proton of the receptor molecule...περισσότερα »
Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses.
*Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses.* J Phys Chem A. 2016 Mar 31; Authors: Banerji B, Chatterjee M, Pal U, Maiti NC Abstract Acetate anion plays an important role in several biochemical functions such as enzyme reaction, antibody response and action of receptor molecules. This investigation reports the synthesis and molecular details of a unique receptor, 2-Amino-N-(2-amino-benzyl)-benzamide (R) that senses selectively acetate via simultaneous involvement of one aromatic amine group and an amide proton of the receptor molecule...περισσότερα »
Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses.
*Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses.* J Phys Chem A. 2016 Mar 31; Authors: Banerji B, Chatterjee M, Pal U, Maiti NC Abstract Acetate anion plays an important role in several biochemical functions such as enzyme reaction, antibody response and action of receptor molecules. This investigation reports the synthesis and molecular details of a unique receptor, 2-Amino-N-(2-amino-benzyl)-benzamide (R) that senses selectively acetate via simultaneous involvement of one aromatic amine group and an amide proton of the receptor molecule...περισσότερα »
Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses.
*Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses.* J Phys Chem A. 2016 Mar 31; Authors: Banerji B, Chatterjee M, Pal U, Maiti NC Abstract Acetate anion plays an important role in several biochemical functions such as enzyme reaction, antibody response and action of receptor molecules. This investigation reports the synthesis and molecular details of a unique receptor, 2-Amino-N-(2-amino-benzyl)-benzamide (R) that senses selectively acetate via simultaneous involvement of one aromatic amine group and an amide proton of the receptor molecule...περισσότερα »
Amelioratory effect of flavonoids rich Pergularia daemia extract against CFA induced arthritic rats
Publication date: May 2016 *Source:*Biomedicine & Pharmacotherapy, Volume 80 Author(s): Devanesan Arul Ananth, Angappan Rameshkumar, Ramachandran Jeyadevi, G. Smilin Bell Aseervatham, Jaganathan Sripriya, Prabaharan Chandra Bose, Thilagar Sivasudha PurposePergularia daemia Forsk. (Asclepiadaceae) is a traditionally reported medicinal herb used to treat joint pain and arthritis. However, there are no scientific reports about anti-arthritic activity of P. daemia methanolic extract on rats as animal model. This study identifies bioactive compounds present in the P. daemia methanolic ex...περισσότερα »
Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene.
Introduction: Mutations in the butyrylcholinesterase enzyme (BChE) can result in prolonged duration of action of the neuromuscular blocking agents, succinylcholine and mivacurium, as BChE hydrolyses these drugs. Hereditary low BChE activity can cause extensively prolonged apnoea during general anaesthesia when these drugs are used. The aim of this study was to describe novel mutations in the butyrylcholinesterase gene (BCHE) in patients who have experienced prolonged duration of action of mivacurium or succinylcholine. Methods: The Danish Cholinesterase Research Unit registers patie... περισσότερα »
Vedolizumab induction therapy for inflammatory bowel disease in clinical practice – a nationwide consecutive German cohort study
[image: cover.gif?v=1&s=1210a762d0eea1d55ad4e0b0] Summary Background Vedolizumab (VDZ) is a humanised monoclonal IgG1 antibody targeting α4β7 integrin. Aim To investigate the real-world efficacy of vedolizumab for the treatment of Crohn's disease (CD) and ulcerative colitis (UC). Methods A consecutive cohort of 212 adult IBD patients with active disease (HBI >7/partial Mayo >4) newly receiving VDZ was prospectively recruited from 7 academic and 17 community centres. The primary endpoint was clinical remission (CRM) (CD HBI ≤4, UC pMayo ≤1) in week 14. Secondary endpoints incl... περισσότερα »
Tumor Heterogeneity in Lung Cancer: Assessment with Dynamic Contrast-enhanced MR Imaging.
*Tumor Heterogeneity in Lung Cancer: Assessment with Dynamic Contrast-enhanced MR Imaging.* Radiology. 2016 Mar 31;:151367 Authors: Yoon SH, Park CM, Park SJ, Yoon JH, Hahn S, Goo JM Abstract Purpose To evaluate histogram and texture parameters on pretreatment dynamic contrast material-enhanced (DCE) magnetic resonance (MR) images in lung cancer in terms of temporal change, optimal time for analysis, and prognostic potential. Materials and Methods This retrospective study was approved by the institutional review board, and the requirement to obtain informed consent was waived. Th... περισσότερα »
The role of HOXB9 and miR-196a in head and neck squamous cell carcinoma.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *The role of HOXB9 and miR-196a in head and neck squamous cell carcinoma.* PLoS One. 2015;10(4):e0122285 Authors: Darda L, Hakami F, Morgan R, Murdoch C, Lambert DW, Hunter KD Abstract BACKGROUND: Previous studies have demonstrated that a number of HOX genes, a family of transcription factors with key roles in early development, are up-regulated in head and neck squamous cell carcinoma (HNSCC) and other cancers. The loci of several Homeobox (HOX) genes also contain microRNAs (miRs), inclu... περισσότερα »
Meta-analysis of the effectiveness of esomeprazole in gastroesophageal reflux disease and Helicobacter pylori infection.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Meta-analysis of the effectiveness of esomeprazole in gastroesophageal reflux disease and Helicobacter pylori infection.* J Clin Pharm Ther. 2015 Aug;40(4):368-75 Authors: Teng M, Khoo AL, Zhao YJ, Lin L, Lim BP, Wu TS, Dan YY Abstract WHAT IS KNOWN AND OBJECTIVE: Proton pump inhibitors (PPIs) are one of the most widely used classes of drugs. However, the quantum clinical benefit of newer and more expensive PPIs over the older generation PPIs remains uncertain. This meta-analysis sought to assess the clinical and ... περισσότερα »
Correlation between hypersensitivity induced by esophageal acid infusion and the baseline impedance level in patients with suspected gastroesophageal reflux.
