Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Παρασκευή 11 Μαρτίου 2016

OtoRhinoLaryngology & Medicine,New Articles,March 11th,2016,a


The radioprotective effect of resveratrol on the mandibular incisors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
Micro-CT evaluation of the radioprotective effect of resveratrol on the mandibular incisors of irradiated rats: Abstract The purpose of this study was to perform a microcomputed tomographic evaluation of the radioprotective effect of resveratrol on the volume of mandibular incisors of irradiated rats. A second aim was to make a quantitative assessment of the effect of x-ray exposure on these dental tissues. Twenty adult male rats were divided into four groups: control, irradiated control, resveratrol, and irradiated resveratrol. The resveratrol groups received 100 mg/kg of resveratr... περισσότερα »

Blue Covarine

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
Does a toothpaste containing blue covarine have any effect on bleached teeth? An in vitro, randomized and blinded study: Abstract The objective of this study was to analyze the effect of bleaching toothpastes, both conventional and those containing the new whitening agent Blue Covarine, on teeth previously bleached by conventional techniques (in-office and at-home). Squared bovine enamel/dentin blocks (6.0 x 6.0 x 2.0 mm) were randomly distributed in 6 groups (n = 15), according to the technique used to bleach them (in-office: HP35%; at-home: PC10%) and the type of bleaching toothpa... περισσότερα »

Chlorhexidine (CHX), chloramine T (CHT), triclosan (TRI), and essential oils (EO)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
Antiseptics and microcosm biofilm formation on titanium surfaces: Abstract Oral rehabilitation with osseointegrated implants is a way to restore esthetics and masticatory function in edentulous patients, but bacterial colonization around the implants may lead to mucositis or peri-implantitis and consequent implant loss. Peri-implantitis is the main complication of oral rehabilitation with dental implants and, therefore, it is necessary to take into account the potential effects of antiseptics such as chlorhexidine (CHX), chloramine T (CHT), triclosan (TRI), and essential oils (EO) o... περισσότερα »

Simultaneous urodynamic and anorectal manometry studies in children: insights into the relationship between the lower gastrointestinal and lower urinary tracts

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 3 δευτερόλεπτα
Neurogastroenterology & Motility from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1UXESYm via IFTTT

Bedbugs infest Tenn. ambulance service

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 3 δευτερόλεπτα
One employee noticed bug bites; the service's two stations and all of the ambulances have been treated from EMS via xlomafota13 on Inoreader http://ift.tt/1QMrDYJ via IFTTT

Evidence-based guidelines for recommending cochlear implantation for postlingually deafened adults.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 4 δευτερόλεπτα
*Evidence-based guidelines for recommending cochlear implantation for postlingually deafened adults.* Int J Audiol. 2016 Mar 10;:1-6 Authors: Leigh JR, Moran M, Hollow R, Dowell RC Abstract OBJECTIVE: Adult selection criteria for cochlear implantation have been developed based on analysis of the post-operative performance of a large group of postlingually deafened adults. Original criteria published in 2004 were reviewed and amended to reflect outcomes currently being achieved by implant recipients. DESIGN: Retrospective review of 12-month post-operative speech perception perform... περισσότερα »

D-methionine (D-met) significantly reduces kanamycin-induced ototoxicity in pigmented guinea pigs.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 4 δευτερόλεπτα
*D-methionine (D-met) significantly reduces kanamycin-induced ototoxicity in pigmented guinea pigs.* Int J Audiol. 2016 Mar 10;:1-6 Authors: Campbell KC, Martin SM, Meech RP, Hargrove TL, Verhulst SJ, Fox DJ Abstract OBJECTIVE: Test D-methionine (D-met) as an otoprotectant from kanamycin-induced ototoxicity and determine the lowest maximally protective D-met dose. DESIGN: Auditory brainstem responses (ABR) were measured at 4, 8, 14, and 20 kHz at baseline and two, four, and six weeks after kanamycin and D-met administration initiation. ABR threshold shifts assessed auditory functi...περισσότερα »

Psychometric properties of a Mandarin version of the tinnitus questionnaire.

Alexandros G. SfakianakisστοΑκοή και ΙσορροπίαΠριν από 4 δευτερόλεπτα
*Psychometric properties of a Mandarin version of the tinnitus questionnaire.* Int J Audiol. 2016 Mar 10;:1-9 Authors: Meng Z, Chen Z, Xu K, Li G, Tao Y, Kwong JS Abstract OBJECTIVE: To develop a Mandarin version of the tinnitus questionnaire (MTQ) and determine the reliability and validity, and to assess whether it could be used clinically in the Chinese population. DESIGN: The MTQ, short-form (36) health survey, hospital anxiety and depression scale, Mandarin (Chinese) tinnitus handicap inventory, and visual analogue scale were completed by the participants. STUDY SAMPLE: We inc...περισσότερα »

Antiseptics and microcosm biofilm formation on titanium surfaces

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Antiseptics and microcosm biofilm formation on titanium surfaces: Abstract Oral rehabilitation with osseointegrated implants is a way to restore esthetics and masticatory function in edentulous patients, but bacterial colonization around the implants may lead to mucositis or peri-implantitis and consequent implant loss. Peri-implantitis is the main complication of oral rehabilitation with dental implants and, therefore, it is necessary to take into account the potential effects of antiseptics such as chlorhexidine (CHX), chloramine T (CHT), triclosan (TRI), and essential oils (EO) o... περισσότερα »

Interaction between IRF6 and TGFA Genes Contribute to the Risk of Nonsyndromic Cleft Lip/Palate

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Interaction between IRF6 and TGFA Genes Contribute to the Risk of Nonsyndromic Cleft Lip/Palate: Previous evidence from tooth agenesis studies suggested *IRF6* and *TGFA* interact. Since tooth agenesis is commonly found in individuals with cleft lip/palate (CL/P), we used four large cohorts to evaluate if *IRF6* and *TGFA* interaction contributes to CL/P. Markers within and flanking *IRF6* and *TGFA* genes were tested using Taqman or SYBR green chemistries for case-control analyses in 1,000 Brazilian individuals. We looked for evidence of gene-gene interaction between *IRF6* and *TG...περισσότερα »

Maternal Transmission Effect of a PDGF-C SNP on Nonsyndromic Cleft Lip with or without Palate

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Maternal Transmission Effect of a PDGF-C SNP on Nonsyndromic Cleft Lip with or without Palate from a Chinese Population: Cleft lip with or without palate (CL/P) is a common congenital anomaly with a high birth prevalence in China. Based on a previous linkage signal of nonsyndromic CL/P (NSCL/P) on the chromosomal region 4q31–q32 from the Chinese populations, we screened the 4q31–q32 region for susceptibility genes in 214 trios of Han Chinese. *PDGF-C*, an important developmental factor, resides in the region and has been implicated in NSCL/P. However, in our family-based associat... περισσότερα »

Congenital Heart Disease and Other Organic Malformations Associated with Different Types of Orofacial Clefts

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
A Survey of Congenital Heart Disease and Other Organic Malformations Associated with Different Types of Orofacial Clefts in Eastern China: Background A high incidence of orofacial clefts is reported in China, but no data has shown the relation between cleft types and the incidence of other defects so far. The aim of this study is to assess the incidence of congenital heart diseases and other organic defects associated with different types of orofacial clefts. Methodology and Principal Findings All children with orofacial clefts, which were sought out from the Health Information ... περισσότερα »

Maternal Age, Parity and Isolated Birth Defects

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Maternal Age, Parity and Isolated Birth Defects: A Population-Based Case-Control Study in Shenzhen, China: Background The etiology of birth defects has been widely studied but is not yet fully clarified, previously published data had suggested that maternal age or parity maybe involved, but without consistent conclusions. Methods A population-based, case-control study was nested in a cohort of perinatal infants born from 2010 to 2012 in Baoan District, Shenzhen. Four categories of isolated birth defects were defined as cases: congenital heart defects (CHD, n = 693), polydacty... περισσότερα »

Association between MTHFR C677T and A1298C Polymorphisms and NSCL/P

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Association between MTHFR C677T and A1298C Polymorphisms and NSCL/P Risk in Asians: A Meta-Analysis: Objective Several studies have reported the association between methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and nonsyndromic cleft lip with or without palate (NSCL/P) in Asian populations. However, findings have been conflicting. In order to investigate the association, a meta-analysis was performed. Methods We searched Pubmed, MedLine and EmBase database to selected eligible studies. The pooled odds ratios (ORs) with 95% confidence intervals (95%CI... περισσότερα »

Botulinum Toxin to Improve Results in Cleft Lip Repair

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
Botulinum Toxin to Improve Results in Cleft Lip Repair: A Double-Blinded, Randomized, Vehicle-Controlled Clinical Trial: Background Most patients with facial scarring would value even a slight improvement in scar quality. Botulinum toxin A is widely used to alleviate facial dynamic rhytides but is also believed to improve scar quality by reducing wound tension during healing. The main objective was to assess the effect of Botulinum toxin on scars resultant from standardized upper lip wounds. Methods In this double-blinded, randomized, vehicle-controlled, prospective clinical tria... περισσότερα »

Genetic Disruption of the Sh3pxd2a Gene Reveals an Essential Role in Mouse Development and the Existence of a Novel Isoform of Tks5

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Genetic Disruption of the Sh3pxd2a Gene Reveals an Essential Role in Mouse Development and the Existence of a Novel Isoform of Tks5: Tks5 is a scaffold protein and Src substrate involved in cell migration and matrix degradation through its essential role in invadosome formation and function. We have previously described that Tks5 is fundamental for zebrafish neural crest cell migration *in vivo*. In the present study, we sought to investigate the function of Tks5 in mammalian development by analyzing mice mutant for *sh3pxd2a*, the gene encoding Tks5. Homozygous disruption of the *s...περισσότερα »

