Preventing Exertional Death in Military Trainees: Recommendations and Treatment Algorithms From a Multidisciplinary Working Group.
*Preventing Exertional Death in Military Trainees: Recommendations and Treatment Algorithms From a Multidisciplinary Working Group.* Mil Med. 2016 Apr;181(4):311-318 Authors: Webber BJ, Casa DJ, Beutler AI, Nye NS, Trueblood WE, O'Connor FG Abstract Despite aggressive prevention programs and strategies, nontraumatic exertional sudden death events in military training continue to prove a difficult challenge for the Department of Defense. In November 2014, the 559th Medical Group at Joint Base San Antonio-Lackland, Texas, hosted a working group on sudden exertional death in military...περισσότερα »
Findings From the Department of Veterans Affairs Qarmat Ali Medical Surveillance Program.
*Findings From the Department of Veterans Affairs Qarmat Ali Medical Surveillance Program.* Mil Med. 2016 Apr;181(4):307-310 Authors: Ciminera P, Superior MJ, Bullman T Abstract OBJECTIVE: To review the Veterans Affairs (VA) medical surveillance program for Veterans with potential hexavalent chromium (CrVI) exposure that occurred during 2003. METHODS: Retrospective review of medical records of the 124 Veterans that participated in standardized, in-person clinical evaluations for possible CrVI exposure during the incident in question. The evaluations were reviewed to define popula...περισσότερα »
Economic Burden of Hearing Loss for the U.S. Military: A Proposed Framework for Estimation.
*Economic Burden of Hearing Loss for the U.S. Military: A Proposed Framework for Estimation.* Mil Med. 2016 Apr;181(4):301-306 Authors: Alamgir H, Tucker DL, Kim SY, Betancourt JA, Turner CA, Gorrell NS, Wong NJ, Sagiraju HK, Cooper SP, Douphrate DI, Whitworth KW, Marko D, Gimeno D, Cornell J, Hammill TL, Senchak AJ, Packer MD Abstract The goal of this multiphased research is to develop methods to comprehensively determine the economic impact of hearing impairment and noise-induced hearing injury among active duty U.S. Service Members. Several steps were undertaken to develop a f... περισσότερα »
Refining waste hardmetals into tungsten oxide nanosheets via facile method
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Abstract A new hydrothermal system has been designed to recycle waste WC–Co hardmetal with low cobalt (Co) content (3 %). In the solution system, nitric acid was designed to dissolve Co, H2O2 served as oxidant to accelerate the oxidation of the WC–Co hardmetals, and fluorine (F−) was designed to dissolve and recrystallize generated tungsten oxides, […]
Oleate coating of iron oxide nanoparticles in aqueous systems: the role of temperature and surfactant concentration
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Abstract Coating magnetic nanoparticles (MNPs) with sodium oleate (SO) is known to be an excellent method to create biocompatible, stable colloids with a narrow size distribution. However, the mechanism of oleate adsorption on the MNP surface in aqueous systems, as well as its influence on colloidal stability, is not yet fully understood. In this context, […]
Electrochemical detection of copper ions leached from CuO nanoparticles in saline buffers and biological media using a gold wire working electrode
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Abstract We performed explorative cyclic voltammetry in phosphate-buffered saline buffers, Dulbecco’s modified Eagle’s medium (DMEM), and fetal bovine serum-added DMEM using Au wire as working electrode, both in the absence and in the presence of known nominal concentrations of Cu2+ ions or 15 nm CuO nanoparticles. Addition of either Cu2+ ions or aqueous suspension of […]
Gold nanoflowers with mesoporous silica as “nanocarriers” for drug release and photothermal therapy in the treatment of oral cancer using near-infrared (NIR) laser light
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Abstract In this experiment, we successfully developed nanocarriers in the form of gold nanoflowers coated with two layers of silica for the purposes of drug loading and NIR (near-infrared) photothermal therapy for the treatment of oral cancer. The gold nanoflowers converted NIR laser energy into heat energy. The cores were coated with a thin silica […]
Silica nanoparticles induce multinucleation through activation of PI3K/Akt/GSK-3β pathway and downregulation of chromosomal passenger proteins in L-02 cells
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Abstract Silica nanoparticles (SNPs) are applicable in various fields due to their unique physicochemical characteristics. However, concerns over their potential adverse effects have been raised. In our previous studies, we reported that SNPs could induce abnormal high incidence of multinucleation. The aim of this study is to further investigate the mechanisms of multinucleation induced by […]
Inhibition of BMP and of TGFβ receptors downregulates expression of XIAP and TAK1 leading to lung cancer cell death
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Bone morphogenetic proteins (BMP) are embryonic proteins that are part of the transforming growth factor (TGFβ) superfamily, which are aberrantly expressed in many carcinomas. Inhibition of BMP receptors with … (Source: Molecular Cancer) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1MTPtSo via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Association between oral fluoroquinolones and seizures: A self-controlled case series study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Objectives: The aim of this study was to investigate the association and to estimate the crude absolute risk of seizure among patients exposed to fluoroquinolones (FQs) in Hong Kong and the United Kingdom. Methods: A self-controlled case series study was conducted. Data were collected from the Hong Kong Clinical Data Analysis and Reporting System database […]
A randomized, controlled, double-blind, crossover trial of zonisamide in myoclonus-dystonia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Objective: To evaluate the efficacy and safety of zonisamide in patients with myoclonus-dystonia. Methods: We conducted a randomized, double-blind, placebo-controlled crossover trial of zonisamide (300 mg/d) in 24 patients with myoclonus-dystonia. Each treatment period consisted of a 6-week titration phase followed by a 3-week fixed-dose phase. The periods were separated by a 5-week washout period. […]
Lamotrigine use in pregnancy and risk of orofacial cleft and other congenital anomalies
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Objective: To test previous signals of a risk of orofacial cleft (OC) and clubfoot with exposure to the antiepileptic lamotrigine, and to investigate risk of other congenital anomalies (CA). Methods: This was a population-based case–malformed control study based on 21 EUROCAT CA registries covering 10.1 million births (1995–2011), including births to 2005 in which the […]
Tissue characterization using optical coherence tomography and cone beam computed tomography: A comparative pilot study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
To evaluate the ability of optical coherence tomography (OCT) in differentiating between human oral tissues in comparison with cone beam computed tomography (CBCT). from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RQvqBe via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The fat–fascia paddle only with a composite fibula flap: marked reduction in donor site morbidity
Fibula free flaps are used widely in head and neck reconstruction, primarily for their versatility and contribution to aesthetic and functional outcomes. The literature suggests that early complications such as wound dehiscence and skin graft loss can occur in up to a third of patients. The healing of these donor sites can be prolonged, and in certain cases may require an operative intervention. A method to overcome this problem is described herein. In raising the skin paddle, a standard lateral approach to the fibula harvest is used. from #ΓναθοΧειρουργική via xlomafota13 on Inor... περισσότερα »
Quality assessment of systematic reviews on alveolar socket preservation
The aim of this overview was to evaluate and compare the quality of systematic reviews, with or without meta-analysis, that have evaluated studies on techniques or biomaterials used for the preservation of alveolar sockets post tooth extraction in humans. An electronic search was conducted without date restrictions using the Medline/PubMed, Cochrane Library, and Web of Science databases up to April 2015. Eligibility criteria included systematic reviews, with or without meta-analysis, focused on the preservation of post-extraction alveolar sockets in humans. from #ΓναθοΧειρουργική ... περισσότερα »
Effect of Modified Constraint-Induced Movement Therapy Combined with Auditory Feedback for Trunk Control on Upper Extremity in Subacute Stroke Patients with Moderate Impairment: Randomized Controlled Pilot Trial
[image: yjscd2568-fig-0001.sml] The trunk compensatory strategy can impede the longer term functional recovery of the upper extremity (UE). The objective of this study is to investigate the effects of modified constraint-induced movement therapy (mCIMT) combined with auditory feedback for trunk control on UE function and activities of daily living among subacute stroke patients with moderate impairment. from Neurology via xlomafota13 on Inoreader http://ift.tt/1quhN4k via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/22eb...περισσότερα »
The Impact of Falls on Motor and Cognitive Recovery after Discharge from In-Patient Stroke Rehabilitation
[image: yjscd2555-fig-0001.sml] Falls are common among community-dwelling stroke survivors. The aims of this study were (1) to compare motor and cognitive outcomes between individuals who fell in the 6 months' postdischarge from in-patient stroke rehabilitation and those who did not fall, and (2) to explore potential mechanisms underlying the relationship between falls and recovery of motor and cognitive function. from Neurology via xlomafota13 on Inoreader http://ift.tt/1quhLcC via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://... περισσότερα »
Gender-Specific Association between Angiotensin II Type 2 Receptor −1332 A/G Gene Polymorphism and Advanced Carotid Atherosclerosis
The angiotensin II type 2 receptor (AT2R) −1332 A/G polymorphism has been denoted as functional and associated with certain cardiovascular disease phenotypes. However, there are no studies considering the association of this gene polymorphism with carotid atherosclerosis (CA) and cerebrovascular events. Therefore, the aim of our study was to investigate a possible association of the AT2R −1332 A/G polymorphism with the occurrence of carotid plaques (CPs) and history of cerebrovascular insult (CVI) in advanced CA. from Neurology via xlomafota13 on Inoreader http://ift.tt/1quhKWh vi... περισσότερα »
NAP SACC UK: protocol for a feasibility cluster randomised controlled trial in nurseries and at home to increase physical activity and healthy eating in children aged 2-4 years
Introduction Systematic reviews have identified the lack of intervention studies with young children to prevent obesity. This feasibility study examines the feasibility and acceptability of adapting the Nutrition and Physical Activity Self-Assessment for Child Care (NAP SACC) intervention in the UK to inform a full-scale trial. Methods and analysis A feasibility cluster randomised controlled trial in 12 nurseries in England, with 6 randomly assigned to the adapted NAP SACC UK intervention: nursery staff will receive training and support from an NAP SACC UK Partner to review the ... περισσότερα »
What drives quality improvement in chronic kidney disease (CKD) in primary care: process evaluation of the Quality Improvement in Chronic Kidney Disease (QICKD) trial
