Negative pressure wound therapy for the management of flaps with venous congestion
Purpose The aim of this report is to evaluate the utility of negative pressure wound therapy (NPWT) for rescuing flaps with venous congestion not attributable to a mechanical etiology and that cannot be surgically salvaged. Patients and methods A total of 12 patients suffered from partial or total flap congestion after pedicle or free-flap reconstruction was included. All patients underwent NPWT between 3 and 10 days postoperatively. Results All congested flaps survived after the application of NPWT. Nine patients suffered partial flap loss and this was addressed through debrid... περισσότερα »
The lower medial thigh perforator flap for lower extremity reconstruction: Preliminary results
Background The lower medial thigh perforator (LMTP) flap is an alternative source for lower extremity reconstruction. In this article, we report the preliminary results of reconstruction of the lower extremity with a series of patients by the lower medial thigh perforator flap. Patients and methods From January 2015 until August 2015, we performed six cases of lower extremity reconstruction with the LMTP flap. The defect locations included the distal leg (1 case) and the proximal leg (2 cases), the left foot (2 cases), and the right foot (1 case). The perforators of the flap desi... περισσότερα »
Mitteilungen der Deutschen Gesellschaft für Kieferorthopädie
from #Dental via xlomafota13 on Inoreader http://ift.tt/1PfM4MN via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Botulinum toxin-A injections vs radiotherapy for drooling in ALS
Botulinum toxin-A injections vs radiotherapy for drooling in ALS: Objectives Botulinum neurotoxin (BoNT) injections in the salivary glands and radiotherapy (RT) on these glands are commonly used to alleviate severe drooling in patients with amyotrophic lateral sclerosis (ALS). This study compares BoNT type A with RT based on patient-rated evaluations. Materials & methods A prospective randomized controlled pilot study to compare RT (*n* = 10; on the parotid and the posterior part of the submandibular glands) with BoNT-A treatment (*n* = 10; in the parotid glands only, because of the ...περισσότερα »
Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression
Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression: [image: cover.gif?v=1&s=f3d98c753a39c60ab03ce3a3] Summary COX-2 and its product PGE2 enhance carcinogenesis and tumor progression, which has been previously reported in melanoma. As most COX inhibitors cause much toxicity, the downstream microsomal PGE2 synthase-1 (mPGES1) is a consideration for targeting. Human melanoma TMAs were employed for testing mPGES1 protein staining intensity and percentage levels and both increased with clinical stage; employing a different Sta... περισσότερα »
Interleukin-1B 31 C>T polymorphism combined with Helicobacter pylori-modified gastric cancer susceptibility: evidence from 37 studies
Interleukin-1B 31 C>T polymorphism combined with Helicobacter pylori-modified gastric cancer susceptibility: evidence from 37 studies: Abstract Gastric cancer is one of the most common malignancies worldwide. Interleukin-1-beta (IL-1β) is a pro-inflammatory cytokine and potent inhibitor of gastric acid secretion. Some studies provided evidence of the association between *IL-1B* 31 polymorphism and gastric cancer risk while other studies did not. Therefore, we conducted a comprehensive meta-analysis to reassess the association. A systematic literature search of the PubMed and EMBASE...περισσότερα »
Invasive ductal carcinoma and mantle cell lymphoma
Synchronous presentation of invasive ductal carcinoma and mantle cell lymphoma: a diagnostic challenge in menopausal patients: Synchronous presentation of breast carcinoma and non-Hodgkin lymphoma (NHL) is a rare occurrence (Bradford PT, Freedman DM, Goldstein AM, Tucker MA. Increased risk of second primary cancers after a diagnosis of melanoma. *Arch Dermatol* 2010;*146*:265–72; Dutta Roy S, Stafford JA, Scally J, Selvachandran SN. A rare case of breast carcinoma co-existing with axillary mantle cell lymphoma. *World J Surg Oncol* 2003;*1*:27; Suresh Attili VS, Dadhich HK, Rao CR,... περισσότερα »
Benign pineal cyst lined with normal choroid plexus
Benign pineal cyst lined with normal choroid plexus mimicking tumour in a young girl with exotropia: Description A 4-year-old girl presented with a 4-month history of progressive exotropia. There was no headache, no impaired upgaze, no nystagmus and no vision changes. Complete neurological examination was otherwise normal. MRI of the brain revealed a 1.5 cm cystic lesion in the pineal region. The cyst had a smooth margin lined by a thin wall of <1 mm that was homogenously enhancing on contrast scan. Compared to cerebrospinal fluid, the cyst content was isointense in T1 and hyperinte... περισσότερα »
Body rash, myalgias, dark urine, nausea and vomiting
Parvovirus leading to thrombotic microangiopathy in a healthy adult: A healthy 47-year-old man initially presented with symptoms of body rash, myalgias, dark urine, nausea and vomiting. Acute kidney injury, and positive urine analysis for blood and protein warranted a kidney biopsy, which revealed micro thrombi in kidney vasculature, suggestive of thrombotic microangiopathy. Serology revealed positive parvovirus B19 IgM antibodies and biopsy tests revealed a viral genome on PCR. Despite plasma exchanges and treatment with rituximab, renal function continued to deteriorate to end-st...περισσότερα »
Pain and progressive swelling over both hips of 2 years duration
Hyperphosphatemic tumoural calcinosis: Description A 13-year-old girl presented with pain and progressive swelling over both hips of 2 years duration along with restriction of movements at the hips. There was no history of trauma, back ache, fever, renal calculi, polyuria, fractures and involvement of other joints. There was no similar illness in other family members. On examination, there were swellings of more than 20 cm over both hips with painful restriction of movements. The rest of the examination was unremarkable. The patient's blood biochemistry revealed a high-phosphorus le... περισσότερα »
At the Beach: To Jump or Not to Jump?
Pediatric Emergency Care from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1OJfEJd via IFTTT
Microvascular dysfunction as opposed to conduit artery disease explains sex-specific chest pain in emergency department patients with low to moderate cardiac risk
Clinical Therapeutics from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Pvc3BV via IFTTT
Researchers may hold key to developing a single treatment against several types of Ebola
University of Texas Medical Branch at Galveston from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Pvc2Oz via IFTTT
Decreased movement path tortuosity is associated with improved functional status in patients with traumatic brain injury
Journal of Head Trauma Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Pvc2xZ via IFTTT
Young people after Obamacare: some ER visits down, others way up
American College of Emergency Physicians News from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Pvc0Gm via IFTTT
The effect of early intensive care on recovery from whiplash associated disorders - Results of a population based cohort study
Archives of Physical Medicine and Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Pvc0pM via IFTTT
Compensatory neural tract from contralesional fornical body to ipsilesional medial temporal lobe in a patient with mild traumatic brain injury: a case report
American Journal of Physical Medicine & Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1OJfCkt via IFTTT
Independent association of vitamin D with physical function in people with chronic spinal cord injury
Archives of Physical Medicine and Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PvbZSK via IFTTT
An oxygen mask to prevent sequelae from stroke?
Inserm (Institut national de la santé et de la recherche médicale) from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1OJfC3Y via IFTTT
Out-of-hospital cardiac arrest: the prospect of E-CPR in the Maastricht region
Netherlands Heart Journal from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PvbVT6 via IFTTT
A research confirms that melatonin could be of use for preventing sepsis, first cause of death in hospital ICUs
University of Granada Health Science and Technology News from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PvbVST via IFTTT
An evidence-based approach to minimizing acute procedural pain in the emergency department and beyond
Pediatric Emergency Care from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1OJfzoO via IFTTT
Clinical utility and psychometric properties of the Traumatic Brain Injury Quality of Life scale (TBI-QOL) in US military service members
Journal of Head Trauma Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1OJfAZR via IFTTT
Combined approaches for the relief of spinal cord injury-induced neuropathic pain
Complementary Therapies in Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1OJfAJk via IFTTT
Recovery of an injured cingulum via the lateral cholinergic pathway in a patient with traumatic brain injury
American Journal of Physical Medicine & Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PvbXud via IFTTT
Physical maturity and concussion symptom duration among adolescent ice hockey players
The Journal of Pediatrics from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1PvbXdJ via IFTTT
The Effectiveness of Human Parathyroid Hormone and Low-Intensity Pulsed Ultrasound on the Fracture Healing in Osteoporotic Bones
The Effectiveness of Human Parathyroid Hormone and Low-Intensity Pulsed Ultrasound on the Fracture Healing in Osteoporotic Bones: AbstractOsteoporotic fracture has become a major public health problem, and until today, the treatments available are not satisfactory. While there is growing evidence to support the individual treatment of parathyroid hormone (PTH) administration and low-intensity pulsed ultrasound (LIPUS) exposure as respectively systemic and local therapies during osteoporotic fracture healing, their effects have not yet been investigated when introduced concurrently....περισσότερα »
Sensing Conductive Hydrogels for Rapid Detection of Cytokines in Blood
Sensing Conductive Hydrogels for Rapid Detection of Cytokines in Blood: [image: Thumbnail image of graphical abstract] *Conducting polymer hydrogel* is fabricated atop gold or ITO electrodes and is functionalized with monoclonal antibodies. Binding of interferon-γ molecules causes redox properties of conductive hydrogel to change in a concentration-dependent fashion without the need for washing or sample handling steps. This conductive hydrogel remains functional in a fouling media such as whole blood.