[image: http:--production.springer.de-OnlineReso] Related Articles *Correlation between hypersensitivity induced by esophageal acid infusion and the baseline impedance level in patients with suspected gastroesophageal reflux.* J Gastroenterol. 2015 Jul;50(7):735-43 Authors: Seo AY, Shin CM, Kim N, Yoon H, Park YS, Lee DH Abstract OBJECTIVES: To evaluate the relevance between the pH parameters and baseline impedance level or esophageal hypomotility in patients with suspected gastroesophageal reflux. METHOD: The recordings of 51 patients with heartburn, acid regurgitation, globus o... περισσότερα »
The utility of endoscopy and multichannel intraluminal impedance testing in children with cough and wheezing.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *The utility of endoscopy and multichannel intraluminal impedance testing in children with cough and wheezing.* Pediatr Pulmonol. 2014 Nov;49(11):1090-6 Authors: Rosen R, Amirault J, Johnston N, Haver K, Khatwa U, Rubinstein E, Nurko S Abstract BACKGROUND: Gastroesophageal reflux (GER) has been implicated as a causal factor in respiratory disease but prior studies have focused on the role of acid alone in the genesis of symptoms. Prior studies have relied on pH probe testing but this is blind to non-acid reflux wh... περισσότερα »
Cardiac autonomic dysfunction in patients with gastroesophageal reflux disease.
[image: http:--http://ift.tt/1YyhL4R] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Cardiac autonomic dysfunction in patients with gastroesophageal reflux disease.* World J Gastroenterol. 2015 Jun 14;21(22):6982-9 Authors: Milovanovic B, Filipovic B, Mutavdzin S, Zdravkovic M, Gligorijevic T, Paunovic J, Arsic M Abstract AIM: To investigate autonomic nervous function in patients with a diagnosis of gastroesophageal reflux disease (GERD). METHODS: The investigation was performed on 29 patients (14 men), aged 18-80 years (51.14 ± 18.34), who were referred to our Neurocardi... περισσότερα »
Esomeprazole regimens for reflux symptoms in Chinese patients with chronic gastritis.
[image: http:--http://ift.tt/1YyhL4R] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Esomeprazole regimens for reflux symptoms in Chinese patients with chronic gastritis.* World J Gastroenterol. 2015 Jun 14;21(22):6965-73 Authors: Sun J, Yuan YZ, Hou XH, Zou DW, Lu B, Chen MH, Liu F, Wu KC, Zou XP, Li YQ, Zhou LY Abstract AIM: To compare symptom control with esomeprazole regimens for non-erosive reflux disease and chronic gastritis in patients with a negative endoscopy. METHODS: This randomized, open-label study was designed in line with clinical practice in China. Patien... περισσότερα »
The Role of Gastroesophageal Reflux and Other Factors during Progression to Esophageal Adenocarcinoma.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *The Role of Gastroesophageal Reflux and Other Factors during Progression to Esophageal Adenocarcinoma.* Cancer Epidemiol Biomarkers Prev. 2015 Jul;24(7):1012-23 Authors: Hazelton WD, Curtius K, Inadomi JM, Vaughan TL, Meza R, Rubenstein JH, Hur C, Luebeck EG Abstract BACKGROUND: U.S. esophageal adenocarcinoma (EAC) incidence increased over 5-fold between 1975 and 2009. Symptomatic gastroesophageal reflux disease (sGERD) elevates the risk for EAC. However, a simple calculation suggests that changes in sGERD prevale... περισσότερα »
Meta-analysis of the effectiveness of esomeprazole in gastroesophageal reflux disease and Helicobacter pylori infection.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Meta-analysis of the effectiveness of esomeprazole in gastroesophageal reflux disease and Helicobacter pylori infection.* J Clin Pharm Ther. 2015 Aug;40(4):368-75 Authors: Teng M, Khoo AL, Zhao YJ, Lin L, Lim BP, Wu TS, Dan YY Abstract WHAT IS KNOWN AND OBJECTIVE: Proton pump inhibitors (PPIs) are one of the most widely used classes of drugs. However, the quantum clinical benefit of newer and more expensive PPIs over the older generation PPIs remains uncertain. This meta-analysis sought to assess the clinical and s... περισσότερα »
Correlation between hypersensitivity induced by esophageal acid infusion and the baseline impedance level in patients with suspected gastroesophageal reflux.
[image: http:--production.springer.de-OnlineReso] Related Articles *Correlation between hypersensitivity induced by esophageal acid infusion and the baseline impedance level in patients with suspected gastroesophageal reflux.* J Gastroenterol. 2015 Jul;50(7):735-43 Authors: Seo AY, Shin CM, Kim N, Yoon H, Park YS, Lee DH Abstract OBJECTIVES: To evaluate the relevance between the pH parameters and baseline impedance level or esophageal hypomotility in patients with suspected gastroesophageal reflux. METHOD: The recordings of 51 patients with heartburn, acid regurgitation, globus or... περισσότερα »
The utility of endoscopy and multichannel intraluminal impedance testing in children with cough and wheezing.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *The utility of endoscopy and multichannel intraluminal impedance testing in children with cough and wheezing.* Pediatr Pulmonol. 2014 Nov;49(11):1090-6 Authors: Rosen R, Amirault J, Johnston N, Haver K, Khatwa U, Rubinstein E, Nurko S Abstract BACKGROUND: Gastroesophageal reflux (GER) has been implicated as a causal factor in respiratory disease but prior studies have focused on the role of acid alone in the genesis of symptoms. Prior studies have relied on pH probe testing but this is blind to non-acid reflux whi... περισσότερα »
Waardenburg syndrome type I: Dental phenotypes and genetic analysis of an extended family.