Objectives This study is a process evaluation of the Quality Improvement in Chronic Kidney Disease (QICKD) study, comparing audit-based education (ABE) and sending clinical guidelines and prompts (G&P) with usual practice, in improving systolic blood pressure control in primary care. This evaluation aimed to explore how far clinical staff in participating practices were aware of the intervention, and why change in practice might have taken place. Setting 4 primary care practices in England: 2 received ABE, and 2 G&P. We purposively selected 1 northern/southern/city and rural pra... περισσότερα »
Identification of a glucose-mannose phosphotransferase system in Clostridium beijerinckii
Effective uptake of fermentable substrates is a fundamentally important aspect of any fermentation process. The solventogenic bacterium *Clostridium beijerinckii* is noted for its ability to ferment a wide range of carbohydrates, yet few of its sugar transport systems have been characterized. In common with other anaerobes, *C. beijerinckii* shows a marked dependence on the PEP-dependent phosphotransferase system (PTS) for sugar accumulation. In this study, the gene *cbe0751* encoding the sugar-specific domains of a phosphotransferase belonging to the glucose family was cloned int...περισσότερα »
Development of patient decision support tools for motor neuron disease using stakeholder consultation: a study protocol
Introduction Motor neuron disease (MND) is a terminal, progressive, multisystem disorder. Well-timed decisions are key to effective symptom management. To date, there are few published decision support tools, also known as decision aids, to guide patients in making ongoing choices for symptom management and quality of life. This protocol is to develop and validate decision support tools for patients and families to use in conjunction with health professionals in MND multidisciplinary care. The tools will inform patients and families of the benefits and risks of each option, as wel...περισσότερα »
Searching for the mechanisms of change: a protocol for a realist review of batterer treatment programmes
Introduction Conflicting results reported by evaluations of typical batterer intervention programmes leave many judicial officials and policymakers uncertain about the best way to respond to domestic violence, and whether to recommend and fund these programmes. Traditional evaluations and systematic reviews tend to focus predominantly on whether the programmes 'worked' (eg, reduced recidivism) often at the exclusion of understanding for whom they may or may not have worked, under what circumstances, and why. Methods and analysis We are undertaking a realist review of the batterer...περισσότερα »
Gliding motility driven by individual cell-surface movements in a multicellular filamentous bacterium Chloroflexus aggregans
*Chloroflexus aggregans* is an unbranched multicellular filamentous bacterium having the ability of gliding motility. The filament moves straightforward at a constant rate, ~3 μm sec–1 on solid surface and occasionally reverses the moving direction. In this study, we successfully detected movements of glass beads on the cell-surface along long axis of the filament indicating that the cell-surface movement was the direct force for gliding. Microscopic analyses found that the cell-surface movements were confined to a cell of the filament, and each cell independently moved and revers... περισσότερα »
ATF3 provides protection from Staphylococcus aureus and Listeria monocytogenes infections
Activating transcription factor 3 (ATF3) is a stress-induced transcriptional regulator in eukaryote. The role of ATF3 in cancer has been well defined, but how ATF3 functions in bacterial infection is not well understood. Pneumococcal infection has been shown to induce ATF3 expression, which subsequently enhances cytokine production and provides protection from lethal *Streptococcus pneumoniae* infection, but the role of ATF3 in other Gram-positive (G+) infections remains unclear. Here, we report that infection with other G+ bacteria (*Staphylococcus aureus* and *Listeria monocytog... περισσότερα »
Impact of continuous Medical Aid utilisation on healthcare utilisation: unique insight using the 2008-2012 Korean Welfare Panel Study (KOWEPS)
Objectives Although there has been considerable discussion about the social safety net, few studies related to effect of duration of continuous receipt of Medical Aid on healthcare utilisation have been conducted. Therefore, we investigate whether the duration of receiving Medical Aid affected medical care utilisation. Setting Data were collected from the Korean Welfare Panel Study conducted from 2008 to 2012. Participants We included 11 783 samples. Interventions Estimating changes in their healthcare utilisation during specific time intervals (1, 2 and ≥3 years) after they ... περισσότερα »
Epidemiology of pertussis-related paediatric intensive care unit (ICU) admissions in Australia, 1997-2013: an observational study
Objective To review the epidemiology of pertussis-related intensive care unit (ICU) admissions across Australia, over a 17-year period. Design Retrospective descriptive study. Setting Australian ICUs contributing data to the Australian and New Zealand Paediatric Intensive Care (ANZPIC) Registry. The number of contributing ICUs increased over the study period, from 8 specialist paediatric ICUs in 1997 to 8 specialist paediatric and 13 general ICUs in 2013. Participants All paediatric (<16 years) ICU admissions, coded as pertussis-related, between 1 January 1997 and 31 December ... περισσότερα »
Navigational Bronchoscopy
for Early Lung Cancer: A Road to Therapy: AbstractPeripheral lung nodules remain challenging for accurate localization and diagnosis. Once identified, there are many strategies for diagnosis with heterogeneous risk benefit analysis. Traditional strategies such as conventional bronchoscopy have poor performance in locating and acquiring the required tissue. Similarly, while computerized-assisted transthoracic needle biopsy is currently the favored diagnostic procedure, it is associated with complications such as pneumothorax and hemorrhage. Video-assisted thoracoscopic and open sur...περισσότερα »
Tiotropium Respimat ® Versus HandiHaler ® : Bronchodilator Efficacy
Tiotropium Respimat ® Versus HandiHaler ® : Comparison of Bronchodilator Efficacy of Various Doses in Clinical Trials: Abstract IntroductionThe long-acting muscarinic antagonist tiotropium bromide is approved in many countries as maintenance therapy for chronic obstructive pulmonary disease (COPD). Tiotropium is available as a dry-powder formulation delivered via HandiHaler® (18 μg once daily) and is now also approved as an aqueous solution delivered via the Respimat® Soft Mist™ Inhaler (5 μg once daily, 2 puffs of 2.5 µg). Several studies have compared the efficacy of tiotropium ...περισσότερα »
Gadobutrol is a gadolinium-based contrast agent
Safety of gadobutrol in more than 1,000 pediatric patients: subanalysis of the GARDIAN study, a global multicenter prospective non-interventional study: Abstract BackgroundGadobutrol is a gadolinium-based contrast agent, uniquely formulated at 1.0 mmol/ml. Although there is extensive safety evidence on the use of gadobutrol in adults, few studies have addressed the safety and tolerability of gadobutrol in pediatric patients. ObjectiveThis subanalysis of data from the GARDIAN study evaluated the safety and use of gadobutrol in pediatric patients (age <18 years). Materials an...περισσότερα »
Nasopharyngeal carcinoma patients following radiotherapy : Impact of X-linked inhibitor of apoptosis protein on survival
Impact of X-linked inhibitor of apoptosis protein on survival of nasopharyngeal carcinoma patients following radiotherapy: AbstractThis study aims to investigate CNE1 and CNE2 cell proliferation and apoptosis of nasopharyngeal cancer (NPC) and X-linked inhibitor of apoptosis protein (XIAP) expression in NPC patients after radiotherapy. Quantitative real-time quantitative polymerase chain reaction (qRT-PCR) and Western Blot detected XIAP and XIAP-associated factor1 (XAF1) messenger RNA (mRNA) and protein expression of CNE1 and CNE2 in NPC cells irradiated by γ-ray; MTT and flow cyto...περισσότερα »
Gastrointestinal perforation during neoadjuvant chemotherapy with cisplatin and 5-fluorouracil in patients with esophageal cancer
: a report of two cases: AbstractNeoadjuvant chemotherapy (NAC) followed by surgery is the standard treatment for esophageal squamous cell carcinoma diagnosed as clinical stage II/III in Japan, and the indications for chemotherapy for esophageal cancer are increasing. Here, we report two patients who suffered from upper gastrointestinal perforation during NAC for esophageal cancer. NAC with cisplatin and 5-fluorouracil (CF regimen) was performed for both patients. Emergency operations were performed in all the patients prior to curative surgery for esophageal cancer. Endoscopic exa... περισσότερα »
"J Spec Oper Med"[jour]; +24 new citations
24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *"J Spec Oper Med"[jour]* These pubmed results were generated on 2016/04/06 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/209k155 via IFTTT
The Detmold Knife and the Empty Sleeve.
*The Detmold Knife and the Empty Sleeve.* Mil Med. 2016 Apr;181(4):395-396 Authors: Bradford C PMID: 27046188 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/22dPdiQ via IFTTT
Pilonidal Sinus Disease: A 10-Year Review Reveals Occupational Risk Factors and the Superiority of the Minimal Surgery Trephine Technique.
*Pilonidal Sinus Disease: A 10-Year Review Reveals Occupational Risk Factors and the Superiority of the Minimal Surgery Trephine Technique.* Mil Med. 2016 Apr;181(4):389-394 Authors: Levinson T, Sela T, Chencinski S, Derazne E, Tzur D, Elad H, Kreiss Y Abstract OBJECTIVES: To identify military occupational risk factors for pilonidal sinus disease (PSD) and to compare an Army Clinic minimal surgery with techniques used at public hospitals. METHODS: Review of a historical cohort of soldiers (3,407 with PSD) to determine PSD risk factors in military personnel and comparison of posto...περισσότερα »
Comparative Resuscitative Methods for Venlafaxine Toxicity in a Swine Model.
*Comparative Resuscitative Methods for Venlafaxine Toxicity in a Swine Model.* Mil Med. 2016 Apr;181(4):383-388 Authors: Fulton LV, Aitken J, Avery J, Kahl B, Negron A, Chavez B, Iosett N, Johnson D, O'Sullivan J Abstract OBJECTIVES: Venlafaxine overdose can lead to cardiovascular collapse that is difficult to resuscitate with traditional Advanced Cardiovascular Life Support protocols. Evidence has suggested that lipid emulsion infusion therapy has been successful in the treatment of antidepressant overdose. No studies have determined the optimal combination of lipid/advanced ca...περισσότερα »
"Let Me Get You a Nicotine Patch": Nurses' Perceptions of Implementing Smoking Cessation Guidelines for Hospitalized Veterans.
*"Let Me Get You a Nicotine Patch": Nurses' Perceptions of Implementing Smoking Cessation Guidelines for Hospitalized Veterans.* Mil Med. 2016 Apr;181(4):373-382 Authors: Katz DA, Stewart K, Paez M, Holman J, Adams SL, Vander Weg MW, Battaglia CT, Joseph AM, Titler MG, Ono S Abstract Many hospitalized smokers do not receive guideline-recommended tobacco treatment, but little is known about the perceptions of inpatient nurses with regard to tobacco treatment. We used a sequential explanatory mixed methods design to help explain the findings of an academic detailing intervention tr... περισσότερα »
Prevalence of Cardiac Arrhythmia Under Stress Conditions in Occupational Health Assessments of Young Military Servicemen and Servicewomen.
*Prevalence of Cardiac Arrhythmia Under Stress Conditions in Occupational Health Assessments of Young Military Servicemen and Servicewomen.* Mil Med. 2016 Apr;181(4):369-372 Authors: Sammito S, Gundlach N, Böckelmann I Abstract OBJECTIVES: In health assessments of young temporary-career volunteers who are up for re-enlistment, cardiac stress tests are mandatory to detect cardiac diseases and to confirm physical fitness. So far, there is no information available regarding the extent to which this time-consuming examination contributes to the diagnosis of pathological cardiac arrhyt... περισσότερα »
Intra-Weekly Variations of Influenza-Like Illness in Military Populations.
