Combined BRAF and MEK inhibition with stereotactic radiosurgery for BRAF mutant melanoma brain metastases.
Initial experience with combined BRAF and MEK inhibition with stereotactic radiosurgery for BRAF mutant melanoma brain metastases.: The combined use of the BRAF inhibitor dabrafenib and MEK inhibitor trametinib has been found to improve survival over dabrafenib alone. The management of melanoma brain metastases continues to present challenges. In this study, we report our initial experience in the management of melanoma brain metastases with stereotactic radiosurgery (SRS) with the use of BRAF and MEK inhibitors. We identified six patients treated with SRS for 17 brain metastases wit...περισσότερα »
The MECP2 variant c.925C>T (p.Arg309Trp) causes intellectual disability in both males and females without classic features of Rett syndrome
Abstract Missense *MECP2* variants can have various phenotypic effects ranging from a normal phenotype to typical Rett syndrome (RTT). In females the phenotype can also be influenced by the X-inactivation pattern. In this study we present detailed clinical descriptions of six patients with a rare base-pair substitution affecting Arg309 at the C-terminal end of the transcriptional repression domain (TRD). All patients have intellectual disability and present with some RTT features, but they do not fulfill the clinical criteria for typical or atypical RTT. Most of the patients also ... περισσότερα »
The Genetic Basis of Baculum Size and Shape Variation in Mice
The rapid divergence of male genitalia is a pre-eminent evolutionary pattern. This rapid divergence is especially striking in the baculum, a bone that occurs in the penis of many mammalian species. Closely related species often display diverse baculum morphology where no other morphological differences can be discerned. While this fundamental pattern of evolution has been appreciated at the level of gross morphology, nearly nothing is known of the genetic basis of size and shape divergence. Quantifying the genetic basis of baculum size and shape variation has been difficult becaus... περισσότερα »
Transcriptomic Analysis Identifies Candidate Genes and Gene Sets Controlling the Response of Porcine Peripheral Blood Mononuclear Cells to Poly I:C Stimulation
Polyinosinic-polycytidylic acid (poly I:C), an synthetic dsRNA analog, has been demonstrated to have stimulatory effects similar to viral dsRNA. To gain deep knowledge of the host transcriptional response of pigs to poly I:C stimulation, in the present study, we cultured and stimulated peripheral blood mononuclear cells (PBMC) of piglets of one Chinese indigenous breed (Dapulian) and one modern commercial breed (Landrace) with poly I:C, and comparatively analyzed their transcriptional profiling using RNA-sequencing (RNA-seq). Our results indicated that poly I:C stimulation can eli...περισσότερα »
Chicken gga-miR-103-3p Targets CCNE1 and TFDP2 and Inhibits MDCC-MSB1 Cell Migration
Marek's disease (MD) is a highly contagious viral neoplastic disease caused by Marek's disease virus (MDV), which could lead to a huge economic loss in poultry industry. Recently, microRNAs (miRNAs) were found in various cancers and tumors. In chickens, 994 mature miRNAs were identified through deep sequencing in recent years, but only a few miRNAs were further investigated about their functions. Previously, gga-miR-103-3p was found down-regulated in MDV-infected samples by using Solexa deep sequencing. In this study, we further verified the expression of gga-miR-103-3p among MDV-... περισσότερα »
Randomized Trial of Labor Induction in Women 35 Years of Age or Older
The average age of women at childbirth in industrialized nations has been increasing steadily for approximately 30 years. Between 1996 and 2006, births to women 35 years of age or older in the United Kingdom increased from 12% to 20% of all births. In 2006, a total of 5.6% of live births in the… from #Medicine via ola Kala on Inoreader http://ift.tt/1poAtld via IFTTT
Changes in knee kinematics following total knee arthroplasty
Total knee arthroplasty (TKA) changes the knee joint in both intentional and unintentional, known and unknown, ways. Patellofemoral and tibiofemoral kinematics play an important role in postoperative pain, function, satisfaction and revision, yet are largely unknown. Preoperative kinematics, postoperative kinematics or changes in kinematics may help identify causes of poor clinical outcome. Patellofemoral kinematics are challenging to record since the patella is obscured by the metal femoral component in X-ray and moves under the skin. The purpose of this study was to determine th... περισσότερα »
Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy in TYpe 2 diabetic patients with normoalbuminuria (PRIORITY): essential study design and rationale of a randomised clinical multicentre trial
Introduction Diabetes mellitus affects 9% of the European population and accounts for 15% of healthcare expenditure, in particular, due to excess costs related to complications. Clinical trials aiming for earlier prevention of diabetic nephropathy by renin angiotensin system blocking treatment in normoalbumuric patients have given mixed results. This might reflect that the large fraction of normoalbuminuric patients are not at risk of progression, thereby reducing power in previous studies. A specific risk classifier based on urinary proteomics (chronic kidney disease (CKD)273) ... περισσότερα »
Lay support for pregnant women with social risk: a randomised controlled trial
Objectives We sought evidence of effectiveness of lay support to improve maternal and child outcomes in disadvantaged families. Design Prospective, pragmatic, individually randomised controlled trial. Setting 3 Maternity Trusts in West Midlands, UK. Participants Following routine midwife systematic assessment of social risk factors, 1324 nulliparous women were assigned, using telephone randomisation, to standard maternity care, or addition of referral to a Pregnancy Outreach Worker (POW) service. Those under 16 years and teenagers recruited to the Family Nurse Partnership tri... περισσότερα »
Getting our house in order: an audit of the registration and publication of clinical trials supported by the National Institute for Health Research Oxford Biomedical Research Centre and the Musculoskeletal Biomedical Research Unit
Objectives To audit the proportion of clinical trials that had been publically registered and, of the completed trials, the proportion published. Setting 2 major research institutions supported by the National Institute of Health Research (NIHR). Primary and secondary outcome measures The proportion of trials reporting results within 12 months, 24 months and 'ever'. Factors associated with non-publication were analysed using logistic regression. Inclusion criteria Phases 2–4 clinical trials identified from internal documents and publication lists. Results In total, 286 tria... περισσότερα »
Reduced incidence of skin cancer in patients with alopecia areata
: A retrospective cohort study via ScienceDirect Publication: Cancer Epidemiology (open access) Publication date: April 2016 *Source:*Cancer Epidemiology, Volume 41 Author(s): Arash Mostaghimi, Sarah Qureshi, Cara Joyce, Ye Guo, Kathie P. Huang The risk of skin cancer in patients with alopecia areata (AA) is unknown. While the risk of skin cancer in chronic inflammatory alopecias may be elevated, AA shares many characteristics with vitiligo, an autoimmune illness associated with decreased risk of melanoma and non-melanoma skin cancers. In this retrospective cohort study, we determined ...περισσότερα »
ReCAP: Cancer Screening Patterns and Concerns in Caregivers of Patients Undergoing Radiation Therapy [Care Delivery]
ReCAP: Cancer Screening Patterns and Concerns in Caregivers of Patients Undergoing Radiation Therapy [Care Delivery]: QUESTION ASKED: What is the compliance with recommended cancer screening in caregivers who accompany patients to radiation oncology consultations, and are there specific barriers and deficiencies? SUMMARY ANSWER: The results revealed that younger participants (≤ 49 years) were less likely to report PCP discussion of cancer screening than older participants, and nearly half of the participants had one or more concerns regarding cancer screening (Fig 2B). Notable decr... περισσότερα »
Inhibition of Akt Potentiates Rapamycin Skin Chemoprevention