*Waardenburg syndrome type I: Dental phenotypes and genetic analysis of an extended family.* Med Oral Patol Oral Cir Bucal. 2016 Mar 31;:0 Authors: Sólia-Nasser L, de Aquino SN, Paranaíba LR, Gomes A, Dos-Santos-Neto P, Coletta RD, Cardoso AF, Frota AC, Martelli-Júnior H Abstract BACKGROUND: The aim of this study was to describe the pattern of inheritance and the clinical features in a large family with Waardenburg syndrome type I (WS1), detailing the dental abnormalities and screening for PAX3 mutations. MATERIAL AND METHODS: To characterize the pattern of inheritance and clinic... περισσότερα »
Putative digenic inheritance of heterozygous RP1L1 and C2orf71 null mutations in syndromic retinal dystrophy.
*Putative digenic inheritance of heterozygous RP1L1 and C2orf71 null mutations in syndromic retinal dystrophy.* Ophthalmic Genet. 2016 Mar 30;:1-6 Authors: Liu YP, Bosch DG, Siemiatkowska AM, Rendtorff ND, Boonstra FN, Möller C, Tranebjærg L, Katsanis N, Cremers FP Abstract BACKGROUND: Retinitis pigmentosa (RP) is the most common cause of inherited retinal degeneration and can occur in non-syndromic and syndromic forms. Syndromic RP is accompanied by other symptoms such as intellectual disability, hearing loss, or congenital abnormalities. Both forms are known to exhibit complex ... περισσότερα »
Benign Odontogenic Tumors
Origins, Immunophenotypic Features, and Genetic Alterations: AbstractOdontogenic tumors are lesions derived from the epithelial and/or mesenchymal elements of the tooth-forming apparatus and are therefore found within the jaw bone or soft tissue overlying teeth. These tooth development-associated tumors are generally benign, but several odontogenic tumors are capable of aggressive growth and locally invasive behavior with a high rate of recurrence. Benign odontogenic tumors can pose diagnostic challenges because of overlapping histology, a lack of distinct phenotypic and molecular... περισσότερα »
Syndromic Retinitis pigmentosa (RP) is accompanied by other symptoms such as intellectual disability, hearing loss, or congenital abnormalities.
Putative digenic inheritance of heterozygous RP1L1 and C2orf71 null mutations in syndromic retinal dystrophy.: Ophthalmic Genet. 2016 Mar 30;:1-6 Authors: Liu YP, Bosch DG, Siemiatkowska AM, Rendtorff ND, Boonstra FN, Möller C, Tranebjærg L, Katsanis N, Cremers FP Abstract BACKGROUND: Retinitis pigmentosa (RP) is the most common cause of inherited retinal degeneration and can occur in non-syndromic and syndromic forms. Syndromic RP is accompanied by other symptoms such as intellectual disability, hearing loss, or congenital abnormalities. Both forms are known to exhibit complex ge... περισσότερα »
Waardenburg syndrome type I
: Dental phenotypes and genetic analysis of an extended family.: Med Oral Patol Oral Cir Bucal. 2016 Mar 31;:0 Authors: Sólia-Nasser L, de Aquino SN, Paranaíba LR, Gomes A, Dos-Santos-Neto P, Coletta RD, Cardoso AF, Frota AC, Martelli-Júnior H Abstract BACKGROUND: The aim of this study was to describe the pattern of inheritance and the clinical features in a large family with Waardenburg syndrome type I (WS1), detailing the dental abnormalities and screening for PAX3 mutations. MATERIAL AND METHODS: To characterize the pattern of inheritance and clinical features, 29 family member...περισσότερα »
Pediatric Thyroid Cancer.