*Intra-Weekly Variations of Influenza-Like Illness in Military Populations.* Mil Med. 2016 Apr;181(4):364-368 Authors: Riley P, Cost AA, Riley S Abstract In this report, we describe and analyze a periodic pattern in influenza-like illness within active military populations, derived from the Defense Medical Surveillance System data set. We find that there is a well-defined pattern with peak incidence on Monday, decaying to Friday, and remaining roughly constant over the weekend. Moreover, we find that the pattern systematically changes in response to public holidays. We quantitati... περισσότερα »
Patients Provide Recommendations for Improving Patient Satisfaction.
*Patients Provide Recommendations for Improving Patient Satisfaction.* Mil Med. 2016 Apr;181(4):356-363 Authors: Moore AD, Hamilton JB, Krusel JL, Moore LG, Pierre-Louis BJ Abstract National Committee for Quality Assurance recommends patient-centered medical homes incorporate input from patient populations; however, many health care organizations do not. This qualitative study used two open-ended questions from 148 active duty Army Soldiers and their family members to illicit recommendations for primary care providers and clinic leadership that would improve their health care expe... περισσότερα »
Online Reporting of Military Sexual Trauma.
*Online Reporting of Military Sexual Trauma.* Mil Med. 2016 Apr;181(4):350-355 Authors: Burgess AW, Lee WJ, Carretta CM Abstract Case finding and treatment of military sexual trauma (MST) remains a serious problem in military and veteran populations as well as in the civilian population. This report provides descriptive examples, with statistics, of persons serving in the military or while living/working on a military base when they experienced unwanted sex. Males, more than females, never disclosed MST before online survey, had more physical injuries as a result and reported chr... περισσότερα »
Self-Directed Violence Aboard U.S. Navy Aircraft Carriers: An Examination of General and Shipboard-Specific Risk and Protective Factors.
*Self-Directed Violence Aboard U.S. Navy Aircraft Carriers: An Examination of General and Shipboard-Specific Risk and Protective Factors.* Mil Med. 2016 Apr;181(4):343-349 Authors: Saitzyk A, Vorm E Abstract Self-directed violence (SDV), which includes suicidal ideation with and without intent, suicidal preparatory behaviors and attempts with and without harm, non-suicidal self-directed violence, and completed suicide, has been a rising concern in the military. Military shipboard personnel may represent a unique subset of this population due to the distinct nature of deployment s... περισσότερα »
Predictors of Positive Illicit Drug Tests After OEF/OIF Deployment Among Army Enlisted Service Members.
*Predictors of Positive Illicit Drug Tests After OEF/OIF Deployment Among Army Enlisted Service Members.* Mil Med. 2016 Apr;181(4):334-342 Authors: Larson MJ, Mohr BA, Jeffery DD, Adams RS, Williams TV Abstract OBJECTIVE: To identify characteristics associated with testing positive for illicit drugs postdeployment among Army enlisted members. METHODS: Army active duty and National Guard/Reserve enlisted members returning from Operation Enduring Freedom/Operation Iraqi Freedom deployments in fiscal years 2008 to 2011, who submitted urine specimens for random and other illicit drug ...περισσότερα »
Lived Experience of the Warrior Nurse as an Advisor.
*Lived Experience of the Warrior Nurse as an Advisor.* Mil Med. 2016 Apr;181(4):328-333 Authors: Tow JC, Hudson DB Abstract PURPOSE: Described the lived experience of U.S. warrior nurses who served as advisors to host nation officials in Afghanistan. METHOD: The phenomenological approach was applied to obtain comprehensive descriptions from 10 warrior nurses. The modified Stevick-Colaizzi-Keen data analysis method was utilized as the researcher had performed in the role of interest. DISCUSSION: Textural themes included (a) challenging role, (b) challenging place, and (c) changed. ...περισσότερα »
Effect of Multiple Deployments on Military Families: A Cross-Sectional Study of Health and Well-Being of Partners and Children.
*Effect of Multiple Deployments on Military Families: A Cross-Sectional Study of Health and Well-Being of Partners and Children.* Mil Med. 2016 Apr;181(4):319-327 Authors: McGuire AC, Kanesarajah J, Runge CE, Ireland R, Waller M, Dobson AJ Abstract This study explored the impact of multiple deployments on the health and well-being of the partners (married or de facto) and children of Australian military personnel who have deployed frequently. Permission to contact military partners was sought from a sample of Australian Defence Force (ADF) members. Partners provided data on deploy... περισσότερα »
Preventing Exertional Death in Military Trainees: Recommendations and Treatment Algorithms From a Multidisciplinary Working Group.
*Preventing Exertional Death in Military Trainees: Recommendations and Treatment Algorithms From a Multidisciplinary Working Group.* Mil Med. 2016 Apr;181(4):311-318 Authors: Webber BJ, Casa DJ, Beutler AI, Nye NS, Trueblood WE, O'Connor FG Abstract Despite aggressive prevention programs and strategies, nontraumatic exertional sudden death events in military training continue to prove a difficult challenge for the Department of Defense. In November 2014, the 559th Medical Group at Joint Base San Antonio-Lackland, Texas, hosted a working group on sudden exertional death in military...περισσότερα »
Findings From the Department of Veterans Affairs Qarmat Ali Medical Surveillance Program.
*Findings From the Department of Veterans Affairs Qarmat Ali Medical Surveillance Program.* Mil Med. 2016 Apr;181(4):307-310 Authors: Ciminera P, Superior MJ, Bullman T Abstract OBJECTIVE: To review the Veterans Affairs (VA) medical surveillance program for Veterans with potential hexavalent chromium (CrVI) exposure that occurred during 2003. METHODS: Retrospective review of medical records of the 124 Veterans that participated in standardized, in-person clinical evaluations for possible CrVI exposure during the incident in question. The evaluations were reviewed to define popula...περισσότερα »
Economic Burden of Hearing Loss for the U.S. Military: A Proposed Framework for Estimation.
*Economic Burden of Hearing Loss for the U.S. Military: A Proposed Framework for Estimation.* Mil Med. 2016 Apr;181(4):301-306 Authors: Alamgir H, Tucker DL, Kim SY, Betancourt JA, Turner CA, Gorrell NS, Wong NJ, Sagiraju HK, Cooper SP, Douphrate DI, Whitworth KW, Marko D, Gimeno D, Cornell J, Hammill TL, Senchak AJ, Packer MD Abstract The goal of this multiphased research is to develop methods to comprehensively determine the economic impact of hearing impairment and noise-induced hearing injury among active duty U.S. Service Members. Several steps were undertaken to develop a f... περισσότερα »
Two-Year-Old Boy With Painless Hematuria.
*Two-Year-Old Boy With Painless Hematuria.* Mil Med. 2016 Apr;181(4):299-300 Authors: Gaulk NP, Light DE PMID: 27046173 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/22dPbYk via IFTTT
Platelet refractoriness
Management of the Platelet Refractory Patient via ScienceDirect Publication: Hematology/Oncology Clinics of North America Publication date: Available online 5 April 2016 *Source:*Hematology/Oncology Clinics of North America Author(s): Stefanie K. Forest, Eldad A. Hod TeaserPlatelet refractoriness occurs when there is an inadequate response to platelet transfusions, which typically has nonimmune causes, but is also associated with alloantibodies to human leukocyte antigens (HLAs) and/or human platelet antigens. Immune-mediated platelet refractoriness is suggested when a 10-minute to 1-... περισσότερα »
Cognitive functioning in meningioma patients
: a systematic review: AbstractThis systematic review evaluates relevant findings and methodologic aspects of studies on cognitive functioning in meningioma patients prior to and/or following surgery with or without adjuvant radiotherapy. PubMed and Web of Science electronic databases were searched until December 2015. From 1012 initially identified articles, 11 met the inclusion criteria for this review. Multiple methodological limitations were identified which include the lack of pre-treatment assessments, variations in the number and types of neuropsychological tests used, the n... περισσότερα »
The fat–fascia paddle only with a composite fibula flap: marked reduction in donor site morbidity
Fibula free flaps are used widely in head and neck reconstruction, primarily for their versatility and contribution to aesthetic and functional outcomes. The literature suggests that early complications such as wound dehiscence and skin graft loss can occur in up to a third of patients. The healing of these donor sites can be prolonged, and in certain cases may require an operative intervention. A method to overcome this problem is described herein. In raising the skin paddle, a standard lateral approach to the fibula harvest is used. from #ΓναθοΧειρουργική via xlomafota13 on Inor... περισσότερα »
Quality assessment of systematic reviews on alveolar socket preservation
The aim of this overview was to evaluate and compare the quality of systematic reviews, with or without meta-analysis, that have evaluated studies on techniques or biomaterials used for the preservation of alveolar sockets post tooth extraction in humans. An electronic search was conducted without date restrictions using the Medline/PubMed, Cochrane Library, and Web of Science databases up to April 2015. Eligibility criteria included systematic reviews, with or without meta-analysis, focused on the preservation of post-extraction alveolar sockets in humans. from #ΓναθοΧειρουργική ... περισσότερα »
The management of patients with anaplastic cell thyroid carcinoma
Spanish consensus for Anaplastic thyroid cancer (ATC) is the most aggressive solid tumor and almost uniformly lethal in humans. The Boards of the Thyroid Cancer Group of the Spanish Society of Endocrinology and Nutrition and the Grupo Español de Enfermedades Huérfanas e Infrecuentes of the Spanish Society of Oncology requested that an independent task force draft a more comprehensive consensus statement regarding ATC. All relevant literature was reviewed, including serial PubMed searches together with additional articles. This is the first, comprehensive Spanish consensus stateme...περισσότερα »
Personalized targeted therapy in relapsed/refractory childhood cancers
Abstract A41: TRICEPS: A feasibility study of In Canada, about 1500 pediatric cancers are diagnosed each year. Despite improvements in risk-stratified treatments, around 20% of childhood cancer patients do not respond to current therapies and ultimately succumb to their disease, urging the need for new and more effective therapeutic approaches. Personalized targeted therapy (PTT) based on next generation sequencing (NGS) may be a key component to increase cure rates and decrease treatment-related morbidity and mortality. To assess the feasibility of performing PTT clinical trials... περισσότερα »