Accelerated Wound Closure In Vitro by Fibroblasts from a Subgroup of Cleft Lip/Palate Patients: Role of Transforming Growth Factor-α

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Accelerated Wound Closure In Vitro by Fibroblasts from a Subgroup of Cleft Lip/Palate Patients: Role of Transforming Growth Factor-α: In a fraction of patients surgically treated for cleft lip/palate, excessive scarring disturbs maxillary growth and dento-alveolar development. Since certain genes are involved in craniofacial morphogenesis as well as tissue repair, a primary defect causing cleft lip/palate could lead to altered wound healing. We performed *in vitro* wound healing assays with primary lip fibroblasts from 16 cleft lip/palate patients. Nine foreskin fibroblast strains ... περισσότερα »

The Ubiquitin E3 Ligase NOSIP Modulates Protein Phosphatase 2A Activity in Craniofacial Development

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
The Ubiquitin E3 Ligase NOSIP Modulates Protein Phosphatase 2A Activity in Craniofacial Development: Holoprosencephaly is a common developmental disorder in humans characterised by incomplete brain hemisphere separation and midface anomalies. The etiology of holoprosencephaly is heterogeneous with environmental and genetic causes, but for a majority of holoprosencephaly cases the genes associated with the pathogenesis could not be identified so far. Here we report the generation of knockout mice for the ubiquitin E3 ligase NOSIP. The loss of NOSIP in mice causes holoprosencephaly an... περισσότερα »

Nasoalveolar Molding in Cleft Care

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Nasoalveolar Molding in Cleft Care—Experience in 40 Patients from a Single Centre in Germany: Nasoalveolar molding (NAM) has gained wide acceptance and evidence in cleft therapy. However, standardized treatment protocols and experiences recorded from European centres are lacking. The results of 40 infants with cleft lip and palate treated with presurgical NAM according to the Grayson technique were analyzed. Standardized parameters of cleft width and nasal symmetry were measured in pre- and posttreatment plaster casts and in digitalized 3-dimensional STL models. Statistical analys... περισσότερα »

Passive Smoking in the Etiology of Non-Syndromic Orofacial Clefts

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Passive Smoking in the Etiology of Non-Syndromic Orofacial Clefts: A Systematic Review and Meta-Analysis: Background Studies have found a consistent positive association between maternal smoking and non-syndromic orofacial clefts (NSOFC). However, no comprehensive assessment of the association between NSOFC and passive smoking has been undertaken. This systematic review and meta-analysis explores the relationship between maternal passive smoking and NSOFC, and compares the associations between passive and active smoking. Methods and Findings Search strategy, inclusion / exclusion... περισσότερα »

Birth Prevalence of Neural Tube Defects and Orofacial Clefts

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Birth Prevalence of Neural Tube Defects and Orofacial Clefts in India: A Systematic Review and Meta-Analysis: Background In the last two decades, India has witnessed a substantial decrease in infant mortality attributed to infectious disease and malnutrition. However, the mortality attributed to birth defects remains constant. Studies on the prevalence of birth defects such as neural tube defects and orofacial clefts in India have reported inconsistent results. Therefore, we conducted a systematic review of observational studies to document the birth prevalence of neural tube defec... περισσότερα »

Hedgehog Pathway Antagonist-Induced Holoprosencephaly, Cleft Lip, and Cleft Palate

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Definition of Critical Periods for Hedgehog Pathway Antagonist-Induced Holoprosencephaly, Cleft Lip, and Cleft Palate: The Hedgehog (Hh) signaling pathway mediates multiple spatiotemporally-specific aspects of brain and face development. Genetic and chemical disruptions of the pathway are known to result in an array of structural malformations, including holoprosencephaly (HPE), clefts of the lip with or without cleft palate (CL/P), and clefts of the secondary palate only (CPO). Here, we examined patterns of dysmorphology caused by acute, stage-specific Hh signaling inhibition. Time... περισσότερα »

Ectrodactyly ectodermal dysplasia cleft lip/palate (EEC) syndrome and limb-mammary syndrome (LMS)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Differentially Expressed Genes in EEC and LMS Syndromes: Objectives Ectrodactyly ectodermal dysplasia cleft lip/palate (EEC) syndrome and limb-mammary syndrome (LMS) share a similar phenotype and the same pathogenic gene, which complicates the ability to distinguish between these diagnoses. The current study aims to identify a potential and practical clinical biomarker to distinguish EEC from LMS. Methods Two EEC pedigrees and one LMS pedigree that have been previously reported were reanalyzed. After confirmation of the causative mutations for these new patients, whole-genome exp... περισσότερα »

Molecular Anatomy of Palate Development

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Molecular Anatomy of Palate Development: The NIH FACEBASE consortium was established in part to create a central resource for craniofacial researchers. One purpose is to provide a molecular anatomy of craniofacial development. To this end we have used a combination of laser capture microdissection and RNA-Seq to define the gene expression programs driving development of the murine palate. We focused on the E14.5 palate, soon after medial fusion of the two palatal shelves. The palate was divided into multiple compartments, including both medial and lateral, as well as oral and nasal,...περισσότερα »

Altered FGF Signaling Pathways Impair Cell Proliferation and Elevation of Palate Shelves

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Altered FGF Signaling Pathways Impair Cell Proliferation and Elevation of Palate Shelves: In palatogenesis, palatal shelves are patterned along the mediolateral axis as well as the anteroposterior axis before the onset of palatal fusion. *Fgf10* specifically expressed in lateral mesenchyme of palate maintains *Shh* transcription in lateral epithelium, while *Fgf7* activated in medial mesenchyme by *Dlx5*, suppressed the expansion of *Shh* expression to medial epithelium. How FGF signaling pathways regulate the cell behaviors of developing palate remains elusive. In our study, we foun... περισσότερα »

Cleft Palate, Moderate Lung Developmental Retardation and Early Postnatal Lethality in Mice Deficient in the Kir7.1 Inwardly Rectifying K+ Channel

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Cleft Palate, Moderate Lung Developmental Retardation and Early Postnatal Lethality in Mice Deficient in the Kir7.1 Inwardly Rectifying K+ Channel: Kir7.1 is an inwardly rectifying K+ channel of the Kir superfamily encoded by the *kcnj13* gene. Kir7.1 is present in epithelial tissues where it colocalizes with the Na+/K+-pump probably serving to recycle K+ taken up by the pump. Human mutations affecting Kir7.1 are associated with retinal degeneration diseases. We generated a mouse lacking Kir7.1 by ablation of the *Kcnj13* gene. Homozygous mutant null mice die hours after birth and s... περισσότερα »

Epidemiology of Birth Defects Based on a Birth Defect Surveillance System

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Epidemiology of Birth Defects Based on a Birth Defect Surveillance System from 2005 to 2014 in Hunan Province, China: Objective To describe the epidemiology of birth defects (BDs) in perinatal infants in Hunan Province, China, between 2005 and 2014. Methods The BD surveillance data of perinatal infants (for stillbirth, dead fetus or live birth between 28 weeks of gestation and 7 days after birth) were collected from 52 registered hospitals of Hunan between 2005 and 2014. The prevalence rates of BDs with 95% confidence interval (CI) and crude odds ratio (ORs) were calculated to ex... περισσότερα »

G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis: The heterotrimeric G protein subunit Gsα couples receptors to activate adenylyl cyclase and is required for the intracellular cAMP response and protein kinase A (PKA) activation. Gsα is ubiquitously expressed in many cell types; however, the role of Gsα in neural crest cells (NCCs) remains unclear. Here we report that NCCs-specific *Gsα* knockout mice die within hours after birth and exhibit dramatic craniofacial malformations, including hypoplastic maxilla and mandible, cleft palate and craniofacial skeleton ...περισσότερα »

Epidemiologic Research on Malformations Associated with Cleft Lip and Cleft Palate in Japan

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Epidemiologic Research on Malformations Associated with Cleft Lip and Cleft Palate in Japan: To investigate malformations associated with cleft lip and cleft palate, we conducted surveys at neonatal intensive care units (NICUs) and other non-NICU facilities and to determine whether there are differences among facilities. The regional survey investigated NICU facilities located in Oita Prefecture, including 92 patients with cleft lip and palate (CLP) or cleft palate (CP) that occurred between 2004 and 2013, and the national survey investigated oral surgery, plastic surgery, and obste... περισσότερα »

Atrophy of the anterior digastric muscle

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Atrophy of the anterior digastric muscle: response to a prospective clinical study: Gibson et al.,1 recently studied 1484 ultrasound examinations of the neck, done by a single operator, in which they found an absent or atrophied anterior belly of the digastric muscle in three women (0.2%). They also noted that other variations, aside from those in the three females, were not found during their ultrasound examination.1

Investigating Helmet Promotion for Cyclists

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Investigating Helmet Promotion for Cyclists: Results from a Randomised Study with Observation of Behaviour, Using a Semi-Automatic Video System: Introduction Half of fatal injuries among bicyclists are head injuries. While helmet use is likely to provide protection, their use often remains rare. We assessed the influence of strategies for promotion of helmet use with direct observation of behaviour by a semi-automatic video system. Methods We performed a single-centre randomised controlled study, with 4 balanced randomisation groups. Participants were non-helmet users, aged 18–...περισσότερα »

Lgr5 Identifies Progenitor Cells Capable of Taste Bud Regeneration after Injury

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Lgr5 Identifies Progenitor Cells Capable of Taste Bud Regeneration after Injury: Taste buds are composed of a variety of taste receptor cell types that develop from tongue epithelium and are regularly replenished under normal homeostatic conditions as well as after injury. The characteristics of cells that give rise to regenerating taste buds are poorly understood. Recent studies have suggested that *Lgr5* (leucine-rich repeat-containing G-protein coupled receptor 5) identifies taste bud stem cells that contribute to homeostatic regeneration in adult circumvallate and foliate taste ... περισσότερα »