A National Perspective of the Risk, Presentation, and Outcomes of Pediatric Thyroid Cancer.: JAMA Otolaryngol Head Neck Surg. 2016 Mar 31; Authors: Al-Qurayshi Z, Hauch A, Srivastav S, Aslam R, Friedlander P, Kandil E Abstract Importance: Thyroid cancer is the most common endocrine malignant neoplasm in children and adolescents. Despite a more advanced presentation of thyroid cancer, younger patients tend to have a more favorable prognosis and a lower mortality rate than adults with thyroid cancer. Objective: To examine the presentation and outcomes of thyroid cancer in pediatric...περισσότερα »
LORAKS makes better SENSE: Phase-constrained partial fourier SENSE reconstruction without phase calibration
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
Purpose Parallel imaging and partial Fourier acquisition are two classical approaches for accelerated MRI. Methods that combine these approaches often rely on prior knowledge of the image phase, but the need to obtain this prior information can place practical restrictions on the data acquisition strategy. In this work, we propose and evaluate SENSE-LORAKS, which enables […]
MR fingerprinting for rapid quantification of myocardial T1, T2, and proton spin density
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
Purpose To introduce a two-dimensional MR fingerprinting (MRF) technique for quantification of T1, T2, and M0 in myocardium. Methods An electrocardiograph-triggered MRF method is introduced for mapping myocardial T1, T2, and M0 during a single breath-hold in as short as four heartbeats. The pulse sequence uses variable flip angles, repetition times, inversion recovery times, and […]
Hexagonal gradient scheme with RF spoiling improves spoiling performance for high-flip-angle fast gradient echo imaging
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
Purpose To present a framework in which time-varying gradients are applied with RF spoiling to reduce unwanted signal, particularly at high flip angles. Methods A time-varying gradient spoiler scheme compatible with RF spoiling is defined, in which spoiler gradients cycle through the vertices of a hexagon, which we call hexagonal spoiling. The method is compared […]
18 FFE@SNAP—a specific PET tracer for melanin-concentrating hormone receptor 1 imaging?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
Abstract Background The melanin-concentrating hormone receptor 1 (MCHR1), which is highly expressed in the lateral hypothalamus, plays a key role in energy homeostasis, obesity and other endocrine diseases. Hence, there is a major interest in in vivo imaging of this receptor. A PET tracer would allow non-invasive in vivo visualization and quantification of the MCHR1. […]
Brain appears to have different mechanisms for reconciling sight and sound
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
A new UCLA psychology study provides insights into how the brain combines sound and vision. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1VXCiC6 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Hammer sound elicited tinnitus in car body repair worker cured by stapedial tenotomy – A case report
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
Publication date: Available online 31 March 2016 Source:Auris Nasus Larynx Author(s): Ryoukichi Ikeda, Hiroshi Hidaka, Hiromitsu Miyazaki, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi Abnormal auditory sensations or tinnitus caused by abnormal middle ear muscle contraction are extremely rare and uncomfortable for patients. A 67-year-old man who performed paint and body work for cars presented at […]
Healthy cooking techniques: Boost flavor and cut calories
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 46 δευτερόλεπτα
Use these healthy-cooking techniques to capture the flavor and nutrients of food without adding excessive fat or salt. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RIzWWd via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Submucosal Lipoma: a Rare Cause of Recurrent Intestinal Obstruction and Intestinal Intussusception.
[image: http:--production.springer.de-OnlineReso] Related Articles *Submucosal Lipoma: a Rare Cause of Recurrent Intestinal Obstruction and Intestinal Intussusception.* J Gastrointest Surg. 2015 Sep;19(9):1733-5 Authors: Jiang RD, Zhi XT, Zhang B, Chen ZQ, Li T Abstract Intestinal lipomas are rare nonepithelial tumors that are usually detected incidentally. They are usually asymptomatic, but lipomas larger than 2 cm may become symptomatic due to obstruction, bleeding, or intussusception. Adult intussusception due to intestinal lipoma is a very rare condition. In this paper, we re... περισσότερα »
Functional Nerve Preservation in Extracranial Head and Neck Schwannoma Surgery.
Functional Nerve Preservation in Extracranial Head and Neck Schwannoma Surgery.: JAMA Otolaryngol Head Neck Surg. 2016 Mar 31; Authors: Ijichi K, Kawakita D, Maseki S, Beppu S, Takano G, Murakami S Abstract Importance: A schwannoma is an uncommon, benign neurogenic tumor of Schwann cells. Tumor enucleation is the recommended surgical method to preserve function of the original nerve, although enucleation does not guarantee completely intact nerve function after the operation. Objective: To establish a strategy for functional preservation in extracranial head and neck schwannoma tr... περισσότερα »
Nutrition in cachexia: from bench to bedside.
*Nutrition in cachexia: from bench to bedside.* J Cachexia Sarcopenia Muscle. 2016 Mar 11; Authors: Konishi M, Ishida J, von Haehling S, Anker SD, Springer J Abstract As malnutrition is often present in cachexia, nutritional intervention has been one of the widely accepted strategies. A literature review of cachexia models with dietary interventions in the present issue of this journal pointed out that the majority of nutrient intervention studies were of n-3 fatty acid, mainly eicosapentaenoic acid and docosahexaenoic acid. Effect on protein catabolism and anti-inflammation are m... περισσότερα »
Nutrition in cachexia: from bench to bedside.
*Nutrition in cachexia: from bench to bedside.* J Cachexia Sarcopenia Muscle. 2016 Mar 11; Authors: Konishi M, Ishida J, von Haehling S, Anker SD, Springer J Abstract As malnutrition is often present in cachexia, nutritional intervention has been one of the widely accepted strategies. A literature review of cachexia models with dietary interventions in the present issue of this journal pointed out that the majority of nutrient intervention studies were of n-3 fatty acid, mainly eicosapentaenoic acid and docosahexaenoic acid. Effect on protein catabolism and anti-inflammation are m... περισσότερα »
Performance improvement and patient safety program (PIPS) guided quality improvement initiatives can significantly reduce CT imaging in pediatric trauma patients.
*Performance improvement and patient safety program (PIPS) guided quality improvement initiatives can significantly reduce CT imaging in pediatric trauma patients.* J Trauma Acute Care Surg. 2016 Mar 30; Authors: Connelly CR, Yonge JD, Eastes LE, Bilyeu PE, Kemp Bohan PM, Schreiber MA, Azarow KS, Watters JM, Jafri MA Abstract BACKGROUND: Morbidity and mortality of cervical spine (C-Spine) injury in pediatric trauma patients is high, necessitating quick and accurate diagnosis. Best practices emphasize minimizing radiation exposure through decreased reliance on computed tomography ... περισσότερα »
A National Perspective of the Risk, Presentation, and Outcomes of Pediatric Thyroid Cancer.