Inhibition of Akt Potentiates Rapamycin Skin Chemoprevention: The PI3Kinase/Akt/mTOR pathway has important roles in cancer development for multiple tumor types, including UV-induced nonmelanoma skin cancer. Immunosuppressed populations are at increased risk of aggressive cutaneous squamous cell carcinoma (SCC). Individuals who are treated with rapamycin (sirolimus, a classical mTOR inhibitor) have significantly decreased rates of developing new cutaneous SCCs compared with those that receive traditional immunosuppression. However, systemic rapamycin use can lead to significant adve... περισσότερα »
Magnesium as a diagnostic marker of cancer
Magnesium as a diagnostic marker of cancer: Magnesium as a diagnostic marker of cancer W Marciniak, M Muszyńska… - Hereditary cancer in …, 2015 - ncbi.nlm.nih.gov Magnesium plays a key role in many essential cellular processes. It is recognized that magnesium deficiency may lead to many disorders like cardiovascular disease, diabetes mellitus, hypertension, myocardial infarction or even cancer. Connection between ... Όλες οι 4 εκδοχές Παράθεση Αποθήκευση
Folate and Inflammatory Markers Moderate the Association Between Helicobacter pylori Exposure and Cognitive Function in US Adults
Abstract Background *Helicobacter pylori* (*H. pylori*) infection is associated with cognitive deficits in humans, an association potentially mediated or moderated by folate concentration or inflammation. Materials and Methods We used the National Health and Nutrition Examination Survey (NHANES) datasets to examine whether folate concentration or inflammation mediates or moderates the relationship between *H. pylori* and cognitive function. Models were performed using linear, Poisson, and zero-inflated Poisson regression, and we performed separate analyses for groups aged 20–59 a...περισσότερα »
The Use of a Brochure to Enable CAM-with-Chemotherapy Patient Education
The Use of a Brochure to Enable CAM-with-Chemotherapy Patient Education: AbstractThe majority of cancer patients receiving chemotherapy will consider taking complementary and alternative medicine (CAM) during their treatment. As biologically-active CAM may detrimentally interfere with chemotherapy treatment, cancer patients require evidence-based information on chemotherapy-CAM integration consequences. This study aimed to assess if the availability of a purpose-designed brochure within a cancer service aided doctors’ discussions with their patients on CAM use and helped patients u... περισσότερα »
Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti-inflammatory medication Research
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
With this study we investigated the role of nonsteroidal anti-inflammatory drugs (NSAIDs) in human skeletal muscle regeneration. Young men ingested NSAID [1200 mg/d ibuprofen (IBU)] or placebo (PLA) daily for 2 wk before and 4 wk after an electrical stimulation–induced injury to the leg extensor muscles of one leg. Muscle biopsies were collected from the […]
CD13/aminopeptidase N is a negative regulator of mast cell activation Research
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Antigen-induced mast cell (MC) activation via cross-linking of IgE-bound high-affinity receptors for IgE (FcRI) underlies type I allergy and anaphylactic shock. Comprehensive knowledge of FcRI regulation is thus required. We have identified a functional interaction between FcRI and CD13 in murine MCs. Antigen-triggered activation of IgE-loaded FcRI results in cocapping and cointernalization of CD13 and […]
Effectiveness of preventive and treatment interventions for primary headaches in the workplace: A systematic review of the literature
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Aim The purpose of this systematic literature review is to assess the benefits of workplace-based occupational therapies and interventions, including acute and preventive medication, on headache intensity and frequency, related disability as well as work-related outcomes. Methods A search of the literature was conducted in PubMed, MEDLINE, Cochrane library, CINAHL and Embase using terms related […]
Cyclophilin-B modulates collagen cross-linking by differentially affecting lysine hydroxylation in the helical and telopeptidyl domains of tendon type I collagen Molecular Bases of Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Covalent intermolecular cross-linking provides collagen fibrils with stability. The cross-linking chemistry is tissue-specific determined primarily by the state of lysine hydroxylation at the specific sites. A recent study on cyclophilin B (CypB) null mice, a model of recessive osteogenesis imperfecta, demonstrated that lysine hydroxylation at the helical cross-linking site of bone type I collagen was […]
The Klebsiella pneumoniae O12 ATP-binding cassette (ABC) transporter recognizes the terminal residue of its O-antigen polysaccharide substrate Microbiology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Export of the E. coli serotype O9a O-antigenic polysaccharide (O-PS) involves an ABC transporter. The process requires a non-reducing terminal residue, which is recognized by a carbohydrate-binding module (CBM) appended to the C-terminus of the nucleotide-binding domain of the transporter. Here, we investigate the process in Klebsiella pneumoniae serotype O12 (and Raoultella terrigena ATCC33257). The […]
Tubulin Dimer Reversible Dissociation: Affinity, Kinetics and Demonstration of a Stable Monomer Molecular Biophysics
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Tubulins are evolutionarily conserved proteins that reversibly polymerize and direct intracellular traffic. Of the tubulin family only αβ-tubulin forms stable dimers. We investigated the monomer-dimer equilibrium of rat brain αβ-tubulin using analytical ultracentrifugation and fluorescence anisotropy, observing tubulin in virtually fully monomeric and dimeric states. Monomeric tubulin was stable for a few hours and exchanged […]
Gemcitabine-Induced Subacute Cutaneous Lupus Erythematosus: A Case Report
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
We present a 63-year-old female with recurrent epithelial ovarian cancer who developed SCLE after administration of gemcitabine. Following discontinuation of gemcitabine and after oral steroid treatment, all skin lesions disappeared. In view of the extensive use of gemcitabine in recurrent ovarian cancer, it is important to be aware of the possibility of SCLE occurrence in […]
Second-Line Intraperitoneal Chemotherapy for Recurrent Epithelial Ovarian, Tubal and Peritoneal Cancer: A Propensity Score-Matching Study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Conclusions: Second-line IP chemotherapy confers longer progression-free survival than IV chemotherapy. Large-scale clinical trials should be conducted to validate the true efficacy.Chemotherapy 2015–16;61:240–248 (Source: Chemotherapy) from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Rr8sjp via IFTTT
Basilea launching antifungal CRESEMBA® (isavuconazole) in the United Kingdom – Nasdaq
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Basilea launching antifungal CRESEMBA® (isavuconazole) in the United Kingdom Nasdaq … such as patients with cancer and after transplantation. Invasive aspergillosis is all too often fatal. Mucormycosis (also known as zygomycosis) is a rapidly progressive and life-threatening invasive fungal infection, often affecting the nose and … from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OSlLHC via […]
Vikalpa
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Vikalpa, published by SAGE Publications, last updated on 2016-03-02, available at http://vik.sagepub.com from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://vik.sagepub.com/ via IFTTT
Nuclear accumulation of yes-associated protein (YAP) maintains the survival of doxorubicin-induced senescent cells by promoting survivin expression
• A low dose of doxorubicin (DOX) could induce senescence in HeLa cells• YAP is activated and accumulates in the nucleus in DOX-induced senescent cells• YAP knockdown led to apoptosis and not senescence• YAP-induced survivin expression contributes to the survival of senescent cells• Targeting YAP or survivin could eliminate drug-induced senescent tumor cells (Source: Cancer… Continue reading Nuclear accumulation of yes-associated protein (YAP) maintains the survival of doxorubicin-induced senescent cells by promoting survivin expression
Clinical significance of AGE-RAGE axis in colorectal cancer: associations with glyoxalase-I, adiponectin receptor expression and prognosis
Advanced glycation end products (AGEs) and their receptor RAGE emerge as important pathogenic contributors in colorectal carcinogenesis. However, their relationship to the detoxification enzyme Glyoxalase (GLO… (Source: BMC Cancer) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/21IXb5p via IFTTT
Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer – molecularly distinct behavior of cathepsin K in breast cancer
Breast cancer comprises clinically and molecularly distinct tumor subgroups that differ in cell histology and biology and show divergent clinical phenotypes that impede phase III trials, such as those utilizin… (Source: BMC Cancer) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TU4dBy via IFTTT
Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression
Novel therapies are needed for children with high-risk and relapsed neuroblastoma. We hypothesized that MAPK/ERK kinase (MEK) inhibition with the novel MEK1/2 inhibitor binimetinib would be effective in neurob… (Source: BMC Cancer) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/21IXb5d via IFTTT
POU5F1/Oct-4 expression in breast cancer tissue is significantly associated with non-sentinel lymph node metastasis
At present, few studies have explored the significance of POU5F1 (also known as octamer-bingding factor, Oct-4 or Oct-3) expression in breast cancer tissues. (Source: BMC Cancer) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/21IWDMV via IFTTT
Isolated Limb Infusion for Melanoma
Australian Multicenter Study of Isolated Limb Infusion for Melanoma: Abstract PurposeIsolated limb infusion (ILI) offers a less invasive alternative to isolated limb perfusion (ILP) for the treatment of locally advanced extremity melanoma. In Australia, ILI has essentially completely replaced ILP. The aim of this study was to collect and evaluate the results of ILI in an Australian multicenter setting. Patients and MethodsThe results of 316 first ILI procedures, performed between 1992 and 2008 in five Australian institutions, were collectively analyzed, with all five institutio... περισσότερα »
Local delivery of CpG-B and GM-CSF induces concerted activation of effector and regulatory T cells in the human melanoma sentinel lymph node
Local delivery of CpG-B and GM-CSF induces concerted activation of effector and regulatory T cells in the human melanoma sentinel lymph node: AbstractImpaired immune effector functions in the melanoma sentinel lymph node (SLN) may allow for early metastatic events. In an effort to determine the optimal way to strengthen immune defenses, 28 clinical stage I–II melanoma patients were randomized in a 3-arm Phase II study to receive, prior to excision and sampling of the SLN, i.d. injections of saline or low-dose CpG-B (CpG), alone or combined with GM-CSF (GM), around the melanoma exci...περισσότερα »
Molecular pathology in real time
Molecular pathology in real time: AbstractWith the development of sophisticated individualized therapeutic approaches, the role of pathology in classification of tumors is enormously increasing. The solely morphological characterization of neoplastic process is no more sufficient for qualified decision on optimal therapeutic approach. Thus, morphologic diagnosis must be supplemented by molecular analysis of the lesion with emphasis on the detection of status of certain markers used as predictive factors for targeted therapy. Both intrinsic and acquired types of intratumor heterogen... περισσότερα »
Genetic traits for hematogeneous tumor cell dissemination in cancer patients
Genetic traits for hematogeneous tumor cell dissemination in cancer patients: AbstractMetastatic relapse in patients with solid tumors is the consequence of cancer cells that disseminated to distant sites, adapted to the new microenvironment, and escaped systemic adjuvant therapy. There is increasing evidence that hematogeneous dissemination starts at an early stage of cancer progression with single tumor cells or cell clusters leaving the primary site and entering the blood circulation. These circulating tumor cells (CTCs) can extravasate into secondary tissues where they become ...περισσότερα »
Exome sequencing of oral squamous cell carcinoma
Exome sequencing of oral squamous cell carcinoma in users of Arabian snuff reveals novel candidates for driver genes: Abstract The study sought to identify genetic aberrations driving oral squamous cell carcinoma (OSCC) development among users of shammah, an Arabian preparation of smokeless tobacco. Twenty archival OSCC samples, 15 of which with a history of shammah exposure, were whole-exome sequenced at an average depth of 127x. Somatic mutations were identified using a novel, matched controls-independent filtration algorithm. CODEX and Exomedepth coupled with a novel, Database o... περισσότερα »
Tumour angiogenesis - origin of blood vessels
Tumour angiogenesis - origin of blood vessels: Abstract The conventional view of tumour vascularization is that tumours acquire their blood supply from neighbouring normal stroma. Additional methods of tumour vascularization such as intussusceptive angiogenesis, vasculogenic mimicry, vessel co-option, and vasculogenesis have been demonstrated to occur. However, the origin of the endothelial cells and pericytes in the tumour vasculature is not fully understood. Their origin from malignant cells has been shown indirectly in lymphoma and neuroblastoma by immuno-FISH experiments. It is...περισσότερα »
Identification of a predictive factor for distant metastasis in esophageal squamous cell carcinoma after definitive chemoradiotherapy
Identification of a predictive factor for distant metastasis in esophageal squamous cell carcinoma after definitive chemoradiotherapy: Abstract Background and purposeDistant metastasis (DM) after definitive chemoradiotherapy has not been a focus of research in esophageal carcinoma. At present, local–regional control is improving following advances in salvage treatments after definitive chemoradiotherapy. There is a need to focus on suppressing the development of DM. The aim of this study was to identify pre-treatment factors associated with DM after definitive chemoradiotherapy.... περισσότερα »
Cardioprotection and Safety of Dexrazoxane
Cardioprotection and Safety of Dexrazoxane in Patients Treated for Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Advanced-Stage Lymphoblastic Non-Hodgkin Lymphoma: A Report of the Childrens Oncology Group Randomized Trial Pediatric Oncology Group 9404 [Pediatric Oncology]: Purpose To determine the oncologic efficacy, cardioprotective effectiveness, and safety of dexrazoxane added to chemotherapy that included a cumulative doxorubicin dose of 360 mg/m2 to treat children and adolescents with newly diagnosed T-cell acute lymphoblastic leukemia (T-ALL) or lymphoblastic non-Hod... περισσότερα »
Palbociclib: efficacious but predictive biomarkers still needed
[Comment] Palbociclib: efficacious but predictive biomarkers still needed: Several therapeutic options are available for management of premenopausal patients with metastatic hormone-receptor-positive breast cancer, including single-agent endocrine therapy or combination regimens. Single agent treatment with an aromatase inhibitor or tamoxifen has resulted in major improvements in the adjuvant setting but has shown little clinical benefit in metastatic disease.1,2 Endocrine therapy is the standard of care for hormone-receptor-positive luminal, HER2-negative metastatic breast cancer.
Metformin for cancer prevention
[Comment] Metformin for cancer prevention: a reason for optimism: [image: fx1.sml] Obesity and its metabolic complications, including diabetes, have been associated with an increased risk of several cancers.1 The global obesity epidemic has fuelled a sustained rise in obesity-related cancers, especially in resource-poor regions with few options for population-based screening. Thus, the potential use of metformin as a novel cancer prevention strategy has generated much excitement in view of its low cost, favourable safety profile, and its potential for biological specificity in ... περισσότερα »
CEP-9722 (a PARP-1 and PARP-2 inhibitor) in combination with gemcitabine and cisplatin in patients with advanced solid tumors
An open-label, dose-escalation study to evaluate the safety and pharmacokinetics of CEP-9722 (a PARP-1 and PARP-2 inhibitor) in combination with gemcitabine and cisplatin in patients with advanced solid tumors: [image: image]Poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors may potentiate chemotherapy by hindering DNA damage repair pathways. CEP-9722 is the prodrug of CEP-8983, a selective inhibitor of PARP-1 and PARP-2. Preclinical studies and a prior phase 1 study suggested that CEP-9722 may cause less myelosuppression than has been observed with other oral PARP inhibitors. The p... περισσότερα »
Simotinib as a modulator of P-glycoprotein: substrate, inhibitor, or inducer?