Flexible pH-Sensing Hydrogel Fibers for Epidermal Applications
Flexible pH-Sensing Hydrogel Fibers for Epidermal Applications: Epidermal pH is an indication of the skin's physiological condition. For example, pH of wound can be correlated to angiogenesis, protease activity, bacterial infection, etc. Chronic nonhealing wounds are known to have an elevated alkaline environment, while healing process occurs more readily in an acidic environment. Thus, dermal patches capable of continuous pH measurement can be used as point-of-care systems for monitoring skin disorder and the wound healing process. Here, pH-responsive hydrogel fibers are presented... περισσότερα »
Printed Sensors Evaluated for Glucose Measurement in Exhaled Breath
Printed Sensors Evaluated for Glucose Measurement in Exhaled Breath: [image: CPI] Just about any diabetic will tell you pinpricks are a painfully annoying but ever-present part of managing the disease. *Applied Nanodetector*s Ltd. (Middlesex, UK) and the Centre for Process Innovation in the UK are working on developing a breath testing device that may be able to accurately estimate the levels of glucose in the plasma. The glucose “breathalyzer” would measure concentrations of volatile organic compounds exhaled into the device using printed sensors that can be made cheap enough ... περισσότερα »
Elastomeric enriched biodegradable polyurethane sponges for critical bone defects: a successful case study reducing donor site morbidity
Elastomeric enriched biodegradable polyurethane sponges for critical bone defects: a successful case study reducing donor site morbidity: AbstractBone substitutes have been a critical issue as the natural source can seldom provide enough bone to support full healing. No bone substitute complies with all necessary functions and characteristics that an autograft does. Polyurethane sponges have been used as a surgical alternative to cancellous bone grafts for critical bone defect donor sites. Critical bone defects were created on the tibial tuberosity and iliac crest using an ovine m... περισσότερα »
Implantable neurotechnologies: a review of integrated circuit neural amplifiers
Implantable neurotechnologies: a review of integrated circuit neural amplifiers: AbstractNeural signal recording is critical in modern day neuroscience research and emerging neural prosthesis programs. Neural recording requires the use of precise, low-noise amplifier systems to acquire and condition the weak neural signals that are transduced through electrode interfaces. Neural amplifiers and amplifier-based systems are available commercially or can be designed in-house and fabricated using integrated circuit (IC) technologies, resulting in very large-scale integration or applica... περισσότερα »
Performance Evaluation of Human Detection Systems for Robot Safety
Performance Evaluation of Human Detection Systems for Robot Safety: AbstractDetecting and tracking people is becoming more important in robotic applications because of the increasing demand for collaborative work in which people interact closely with and in the same workspace as robots. New safety standards allow people to work next to robots, but require that they be protected from harm while they do so. Sensors that detect and track people are a natural way of implementing the necessary safety monitoring, and have the added advantage that the information about where the people ar...περισσότερα »
Textile cell-free scaffolds for in situ tissue engineering applications
Textile cell-free scaffolds for in situ tissue engineering applications: AbstractIn this article, the benefits offered by micro-fibrous scaffold architectures fabricated by textile manufacturing techniques are discussed: How can established and novel fiber-processing techniques be exploited in order to generate templates matching the demands of the target cell niche? The problems related to the development of biomaterial fibers (especially from nature-derived materials) ready for textile manufacturing are addressed. Attention is also paid on how biological cues may be incorporated ... περισσότερα »
Corneal Dendritic Cell Density Is Associated with Subbasal Nerve Plexus Features, Ocular Surface Disease Index, and Serum Vitamin D in Evaporative Dry Eye Disease
Corneal Dendritic Cell Density Is Associated with Subbasal Nerve Plexus Features, Ocular Surface Disease Index, and Serum Vitamin D in Evaporative Dry Eye Disease: Dry eye disease (DED) has evolved into a major public health concern with ocular discomfort and pain being responsible for significant morbidity associated with DED. However, the etiopathological factors contributing to ocular pain associated with DED are not well understood. The current IVCM based study investigated the association between corneal dendritic cell density (DCD), corneal subbasal nerve plexus (SBNP) feature... περισσότερα »
Metformin Synergistically Enhances Cisplatin-Induced Cytotoxicity in Esophageal Squamous Cancer Cells under Glucose-Deprivation Conditions
Metformin Synergistically Enhances Cisplatin-Induced Cytotoxicity in Esophageal Squamous Cancer Cells under Glucose-Deprivation Conditions: Previous studies suggest that metformin may exert a protective effect on cisplatin-induced cytotoxicity in cancer cells, and this finding has led to a caution for considering metformin use in the treatment of cancer patients. However, in this paper we provide the first demonstration that metformin synergistically augments cisplatin cytotoxicity in the esophageal squamous cancer cell line, ECA109, under glucose-deprivation conditions, which may b...περισσότερα »
Immunohistochemistry for the detection of neural and inflammatory cells in equine brain tissue
Immunohistochemistry for the detection of neural and inflammatory cells in equine brain tissue: Phenotypic characterization of cellular responses in equine infectious encephalitides has had limited description of both peripheral and resident cell populations in central nervous system (CNS) tissues due to limited species-specific reagents that react with formalin-fixed, paraffin embedded tissue (FFPE). This study identified a set of antibodies for investigating the immunopathology of infectious CNS diseases in horses. Multiple commercially available staining reagents and antibodies d... περισσότερα »
Human and primate-specific microRNAs in cancer
Human and primate-specific microRNAs in cancer: Evolution, and significance in comparison with more distantly-related research models: The largest proportion of microRNAs in humans (ca. 40–50%) originated in the phylogenetic grouping defined as primates. The dynamic evolution of this family of non-coding RNA is further demonstrated by the presence of microRNA unique to the human species. Investigations into the role of microRNA in cancer have until recently mainly focused on the more ancient members of this RNA family that are widely conserved in the animal kingdom. As I describe i... περισσότερα »
Difference between Hospital Pregnancy Test and Home Pregnancy Test?