*A National Perspective of the Risk, Presentation, and Outcomes of Pediatric Thyroid Cancer.* JAMA Otolaryngol Head Neck Surg. 2016 Mar 31; Authors: Al-Qurayshi Z, Hauch A, Srivastav S, Aslam R, Friedlander P, Kandil E Abstract Importance: Thyroid cancer is the most common endocrine malignant neoplasm in children and adolescents. Despite a more advanced presentation of thyroid cancer, younger patients tend to have a more favorable prognosis and a lower mortality rate than adults with thyroid cancer. Objective: To examine the presentation and outcomes of thyroid cancer in pediatri... περισσότερα »
Exploring the Life Impact of Treated Low-Risk Thyroid Cancer.
*Exploring the Life Impact of Treated Low-Risk Thyroid Cancer.* Endocr Pract. 2016 Apr;22(4):513-514 Authors: Sawka AM, Ezzat S, Goldstein DP PMID: 27031656 [PubMed - as supplied by publisher] from pubmed: thyroid cancer http://ift.tt/1q8GTWb via IFTTT
1,25-Dihydroxyvitamin D3 inhibits the proliferation of thyroid cancer stem-like cells via cell cycle arrest.
*1,25-Dihydroxyvitamin D3 inhibits the proliferation of thyroid cancer stem-like cells via cell cycle arrest.* Endocr Res. 2016 Mar 30;:1-8 Authors: Peng W, Wang K, Zheng R, Derwahl M Abstract BACKGROUND: An anti-proliferative effect of vitamin D has been reported in different carcinomas, including thyroid cancer. Cancer stem cells (CSCs), a very small fraction of cancer cells, are widely believed to be responsible for cancer initiation, relapse and metastasis. OBJECTIVES: We addressed the question as to whether CSCs derived from the anaplastic thyroid carcinoma cell lines SW1736,...περισσότερα »
Primary ectopic substernal thyroid cancer with trachea relapse: a case report and opinions of management.
*Primary ectopic substernal thyroid cancer with trachea relapse: a case report and opinions of management.* World J Surg Oncol. 2016;14(1):94 Authors: Ma RM, Lv L, Zheng SR, You J, Huang DP, Guo GL Abstract BACKGROUND: Ectopic substernal thyroid is a rare symptom of thyroid disease that entirely results from the developmental defects at early stages of thyroid embryogenesis and during its descent. Cases were seldom reported as primary ectopic substernal thyroid cancer, especially those with severe local invasion and tracheal relapse. CASE PRESENTATION: In this report, the patient ...περισσότερα »
Arterial stiffness and central hemodynamics in thyroidectomized patients on long-term substitution therapy with levothyroxine.
*Arterial stiffness and central hemodynamics in thyroidectomized patients on long-term substitution therapy with levothyroxine.* Thyroid. 2016 Mar 30; Authors: Laugesen E, Moser E, Sikjaer T, Poulsen P, Rejnmark L Abstract BACKGROUND: Long-term levothyroxine (LT4) therapy targeting thyroid-stimulating hormone (TSH) suppression in hypothyroid patients treated for thyroid cancer has been associated with increased arterial stiffness and increased cardiovascular mortality. However, most patients with hypothyroidism receive LT4 therapy targeting TSH in the normal range. The long-term ... περισσότερα »
Knockdown of TC-1 enhances radiosensitivity of non-small cell lung cancer via the Wnt/β-catenin pathway.
*Knockdown of TC-1 enhances radiosensitivity of non-small cell lung cancer via the Wnt/β-catenin pathway.* Biol Open. 2016 Mar 30; Authors: Wu D, Li L, Yan W Abstract Thyroid cancer 1 (TC-1, C8ofr4) is widely expressed in vertebrates and associated with many kinds of tumors. Previous studies indicated that TC-1 functions as a positive regulator in the Wnt/β-catenin signaling pathway in non-small cell lung cancer (NSCLC). However, its exact role and regulation mechanism in radiosensitivity of NSCLC are still unclear. The expression level of TC-1 was measured by qRT-PCR and western...περισσότερα »
Cervical and breast cancer screening participation for women with chronic conditions in France: results from a national health survey.
*Cervical and breast cancer screening participation for women with chronic conditions in France: results from a national health survey.* BMC Cancer. 2016;16(1):255 Authors: Constantinou P, Dray-Spira R, Menvielle G Abstract BACKGROUND: Comorbidity at the time of diagnosis is an independent prognostic factor for survival among women suffering from cervical or breast cancer. Although cancer screening practices have proven their efficacy for mortality reduction, little is known about adherence to screening recommendations for women suffering from chronic conditions. We investigated ... περισσότερα »
Lysyl Oxidase (LOX) transcriptionally regulates SNAI2 expression and TIMP4 secretion in human cancers.
*Lysyl Oxidase (LOX) transcriptionally regulates SNAI2 expression and TIMP4 secretion in human cancers.* Clin Cancer Res. 2016 Mar 30; Authors: Boufraqech M, Zhang L, Nilubol N, Sadowski SM, Kotian S, Quezado MM, Kebebew E Abstract PURPOSE: Epithelial-to-mesenchymal transition (EMT) is important in cancer progression and metastasis. We and others have previously reported that lysyl oxidase (LOX) is overexpressed in aggressive cancers, is associated with increased mortality, and regulates EMT. However, the mechanism by which LOX mediates EMT is unknown. In this study, we investiga... περισσότερα »
Proteomics in thyroid cytopathology: relevance of MALDI-Imaging in distinguishing malignant from benign lesions.
*Proteomics in thyroid cytopathology: relevance of MALDI-Imaging in distinguishing malignant from benign lesions.* Proteomics. 2016 Mar 31; Authors: Pagni F, De Sio G, Garancini M, Scardilli M, Chinello C, Smith AJ, Bono F, Leni D, Magni F Abstract Several proteomic strategies are used extensively for the purpose of biomarker discovery and in order to obtain insights into the molecular aspects of cancers, using either body fluids or tissue as samples. Among them, MALDI-imaging can be applied to cytological thyroid specimens to investigate the molecular signatures of different pat...περισσότερα »
Thyroid Nodules.