Atypical Teratoid/ Rhabdoid Tumor (ATRT) is an aggressive cancer that accounts for up to 20% of infant brain tumors
Abstract B39: NQO1 as a therapeutic target for atypical teratoid/ rhabdoid tumor: Atypical Teratoid/ Rhabdoid Tumor (ATRT) is an aggressive cancer that accounts for up to 20% of infant brain tumors. Even with intense chemotherapy and radiation, approximately 75% of children die from their disease at a median of 10 months after diagnosis. We found that the pathognomonic genetic lesion of ATRTs and related malignant rhabdoid tumors (MRTs), loss of the SWI/SNF chromatin remodeling complex member INI1/hSNF5/SMARCB1, is associated with high expression of NAD(P)H:quinone oxidoreductase 1 ... περισσότερα »
An alveolar soft part sarcoma model
Abstract A11: An alveolar soft part sarcoma model to explore the mechanisms of tumorigenesis and metastasis: Alveolar soft part sarcoma (ASPS) is a highly malignant soft tissue tumor affecting predominantly children and adolescents in their buttocks or lower extremities. ASPS is characterized by its distinct histological features and t(X;17) translocation generating the ASPL-TFE3 gene fusion. However, the exact mechanisms of tumorigenesis and metastasis of ASPS remain largely unknown.A genetically engineered ASPS mouse model that showed histopothological and transriptome features sim...περισσότερα »
Everolimus (mTOR inhibitor) in combination with Vandetanib (multikinase inhibitor of EGFR,VEGFR,RET)
Abstract A48: Phase I study of Everolimus (mTOR inhibitor) in combination with Vandetanib (multikinase inhibitor of EGFR,VEGFR,RET) in children, adolescents, and young adults with advanced solid tumors: Background: Early phase clinical trials are often limited to adults, reducing the opportunity to explore safety and efficacy of new agents in children. Pre-clinical models have shown that combining an mTOR inhibitor (everolimus) with a multikinase VEGFR2 inhibitor (vandetanib) overcomes intrinsic and /or acquired resistance to either agent alone. Since this combination may h...περισσότερα »
Enhanced antitumor efficacy by combining oncolytic herpes simplex virus and Aurora A kinase inhibition
in models of neuroblastoma and malignant peripheral nerve sheath tumor: We previously reported xenograft models of neuroblastoma and malignant peripheral nerve sheath tumor (MPNST) are responsive to direct intratumoral injection of oncolytic Herpes Simplex Viruses (Parikh et al., Ped Blood Can 44:469, 2005; Mahller et al., Ped Blood Can 46:745, 2006; Mahller et al., Can Res 68:1170, 2008). We have confirmed these findings using an oncolytic HSV, Seprehvir (HSV1716), which is in clinical trials that include pediatric patients (NCT00931931, NCT02031965). The models showed wide vari...περισσότερα »
Development of a Spontaneously Active Dorsal Root Ganglia Assay using Multi-well Multielectrode Arrays
In vitro phenotypic assays of sensory neuron activity are important tools for identifying potential analgesic compounds. These assays are typically characterized by hyperexcitable and/or abnormally spontaneously active cells. While manual electrophysiology experiments provide high-resolution biophysical data to characterize both in vitro models and potential therapeutic modalities (e.g., action potential characteristics, the role of specific ion channels and receptors), these techniques are hampered by their low throughput. We have established a spontaneously active dorsal root ga...περισσότερα »
Associative spike-timing dependent potentiation of the basal dendritic excitatory synapses in the hippocampus in vivo
Spike timing dependent plasticity in the hippocampus has rarely been studied in vivo. Using extracellular potential and current source density analysis in urethane-anesthetized adult rats, we studied synaptic plasticity at the basal-dendritic excitatory synapse in CA1 after excitation-spike (ES) pairing; E was a weak basal-dendritic excitation evoked by stratum oriens stimulation, and S was a population spike evoked by stratum radiatum apical-dendritic excitation. We hypothesize that positive ES pairing - generating synaptic excitation before a spike - results in long-term potenti... περισσότερα »
Strategies for targeting primate neural circuits with viral vectors
Understanding how the brain works requires understanding how different types of neurons contribute to circuit function and behavior. Progress on this front has been accelerated by the new tools of optogenetics and chemogenetics, which provide an unprecedented level of control over distinct neuronal types in small animals. In primates, however, targeting specific types of neurons with these tools remains challenging. In this review, we discuss existing and emerging strategies for directing genetic manipulations to targeted neurons in the adult primate central nervous system. We rev... περισσότερα »
Implicit Learning and Generalization of Stretch Response Modulation in Humans
Adaptation of neural responses to repeated muscle stretching likely represents implicit learning to minimize muscle resistance to perturbations. To test this hypothesis, the forearm was placed on a horizontal manipulandum. Elbow flexors or extensors compensated an external load and were stretched by 20° or 70° rotations. Participants were instructed not to intervene by intentionally modifying the muscle resistance elicited by stretching. In addition to phasic stretch reflexes (SRs), muscle stretching was associated with inhibitory periods (IPs) in thjavascript:void(0)e ongoing mus... περισσότερα »
The involvement of model-based but not model-free learning signals during observational reward learning in the absence of choice
A major open question is whether computational strategies thought to be used during experiential learning, specifically model-based and model-free reinforcement-learning, also support observational learning. Furthermore, the question of how observational learning occurs when observers must learn about the value of options from observing outcomes in the absence of choice, has not been addressed. In the present study we used a multi-armed bandit task that encouraged human participants to employ both experiential and observational learning while they underwent functional magnetic res...περισσότερα »
Fast Adapting Mechanoreceptors are Important for Force Control in Precision Grip but not for Sensorimotor Memory
Sensory feedback from cutaneous mechanoreceptors in the fingertips is important in effective object manipulation, allowing appropriate scaling of grip and load forces during precision grip. However the role of mechanoreceptor subtypes in these tasks remains incompletely understood. To address this issue, psychophysical tasks which may specifically assess function of type I rapidly adapting (RAI) and slowly adapting (SAI) mechanoreceptors were used with object manipulation experiments to examine the regulation of grip force control in an experimental model of graded reduction in ta...περισσότερα »
Novel method for functional brain imaging in awake minimally restrained rats
Functional magnetic resonance imaging (fMRI) in rodents holds great promise for advancing our knowledge about human brain function. However, the use of anesthetics to immobilize rodents during fMRI experiments has restricted the type of questions that can be addressed using this technique. Here we describe an innovative procedure to confine rodents in order to carry out fMRI without the need of anesthetics (including initial anesthesia). We show that with 8-10 days of acclimation rats can be conscious and remain still during fMRI experiments under minimal stress. In addition, we pr... περισσότερα »
High-resolution and cell-type-specific photostimulation mapping shows weak excitatory versus strong inhibitory inputs in the bed nucleus of the stria terminalis
The bed nucleus of the stria terminalis (BNST) is a key component of the extended amygdala, and has been implicated in anxiety and addiction. As individual neurons function within neural circuits, it is important to understand local microcircuits and larger network connections of identified neuronal types, and understand how maladaptive changes in the BNST neural networks are induced by stress and drug use. However, due to limitations of classic anatomical and physiological methods, local circuit organization of synaptic input to specific BNST neuron types is not well understood. I... περισσότερα »
Microstimulation of the Lumbar DRG Recruits Primary Afferent Neurons in Localized Regions of Lower Limb
Patterned microstimulation of the dorsal root ganglion (DRG) has been proposed as a method for delivering tactile and proprioceptive feedback to amputees. Previous studies demonstrated that large and medium diameter afferent neurons could be recruited separately, even several months after implantation. However, those studies did not examine the anatomical localization of sensory fibers recruited by microstimulation in the DRG. Achieving precise recruitment with respect to both modality and receptive field locations will likely be crucial to create a viable sensory neuroprosthesis.... περισσότερα »
Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brainstem neurons
Many rapidly firing neurons, including those in the Medial Nucleus of the Trapezoid Body (MNTB) in the auditory brainstem, express "high threshold" voltage-gated Kv3.1 potassium channels that activate only at positive potentials and are required for stimuli to generate rapid trains of actions potentials. We now describe the actions of two imidazolidinedione derivatives, AUT1 and AUT2, which modulate Kv3.1 channels. Using CHO cells stably expressing rat Kv3.1 channels, we found that lower concentrations of these compounds shift the voltage of activation of Kv3.1 currents towards ne... περισσότερα »
Standard EEG in diagnostic process of prolonged disorders of consciousness
After a comatose state, severely brain-injured patients might remain in a vegetative state (VS; Multi-Society Task Force on PVS, 1994), and eventually evolve in a minimally conscious state (MCS; Giacino et al., 2002). On the basis of the complexity of patients’ behaviours, a sub categorization of MCS patients into “MCS minus” (MCS-) and “MCS plus” (MCS+) has been recently proposed (Bruno et al., 2011). The distinction among the above diagnostic groups can be very difficult, because of fluctuations of clinical conditions and presence of severe sensori-motor deficits (Majerus et al., ... περισσότερα »
Lower motor neurons – counting cogs in the ALS machine
Lower motor neuron (LMN) degeneration is at the core of amyotrophic lateral sclerosis (ALS), producing much of the disability through the disease course and ultimately death from denervation of the respiratory muscles. The LMN and the muscle it innervates are uniquely accessible parts of the nervous system such that they are readily amenable to functional and structural interrogation. For this reason, there have been extensive neurophysiological and pathological studies of the diseased LMN in ALS. from Physiology via xlomafota13 on Inoreader http://ift.tt/1S3Xbvu
Join us Tuesday, May 3, 2016, for Speech-Language Awareness & Information Day!