Difference between Hospital Pregnancy Test and Home Pregnancy Test?: If you think you are pregnant or undergoing some symptoms of pregnancy, In that case now you have to take pregnancy test. So now here lies the confusion as to which pregnancy test to prefer? There are many pregnancy testing options available and one of the most convenient and accurate test is to take an at-home pregnancy test that requires your urine for the pregnancy hormones (hCG) to check whether you are pregnant or not. Another option is to visit your family doctor or nearest hospital to take a hospital pregna... περισσότερα »
Ku80 and PDGFR-α in nasal NK/T-cell lymphoma
Expression and significance of via ScienceDirect Publication: Pathology - Research and Practice Publication date: Available online 31 December 2015 *Source:*Pathology - Research and Practice Author(s): Jun Li, Ping Chen, Wei Liu, Zian Xia, Feng Shi, Meizuo Zhong BackgroundTo investigate the clinical and prognostic significance of Ku80 and PDGFR-α in nasal type NK/T cell lymphoma (NKTCL).MethodsImmunohistochemistry for Ku80 and PDGFR-α was performed on tissue sections from 35 patients diagnosed with NKTCL. We analyzed the relationship between Ku80 and PDGFR-α expression and the clinico... περισσότερα »
Chondroid syringoma of the axilla
Chondroid syringoma of the axilla: An unusual tumor diagnosed by fine needle aspiration: Background Chondroid syringoma (CS) is a rare benign adnexal tumor of the skin with a resemblance to pleomorphic adenoma of salivary gland, most commonly involving the head and neck region. In the present literature, reports of the cytologic appearance of CS are scarce as it is rarely encountered by fine needle aspiration (FNA). Case Presentation A 67-year-old woman presented with a 1 year history of a 1 cm subcutaneous nodule in the right axilla. FNA biopsy was performed revealing an epithelia... περισσότερα »
An analysis of human papillomavirus testing and endocervical component on pap tests: A pilot study using the Roche Cobas® assay
An analysis of human papillomavirus testing and endocervical component on pap tests: A pilot study using the Roche Cobas® assay: Introduction HPV is known to have a predilection for infecting the transformation zone (TZ). Endocervical cells (EC) on a Pap test (PT) indicate that the cervical TZ has been sampled. [deleted: Evidence has shown that] Earlier repeat testing of women lacking EC is of little value in further detecting disease, thus a sample without EC is not necessarily inadequate. Both HPV testing and PT can be performed using a single sample; however, few studies have in...περισσότερα »
Cytological findings of odontogenic myxofibroma: A diagnostic dilemma
Cytological findings of odontogenic myxofibroma: A diagnostic dilemma: Odontogenic myxofibroma represents a rare slow-growing benign neoplasm, which usually occurs in the second and third decades of life and rarely in children or adults over 50 years of age. Myxomas in general represent from 2.3% to 17.7% of all odontogenic tumors, and myxofibromas represent a small number of all myxomas. Limited evidence is present in literature regarding the cytological diagnosis of odontogenic myxoma/myxofibroma. We hereby report the cytomorphological features of a histologically confirmed case o... περισσότερα »
Case-control study of GRIA1 and GRIA3 gene variants in migraine
Case-control study of GRIA1 and GRIA3 gene variants in migraine: Background: As the most abundant excitatory neurotransmitter in the central nervous system, glutamate has been accepted to play a major role in the pathophysiology of migraine. The previous studies have reported the glutamate receptor ionotropic GRIA1 and GRIA3 genes variants associated with migraine. The project aims to investigate the polymorphisms in both genes for their association with migraine in the Chinese Han population. Methods: A Han-Chinese case-control population, including 331 unrelated female migraine pati...περισσότερα »
Right middle lobe atelectasis in children with asthma
Right middle lobe atelectasis in children with asthma and prognostic factors via Allergology International Publication date: Available online 22 January 2016 *Source:*Allergology International Author(s): Ozge Soyer, Cinar Ozen, Ozlem Cavkaytar, Cagri Senyücel, Yildiz Dallar BackgroundAlthough right middle lobe (RML)-atelectasis of the lungs is a common complication of asthma, the relevant data is limited. The aim of this study is to define the characteristics of RML atelectasis in asthma during childhood.MethodsChildren with asthma who had recently developed RML atelectasis were includ...περισσότερα »
Aflatoxin B1-induced injury
Changes in serum cytokine levels, hepatic and intestinal morphology in aflatoxin B1-induced injury: modulatory roles of melatonin and flavonoid-rich fractions from Chromolena odorata: AbstractAflatoxins are known to produce chronic carcinogenic, mutagenic, and teratogenic effects, as well as acute inflammatory effects, especially in the gastrointestinal tract. The potentials of the flavonoid-rich extract from *Chromolena odorata* (FCO) and melatonin (a standard anti-oxidant and anti-inflammatory agent) against aflatoxin B1 (AFB1)-induced alterations in pro-inflammatory cytokine lev... περισσότερα »
Risk Factors and Comorbidities in Chronic Rhinosinusitis
Risk Factors and Comorbidities in Chronic Rhinosinusitis: AbstractChronic rhinosinusitis (CRS) is a heterogeneous disorder that creates a significant burden on the healthcare system. It is caused by a combination of inflammatory, environmental, and host factors; however, the precise mechanism of how each factor leads to CRS continues to be a source of debate. Previous data regarding this topic is often inconsistent or of lower quality. In this article, we review the recent literature on the risk factors and comorbidities in CRS. Large population-based studies have helped establish ... περισσότερα »
Coffee consumption and the risk of cirrhosis
Systematic review with meta-analysis: coffee consumption and the risk of cirrhosis: Summary Background Liver cirrhosis is a large burden on global health, causing over one million deaths per year. Observational studies have reported an inverse association between coffee and cirrhosis. Aims To perform a systematic review and meta-analysis to characterise the relationship between coffee consumption and cirrhosis. Methods We searched for studies published until July 2015 that reported odds ratios, relative risks (RR) or hazard ratios for cirrhosis stratified by coffee consumption. We c... περισσότερα »
Comparison of manually crimping and laser-activated nitinol prosthesis in otosclerosis surgery: our experience of 98 patients
Comparison of manually crimping and laser-activated nitinol prosthesis in otosclerosis surgery: our experience of 98 patients: Abstract Stapedotomy with either K-Piston or NiTiBOND prosthesis was safe and successful for treating otosclerosis in our material of 105 ears (K-Piston, 71 ears; NiTiBOND, 34 ears). Hearing outcome was similar with both prostheses: the air-bone-gap was 5.4 ± 0.9 dB for K-Piston and 4.8 ± 1.3 dB for NiTiBOND. With both prostheses the postoperative air-bone-gap was 10 dB or less in over 80% of the operated ears. Complications were minor, and complication rates... περισσότερα »
Pharyngeal pouch management: an historical review
Review ArticlesPharyngeal pouch management: an historical reviewK Stewarta1 c1 and P Sena2 a1 Department of Otolaryngology, James Cook University Hospital, Middlesbrough, UK a2 Department of Otolaryngology, Whipps Cross University Hospital, London, UK Abstract Background: Management of the pharyngeal pouch has evolved enormously since the first description by Ludlow in 1764 and the first case series by Zenker and Von Ziemssen in 1877. With the introduction of antibiotics, and the advancement of surgical technique with the advent of endoscopic surgery and lasers, current management is... περισσότερα »
Cochlear involvement in patients with ulcerative colitis
Main ArticlesCochlear involvement in patients with ulcerative colitisM Sagit a1 c1, S Gulera2, A Karamana3, M Yasara1, A Emiroglua1 and I Ozcana1 a1 Department of ENT, Kayseri Training and Research Hospital, Turkey a2 Department of ENT, Balıkesir Bigadic Government Hospital, Turkey a3 Department of Gastroenterology, Kayseri Acıbadem Hospital, Turkey Abstract Objective: To investigate whether cochlear involvement is an extraintestinal manifestation in patients with ulcerative colitis. Method: Forty-four ulcerative colitis patients and 44 age-matched healthy subjects were included in the st...περισσότερα »
Optimal ileocolic flap length for a reconstructed voice tube after laryngopharyngectomy
Main ArticlesOptimal ileocolic flap length for a reconstructed voice tube after laryngopharyngectomyY-A Tsoua1, T-S Lia2, M-H Tsaia1, H-C Chena2 c1 and P Belafskya3 a1 Department of Otolaryngology Head and Neck Surgery, China Medical University Hospital, Taichung, Taiwan a2 Department of Plastic Surgery, China Medical University Hospital, Taichung, Taiwan a3 Voice and Swallow Center, University of California, Davis, USA Abstract Background: Voice restoration after laryngopharyngectomy can be achieved with an autologous ileocolic flap. We have observed that the length of the flap influ...περισσότερα »
Spontaneous closure of traumatic tympanic membrane perforations: observational study
Spontaneous closure of traumatic tympanic membrane perforations: observational study: Letter Z C Lou, The Journal of Laryngology & Otology, Volume 130 Issue 02
Obliquity of the stapes in otosclerosis: intra-operative observations and implications in stapes surgery
Main ArticlesObliquity of the stapes in otosclerosis: intra-operative observations and implications in stapes surgeryV Ananda1 c1 and H N Udayabhanua1 a1 Department of Otorhinolaryngology and Head and Neck Surgery, MCV Memorial ENT Trust Hospital, Pollachi, Tamil Nadu, India Abstract Objective: To establish the prevalence of stapes obliquity as observed in otosclerosis patients during stapes surgery by a simple method of intra-operative measurement. Design: Prospective observational study. Results: Intra-operative measurements showed that the mean distance (± standard deviation) betwe... περισσότερα »
Top-cited articles of the last 30 years (1985–2014) in otolaryngology – head and neck surgery
Review ArticlesTop-cited articles of the last 30 years (1985–2014) in otolaryngology – head and neck surgeryR Lenzia1 c1, S Fortunatoa2 and L Muscatelloa1 a1 Division of Otorhinolaryngology, S.S. Giacomo e Cristoforo General Hospital, Massa, Italy a2 Division of Otolaryngology-Audiology and Phoniatrics, University of Pisa, Italy Abstract Background: The frequency with which a scientific article is cited by other studies is one way to measure its academic influence. Methods: A comprehensive search was performed to identify journal articles in the otorhinolaryngology subject category of...περισσότερα »
