The Foramen Ovale : Circularity,Solidity,Axes of a Best Fit Ellipse,Aspect Ratio,and Roundness
Circularity, Solidity, Axes of a Best Fit Ellipse, Aspect Ratio, and Roundness of the Foramen Ovale: A Morphometric Analysis With Neurosurgical Considerations.: The structure of the foramen ovale of the sphenoid bone is clinically important, particularly with regard to surgical procedures that cannulate the foramen such as percutaneous trigeminal rhizotomy for the treatment of trigeminal neuralgia, percutaneous biopsy of parasellar lesions, and electroencephalographic analysis of the temporal lobe among patients undergoing selective amygdalohippocampectomy. Differences in the morpho... περισσότερα »
Cervical Spine Injury in Pediatric Patients With Facial Fractures
Characteristics of Cervical Spine Injury in Pediatric Patients With Facial Fractures.: Overview: Cervical spine injury may present with pediatric patients having sustained fractures of the craniofacial skeleton. Management considerations of the cervical spine often take priority to the fractures of the facial skeleton. The goal of this study was to examine this subset of patients with a focus on initial presentation and need for intervention. Methods: A retrospective review from 2000 to 2012 of all facial fractures in patients
Treating the Golden Implant Visibility on a Paralytic Eye by Using the Capsule Shield Technique.
Treating the Golden Implant Visibility on a Paralytic Eye by Using the Capsule Shield Technique.: Static upper eyelid weight loading is a well known treatment option for patients who suffer from paralytic lagophtalmus. Golden implants may cause some complications such as extrusion, postoperative ptosis, visibility of the implant from the skin, infection, or dislocation. Our patients applied to our clinic with discomfort of the implant's easily noticeable visibility in their daily life. They were scheduled the operation programme for reducing visibility of implant. In operation, capsu... περισσότερα »
Double Trapezoid-Shaped Osteotomy for Reduction Malarplasty.
A New Double Trapezoid-Shaped Osteotomy for Reduction Malarplasty.: Background: Various surgical techniques have been introduced and developed for the reduction of wide zygomatic bone. However, the previous methods have several disadvantages, including the following: potential cheek droop, a limited amount of possible volume reduction, an unfavorable contour due to nonunion, and limited inward repositioning of the zygomatic arch. Thus, the authors introduce an effective method to overcome the limitations and disadvantages of other previous reduction malarplasty techniques. Methods: F...περισσότερα »
Inhibition of matrix metalloproteinases and toxicity of gold and platinum nanoparticles in L929 fibroblast cells
Inhibition of matrix metalloproteinases and toxicity of gold and platinum nanoparticles in L929 fibroblast cells: This study evaluated the inhibition of matrix metalloproteases (MMPs) and cellular responses elicited by gold (Au) and platinum (Pt) nanoparticles (NPs). The interaction of MMP-1 and NPs was evaluated using an MMP assay kit. The cultured L929 cells were exposed to various concentrations of NPs. The cellular responses to NPs were examined using a cytotoxicity assay (that evaluated cell viability and lactic dehydrogenase production), real-time polymerase chain reaction (R... περισσότερα »
Oral Propranolol With Topical Timolol Maleate Therapy for Mixed Infantile Hemangiomas in Oral and Maxillofacial Regions.
Oral Propranolol With Topical Timolol Maleate Therapy for Mixed Infantile Hemangiomas in Oral and Maxillofacial Regions.: Purpose: The combination treatment for mix infantile hemangiomas (IHs) using oral propranolol with topical timolol maleate was not well documented in the literature. The aim of this study was to evaluate the therapeutic effects and safety of oral propranolol along with topical timolol maleate or oral propranolol alone for treating mixed IHs in the oral and maxillofacial regions. Methods: Between March 2013 and June 2014, a total of 31 patients with mixed IHs in th... περισσότερα »
Face Transplantation
Face Transplantation from Crossing the Barriers to Restoration of Function
Nasal Surgery : Transverse Slicing of the Sixth-Seventh Costal Cartilaginous Junction: A Novel Technique to Prevent Warping
Transverse Slicing of the Sixth-Seventh Costal Cartilaginous Junction: A Novel Technique to Prevent Warping in Nasal Surgery.: Background: Costal cartilage is an important reconstructive tissue for correcting nasal deformities. Warping of costal cartilage, a recognized complication, can lead to significant functional and aesthetic problems. The authors present a technique to prevent warping that involves transverse slicing of the sixth-seventh costal cartilaginous junction, that when sliced perpendicular to the long axis of the rib, provides multiple long, narrow, clinically useful ... περισσότερα »
Understanding Cranioplasty.
Understanding Cranioplasty
Trauma Involving the Inner Maxillofacial Region
A Window View From the Orient on Trauma Involving the Inner Maxillofacial Region: From China to the Global Community With Love
Primary Infraorbital Foramen Decompression for the Zygomaticomaxillary Complex Fracture
Primary Infraorbital Foramen Decompression for the Zygomaticomaxillary Complex Fracture: Is It Essential?.: Purpose: The frequency of zygomaticomaxillary fracture is second only to nasal bone fracture. Up to 30% to 80% of zygomaticomaxillary fracture patients complain of sensory disturbance results from infraorbital nerve injury. The objective of this study was to detect what factors are related to infraorbital nerve recovery and specifically to investigate decompression of infraorbital foramen improves sensory recovery. Patients and Methods: A total of 257 patients were assessed wit... περισσότερα »
Narrowing Genioplasty Using Biodegradable Screws
A Simple and Reliable Method of Narrowing Genioplasty Using Biodegradable Screws.: The T-osteotomy technique is widely performed to improve lower face aesthetics. During this narrowing genioplasty procedure, metal fixtures are required to rigidly fix the bone segments. Specifically, the use of biodegradable osteofixations has become a viable surgical option as more patients now have the desire to surreptitiously undergo aesthetic surgery. The present report describes a narrowing genioplasty procedure with the use of biodegradable screws only. When the T-osteotomy technique was perfo...περισσότερα »
Osteoneogenesis due to periosteal elevation
Osteoneogenesis due to periosteal elevation with degradable and nondegradable devices in Göttingen Minipigs: Periosteal distraction or elevation has been known as an experimental method to induce new bone formation. Although it uses the principles of distraction osteogenesis no further osteotomy is necessary. The purpose of this study was to test degradable PDLLA (poly-DL-lactide), PGA (polyglygolic acid) and non degradable (titanium) devices in a calvarian model in Göttingen Minipigs and to evaluate the point of origin of the new bone formation. All degradable devices collapsed to ... περισσότερα »
A protocol to create Bisphosphonate-related osteonecrosis of the jaw in rat animal model
Introducing a protocol to create Bisphosphonate-related osteonecrosis of the jaw in rat animal model: Previously published animal investigations on bisphosphonate-related osteonecrosis of the jaws (BRONJ) showed a variety of methods for BRONJ induction and inconsistent findings. The aim of present study was to develop a reliable protocol for BRONJ induction in rat animal model.