Treatment of Mandibular Condyle Fractures Using a Modified Transparotid Approach via the Parotid Mini-Incision: Experience with 31 Cases

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Treatment of Mandibular Condyle Fractures Using a Modified Transparotid Approach via the Parotid Mini-Incision: Experience with 31 Cases: Surgery for mandibular condyle fractures must allow direct vision of the fracture, reduce surgical trauma and achieve reduction and fixation while avoiding facial nerve injury. This prospective study was conducted to introduce a new surgical approach for open reduction and internal fixation of mandibular condyle fractures using a modified transparotid approach via the parotid mini-incision, and surgical outcomes were evaluated. The modified transp...περισσότερα »

Diagnostic Radiation Exposure of Injury Patients in the Emergency Department: A Cross-Sectional Large Scaled Study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Diagnostic Radiation Exposure of Injury Patients in the Emergency Department: A Cross-Sectional Large Scaled Study: In contrast to patients with underlying cancer or chronic disease, injury patients are relatively young, and can be expected to live their natural lifespan if injuries are appropriately treated. Multiple and repeated diagnostic scans might be performed in these patients during admission. Nevertheless, radiation exposure in injury patients has been overlooked and underestimated because of the emergent nature of such situations. Therefore, we tried to assess the cumulati...περισσότερα »

Mucosal leishmaniasis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
in Brazilian patients: two case reports with similar clinical presentation and different approaches via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 10 March 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Aline Fernanda Cruz, Renata Gonçalves Resende, Daniel Ricaldoni Albuquerque, Júlio César Tanos de Lacerda, Camila Ferreira Leite, Maria Cássia Ferreira Aguiar Mucosal leishmaniasis (ML) is a chronic infection that affects the upper respiratory tract and/or oral mucosa, caused by Leishmania pr...περισσότερα »

Oral Herpetic Lesion

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
AAOM Clinical Practice Statement Subject: Dental Care for the Patient with an via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 10 March 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Craig S. Miller PurposeThe AAOM affirms that treatment of dental patients should encompass recognition of infectious diseases that can manifest in the orofacial region, implementation of disease management, and prevention of disease transmission. Further, the AAOM recommends education and training regarding infec... περισσότερα »

Oral Contact Allergy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
The American Academy of Oral Medicine Clinical Practice Statement: via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 10 March 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Eric T. Stoopler, Scott S. De Rossi PurposeThe AAOM affirms that oral contact allergy (OCA) is an oral mucosal response that may be associated with materials and substances found in oral hygiene products, common food items, and topically applied agents. The AAOM also affirms that patients with suspected OCA should be referred...περισσότερα »

Endoscopic endonasal anterior skull base surgery: a systematic review of complications over the past 65 years.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
*Endoscopic endonasal anterior skull base surgery: a systematic review of complications over the past 65 years.* World Neurosurg. 2016 Mar 4; Authors: Borg A, Kirkman MA, Choi D Abstract BACKGROUND: Endoscopic skull base surgery is becoming more popular as an approach to the anterior skull base for tumors and CSF fistulae. It offers the advantages of better cosmesis and improved quality of life after surgery. We reviewed the complication rates reported in the literature. METHODS: A literature search was performed using the electronic database Ovid MEDLINE (1950 to 25(th) August 20...περισσότερα »

[Epidemiology and etiology of posterior fossa tumors with particular emphasis on astrocytomas from the Małopolska and Podkarpacki regions].

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
Related Articles *[Epidemiology and etiology of posterior fossa tumors with particular emphasis on astrocytomas from the Małopolska and Podkarpacki regions].* Przegl Lek. 2015;72(8):435-9 Authors: Ciepiela L, Ciepiela K, Kwiatkowski S Abstract Brain tumors in children are rare compared with other diseases childhood. Virtually every pediatrician working at the local hospital has been in contact or brain tumor diagnosis was that more half of them recognized the posterior fossa tumor. Analysis of surveys showed difficulties in the interpretation of basic neurological symptoms. Lesso... περισσότερα »

An Unusually Benign Course of Extensive Posterior Circulation Occlusion.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *An Unusually Benign Course of Extensive Posterior Circulation Occlusion.* J Stroke Cerebrovasc Dis. 2015 Jul;24(7):e165-8 Authors: Datar S, Lanzino G, Rabinstein AA Abstract BACKGROUND: Acute basilar artery occlusion is associated with poor outcome. In a few cases, occlusion occurs over a period allowing adequate collateral circulation to the posterior fossa. We describe a rare presentation with transient loss of consciousness (LOC) in a patient with extensive occlusion of the posterior circulation. METHODS: Case ... περισσότερα »

Therapeutic role of Vitamin B12 in patients of chronic tinnitus: A pilot study.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
*Therapeutic role of Vitamin B12 in patients of chronic tinnitus: A pilot study.* Noise Health. 2016 Mar-Apr;18(81):93-7 Authors: Singh C, Kawatra R, Gupta J, Awasthi V, Dungana H Abstract True tinnitus is a phantom auditory perception arising from a source or trigger in the cochlea, brainstem, or at higher centers and has no detectable acoustic generator. The most accepted is the famous neurophysiologic model of Jastreboff, which stresses that tinnitus, is a subcortical perception and results from the processing of weak neural activity in the periphery. The aim of this study is ... περισσότερα »

upper respiratory tract infection; +48 new citations

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
48 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2016/03/11 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1TRPby3 via IFTTT

Prognostic factors in patients with primary hemangiopericytomas of the central nervous system: a series of 103 cases at a single institution.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
*Prognostic factors in patients with primary hemangiopericytomas of the central nervous system: a series of 103 cases at a single institution.* World Neurosurg. 2016 Mar 4; Authors: Zhu H, Duran D, Hua L, Tang H, Chen H, Zhong P, Zheng K, Wang Y, Che X, Bao W, Wang Y, Xie Q, Gong Y Abstract OBJECTIVE: Hemangiopericytoma (HPC) is a rare mesenchymal tumor that tends to affect the central nervous system and is associated with distant metastasis and a high recurrence rate. The purpose of this study was to analyze the prognostic factors in surgically treated patients with primary HPC....περισσότερα »

Patterns of recurrence after resection of malignant gliomas with BCNU wafer implants: retrospective review in a single institution.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
*Patterns of recurrence after resection of malignant gliomas with BCNU wafer implants: retrospective review in a single institution.* World Neurosurg. 2016 Mar 4; Authors: Shimato S, Nishizawa T, Ohshima T, Imai T, Goto S, Yamamoto T, Kato K PMID: 26960286 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1TRPbhF via IFTTT

Techniques and outcomes of Gore-Tex clip-wrapping of ruptured and unruptured cerebral aneurysms.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
*Techniques and outcomes of Gore-Tex clip-wrapping of ruptured and unruptured cerebral aneurysms.* World Neurosurg. 2016 Mar 4; Authors: Safavi-Abbasi S, Moron F, Sun H, Wilson C, Frock B, Oppenlander ME, Xu DS, Ghafil C, Zabramski JM, Spetzler RF, Nakaji P Abstract OBJECTIVE: Some aneurysms without a definable neck and associated parent vessel pathology are particularly difficult to treat and may require clipping with circumferential wrapping. This is the largest available contemporary series examining the techniques of Gore-Tex clip-wrapping of ruptured and unruptured intracran...περισσότερα »

Sacral nerve stimulation for neurogenic bladder.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
*Sacral nerve stimulation for neurogenic bladder.* World Neurosurg. 2016 Mar 4; Authors: Li LF, Leung GK, Lui WM Abstract Neurogenic bladder refers to the dysfunction of the urinary bladder due to diseases of the nervous system that result in problems with either urine storage, micturition or both. The most common causes included multiple sclerosis and spinal cord injury (SCI). Patients commonly present with recurrent urinary tract infections, obstructive uropathies and urinary retention. Without proper treatment, neurogenic bladder may result in nephropathy and renal failure tha... περισσότερα »

The philosophy of Kaizen and Telemedicine.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 δευτερόλεπτα
*The philosophy of Kaizen and Telemedicine.* World Neurosurg. 2016 Mar 4; Authors: Van Dellen JR PMID: 26960283 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1SFdVIk via IFTTT

Breast Cancer Research and Treatment, Vol. 155, Issue 3 - New Issue Alert

Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 21 δευτερόλεπτα
If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 03/11/2016 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *Breast Cancer Research and Treatment*. Volume 155 Number 3 is now available online. In this issue Editorial Note of clarification regarding data about the association between the interleukin-1β −31T>C polymorphism and breast cancer risk Yadong Wang, Yan Wang & Li Li » Abstract » Full text HTML » Full text PDF Editorial Note of clarification regar... περισσότερα »

AIDS and Behavior, Vol. 20, Issue 3 - New Issue Alert

Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 21 δευτερόλεπτα
If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 03/11/2016 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *AIDS and Behavior*. Volume 20 Number 3 is now available online. In this issue Original Paper Armed Conflict, Substance Use and HIV: A Global Analysis Bradley T. Kerridge, Tulshi D. Saha & Deborah S. Hasin » Abstract » Full text HTML » Full text PDF Substantive Review HIV-Alcohol Risk Reduction Interventions in Sub-Saharan Africa: A Systematic Revi... περισσότερα »

The effect of direction of force to the craniofacial skeleton on the severity of brain injury in patients with a fronto-basal fracture

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
The effect of direction of force to the craniofacial skeleton on the severity of brain injury in patients with a fronto-basal fracture: The skull base is uniquely positioned to absorb force imparted to the craniofacial skeleton, thereby reducing brain injury. Less well understood is the effect of the direction of force imparted to the craniofacial skeleton on the severity of brain injury. Eighty-one patients from two UK major trauma centres who sustained a fronto-basal fracture were divided into two groups: those struck with predominantly anterior force and those by predominantly la... περισσότερα »