Introducing a realistic and reusable quinsy simulator
Short CommunicationIntroducing a realistic and reusable quinsy simulator N Gibletta1 c1 and C Haria1 a1 Department of Otolaryngology, Princess Royal Hospital, Telford, UK Abstract Background: An increasing number of inexperienced doctors are rotating through otolaryngology departments and providing care to ENT patients. Numerous acute ENT conditions require basic surgical or technical intervention; hence, effective and efficient simulation induction training has become paramount in providing a safe yet valuable educational environment for the junior clinician. Whilst simulation has dev... περισσότερα »
Local anaesthesia and conscious sedation for cochlear implantation: experience with 20 patients
Main ArticlesLocal anaesthesia and conscious sedation for cochlear implantation: experience with 20 patientsB Paterona1 c1, D Bakhosa1a2, A LeLouarna3, P Bordurea4, A Bozorg Grayelia5, B Godeya6and E Lescannea1a2 a1 Otorhinolaryngology and Head and Neck Surgery Department, University Hospital Center of Tours, France a2 Joint Research Unit (French National Institute of Health and Medical Research – Unit 930, and French National Center for Scientific Research – Accredited Research Team 3106), François Rabelais University Hospital Center of Tours, France a3 Medical Information, Epidemiol... περισσότερα »
Prognostic value of mean platelet volume on tinnitus
Main ArticlesPrognostic value of mean platelet volume on tinnitusO Kemala1 c1, T Müderrisa2, F Başara1, G Kutlara1 and F Güla2 a1 Otolaryngology Department, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey a2 Otolaryngology Department, Ankara Atatürk Education and Research Hospital, Turkey Abstract Objective: This study aimed to determine whether there was any relationship between tinnitus and mean platelet volume. Methods: This retrospective study was conducted between January 2013 and January 2014 in Ankara Atatürk Hospital and Ondokuz Mayıs University Hospital, Turkey,... περισσότερα »
Comparison of three diagnostic tests in detecting vestibular deficit in patients with peripheral vestibulopathy
Main ArticlesComparison of three diagnostic tests in detecting vestibular deficit in patients with peripheral vestibulopathyP Eza-Nuñeza1, C Fariñas-Alvareza2 and N Perez Fernandeza3 c1 a1 Department of Otorhinolaryngology, Hospital Sierrallana, Cantabria, Spain a2 Health Care Quality Unit, Hospital Marques de Valdecilla, Santander, Spain a3 Department of Otorhinolaryngology, Clínica Universidad de Navarra, University Hospital and Medical School – University of Navarra, Pamplona, Spain Abstract Objectives: This study aimed to evaluate the results of the video head impulse test and of ...περισσότερα »
How advances in light technology have shaped ENT
Review ArticlesHow advances in light technology have shaped ENTM Mozaffaria1 c1, J M Fishmana1a2 and N S Tolleya1 a1 ENT Department, St Mary's Hospital, London, UK a2 ENT Department, University College London, UK Abstract The development of light technologies, allowing anatomical visualisation of otherwise hidden structures, led to significant advances in ENT in the nineteenth and twentieth centuries. Natural light from the sun, and from candles, was initially harnessed using mirrors. Later, the invention of limelight and electricity preceded the emergence of the modern-day endoscope,... περισσότερα »
Simultaneous cochlear implantation and labyrinthectomy for advanced Ménière's disease
Clinical RecordsSimultaneous cochlear implantation and labyrinthectomy for advanced Ménière's diseaseR L Heywooda1a2 c1 and M D Atlasa1a2 a1 Sir Charles Gairdner Hospital, Perth, Australia a2 Ear Science Institute Australia, Perth, Australia Abstract Background: Patients with Ménière's disease can develop unaidable sensorineural hearing loss. Cochlear implantation has recently been utilised in this group with favourable results. A more challenging group are those with intractable vertigo, and they have traditionally posed a significant management dilemma. Case report: Two female patien...περισσότερα »
Alterations of mucosa of the larynx and hypopharynx in patients with mucopolysaccharidoses
Main ArticlesAlterations of mucosa of the larynx and hypopharynx in patients with mucopolysaccharidosesA Keilmanna1 c1, F Bendela2, S Nospesa2, C Lampea3 and A K Läßiga2 a1 Voice Care Center, Bad Rappenau, Germany a2 Division of Communication Disorders, Department of ORL, University Medical Center, Mainz, Germany a3 Center for Rare Diseases, Department of Child and Adolescent Medicine, Horst Schmidt Klinik, Wiesbaden, Germany Abstract Objective: This study aimed to: assess the mucosal alterations of the larynx and hypopharynx typical for mucopolysaccharidoses, in a standardised manner... περισσότερα »
Giant basal cell carcinoma of the face
Main ArticlesGiant basal cell carcinoma of the face: surgical management and challenges for reconstructionA Maimaitia1a2, A Mijitia1a2, A Yarbaga3 and A Mominga1a2 c1 a1 Department of Oral and Maxillofacial Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China a2 Stomatological Research Institute of Xinjiang Uyghur Autonomous Region, Urumqi, Xinjiang, People's Republic of China a3 Marmara Eye Center, Sakarya, Turkey Abstract Background: Giant basal cell carcinoma, in which the tumour measures 5 cm or greater in diameter, is a ve...περισσότερα »
Microbial causes of complicated acute bacterial rhinosinusitis and implications for empirical antimicrobial therapy
Main ArticlesMicrobial causes of complicated acute bacterial rhinosinusitis and implications for empirical antimicrobial therapyM S Miaha1, P Nixa1 c1, A Koukkoullisa1 and J Sandoea2 a1 Department of Otorhinolaryngology – Head and Neck Surgery, Leeds General Infirmary, UK a2 Department of Microbiology, Leeds General Infirmary, UK Abstract Objectives: Very little up-to-date information is available on the microbiology of complicated acute bacterial rhinosinusitis. Reliable microbiology testing is necessary to inform current empirical antimicrobial treatments. This study was conducted i...περισσότερα »
Demographic factors associated with loss to follow up in the management of chronic otitis media: case–control study
Main ArticlesDemographic factors associated with loss to follow up in the management of chronic otitis media: case–control studyR Nasha1 c1, R Foxa1, R Srinivasana1, A Majithiaa1 and A Singha1 a1 Department of Otolaryngology, Head and Neck Surgery, Northwick Park Hospital, Harrow, UK Abstract Objective: The likelihood of a patient attending regular follow up can affect decision making when planning and performing tympanomastoid surgery. This study investigated whether demographic factors were associated with loss to follow up. Methods: A database of patients who had been investigated ...περισσότερα »
Horner syndrome in glandular fever: a case report
Clinical RecordsHorner syndrome in glandular fever: a case reportE V Westa1 c1, F Sheerina2 and J E H M Batesa3 a1 Department of Plastic Surgery, Norfolk and Norwich University Hospitals, Norwich, UK a2 Department of Neuroradiology, Oxford University Hospitals NHS Trust, UK a3 Department of Plastic Surgery, Oxford University Hospitals NHS Trust, UK Abstract Objective: This study aimed to present and discuss the case of a patient with known glandular fever who presented with Horner syndrome. Case report: A 35-year-old patient with known glandular fever developed acute unilateral Horner s...περισσότερα »
ENT and airways in the emergency department
Main ArticlesENT and airways in the emergency department: national survey of junior doctors' knowledge and skillsK L Whitcrofta1 c1, B Mossa2 and A Mcraea1 a1 ENT Department, Lincoln County Hospital, UK a2 University of Nottingham Medical School, Queen's Medical Centre, UK Abstract Background: Given the urgent nature of ENT emergencies, appropriate knowledge is required amongst front-line staff. Junior doctors account for almost one quarter of emergency department doctors. It has been shown that undergraduate coverage of ENT is variable. This study therefore aimed to determine whether... περισσότερα »
Technology and ENT
Technology and ENT: Editorial Robin Youngs, Edward Fisher, Musheer Hussain, Jonathan Fishman, The Journal of Laryngology & Otology, Volume 130 Issue 02
Involvement of spinal α2-adrenoceptors in prolonged modulation of hind limb withdrawal reflexes following acute noxious stimulation in the anaesthetised rabbit
Abstract The role of spinal α2-adrenoceptors in mediating long-lasting modulation of hind limb withdrawal reflexes following acute noxious chemical stimulation of distant heterotopic and local homotopic locations has been investigated in pentobarbitone-anaesthetised rabbits. Reflexes evoked in the ankle extensor muscle medial gastrocnemius (MG) by electrical stimulation of the ipsilateral heel, and reflexes elicited in the ankle flexor tibialis anterior and the knee flexor semitendinosus by stimulation at the base of the ipsilateral toes, could be inhibited for over an hour after m... περισσότερα »
Model of anesthetic induction by unilateral intracerebral microinjection of GABAergic agonists
Abstract General anesthetic agents induce loss of consciousness coupled with suppression of movement, analgesia and amnesia. Although these diverse functions are mediated by neural structures located in wide-ranging parts of the neuraxis, anesthesia can be induced rapidly and reversibly by bilateral microinjection of minute quantities of GABAA-R agonists at a small, focal locus in the mesopontine tegmentum (MPTA). State switching under these circumstances is presumably executed by dedicated neural pathways and does not require widespread distribution of the anesthetic agent itself...περισσότερα »
The contribution of inner and outer retinal photoreceptors to infra-slow oscillations in the rat olivary pretectal nucleus
Abstract A subpopulation of olivary pretectal nucleus (OPN) neurons discharges action potentials in an oscillatory manner, with a period of approximately two minutes. This 'infra-slow' oscillatory activity depends on synaptic excitation originating in the retina. Signals from rod-cone photoreceptors reach the OPN via the axons of either classic retinal ganglion cells or intrinsically photosensitive retinal ganglion cells (ipRGCs), which use melanopsin for photon capturing. Although both cell types convey light information, their physiological functions differ considerably. The aim ... περισσότερα »
Validation of the Spanish Version of the Eating Assessment Tool-10 (EAT-10spa) in Colombia. A Blinded Prospective Cohort Study.