Related Articles *Thyroid Nodules.* N Engl J Med. 2016 Mar 31;374(13):1294 Authors: Seidenwurm D, Breslau J PMID: 27028929 [PubMed - indexed for MEDLINE] from pubmed: thyroid cancer http://ift.tt/1X2iI66 via IFTTT
Thyroid Nodules.
Related Articles *Thyroid Nodules.* N Engl J Med. 2016 Mar 31;374(13):1294 Authors: Beano AM, Zmaili MA, Zayed AA PMID: 27028928 [PubMed - indexed for MEDLINE] from pubmed: thyroid cancer http://ift.tt/1X2iI5X via IFTTT
Thyroid Nodules.
Related Articles *Thyroid Nodules.* N Engl J Med. 2016 Mar 31;374(13):1294-5 Authors: Burman KD, Wartofsky L PMID: 27028927 [PubMed - indexed for MEDLINE] from pubmed: thyroid cancer http://ift.tt/1X2iHPv via IFTTT
A Case of a TSH-secreting Pituitary Adenoma Associated with Evans' Syndrome.
Related Articles *A Case of a TSH-secreting Pituitary Adenoma Associated with Evans' Syndrome.* Tokai J Exp Clin Med. 2015 Jul;40(2):44-50 Authors: Yasuda A, Seki T, Oki M, Takagi A, Inomoto C, Nakamura N, Atsumi H, Baba T, Matsumae M, Sasaki N, Suzuki Y, Fukagawa M Abstract We present a case of a TSH-secreting pituitary adenoma (TSHoma) associated with Evans' syndrome. A 30-year-old woman was referred to our hospital due to purpura and ecchymoses on her limb and body and epistaxis. Evans' syndrome was diagnosed based on idiopathic thrombocytopenic purpura and autoimmune hemolyt... περισσότερα »
Endoplasmic reticulum aminopeptidase 2 is highly expressed in papillary thyroid microcarcinoma with cervical lymph node metastasis.
Related Articles *Endoplasmic reticulum aminopeptidase 2 is highly expressed in papillary thyroid microcarcinoma with cervical lymph node metastasis.* J Cancer Res Ther. 2015 Apr-Jun;11(2):443-6 Authors: Kim WY, Lee JB, Kim HY, Woo SU, Son GS, Bae JW Abstract BACKGROUND: The cervical lymph node metastasis (CLNM) of papillary thyroid microcarcinoma (PTMC) is not uncommon. However, prophylactic cervical lymph node dissection in all PTMC is debatable. Molecular markers of predicting CLNM would help to decide to either do or not do cervical lymph node dissection which might increase ...περισσότερα »
New endoscopic thyroidectomy with the transareola single-site approach: a comparison with the bilateral areolar approach.
Related Articles *New endoscopic thyroidectomy with the transareola single-site approach: a comparison with the bilateral areolar approach.* Surg Laparosc Endosc Percutan Tech. 2015 Apr;25(2):178-84 Authors: Guo BM, Wu B, Kang J, Deng XZ, Qin HL, Fan YB Abstract PURPOSE: We developed the transareola single-site approach (TASSA) for less invasive endoscopic thyroidectomy to avoid scars on exposed areas. Here, we report our experience with the TASSA technique in treatment of benign thyroid tumors and evaluate its feasibility through comparison with the bilateral areolar approach (B... περισσότερα »
Evidence for Ethylene-Vinyl-Alcohol-Copolymer Liquid Embolic Agent as a Monotherapy in Treatment of Endoleaks
Publication date: Available online 31 March 2016 *Source:*European Journal of Vascular and Endovascular Surgery Author(s): R.W. Jamieson, P. Bachoo, A.L. Tambyraja ObjectiveEndoleak remains the Achilles heel of endovascular aneurysm repair and the exclusion of Type II endoleaks, in particular, remains challenging. This systematic review presents the evidence for ethylene-vinyl-alcohol-copolymer liquid embolic agent as a monotherapy in the treatment of endoleaks.MethodsA systematic literature search was performed for all studies reporting the use of liquid embolic agent as a sole age... περισσότερα »
CD47 Enhances In Vivo Functionality of Artificial Antigen-Presenting Cells.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *CD47 Enhances In Vivo Functionality of Artificial Antigen-Presenting Cells.* Clin Cancer Res. 2015 May 1;21(9):2075-83 Authors: Bruns H, Bessell C, Varela JC, Haupt C, Fang J, Pasemann S, Mackensen A, Oelke M, Schneck JP, Schütz C Abstract PURPOSE: Artificial antigen-presenting cells, aAPC, have successfully been used to stimulate antigen-specific T-cell responses in vitro as well as in vivo. Although aAPC compare favorably with autologous dendritic cells in vitro, their effect in vivo might be diminished through... περισσότερα »
Primary mucosal melanoma of the head and neck in Denmark, 1982-2012: Demographic and clinical aspects. A retrospective DAHANCA study.
*Primary mucosal melanoma of the head and neck in Denmark, 1982-2012: Demographic and clinical aspects. A retrospective DAHANCA study.* Acta Oncol. 2016 Mar 31;:1-8 Authors: Lawaetz M, Birch-Johansen F, Friis S, Eriksen JG, Kiss K, Gade S, Møller-Madsen M, Pourbordbari N, von Buchwald C Abstract Background The study was performed to determine the epidemiological, clinical, and histopathological characteristics and prognosis of primary mucosal melanoma of the head and neck (MMHN) in Denmark. Material and methods This was a national retrospective multicenter study of patients diagn... περισσότερα »
Oncotarget strategies for Herpes Simplex Virus-1.