Osseous genioplasty in conjunction with bimaxillary orthognathic surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Osseous genioplasty in conjunction with bimaxillary orthognathic surgery: a review of 262 consecutive cases: The purpose of this study was to evaluate the results of osseous genioplasty with bimaxillary orthognathic surgery. A retrospective consecutive case series of patients treated by a single surgeon between 2004 and 2013 was studied. All underwent Le Fort I, sagittal ramus osteotomies, septoplasty, inferior turbinate reduction, and osseous genioplasty. The outcome variables included the presenting chin dysmorphology, complications, and assessment of morphologic change. A Steiner...περισσότερα »

Coronoid Process Graft and Costochondral Graft in the Reconstruction of Temporomandibular Joint

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
A Comparison of the Effect Between Coronoid Process Graft and Costochondral Graft in the Reconstruction of Temporomandibular Joint: [image: image]Purpose: Bone graft to reconstruct the temporomandibular joint for ankylosis patient is effective. This study used three-dimensional measurement to evaluate the effect between free coronoid process graft (CPG) and costochondral graft (CCG) in the temporomandibular joint reconstruction. Methods: Patients treated with CPG or CCG from 2011 to 2014 were included in the study. Postoperative computed tomography scan data within 1 week and during... περισσότερα »

A Three-dimensional Analysis of Zygomatic Symmetry in Normal, Uninjured Faces

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
A Three-dimensional Analysis of Zygomatic Symmetry in Normal, Uninjured Faces: [image: image] Abstract Abstract: Current approaches to facial reconstruction are based on the assumption of facial symmetry, though this has yet to be established in the literature. Through quantitative and qualitative analysis, symmetry of normal, male faces is examined here using the zygomatic complex as a bellwether for the rest of the facial skeleton. Three-dimensional models reconstructed from the computed tomography scans of 30 adult male patients displaying normal facial skeletal anatomy we...περισσότερα »

The Deltopectoral Flap Revisited: The Internal Mammary Artery Perforator Flap

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
The Deltopectoral Flap Revisited: The Internal Mammary Artery Perforator Flap: [image: image]Abstract: Pharyngo-esophageal and tracheostomal defects pose a challenge in head and neck reconstruction whenever microanastomosis is extremely difficult in hostile neck that is previously dissected and irradiated. The deltopectoral (DP) flap was initially described as a pedicled flap for such reconstruction with acceptable postoperative results. A major drawback is still that the DP flap is based on 3 perforator vessels leading to a decreased arc of rotation. The DP flap also left contour d...περισσότερα »

Predictors of Outcome in Patients Presenting with Acute Ischemic Stroke and Mild Stroke Scale Scores.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 24 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Predictors of Outcome in Patients Presenting with Acute Ischemic Stroke and Mild Stroke Scale Scores.* J Stroke Cerebrovasc Dis. 2015 Jul;24(7):1685-9 Authors: Kenmuir CL, Hammer M, Jovin T, Reddy V, Wechsler L, Jadhav A Abstract BACKGROUND: Although National Institutes of Health Stroke Scale (NIHSS) is a known predictor of outcome in acute ischemic stroke, there are other factors like age, ambulatory status, and ability to swallow that may be predictors of outcome but are not assessed by the traditional NIHSS. Th... περισσότερα »

[Aural Stimulation with Capsaicin Ointment Improved the Swallowing Function in Patients with Dysphagia: Evaluation by the SMRC Scale].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 24 δευτερόλεπτα
Related Articles *[Aural Stimulation with Capsaicin Ointment Improved the Swallowing Function in Patients with Dysphagia: Evaluation by the SMRC Scale].* Nihon Jibiinkoka Gakkai Kaiho. 2015 Nov;118(11):1319-26 Authors: Kondo E, Jinnouchi O, Ohnishi H, Kawata I, Takeda N Abstract Cough and swallowing reflexes are important airway-protective mechanisms against aspiration. Angiotensin-converting enzyme (ACE) inhibitors, one of the side effects of which is cough, have been reported to reduce the incidence of aspiration pneumonia in hypertensive patients with stroke. ACE inhibitors ha... περισσότερα »

[Case of achalasia].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 24 δευτερόλεπτα
Related Articles *[Case of achalasia].* Zhongguo Zhen Jiu. 2015 Oct;35(10):1084 Authors: Zheng R, Zhao S PMID: 26790232 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via a.lsfakia on Inoreader http://ift.tt/1XhDs9L via IFTTT

Age-Related Changes Between the Level of Velopharyngeal Closure and the Cervical Spine

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
Age-Related Changes Between the Level of Velopharyngeal Closure and the Cervical Spine: [image: image]Abstract: The primary focus of this study was to assess age-related changes in the vertical distance of the estimated level of velopharyngeal closure in relation to a prominent landmark of the cervical spine: the anterior tubercle of cervical vertebra 1 (C1). Midsagittal anatomic magnetic resonance images were examined across 51 participants with normal head and neck anatomy between 4 and 17 years of age. Results indicate that age is a strong predictor (P = 0.002) of the vertical ...περισσότερα »

Study of Genial Tubercles of Craniofacial Anomalies Individuals on Cone Beam Computed Tomography Scans

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Study of Genial Tubercles of Craniofacial Anomalies Individuals on Cone Beam Computed Tomography Scans: [image: image] Purpose: Genial tubercles (GTs) are bony protuberances on the lingual aspect of the mandible symphysis, where genioglossus and geniohyoid muscles are inserted. In the literature, few papers report their real dimensions. Cleft lip and palate are craniofacial anomalies involving the maxilla, but the anatomical structures of the mandible can be altered when these have associated with the cleft, some syndrome. This study aimed to evaluate the GTs of 30 individuals and ...περισσότερα »

Expression profiling of small intestinal neuroendocrine tumors identifies subgroups with clinical relevance, prognostic markers and therapeutic targets

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
*Expression profiling of small intestinal neuroendocrine tumors identifies subgroups with clinical relevance, prognostic markers and therapeutic targets* Modern Pathology advance online publication, March 11 2016. doi:10.1038/modpathol.2016.48 Authors: Ellinor Andersson, Yvonne Arvidsson, Christina Swärd, Tobias Hofving, Bo Wängberg, Erik Kristiansson & Ola Nilsson from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1pkkcOj via IFTTT

High prevalence of TERT promoter mutations in primary squamous cell carcinoma of the urinary bladder

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
*High prevalence of TERT promoter mutations in primary squamous cell carcinoma of the urinary bladder* Modern Pathology advance online publication, March 11 2016. doi:10.1038/modpathol.2016.53 Authors: Morgan Cowan, Simeon Springer, Doreen Nguyen, Diana Taheri, Gunes Guner, Maria Angelica Mendoza Rodriguez, Yuxuan Wang, Isaac Kinde, Christopher J Vanden Bussche, Matthew T Olson, Isabela Cunha, Kazutoshi Fujita, Dilek Ertoy, Trinity J Bivalacqua, Kenneth Kinzler, Bert Vogelstein, George J Netto & Nickolas Papadopoulos from Anatomy Pathology via xlomafota13 on Inoreader http://ift... περισσότερα »

Shape and Height of Tarsal Plates

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Shape and Height of Tarsal Plates: Abstract: The aim of this study is to elucidate the anatomic detail of the shape and height of the tarsal plates in Koreans. Fifty-four eyelids from Korean adult cadavers were used. Skin, subcutaneous tissue, and the orbicularis oculi muscle were all removed and the tarsal plates were exposed. The shapes of the tarsal plates were observed and the vertical heights of the tarsal plates were measured at its 1/4 (medial), 2/4 (central), and 3/4 (lateral) horizontal length. Tarsal plates were semilunar shaped and classified into 3 types: symmetric, med... περισσότερα »

Acquired Brown Syndrome Treated With Traction of Superior Oblique Tendon

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Acquired Brown Syndrome Treated With Traction of Superior Oblique Tendon: [image: image]Abstract: Brown syndrome is a rare strabismic disease characterized by a limited elevation in adduction of the eye. The lengthening/weakening of superior oblique muscle is the main way of surgical intervention for this disease. A 7-year-old boy was diagnosed as having acquired Brown syndrome in his right eye after injury in his face. We experienced successful release of this Brown syndrome through mere pulling outward of superior oblique tendon during surgical exploration. We briefly discuss why ... περισσότερα »

Interhemispheric inhibition is dynamically regulated during action observation

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 28 δευτερόλεπτα
Publication date: Available online 10 March 2016 *Source:*Cortex Author(s): Nicolas Gueugneau, Marco Bove, Yves Ballay, Charalambos Papaxanthis It is now well established that the motor system plays a pivotal role in action observation and that the neurophysiological processes underlying perception and action overlaps. However, while various experiments have shown a specific facilitation of the contralateral motor cortex during action observation, no information is available concerning the dynamics of interhemispheric interactions. The aim of the present study was, therefore, to as... περισσότερα »

Coexistence of Wormian Bones With Metopism, and Vice Versa, in Adult Skulls

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Coexistence of Wormian Bones With Metopism, and Vice Versa, in Adult Skulls: Abstract Objective: The aim of the study is to investigate coexistence of Wormian bones with metopism, and vice versa, in adult skulls. Materials and Methods: A total of 160 dry adult human skulls of unknown sex and ages were randomly selected from the Gross Anatomy Laboratory of Medical School of Dokuz Eylul University. The skulls were examined for presence of metopism, Wormian bones (WB), and coexistence of WBs with metopism and vice versa. Topographic distribution of the WBs was macroscopically evalu...περισσότερα »