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
*Validation of the Spanish Version of the Eating Assessment Tool-10 (EAT-10spa) in Colombia. A Blinded Prospective Cohort Study.* Dysphagia. 2016 Jan 23; Authors: Giraldo-Cadavid LF, Gutiérrez-Achury AM, Ruales-Suárez K, Rengifo-Varona ML, Barros C, Posada A, Romero C, Galvis AM Abstract Dysphagia might affect 12 % of the general population, and its complications include pneumonia, malnutrition, social isolation, and death. No validated Spanish symptom survey exists to quantify dysphagia symptoms among Latin Americans. Therefore, we performed a prospective cohort study in a tert... περισσότερα »
Effects of expiratory muscle strength training on oropharyngeal dysphagia in subacute stroke patients: a randomised controlled trial.
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα
*Effects of expiratory muscle strength training on oropharyngeal dysphagia in subacute stroke patients: a randomised controlled trial.* J Oral Rehabil. 2016 Jan 24; Authors: Park JS, Oh DH, Chang MY, Kim KM Abstract Expiratory muscle strength training (EMST) involves forcible blowing as a means of generating high expiratory pressure, against adjustable resistance. EMST has recently been introduced as a potential treatment for dysphagia. This study was performed to investigate the effects of EMST on the activity of suprahyoid muscles, aspiration and dietary stages in stroke patie...περισσότερα »
Use of a Dedicated, Non-Physician Led Mental Health Team to Reduce Pediatric Emergency Department Lengths of Stay
[image: cover.gif?v=1&s=70e1ac73b46cda4b9dd2517c] Abstract Mental health (MH) disorders are common in children, with an estimated 13-20% of children in the United States experiencing a mental disorder in a given year.1-5 They also are increasing, with a reported 24% increase in inpatient MH and substance abuse admissions among children from 2007-2010,6 and an 80% increase in hospital stays for children with mood disorders from 1997-2010.7 Despite this increasing prevalence, psychiatric services for children in many parts of the country are limited,8 leaving many with unmet psychi...περισσότερα »
A Model Longitudinal Observation Medicine Curriculum for an Emergency Medicine Residency
Abstract The role of observation services for emergency department patients has increased in recent years. Driven by changing health care practices and evolving payer policies, many hospitals in the United States currently have or are developing an Observation Unit and emergency physicians are most often expected to manage patients in this setting. Yet, few residency programs dedicate a portion of their clinical curriculum to Observation Medicine. This knowledge set should be integrated into the core training curriculum of emergency physicians. Presented here is a model Observation...περισσότερα »
Vitamin B12 Deficiency in Infancy: The Case for Screening
[image: cover.gif?v=1&s=98eaac9aa01c26482474b8cd] The classic principles put forth by Wilson and Jungner are often applied to determine the suitability of a condition for universal newborn screening. The three cases described here portray the harmful effects of vitamin B12 deficiency in infancy. The challenges and opportunities of early recognition and treatment are highlighted. Screening newborns would allow early detection and prevention of severe neurological damage in vitamin B12-deficient infants and enable diagnosis of unrecognized maternal pernicious anemia in asymptomatic ... περισσότερα »
Validation of the Spanish Version of the Eating Assessment Tool-10 (EAT-10spa) in Colombia. A Blinded Prospective Cohort Study.
*Validation of the Spanish Version of the Eating Assessment Tool-10 (EAT-10spa) in Colombia. A Blinded Prospective Cohort Study.* Dysphagia. 2016 Jan 23; Authors: Giraldo-Cadavid LF, Gutiérrez-Achury AM, Ruales-Suárez K, Rengifo-Varona ML, Barros C, Posada A, Romero C, Galvis AM Abstract Dysphagia might affect 12 % of the general population, and its complications include pneumonia, malnutrition, social isolation, and death. No validated Spanish symptom survey exists to quantify dysphagia symptoms among Latin Americans. Therefore, we performed a prospective cohort study in a tert... περισσότερα »
Semi-Automated Counting of Axon Regeneration in Poly(Lactide Co-Glycolide) Spinal Cord Bridges
[image: alertIcon.gif] Publication date: Available online 25 January 2016 *Source:*Journal of Neuroscience Methods Author(s): Dylan A. McCreedy, Daniel J. Margul, Stephanie K. Seidlits, Jennifer T. Antane, Ryan J. Thomas, Gillian M. Sissman, Ryan M. Boehler, Dominique R. Smith, Sam W. Goldsmith, Todor V. Kukushliev, Jonathan B. Lamano, Bansi H. Vedia, Ting He, Lonnie D. Shea BackgroundSpinal cord injury (SCI) is a debilitating event with multiple mechanisms of degeneration leading to life-long paralysis. Biomaterial strategies, including bridges that span the injury and provide a pat...περισσότερα »
Microelectrode Array stimulation combined with Intrinsic Optical Imaging: A Novel tool for Functional brain Mapping
[image: alertIcon.gif] Publication date: Available online 25 January 2016 *Source:*Journal of Neuroscience Methods Author(s): Mykyta M. Chernov, Gang Chen, Luke A. Torre-Healy, Robert M. Friedman, Anna W. Roe BackgroundFunctional brain mapping via cortical microstimulation is a widely used clinical and experimental tool. However, data are traditionally collected point by point, making the technique very time consuming. Moreover, even in skilled hands, consistent penetration depths are difficult to achieve. Finally, the effects of microstimulation are assessed behaviorally, with no a... περισσότερα »
Pillars Article: Sequence Analysis of Peptides Bound to MHC Class II Molecules. Nature. 1991. 353: 622-627.
Authors: Rudensky AY, Preston-Hurlburt P, Hong SC, Barlow A, Janeway CA PMID: 26802059 [PubMed – in process] (Source: Journal of Immunology) from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Vkoqin via IFTTT
Impact of hydrogel spacer injections on interfraction prostate motion during prostate cancer radiotherapy.
Conclusions HS implantation does not significantly influence the interfraction prostate motion in patients treated with RT for prostate cancer. The major expected benefit of HS is a reduction of the high-dose levels to the rectal wall without influence in prostate immobilization. PMID: 26796870 [PubMed – as supplied by publisher] (Source: Acta Oncologica) from #Medicine-SfakianakisAlexandros via… Continue reading Impact of hydrogel spacer injections on interfraction prostate motion during prostate cancer radiotherapy.
Reassessing the Evolutionary Importance of Inflammasomes.