*Oncotarget strategies for Herpes Simplex Virus-1.* Curr Gene Ther. 2016 Mar 31; Authors: Zhang L, Tatsuya T, Nishiyama Y Abstract The high level of manipulability of viral genome has set up HSV-1 to be an ideal viral vector for oncolytic virotherapy. In the past two decades, several oncolytic HSV-1 viruses have been successfully developed and assessed in animal studies. Accumulated evidences show that oncolytic HSV-1 can efficiently infect many tumor cells and augment anti-tumor effect by induction of systemic innate and adaptive immune responses. Inspiring results have been acc...περισσότερα »
Comparative study between two different staging systems (AJCC TNM VS BALLANTYNE'S) for mucosal melanomas of the Head & Neck.
*Comparative study between two different staging systems (AJCC TNM VS BALLANTYNE'S) for mucosal melanomas of the Head & Neck.* Med Oral Patol Oral Cir Bucal. 2016 Mar 31;:0 Authors: Luna-Ortiz K, Aguilar-Romero M, Villavicencio-Valencia V, Zepeda-Castilla E, Vidrio-Morgado H, Peteuil N, Mosqueda-Taylor A Abstract BACKGROUND: Mucosal melanoma (MM) of head and neck (H&N) is a rare entity with a quite poor prognosis. Ballantyne's staging system has been commonly used since 1970. In the 7th edition of the AJCC Staging Manual a new chapter for the staging of TNM Classification system f... περισσότερα »
Primary mucosal melanoma of the head and neck in Denmark, 1982-2012: Demographic and clinical aspects. A retrospective DAHANCA study.
*Primary mucosal melanoma of the head and neck in Denmark, 1982-2012: Demographic and clinical aspects. A retrospective DAHANCA study.* Acta Oncol. 2016 Mar 31;:1-8 Authors: Lawaetz M, Birch-Johansen F, Friis S, Eriksen JG, Kiss K, Gade S, Møller-Madsen M, Pourbordbari N, von Buchwald C Abstract Background The study was performed to determine the epidemiological, clinical, and histopathological characteristics and prognosis of primary mucosal melanoma of the head and neck (MMHN) in Denmark. Material and methods This was a national retrospective multicenter study of patients diagn... περισσότερα »
Performance improvement and patient safety program (PIPS) guided quality improvement initiatives can significantly reduce CT imaging in pediatric trauma patients.
*Performance improvement and patient safety program (PIPS) guided quality improvement initiatives can significantly reduce CT imaging in pediatric trauma patients.* J Trauma Acute Care Surg. 2016 Mar 30; Authors: Connelly CR, Yonge JD, Eastes LE, Bilyeu PE, Kemp Bohan PM, Schreiber MA, Azarow KS, Watters JM, Jafri MA Abstract BACKGROUND: Morbidity and mortality of cervical spine (C-Spine) injury in pediatric trauma patients is high, necessitating quick and accurate diagnosis. Best practices emphasize minimizing radiation exposure through decreased reliance on computed tomography ... περισσότερα »
A National Perspective of the Risk, Presentation, and Outcomes of Pediatric Thyroid Cancer.
*A National Perspective of the Risk, Presentation, and Outcomes of Pediatric Thyroid Cancer.* JAMA Otolaryngol Head Neck Surg. 2016 Mar 31; Authors: Al-Qurayshi Z, Hauch A, Srivastav S, Aslam R, Friedlander P, Kandil E Abstract Importance: Thyroid cancer is the most common endocrine malignant neoplasm in children and adolescents. Despite a more advanced presentation of thyroid cancer, younger patients tend to have a more favorable prognosis and a lower mortality rate than adults with thyroid cancer. Objective: To examine the presentation and outcomes of thyroid cancer in pediatri... περισσότερα »
Exploring the Life Impact of Treated Low-Risk Thyroid Cancer.
*Exploring the Life Impact of Treated Low-Risk Thyroid Cancer.* Endocr Pract. 2016 Apr;22(4):513-514 Authors: Sawka AM, Ezzat S, Goldstein DP PMID: 27031656 [PubMed - as supplied by publisher] from pubmed: thyroid cancer http://ift.tt/1q8GTWb via IFTTT
1,25-Dihydroxyvitamin D3 inhibits the proliferation of thyroid cancer stem-like cells via cell cycle arrest.
*1,25-Dihydroxyvitamin D3 inhibits the proliferation of thyroid cancer stem-like cells via cell cycle arrest.* Endocr Res. 2016 Mar 30;:1-8 Authors: Peng W, Wang K, Zheng R, Derwahl M Abstract BACKGROUND: An anti-proliferative effect of vitamin D has been reported in different carcinomas, including thyroid cancer. Cancer stem cells (CSCs), a very small fraction of cancer cells, are widely believed to be responsible for cancer initiation, relapse and metastasis. OBJECTIVES: We addressed the question as to whether CSCs derived from the anaplastic thyroid carcinoma cell lines SW1736,...περισσότερα »
Primary ectopic substernal thyroid cancer with trachea relapse: a case report and opinions of management.
*Primary ectopic substernal thyroid cancer with trachea relapse: a case report and opinions of management.* World J Surg Oncol. 2016;14(1):94 Authors: Ma RM, Lv L, Zheng SR, You J, Huang DP, Guo GL Abstract BACKGROUND: Ectopic substernal thyroid is a rare symptom of thyroid disease that entirely results from the developmental defects at early stages of thyroid embryogenesis and during its descent. Cases were seldom reported as primary ectopic substernal thyroid cancer, especially those with severe local invasion and tracheal relapse. CASE PRESENTATION: In this report, the patient ...περισσότερα »
Arterial stiffness and central hemodynamics in thyroidectomized patients on long-term substitution therapy with levothyroxine.