Functional Assessments in Patients Undergoing Radial Forearm Flap Following Hemiglossectomy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Functional Assessments in Patients Undergoing Radial Forearm Flap Following Hemiglossectomy: [image: image]Abstract: Our goal was to evaluate the functional outcomes following radial forearm free-flap reconstruction with a focus on radiotherapy. A 2-year prospective study was performed. A total of 47 patients were enrolled finally. They were asked to complete the swallowing, chewing, speech domains of the University of Washington Quality of Life questionnaire preoperatively and at 2 years postoperatively. Swallowing capacity was apparently affected after surgery, but no patients rep... περισσότερα »

Surface Reconstruction and Optimization of Cerebral Cortex for Application Use

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Surface Reconstruction and Optimization of Cerebral Cortex for Application Use: [image: image]Abstract: For the purposes of virtual surgery, medical education, medical communication, and realistic surface models of anatomic structures are required. In the most involved method, surface models can be made using segmentation and three-dimensional reconstruction procedures. Such models, however, are computationally expensive, and can be difficult to use. Therefore, optimization is often performed manually, but this is a time-consuming job that requires considerable artistic talent. In th...περισσότερα »

A Different Cartilage Graft Technique: Perichondrium-Preserved Palisade Island Graft in Tympanoplasty

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
A Different Cartilage Graft Technique: Perichondrium-Preserved Palisade Island Graft in Tympanoplasty: [image: image] Abstract Abstract: Various graft materials have been used since tympanoplasty technique was first described. In this study, the authors aimed to share our modified island cartilage graft technique. A total of 47 ears of 46 patients on whom tympanoplasty or tympanomastoidectomy operation was performed in our clinic because of chronic otitis media were included in the study. Mean preoperative air-bone gap of the patients was 32.25 ± 11.85 dB and mean postoperative a...περισσότερα »

Anteriorly Based Galeo-Pericranial Frontalis Flap: A Novel Application in Secondary Rhinoplasty With Atrophic Skin

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Anteriorly Based Galeo-Pericranial Frontalis Flap: A Novel Application in Secondary Rhinoplasty With Atrophic Skin: [image: image] Background: Nasomaxillary dysplasia (Binder syndrome) and cleft are congenital malformations of the midface. Ideally, the nasal deformity is treated from childhood. This approach leads to the need for several surgeries and revisions until full growth is reached. As a result of multiples procedures, the skin over the nasal dorsum sometimes becomes thin, atrophic and could be strongly attached to underlying grafts. For this setting of patients when anothe...περισσότερα »

Bilateral Blindness in a Patient With Temporal Arteritis After Wisdom Tooth Extraction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Bilateral Blindness in a Patient With Temporal Arteritis After Wisdom Tooth Extraction: [image: image] Abstract: A 78-year-old woman reported pain in her right hemiface (middle and upper portions) together with nuchal headache, some days after upper right wisdom tooth extraction. She was treated with nonsteroidal anti-inflammatory drugs by her dentist. Three weeks later, a localized headache over her right superficial temporal artery was reported, and progressive bilateral blindness appeared. A biopsy showed a late stage of temporal arteritis. All the symptoms disappeared following... περισσότερα »

Primary Abbe Flap for Median Cleft Lip Deformity: New Trends on an Old Concept

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Primary Abbe Flap for Median Cleft Lip Deformity: New Trends on an Old Concept: [image: image] Objective: The authors present our experience using primary Abbe flaps for median cleft lip. Methods: The records of 9 patients who underwent primary Abbe flaps were reviewed for indications, operative details, and complications. Flap design is discussed, including the “W” method to facilitate columellar reconstruction. Maxillomandibular fixation was not used. Results: From 2004 to 2015, 9 patients with median cleft lip received primary Abbe flaps. Mean age was 10.2 ± 6.2 months. Lobar h... περισσότερα »

Serial Attacks: Contralateral Hematoma Secondary to Decompressive Craniectomy for Traumatic Brain Injury Led to Posttraumatic Cerebral Infarction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Serial Attacks: Contralateral Hematoma Secondary to Decompressive Craniectomy for Traumatic Brain Injury Led to Posttraumatic Cerebral Infarction: [image: image] Abstract: A 40-year-old man suffered severe brain injury and received left side subdural hematoma evacuation with decompressive craniectomy. Intraoperative brain swelling had occurred during the surgery. Postoperative computed tomography (CT) scan was done immediately and showed a contralateral epidural hematoma resulting in herniation. Secondary hematoma evacuation was performed and found a linear fracture near a bleedin... περισσότερα »

Otoplasty Outcomes With Different Suture Materials

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Otoplasty Outcomes With Different Suture Materials in a Rabbit Model: [image: image] Abstract: Otoplasty is a commonly performed procedure to correct prominent ears. Many different otoplasty techniques have been described but there is no gold standard technique. As well, many different suture materials are used in otoplasty but studies directly comparing different sutures materials are lacking. An otoplasty outcome study with Nylon and Mersilene (2 of the most commonly used sutures in otoplasty) sutures was conducted using a rabbit model. Each rabbit ear was randomized to receive a ...περισσότερα »

Asymmetric Deformity of Maxillofacial Fibrous Dysplasia

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Application of Reverse Engineering Template for the Correction of Asymmetric Deformity of Maxillofacial Fibrous Dysplasia: [image: image] Abstract: Facial asymmetry deformity is the most common symptom of patients with fibrous dysplasia. This study provides a novel method based on computed tomography scan data, mirror-imaged reverse engineering and rapid prototyping for design and manufacture of an individual template guiding accurately the extent and quantity of partial resection of hyperplastic tissues to reshape the affected bones during operation. Ten adult patients with unilat...περισσότερα »

Treatment of Maxillary Glandular Odontogenic Cyst Involving the Same Place of Previously Treated Traumatic Bone Cyst

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Treatment of Maxillary Glandular Odontogenic Cyst Involving the Same Place of Previously Treated Traumatic Bone Cyst: [image: image] Abstract: Glandular odontogenic cyst is a rare developmental odontogenic cysts of the jaws having an aggressive behavior. The most common site of occurrence is the anterior mandible, and it is widely seen in middle-aged people. It is suggested that trauma could be a precipitating factor for its occurrence. This article presents the diagnosis and treatment of a case of glandular odontogenic cyst at anterior maxilla that occurred at the same localizatio... περισσότερα »

Maxillary Reconstruction for Sinus Lift Complications With Oro-Antral Fistula: The Le Fort I Approach

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Maxillary Reconstruction for Sinus Lift Complications With Oro-Antral Fistula: The Le Fort I Approach: [image: image]Abstract: Although sinus lift procedures are reliable, some complications can lead to serious maxillary sequelae, including the development of oro-antral fistula (OAF). Maxillary reconstruction in such patients presents a challenge owing to sinus floor alterations, graft remnants, chronic infection, and morbidity from the original sinus lift approach. The current study describes our technique of maxillary reconstruction using a Le Fort 1 approach following major sinus... περισσότερα »

Evaluation of Volumetric Changes of Augmented Maxillary Sinus With Different Bone Grafting Biomaterials

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Evaluation of Volumetric Changes of Augmented Maxillary Sinus With Different Bone Grafting Biomaterials: [image: image] Abstract Abstract: Extensive alveolar bone resorption because of pneumatized maxillary sinus is a common problem that limits dental implant placement. Maxillary sinus floor augmentation (MSFA) is an accepted treatment protocol that provides sufficient bone volume. The aim of this study was to evaluate the percentage of graft volume reduction following MSFA using cone beam computed tomography. In this retrospective study, cone beam computed tomography scans of MS...περισσότερα »

Prevention of Recurrence in the Surgical Correction of Cryptotia Using Local Flaps With a Cartilage Wedge Graft

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Prevention of Recurrence in the Surgical Correction of Cryptotia Using Local Flaps With a Cartilage Wedge Graft: [image: image]Abstract: Cryptotia attributable to deficient posterior skin coverage frequently recurs. Because local flaps cover only the posterior aspects of the defective upper auricular cartilage and lack functional support to resist collapse of the helix, especially if severe helical cartilage anomalies are present, additional support is required to prevent the postoperative recurrence of this anomaly. The authors present cases of cryptotia treated using local flaps i... περισσότερα »

Adenomatoid Odontogenic Tumor

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Unusual Adenomatoid Odontogenic Tumor: [image: image] Abstract: The adenomatoid odontogenic tumor is a rare benign neoplasm. It can, however, have locally aggressive behavior. This is a case of an adenomatoid odontogenic tumor of unusual location and behavior in a 15-year-old female patient. A panoramic radiograph revealed a large radiolucent lesion involving the retained tooth 33. Teeth involved in this lesion were displaced and with apparent root resorption. A prototype of the mandible showed a marked expansion of cortical bone, fenestration points in the lingual cortex, and frag... περισσότερα »

Improvement of the Marginal Reflex Distance-1 in Blepharoptosis Surgeries

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Improvement of the Marginal Reflex Distance-1 in Blepharoptosis Surgeries: Abstract Abstract: The aim of this study was to predict the improvement of the marginal reflex distance (MRD1) in each blepharoptosis surgery. In PubMed and Scopus, the search terms 1. (blepharoptosis) AND 2. (surgery) AND 3. (levator OR outcome OR MRD OR function OR ptosis amount) were used and 1268 titles were found. Among them 28 papers were analyzed: Aponeurotic surgery (A-group, 8), Muller muscle resection (M-group, 10), Levator resection (L-group, 4), and Frontalis suspension (F-group, 6). The preop-MR...περισσότερα »

Maxillofacial Injuries Occurring After Failed Suicide Attempts Using Long-Barreled Guns