Simotinib as a modulator of P-glycoprotein: substrate, inhibitor, or inducer?: [image: image]As a new antitumor drug, simotinib hydrochloride is prescribed for prolonged periods, often to patients with comorbidities. Therefore, the risk for developing drug resistance and drug–drug interactions between simotinib and other agents has to be taken into consideration. As P-glycoprotein (P-gp) is an efflux transporter, which plays a significant role in drug resistance and influences the pharmacological properties and toxicities of the drugs it interacts with, the interactions between simo...περισσότερα »
Spontaneous regression of tumour and the role of microbial infection – possibilities for cancer treatment
Spontaneous regression of tumour and the role of microbial infection – possibilities for cancer treatment: [image: image]This review deals with the role of microorganisms in spontaneous regression of a tumour. Spontaneous cancer regression is a phenomenon that has been described for many centuries. One of the most well known methods of inducing spontaneous regression of cancer is the application of Coley’s toxin (heat-killed Streptococcus pyogenes and Serratia marcescens), which has been used for the successful treatment of sarcomas, carcinomas, lymphomas, myelomas and melanomas. In...περισσότερα »
Efficacy and safety of vinorelbine in heavily pretreated recurrent/metastatic head and neck squamous cell carcinoma patients
Efficacy and safety of vinorelbine in heavily pretreated recurrent/metastatic head and neck squamous cell carcinoma patients: [image: image] The aim of this study was to evaluate the efficacy and tolerance of vinorelbine as a single agent in the treatment of recurrent/metastatic head and neck squamous cell carcinoma. Patients were treated with oral or intravenous vinorelbine according to the pluridisciplinary tumor board’s decision. Efficacy and safety outcomes were analyzed retrospectively. Twenty-three patients were included in the study. Sixteen patients (69%) had received at le...περισσότερα »
Tumor growth kinetics in medullary thyroid cancer patients receiving cabozantinib
Population pharmacokinetic/pharmacodynamic modeling of tumor growth kinetics in medullary thyroid cancer patients receiving cabozantinib: [image: image]Nonlinear mixed effects models were developed to describe the relationship between cabozantinib exposure and target lesion tumor size in a phase III study of patients with progressive metastatic medullary thyroid cancer. These models used cabozantinib exposure estimates from a previously published population pharmacokinetic model for cabozantinib in cancer patients that was updated with data from healthy-volunteer studies. Semi-mecha... περισσότερα »
Genome Sequencing of Multiple Primary Tumors Reveals a Novel PALB2 Variant [DIAGNOSIS IN ONCOLOGY]
*Genome Sequencing of Multiple Primary Tumors Reveals a Novel PALB2 Variant [DIAGNOSIS IN ONCOLOGY]: * *[image: graphic-1.small.gif]* *1. Kasmintan A. Schrader, 2. Kelly L. Stratton and 3. Rajmohan Murali* 1. *Memorial Sloan Kettering Cancer Center, New York, NY* 1. *Yael Laitman* 1. *Chaim Sheba Medical Center, Tel-Hashomer, and Tel Aviv University, Tel-Aviv, Israel* 1. *Luca Cavallone* 1. *Lady Davis Institute, Jewish General Hospital, Montreal, Québec, Canada* *1. Lily Offit, 2. Yong Hannah Wen, 3. Tinu Thomas, 4. Sohela Shah, 5. Roh... περισσότερα »
CELF4 Variant and Anthracycline-Related Cardiomyopathy
CELF4 Variant and Anthracycline-Related Cardiomyopathy: A Childrens Oncology Group Genome-Wide Association Study [Pediatric Oncology]: Purpose Interindividual variability in the dose-dependent association between anthracyclines and cardiomyopathy suggests that genetic susceptibility could play a role. The current study uses an agnostic approach to identify genetic variants that could modify cardiomyopathy risk. Methods A genome-wide association study was conducted in childhood cancer survivors with and without cardiomyopathy (cases and controls, respectively). Single-nucleotide pol...περισσότερα »
BRAF V600-Mutant Metastatic Melanoma Receiving Dabrafenib Combined With Trametinib [Melanoma]
Overall Survival and Durable Responses in Patients With BRAF V600-Mutant Metastatic Melanoma Receiving Dabrafenib Combined With Trametinib [Melanoma]: Purpose To report the overall survival (OS) and clinical characteristics of BRAF inhibitor–naive long-term responders and survivors treated with dabrafenib plus trametinib in a phase I and II study of patients with *BRAF* V600 mutation–positive metastatic melanoma. Methods BRAF inhibitor–naive patients treated with dabrafenib 150 mg twice daily plus trametinib 2 mg daily (the 150/2 group) from the non–randomly assigned (part B) and ...περισσότερα »
The Impact of a Prophylactic Skin Treatment Regimen on Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-Induced Skin Toxicities
Pan Canadian Rash Trial: A Randomized Phase III Trial Evaluating the Impact of a Prophylactic Skin Treatment Regimen on Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-Induced Skin Toxicities in Patients With Metastatic Lung Cancer [Treatment-Related Complications]: Purpose Erlotinib is an epidermal growth factor receptor inhibitor approved for patients with advanced non–small-cell lung cancer (NSCLC) whose epidermal growth factor receptor expression status is positive or unknown. Although it is efficacious, erlotinib can cause skin toxicity. This prospective, randomized ...περισσότερα »
Extensive Squamous Cell Carcinoma of the Skin Related to Use of Sorafenib for Treatment of FLT3-Mutant Acute Myeloid Leukemia [DIAGNOSIS IN ONCOLOGY]
*Extensive Squamous Cell Carcinoma of the Skin Related to Use of Sorafenib for Treatment of FLT3-Mutant Acute Myeloid Leukemia [DIAGNOSIS IN ONCOLOGY]: * *[image: F1.small.gif]* *1. Amir T. Fathi⇑, 2. William M. Lin, 3. Tyler Durazzo, 4. Adriano Piris,5. Hossein Sadrzadeh, 6. Lindsay Bernardo, 7. Darrel R. Borger, 8. Steven L. McAfee,9. Daniela Kroshinsky and 10. Yi-Bin Chen* *+**Author Affiliations* 1. *Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA* 1. *Corresponding author: Amir T. Fathi, MD, Massachusetts General ... περισσότερα »
Benzene exposure and risk of non-Hodgkin lymphoma
Resolving uncertainty in the spatial relationships between passive benzene exposure and risk of non-Hodgkin lymphoma via ScienceDirect Publication: Cancer Epidemiology (open access) Publication date: Available online 2 March 2016 *Source:*Cancer Epidemiology Author(s): Jeffrey M. Switchenko, Catherine Bulka, Kevin Ward, Jean L. Koff, A. Rana Bayakly, P. Barry Ryan, Lance A. Waller, Christopher R. Flowers BackgroundBenzene is a known occupational carcinogen associated with increased risk of hematologic cancers, but the relationships between quantity of passive benzene exposure through r... περισσότερα »
MDM2 inhibition in adenoid cystic carcinoma
MDM2 inhibition in adenoid cystic carcinoma: Purpose: There are no effective treatment options for patients with advanced adenoid cystic carcinoma (ACC). Here, we evaluated the effect of a new small molecule inhibitor of the MDM2-p53 interaction (MI-773) in preclinical models of ACC. Experimental Design: To evaluate the anti-tumor effect of MI-773, we administered it to mice harboring 3 different patient-derived xenograft (PDX) models of ACC expressing functional p53. The effect of MI-773 on MDM2, p53, phospho-p53 and p21 was examined by Western blots in 5 low passage primary human...περισσότερα »
FGFR1 in head and neck squamous cell carcinoma
FGFR1 in head and neck squamous cell carcinoma: Purpose:FGFR1 (fibroblast growth factor receptor 1) is a promising therapeutic target in multiple tumors, including head and neck squamous cell carcinoma (HNSCC). However, resistance remains a major setback. In this study we have investigated the prognostic value of FGFR1 expression in HNSCC, the therapeutic relevance of targeting FGFR with AZD4547, and potential resistant mechanisms. Experimental Design:Immunohistochemistry and fluorescence in situ hybridization were applied on tissue microarrays to investigate FGFR1 protein expressi... περισσότερα »
Sarcopenia as a predictor of pulmonary complications after esophagectomy for thoracic esophageal cancer
Sarcopenia as a predictor of pulmonary complications after esophagectomy for thoracic esophageal cancer: Background and Objectives Sarcopenia or loss of skeletal muscle mass has been identified as a poor prognostic factor for a wide variety of diseases and conditions. We investigated whether preoperative sarcopenia is associated with postoperative complications in patients undergoing esophagectomy for thoracic esophageal cancer. Methods We retrospectively reviewed the medical records of consecutive patients with thoracic esophageal cancer who underwent esophagectomy between Septemb...περισσότερα »
Sinuleptolide inhibits proliferation of oral cancer Ca9-22 cells
involving apoptosis, oxidative stress, and DNA damage via Oral Biology Publication date: Available online 2 March 2016 *Source:*Archives of Oral Biology Author(s): Yung-Ting Chang, Chiung-Yao Huang, Kun-Tzu Li, Ruei-Nian Li, Chih-Chuang Liaw, Shih-Hsiung Wu, Jing-Ru Liu, Jyh-Horng Sheu, Hsueh-Wei Chang ObjectiveSinuleptolide, a soft corals-derived bioactive norditerpenoid, is a marine natural product with a potent anti-inflammatory effect. We evaluate the potential anti-oral cancer effects of sinuleptolide and investigate the possible mechanisms involved.Designs: Cell viability, cell ...περισσότερα »
Periodontitis and Inflammatory Bowel Disease