*Arterial stiffness and central hemodynamics in thyroidectomized patients on long-term substitution therapy with levothyroxine.* Thyroid. 2016 Mar 30; Authors: Laugesen E, Moser E, Sikjaer T, Poulsen P, Rejnmark L Abstract BACKGROUND: Long-term levothyroxine (LT4) therapy targeting thyroid-stimulating hormone (TSH) suppression in hypothyroid patients treated for thyroid cancer has been associated with increased arterial stiffness and increased cardiovascular mortality. However, most patients with hypothyroidism receive LT4 therapy targeting TSH in the normal range. The long-term ... περισσότερα »
Knockdown of TC-1 enhances radiosensitivity of non-small cell lung cancer via the Wnt/β-catenin pathway.
*Knockdown of TC-1 enhances radiosensitivity of non-small cell lung cancer via the Wnt/β-catenin pathway.* Biol Open. 2016 Mar 30; Authors: Wu D, Li L, Yan W Abstract Thyroid cancer 1 (TC-1, C8ofr4) is widely expressed in vertebrates and associated with many kinds of tumors. Previous studies indicated that TC-1 functions as a positive regulator in the Wnt/β-catenin signaling pathway in non-small cell lung cancer (NSCLC). However, its exact role and regulation mechanism in radiosensitivity of NSCLC are still unclear. The expression level of TC-1 was measured by qRT-PCR and western...περισσότερα »
Cervical and breast cancer screening participation for women with chronic conditions in France: results from a national health survey.
*Cervical and breast cancer screening participation for women with chronic conditions in France: results from a national health survey.* BMC Cancer. 2016;16(1):255 Authors: Constantinou P, Dray-Spira R, Menvielle G Abstract BACKGROUND: Comorbidity at the time of diagnosis is an independent prognostic factor for survival among women suffering from cervical or breast cancer. Although cancer screening practices have proven their efficacy for mortality reduction, little is known about adherence to screening recommendations for women suffering from chronic conditions. We investigated ... περισσότερα »
Lysyl Oxidase (LOX) transcriptionally regulates SNAI2 expression and TIMP4 secretion in human cancers.
*Lysyl Oxidase (LOX) transcriptionally regulates SNAI2 expression and TIMP4 secretion in human cancers.* Clin Cancer Res. 2016 Mar 30; Authors: Boufraqech M, Zhang L, Nilubol N, Sadowski SM, Kotian S, Quezado MM, Kebebew E Abstract PURPOSE: Epithelial-to-mesenchymal transition (EMT) is important in cancer progression and metastasis. We and others have previously reported that lysyl oxidase (LOX) is overexpressed in aggressive cancers, is associated with increased mortality, and regulates EMT. However, the mechanism by which LOX mediates EMT is unknown. In this study, we investiga... περισσότερα »
Proteomics in thyroid cytopathology: relevance of MALDI-Imaging in distinguishing malignant from benign lesions.
*Proteomics in thyroid cytopathology: relevance of MALDI-Imaging in distinguishing malignant from benign lesions.* Proteomics. 2016 Mar 31; Authors: Pagni F, De Sio G, Garancini M, Scardilli M, Chinello C, Smith AJ, Bono F, Leni D, Magni F Abstract Several proteomic strategies are used extensively for the purpose of biomarker discovery and in order to obtain insights into the molecular aspects of cancers, using either body fluids or tissue as samples. Among them, MALDI-imaging can be applied to cytological thyroid specimens to investigate the molecular signatures of different pat...περισσότερα »
Thyroid Nodules.
Related Articles *Thyroid Nodules.* N Engl J Med. 2016 Mar 31;374(13):1294 Authors: Seidenwurm D, Breslau J PMID: 27028929 [PubMed - indexed for MEDLINE] from pubmed: thyroid cancer http://ift.tt/1X2iI66 via IFTTT
Thyroid Nodules.
Related Articles *Thyroid Nodules.* N Engl J Med. 2016 Mar 31;374(13):1294 Authors: Beano AM, Zmaili MA, Zayed AA PMID: 27028928 [PubMed - indexed for MEDLINE] from pubmed: thyroid cancer http://ift.tt/1X2iI5X via IFTTT
Thyroid Nodules.
Related Articles *Thyroid Nodules.* N Engl J Med. 2016 Mar 31;374(13):1294-5 Authors: Burman KD, Wartofsky L PMID: 27028927 [PubMed - indexed for MEDLINE] from pubmed: thyroid cancer http://ift.tt/1X2iHPv via IFTTT
A Case of a TSH-secreting Pituitary Adenoma Associated with Evans' Syndrome.
Related Articles *A Case of a TSH-secreting Pituitary Adenoma Associated with Evans' Syndrome.* Tokai J Exp Clin Med. 2015 Jul;40(2):44-50 Authors: Yasuda A, Seki T, Oki M, Takagi A, Inomoto C, Nakamura N, Atsumi H, Baba T, Matsumae M, Sasaki N, Suzuki Y, Fukagawa M Abstract We present a case of a TSH-secreting pituitary adenoma (TSHoma) associated with Evans' syndrome. A 30-year-old woman was referred to our hospital due to purpura and ecchymoses on her limb and body and epistaxis. Evans' syndrome was diagnosed based on idiopathic thrombocytopenic purpura and autoimmune hemolyt... περισσότερα »