Authors: Maltez VI, Miao EA Abstract Inflammasomes monitor the cytosol for microbial contamination or perturbation and, thus, are predicted to provide potent defense against infection. However, the compendium of data from murine infection models suggests that inflammasomes merely delay the course of disease, allowing the host time to mount an adaptive response. Interpretations of such… Continue reading Reassessing the Evolutionary Importance of Inflammasomes.
Clinical Features and Prognosis of Generalized Lymphatic Anomaly, Kaposiform Lymphangiomatosis, and Gorham–Stout Disease
Background Complex lymphatic anomalies are intractable lymphatic disorders, including generalized lymphatic anomaly (GLA), Gorham–Stout disease (GSD), and kaposiform lymphangiomatosis (KLA). The etiology of these diseases remains unknown and diagnosis is confused by their similar clinical findings. This study aimed to clarify the differences in clinical features and prognosis among GLA, KLA, and GSD, in Japanese… Continue reading Clinical Features and Prognosis of Generalized Lymphatic Anomaly, Kaposiform Lymphangiomatosis, and Gorham–Stout Disease
A Century of Excellence: Celebrating 100 Years of The Journal of Immunology.
Authors: Fink PJ, Hogan MM, Kenyon KJ PMID: 26802057 [PubMed – in process] (Source: Journal of Immunology) from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1VkopuV via IFTTT
Pleiotropic Functions of H3K27Me3 Demethylases in Immune Cell Differentiation.
Authors: Bosselut R Abstract The trimethylation of histone H3 lysine 27 (H3K27Me3) contributes to gene repression, notably through recruitment of Polycomb complexes, and has long been considered essential to maintain cell identity. Whereas H3K27Me3 was thought to be stable and not catalytically reversible, the discovery of the Utx and Jmjd3 demethylases changed this notion, raising… Continue reading Pleiotropic Functions of H3K27Me3 Demethylases in Immune Cell Differentiation.
‘Complementary & Alternative Medicine’ (CAM): Ethical And Policy Issues
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1lJXHzN via IFTTT
The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer.
In this study, the crystal structure of H-2D(b) in complex with the first identified TEIPP Ag (MCLRMTAVM) derived from the Trh4 protein has been determined to 2.25 Å resolution. In contrast to prototypic H-2D(b) peptides, Trh4 takes a noncanonical peptide-binding pattern with extensive sulfur-π interactions that contribute to the overall complex stability. Importantly, the noncanonical… Continue reading The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer.
No Understanding, No Consent: The Case Against Alternative Medicine
Abstract The demand for informed consent in clinical medicine is usually justified on the basis that it promotes patient autonomy. In this article I argue that the most effective way to promote autonomy is to improve patient understanding in order to reduce the epistemic disparity between patient and medical professional. Informed consent therefore derives its… Continue reading No Understanding, No Consent: The Case Against Alternative Medicine
Alternative Medicine and the Ethics Of Commerce
Abstract Is it ethical to market complementary and alternative medicines? Complementary and alternative medicines (CAM) are medical products and services outside the mainstream of medical practice. But they are not just medicines (or supposed medicines) offered and provided for the prevention and treatment of illness. They are also products and services – things offered for… Continue reading Alternative Medicine and the Ethics Of Commerce
Body representation in the brain
[image: alertIcon.gif] Publication date: Available online 25 January 2016 *Source:*Neuroscience Research Author(s): Eiichi Naito, Jun Ota, Akira Murata from Neurology via xlomafota13 on Inoreader http://ift.tt/1KzwDcV via IFTTT
Consequences of a false-positive mammography result: drug consumption before and after screening.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 57 δευτερόλεπτα
Conclusion(s) Drugs used to mitigate mood disorders were used more frequently by women with false-positive than by women with normal mammograms already before the screening event, while the changes from before to after screening were similar for both groups. The results point to the importance of control for potential selection in studies of screening effects. […]
Impact of hydrogel spacer injections on interfraction prostate motion during prostate cancer radiotherapy.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 57 δευτερόλεπτα
Conclusions HS implantation does not significantly influence the interfraction prostate motion in patients treated with RT for prostate cancer. The major expected benefit of HS is a reduction of the high-dose levels to the rectal wall without influence in prostate immobilization. PMID: 26796870 [PubMed – as supplied by publisher] (Source: Acta Oncologica) from #Medicine-SfakianakisAlexandros via […]
Improvements in breast cancer survival between 1995 and 2012 in Denmark: The importance of earlier diagnosis and adjuvant treatment.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 57 δευτερόλεπτα
Conclusion The impact of screening was by nature of limited magnitude. The modified treatment strategies implemented by the use of nationwide guidelines seemed to have a major impact on the substantial survival improvements. PMID: 26797010 [PubMed – as supplied by publisher] (Source: Acta Oncologica) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QnN68x via IFTTT Medicine by […]
Vitamin B12 Deficiency in Infancy: The Case for Screening
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 57 δευτερόλεπτα
The classic principles put forth by Wilson and Jungner are often applied to determine the suitability of a condition for universal newborn screening. The three cases described here portray the harmful effects of vitamin B12 deficiency in infancy. The challenges and opportunities of early recognition and treatment are highlighted. Screening newborns would allow early detection […]
Clinical Features and Prognosis of Generalized Lymphatic Anomaly, Kaposiform Lymphangiomatosis, and Gorham–Stout Disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 57 δευτερόλεπτα
Background Complex lymphatic anomalies are intractable lymphatic disorders, including generalized lymphatic anomaly (GLA), Gorham–Stout disease (GSD), and kaposiform lymphangiomatosis (KLA). The etiology of these diseases remains unknown and diagnosis is confused by their similar clinical findings. This study aimed to clarify the differences in clinical features and prognosis among GLA, KLA, and GSD, in Japanese […]
Short-Interval Retreatment With Stereotactic Body Radiotherapy (SBRT) for Pediatric Neuroblastoma Resulting in Severe Myositis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 57 δευτερόλεπτα
We report a severe and not previously reported toxicity after short-interval retreatment with stereotactic body radiotherapy (SBRT) in a pediatric patient with neuroblastoma. This patient experienced Grade III radiation myositis after treatment with conventional radiation therapy followed by high-dose SBRT for persistent disease a short interval after the initial radiotherapy course. While SBRT shows outstanding […]
Volume 130 Issue 02
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The Journal of Laryngology & Otology, Volume 130 Issue 02 The Journal of Laryngology & Otology ( JLO ) is a leading monthly journal containing original scientific articles and clinical records in otology, rhinology, laryngology and related specialities. Founded in 1887, JLO is absorbing reading for ENT specialists and trainees. The journal has an international […]
Technology and ENT
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Editorial Robin Youngs, Edward Fisher, Musheer Hussain, Jonathan Fishman, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 111-111 Abstract from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1ntMZix via IFTTT
Glue ear: how good is the information on the World Wide Web?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Research Articles L Ritchie, C Tornari, P M Patel, R Lakhani, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 157-161 Abstract from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1lK0rNx via IFTTT
OTOLARYNGOLOGY – HEAD AND NECK SURGERY: RAPID CLINICAL AND BOARD REVIEW M L Carlson, K M Van Abel, D J Archib ald, D L Price Thieme Publishers, 2015 ISBN 978 1 60406 768 2 pp 456 Price €(D)109.99 CHF 154.00
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Book Reviews L M Flood, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 211-211 Abstract from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1ntMZ27 via IFTTT
THE NOSE – REVISION & RECONSTRUCTION: A MANUAL AND CASEBOOK H Behrbohm Thieme Publishers, 2015 ISBN 978 3 13143 591 0 eISBN 978 3 13150 511 8 pp 304 Price US$159.99 €139.99
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Book Reviews C Hopkins, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 212-212 Abstract from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1ZN3EJw via IFTTT
ENT and airways in the emergency department: national survey of junior doctors’ knowledge and skills
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Research Articles K L Whitcroft, B Moss, A Mcrae, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 183-189 Abstract from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1ZN3Etc via IFTTT
Horner syndrome in glandular fever: a case report