*FREE ADMISSION!* This community event raises awareness about the resources available to individuals with various speech & language impairments, their family members and friends, and other allied professionals in the San Diego area. *Click below for details and to rsvp!* [image: SAID banner] from Hearing and Balance via ola Kala on Inoreader http://ift.tt/1VaCe2n via IFTTT
Injection of the viroimmunotherapeutic oncolytic herpes virus rRp450 increases survival
Abstract B13: Injection of the viroimmunotherapeutic oncolytic herpes virus rRp450 increases survival of orthotopic mouse models of Group 3 medulloblastoma and atypical teratoid/rhabdoid tumors: Background: Both Group 3 medulloblastomas and atypical teratoid/ rhabdoid tumors (AT/RTs) are highly aggressive pediatric brain tumors which have a tendency to metastasize early and are known for their poor outcomes. Current standards of care using chemotherapy and irradiation are associated with significant morbidities, giving impetus for the development of new treatments. Oncolytic virothe...περισσότερα »
Oncolytic herpes virotherapy
Abstract A14: Checkpoinblockade enhances oncolytic herpes virotherapy in immunosuppressive sarcoma models: Most solid tumors are characterized by an immunosuppressive microenvironment, limiting the effectiveness of antitumor immunotherapeutics. Programmed cell death protein (PD)-1-mediated T cell suppression via engagement of its ligand, PD-L1, is of particular interest due to recent successes in selected adult cancers. The utility of PD1-directed therapy for pediatric cancers is unknown, especially given the paucity of mutations and thus infrequent neoantigens in many types of chil... περισσότερα »
Evaluation of MRI protocols for the assessment of lumbar facet joints after MR-guided focused ultrasound treatment
MR-guided focused ultrasound (MRgFUS) might be a very safe and effective minimally invasive technique to treat facet joint pain caused by arthritis and other degenerative changes. However, there are still safe... from Pharmacology via ola Kala on Inoreader http://ift.tt/23dAIlc via IFTTT
Diffuse intrinsic pontine gliomas
Abstract IA26: Oncogenic mechanisms in Diffuse intrinsic pontine glioma (DIPG) is a devastating disease with no effective cures. DIPG arises in the brainstem and is found almost exclusively in children. Mutations in canonical cancer signalling pathways including the RTK/RAS/PI3K pathway, the Tp53 pathway, and the CDK4/6 G1 checkpoint occur in DIPGs, targeting different effectors within these pathways and resulting in significant genetic heterogeneity between tumors. However, genome-wide studies provided abundant evidence that unique selective pressures drive HGG in children compa...περισσότερα »
Bevacizumab Prevents Brain Metastases
Bevacizumab Prevents Brain Metastases: Patients with nonsquamous non–small cell lung cancer (nsNSCLC; largely lung adenocarcinoma) are at high risk of developing brain metastases. Preclinical data suggested that anti–VEGF-A therapy may prevent the formation of nsNSCLC brain metastases. Whether non-brain metastases are also prevented, and whether bevacizumab shows a brain metastases–preventive activity in cancer patients is unknown. Data of one nsNSCLC (stage IIIB/IV, AVAiL) and two breast cancer bevacizumab trials (HER2 negative, AVADO; HER2 positive, AVEREL) were retrospectively a... περισσότερα »
CDK Inhibition Sensitizes p53-Mutated Cells to Doxorubicin
CDK Inhibition Sensitizes p53-Mutated Cells to Doxorubicin: Triple-negative breast cancer (TNBC) is an aggressive malignancy in which the tumors lack expression of estrogen receptor, progesterone receptor, and HER2. Hence, TNBC patients cannot benefit from clinically available targeted therapies and rely on chemotherapy and surgery for treatment. While initially responding to chemotherapy, TNBC patients are at increased risk of developing distant metastasis and have decreased overall survival compared with non-TNBC patients. A majority of TNBC tumors carry p53 mutations, enabling t...περισσότερα »
Oncolytic Adenovirus and L-carnosine
Synergistic Activity of Oncolytic viruses are able to specifically replicate, infect, and kill only cancer cells. Their combination with chemotherapeutic drugs has shown promising results due to the synergistic action of virus and drugs; the combinatorial therapy is considered a potential clinically relevant approach for cancer. In this study, we optimized a strategy to absorb peptides on the viral capsid, based on electrostatic interaction, and used this strategy to deliver an active antitumor drug. We used L-carnosine, a naturally occurring histidine dipeptide with a significan... περισσότερα »
Introducing the doughnut inspired compression dressing for penile shaft reconstruction
We describe an innovative technique in applying a graft fixation dressing when reconstructing the penile shaft. from #ENT via xlomafota13 on Inoreader http://ift.tt/23jFESa via IFTTT
Beard Reconstruction - a Surgical Algorithm
Facial defects with loss of hair-bearing regions can be caused by trauma, infection, tumor excision, or burn injury. The presented analysis evaluates a series of different surgical approaches with a focus on male beard reconstruction, emphasizing the role of tissue expansion of regional and free flaps. from #ENT via xlomafota13 on Inoreader http://ift.tt/1VyYge7 via IFTTT
Targeted Radiotherapies through Femtomedicine
Discovery of There is a compelling need to develop anticancer therapies that target cancer cells and tissues. Arising from innovative femtomedicine studies, a new class of non–platinum-based halogenated molecules (called FMD molecules) that selectively kill cancer cells and protect normal cells in treatments of multiple cancers has been discovered. This article reports the first observation of the radiosensitizing effects of such compounds in combination with ionizing radiation for targeted radiotherapy of a variety of cancers. We present *in vitro* and *in vivo* studies focused ... περισσότερα »
Bone marrow transplantation for monoallelic signal transducer and activator of transcription 1 deficiency
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Signal transducer and activator of transcription (STAT) 1 plays an important role in the response of immune and nonimmune cells to stimulations. Complete absence of STAT1 results in susceptibility to mycobacteria, viral, and fungal infections. Monoallelic mutations in STAT1 were identified among patients with diverse immune abnormalities such as chronic mucocutaneous candidiasis, autoimmunity, bowel inflammation, […]
Calcineurin inhibitors impair neutrophil activity against Aspergillus fumigatus in allogenic hematopoietic stem cell transplant recipients
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
In allogenic hematopoietic stem cell transplant recipients, fungal innate immunity driven by neutrophils is altered during the first months of the graft, in relation with the use of calcineurin inhibitors. from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PVx1DN via IFTTT
Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Bronchiolitis is the leading cause of infant hospitalization in the United States,1 and cohort studies suggest that up to 50% of these hospitalized infants will develop childhood asthma.1 The 2 most common viral etiologies of severe bronchiolitis (ie, bronchiolitis requiring hospitalization) are respiratory syncytial virus (RSV) and rhinovirus (RV).1 Although these 2 viruses have been […]
Immunological defects in severe mucocutaneous HSV-2 infections: response to IFNγ therapy
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Immune defects in dsRNA recognition and IFNγ production underlie susceptibility to severe reactivations with HSV-2. Treatment with recombinant IFNγ shows clinical efficacy, and it should be considered in patients with severe recurrent HSV-2 infections. from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1qujApV via IFTTT
Assessment of corticosteroid response in pediatric patients with severe asthma by using a multidomain approach
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
There is no agreed upon definition of systemic corticosteroid response in asthmatic children. Moreover, pediatric severe therapy-resistant asthma (STRA) is heterogeneous, and thus response to steroids is unlikely to be uniform in all patients. from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PVx2rg via IFTTT
Serum periostin is associated with type 2 immunity in severe asthma
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Periostin is an extracellular matrix protein that is upregulated by type 2 cytokines IL-4 and IL-13 in bronchial epithelial cells and lung fibroblasts, is deposited widely in the airway of subjects with asthma, and is one of the most differentially expressed bronchial epithelial genes between patients with asthma and healthy control subjects.1 Periostin is particularly […]
Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
This study suggests QGE031 as an alternative anti-IgE treatment to omalizumab because it has potential for greater efficacy against allergic responses in the airways and skin. from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1quiKJV via IFTTT
Introducing the doughnut inspired compression dressing for penile shaft reconstruction
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
We describe an innovative technique in applying a graft fixation dressing when reconstructing the penile shaft. from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/23jFESa via IFTTT
Beard Reconstruction – a Surgical Algorithm
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Facial defects with loss of hair-bearing regions can be caused by trauma, infection, tumor excision, or burn injury. The presented analysis evaluates a series of different surgical approaches with a focus on male beard reconstruction, emphasizing the role of tissue expansion of regional and free flaps. from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VyYge7 via […]
Cholesterol Homeostasis in Cancer
Cholesterol Homeostasis in Cancer: The roles played by cholesterol in cancer development and the potential of therapeutically targeting cholesterol homeostasis is a controversial area in the cancer community. Several epidemiologic studies report an association between cancer and serum cholesterol levels or statin use, while others suggest that there is not one. Furthermore, the Cancer Genome Atlas (TCGA) project using next-generation sequencing has profiled the mutational status and expression levels of all the genes in diverse cancers, including those involved in cholesterol metabo...περισσότερα »
Image intensive soft tissue sarcoma surveillance
uncovers pathology earlier than patient complaints but with frequent initially indeterminate lesions: Introduction Post-treatment surveillance follow-up soft-tissue sarcomas is controversial. Protocols are highly variable. This study retrospectively evaluates an image intense protocol to assess benefits of identifying true pathology compared to incidental findings. Methods A retrospective chart review was conducted on a single orthopedic oncologist's soft tissue sarcoma patients under a consistent protocol (TAD). Study population included patients who underwent resection of non-met...περισσότερα »
Glutamine in Alleviation of Radiation-Induced Severe Oral Mucositis
: A Meta-Analysis.: Nutr Cancer. 2016 Apr 4;:1-9 Authors: Leung HW, Chan AL Abstract The aim of this meta-analysis was to assess the effectiveness of glutamine to treat severe mucositis induced by radiation therapy in patients with head and neck cancer. We undertook electronic searches of PubMed (1990 to January 2015), Embase (1990 to January 2015), and the Cochrane Library (2013, Issue 2) to identify relevant studies. We included randomized controlled trials of glutamine to alleviate oral mucositis (OM) in patients with head and neck cancer who received radiotherapy. Information ... περισσότερα »
Zerumbone, a Sesquiterpene, Controls Proliferation and Induces Cell Cycle Arrest in Human Laryngeal Carcinoma Cell Line Hep-2.