Statins on oral and perioral microorganisms
Systematic review of the in vitro effects of statins on oral and perioral microorganisms: Statins are medications administered orally and are widely used for lowering the blood cholesterol level. The aim of this study was to investigate the effects of orally administered statins on microorganisms infecting oral and perioral tissues. We performed a systematic review of published studies of the in vitro antimicrobial effects of statins on bacteria, viruses, and fungi, and searched PubMed, Web of Science, Cochrane Central, and Google scholar. Studies show that most statins exhibit an... περισσότερα »
Cardiovascular complications of obstructive sleep apnea
Does experimental paradoxical sleep deprivation (EPSD) is an appropriate model for evaluation of cardiovascular complications of obstructive sleep apnea?: Abstract PurposeSome of the previous studies have used animal model of paradoxical sleep deprivation for investigation of sleep loss complications. The present study is designed to examine the effectiveness and reliability of this model for investigation and assessment of some cardiovascular complications of obstructive sleep apnea syndrome. MethodsThe Wistar rat groups were divided into the control group, the Test48 and Tes...περισσότερα »
Induced pluripotent stem cell-derived mesenchymal stem cells (iPSMSCs)-alginate-calcium phosphate paste for bone tissue engineering
A self-setting iPSMSC-alginate-calcium phosphate paste for bone tissue engineering via Dental Materials Publication date: Available online 29 December 2015 *Source:*Dental Materials Author(s): Ping Wang, Yang Song, Michael D. Weir, Jinyu Sun, Liang Zhao, Carl G. Simon, Hockin H.K. Xu ObjectivesCalcium phosphate cements (CPCs) are promising for dental and craniofacial repairs. The objectives of this study were to: (1) develop an injectable cell delivery system based on encapsulation of induced pluripotent stem cell-derived mesenchymal stem cells (iPSMSCs) in microbeads; (2) develop a n...περισσότερα »
Autologous bone grafts harvested from the iliac crest or intraoral jaw bone
Stability of simultaneously placed dental implants with autologous bone grafts harvested from the iliac crest or intraoral jaw bone: Abstract BackgroundJaw bone and iliac bone are the most frequently used autologous bone sources for dental implant placement in patients with atrophic alveolar ridges. However, the comparative long-term stability of these two autologous bone grafts have not yet been investigated. The aim of this study was to compare the stability of simultaneously placed dental implants with autologous bone grafts harvested from either the iliac crest or the intraora... περισσότερα »
Osteolysis of unknown origin
Osteolysis of unknown origin: a case report: Abstract BackgroundSarcoidosis is a granulomatous disease that may affect any organ of the body. The most frequent loci of manifestation are the lungs. However, there are individual cases where bones are affected. The literature describes cases in which swelling or fistula were the first findings of a bone lesion. This is the first case reporting an osteolysis in both angles of the mandibles which led to the diagnosis of sarcoidosis with multi-organ involvement. Case presentationThe authors present a 74 years old European female pati... περισσότερα »
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Oral health screening of athletes with intellectual disability
Treatment needs and impact of oral health screening of athletes with intellectual disability in Belgium: Abstract BackgroundSpecial Olympics Special Smiles (SOSS) is an initiative created for oral health data collection and education in oral hygiene for athletes with an intellectual disability. The aims of this study were to evaluate treatment needs of participants of Special Olympics in Belgium 2013 in comparison with those from 2008 and to assess the impact of screening and referral within the SOSS in a group of athletes who participated in two consecutive events, 2012 and 2013....περισσότερα »
Osteoporosis (OP) : Pulsed wave low-level laser therapy on the biomechanical properties of the vertebral body
An evaluation of the effect of pulsed wave low-level laser therapy on the biomechanical properties of the vertebral body in two experimental osteoporosis rat models: AbstractOsteoporosis (OP) increases vertebral fragility as a result of the biomechanical effects of diminished bone structure and composition. This study has aimed to assess the effects of pulsed wave low-level laser therapy (PW LLLT) on cancellous bone strength of an ovariectomized (OVX-d) experimental rat model and a glucocorticoid-induced OP (GIOP) experimental rat model. There were four OVX-d groups and four dexame...περισσότερα »
Photodynamic inactivation of antibiotic-resistant bacteria and biofilms by hematoporphyrin monomethyl ether
Photodynamic inactivation of antibiotic-resistant bacteria and biofilms by hematoporphyrin monomethyl ether: AbstractThe worldwide increase in bacterial antibiotic resistance has led to a search for alternative antibacterial therapies. A promising approach to killing antibiotic-resistant bacteria is photodynamic antimicrobial chemotherapy, which uses light in combination with a photosensitizer to induce a phototoxic reaction. We evaluated the photodynamic inactivation (PDI) efficiency of hematoporphyrin monomethyl ether (HMME) on antibiotic-resistant bacteria and biofilms. HMME exh... περισσότερα »
Deep Neuromuscular Relaxation in Patients for Thoraco-laparoscopic Esophagectomy
Deep Neuromuscular Relaxation in Patients for Thoraco-laparoscopic Esophagectomy: *Conditions*: Neuromuscular Block; Esophageal Cancer; Surgery *Intervention*: Drug: Rocuronium *Sponsors*: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); Merck Sharp & Dohme Corp. Rationale: Endoscopic (thoraco-laparoscopic) esophageal surgery is a high risk procedure where the use of deep neuromuscular block (NMB) may increase field visibility and anaesthesia conditions. Under these conditions, boluses of muscle relaxants can be given on indication only OR by contin... περισσότερα »
Individualized Elective Neck Irradiation Based on MRI in NPC Patients
Individualized Elective Neck Irradiation Based on MRI in NPC Patients: *Condition*: Nasopharyngeal Carcinoma *Interventions*: Radiation: Elective neck irradiation; Radiation: Whole neck irradiation *Sponsor*: Sun Yat-sen University Currently, most protocols of nasopharyngeal carcinoma(NPC) of various research bodies such as the Radiation Therapy Oncology Group require routine elective irradiation to the retropharyngeal area and to levels II-V, and also to the supraclavicular lymph nodal areas regardless of the status of nodal metastasis. Previous studies had confirmed tha...περισσότερα »
Pembrolizumab With Locally Delivered Radiation Therapy for the Initial Treatment of Metastatic Esophageal Cancers
Pembrolizumab With Locally Delivered Radiation Therapy for the Initial Treatment of Metastatic Esophageal Cancers: *Conditions*: Esophageal Neoplasms; Esophageal Cancer; Cancer of the Esophagus *Interventions*: Drug: Pembrolizumab; Radiation: Brachytherapy; Procedure: Endoscopic biopsy; Procedure: Ultrasound-guided biopsy; Procedure: Computed tomography-guided biopsy; Procedure: Peripheral blood collection *Sponsors*: Washington University School of Medicine; Merck Sharp & Dohme Corp. The investigators propose to treat patients with metastatic esophageal ca... περισσότερα »
Nasal angiosarcoma metastatic to the larynx
Nasal angiosarcoma metastatic to the larynx: Case report and systematic review of the literature: Abstract Background Laryngeal angiosarcoma is rare and the prognosis is poor. The purpose of this study was to describe the first case of cutaneous angiosarcoma metastatic to the larynx and systematically review all cases of laryngeal angiosarcoma. Methods A 61-year-old man presented with an alar lesion diagnosed as angiosarcoma and was treated with wide local resection and radiation. Six years later, he presented with a laryngeal mass histologically similar to the initial tumor. A sys... περισσότερα »
Recurrent giant mandibular ameloblastoma in young adults
Recurrent giant mandibular ameloblastoma in young adults: Abstract Background The purpose of the study was to define the most appropriate management of the giant mandibular ameloblastoma (GMA) in young adults. Methods A retrospective study was performed on patients with GMA <30 years old. The data collected included initial treatment, tumor margins, reconstruction, and follow-up. Patients evaluated speech, chewing, swallowing, and facial appearance after definitive treatment. Results Thirteen patients were identified with recurrent solid/multicystic disease requiring further treatmen...περισσότερα »
Merkel cell carcinoma
Merkel cell carcinoma: Do you know your guidelines?: Abstract Background Merkel cell carcinoma (MCC) is a cutaneous neuroendocrine malignancy that exhibits clinically aggressive features and is associated with a poor prognosis. The incidence of MCC seems to be increasing for reasons unknown, and is estimated to be 0.32/100,000 in the United States. Methods This article will review the current literature and National Comprehensive Cancer Network practice guidelines in the treatment of MCC. Results Resection of MCC with negative margins remains the mainstay of therapy. Positive nodal d...περισσότερα »
External-beam radiotherapy (EBRT) in differentiated thyroid cancer (DTC)
External-beam radiotherapy for differentiated thyroid cancer locoregional control: A statement of the American Head and Neck Society: Abstract The use of external-beam radiotherapy (EBRT) in differentiated thyroid cancer (DTC) is debated because of a lack of prospective clinical data, but recent retrospective studies have reported benefits in selected patients. The Endocrine Surgery Committee of the American Head and Neck Society provides 4 recommendations regarding EBRT for locoregional control in DTC, based on review of literature and expert opinion of the authors. (1) EBRT is re... περισσότερα »
EBRT for differentiated thyroid cancer locoregional control
External-beam radiotherapy for differentiated thyroid cancer locoregional control: A statement of the American Head and Neck Society: Abstract The use of external-beam radiotherapy (EBRT) in differentiated thyroid cancer (DTC) is debated because of a lack of prospective clinical data, but recent retrospective studies have reported benefits in selected patients. The Endocrine Surgery Committee of the American Head and Neck Society provides 4 recommendations regarding EBRT for locoregional control in DTC, based on review of literature and expert opinion of the authors. (1) EBRT is re... περισσότερα »
Wegener’s Granulomatosis with Otologic Symptoms and Unilateral Parotid Gland Enlargement
An Unusual Presentation of Wegener’s Granulomatosis with Otologic Symptoms and Unilateral Parotid Gland Enlargement: AbstractWegener’s granulomatosis is an autoimmune disease affecting the lungs, kidneys and upper respiratory organs. Major salivary gland enlargement is a rare presenting symptom. We are reporting a rare case of Wegener’s granulomatosis presenting with pain in right ear with moderate hearing loss and unilateral painless parotid gland enlargement.