Cytokine Expression in Gingival and Intestinal Tissues of Patients with Periodontitis and Inflammatory Bowel Disease: An Exploratory Study via Oral Biology Publication date: Available online 2 March 2016 *Source:*Archives of Oral Biology Author(s): Juliana Santos Bittencourt Menegat, Ronaldo Lira-Junior, Mariana Alves Siqueira, Fernanda Brito, Ana Teresa Carvalho, Ricardo Guimarães Fischer, Carlos Marcelo Figueredo Objectiveto evaluate the expression of the cytokines IFN-γ, IL-1β, IL-4, IL-6, IL-10, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, IL-17A, IL-17F, sCD40L, and TNF-α in gingival... περισσότερα »
TSCC : miR-22 regulates cell invasion, migration and proliferation
miR-22 regulates cell invasion, migration and proliferation in vitro through inhibiting CD147 expression in tongue squamous cell carcinoma via Oral Biology Publication date: June 2016 *Source:*Archives of Oral Biology, Volume 66 Author(s): Kaifeng Qiu, Zixian Huang, Zhiquan Huang, Zhichao He, Siping You ObjectivesTongue squamous cell carcinoma (TSCC) is the most common type of head and neck squamous cell carcinoma (HNSCC) in China, and its survival rate remains unsatisfactory. miR-22 has been identified as a tumor suppressor in many human cancers, and high expression of CD147 occurs in ... περισσότερα »
Olfactory event-related potentials: a new approach for the evaluation of olfaction in nasopharyngeal carcinoma patients treated with chemo-radiotherapy
Main ArticleOlfactory event-related potentials: a new approach for the evaluation of olfaction in nasopharyngeal carcinoma patients treated with chemo-radiotherapyB Gallettia1, R Santoroa1, V K Mannellaa1, F Caminitia2, L Bonannoa2, S De Salvoa2, G Cammarotoa1 c1 and F Gallettia1 a1 Department of Otorhinolaryngology, University of Messina, Messina, Italy a2 Department of Research, Istituto di Ricovero e Cura a Carattere Scientifico (‘IRCCS’) Centro Neurolesi ‘Bonino Pulejo’, Messina, Italy Abstract Objective: Olfactory dysfunction is a possible side effect of chemo-radiotherapy perform...περισσότερα »
The exacerbation of rhinitis medicamentosa (RM) induced by oxymetazoline (OMZ) or benzalkonium chloride (BKC)
Effects of benzalkonium chloride on histamine H1 receptor mRNA expression in nasal epithelial cells via Auris Nasus Larynx Publication date: Available online 2 March 2016 *Source:*Auris Nasus Larynx Author(s): Masaki Kawabata, Junichiro Ohori, Yuichi Kurono ObjectiveTo better understand the causes of the exacerbation of rhinitis medicamentosa (RM) induced by oxymetazoline (OMZ) or benzalkonium chloride (BKC), we examined the impact of pretreatment with OMZ or BKC on cultured human nasal epithelial cells. We also examined the effect of mometasone furoate (MF) on the cultured human nasa... περισσότερα »
Repeated Ventilation Tube Insertion
Variables Associated with Repeated Ventilation Tube Insertion in Healthy Non-Syndromic Children via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 2 March 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Han Zhang, Yaser Alrajhi, Hamdy El-Hakim ObjectivesThe objectives of this study was to determine variables associated with rVT insertions for rAOM and/or OME in otherwise healthy children.MethodsThis was designed as a retrospectively controlled cohort study. Patients were identified from a prospectively collected ... περισσότερα »
The homozygote p.V27I/p.E114G variant of GJB2 is a putative indicator of nonsyndromic hearing loss
in Chinese infants via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 2 March 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Xiao-lin Yang, Yue Huang, Wen-Xia Chen, Bo Duan, Ping Lu, Yan Wang, Zheng-min Xu The gap junction β2 (GJB2) gene is associated with more than half of the recessive forms of hereditary hearing loss (HHL). However, the correlation between p.V27I and p.E114G variants of GJB2 and hearing phenotype remains controversial. This study aimed to clarify possible roles of these variants in Chinese ...περισσότερα »
Prognostic impact of pathological response to neoadjuvant chemotherapy followed by definitive surgery in sinonasal squamous cell carcinoma
Prognostic impact of pathological response to neoadjuvant chemotherapy followed by definitive surgery in sinonasal squamous cell carcinoma: [image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background The significance of neoadjuvant chemotherapy followed by definitive surgery for sinonasal squamous cell carcinoma (SCC) was investigated using surgical specimens. Methods Surgery was performed in 58 patients, including 43 patients who had received neoadjuvant chemotherapy. The pathological response was classified as grades 0 (no effect), 1 (slight effect), 2 (moderate effec... περισσότερα »
Auswirkungen aktueller Trends in Gesellschaft, Medizin und Politik auf die Zukunft der HNO-Heilkunde
Auswirkungen aktueller Trends in Gesellschaft, Medizin und Politik auf die Zukunft der HNO-Heilkunde: Zusammenfassung HintergrundJedes medizinische Fachgebiet unterliegt einem permanenten Wandel, so auch die HNO-Heilkunde. Anhand der Analyse der Trends gesellschaftlicher Veränderungen, des medizinischen Fortschritts und politscher Konsequenzen wird versucht, die Auswirkungen auf die HNO-Heilkunde partiell zu antizipieren. TrendsDer demographische Wandel und medizinische Fortschritt führen zu einem gesteigerten medizinischen Bedarf. Hinzu kommen die sog. Feminisierung der Mediz... περισσότερα »
Das autologe Haut-Knorpel-Transplantat aus dem Cavum conchae zur Rekonstruktion mehrschichtiger nasaler Defekte
Das autologe Haut-Knorpel-Transplantat aus dem Cavum conchae zur Rekonstruktion mehrschichtiger nasaler Defekte: Zusammenfassung HintergrundAutologe Haut-Knorpel-Transplantate, sog. Composite grafts (CG), sind ein wichtiger Bestandteil der Rekonstruktion mehrschichtiger Defekte der Nase. Ein CG aus dem Cavum conchae muss sowohl funktionelle als auch ästhetische Ansprüche erfüllen. Ziel der ArbeitDieser Artikel beschreibt die Indikationen für CG und untersucht das Einheilungsverhalten sowie die funktionell-ästhetischen Ergebnisse. Es handelt sich um eine Übersichtsarbeit; die au... περισσότερα »
Assessment of VOR gain function and its test–retest reliability in normal hearing individuals
Assessment of VOR gain function and its test–retest reliability in normal hearing individuals: AbstractVideo head impulse test (vHIT) aids to assess all three pairs of semi-circular canals (SCCs) separately and can be utilized to find out the exact site of lesion in any three SCCs by measuring vestibulo ocular reflex (VOR) gain. VOR gain value of vHIT has been used to diagnose different vestibular pathologies. Hence, it is important to establish the test–retest reliability of the VOR gain parameters before it could be administered to the patients. Therefore, the aim of the present ... περισσότερα »
The functional outcome of blow-out fractures managed surgically and conservatively: our experience in 100 patients
The functional outcome of blow-out fractures managed surgically and conservatively: our experience in 100 patients: AbstractThe proportion of orbital blow-out fractures (BOFs) which are operated upon varies. The purpose of this study was to determine the treatment pattern of BOFs at our tertiary trauma centre and to evaluate the functional outcomes in patients according to whether they were managed surgically or conservatively. The study design is a retrospective cohort study and the setting is Tertiary care University Hospital. The participants include patients with isolated BOFs ... περισσότερα »
Otologic evaluation of patients with primary antibody deficiency
Otologic evaluation of patients with primary antibody deficiency: AbstractCommon variable immunodeficiency (CVID) represents the most frequent primary immunodeficiency, often encountered in the ENT clinical practice. The clinical spectrum of CVID is quite broad, but otitis media are certainly among the most common clinical manifestations. This prospective study enrolled 60 patients (34 males, 26 females) with a previous diagnosis of CVID with the aim of performing an otologic evaluation and a more precision characterization of incidence, diagnosis, and treatment of otitis media in ...περισσότερα »
Childhood Maltreatment and Headache Disorders
Childhood Maltreatment and Headache Disorders: AbstractChildhood maltreatment is substantiated in 12 % of children, but nearly 50 % adults recall having been neglected or abused as children. Maltreatment, especially emotional abuse, is associated with migraine. Dysregulation of the HPA axis, autonomic, immune, and metabolic systems appears to be a consequence of maltreatment, and is also reported in migraine. Areas of the brain structurally and functionally affected by childhood abuse and by migraine are also similar, and include the limbic system structures, which connect to pain ...περισσότερα »
Sialendoscopy as a management tool in patients with foreign body impaction of the salivary gland
Sialendoscopy as a management tool in patients with foreign body impaction of the salivary gland: [image: gr1.sml] It has been long known that sialendoscopy has both diagnostic and therapeutic benefits in the identification and treatment of sialadenitis. Sialendoscopy can also be used to triage patients with traumatic injury or foreign bodies lodged in the parotid gland. AbstractPurpose It has been long known that sialendoscopy has both diagnostic and therapeutic benefits in the identification and treatment of sialadenitis. Sialendoscopy can also be used to triage patients w... περισσότερα »
Concave shape in soft tissue free flaps in oral cavity reconstruction
From flat into concave shape in soft tissue free flaps in oral cavity reconstruction: The origami technique via ScienceDirect Publication: Oral Oncology Publication date: Available online 2 March 2016 *Source:*Oral Oncology Author(s): Chung-Kan Tsao, Joaquim Megias Barrera, Charles Yuen Yung Loh [image: Pre and post folding of the ALT flap for recreation of the buccal grooves at ...] [image: Pre (Left) and post (Right) origami de-epithelisation of triangles on a profunda ...]