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Our Treatment Approaches in Severe Maxillofacial Injuries Occurring After Failed Suicide Attempts Using Long-Barreled Guns: [image: image] Abstract: Maxillofacial traumas with long-barreled guns may sometimes cause catastrophic results by means of smashing in facial structures. In these patients, reconstruction strategies of both fragmented/lost soft and hard tissues still remain controversial. In their clinic, the authors treated 5 patients with severely injured face after failed suicide attempt between 2008 and 2013. In this study, the authors aimed to present their clinical expe... περισσότερα »

Ischemic Necrosis of Upper Lip, and All Fingers and Toes After Norepinephrine Use

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Ischemic Necrosis of Upper Lip, and All Fingers and Toes After Norepinephrine Use: [image: image]Abstract: A 68-year-old woman with necrosis of total finger, toe, and upper lip was requested by department of internal medicine. She was diagnosed with septic shock and treated with norepinephrine 10 days ago. Norepinephrine is an often-used medicine for normalizing blood pressure in septic shock patients. Norepinephrine stimulates adrenergic receptors, causing vasoconstriction and the rise of blood pressure. These peripheral vasoconstrictions sometimes lead to ischemic changes in end o... περισσότερα »

The Coexistence of Rathke Cleft Cyst and Pituitary Adenoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
The Coexistence of Rathke Cleft Cyst and Pituitary Adenoma: [image: image] Abstract: Both of Pituitary adenoma (PA) and Rathke cleft cyst (RCC) are the most common and benign sellar lesions. Generally, the origin of RCC is considered to be derived from remnants of Rathke punch, while PA is formed by proliferation of the anterior wall of Rathke pouch. Although they have a possibility to share a common embryological origin, the coexistence of PA and RCC is extremely rare. Here, the authors report a 50-year-old male patient who was found to have a large cystic sellar lesion, and surgic... περισσότερα »

Craniosynostosis Following Fetal Methotrexate Exposure

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Craniosynostosis Following Fetal Methotrexate Exposure: Abstract: Methotrexate (MTX) is an antimetabolite, folic acid antagonist that inhibits purine nucleotide production, DNA synthesis, and cellular proliferation. Despite widespread therapeutic uses, MTX remains a potent teratogen. Methotrexate embryopathy encompasses multiorgan system dysfunction, including intrauterine growth restriction as well as cardiac, craniofacial, renal, genital, and skeletal abnormalities. Effects of MTX exposure on fetal development continue to be described. This series of 4 patients with MTX-associated... περισσότερα »

Swiveling a Single Expanded Forehead Flap: A Novel Effective Economical Approach to Total Bilateral Upper and Lower Eyelid Reconstruction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Swiveling a Single Expanded Forehead Flap: A Novel Effective Economical Approach to Total Bilateral Upper and Lower Eyelid Reconstruction: [image: image]Abstract: In our novel approach, a single expanded forehead flap was used to reconstruct bilateral upper and lower eyelids in orbital trauma. A 40-year-old man sustained blast injury resulting in bilateral orbital exenteration and need for bilateral socket and eyelid reconstruction. The sockets were each resurfaced with a temporalis flap. A subgaleal forehead tissue expander was expanded during several weeks until enough tissue was ...περισσότερα »

Combined Intralesional Neodymium-Doped Yttrium Aluminium Garnet Laser and Intratumoral Ligation as Curative Treatment for Craniofacial Arteriovenous Malformations

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Combined Intralesional Neodymium-Doped Yttrium Aluminium Garnet Laser and Intratumoral Ligation as Curative Treatment for Craniofacial Arteriovenous Malformations: [image: image]Abstract: Craniofacial arteriovenous malformation (AVM), although very rare, has been a very difficult problem to treat especially when it is large and involves important structures. Surgical resection often results in unacceptable complications but still not curative. At our institution, treatment by combined intralesional neodymium-doped yttrium aluminium garnet laser and intratumoral ligation has been suc...περισσότερα »

Chyle Leak Following Neck Dissection: Could Radiotherapy Be Considered a Management Option?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 30 δευτερόλεπτα
Chyle Leak Following Neck Dissection: Could Radiotherapy Be Considered a Management Option?: [image: image]Abstract: Chyle leak after neck dissection is a relatively rare complication in head and neck cancer scenario. This review summarizes the basic knowledge of chyle leak underlying the potential benefit induced by low-dose radiation therapy and may serve as basis for future studies, necessary to optimize chyle leak management in head and neck cancer patients.

Influence of pesticide physicochemical properties on the association between plasma and hair concentration

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 38 δευτερόλεπτα
Abstract Although the relationship between chemical intake and resulting concentration in hair remains incompletely elucidated, the transfer from blood to hair bulb living cells is generally considered the main route of incorporation. The present work investigated the correlation between blood and hair concentration of 23 pesticides/metabolites from different chemical classes in rats submitted to chronic controlled exposure. *Long-Evans* rats were administered pesticides by gavage three times per week over a 90-day period. After hair sample decontamination, pulverization, and extra...περισσότερα »

High precision attachment of silver nanoparticles on AFM tips by dielectrophoresis

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 38 δευτερόλεπτα
Abstract AFM tips are modified with silver nanoparticles using an AC electrical field. The used technique works with sub-micron precision and also does not require chemical modification of the tip. Based on the electrical parameters applied in the process, particle density and particle position on the apex of the tip can be adjusted. The feasibility of the method is proven by subsequent tip-enhanced Raman spectroscopy (TERS) measurements using the fabricated tips as a measurement probe. Since this modification process itself does not require any lithographic processing, the techniq...περισσότερα »

Determining the Median Sagittal Plane of Three-Dimensional Facial Data

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Comparison Between Interactive Closest Point and Procrustes Analysis for Determining the Median Sagittal Plane of Three-Dimensional Facial Data: [image: image]Objective: To compare 2 digital methods to determine median sagittal plane of three-dimensional facial data—the interactive closest point algorithm and Procrustes analysis. Methods: The three-dimensional facial data of the 30 volunteers were got by the Face Scan 3D optical sensor (3D-Shape GmbH, Erlangen, Germany), and then were input to the reverse engineering software Imageware 13.0 (Siemens, Plano, TX) and Geomagic 2012 (Ca... περισσότερα »

Alveolar Bone, Upper Lip and Columellar Reconstruction With Composite Abbe Flap

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Alveolar Bone, Upper Lip and Columellar Reconstruction With Composite Abbe Flap: [image: image]Abstract: Bilateral cleft lip and palate repair usually requires secondary corrective intentions. Abbe flap is a useful option and has many modifications for revision surgeries of cleft lip nose deformities. Study evaluated a 23-year-old woman for secondary cleft lip nose correction. The authors performed a composite Abbe flap, which included mental bone for repairing the upper lip harmony, maintaining the columellar elongation and bridging central alveolar bone cleft. No complications wer...περισσότερα »

The Extended Subfrontal and Fronto-Orbito-Zygomatic Approach in Skull Base Meningioma Surgery: Clinical, Radiologic, and Cosmetic Outcome

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
The Extended Subfrontal and Fronto-Orbito-Zygomatic Approach in Skull Base Meningioma Surgery: Clinical, Radiologic, and Cosmetic Outcome: [image: image] Objective: To review the outcome and cosmetic results of patients undergoing extended subfrontal and fronto-orbito-zygomatic craniotomy for resection of skull base meningiomas. Methods: All surgeries were performed in cooperation with an oral and maxillofacial surgeon between 2006 and 2012. Clinical presentation, surgical techniques and complications, cosmetic, clinical, and radiologic outcomes are presented. Results: This study ...περισσότερα »

Allergic Contact Dermatitis After Bone-anchored Hearing Aid Surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Allergic Contact Dermatitis After Bone-anchored Hearing Aid Surgery: [image: image]

Dumbbell-Shaped Recurrent Skin Cancer in the Temple Area

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Dumbbell-Shaped Recurrent Skin Cancer in the Temple Area: [image: image]

Aesthetic Unit-Based Reconstruction of Periorbital Defects

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Aesthetic Unit-Based Reconstruction of Periorbital Defects: [image: image] Purpose: The aim of this study was to perform a retrospective analysis of patients who underwent periorbital area reconstructions, determine their sociodemographic characteristics, analyze the effects of defect etiologies and locations classified according to periorbital subunits on our reconstruction options, and to present our treatment outcomes and clinical experience. Methods: A retrospective chart review of 23 patients operated in our department between January 2010 and March 2013 and underwent periorbi...περισσότερα »

Postoperative Complications in Craniomaxillofacial Reconstruction With Medpor

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Postoperative Complications in Craniomaxillofacial Reconstruction With Medpor: Abstract: Bone reconstruction in craniofacial surgery is a challenge for surgeons, who most commonly adopt the autogenous bone grafting and alloplastic implants in such procedures. Among the alloplastic materials, the high-density porous polyethylene is highlighted—Medpor (Medpor, Porex Surgical Inc, Newman, GA), considered to be pure polyethylene, with only 1 manufacturing process and standard pore size. The purpose of the current study has been to present through a review of literature and the types of ...περισσότερα »

Assessment of Patient Satisfaction With Evaluation Methods in Open Technique Septorhinoplasty

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Assessment of Patient Satisfaction With Evaluation Methods in Open Technique Septorhinoplasty: Abstract: The aim of this study was to measure the postoperative satisfaction of patients who underwent open technique septorhinoplasty (SRP) using Nasal Obstruction Symptoms Evaluation (NOSE), Rhinoplasty Outcomes Evaluation (ROE) and visual analog scale (VAS), and to assess the reliability and usability of these forms in the outcome of SRP. Forty-five patients who underwent primary open technique SRP were included in the study. The levels of patient satisfaction were assessed before the...περισσότερα »

Scalp Dermatofibrosarcoma Protuberans: A Potential Diagnostic Pitfall

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Scalp Dermatofibrosarcoma Protuberans: A Potential Diagnostic Pitfall: [image: image]No abstract available