Respiratory Distress in a Neonate
Respiratory Distress in a Neonate: A neonate had respiratory distress requiring endotracheal intubation, zygomatic hypoplasia, micrognathia, and bilateral grade III microtia with atresia of the external auditory canals, mild decrease in RV systolic function, and elevated pulmonary artery pressures. *What is your diagnosis?* [image: First page PDF preview]
Costs and Health Care Burden of Cerumen Extraction
Costs and Health Care Burden of Cerumen Extraction: This cross-sectional study quantifies the cost burden and health care burden of cerumen extraction among Medicare recipients in the United States. *Importance* Cerumen extractions are performed in a large portion of otolaryngology and head and neck surgery practices. The burden on the health care system of cerumen extractions is unknown and demographics have not been characterized at a population level. *Objective* To quantify the cost burden and health care burden of cerumen extraction among Medicare recipients in the United S...περισσότερα »
Bronchoscopy in Percutaneous Dilational Tracheostomy
Bronchoscopy in Percutaneous Dilational Tracheostomy: This cohort study evaluates the use of bronchoscopy for placement of percutaneous dilation tracheostomy, focusing on postprocedural complications and hospital length of stay. *Importance* A modified percutaneous dilational tracheostomy (PDT) is a relatively new alternative method of performing PDTs in which tissues overlying the trachea are dissected, but needle entry is still performed blindly. Many centers use bronchoscopy-assisted PDT, but the necessity of bronchoscope assistance for modified PDTs has not been examined. D...περισσότερα »
Intracapsular Tonsillectomy in Children With Sleep Apnea
Intracapsular Tonsillectomy in Children With Sleep Apnea: This case series study assesses the effectiveness of powered intracapsular tonsillectomy and adenoidectomy in patients with severe obstructive sleep apnea as evidenced by polysomnographic parameter changes. *Importance* Powered intracapsular tonsillectomy and adenoidectomy (PITA) is an increasingly common pediatric procedure. Few studies have examined its effectiveness in children with severe obstructive sleep apnea (OSA). *Objective* To assess the effectiveness of PITA in patients with severe OSA as evidenced by change i... περισσότερα »
Meniere’s disease : Intratympanic Dexamethazone plus High Dosage of Betahistine
Treatment of Meniere’s disease with via American Journal of Otolaryngology Publication date: Available online 30 December 2015 *Source:*American Journal of Otolaryngology Author(s): Silviu Albu, Alina Nagy, Caius Doros, Luigi Marceanu, Sebastian Cozma, Gabriela Musat, Franco Trabalzini PurposeThe aim of the present study was to assess if the combined therapy of intratympanic dexamethasone (ITD) and high dosage of betahistine (HDBH) is able to provide increased vertigo control compared to ITD alone in patients suffering from definite unilateral Meniere’s disease (MD).Materials and Meth...περισσότερα »
Sepsis detection and monitoring
Sepsis detection and monitoring in EMS: For EMS providers to truly understand sepsis, they must also understand the systemic inflammatory response syndrome (SIRS) cascade. SIRS, as a term to describe the complex physiological response to insult, first originated at a critical care medicine conference in 1991 [1]. By establishing a conceptual framework for this progressive injurious process, researchers laid the groundwork for the study of SIRS and its sequelae. *What is sepsis?* SIRS is an inflammatory response that affects the entire body rather than a localized area [1]. A varie... περισσότερα »
Ventilating difficult airways
Ventilating difficult airways in the field: EMS providers perform a myriad of functions while attending to patients in the field. Perhaps the most critical and intensive set of tasks are identifying and managing the airway of a patient who is unable to spontaneously maintain patency. There are a wide range of airway tools and equipment available in the EMS marketplace to accomplish these tasks. This article will focus on tools and procedures that support the patient's ventilatory capacity. *Crash airway is a given in EMS* Out of hospital airway management should be approached with... περισσότερα »
cVEMP and oVEMPs in evaluation of BPPV
Efficacy of cervical and ocular vestibular-evoked myogenic potentials in evaluation of benign paroxysmal positional vertigo of posterior semicircular canal: AbstractBenign paroxysmal positional vertigo (BPPV) constitutes a major proportion of the population with peripheral vestibulopathies. Although the freely floating otoconia within the semicircular canals is responsible for the symptoms of BPPV, the source of the otoconia debris is mainly believed to be the otolith organs. Therefore, the pathology in either or both the otolith organs appears a logical proposition. Cervical and o... περισσότερα »
Hereditary hemorrhagic telangiectasia (HHT) : Technique modifications for septodermoplasty
Technique modifications for septodermoplasty: an illustrative case: Abstract BackgroundHereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease that results in telangiectasia of the sinonasal tract, gastro-intestinal tract as well as possible arteriovenous malformations of the lung, liver and brain. One of the most common disease manifestations of HHT is epistaxis. Severe recurrent epistaxis necessitating iron therapy and blood transfusion is often managed with septodermoplasty. Its initial description was as an open surgical technique requiring nasal packing. ...περισσότερα »
The neurovascular bundle (NVB) position with cone-beam computerized tomography (CBCT)
Evaluation of the neurovascular bundle position at the palate with cone beam computed tomography: an observational study: Abstract BackgroundThe aim of this study was to investigate the neurovascular bundle (NVB) position with cone-beam computerized tomography (CBCT). MethodsCBCT images of 345 patients were evaluated. The distance from the neurovascular bundle to the cemento-enamel junction (CEJ) was measured (DNB). The distance from mid-palatal suture to the alveolar crest was used to determine the palatal depth. Palatal junction angle (PA) was measured using the junction angl... περισσότερα »
Congenital sternoclavicular dermoid sinus
Congenital sternoclavicular dermoid sinus: We report a case series of 8 patients, presenting with a congenital sinus in the region of the sternoclavicular joint. This rare malformation has only been reported in the Japanese dermatological literature under the name of “congenital dermoid fistula of the anterior chest region”. It has to be distinguished from other congenital anomalies and requires complete excision.
Radiological Criteria to Diagnose Large Vestibular Aqueduct Syndrome
Evaluation of the Radiological Criteria to Diagnose Large Vestibular Aqueduct Syndrome: The main objective of the current work is to increase the sensitivity of the radiological diagnosis of the large vestibular aqueduct syndrome (LVAS). The specific aims were to compare between the two famous criteria to diagnose large vestibular aqueduct (LVA), (i.e.,Valvassori and Cincinnati), to correlate between vestibular aqueduct (VA) measurements in the axial view and those in 45° oblique reformate in children with LVAS, and to define radiological criteria to diagnose LVA in the 45° oblique ... περισσότερα »
Dedifferentiated Chondrosarcoma of the Larynx
Dedifferentiated Chondrosarcoma of the Larynx: AbstractPrimary dedifferentiated chondrosarcoma occurring in the larynx is a rare head and neck malignancy. The cases reported in the literature suggest male gender predilection and variable clinical outcomes ranging from disease-free survival to disease-related death. Although a calcified matrix is suggestive of chondrosarcoma, the dedifferentiated component is not readily appreciated on conventional imaging modalities and thorough tissue sampling is necessary for confirming the diagnosis. Histologically, there is an abrupt transition... περισσότερα »
Evolution of Patients With Immediate Complete Facial Paralysis Secondary to Acoustic Neuroma Surgery
Evolution of Patients With Immediate Complete Facial Paralysis Secondary to Acoustic Neuroma Surgery: Objective: To study the evolution of patients with immediate complete facial paralysis after acoustic neuroma surgery in different scenarios and assess different facial reanimations techniques. Methods: This study included 50 patients with complete facial paralysis immediately after acoustic neuroma surgery. Data were analyzed into 4 groups according to the need and type of reconstruction of the facial nerve, either none, immediate, or on a deferred basis. All patients had intraope... περισσότερα »
Metformin Attenuates 131I-Induced Decrease in Peripheral Blood Cells in Patients with Differentiated Thyroid Cancer
Metformin Attenuates 131I-Induced Decrease in Peripheral Blood Cells in Patients with Differentiated Thyroid Cancer: Thyroid , Vol. 0, No. 0. Author information Athanasios Bikas,1,2 Douglas Van Nostrand,3 Kirk Jensen,4 Sameer Desale,2 Mihriye Mete,2 Aneeta Patel,4 Leonard Wartofsky,1 Vasyl Vasko,4 and Kenneth D. Burman1 1Division of Endocrinology, Department of Medicine, MedStar Washington Hospital Center, Washington, DC. 2MedStar Health Research Institute, Washington, DC. 3Department of Nuclear Medicine, MedStar Washington Hospital Center, Washington, DC. 4Department of Pediatrics... περισσότερα »
Recurrence after Definitive Surgery of Locally Invasive Well-Differentiated Papillary Thyroid Carcinoma
Treatment Outcomes and Risk Factors for Recurrence after Definitive Surgery of Locally Invasive Well-Differentiated Papillary Thyroid Carcinoma: Thyroid , Vol. 0, No. 0. Author information Ji Won Kim,1 Jong-Lyel Roh,1 Gyungyup Gong,2 Kyung-Ja Cho,2 Seung-Ho Choi,1 Soon Yuhl Nam,1 andSang Yoon Kim1 1Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 2Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Address correspondence to: *Jong-Lyel Roh, MD* *Departme... περισσότερα »
Mast Cell and Glands in Chronic Tonsillitis
Histological and Histochemical Observations on Mast Cell and Glands in Chronic Tonsillitis: AbstractMast cell take active part in immune system of body, clinical manifestations are closely related to hypersensitivity. Reactions and potent biological mediators released by these cells are responsible for different clinical manifestation like allergic reaction. Frequent and important sites of these allergic reactions occur in—upper aero digestive tract, nasal, pharyngeal and respiratory allergies. The study aims to demonstrate different types of heparin in mast cells having role in t... περισσότερα »
Cardiovascular Response to Manual Acupuncture Needle Stimulation among Apparently Healthy Nigerian Adults
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 38 δευτερόλεπτα