Zerumbone, a Sesquiterpene, Controls Proliferation and Induces Cell Cycle Arrest in Human Laryngeal Carcinoma Cell Line Hep-2.: Nutr Cancer. 2016 Apr 4;:1-8 Authors: Jegannathan SD, Arul S, Dayalan H Abstract Zerumbone (ZER), a sesquiterpene found in Zingiber zerumbet Smith, has been shown to possess antiproliferative, anticancer, antioxidant, and anti-inflammatory activity against various types of human carcinoma. The molecular mechanism by which ZER mediates its activity against many cancer types is revealed by many studies. Upregulation of proapoptotic molecules and suppression...περισσότερα »
Joint motion quality in chondromalacia progression assessed by vibroacoustic signal analysis
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Due to the specific biomechanical environment of the patellofemoral joint, chondral disorders, including chondromalacia, are often observed in this articulation. Chondromalacia via pathological changes in cartilage may lead to qualitative impairment of knee joint motion. from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1Se9b7I via IFTTT
Pulmonary rehabilitation in lung cancer
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Lung cancer remains a challenging disease with high morbidity and mortality despite targeted therapy. Symptom burden related to cancer impairs quality of life and functional status in lung cancer patients and survivors. Pulmonary rehabilitation has been recognized as an effective, non-invasive intervention for patients with chronic respiratory disease. It is well established that pulmonary rehabilitation benefits chronic obstruction pulmonary disease (COPD) patients through improved exercise capacity and symptoms. from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1Mgqk4... περισσότερα »
The Effect of Distractive Function on Volitional Preemptive Abdominal Contraction During a Loaded Forward Reach in Normal Subjects
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Volitional preemptive abdominal contraction (VPAC) is used to protect the spine and preventing injury. No published studies to data have examined the effect of distraction on VPAC use during function. from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1RFzFmH via IFTTT
Performance Variability as a Predictor of Response to Aphasia Treatment
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
*Background.* Performance variability in individuals with aphasia is typically regarded as a nuisance factor complicating assessment and treatment. *Objective.* We present the alternative hypothesis that intraindividual variability represents a fundamental characteristic of an individual's functioning and an important biomarker for therapeutic selection and prognosis. *Methods.* A total of 19 individuals with chronic aphasia participated in a 6-week trial of imitation-based speech therapy. We assessed improvement both on overall language functioning and repetition ability. Further... περισσότερα »
Effects of a High-Fat or High-Sucrose Diet on Ultraviolet B Irradiation-Induced Carcinogenesis and Tumor Growth
in Melanin-Possessing Hairless Mice.: Nutr Cancer. 2016 Apr 4;:1-13 Authors: Sumiyoshi M, Kimura Y Abstract We herein compared the effects of the chronic feeding of high-fat (HF), high-sucrose (HS), and low-fat/low-sucrose (control) diets on carcinogenesis following chronic ultraviolet B (UVB) irradiation in hairless mice. UVB irradiation-induced carcinogenesis was more prominent in HF diet-fed group than in control diet- and HS diet-fed groups. The HS diet group, as well as the HF diet one, showed tumor development and growth, increased skin matrix metalloproteinase (MMP) and bl... περισσότερα »
Introducing the doughnut inspired compression dressing for penile shaft reconstruction
We describe an innovative technique in applying a graft fixation dressing when reconstructing the penile shaft. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/23jFESa via IFTTT
Beard Reconstruction - a Surgical Algorithm
Facial defects with loss of hair-bearing regions can be caused by trauma, infection, tumor excision, or burn injury. The presented analysis evaluates a series of different surgical approaches with a focus on male beard reconstruction, emphasizing the role of tissue expansion of regional and free flaps. from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1VyYge7 via IFTTT
Muscle, functional and cognitive adaptations after flywheel resistance training in stroke patients: a pilot randomized controlled trial
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Resistance exercise (RE) improves neuromuscular function and physical performance after stroke. Yet, the effects of RE emphasizing eccentric (ECC; lengthening) actions on muscle hypertrophy and cognitive funct... from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1TD9cr1 via IFTTT
Overexpression of two stress-responsive, small, non-coding RNAs, 6S and tmRNA, imparts butanol tolerance in Clostridium acetobutylicum
While extensively studied in several model organisms, the role of small, non-coding RNAs in the stress response remains largely unexplored in *Clostridium* organisms. About 100 years after the first industrial Acetone–Butanol–Ethanol fermentation process, based on the Weizmann *Clostridium acetobutylicum* strain, strain tolerance to butanol remains a crucial factor limiting the economics of the process. Several studies have examined the response of this organism to metabolite stress, and several genes have been engaged to impart enhanced tolerance, but no sRNAs have yet been direc...περισσότερα »
De novo biosynthesis of resveratrol by site-specific integration of heterologous genes in Escherichia coli
Resveratrol is a well-known triphenolic natural product present in red wine. For its contribution to human health, the demand for resveratrol as a food and nutrition supplement has increased significantly. In recent years, the rapid development of synthetic biology has promoted extensive work to increase the production of resveratrol in microbes. However, supplementation of expensive phenylpropanoic precursors was required in current engineered strains. Here, we first utilized the site-specific integration strategy to produce resveratrol in *Escherichia coli*. The genes *tal*, *4c... περισσότερα »
The Histone Variant H3.3 Is Enriched at Drosophila Amplicon Origins but Does not Mark Them for Activation
Eukaryotic DNA replication begins from multiple origins. The origin recognition complex (ORC) binds origin DNA and scaffolds assembly of a pre-Replicative Complex (pre-RC), which is subsequently activated to initiate DNA replication. In multicellular eukaryotes, origins do not share a strict DNA consensus sequence and their activity changes in concert with chromatin status during development, but mechanisms are ill-defined. Previous genome-wide analyses in *Drosophila* and other organisms have revealed a correlation between ORC binding sites and the histone variant H3.3. This corr...περισσότερα »
Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response
The TTT complex is composed of the three essential proteins Tel2, Tti1 and Tti2. The complex is required to maintain the steady state levels of the phosphatidylinositol 3-kinase-related kinase (PIKK) proteins including mTOR, ATM/Tel1, ATR/Mec1, and TRRAP/Tra1, all of which serve as regulators of critical cell signaling pathways. Due to their association with heat shock proteins, and with newly synthesized PIKK peptides, components of the TTT complex may act as co-chaperones. Here, we analyze the consequences of depleting the cellular level of Tti2 in *Saccharomyces cerevisiae*. We ... περισσότερα »
Genomic Signatures of Experimental Adaptation to Antimicrobial Peptides in Staphylococcus aureus
The evolution of resistance against antimicrobial peptides has long been considered unlikely due to their mechanism of action, yet experimental selection with AMPs results in rapid evolution of resistance in several species of bacteria. Although numerous studies have utilized mutant screens to identify loci that determine AMP susceptibility, there is a dearth of data concerning the genomic changes which accompany experimental evolution of AMP resistance. Using genome re-sequencing we analysed the mutations which arise during experimental evolution of resistance to the cationic AMP...περισσότερα »
Insulin-like growth factors and their potential role in cardiac epigenetics
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Abstract Cardiovascular disease (CVD) constitutes a major public health threat worldwide, accounting for 17.3 million deaths annually. Heart disease and stroke account for the majority of healthcare costs in the developed world. While much has been accomplished in understanding the pathophysiology, molecular biology and genetics underlying the diagnosis and treatment of CVD, we know less about the role of epigenetics and their molecular determinants. The impact of environmental changes and epigenetics in CVD is now emerging as critically important in understanding the origin of dis... περισσότερα »
miR-19b controls cardiac fibroblast proliferation and migration
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Abstract Cardiac fibrosis is a fundamental constituent of a variety of cardiac dysfunction, making it a leading cause of death worldwide. However, no effective treatment for cardiac fibrosis is available. Therefore, novel therapeutics for cardiac fibrosis are highly needed. Recently, miR-19b has been found to be able to protect hydrogen peroxide (H2O2)-induced apoptosis and improve cell survival in H9C2 cardiomyocytes, while down-regulation of miR-19b had opposite effects, indicating that increasing miR-19b may be a new therapeutic strategy for attenuating cellular apoptosis during... περισσότερα »
Editorial Board/Reviewing Committee
from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1q86cXX via IFTTT
The fat–fascia paddle only with a composite fibula flap: marked reduction in donor site morbidity
Fibula free flaps are used widely in head and neck reconstruction, primarily for their versatility and contribution to aesthetic and functional outcomes. The literature suggests that early complications such as wound dehiscence and skin graft loss can occur in up to a third of patients. The healing of these donor sites can be prolonged, and in certain cases may require an operative intervention. A method to overcome this problem is described herein. In raising the skin paddle, a standard lateral approach to the fibula harvest is used. from #ΓναθοΧειρουργική via xlomafota13 on Inorea... περισσότερα »
Quality assessment of systematic reviews on alveolar socket preservation
The aim of this overview was to evaluate and compare the quality of systematic reviews, with or without meta-analysis, that have evaluated studies on techniques or biomaterials used for the preservation of alveolar sockets post tooth extraction in humans. An electronic search was conducted without date restrictions using the Medline/PubMed, Cochrane Library, and Web of Science databases up to April 2015. Eligibility criteria included systematic reviews, with or without meta-analysis, focused on the preservation of post-extraction alveolar sockets in humans. from #ΓναθοΧειρουργική vi... περισσότερα »
Treatment of head and neck cancers with spot-scanning proton therapy
Clinically-applicable Monte Carlo-based biological dose optimization for the treatment of head and neck cancers with spot-scanning proton therapy via International Journal of Radiation Oncology*Biology*Physics Publication date: Available online 6 April 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics Author(s): Hok Seum Wan Chan Tseung, Jiasen Ma, Cole R. Kreofsky, Daniel J. Ma, Chris Beltran PurposeTo demonstrate the feasibility of fast Monte Carlo (MC) based inverse biological planning for the treatment of head and neck tumors in spot-scanning proton therapy.... περισσότερα »
CD123 immunostaining patterns in systemic mastocytosis
: differential expression in disease subgroups and potential prognostic value: *CD123 immunostaining patterns in systemic mastocytosis: differential expression in disease subgroups and potential prognostic value* Leukemia 30, 914 (April 2016). doi:10.1038/leu.2015.348 Authors: A Pardanani, K K Reichard, D Zblewski, R A Abdelrahman, E A Wassie, W G Morice II, C Brooks, K L Grogg, C A Hanson, A Tefferi & D Chen A Pardanani, K K Reichard, D Zblewski, R A Abdelrahman, E A Wassie, W G Morice II, C Brooks, K L Grogg, C A Hanson, A Tefferi and D Chen Abstract CD123 is the α-s... περισσότερα »
Correlation of Beta-2 Adrenergic Receptor Expression in Tumor-Free Surgical Margin and at the Invasive Front of Oral Squamous Cell Carcinoma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα
Conclusions. The correlation of β2-AR expression in OSCC and tumor-free surgical margins suggests a role of this receptor in tumor progression and its expression in normal oral epithelium seems to be constitutive. PMID: 27042179 [PubMed] (Source: Journal of Oncology) from squamous cell carcinoma via ok on Inoreader http://ift.tt/1VyVWny via IFTTT
Interferon-alpha for the therapy of myeloproliferative neoplasms: targeting the malignant clone
Interferon-alpha for the therapy of myeloproliferative neoplasms: targeting the malignant clone: *Interferon-alpha for the therapy of myeloproliferative neoplasms: targeting the malignant clone* Leukemia 30, 776 (April 2016). doi:10.1038/leu.2015.326 Authors: J-J Kiladjian, S Giraudier & B Cassinat J-J Kiladjian, S Giraudier and B Cassinat Abstract Interferon alpha (IFN-α) has been used for over 30 years to treat myeloproliferative neoplasms (MPNs). IFN-α was shown to induce clinical, hematological, molecular and histopathological responses in small clinical studies. ...περισσότερα »
Lymphoid and histiocytic malignancies
Independent development of lymphoid and histiocytic malignancies from a shared early precursor: *Independent development of lymphoid and histiocytic malignancies from a shared early precursor* Leukemia 30, 955 (April 2016). doi:10.1038/leu.2015.193 Authors: E Waanders, K M Hebeda, E J Kamping, P J T A Groenen, A Simons, A Hoischen, M C J Jongmans, P M Hoogerbrugge, F N van Leeuwen, R P Kuiper & D M W M te Loo E Waanders, K M Hebeda, E J Kamping, P J T A Groenen, A Simons, A Hoischen, M C J Jongmans, P M Hoogerbrugge, F N van Leeuwen, R P Kuiper and D M W M te Loo Abstrac... περισσότερα »
Standard EEG in diagnostic process of prolonged disorders of consciousness
After a comatose state, severely brain-injured patients might remain in a vegetative state (VS; Multi-Society Task Force on PVS, 1994), and eventually evolve in a minimally conscious state (MCS; Giacino et al., 2002). On the basis of the complexity of patients’ behaviours, a sub categorization of MCS patients into “MCS minus” (MCS-) and “MCS plus”… Continue reading Standard EEG in diagnostic process of prolonged disorders of consciousness
Stevens-Johnson Syndrome
Treatment Modalities and Clinical Outcomes in Ocular Sequelae of Stevens-Johnson Syndrome Over 25 Years–A Paradigm Shift.: Authors: Iyer G, Srinivasan B, Agarwal S, Pillai VS, Ahuja A Abstract PURPOSE: To highlight and compare the outcomes of management for the ocular sequelae of Stevens-Johnson syndrome (SJS) over 25 years in a tertiary eye care institute. METHODS:… Continue reading Stevens-Johnson Syndrome
Stevens-Johnson Syndrome Versus Chemical Burn.