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Rapid Communication E V West, F Sheerin, J E H M Bates, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 207-209 Abstract from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1PvoRYU via IFTTT
Demographic factors associated with loss to follow up in the management of chronic otitis media: case–control study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Research Articles R Nash, R Fox, R Srinivasan, A Majithia, A Singh, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 166-168 Abstract from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1ZN3EsZ via IFTTT
Microbial causes of complicated acute bacterial rhinosinusitis and implications for empirical antimicrobial therapy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Research Articles M S Miah, P Nix, A Koukkoullis, J Sandoe, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 169-175 Abstract from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1PvoPQP via IFTTT
Giant basal cell carcinoma of the face: surgical management and challenges for reconstruction
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Research Articles A Maimaiti, A Mijiti, A Yarbag, A Moming, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 176-182 Abstract from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1ZN3C4D via IFTTT
Comparison of clinical and radiographic status around dental implants placed in patients with and without prediabetes: 1-year follow-up outcomes
[image: cover.gif?v=1&s=be74442fea687c39b7fdfa63] Abstract Objective We hypothesized that peri-implant soft tissue inflammation is worse and peri-implant marginal bone loss (MBL) is higher around dental implants placed in patients with prediabetes compared to healthy subjects. The aim of the present 12-month follow-up study was to compare the clinical and radiographic status around dental implants placed in patients with and without prediabetes. Material and methods Twelve patients with medically diagnosed prediabetes (Group-1) and 12 controls (Group-2) were included. All patie... περισσότερα »
Giant basal cell carcinoma of the face: surgical management and challenges for reconstruction
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Research Articles A Maimaiti, A Mijiti, A Yarbag, A Moming, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 176-182 Abstract from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1ZN3C4D via IFTTT
Alterations of mucosa of the larynx and hypopharynx in patients with mucopolysaccharidoses
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Research Articles A Keilmann, F Bendel, S Nospes, C Lampe, A K Läßig, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 194-200 Abstract from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1PvoOwn via IFTTT
Simultaneous cochlear implantation and labyrinthectomy for advanced Ménière’s disease
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Rapid Communication R L Heywood, M D Atlas, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 204-206 Abstract from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1ZN3BgX via IFTTT
How advances in light technology have shaped ENT
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Review Articles M Mozaffari, J M Fishman, N S Tolley, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 112-115 Abstract from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1PvoNZt via IFTTT
Comparison of three diagnostic tests in detecting vestibular deficit in patients with peripheral vestibulopathy
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Research Articles P Eza-Nuñez, C Fariñas-Alvarez, N Perez Fernandez, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 145-150 Abstract from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1ZN3B0o via IFTTT
Prognostic value of mean platelet volume on tinnitus
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Research Articles O Kemal, T Müderris, F Başar, G Kutlar, F Gül, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 162-165 Abstract from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1ZN3AK1 via IFTTT
Local anaesthesia and conscious sedation for cochlear implantation: experience with 20 patients
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Research Articles B Pateron, D Bakhos, A LeLouarn, P Bordure, A Bozorg Grayeli, B Godey, E Lescanne, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 151-156 Abstract from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1ZN3AJV via IFTTT
Introducing a realistic and reusable quinsy simulator
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Rapid Communication N Giblett, C Hari, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 201-203 Abstract from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1PvoNbS via IFTTT
Top-cited articles of the last 30 years (1985–2014) in otolaryngology – head and neck surgery
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Review Articles R Lenzi, S Fortunato, L Muscatello, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 121-127 Abstract from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1PvoLk7 via IFTTT
Obliquity of the stapes in otosclerosis: intra-operative observations and implications in stapes surgery
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Research Articles V Anand, H N Udayabhanu, The Journal of Laryngology & Otology, Volume 130 Issue 02, pp 134-144 Abstract from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1PvoL3F via IFTTT
Observers' Agreement on Measurements in Fiberoptic Endoscopic Evaluation of Swallowing.
*Observers' Agreement on Measurements in Fiberoptic Endoscopic Evaluation of Swallowing.* Dysphagia. 2016 Jan 23; Authors: Pilz W, Vanbelle S, Kremer B, van Hooren MR, van Becelaere T, Roodenburg N, Baijens LW Abstract This study analyzed the effect that dysphagia etiology, different observers, and bolus consistency might have on the level of agreement for measurements in FEES images reached by independent versus consensus panel rating. Sixty patients were included and divided into two groups according to dysphagia etiology: neurological or head and neck oncological. All patien...περισσότερα »
Pneumolysin plays a key role at the initial step of establishing pneumococcal nasal colonization.
*Pneumolysin plays a key role at the initial step of establishing pneumococcal nasal colonization.* Folia Microbiol (Praha). 2016 Jan 23; Authors: Hotomi M, Yuasa J, Briles DE, Yamanaka N Abstract Nasopharyngeal colonization by Streptococcus pneumoniae is an important initial step for the subsequent development of pneumococcal infections. Pneumococci have many virulence factors that play a role in colonization. Pneumolysin (PLY), a pivotal pneumococcal virulence factor for invasive disease, causes severe tissue damage and inflammation with disruption of epithelial tight junction... περισσότερα »
Management and prevention of acute bleedings in the head and neck area with interventional radiology.
*Management and prevention of acute bleedings in the head and neck area with interventional radiology.* Head Face Med. 2016;12(1):6 Authors: Storck K, Kreiser K, Hauber J, Buchberger AM, Staudenmaier R, Kreutzer K, Bas M Abstract BACKGROUND: The Interventional Neuroradiology is becoming more important in the interdisciplinary treatment of acute haemorrhages due to vascular erosion and vascular tumors in the head and neck area. The authors report on acute extracranial haemorrhage in emergency situations but also on preventive embolization of good vascularized tumors preoperativel... περισσότερα »
Adenoid cystic carcinoma of the larynx presenting with unusual subglottic mass: Case report.
*Adenoid cystic carcinoma of the larynx presenting with unusual subglottic mass: Case report.* Auris Nasus Larynx. 2016 Jan 20; Authors: Kashiwagi T, Kanaya H, Konno W, Goto K, Hirabayashi H, Haruna SI Abstract A 33-year-old woman presented with an unusual subglottic bulging mass accompanied by prolonged cough and wheeze. Laryngeal endoscopy revealed a bilateral, symmetrical mass immediately below the vocal cords with marked airway obstruction. Chronic subglottic laryngitis with inflammation or another condition such as amyloidosis was initially suspected. Cervicothoracic comput... περισσότερα »
Telocytes in ileum of the Chinese giant salamander: ultrastructural evidence
Abstract Telocytes (TCs) and their telopodes (Tps) have been found in various organs of many mammals, including in lower animals. However, knowledge of TCs in lower animals is still very limited. This study identified TCs and their Tps in the ileum of the Chinese giant salamander, *Andrias davidianus* (Amphibia: Caudata), by transmission electron microscopy. The TCs/Tps were found near epithelial cells, glandular cells and unmyelinated nerve fibres. Moreover, exosomes were also found to be present in between TCs/Tps and these cells. from Cell via ola Kala on Inoreader http://ift.... περισσότερα »
Interleukin-1B 31 C>T polymorphism combined with Helicobacter pylori-modified gastric cancer susceptibility: evidence from 37 studies
Abstract Gastric cancer is one of the most common malignancies worldwide. Interleukin-1-beta (IL-1β) is a pro-inflammatory cytokine and potent inhibitor of gastric acid secretion. Some studies provided evidence of the association between *IL-1B* 31 polymorphism and gastric cancer risk while other studies did not. Therefore, we conducted a comprehensive meta-analysis to reassess the association. A systematic literature search of the PubMed and EMBASE databases identified 37 studies with 6108 cases and 8980 controls for this meta-analysis. The crude odd ratios (ORs) and the 95% conf...περισσότερα »
New editors in chief for the European Archives of Oto-Rhino-Laryngology.