Publication date: Available online 30 December 2015 Source:Journal of Acupuncture and Meridian Studies Author(s): Ganiyu Sokunbi, Stanley Maduagwu, Olabode Jaiyeola, Hassan Gambo, Cephas Blasu This study investigated experience with acupuncture needle stimulation of apparently healthy adult Nigerians and the responses of the systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and rate […]
Cardiovascular Response to Manual Acupuncture Needle Stimulation among Apparently Healthy Nigerian Adults
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 38 δευτερόλεπτα
Publication date: Available online 30 December 2015 Source:Journal of Acupuncture and Meridian Studies Author(s): Ganiyu Sokunbi, Stanley Maduagwu, Olabode Jaiyeola, Hassan Gambo, Cephas Blasu This study investigated experience with acupuncture needle stimulation of apparently healthy adult Nigerians and the responses of the systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and rate […]
Constipation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 38 δευτερόλεπτα
Constipation: Infrequent and frequently incomplete bowel movements. Constipation is the opposite of diarrhea and is commonly caused by irritable bowel syndrome (IBS), diverticulosis, and medications. Paradoxically, constipation can also be caused by overuse of laxatives. Colon cancer can also narrow the colon and thereby cause constipation. A high-fiber diet can frequently relieve constipation. If the […]
Constipation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 38 δευτερόλεπτα
Constipation: Infrequent and frequently incomplete bowel movements. Constipation is the opposite of diarrhea and is commonly caused by irritable bowel syndrome (IBS), diverticulosis, and medications. Paradoxically, constipation can also be caused by overuse of laxatives. Colon cancer can also narrow the colon and thereby cause constipation. A high-fiber diet can frequently relieve constipation. If the […]
Boreal peatland water table depth and carbon accumulation during the Holocene thermal maximum, Roman Warm Period, and Medieval Climate Anomaly
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 38 δευτερόλεπτα
Publication date: 15 February 2016 Source:Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 444 Author(s): James R. Holmquist, Robert K. Booth, Glen M. MacDonald The Boreal Shield and James Bay Lowland regions of Ontario have few Holocene reconstructions specific to surface moisture despite their potential importance to documenting the geographic patterns and teleconnections of Holocene pluvials and droughts, as […]
Boreal peatland water table depth and carbon accumulation during the Holocene thermal maximum, Roman Warm Period, and Medieval Climate Anomaly
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 38 δευτερόλεπτα
Publication date: 15 February 2016 Source:Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 444 Author(s): James R. Holmquist, Robert K. Booth, Glen M. MacDonald The Boreal Shield and James Bay Lowland regions of Ontario have few Holocene reconstructions specific to surface moisture despite their potential importance to documenting the geographic patterns and teleconnections of Holocene pluvials and droughts, as […]
Editorial Board
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 38 δευτερόλεπτα
Publication date: 15 March 2016 Source:Journal of Hazardous Materials, Volume 305 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Py9BJv via IFTTT
Vas Narasimhan
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Nature Reviews Drug Discovery 15, 10 (2016). doi:10.1038/nrd.2015.33 Vas Narasimhan, global head of development at Novartis, discusses his plans to increase the efficiency and reduce the cost of trial execution. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R0kwNz via IFTTT
Vitamin D status as a synthetic biomarker of health status
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
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Cancer: Engineered T cells gain access to pancreatic tumours
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Nature Reviews Drug Discovery 15, 16 (2016). doi:10.1038/nrd.2015.40 Author: Alexandra Flemming Pancreatic ductal adenocarcinoma (PDA) is the most common form of pancreatic cancer and has a particularly low survival rate. PDA induces robust desmoplasia, thereby creating a barrier to drug penetration and antitumour immunity. Now, reporting in Cancer Cell, Stromnes et al. describe the from […]
Effects of Serine 129 phosphorylation on {alpha}-synuclein aggregation, membrane association, and internalization Cell Biology
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Although trace levels of phosphorylated α-synuclein (α-syn) are detectable in normal brains, nearly all α-syn accumulated within Lewy bodies in Parkinson′s disease brains is phosphorylated on serine 129 (S129). The role of the phosphoserine residue and its effects on α-syn structure, function, and intracellular accumulation are poorly understood. Here, co-expression of α-syn and polo-like kinase […]
Amyloid-{beta} receptors: the good, the bad and the prion protein Cell Biology
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Several different receptor proteins have been identified that bind monomeric, oligomeric or fibrillar forms of amyloid-β (Aβ). ″Good″ receptors internalise Aβ or promote its transcytosis out of the brain, whereas ″bad″ receptors bind oligomeric forms of Aβ that are largely responsible for the synaptic loss, memory impairments and neurotoxicity which underlie Alzheimer′s disease. The prion […]
Antiviral drugs: HSP70 inhibitor blocks virus replication
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Nature Reviews Drug Discovery 15, 18 (2016). doi:10.1038/nrd.2015.31 Author: Sarah Crunkhorn Host molecular chaperones are reported to facilitate the replication of flaviviruses such as dengue virus (DENV). Here, Taguwa et al. show that cytosolic heat shock protein 70 (HSP70) isoforms and their DNAJ cofactors facilitate multiple steps of the DENV life cycle, including viral entry, […]
Implications of exercise-induced adipo-myokines in bone metabolism
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Abstract Physical inactivity has been recognized, by the World Health Organization as the fourth cause of death (5.5 % worldwide). On the contrary, physical activity (PA) has been associated with improved quality of life and decreased risk of several diseases (i.e., stroke, hypertension, myocardial infarction, obesity, malignancies). Bone turnover is profoundly affected from PA both […]
G protein-coupled receptors: Illuminating orphan GPCRs
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Nature Reviews Drug Discovery 15, 15 (2016). doi:10.1038/nrd.2015.32 Author: Sarah Crunkhorn G protein-coupled receptors (GPCRs) have a central role in physiology and disease and represent the most productive drug targets. However, more than 100 non-olfactory GPCRs are ‘orphan’ receptors whose endogenous ligands, and often physiological roles, remain unknown. Here, Roth, Shoichet and colleagues describe an […]
Identification and validation of biomarkers for autism spectrum disorders
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Nature Reviews Drug Discovery 15, 70 (2016). doi:10.1038/nrd.2015.7 Authors: Eva Loth, Will Spooren, Lindsay M. Ham, Maria B. Isaac, Caroline Auriche-Benichou, Tobias Banaschewski, Simon Baron-Cohen, Karl Broich, Sven Bölte, Thomas Bourgeron, Tony Charman, David Collier, Fernando de Andres-Trelles, Sarah Durston, Christine Ecker, Andre Elferink, Marion Haberkamp, Robert Hemmings, Mark H. Johnson, Emily J. H. Jones, […]
Rupture of the sheath of the extensor carpi ulnaris tendon in a patient affected by rheumatoid arthritis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
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Regulation of c-Maf and {alpha}A-crystallin in Ocular Lens by FGF Signaling Developmental Biology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Fibroblast growth factor (FGF) signaling regulates a multitude of cellular processes, including cell proliferation, survival, migration, and differentiation. In the vertebrate lens, FGF signaling regulates fiber cell differentiation characterized by high expression of crystallin proteins. However, a direct link between FGF signaling and crystallin gene transcriptional machinery remains to be established. Previously, we have shown […]
Structural and mechanistic insights into the regulation of the fundamental Rho-regulator RhoGDI{alpha} by lysine acetylation Protein Structure and Folding
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Rho-proteins are small GTP/GDP-binding proteins primarily involved in cytoskeleton regulation. Their GTP/GDP-cycle is often tightly connected to a membrane/cytosol-cycle regulated by the Rho guanine nucleotide dissociation inhibitor α (RhoGDIα). RhoGDIα has been regarded as a housekeeping regulator essential to control homeostasis of Rho-proteins. Recent proteomic screens showed that RhoGDIα is extensively lysine acetylated. Here, we […]
Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin Enzymology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The membrane-anchored serine prostasin (CAP1/PRSS8) is essential for barrier acquisition of the interfollicular epidermis and for normal hair follicle development. Consequently, prostasin null mice die shortly after birth. Prostasin is found in two forms in the epidermis: a one-chain zymogen and a two-chain proteolytically active form, generated by matriptase-dependent activation site cleavage. Here we used […]
The E3-ubiquitin ligase adaptor protein Skp1 is glycosylated by an evolutionarily conserved pathway that regulates protist growth and development Microbiology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Toxoplasma gondii is a protist parasite of warm-blooded animals that causes disease by proliferating intracellularly in muscle and the central nervous system. Previous studies showed that a prolyl 4-hydroxylase related to animal HIFα prolyl hydroxylases is required for optimal parasite proliferation, especially at low O2. We also observed that Pro154 of Skp1, a subunit of […]
Deletion of Mbtps1 (PCSK8, S1P, SKI-1) in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age Metabolism
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Conditional deletion of Mbtps1 (cKO) protease in bone osteocytes leads to an age-related increase in mass (12%) and in contractile force (30%) in adult slow twitch soleus muscles (SOL) with no effect on fast twitch extensor digitorum longus muscles (EDL). Surprisingly, 10-12 month old bone from cKO animals was indistinguishable from controls in size, density, […]
Configuration-dependent presentation of multivalent IL-15:IL-15R{alpha} enhances the antigen-specific T cell response and anti-tumor immunity Molecular Biophysics