Effects of aging on the response of single neurons to amplitude modulated noise in primary auditory cortex
of Rhesus macaque by Overton, J. A., Recanzone, G. H. via Journal of Neurophysiology Temporal envelope processing is critical for speech comprehension, which is known to be affected by normal aging. While the macaque is an excellent animal model for human cerebral cortical function, few studies have investigated neural processing in the auditory cortex of aged non-human primates. We therefore investigated age-related changes in the spiking activity of neurons in primary auditory cortex (A1) of two aged macaque monkeys using amplitude-modulated (AM) noise, and compared these responses... περισσότερα »
Gemcitabine-Induced Subacute Cutaneous Lupus Erythematosus: A Case Report
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
We present a 63-year-old female with recurrent epithelial ovarian cancer who developed SCLE after administration of gemcitabine. Following discontinuation of gemcitabine and after oral steroid treatment, all skin lesions disappeared. In view of the extensive use of gemcitabine in recurrent ovarian cancer, it is important to be aware of the possibility of SCLE occurrence in […]
Second-Line Intraperitoneal Chemotherapy for Recurrent Epithelial Ovarian, Tubal and Peritoneal Cancer: A Propensity Score-Matching Study
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Conclusions: Second-line IP chemotherapy confers longer progression-free survival than IV chemotherapy. Large-scale clinical trials should be conducted to validate the true efficacy.Chemotherapy 2015–16;61:240–248 (Source: Chemotherapy) from Chemotherapy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Rr8sjp via IFTTT
Lipopolysaccharide Structure and Biosynthesis in Helicobacter pylori
Abstract This review covers the current knowledge and gaps in *Helicobacter pylori* lipopolysaccharide (LPS) structure and biosynthesis. *H. pylori* is a Gram-negative bacterium which colonizes the luminal surface of the human gastric epithelium. Both a constitutive alteration of the lipid A preventing TLR4 elicitation and host mimicry of the Lewis antigen decorated O-antigen of *H. pylori* LPS promote immune escape and chronic infection. To date, the complete structure of *H. pylori* LPS is not available, and the proposed model is a linear arrangement composed of the inner core d... περισσότερα »
Cannabis Abuse Is Increasing and Associated with Increased Emergency Department Utilization in Gastroenterology Patients
Abstract Background The role of cannabinoids in gastrointestinal diseases is controversial and of great interest, yet their use in patients has not been critically examined. Aim To determine the prevalence and effects of cannabis abuse on healthcare utilization, as measured by emergency department (ED) visits, in a large, tertiary gastroenterology practice. Methods All patients seen in the gastroenterology clinic at a tertiary care center during a 27-year period (1986–2013) were included in our study to determine the overall prevalence of cannabis abuse. We matched cannabis abus... περισσότερα »
Feasibility of a 'reversed isolated forearm technique by regional antagonization of rocuronium-induced neuromuscular block: a pilot study
Background The isolated forearm technique is used to monitor intraoperative awareness. However, this technique cannot be applied to patients who must be kept deeply paralysed for >1h, because the tourniquet preventing the neuromuscular blocking agent from paralysing the forearm must be deflated from time to time. To overcome this problem, we tested the feasibility of a 'reversed' isolated forearm technique. Methods Patients received rocuronium 0.6 mg kg–1 i.v. to achieve muscle paralysis. A tourniquet was then inflated around one upper arm to prevent further blood supply to the...περισσότερα »
Comparison between thrombelastography and thromboelastometry in hyperfibrinolysis detection during adult liver transplantation
Background Hyperfibrinolysis is one of the main causes of non-surgical bleeding during liver transplantation (LT). Viscoelastic haemostatic assays, including thromboelastometry (ROTEM®) and thrombelastography (TEG®), can detect hyperfibrinolysis at the bedside. No study has yet demonstrated which device or assay is more suitable for detecting hyperfibrinolysis. Methods This prospective observational study compared ROTEM® and TEG® in isolated adult LT. ROTEM® (EXTEM® [tissue factor activation], FIBTEM® [tissue factor activation with platelet inhibition], and APTEM® [tissue factor... περισσότερα »
The Pig Olfactory Brain: A Primer
Despite the fact that pigs are reputed to have excellent olfactory abilities, few studies have examined regions of the pig brain involved in the sense of smell. The present study provides an overview of the olfactory bulb, anterior olfactory nucleus, and piriform cortex of adult pigs using several approaches. Nissl, myelin, and Golgi stains were used to produce a general overview of the organization of the regions and confocal microscopy was employed to examine 1) projection neurons, 2) GABAergic local circuit neurons that express somatostatin, parvalbumin, vasoactive intestinal p... περισσότερα »
Horses, hemiones, hydruntines? Assessing the reliability of dental criteria for assigning species to southwest Asian equid remains.
ABSTRACT Many faunal assemblages across southwest Asia contain the remains of multiple wild equid species, which may reflect individual prehistoric human populations' use of different hunting and/or landscape exploitation strategies. Accurate equid species assignments are therefore important. This paper tests the extent to which zooarchaeologists agree on equid species assignments made using commonly used zooarchaeological dental identification criteria. Seven zooarchaeologists individually use published criteria to assign species to equid teeth from Neolithic Çatalhöyük in centra...περισσότερα »
The Pig Olfactory Brain: A Primer
Despite the fact that pigs are reputed to have excellent olfactory abilities, few studies have examined regions of the pig brain involved in the sense of smell. The present study provides an overview of the olfactory bulb, anterior olfactory nucleus, and piriform cortex of adult pigs using several approaches. Nissl, myelin, and Golgi stains were used to produce a general overview of the organization of the regions and confocal microscopy was employed to examine 1) projection neurons, 2) GABAergic local circuit neurons that express somatostatin, parvalbumin, vasoactive intestinal p... περισσότερα »
The Effect of a Mechanical Arm System on Portable Grinder Vibration Emissions
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Mechanical arm systems are commonly used to support powered hand tools to alleviate ergonomic stressors related to the development of workplace musculoskeletal disorders. However, the use of these systems can increase exposure times to other potentially harmful agents such as hand-transmitted vibration. To examine how these tool support systems affect tool vibration, the primary objectives […]
Exposure to BTEX and Ethers in Petrol Station Attendants and Proposal of Biological Exposure Equivalents for Urinary Benzene and MTBE
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective: To assess exposure to benzene (BEN) and other aromatic compounds (toluene, ethylbenzene, m+p-xylene, o-xylene) (BTEX), methyl tert-butyl ether (MTBE), and ethyl tert-butyl ether (ETBE) in petrol station workers using air sampling and biological monitoring and to propose biological equivalents to occupational limit values. Methods: Eighty-nine petrol station workers and 90 control subjects were investigated. […]
Johann Herder, Early Nineteenth-century Romanticism, and the Common Roots of Multiculturalism and Right-wing … – Telos Press
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Telos Press Johann Herder, Early Nineteenth-century Romanticism, and the Common Roots of Multiculturalism and Right-wing … Telos Press Second, Herder claims that foreign cultures devour expressions of indigenous culture “like a cancer.” What do right-wing populists and multiculturalists say about this? Right-wing … While the multiculturalist goes out of his way to protect the … […]
Modern Family Writer: Trumps a Monster and a Pussy – Daily Beast
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Daily Beast Modern Family Writer: Trumps a Monster and a Pussy Daily Beast “I’m like a guy who you just told has cancer. I refuse to believe he will become president. Maybe I am just in a denial phase. I still believe a guy who has insulted this many Americans, of all shapes and sizes…cannot […]
Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy in TYpe 2 diabetic patients with normoalbuminuria (PRIORITY): essential study design and rationale of a randomised clinical multicentre trial
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Introduction Diabetes mellitus affects 9% of the European population and accounts for 15% of healthcare expenditure, in particular, due to excess costs related to complications. Clinical trials aiming for earlier prevention of diabetic nephropathy by renin angiotensin system blocking treatment in normoalbumuric patients have given mixed results. This might reflect that the large fraction of […]
Lay support for pregnant women with social risk: a randomised controlled trial
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives We sought evidence of effectiveness of lay support to improve maternal and child outcomes in disadvantaged families. Design Prospective, pragmatic, individually randomised controlled trial. Setting 3 Maternity Trusts in West Midlands, UK. Participants Following routine midwife systematic assessment of social risk factors, 1324 nulliparous women were assigned, using telephone randomisation, to standard maternity care, […]