*New editors in chief for the European Archives of Oto-Rhino-Laryngology.* Eur Arch Otorhinolaryngol. 2016 Jan 23; Authors: Olofsson J PMID: 26803307 [PubMed - as supplied by publisher] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1Vkk3nG via IFTTT
HAPCAD: An open-source tool to detect PCR crossovers in next-generation sequencing generated HLA data.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Authors: McDevitt SL, Bredeson JV, Roy SW, Lane JA, Noble JA Abstract Next-generation sequencing (NGS) based HLA genotyping can generate PCR artifacts corresponding to IMGT/HLA Database alleles, for which multiple examples have been observed, including sequence corresponding to the HLA-DRB1∗03:42 allele. Repeat genotyping of 131 samples, previously genotyped as DRB1∗03:01 homozygotes using probe-based methods, resulted […]
Characterisation and functional implications of the two new HLA-G alleles found in Amerindian and Caribbean populations.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Authors: Arnaiz-Villena A, Enriquez-de-Salamanca M, Palacio-Grüber J, Campos C, Camacho A, Martin-Villa JM, Martinez-Quiles N, Gomez-Casado E, Muñiz E Abstract HLA-G polymorphism has been found to be relatively low in all world populations. In the present paper two new HLA-G molecules are described in ancient American natives. A new HLA-G molecule from a Ecuador Amerindian […]
The prognostic impact of soluble and vesicular HLA-G and its relationship to circulating tumor cells in neoadjuvant treated breast cancer patients.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Authors: König L, Kasimir-Bauer S, Hoffmann O, Bittner AK, Wagner B, Manvailer LF, Schramm S, Bankfalvi A, Giebel B, Kimmig R, Horn PA, Rebmann V Abstract The non-classical human leukocyte antigen G (HLA-G) molecule and its soluble forms exert multiple immune suppressive regulatory functions in malignancy and in stem cells contributing to immune escape mechanisms. […]
Chimeric antigen receptor-redirected T cells return to the bench.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Authors: Geldres C, Savoldo B, Dotti G Abstract While the clinical progress of chimeric antigen receptor T cell (CAR-T) immunotherapy has garnered attention to the field, our understanding of the biology of these chimeric molecules is still emerging. Our aim within this review is to bring to light the mechanistic understanding of these multi-modular receptors […]
Antioxidants, Vol. 5, Pages 5: Acknowledgement to Reviewers of Antioxidants in 2015
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The editors of Antioxidants would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015. […] from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1S5q7mk via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The effect of mucoadhesive excipient on the nasal retention time of and the antibody responses induced by an intranasal influenza vaccine.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
CONCLUSION: CVP increased intranasal retention of whole inactivated influenza vaccine, did not promote antigen redirection to the central nervous system, and improved mucosal antibody responses. The mechanism probably relates to its mucoadhesive properties rather than its ability to directly stimulate the immune system. Intranasal vaccines with CVP may be a promising candidate vaccine formulation for […]
An initial examination of the potential role of T-cell immunity in protection against feline immunodeficiency virus (FIV) infection.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Authors: Aranyos AM, Roff SR, Pu R, Owen JL, Coleman JK, Yamamoto JK Abstract The importance of vaccine-induced T-cell immunity in conferring protection with prototype and commercial FIV vaccines is still unclear. Current studies performed adoptive transfer of T cells from prototype FIV-vaccinated cats to partial-to-complete feline leukocyte antigen (FLA)-matched cats a day before either […]
Benefits of using heterologous polyclonal antibodies and potential application to new and undertreated infectious pathogens.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
CONCLUSIONS: Polyclonal antibodies have been successfully applied to rabies, envenomation and intoxication. Polyclonal production provides an exciting opportunity to revolutionise the prognosis of both longstanding neglected tropical diseases as well as emerging infectious threats to humans. PMID: 26802604 [PubMed – as supplied by publisher] (Source: Vaccine) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RIoAlL via IFTTT […]
Evaluation of measles-rubella vaccination for mothers in early puerperal phase.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
CONCLUSION: MR vaccination in the early puerperal phase is considered an effective way to prevent the diseases, regardless of the mother’s immunological status and hormonal milieu. PMID: 26801065 [PubMed – as supplied by publisher] (Source: Vaccine) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ZN2qOu via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & […]
Surface display of a borrelial lipoprotein on meningococcal outer membrane vesicles.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Authors: Salverda ML, Meinderts SM, Hamstra HJ, Wagemakers A, Hovius JW, van der Ark A, Stork M, van der Ley P Abstract Outer Membrane Vesicles (OMVs) are gaining attention as vaccine candidates. The successful expression of heterologous antigens in OMVs, with the OMV functioning both as adjuvant and delivery vehicle, has greatly enhanced their vaccine […]
Understanding the Role of Cellular Molecular Clocks in Controlling the Innate Immune Response
The importance of the 24-h daily cycle, termed circadian, on immune function has been highlighted by a number of recent studies. Immune parameters such as the response to bacterial challenge or immune cell trafficking change with time of day and disruption of circadian rhythms has been linked to inflammatory pathologies. We are beginning to uncover… Continue reading Understanding the Role of Cellular Molecular Clocks in Controlling the Innate Immune Response
Methods to Investigate the Role of Toll-Like Receptors in Allergic Contact Dermatitis
Allergic contact disease is a common inflammatory skin disease resulting from hyperresponsiveness to harmless nonprotein substances such as metals, fragrances, or rubber. Recent research has highlighted a prominent role of Toll-like receptors, particularly TLR4 in contact allergen-induced innate immune activation that crucially contributes to the pathogenesis of this disease. (Source: Springer protocols feed by Immunology)… Continue reading Methods to Investigate the Role of Toll-Like Receptors in Allergic Contact Dermatitis
Delineating the Role of Toll-Like Receptors in the Neuro-inflammation Model EAE
Experimental autoimmune encephalomyelitis (EAE) is the most relevant and commonly used animal model to study autoimmune demyelinating diseases like Multiple Sclerosis (MS). In EAE, the activation of CD4+ T-cells is considered to be the main trigger leading to inflammation and central nervous system (CNS) demyelination. Toll-like receptors (TLRs) are the most important and first class… Continue reading Delineating the Role of Toll-Like Receptors in the Neuro-inflammation Model EAE
Analysis of Post-transcriptional Gene Regulation of Nod-Like Receptors via the 3′UTR
Innate immune signaling is the front line of defense against pathogens, leading to an appropriate response of immune cells upon activation of their pattern recognition receptors (PRRs) by microbial products, such as Toll-like receptors (TLRs). Apart from transcriptional control, gene expression in the innate immune system is also highly regulated at the post-transcriptional level. miRNA… Continue reading Analysis of Post-transcriptional Gene Regulation of Nod-Like Receptors via the 3′UTR
Methods for Delivering DNA to Intracellular Receptors
We describe here optimized procedures for both electroporation and chemical transfection, including the centrifugation of chemical transfection reagent onto cells, which greatly increases the speed and strength of responses. Appropriate choice of DNA and use of these methods allow study of either the cytosolic DNA responses in isolation or the simultaneous stimulation of cytosolic receptors… Continue reading Methods for Delivering DNA to Intracellular Receptors
Toll-Like Receptor Signalling and the Control of Intestinal Barrier Function
Epithelial barrier function and innate immunity are fundamental to the pathogenesis of inflammatory and infectious disease. Along with plasma membranes, epithelial cells are the primary cellular determinant of epithelial barrier function. The mechanism by which polarized epithelia form a permeability barrier is of fundamental importance to the prevention of many infectious and inflammatory diseases. Moreover,… Continue reading Toll-Like Receptor Signalling and the Control of Intestinal Barrier Function
Toll-Like Receptor Signalling and the Control of Intestinal Barrier Function
Epithelial barrier function and innate immunity are fundamental to the pathogenesis of inflammatory and infectious disease. Along with plasma membranes, epithelial cells are the primary cellular determinant of epithelial barrier function. The mechanism by which polarized epithelia form a permeability barrier is of fundamental importance to the prevention of many infectious and inflammatory diseases. Moreover,… Continue reading Toll-Like Receptor Signalling and the Control of Intestinal Barrier Function
Analysis of Post-transcriptional Gene Regulation of Nod-Like Receptors via the 3′UTR
Innate immune signaling is the front line of defense against pathogens, leading to an appropriate response of immune cells upon activation of their pattern recognition receptors (PRRs) by microbial products, such as Toll-like receptors (TLRs). Apart from transcriptional control, gene expression in the innate immune system is also highly regulated at the post-transcriptional level. miRNA… Continue reading Analysis of Post-transcriptional Gene Regulation of Nod-Like Receptors via the 3′UTR
Investigating the Role of Toll-Like Receptors in Models of Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation leading to tissue destruction and progressive loss of joint function. Here we describe two methods that can be used to assess the contribution of toll-like receptors (TLRs), and their potential ligands, to RA pathogenesis. We focus on the antigen-induced model of murine… Continue reading Investigating the Role of Toll-Like Receptors in Models of Arthritis
Simple Methods to Investigate MicroRNA Induction in Response to Toll-Like Receptors
In this chapter, we describe simple methods to investigate microRNA (miRNA) induction in response to lipopolysaccharide, the ligand for Toll-Like Receptor-4 activation. In brief, we demonstrate how to investigate global miRNA induction and/or repression in bone marrow-derived macrophages using TaqMan MicroRNA Arrays, followed by methods to measure individual miRNAs and target mRNA expression. Moreover, we… Continue reading Simple Methods to Investigate MicroRNA Induction in Response to Toll-Like Receptors