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Here we report on a «configuration-dependent» mechanism of action for IL-15:IL-15Rα (heterodimeric IL-15, or hetIL-15), where the manner by which IL-15:IL-15Rα molecules are presented to target cells significantly impacts its function as a vaccine adjuvant. While the cellular mechanism of IL-15 transpresentation via IL-15Rα and its importance for IL-15 function have been described, the full […]
Cytochrome P450 17A1 Interactions with the FMN Domain of its Reductase as Characterized by NMR Enzymology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
To accomplish key physiological processes from drug metabolism to steroidogenesis, human microsomal cytochrome P450 enzymes require the sequential input of two electrons delivered by the FMN domain of NADPH-cytochrome P450 reductase (CPR). Although some human microsomal P450 enzymes can instead accept the second electron from cytochrome b5, for human steroidogenic CYP17A1, the CPR FMN domain […]
Activated ErbB3 translocates to the nucleus via clathrin-independent endocytosis which is associated with proliferating cells Cell Biology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Members of the receptor tyrosine kinase family (RTK) have been shown to be present in the nucleus of cells; however, the mechanisms underlying their trafficking to the nucleus, and their relevance once there are poorly understood. In the present study, we focus on the RTK ErbB3 and elucidate the mechanisms regulating its trafficking. We show […]
Myozap Deficiency Promotes Adverse Cardiac Remodeling via Differential Regulation of MAPK/SRF- and {beta}-Catenin/GSK-3{beta}-Signaling Signal Transduction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The intercalated disc (ID) is a ″hot spot″ for heart disease, as several ID proteins have been found mutated in cardiomyopathy. Myozap is a recent addition to the list of ID proteins, and has been implicated in SRF signaling. To elucidate the cardiac consequences of targeted deletion of Myozap in vivo we generated Myozap null […]
Amyloid-{beta} receptors: the good, the bad and the prion protein Cell Biology
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Several different receptor proteins have been identified that bind monomeric, oligomeric or fibrillar forms of amyloid-β (Aβ). ″Good″ receptors internalise Aβ or promote its transcytosis out of the brain, whereas ″bad″ receptors bind oligomeric forms of Aβ that are largely responsible for the synaptic loss, memory impairments and neurotoxicity which underlie Alzheimer′s disease. The prion […]
First identification of Tn916-like element in industrial strains of Lactobacillus vini that spread the tet-M resistance gene
The open process used to ferment sugar cane juice or molasses to produce ethanol fuel is prone to contamination by bacterial cells of different species, in particular Lactobacilli. The situation can be exacerbated by the emergence of resistant cells to industrial antibiotics that are normally used to combat this contamination. In this work, two *Lactobacillus vini* isolates from ethanol distilleries were identified and found to be resistant to doxycycline, a tetracycline-derivative, although sensitive to other antibiotics tested. The identification of these isolates was confirmed ... περισσότερα »
Pénétration microbienne dans la connectique pilier-implant : revue de littérature
Publication date: Available online 30 December 2015 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): S. Baixe, H. Tenenbaum, O. Etienne La qualité de fabrication des pièces implantaires permet actuellement d'assurer une coaptation de quelques microns entre le col de l'implant et le pilier prothétique. Cet espace (microgap en anglais) s'ouvre et se ferme lorsqu'il est soumis à des forces occlusales, créant un mouvement de pompage vis-à-vis des micro-organismes et des fluides buccaux environnants et aboutissant à une possible contamination ...περισσότερα »
Mediators between education and dental pain: a cross-sectional study to assess the role of dental services utilization
This study tested whether the pattern of dental services utilization and the reason for the last dental visit mediate the association between educational attainment and dental pain. This is a cross-sectional analysis ( *n* = 1099) based on data from a prospective cohort study in adults, southern Brazil. The mediating effects were assessed by including interaction terms in logistic regression models and by the KHB method, which estimated the direct, mediated, and total effects of education on dental pain. The prevalence of dental pain was 17.5%. Individuals with less than 12 yr of ... περισσότερα »
Systematic review of the in vitro effects of statins on oral and perioral microorganisms
Statins are medications administered orally and are widely used for lowering the blood cholesterol level. The aim of this study was to investigate the effects of orally administered statins on microorganisms infecting oral and perioral tissues. We performed a systematic review of published studies of the in vitro antimicrobial effects of statins on bacteria, viruses, and fungi, and searched PubMed, Web of Science, Cochrane Central, and Google scholar. Studies show that most statins exhibit antimicrobial effects against various oral microorganisms. Simvastatin is most effective ag... περισσότερα »
Evaluation of the neurovascular bundle position at the palate with cone beam computed tomography: an observational study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Background The aim of this study was to investigate the neurovascular bundle (NVB) position with cone-beam computerized tomography (CBCT). Methods CBCT images of 345 patients were evaluated. The distance from the neurovascular bundle to the cemento-enamel junction (CEJ) was measured (DNB). The distance from mid-palatal suture to the alveolar crest was used to determine […]
Chronic hypersensitivity pneumonitis caused by Saccharopolyspora rectivirgula is not associated with a switch to a Th2 response.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Hypersensitivity Pneumonitis is an interstitial lung disease that develops following repeated exposure to inhaled environmental antigens. The disease results in alveolitis, granuloma formation and progresses to a chronic form associated with fibrosis; a greater understanding of the immunopathogenic mechanisms leading to chronic HP is needed. We used the Saccharopolyspora rectivirgula (SR) mouse model of HP […]
MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type – 1 induced defective autophagy in vitro
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder and some HPS patients develop pulmonary fibrosis known as HPS associated interstitial pneumonia (HPSIP). We have previously reported that HPSIP is associated with severe surfactant accumulation, lysosomal stress and alveolar epithelial cell type II (AECII) apoptosis. Here, we hypothesized that defective autophagy might result in excessive […]
Regulation of Alveolar Septation by MicroRNA-489
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
MicroRNAs are small conserved RNA that regulate gene expression. Bioinformatic analysis of miRNA profiles during mouse lung development indicated a role for multiple microRNA including microRNA-489 (miR-489). miR-489 increased on completion of alveolar septation (Postnatal day 42 (P42)), associated with decreases in its conserved target genes Insulin-like Growth Factor-1 [Igf1] and Tenascin-C [Tnc]. We hypothesized […]
Mucosal inflammation at the respiratory interface: a zebrafish model
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Inflammatory diseases of the respiratory system such as asthma and chronic obstructive pulmonary disease are increasing globally and remain poorly understood conditions. While attention has long focused on the activation of type 1 and type 2 helper T cells of the adaptive immune system in these diseases, it is becoming increasingly apparent that there is […]
Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Recent data indicate a role for airway epithelial necroptosis, a regulated form of necrosis, and the associated release of damage associated molecular patterns (DAMPs) in the development of COPD. DAMPs can activate pattern recognition receptors (PRRs), triggering innate immune responses. We hypothesized that cigarette smoke (CS)-induced epithelial necroptosis and DAMP release initiate airway inflammation in […]
Adrenal congestion preceding adrenal hemorrhage on CT imaging: a case series
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Introduction Adrenal hemorrhage is an uncommon but potentially life-threatening condition, particularly in cases of bilateral adrenal hemorrhage causing primary adrenal insufficiency. It is difficult to diagnose clinically, particularly in critically ill patients, given its non-specific symptoms and signs, which include abdominal pain, vomiting, fever, weakness, hypotension, and altered conscious state. Non-traumatic adrenal hemorrhage has […]
Neuroendocrine carcinoma of the stomach: clinical features and CT findings
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Purpose The purpose of the study is to investigate the computed tomographic characteristic and clinical findings of gastric neuroendocrine carcinoma (G-NEC) to increase awareness of this disease. Methods Twenty-two patients with a diagnosis of G-NEC were identified through the PACS of our hospital from August 2010 to November 2014. The clinical data, computed tomography […]
Diffusion-weighted imaging (DWI) of the liver in assessing chronic liver disease: effects of the presence and the degree of ascites on ADC values
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Purpose The aim of this study was to determine the correlation between the liver and spleen apparent diffusion coefficient (ADC) values of patients with chronic liver disease and the presence and the degree of ascites. Materials and method In this retrospective study, we assessed 107 patients with chronic liver disease and 39 control subjects […]
Prognostic significance of parameters from pretreatment 18 F-FDG PET in hepatocellular carcinoma: a meta-analysis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Purpose The prognostic value of 18F-deoxyglucose positron emission tomography (18F-FDG PET) on hepatocellular carcinoma (HCC) remains inconclusive. This study aims to investigate the prognostic role of pretreatment 18F-FDG PET on HCC patients by meta-analysis. Methods PubMed, Embase, Cochrane library, and Wanfang databases were searched until June 2015. Hazard ratios (HRs) with corresponding 95% confidence […]
Rupture of the sheath of the extensor carpi ulnaris tendon in a patient affected by rheumatoid arthritis
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1NWD5MC via IFTTT
Vitamin D status as a synthetic biomarker of health status
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1R9wYcb via IFTTT
Implications of exercise-induced adipo-myokines in bone metabolism