The Modified Technique of External Dacryocystorhinostomy in the Management of Complicated Nasolacrimal Duct Obstruction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
The Modified Technique of External Dacryocystorhinostomy in the Management of Complicated Nasolacrimal Duct Obstruction: [image: image] Aim: To evaluate the outcome of the modified technique of external dacryocystorhinostomy (EDCR) with a “U”-shaped single flap that was fixed on to the orbicularis muscle with combined silicone tube in dacriostenosis. In cases with decreased visibility because of excessive bleeding during surgery, a small sac size, and difficulty of mutual suturing between nasal mucosal and sac flaps related to distance. Methods: This retrospective study included 11... περισσότερα »

Importance of Imaging Examinations to Planning the Removal of a Foreign Body From the Tongue

στοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα
Importance of Imaging Examinations to Planning the Removal of a Foreign Body From the Tongue: [image: image] <img src="data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAg8AAAKiCAYAAABRpz+SAAAgAElEQVR4XuzdB7xvV1Un8JO8vLy0l95J7wFCaGJD7NhRdIqjgoI6yojojDpFnRn72LtOscxYKPaOUgQpivSSQhISQiBASCU97+Ulmf1d5/zu2++8/y2vJZR73ud97r3//zn77L322mv9Vtlr7/dQu4ZPgMsg9mv/5z8/AYa2PoR1CqxTYJ0C6xRYp8DHFAX2e0TAw57AFQhhAgk9JR9sf+zf/s9/fkxRe+rMNISPxa59XPRpT9jHAPeY/o94Bz4upmm9k+sUWKfAJzAFPm7BQ+ZkrXJ8rjCW81Ts688/gXnpYR3a7s7TXunkWpluuZftMXrZK6NYb2SdAusUWKfAblPgkQEPu93d6cFeeK9VEM8F/qIYx+5qpF19bk/Hv/78SIFdpXvu30X6LWKdX...περισσότερα »

Interhemispheric inhibition is dynamically regulated during action observation

Publication date: Available online 10 March 2016 Source:Cortex Author(s): Nicolas Gueugneau, Marco Bove, Yves Ballay, Charalambos Papaxanthis It is now well established that the motor system plays a pivotal role in action observation and that the neurophysiological processes underlying perception and action overlaps. However, while various experiments have shown a specific facilitation of the contralateral […]

Temporal alignment of pupillary response with stimulus events via deconvolutiona)

Analysis of pupil dilation has been used as an index of attentional effort in the auditory domain. Previous work has modeled the pupillary response to attentional effort as a linear time-invariant system with a characteristic impulse response, and used deconvolution to estimate the attentional effort that gives rise to changes in pupil size. Here it […]

Targeting Retinoid Receptors to Treat Schizophrenia: Rationale and Progress to Date

Abstract This review provides the rationale and reports on the progress to date regarding the targeting of retinoid receptors for the treatment of schizophrenia and schizoaffective disorder and the role of retinoic acid in functions of the normal brain, and in psychotic states. After a brief introduction, we describe the normal function of retinoic acid […]

Impaired Tilt Suppression of Post-Rotatory Nystagmus and Cross-Coupled Head-Shaking Nystagmus in Cerebellar Lesions: Image Mapping Study

Abstract We sought to determine the cerebellar structures responsible for tilt suppression of post-rotatory nystagmus. We investigated ocular motor findings and MRI lesions in 73 patients with isolated cerebellar lesions who underwent recording of the vestibulo-ocular reflex (VOR) using rotatory chair tests. Tilt suppression of post-rotatory nystagmus was diminished in 27 patients (27/73, 37.0 %). […]

Genetic Targeting in Cerebellar Purkinje Cells: an Update

Abstract Since the last review paper published in Cerebellum in 2002 [1], there has been a substantial increase in the number of experiments utilizing transgenic manipulations in murine cerebellar Purkinje cells. Most of these approaches were made possible with the use of the Cre/loxP methodology and pcp2/L7 based Cre recombinase expressing transgenic mouse strains. This […]

Er:Yag Laser Treatment of Simple Snorers in an Outpatient Setting

Objective: Snoring occurs as a result of soft tissue vibration caused by a partial upper airway collapse during sleep. This study evaluated the effectiveness and potential adverse side effects associated with the use of a nonsurgical, erbium-doped yttrium aluminum garnet (Er:YAG) laser treatment for patients with snoring conditions. Materials and Methods: In total, 33 patients […]

Rhinosinusal Inflammation and High Mobility Group Box 1 Protein: A New Target for Therapy

Background/Aims: High mobility group box 1 (HMGB1) is a protein belonging to the class of damage-associated molecular pattern molecules, which activates innate immunity and powerful inflammatory factors. The aim of this review is to show the importance of HMGB1 in the pathogenesis of nasal inflammatory diseases and to suggest that inhibition of HMGB1 may be […]

Cost Implications for Subsequent Perinatal Outcomes After IVF Stratified by Number of Embryos Transferred: A Five Year Analysis of Vermont Data

Abstract Background In states in the USA without in vitro fertilzation coverage (IVF) insurance coverage, more embryos are transferred per cycle leading to higher risks of multi-fetal pregnancies and adverse pregnancy outcomes. Objective To determine frequency and cost of selected adverse perinatal complications based on number of embryos transferred during IVF, and calculate incremental cost […]

Tumeurs neuroendocrines pancréatiques

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1MbBMZp via IFTTT

Topical Retinoids: Therapeutic Mechanisms in the Treatment of Photodamaged Skin

Abstract Retinoids are a group of substances comprising vitamin A and its natural and synthetic derivatives. Retinoids were first used in dermatology in 1943 by Straumfjord for acne vulgaris. Since that time, retinoids have been utilized in the management and treatment of various skin conditions, including photoaging. Photodamage of the skin occurs as a consequence […]

Outcomes, Data, and Indicators of Violence at the Community Level

Abstract Youth violence is a major problem in the United States. It remains the third leading cause of death among youth between the ages of 10 and 24 years and the leading cause of death in Blacks between 10 and 24 years of age. In its effort to prevent youth violence, the Center for Disease […]

Community Engagement in Youth Violence Prevention: Crafting Methods to Context

Abstract The purpose of the Youth Violence Prevention Centers (YVPC) Program at the Centers for Disease Control and Prevention is to reduce youth violence in defined high-risk communities through the implementation and evaluation of comprehensive, evidence based prevention strategies. Within this common framework, each YVPC varies in its structure and methods, however all engage communities […]

easySTORM: a robust, lower-cost approach to localisation and TIRF microscopy

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
TIRF and STORM microscopy are super-resolving fluorescence imaging modalities for which current implementations on standard microscopes can present significant complexity and cost. We present a straightforward and low-cost approach to implement STORM and TIRF taking advantage of multimode optical fibres and multimode diode lasers to provide the required excitation light. Combined with open source software… Continue reading easySTORM: a robust, lower-cost approach to localisation and TIRF microscopy

Organic pollution of the Büyük Menderes River, Turkey and effects on aquaculture

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Water quality was measured at eight stations on the Buyuk Menderes River in Turkey (Adıgüzel dam, Yenice regülator, Sarayköy bridge, Feslek regülator, Yenipazar bridge, Aydın bridge, Koçarlı bridge, Söke regülator) between 2000 and 2013 in February, April, June, August, October and December. The resulting data were evaluated in terms of biochemical oxygen demand (BOD),… Continue reading Organic pollution of the Büyük Menderes River, Turkey and effects on aquaculture

Er:Yag Laser Treatment of Simple Snorers in an Outpatient Setting

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Objective: Snoring occurs as a result of soft tissue vibration caused by a partial upper airway collapse during sleep. This study evaluated the effectiveness and potential adverse side effects associated with the use of a nonsurgical, erbium-doped yttrium aluminum garnet (Er:YAG) laser treatment for patients with snoring conditions. Materials and Methods: In total, 33 patients… Continue reading Er:Yag Laser Treatment of Simple Snorers in an Outpatient Setting

Atypical Carcinoid Tumor and Chondroid and Glandular Hamartoma of the Arythenoid Region

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Atypical Carcinoid Tumor and Chondroid and Glandular Hamartoma of the Arythenoid Region: Abstract: Neuroendocrine tumors of the head and neck are rare. Laryngeal hamartomas are even rarer especially in adult patients. Here in a 69-year-old male patient is presented who had atypical carcinoid tumor and chondroid and glandular hamartoma of the medial mucosa of the… Continue reading Atypical Carcinoid Tumor and Chondroid and Glandular Hamartoma of the Arythenoid Region

Rhinosinusal Inflammation and High Mobility Group Box 1 Protein: A New Target for Therapy

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Background/Aims: High mobility group box 1 (HMGB1) is a protein belonging to the class of damage-associated molecular pattern molecules, which activates innate immunity and powerful inflammatory factors. The aim of this review is to show the importance of HMGB1 in the pathogenesis of nasal inflammatory diseases and to suggest that inhibition of HMGB1 may be… Continue reading Rhinosinusal Inflammation and High Mobility Group Box 1 Protein: A New Target for Therapy

Reconstruction of Extended Orbitomaxillectomy and Hemimandibulectomy Defects With Fibula Flaps and Patient-Specific Implants

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Reconstruction of Extended Orbitomaxillectomy and Hemimandibulectomy Defects With Fibula Flaps and Patient-Specific Implants: Abstract: An extended orbitomaxillectomy and hemimandibulectomy for polyostotic juvenile ossifying fibroma resection were performed with the assistance of patient-specific cutting guides. The resulting defects were reconstructed in stages. First, a patient-specific mandibular reconstruction plate was fixed to the hemimandibulectomy defect in the… Continue reading Reconstruction of Extended Orbitomaxillectomy and Hemimandibulectomy Defects With Fibula Flaps an... περισσότερα »