Infectious Keratitis in Limbal Stem Cell Deficiency Cornea. 2016 ;35(1):51-5 Authors: Kang BS, Kim MK, Wee WR, Oh JY Abstract PURPOSE: To investigate the incidence, clinical and microbiological characteristics, risk factors, and therapeutic outcome of infectious keratitis in patients with limbal stem cell deficiency (LSCD) related to Stevens-Johnson syndrome (SJS) and corneal chemical burn. METHODS:… Continue reading Stevens-Johnson Syndrome Versus Chemical Burn.
Glutamine in Alleviation of Radiation-Induced Severe Oral Mucositis
A Meta-Analysis.: Nutr Cancer. 2016 Apr 4;:1-9 Authors: Leung HW, Chan AL Abstract The aim of this meta-analysis was to assess the effectiveness of glutamine to treat severe mucositis induced by radiation therapy in patients with head and neck cancer. We undertook electronic searches of PubMed (1990 to January 2015), Embase (1990 to January 2015),… Continue reading Glutamine in Alleviation of Radiation-Induced Severe Oral Mucositis
The Effect of Upper Airway Surgery on Continuous Positive Airway Pressure Levels and Adherence: A Systematic Review and Meta-Analysis
The Effect of Upper Airway Surgery on Continuous Positive Airway Pressure Levels and Adherence: A Systematic Review and Meta-Analysis: Background /Aims: The aim of this study was to determine the effect of upper airway surgery (UAS) on continuous positive airway pressure (CPAP). A secondary objective was to determine if a decrease in CPAP from UAS… Continue reading The Effect of Upper Airway Surgery on Continuous Positive Airway Pressure Levels and Adherence: A Systematic Review and Meta-Analysis
Sentinel Lymphnode in Patients With Papillary Thyroid Carcinoma and in Patients With Suspected Thyroid Neoplasia
Sentinel Lymphnode in Patients With Papillary Thyroid Carcinoma and in Patients With Suspected Thyroid Neoplasia: Conditions: Thyroid Neoplasms; Thyroid Cancer Intervention: Procedure: Histological investigation of the SN Sponsor: Region Skane The standard surgical treatment for highly differentiated papillary thyroid cancer > 10 mm according to recent national and international guidelines, is total thyroidectomy and central… Continue reading Sentinel Lymphnode in Patients With Papillary Thyroid Carcinoma and in Patients With Suspected Thyroid Neoplasia
Characterization and in vitro activity of a branched peptide boronic acid that interacts with HIV-1 RRE RNA
Publication date: Available online 5 April 2016 Source:Bioorganic & Medicinal Chemistry Author(s): Jessica E. Wynn, Wenyu Zhang, Denis M. Tebit, Laurie R. Gray, Marie-Louise Hammarskjold, David Rekosh, Webster L. Santos A branched peptide containing multiple boronic acids was found to bind RRE IIB selectively and inhibit HIV-1 p24 capsid production in a dose-dependent manner. Structure-activity… Continue reading Characterization and in vitro activity of a branched peptide boronic acid that interacts with HIV-1 RRE RNA
CryoBalloon Ablation System in Patients Undergoing Esophagectomy
Clinical Study to Evaluate CryoBalloon Ablation System in Patients Undergoing Esophagectomy: Condition: Esophageal Cancer Intervention: Device: CryoBalloon Ablation System Sponsor: C2 Therapeutics, Inc. Arms Assigned Interventions Single Arm To evaluate safety and treatment effect of the CryoBalloon Ablation System for the Ablation of human esophageal epithelium in patient scheduled to undergo esophagectomy Device: CryoBalloon Ablation… Continue reading CryoBalloon Ablation System in Patients Undergoing Esophagectomy
Medical Radiation Protectants (FORRAD®) and Trolamine (Biafine) for the Management of Radiation Dermat itis in Patients With Nasopharyngeal Carcinoma Receiving IMRT
Comparison of Efficacy and Safety Between Medical Radiation Protectants (FORRAD®) and Trolamine (Biafine) for the Management of Radiation Dermatitis in Patients With Nasopharyngeal Carcinoma Receiving IMRT: Conditions: Nasopharyngeal Neoplasms; Radiodermatitis Interventions: Drug: Medical Radiation Protectants (FORRAD®); Drug: Trolamine (Biafine) Sponsor: Yun-fei Xia Radiation therapy remains the principal treatment for nasopharyngeal carcinoma (NPC). Although intensity modulated… Continue reading Medical Radiation Protectants (FORRAD®) and Trolamine (Biafine) for the Management of ...περισσότερα »
Elective neck management for squamous cell carcinoma metastatic to the parotid area lymph nodes
Elective neck management for squamous cell carcinoma metastatic to the parotid area lymph nodes: Abstract The objective of this study is to determine if radiotherapy (RT) alone to the cervical lymphatics is a suitable alternative to elective neck dissection (END) in patients who undergo parotidectomy and postoperative RT for squamous cell carcinoma metastatic to the… Continue reading Elective neck management for squamous cell carcinoma metastatic to the parotid area lymph nodes
Prediction of the invasion depth of superficial squamous cell carcinoma based on microvessel morphology: magnifying endoscopic classification of the Japan Esophageal Society
Prediction of the invasion depth of superficial squamous cell carcinoma based on microvessel morphology: magnifying endoscopic classification of the Japan Esophageal Society: AbstractPredicting invasion depth of superficial esophageal squamous cell carcinoma is crucial in determining the precise indication for endoscopic resection because the rate of lymph node metastasis increases in proportion to the invasion depth of the carcinoma. Previous studies have shown a close relationship between microvascular patterns observed by Narrow Band Imaging magnifying endoscopy and invasion dep...περισσότερα »
Novel method for functional brain imaging in awake minimally restrained rats
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 38 δευτερόλεπτα
Functional magnetic resonance imaging (fMRI) in rodents holds great promise for advancing our knowledge about human brain function. However, the use of anesthetics to immobilize rodents during fMRI experiments has restricted the type of questions that can be addressed using this technique. Here we describe an innovative procedure to confine rodents in order to carry out fMRI without the need of anesthetics (including initial anesthesia). We show that with 8-10 days of acclimation rats can be conscious and remain still during fMRI experiments under minimal stress. In addition, we pr... περισσότερα »
High-resolution and cell-type-specific photostimulation mapping shows weak excitatory versus strong inhibitory inputs in the bed nucleus of the stria terminalis
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 38 δευτερόλεπτα
The bed nucleus of the stria terminalis (BNST) is a key component of the extended amygdala, and has been implicated in anxiety and addiction. As individual neurons function within neural circuits, it is important to understand local microcircuits and larger network connections of identified neuronal types, and understand how maladaptive changes in the BNST neural networks are induced by stress and drug use. However, due to limitations of classic anatomical and physiological methods, local circuit organization of synaptic input to specific BNST neuron types is not well understood. I... περισσότερα »
Microstimulation of the Lumbar DRG Recruits Primary Afferent Neurons in Localized Regions of Lower Limb
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 38 δευτερόλεπτα
Patterned microstimulation of the dorsal root ganglion (DRG) has been proposed as a method for delivering tactile and proprioceptive feedback to amputees. Previous studies demonstrated that large and medium diameter afferent neurons could be recruited separately, even several months after implantation. However, those studies did not examine the anatomical localization of sensory fibers recruited by microstimulation in the DRG. Achieving precise recruitment with respect to both modality and receptive field locations will likely be crucial to create a viable sensory neuroprosthesis.... περισσότερα »
Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brainstem neurons
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 38 δευτερόλεπτα
Many rapidly firing neurons, including those in the Medial Nucleus of the Trapezoid Body (MNTB) in the auditory brainstem, express "high threshold" voltage-gated Kv3.1 potassium channels that activate only at positive potentials and are required for stimuli to generate rapid trains of actions potentials. We now describe the actions of two imidazolidinedione derivatives, AUT1 and AUT2, which modulate Kv3.1 channels. Using CHO cells stably expressing rat Kv3.1 channels, we found that lower concentrations of these compounds shift the voltage of activation of Kv3.1 currents towards ne... περισσότερα »
Pain Reduction and Repeat Injections after Transforaminal Epidural Injection with Particulate versus Non-particulate Steroid for the Treatment of Chronic Painful Lumbosacral Radiculopathy
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 38 δευτερόλεπτα
Corticosteroid choice for lumbar transforaminal epidural injection (TFESI) remains controversial. Whether to utilize particulate or non-particulate steroid preparations for these injections remains an unanswered question in the literature. from Rehabilitation via xlomafota13 on Inoreader http://ift.tt/1MgqkS2 via IFTTT
Joint motion quality in chondromalacia progression assessed by vibroacoustic signal analysis
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 38 δευτερόλεπτα
Due to the specific biomechanical environment of the patellofemoral joint, chondral disorders, including chondromalacia, are often observed in this articulation. Chondromalacia via pathological changes in cartilage may lead to qualitative impairment of knee joint motion. from Rehabilitation via xlomafota13 on Inoreader http://ift.tt/1Se9b7I via IFTTT
Pulmonary rehabilitation in lung cancer
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 38 δευτερόλεπτα
Lung cancer remains a challenging disease with high morbidity and mortality despite targeted therapy. Symptom burden related to cancer impairs quality of life and functional status in lung cancer patients and survivors. Pulmonary rehabilitation has been recognized as an effective, non-invasive intervention for patients with chronic respiratory disease. It is well established that pulmonary rehabilitation benefits chronic obstruction pulmonary disease (COPD) patients through improved exercise capacity and symptoms. from Rehabilitation via xlomafota13 on Inoreader http://ift.tt/1Mgq... περισσότερα »
The morphology and clinical significance of the intraforaminal ligaments at the l5-s1 level
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 38 δευτερόλεπτα
[image: spinee56992-fig-0001.sml] The extraforaminal ligaments between the L5-S1 lumbar spinal nerves and the tissues surrounding the intervertebral foramina have been well studied. However, little research has been undertaken to describe the local anatomy of the intraforaminal portion of the L5-S1 spine; detailed anatomic studies of the intraforaminal ligaments of the L5-S1 have not been performed. from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/23jluYv via IFTTT
The Effect of Distractive Function on Volitional Preemptive Abdominal Contraction During a Loaded Forward Reach in Normal Subjects
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 38 δευτερόλεπτα
Volitional preemptive abdominal contraction (VPAC) is used to protect the spine and preventing injury. No published studies to data have examined the effect of distraction on VPAC use during function. from Rehabilitation via xlomafota13 on Inoreader http://ift.tt/1RFzFmH via IFTTT
The Histone Variant H3.3 Is Enriched at Drosophila Amplicon Origins but Does not Mark Them for Activation
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 39 δευτερόλεπτα
Eukaryotic DNA replication begins from multiple origins. The origin recognition complex (ORC) binds origin DNA and scaffolds assembly of a pre-Replicative Complex (pre-RC), which is subsequently activated to initiate DNA replication. In multicellular eukaryotes, origins do not share a strict DNA consensus sequence and their activity changes in concert with chromatin status during development, but mechanisms are ill-defined. Previous genome-wide analyses in *Drosophila* and other organisms have revealed a correlation between ORC binding sites and the histone variant H3.3. This corr...περισσότερα »
Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 39 δευτερόλεπτα
The TTT complex is composed of the three essential proteins Tel2, Tti1 and Tti2. The complex is required to maintain the steady state levels of the phosphatidylinositol 3-kinase-related kinase (PIKK) proteins including mTOR, ATM/Tel1, ATR/Mec1, and TRRAP/Tra1, all of which serve as regulators of critical cell signaling pathways. Due to their association with heat shock proteins, and with newly synthesized PIKK peptides, components of the TTT complex may act as co-chaperones. Here, we analyze the consequences of depleting the cellular level of Tti2 in *Saccharomyces cerevisiae*. We ... περισσότερα »
Genomic Signatures of Experimental Adaptation to Antimicrobial Peptides in Staphylococcus aureus
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 39 δευτερόλεπτα
The evolution of resistance against antimicrobial peptides has long been considered unlikely due to their mechanism of action, yet experimental selection with AMPs results in rapid evolution of resistance in several species of bacteria. Although numerous studies have utilized mutant screens to identify loci that determine AMP susceptibility, there is a dearth of data concerning the genomic changes which accompany experimental evolution of AMP resistance. Using genome re-sequencing we analysed the mutations which arise during experimental evolution of resistance to the cationic AMP...περισσότερα »
Sorafenib metabolism, transport, and enterohepatic recycling: physiologically based modeling and simulation in mice
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 41 δευτερόλεπτα
Conclusions Translation of the mouse model to humans for the purpose of explaining exceptionally high human pharmacokinetic variability and its relationship with exposure-dependent dose-limiting toxicities will require delineation of the importance of these processes on disposition. (Source: Cancer Chemotherapy and Pharmacology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Se8OKl via IFTTT
Bone marrow transplantation for monoallelic signal transducer and activator of transcription 1 deficiency
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 41 δευτερόλεπτα
Signal transducer and activator of transcription (STAT) 1 plays an important role in the response of immune and nonimmune cells to stimulations. Complete absence of STAT1 results in susceptibility to mycobacteria, viral, and fungal infections. Monoallelic mutations in STAT1 were identified among patients with diverse immune abnormalities such as chronic mucocutaneous candidiasis, autoimmunity, bowel inflammation, […]
Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 41 δευτερόλεπτα
Bronchiolitis is the leading cause of infant hospitalization in the United States,1 and cohort studies suggest that up to 50% of these hospitalized infants will develop childhood asthma.1 The 2 most common viral etiologies of severe bronchiolitis (ie, bronchiolitis requiring hospitalization) are respiratory syncytial virus (RSV) and rhinovirus (RV).1 Although these 2 viruses have been […]
Calcineurin inhibitors impair neutrophil activity against Aspergillus fumigatus in allogenic hematopoietic stem cell transplant recipients
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 41 δευτερόλεπτα
In allogenic hematopoietic stem cell transplant recipients, fungal innate immunity driven by neutrophils is altered during the first months of the graft, in relation with the use of calcineurin inhibitors. (Source: Journal of Allergy and Clinical Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1We6jxM via IFTTT
Assessment of corticosteroid response in pediatric patients with severe asthma by using a multidomain approach
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 41 δευτερόλεπτα
There is no agreed upon definition of systemic corticosteroid response in asthmatic children. Moreover, pediatric severe therapy-resistant asthma (STRA) is heterogeneous, and thus response to steroids is unlikely to be uniform in all patients. (Source: Journal of Allergy and Clinical Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Se8PxU via IFTTT
Immunological defects in severe mucocutaneous HSV-2 infections: response to IFNγ therapy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 41 δευτερόλεπτα
Immune defects in dsRNA recognition and IFNγ production underlie susceptibility to severe reactivations with HSV-2. Treatment with recombinant IFNγ shows clinical efficacy, and it should be considered in patients with severe recurrent HSV-2 infections. (Source: Journal of Allergy and Clinical Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1We6lpi via IFTTT
Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 41 δευτερόλεπτα
This study suggests QGE031 as an alternative anti-IgE treatment to omalizumab because it has potential for greater efficacy against allergic responses in the airways and skin. (Source: Journal of Allergy and Clinical Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Se8NGf via IFTTT
Serum periostin is associated with type 2 immunity in severe asthma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 41 δευτερόλεπτα
Periostin is an extracellular matrix protein that is upregulated by type 2 cytokines IL-4 and IL-13 in bronchial epithelial cells and lung fibroblasts, is deposited widely in the airway of subjects with asthma, and is one of the most differentially expressed bronchial epithelial genes between patients with asthma and healthy control subjects.1 Periostin is particularly […]
Editorial Board/Reviewing Committee
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 41 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1q86cXX via IFTTT
The fat–fascia paddle only with a composite fibula flap: marked reduction in donor site morbidity
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 41 δευτερόλεπτα
Fibula free flaps are used widely in head and neck reconstruction, primarily for their versatility and contribution to aesthetic and functional outcomes. The literature suggests that early complications such as wound dehiscence and skin graft loss can occur in up to a third of patients. The healing of these donor sites can be prolonged, and […]
Massive Open Online Courses: what will be their legacy?
Massive Open Online Courses (MOOCs) dominated discussions of online learning and higher education in the news media and in universities between 2012 and 2015. However, fashions pass, needs change and technology evolves. This Commentary looks back, pauses on the present, and then looks forward. Whilst MOOCs are a significant milestone on the road that online teaching and learning is following, open, distance and online learning started long before MOOCs and will continue to grow in importance when MOOCs are just an interesting footnote in its development. from Infection via ola Ka...περισσότερα »
Distribution of human papillomaviruses and bacterial vaginosis
Distribution of human papillomaviruses and bacterial vaginosis in HIV positive women with abnormal cytology in Mombasa, Kenya: Abstract BackgroundHPV is the major etiological factor in the causal pathway for cervical cancer, which is the leading cancer among women in sub-Saharan Africa. HIV is associated with a higher prevalence and a broader range of high-risk HPV genotypes. Studies have shown a positive association between Bacterial vaginosis (BV) and HPV and HIV. Also, in African women, BV was found to be significantly associated with vaginal inflammation. The high prevalence o...περισσότερα »
Salivary Nickel Levels
Effects of Fixed Orthodontic Treatment Using Conventional, Copper-Included, and Epoxy-Coated Nickel-Titanium Archwires on Salivary Nickel Levels: A Double-Blind Randomized Clinical Trial: AbstractOrthodontic archwires, especially nickel-titanium (NiTi) ones, are a major source of nickel release. Despite their importance, no in vivo studies have assessed the ion release from conventional or new generations of NiTi archwires (copper-included and epoxy-coated). This double-blind parallel randomized clinical trial was done on 84 saliva specimens sampled at two time points from 42 ortho... περισσότερα »
Therapeutic cancer vaccines by mimicking viral infections
Designing therapeutic cancer vaccines by mimicking viral infections: AbstractThe design of efficacious and cost-effective therapeutic vaccines against cancer remains both a research priority and a challenge. For more than a decade, our laboratory has been involved in the development of synthetic peptide-based anti-cancer therapeutic vaccines. We first dedicated our efforts in the identification and validation of peptide epitopes for both CD8 and CD4 T cells from tumor-associated antigens (TAAs). Because of suboptimal immune responses and lack of therapeutic benefit of peptide vacci...περισσότερα »
CNS infections in patients with hematological disorders
CNS infections in patients with hematological disorders (including allogeneic stem cell transplantation) -Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO): Diagnosis of CNS infections remains a great challenge in patients with hematological disorders since symptoms might both be masked and be mimicked by other conditions such as metabolic disturbances or consequences from antineoplastic treatment. Thus, awareness of this complication is crucial and any suspicion of a CNS infection should lead to timely and a... περισσότερα »
Primary and recurrent leiomyosarcoma of the inferior vena cava
Role of surgery in the multimodal treatment of primary and recurrent leiomyosarcoma of the inferior vena cava: Background The optimal treatment of leiomyosarcoma (LMS) of the inferior vena cava (IVC) is still unclear, especially in the metastatic and/or recurrent setting. We herein evaluated the long-term outcome after aggressive management. Methods Eleven patients underwent surgery for primary LMS of the IVC between 2000 and 2012. The clinical, pathological, and survival data were reviewed. Results The IVC was managed by graft replacement in four cases, primary repair in four, and ... περισσότερα »
Denture Stomatitis
Evidence Regarding the Treatment of Denture Stomatitis: Abstract Denture stomatitis is a common inflammatory condition affecting the mucosa underlying complete dentures. It is associated with denture microbial biofilm, poor denture hygiene, poor denture quality, and nocturnal denture use. Numerous treatment methodologies have been used to treat stomatitis; however, a gold standard treatment has not been identified. The aim of this systematic review is to report on the current knowledge available in studies representing a range of evidence on the treatment of denture stomatitis.
Speech rate effects on the processing of conversational speech across the adult life spana)
Speech rate effects on the processing of conversational speech across the adult life spana): [image: cm_sbs_024_plain.png] This study investigates the effect of speech rate on spoken word recognition across the adult life span. Contrary to previous studies, conversational materials with a natural variation in speech rate were used rather than lab-recorded stimuli that are subsequently artificially time-compressed. It was investigated whether older adults' speech recognition is more adversely affected by increased speech rate compared to younger and middle-aged adults, and which in... περισσότερα »
Effects of age on speech and voice quality ratingsa)
Effects of age on speech and voice quality ratingsa): The quality of communication may be affected by listeners' perception of talkers' characteristics. This study examined if there were effects of talker and listener age on the perception of speech and voice qualities. Younger and older listeners judged younger and older talkers' gender and age, then rated speech samples on pleasantness, naturalness, clarity, ease of understanding, loudness, and the talker's suitability to be an audiobook reader. For the same talkers, listeners also rated voice samples on pleasantness, roughness, ... περισσότερα »