Abstract Physical inactivity has been recognized, by the World Health Organization as the fourth cause of death (5.5 % worldwide). On the contrary, physical activity (PA) has been associated with improved quality of life and decreased risk of several diseases (i.e., stroke, hypertension, myocardial infarction, obesity, malignancies). Bone turnover is profoundly affected from PA both… Continue reading Implications of exercise-induced adipo-myokines in bone metabolism
Cathepsin D: an M{phi}-derived factor mediating increased endothelial cell permeability with implications for alteration of the blood-retinal barrier in diabetic retinopathy Research Communication
Inflammation plays an important role in the pathogenesis of diabetic retinopathy (DR). We have previously reported increased monocyte (Mono) trafficking into the retinas of diabetic animals. In this study, we have examined the effect of activated Monos on retinal endothelial cells (ECs). The U937 M-conditioned media (CMs) significantly decreased the transendothelial resistance of EC monolayers… Continue reading Cathepsin D: an M{phi}-derived factor mediating increased endothelial cell permeability with implications for alteration of the blood-retinal barrier in diabetic retinopathy ... περισσότερα »
APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation Research Communication
Besides its crucial role in the pathogenesis of Alzheimer’s disease, the knowledge of amyloid precursor protein (APP) physiologic functions remains surprisingly scarce. Here, we show that APP regulates the transcription of the glial cell line-derived neurotrophic factor (GDNF). APP-dependent regulation of GDNF expression affects muscle strength, muscular trophy, and both neuronal and muscular differentiation fundamental… Continue reading APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation Research Communication
{mu}-Crystallin controls muscle function through thyroid hormone action Research Communication
μ-Crystallin (Crym), a thyroid hormone-binding protein, is abnormally up-regulated in the muscles of patients with facioscapulohumeral muscular dystrophy, a dominantly inherited progressive myopathy. However, the physiologic function of Crym in skeletal muscle remains to be elucidated. In this study, Crym was preferentially expressed in skeletal muscle throughout the body. Crym-knockout mice exhibited a significant hypertrophy… Continue reading {mu}-Crystallin controls muscle function through thyroid hormone action Research Communication
The higher level of complexity of K-Ras4B activation at the membrane Research Communication
Is nucleotide exchange sufficient to activate K-Ras4B? To signal, oncogenic rat sarcoma (Ras) anchors in the membrane and recruits effectors by exposing its effector lobe. With the use of NMR and molecular dynamics (MD) simulations, we observed that in solution, farnesylated guanosine 5′-diphosphate (GDP)-bound K-Ras4B is predominantly autoinhibited by its hypervariable region (HVR), whereas the… Continue reading The higher level of complexity of K-Ras4B activation at the membrane Research Communication
Long-term efficacy and safety of incobotulinumtoxinA and conventional treatment of poststroke arm spasticity: a prospective, non-interventional, open-label, parallel-group study
Objective To compare the efficacy and safety of incobotulinumtoxinA with conventional antispastic therapy for poststroke arm spasticity in routine clinical practice over a 1-year period. Design Prospective, non-interventional, open-label, parallel-group study. Setting 47 centres in Germany. Participants Patients with poststroke arm spasticity; 108 receiving incobotulinumtoxinA, 110 conventional therapy. Intervention Conventional antispastic treatment including oral antispastic… Continue reading Long-term efficacy and safety of incobotulinumtoxinA and conventional treatment of postst... περισσότερα »
Monitoring adverse events in Norwegian hospitals from 2010 to 2013
Objectives To describe how adverse event (AE) rates were monitored and estimated nationally across all Norwegian hospitals from 2010 to 2013, and how they developed during the monitoring period. Monitoring was based on medical record review with Global Trigger Tool (GTT). Setting All publicly and privately owned hospitals were mandated to review randomly selected medical… Continue reading Monitoring adverse events in Norwegian hospitals from 2010 to 2013
Patient satisfaction and perceived quality of care: evidence from a cross-sectional national exit survey of HIV and non-HIV service users in Zambia
Objective To examine the associations between perceived quality of care and patient satisfaction among HIV and non-HIV patients in Zambia. Setting Patient exit survey conducted at 104 primary, secondary and tertiary health clinics across 16 Zambian districts. Participants 2789 exiting patients. Primary independent variables Five dimensions of perceived quality of care (health personnel practice and… Continue reading Patient satisfaction and perceived quality of care: evidence from a cross-sectional national exit survey of HIV and non-HIV service users in Zambia
Does a research article’s country of origin affect perception of its quality and relevance? A national trial of US public health researchers
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objectives The source of research may influence one’s interpretation of it in either negative or positive ways, however, there are no robust experiments to determine how source impacts on one’s judgment of the research article. We determine the impact of source on respondents’ assessment of the quality and relevance of selected research abstracts. Design Web-based […]
Compliance with the proper use of an individual radiation dosimeter among children and the effects of improper use on the measured dose: a retrospective study 18-20 months following Japan’s 2011 Fukushima nuclear incident
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objectives To identify profiles of children who did not properly use individual radiation dosimeters following Japan’s 2011 Fukushima nuclear incident, and to assess how much error is generated by improper dosimeter use. Participants The participants in this study comprised 1637 school children who participated in the external radiation exposure screening programme administrated by Minamisoma City […]
Systems science and systems thinking for public health: a systematic review of the field
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objectives This paper reports on findings from a systematic review designed to investigate the state of systems science research in public health. The objectives were to: (1) explore how systems methodologies are being applied within public health and (2) identify fruitful areas of activity. Design A systematic review was conducted from existing literature that draws […]
Does a research article’s country of origin affect perception of its quality and relevance? A national trial of US public health researchers
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objectives The source of research may influence one’s interpretation of it in either negative or positive ways, however, there are no robust experiments to determine how source impacts on one’s judgment of the research article. We determine the impact of source on respondents’ assessment of the quality and relevance of selected research abstracts. Design Web-based […]
Cigarette smoking susceptibility among youth alternate tobacco product users: implications of flavoured tobacco from a national cross-sectional Canadian sample (YSS 2012/2013)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objectives Declines in cigarette smoking have been accompanied by increases in alternative tobacco product (ATP) use, particularly among youth. This study examines smoking susceptibility and ATP use in a national sample of Canadian youth. Methods Data from grades 9–12 students who participated in the 2012/2013 Youth Smoking Survey, a nationally generalisable sample of Canadian students […]
A cluster-randomised controlled trial integrating a community-based water, sanitation and hygiene programme, with mass distribution of albendazole to reduce intestinal parasites in Timor-Leste: the WASH for WORMS research protocol
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Introduction There is limited evidence demonstrating the benefits of community-based water, sanitation and hygiene (WASH) programmes on infections with soil-transmitted helminths (STH) and intestinal protozoa. Our study aims to contribute to that evidence base by investigating the effectiveness of combining two complementary approaches for control of STH: periodic mass administration of albendazole, and delivery of […]
Systems science and systems thinking for public health: a systematic review of the field
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objectives This paper reports on findings from a systematic review designed to investigate the state of systems science research in public health. The objectives were to: (1) explore how systems methodologies are being applied within public health and (2) identify fruitful areas of activity. Design A systematic review was conducted from existing literature that draws […]
Research is ‘a step into the unknown: an exploration of pharmacists perceptions of factors impacting on research participation in the NHS
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objective This study explored National Health Service (NHS) pharmacists’ perceptions and experiences of pharmacist-led research in the workplace. Design Semistructured, face-to-face discussions continued until distinct clusters of opinion characteristics formed. Verbatim transcripts of audio-recordings were subjected to framework analysis. Setting Interviews were carried out with 54 pharmacists with diverse backgrounds and roles from general practices […]
Cigarette smoking susceptibility among youth alternate tobacco product users: implications of flavoured tobacco from a national cross-sectional Canadian sample (YSS 2012/2013)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objectives Declines in cigarette smoking have been accompanied by increases in alternative tobacco product (ATP) use, particularly among youth. This study examines smoking susceptibility and ATP use in a national sample of Canadian youth. Methods Data from grades 9–12 students who participated in the 2012/2013 Youth Smoking Survey, a nationally generalisable sample of Canadian students […]
Balance ability in 7- and 10-year-old children: associations with prenatal lead and cadmium exposure and with blood lead levels in childhood in a prospective birth cohort study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objectives Most studies reporting evidence of adverse effects of lead and cadmium on the ability to balance have been conducted in high-exposure groups or have included adults. The effects of prenatal exposure have not been well studied, nor have the effects in children been directly studied. The aim of the study was to identify the […]
Extranodal follicular dendritic cell sarcoma involving tonsil.