Getting our house in order: an audit of the registration and publication of clinical trials supported by the National Institute for Health Research Oxford Biomedical Research Centre and the Musculoskeletal Biomedical Research Unit
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives To audit the proportion of clinical trials that had been publically registered and, of the completed trials, the proportion published. Setting 2 major research institutions supported by the National Institute of Health Research (NIHR). Primary and secondary outcome measures The proportion of trials reporting results within 12 months, 24 months and ‘ever’. Factors associated […]
Is the HAS-BLED score useful in predicting post-extraction bleeding in patients taking warfarin? A retrospective cohort study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective Unexpected post-extraction bleeding is often experienced in clinical practice. Therefore, determining the risk of post-extraction bleeding in patients receiving anticoagulant therapy prior to surgery is beneficial. This study aimed to verify whether the HAS-BLED score was useful in predicting post-extraction bleeding in patients taking warfarin. Design Retrospective cohort study. Setting Department of Oral and […]
Adaptation and validation of the Distress Scale for Mexican patients with type 2 diabetes and hypertension: a cross-sectional survey
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives The aim of this study was to adapt and validate the Distress Scale for Mexican patients with type 2 diabetes and hypertension (DSDH17M). Setting Two family medicine clinics affiliated with the Mexican Institute of Social Security. Participants 722 patients with type 2 diabetes and/or hypertension (235 patients with diabetes, 233 patients with hypertension and […]
Menstrual hygiene management among adolescent girls in India: a systematic review and meta-analysis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives To assess the status of menstrual hygiene management (MHM) among adolescent girls in India to determine unmet needs. Design Systematic review and meta-analysis. We searched PubMed, The Global Health Database, Google Scholar and references for studies published from 2000 to September 2015 on girls’ MHM. Setting India. Participants Adolescent girls. Outcome measures Information on […]
Myofascial techniques: what are their effects on joint range of motion and pain? - A systematic review and meta-analysis of randomised controlled trials
Publication date: Available online 2 March 2016 *Source:*Journal of Bodywork and Movement Therapies Author(s): Tamsyn R. Webb, Dévan Rajendran BackgroundThis systematic review aimed to determine the evidence for the effect of a single manually applied myofascial technique (MFT) on joint range of motion (JROM) and pain in non-pathological symptomatic subjects.MethodsAuthors independently searched the following databases: PEDro; Cochrane Library; NLM PubMed; EMBASE; Academic Search Premier; MEDLINE; Psychology and Behavioural Sciences Collection; PsycINFO; SPORTSDiscus; CINAHL Plus fr... περισσότερα »
Vertebral-Body Erosion in Thoracic Aortic Aneurysm
Figure 1. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1WW2ivx via IFTTT
Stroke and t-PA — Triggering New Paradigms of Care
[image: NEJM-Tab-clinical_newanim.gif] Stroke takes no prisoners. Every day, more than 14,000 people of all ages and ethnic backgrounds die from a stroke. According to the World Health Organization, stroke is the second leading cause of death among people over 60 years of age and the fifth leading cause among those 15 to 59 years of age.… from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1Rr0yXk via IFTTT
Optic Neuropathy due to Chronic Lymphocytic Leukemia Proven With Optic Nerve Sheath Biopsy and Chronic Myelogenous Leukemia Relapse Presenting With CNS Blast Crisis and Bilateral Optic Nerve Infiltration: Comment.
No abstract available from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1VRfdyL via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LzZB2g via IFTTT
Discovering untapped relationship potential with patients in telehealth: a qualitative interview study
Objectives To explore factors that influence relationship building between telehealth professionals and patients with chronic illness over a distance, from a telehealth professional’s perspective. Design 4 focus group interviews were conducted in June 2014. Digital recordings were transcribed verbatim and qualitative content analysis was performed using an iterative process of 3 coding rounds. Participants 20… Continue reading Discovering untapped relationship potential with patients in telehealth: a qualitative interview study
Thirteen-And-A-Half Syndrome.
We describe a 50-year-old man who developed eight-and-a-half syndrome associated with an ipsilateral trigeminal nerve palsy because of a post-transplant lymphoproliferative disorder. This case widens the spectrum of eight-and-a-half syndrome to include a thirteen-and-a-half syndrome. (C) 2016 by North American Neuro-Ophthalmology Society from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1UzGsiI via IFTTT from #Med Blogs… Continue reading Thirteen-And-A-Half Syndrome.
How do authors of systematic reviews deal with research malpractice and misconduct in original studies? A cross-sectional analysis of systematic reviews and survey of their authors
Objectives To study whether systematic reviewers apply procedures to counter-balance some common forms of research malpractice such as not publishing completed research, duplicate publications, or selective reporting of outcomes, and to see whether they identify and report misconduct. Design Cross-sectional analysis of systematic reviews and survey of their authors. Participants 118 systematic reviews published in… Continue reading How do authors of systematic reviews deal with research malpractice and misconduct in original studies? A cross-sectional analysis of systematic reviews ... περισσότερα »
{omega}-3 Fatty acids for major depressive disorder in adults: an abridged Cochrane review
Objective To assess the effects of n-3 polyunsaturated fatty acids (n-3PUFAs; also known as -3 fatty acids) compared with comparator for major depressive disorder (MDD) in adults. Design Systematic review and meta-analyses. Data sources The Cochrane Depression, Anxiety and Neurosis Review Group’s Specialised Registers (CCDANCTR) and International Trial Registries searched to May 2015. CINAHL searched… Continue reading {omega}-3 Fatty acids for major depressive disorder in adults: an abridged Cochrane review
Orbital Apex Syndrome Secondary to Herpes Zoster Ophthalmicus.
Orbital apex syndrome is a rare complication of herpes zoster ophthalmicus. In addition to our case, we review the clinical presentation, imaging findings, treatment options, and prognosis of 14 other reported cases. Magnetic resonance imaging of our patient demonstrated diffuse enhancement of the orbit involving the orbital apex, optic nerve and/or nerve sheath, extraocular muscles,… Continue reading Orbital Apex Syndrome Secondary to Herpes Zoster Ophthalmicus.
Socioeconomic deprivation and barriers to live-donor kidney transplantation: a qualitative study of deceased-donor kidney transplant recipients
Objectives Socioeconomically deprived individuals with renal disease are less likely to receive a live-donor kidney transplant than less-deprived individuals. This qualitative study aimed to identify reasons for the observed socioeconomic disparity in live-donor kidney transplantation. Design A qualitative study using face-to-face in-depth semistructured interviews. Setting A UK tertiary renal referral hospital and transplant centre. Participants… Continue reading Socioeconomic deprivation and barriers to live-donor kidney transplantation: a qualitative study of deceased-donor kidne... περισσότερα »
Posterior Reversible Encephalopathy Syndrome and Subarachnoid Hemorrhage After Lumboperitoneal Shunt for Fulminant Idiopathic Intracranial Hypertension.
A 33-year-old woman presented with severe visual loss from fulminant idiopathic intracranial hypertension. Her lumbar puncture opening pressure was 97 cm H2O. Soon after lumboperitoneal shunt surgery, she had a generalized tonic-clonic seizure. Magnetic resonance imaging demonstrated frontal subarachnoid hemorrhage (SAH) and neuroimaging findings consistent with posterior reversible encephalopathy syndrome (PRES). We hypothesize that an… Continue reading Posterior Reversible Encephalopathy Syndrome and Subarachnoid Hemorrhage After Lumboperitoneal Shunt for Fulminant Idiopathic Intr...περισσότερα »
Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a protocol for a scoping review of the literature and international policies
Introduction With ageing comes increased vulnerability such that older adults’ ability to recover from acute illnesses, fall-related injuries and other stresses related to the physical ageing processes declines. This increased vulnerability, also known as frailty, is common in older adults and associated with increased healthcare service use and adverse health outcomes. Currently, there is no… Continue reading Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a protocol for a scoping review of the literature and international policies
Increased Epithelial Gap Density in the Non-Inflamed Duodenum of Children with Inflammatory Bowel Diseases.