Related Articles *Extranodal follicular dendritic cell sarcoma involving tonsil.* Malays J Pathol. 2015 Dec;37(3):293-9 Authors: Kulkarni MP, Momin YA, Deshmukh BD, Sulhyan KR Abstract Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm arising from lymph nodes as well as extranodal sites. Despite the characteristic histopathological features and distinctive immunophenotype, extranodal FDCS are often misdiagnosed initially as undifferentiated carcinoma, inflammatory pseudotumour, meningioma, metastatic malignant melanoma, ectopic thymoma, etc., because of its rarity and l...περισσότερα »
Hb lepore/β(0)-thalassaemia with α(+)-thalassaemia interactions, a potential diagnostic pitfall.
Related Articles *Hb lepore/β(0)-thalassaemia with α(+)-thalassaemia interactions, a potential diagnostic pitfall.* Malays J Pathol. 2015 Dec;37(3):287-92 Authors: Alauddin H, Mohamad Nasir S, Ahadon M, Raja Sabudin RZ, Ithnin A, Hussin NH, Alias H, Loh CH, Abdul Latiff Z, Abdul Murad NA, Othman A Abstract Haemoglobin (Hb) Lepore is a variant Hb consisting of two α-globin and two δβ-globin chains. In a heterozygote, it is associated with clinical findings of thalassaemia minor, but interactions with other haemoglobinopathies can lead to various clinical phenotypes and pose diagn... περισσότερα »
Malignant transformation of breast ductal adenoma: a diagnostic pitfall.
Related Articles *Malignant transformation of breast ductal adenoma: a diagnostic pitfall.* Malays J Pathol. 2015 Dec;37(3):281-5 Authors: Hayashi H, Ohtani H, Yamaguchi J, Shimokawa I Abstract We present what is believed to be the first report of heterogeneous carcinoma arising from breast ductal adenoma. A 57-year-old woman presented with a nodule in her right breast. Histological examination of a vacuum-assisted biopsy specimen revealed epithelial tubular proliferation and papillary apocrine epithelium. The myoepithelial cells lining the tubules were confirmed by immunohistoch...περισσότερα »
Double Philadelphia chromosome-positive B acute lymphoblastic leukaemia in an elderly patient.
Related Articles *Double Philadelphia chromosome-positive B acute lymphoblastic leukaemia in an elderly patient.* Malays J Pathol. 2015 Dec;37(3):275-9 Authors: Tang YL, Raja Sabudin RZ, Leong CF, Ko CC, Chia WK, Salwati S, Wong CL Abstract A rare case of double Philadelphia chromosome-positive B Acute lymphoblastic Leukaemia (B-ALL) is reported here. A 60-year-old lady presented with one month history of fever, submandibular lymphadenopathy, loss of appetite and weight loss. Physical examination revealed multiple palpable cervical lymph nodes. Blood film showed leucocytosis wit...περισσότερα »
Comparison of the Anaerocult A and the oil blocking methods for the in vitro cultivation of Entamoeba histolytica.
Related Articles *Comparison of the Anaerocult A and the oil blocking methods for the in vitro cultivation of Entamoeba histolytica.* Malays J Pathol. 2015 Dec;37(3):271-4 Authors: Mohd Shah NA, Wan Abdul Wahab WN, Mohd Nawi SF, Mohd-Zain Z, Latif B, Suhaimi R Abstract Entamoeba histolytica, the causative agent for human amoebiasis, is among the most deadly parasites, accounting for the second highest mortality rate among parasitic diseases. Because this parasite dwells in low oxygen tension, for its cultivation, microaerophilic conditions are required to mimick the human gut en...περισσότερα »
Cytological evaluation and significance of cell cannibalism in effusions and urine cytology.
Related Articles *Cytological evaluation and significance of cell cannibalism in effusions and urine cytology.* Malays J Pathol. 2015 Dec;37(3):265-70 Authors: Ahmed Wani F, Bhardwaj S Abstract Cell cannibalism is believed to be an indicator of high-grade aggressive cancers with increased metastatic potential. It denotes both anaplastic grade and invasiveness and is valuable in assessing tumor behavior. The present study was a 2-year retrospective and 1-year prospective study conducted in the Department of Pathology, Government Medical College, Jammu. PAP and MGG stained smears ...περισσότερα »
Suicide in the elderly in Malaysia.
Related Articles *Suicide in the elderly in Malaysia.* Malays J Pathol. 2015 Dec;37(3):259-63 Authors: Rahimi R, Ali N, Md Noor S, Mahmood MS, Zainun KA Abstract Suicidal feelings and a sense of hopelessness have been regarded as part of the ageing process more so in the context of being elderly and having physical difficulties. As older adults are the fastest growing population in the world, suicides among this population is also expected to increase. The authors retrospectively reviewed all cases recorded by the National Suicide Registry Malaysia (NSRM) for the year 2009. Suici... περισσότερα »
Minichromosome maintenance-2 (MCM2) expression differentiates oral squamous cell carcinoma from pre-cancerous lesions.
Related Articles *Minichromosome maintenance-2 (MCM2) expression differentiates oral squamous cell carcinoma from pre-cancerous lesions.* Malays J Pathol. 2015 Dec;37(3):253-8 Authors: Razavi SM, Jafari M, Heidarpoor M, Khalesi S Abstract BACKGROUND: Proteins necessary for DNA replication and normal regulation for the cell cycle include minichromosome maintenance-2 (Mcm-2). Overexpression of this protein in several premalignant and malignant lesions has been observed. In this study, the diagnostic value of Mcm-2 expression in distinguishing histologically-proven normal oral mucos... περισσότερα »
Haematological and biochemical markers as predictors of dengue infection.
Related Articles *Haematological and biochemical markers as predictors of dengue infection.* Malays J Pathol. 2015 Dec;37(3):247-51 Authors: Rashmi MV, Hamsaveena H Abstract Dengue is a viral infection which has become a serious problem in recent years. It is a major cause of mortality and morbidity. The present study is a prospective, hospital-based, observational study done from August 2014 to October 2014. The objective of our study was to consider whether dengue infection can be suspected based on haematological and biochemical findings. The study included 100 patients positi...περισσότερα »
A comparison of 1995 WHO classification with 2003 ISN/RPS classification of lupus nephritis: a single centre observation.
Related Articles *A comparison of 1995 WHO classification with 2003 ISN/RPS classification of lupus nephritis: a single centre observation.* Malays J Pathol. 2015 Dec;37(3):239-46 Authors: Chow TK, Looi LM, Cheah PL Abstract BACKGROUND: In the past, lupus nephritis was histologically classified according to the 1995 WHO Classification. With the introduction of the 2003 ISN/RPS Classification, many nephropathology services converted to this new classification. This study was undertaken to compare both classification systems in a single centre practice. METHODS: 103 consecutive ade... περισσότερα »
Serum fasting lipid profile in children and adolescents with β-thalassaemia major in southern Pakistan.
Related Articles *Serum fasting lipid profile in children and adolescents with β-thalassaemia major in southern Pakistan.* Malays J Pathol. 2015 Dec;37(3):233-8 Authors: Ashar S, Sultan S, Irfan Sm SM, Sheeraz A Abstract OBJECTIVE: Serum fasting lipid profile has been studied in various clinical spectrum of Beta (β)- thalassaemia syndrome. Premature cardiac impairment in thalassaemia major appears primarily due to iron accumulation and oxidative injury; however it might be a sequel of abnormal lipoprotein concentrations. The rational of this study is to analyse the serum fasting ... περισσότερα »
Molecular detection of the New Delhi metallo-β-lactamase-1 gene in Enterobacteriaceae isolates in a tertiary medical centre.
Related Articles *Molecular detection of the New Delhi metallo-β-lactamase-1 gene in Enterobacteriaceae isolates in a tertiary medical centre.* Malays J Pathol. 2015 Dec;37(3):227-32 Authors: Zainol Abidin NZ, Sulong A, Alfizah H, Muttaqillah NA, Ding CH Abstract BACKGROUND: New Delhi metallo-β-lactamase-1 (NDM-1) is a relatively recent carbapenemase enzyme that inactivates all β-lactam antibiotics with the exception of aztreonam. This study aims to ascertain the baseline prevalence and antibiotic susceptibility patterns of NDM-1-producing Enterobacteriaceae in a tertiary medical... περισσότερα »
Comparison of invasion by human microvascular endothelial cell lines in response to vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in a threedimensional (3D) cell culture system.
Related Articles *Comparison of invasion by human microvascular endothelial cell lines in response to vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in a threedimensional (3D) cell culture system.* Malays J Pathol. 2015 Dec;37(3):219-25 Authors: Ng CT, Yip WK, Mohtarrudin N, Seow HF Abstract BACKGROUND: Immortalized human endothelial cells are widely used as in vitro models for debilitating conditions such as cancer, cardiovascular and ocular diseases. Human microvascular endothelial cell (HMEC-1) is immortalized via stable transfection with a...περισσότερα »
Scientific misconduct encountered by APAME journals: an online survey.
Related Articles *Scientific misconduct encountered by APAME journals: an online survey.* Malays J Pathol. 2015 Dec;37(3):213-8 Authors: Looi LM, Wong LX, Koh CC Abstract In June 2015, invitations were sent by email to 151 APAME journals to participate in an online survey with an objective of gaining insight into the common publication misconduct encountered by APAME editors. The survey, conducted through SurveyMonkey over a 20-day-period, comprised 10 questions with expansions to allow anecdotes limited to 400 characters, estimated to take less than 10 minutes to complete. Only ... περισσότερα »
Spilling over: Partner parenting stress as a predictor of family cohesion in parents of adolescents with developmental disabilities
Publication date: February–March 2016 *Source:*Research in Developmental Disabilities, Volumes 49–50 Author(s): Darcy B. Mitchell, Alexandra Szczerepa, Penny Hauser-Cram Family cohesion relates to positive outcomes for both parents and children. Maintaining cohesion may be especially challenging for families of adolescents with developmental disabilities, yet this has been studied infrequently in this group. We investigated cohesion in these families, particularly with respect to partner stress, using the notion of the 'spillover effect' as a model.Adolescents with disabilities and t... περισσότερα »
Comparing participation in physical recreation activities between children with disability and children with typical development: A secondary analysis of matched data
Publication date: February–March 2016 *Source:*Research in Developmental Disabilities, Volumes 49–50 Author(s): Carmen Woodmansee, Andrew Hahne, Christine Imms, Nora Shields BackgroundFacilitating participation in physical recreation among children with disability is an increasingly important aim of paediatric rehabilitation.AimTo compare the extent (diversity and frequency), context (where and companionship), experience (enjoyment) and preference for participation in physical recreation activities outside-of-school between children with disability and children with typical developme... περισσότερα »
Social cognition makes an independent contribution to peer relations in children with Specific Language Impairment
Publication date: February–March 2016 *Source:*Research in Developmental Disabilities, Volumes 49–50 Author(s): Clara Andrés-Roqueta, Juan E. Adrian, Rosa A. Clemente, Lidón Villanueva BackgroundLanguage is important for developing and maintaining social relationships, and also for understanding others minds. Separate studies have shown that children with Specific Language Impairment (SLI) present difficulties in both abilities, although the role of social cognition (SC) on peers' perception remains unexplored.AimsThe present study aims to assess specific sociometric features of chi... περισσότερα »
Chronic hypersensitivity pneumonitis caused by Saccharopolyspora rectivirgula is not associated with a switch to a Th2 response.
Hypersensitivity Pneumonitis is an interstitial lung disease that develops following repeated exposure to inhaled environmental antigens. The disease results in alveolitis, granuloma formation and progresses to a chronic form associated with fibrosis; a greater understanding of the immunopathogenic mechanisms leading to chronic HP is needed. We used the Saccharopolyspora rectivirgula (SR) mouse model of HP… Continue reading Chronic hypersensitivity pneumonitis caused by Saccharopolyspora rectivirgula is not associated with a switch to a Th2 response.
MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type – 1 induced defective autophagy in vitro
Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder and some HPS patients develop pulmonary fibrosis known as HPS associated interstitial pneumonia (HPSIP). We have previously reported that HPSIP is associated with severe surfactant accumulation, lysosomal stress and alveolar epithelial cell type II (AECII) apoptosis. Here, we hypothesized that defective autophagy might result in excessive… Continue reading MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type – 1 induced defective autophagy in vitro
Regulation of Alveolar Septation by MicroRNA-489
MicroRNAs are small conserved RNA that regulate gene expression. Bioinformatic analysis of miRNA profiles during mouse lung development indicated a role for multiple microRNA including microRNA-489 (miR-489). miR-489 increased on completion of alveolar septation (Postnatal day 42 (P42)), associated with decreases in its conserved target genes Insulin-like Growth Factor-1 [Igf1] and Tenascin-C [Tnc]. We hypothesized… Continue reading Regulation of Alveolar Septation by MicroRNA-489
Mucosal inflammation at the respiratory interface: a zebrafish model
Inflammatory diseases of the respiratory system such as asthma and chronic obstructive pulmonary disease are increasing globally and remain poorly understood conditions. While attention has long focused on the activation of type 1 and type 2 helper T cells of the adaptive immune system in these diseases, it is becoming increasingly apparent that there is… Continue reading Mucosal inflammation at the respiratory interface: a zebrafish model
Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice
Recent data indicate a role for airway epithelial necroptosis, a regulated form of necrosis, and the associated release of damage associated molecular patterns (DAMPs) in the development of COPD. DAMPs can activate pattern recognition receptors (PRRs), triggering innate immune responses. We hypothesized that cigarette smoke (CS)-induced epithelial necroptosis and DAMP release initiate airway inflammation in… Continue reading Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice
Mediators between education and dental pain: a cross-sectional study to assess the role of dental services utilization
This study tested whether the pattern of dental services utilization and the reason for the last dental visit mediate the association between educational attainment and dental pain. This is a cross-sectional analysis ( *n* = 1099) based on data from a prospective cohort study in adults, southern Brazil. The mediating effects were assessed by including interaction terms in logistic regression models and by the KHB method, which estimated the direct, mediated, and total effects of education on dental pain. The prevalence of dental pain was 17.5%. Individuals with less than 12 yr of ... περισσότερα »
Systematic review of the in vitro effects of statins on oral and perioral microorganisms
Statins are medications administered orally and are widely used for lowering the blood cholesterol level. The aim of this study was to investigate the effects of orally administered statins on microorganisms infecting oral and perioral tissues. We performed a systematic review of published studies of the in vitro antimicrobial effects of statins on bacteria, viruses, and fungi, and searched PubMed, Web of Science, Cochrane Central, and Google scholar. Studies show that most statins exhibit antimicrobial effects against various oral microorganisms. Simvastatin is most effective ag... περισσότερα »
Molecular Pathways: Mechanism of Action for Talimogene Laherparepvec, a New Oncolytic Virus Immunotherapy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Oncolytic viruses are native or engineered viruses that preferentially replicate in and lyse cancer cells. Selective tumor cell replication is thought to depend on infection of neoplastic cells, which harbor low levels of protein kinase R (PKR) and dysfunctional type 1 interferon signaling elements. These changes allow more efficient viral replication, and with selected deletion […]
Combined antitumor therapy with metronomic topotecan and hypoxia-activated prodrug, evofosfamide, in neuroblastoma and rhabdomyosarcoma preclinical models
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Purpose: Tumor cells residing in tumor hypoxic zones are a major cause of drug resistance and tumor relapse. In this study, we investigated the efficacy of evofosfamide, a hypoxia-activated prodrug, and its combination with topotecan in neuroblastoma (NBL) and rhabdomyosarcoma (RMS) preclinical models. Experimental Design: NBL and RMS cells were tested in vitro to assess […]
Systemic immune activity predicts overall survival in treatment naive patients with metastatic pancreatic cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Background & Aims: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a 5-year survival rate <7% and is ultimately refractory to most treatments. To date, an assessment of immunologic factors relevant to disease has not been comprehensively performed for treatment naïve patients. We hypothesized that systemic immunologic biomarkers could predict overall survival (OS) in […]
Treatment Outcomes and Risk Factors for Recurrence after Definitive Surgery of Locally Invasive Well-Differentiated Papillary Thyroid Carcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YQ3KoO via IFTTT
Metformin Attenuates 131I-Induced Decrease in Peripheral Blood Cells in Patients with Differentiated Thyroid Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1JKOXiV via IFTTT
Therapeutic targeting of autophagy in neurodegenerative and infectious diseases
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
The Journal of Experimental Medicine from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1P1jJ8T via IFTTT