Objectives: Inflammatory bowel diseases (IBD) present commonly in childhood, with unknown etiology, but an important role for the epithelial lining is suggested. Epithelial cell extrusion, measured by counting gaps between epithelial cells, is higher in adult Crohn disease (CD) patients than in controls. Our objectives were to compare epithelial gaps in the duodenum of IBD… Continue reading Increased Epithelial Gap Density in the Non-Inflamed Duodenum of Children with Inflammatory Bowel Diseases.
[Radiation treatment of head and neck carcinomas as a risk factor for thyroid carcinomas].
*[Radiation treatment of head and neck carcinomas as a risk factor for thyroid carcinomas].* Hell J Nucl Med. 2016 Mar 1; Authors: Giannoula E, Gkantaifi A, Iakovou I Abstract OBJECTIVE: Cancer of the thyroid is a relatively rare malignant neoplasm with an increasing incidence in the last decades. Ionizing radiation is the best documented risk factor for thyroid malignant neoplasms, in current medical literature. An increase in the global annual per caput effective radiation dose has been described, partly as a result of medical exposure. External beam radiation therapy of the he... περισσότερα »
Une malformation nasale congénitale non retrouvée dans la littérature : à propos de 5 cas
Publication date: Available online 2 March 2016 *Source:*Annales de Chirurgie Plastique Esthétique Author(s): T.R. Colson, B. Bertrand, N. Degardin, J. Bardot, D. Casanova But de l'étudeCinq cas d'une même malformation congénitale du nez sont présentés, dont il ne semble pas exister d'équivalent dans la littérature. Cette malformation touche l'arête nasale et le supra-tip. Nous souhaitions présenter cette pathologie.Patients et méthodesCinq patients présentant une malformation nasale congénitale similaire non décrite dans la littérature ont été pris en charge entre 1994 et 2014. Ces ... περισσότερα »
A new strategy for prophylactic surgery in BRCA women: Combined mastectomy and laparoscopic salpingo-oophorectomy with immediate reconstruction by double DIEP flap
Publication date: Available online 2 March 2016 *Source:*Annales de Chirurgie Plastique Esthétique Author(s): V. Hunsinger, A.C. Marchac, M. Derder, M. Hivelin, F. Lecuru, A.-S. Bats, L. Lantieri BackgroundProphylactic surgery remains the most effective modality for reducing both breast and ovarian cancer rate in woman at high risk, such as BRCA1 or BRCA2. Autologous breast reconstruction with bilateral deep inferior epigastric perforator (DIEP) flap allows predictable and durable results. However, existing two-step approach separating salpingo-oophorectomy and reconstruction could ...περισσότερα »
Investigation of particle dynamics in a rotary drum by means of experiments and numerical simulations using DEM
Publication date: Available online 2 March 2016 Source:Advanced Powder Technology Author(s): Dyrney A. Santos, Marcos A.S. Barrozo, Claudio R. Duarte, Fabian Weigler, Jochen Mellmann The present paper describes an experimental and numerical study conducted to investigate the particle movement inside an unbaffled rotary drum under different operating conditions and using particles of different shapes. The… Continue reading Investigation of particle dynamics in a rotary drum by means of experiments and numerical simulations using DEM
Determinants of infant and young child feeding practices in Rupandehi, Nepal
Abstract Background Undernutrition is a major problem in Nepal and meeting the minimum dietary standard is essential for growth and development of young children. Continuous monitoring of such practices is important to inform policy and program formulation. This study aimed to assess complementary feeding practices, and associated factors in Western Nepal. Methods This was a… Continue reading Determinants of infant and young child feeding practices in Rupandehi, Nepal
Synthesis and formation mechanism of ZrB2–Al2O3 composite powder starting from ZrO2, Al, and BN
Publication date: Available online 2 March 2016 Source:Advanced Powder Technology Author(s): Chunlei Yan, Rongjun Liu, Changrui Zhang, Yingbin Cao, Xianhai Long ZrB2–Al2O3 in situ composite powders were synthesized at 1550°C via a novel solid-state precursor route using ZrO2, Al, and BN as raw materials. The final ZrB2–Al2O3 composite powders, consisting of large crystal Al2O3 particles… Continue reading Synthesis and formation mechanism of ZrB2–Al2O3 composite powder starting from ZrO2, Al, and BN
Prophylaxis and management of postoperative nausea and vomiting in enhanced recovery protocols: Expert Opinion statement from the American Society for Enhanced Recovery (ASER)
Abstract International experience and evidence-based practices have shown that reduction in variability through use of protocolized perioperative care improves surgical outcomes and reduces costs to patients and healthcare systems. In this series of Expert Opinions, we provide consensus recommendations for the various components of perioperative care to aid with the development of enhanced recovery after… Continue reading Prophylaxis and management of postoperative nausea and vomiting in enhanced recovery protocols: Expert Opinion statement from the American Society for Enhanced Rec... περισσότερα »
Peanut Trial LEAPS Back Into Limelight at Allergy MeetingPeanut Trial LEAPS Back Into Limelight at Allergy Meeting
The much-anticipated update from the LEAP study on the protective effects of early peanut exposure in infants will be presented, as will data on the safety of asthma medications. Medscape Medical News (Source: Medscape Allergy Headlines) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QN6Aku via IFTTT
Anticipated regret in shared decision-making: a randomized experimental study
Abstract Background Explicit consideration of anticipated regret is not part of the standard shared decision-making protocols. This pilot study aimed to compare decisions about a hypothetical surgery for breast cancer and examined whether regret is a consideration in treatment decisions. Methods In this randomized experimental study, 184 healthy female volunteers were randomized to receive a… Continue reading Anticipated regret in shared decision-making: a randomized experimental study
Insurance Status and Asthma Exacerbation ManagementInsurance Status and Asthma Exacerbation Management
A new study examines the management of asthma exacerbation in the ED based on health insurance status. How does it impact the level of care? Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health (Source: Medscape Allergy Headlines) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UApcKp via IFTTT
Resolving uncertainty in the spatial relationships between passive benzene exposure and risk of non-Hodgkin lymphoma
Publication date: Available online 2 March 2016 Source:Cancer Epidemiology Author(s): Jeffrey M. Switchenko, Catherine Bulka, Kevin Ward, Jean L. Koff, A. Rana Bayakly, P. Barry Ryan, Lance A. Waller, Christopher R. Flowers BackgroundBenzene is a known occupational carcinogen associated with increased risk of hematologic cancers, but the relationships between quantity of passive benzene exposure through… Continue reading Resolving uncertainty in the spatial relationships between passive benzene exposure and risk of non-Hodgkin lymphoma
Guidelines for the Use of Psoralen-Ultraviolet A TherapyGuidelines for the Use of Psoralen-Ultraviolet A Therapy
These updated guidelines provide evidence-based recommendations for the safe and effective use of psoralen-ultraviolet A photochemotherapy in a wide variety of dermatoses. The British Journal of Dermatology (Source: Medscape Allergy Headlines) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QN6A3O via IFTTT
Roche Suffers Setback as Severe Asthma Drug Fails in One StudyRoche Suffers Setback as Severe Asthma Drug Fails in One Study
Roche suffered a setback in its ambitions to build its presence in the emerging market for biotech asthma drugs on Monday when it announced that one of two identical studies failed to help patients as expected. Reuters Health Information (Source: Medscape Allergy Headlines) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UApb9i via IFTTT
Is the Ambu aScope 3 Slim single-use fiberscope equally efficient compared with a conventional bronchoscope for management of the difficult airway?
[image: gr1.sml] The study objective was to evaluate whether the single-use fiberoptic bronchoscope (FOB), Ambu aScope 3 Slim, was equally efficient compared with the conventional reusable FOB, Olympus LF-GP, for nasal fiberoptic intubation in a manikin. from Anaesthesia via ola Kala on Inoreader http://ift.tt/1oQt5OU via IFTTT
Reply to: blind intubation through Air-Q SP laryngeal mask in morbidly obese patients
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Local anaesthesia for carotid endarterectomy: Pro: protect the brain
No abstract available from Anaesthesia via ola Kala on Inoreader http://ift.tt/21EAId2 via IFTTT