Cost Implications for Subsequent Perinatal Outcomes After IVF Stratified by Number of Embryos Transferred: A Five Year Analysis of Vermont Data

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Background In states in the USA without in vitro fertilzation coverage (IVF) insurance coverage, more embryos are transferred per cycle leading to higher risks of multi-fetal pregnancies and adverse pregnancy outcomes. Objective To determine frequency and cost of selected adverse perinatal complications based on number of embryos transferred during IVF, and calculate incremental cost… Continue reading Cost Implications for Subsequent Perinatal Outcomes After IVF Stratified by Number of Embryos Transferred: A Five Year Analysis of Vermont Data

Tumeurs neuroendocrines pancréatiques

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1MbBMZp via IFTTT

Nasopharyngeal Teratoma Arising From the Vomer

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
A Rare Nasopharyngeal Teratoma Arising From the Vomer: Abstract: Teratomas are rare germ cell neoplasms derived from the 3 germinal layers (ectoderm, mesoderm, and endoderm). Nasopharyngeal teratoma is a very rare teratoma arising anywhere from the oronasal cavity, regarded as an expanding, avity filling lesion, with a high mortality rate because of severe airway obstruction,… Continue reading Nasopharyngeal Teratoma Arising From the Vomer

Topical Retinoids: Therapeutic Mechanisms in the Treatment of Photodamaged Skin

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Retinoids are a group of substances comprising vitamin A and its natural and synthetic derivatives. Retinoids were first used in dermatology in 1943 by Straumfjord for acne vulgaris. Since that time, retinoids have been utilized in the management and treatment of various skin conditions, including photoaging. Photodamage of the skin occurs as a consequence… Continue reading Topical Retinoids: Therapeutic Mechanisms in the Treatment of Photodamaged Skin

Comparison of Intracranial Volume and Cephalic Index After Correction of Sagittal Synostosis With Spring-assisted Surgery or Pi-plasty

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Comparison of Intracranial Volume and Cephalic Index After Correction of Sagittal Synostosis With Spring-assisted Surgery or Pi-plasty: [image: image]Background: The aim of the current study was to determine the intracranial volume (ICV) and cephalic index (CI) in patients operated for sagittal synostosis, and to compare the outcome of 2 different surgical techniques: craniotomy combined with springs and modified pi-plasty. Methods: The authors studied all patients who had been operated for isolated sagittal synostosis and registered in the Gothenburg Craniofacial Registry until the...περισσότερα »

Curative Transvenous Onyx Embolization of a Maxillary Arteriovenous Malformation in a Child: Report of a New Technique

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Curative Transvenous Onyx Embolization of a Maxillary Arteriovenous Malformation in a Child: Report of a New Technique: [image: image]Abstract: Endovascular management of maxillary arteriovenous malformation (AVMs) can be complex. Transarterial, transvenous, and direct puncture embolization has been described. The authors report the case of a 9-year-old girl with a hemorrhagic maxillary AVM, which has been treated by transvenous embolization after failure of transarterial embolization. The venous pouch was catheterized with a detachable tip microcatheter and occluded by slow Onyx in...περισσότερα »

Correlation Between Cephalometric Measures and End-of-Treatment Facial Attractiveness

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Correlation Between Cephalometric Measures and End-of-Treatment Facial Attractiveness: [image: Collapse Box]Abstract Abstract: Sixty-nine experienced Chinese orthodontists evaluated 108 Chinese patients’ facial attractiveness from set of photographs (frontal, lateral, and frontal smiling photos) taken at the end of orthodontic treatment. These 108 patients, which contained an equal number of patients with Class I, II, and III malocclusion, were randomly selected from 6 orthodontic treatment centers throughout China. Spearman rank-order correlation coefficients (*r*s) analyses wer... περισσότερα »

Computed Tomography Imaging Measurement for Safer Cavernous Sinus Biopsy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Computed Tomography Imaging Measurement for Safer Cavernous Sinus Biopsy: [image: image] Abstract: The aim of this study was to measure the relative location between foramen ovale and internal carotid artery. The results can guide surgeons to avoid damaging internal carotid artery in cavernous sinus biopsy. One hundred twenty people (73 men and 47 women) were involved in this study anonymously. Five parameters of both sides were measured on 2 planes. This study provides data for safer cavernous sinus biopsy.

Does Freeze–Thawing Influence the Effects of Platelet Concentrates? An In Vitro Study on Human Adipose-Derived Stem Cells

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Does Freeze–Thawing Influence the Effects of Platelet Concentrates? An In Vitro Study on Human Adipose-Derived Stem Cells: [image: image]Abstract: Human adipose-derived stem cells (hASCs) have been proposed as a possible therapy for tissue regeneration in aesthetic, plastic, and reconstructive surgery. Today, platelet concentrates are used in a wide range of disciplines, but their storage has become a controversial aspect. The purpose of this in vitro study was to evaluate the effect of plasma rich in growth factors (PRGF), after a freeze–thawing cycle, on the proliferation and biol... περισσότερα »

Hemangioma of the Zygomatic Bone

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Hemangioma of the Zygomatic Bone: [image: image]Abstract: Benign masses arising from facial bones have been reported several times in the literature. Hemangiomas are one of the uncommon benign tumors. In this study, the authors aimed to present a rare patient of zygomatic intraosseos hemangioma and their management. A 40-year-old woman with a mass in her left lateral cantus admitted to our clinic. Preoperative computed tomography and magnetic resonance imaging revealed an osseos mass in her left zygoma. The authors conclude that it should be kept in mind that although they are very ...περισσότερα »

Assessment of Stability of Craniofacial Implants by Resonant Frequency Analysis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Assessment of Stability of Craniofacial Implants by Resonant Frequency Analysis: Abstract: Implant stability is a principal precondition for the success of implant therapy. Extraoral implants (EO) are mainly used for anchoring of maxillofacial epithesis. However, assessment of implant stability is mostly based on principles derived from oral implants. The aim of this study was to investigate clinical stability of EO craniofacial disk implants (single, double, and triple) by resonance frequency analysis at different stages of the bone's healing. Twenty patients with orbital (11), nas... περισσότερα »

Risk Factors for Life-Threatening Complications of Maxillofacial Space Infection

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Risk Factors for Life-Threatening Complications of Maxillofacial Space Infection: [image: image]Abstract: The purpose of this study was to review the clinical features of maxillofacial space infection (MSI), and to identify the potential risk factors predisposing to life-threatening complications. A retrospective review of the medical charts of patients with MSI treated at Peking University School and Hospital of Stomatology from August 2008 to September 2013 was conducted. A total of 127 patients [75 men (59.1%) and 52 women (40.9%); mean age, 45.39 ± 21.18 years, with a range of 1... περισσότερα »

Atypical Carcinoid Tumor and Chondroid and Glandular Hamartoma of the Arythenoid Region

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Atypical Carcinoid Tumor and Chondroid and Glandular Hamartoma of the Arythenoid Region: [image: image] Abstract: Neuroendocrine tumors of the head and neck are rare. Laryngeal hamartomas are even rarer especially in adult patients. Here in a 69-year-old male patient is presented who had atypical carcinoid tumor and chondroid and glandular hamartoma of the medial mucosa of the left arythenoid. To the best of our knowledge, this is the first case presenting the association of these 2 rare lesions.

Reconstruction of Extended Orbitomaxillectomy and Hemimandibulectomy Defects With Fibula Flaps and Patient-Specific Implants

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Reconstruction of Extended Orbitomaxillectomy and Hemimandibulectomy Defects With Fibula Flaps and Patient-Specific Implants: [image: image] Abstract: An extended orbitomaxillectomy and hemimandibulectomy for polyostotic juvenile ossifying fibroma resection were performed with the assistance of patient-specific cutting guides. The resulting defects were reconstructed in stages. First, a patient-specific mandibular reconstruction plate was fixed to the hemimandibulectomy defect in the same operation as the resection. After margins were proven to be free of tumor on histologic analys...περισσότερα »

Nasopharyngeal Teratoma Arising From the Vomer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
A Rare Nasopharyngeal Teratoma Arising From the Vomer: [image: image] Abstract: Teratomas are rare germ cell neoplasms derived from the 3 germinal layers (ectoderm, mesoderm, and endoderm). Nasopharyngeal teratoma is a very rare teratoma arising anywhere from the oronasal cavity, regarded as an expanding, avity filling lesion, with a high mortality rate because of severe airway obstruction, especially in the neonatal period and make up only 2% of all teratomas. The authors present a case of an infant girl with a single, finger-like, hairy teratoma arising from the vomer and protrudi...περισσότερα »

The Efficacy and Safety of Tranexamic Acid in Cranio-Maxillofacial and Plastic Surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
The Efficacy and Safety of Tranexamic Acid in Cranio-Maxillofacial and Plastic Surgery: [image: image] Abstract: The antifibrinolytic drug tranexamic acid (TXA) is effective in reducing blood loss and transfusion requirements in other fields of elective surgery and its use is emerging in a number of plastic surgical subspecialties. This systematic review and meta-analysis evaluates the current evidence for the efficacy and safety of TXA in craniomaxillofacial, head and neck, breast, aesthetic, burns, and reconstructive microsurgery. We searched PubMed, EMBASE, Medline, The Cochrane...περισσότερα »

The Odorant Receptor-Dependent Role of Olfactory Marker Protein in Olfactory Receptor Neurons.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
*The Odorant Receptor-Dependent Role of Olfactory Marker Protein in Olfactory Receptor Neurons.* J Neurosci. 2016 Mar 9;36(10):2995-3006 Authors: Dibattista M, Reisert J Abstract UNLABELLED: Olfactory receptor neurons (ORNs) in the nasal cavity detect and transduce odorants into action potentials to be conveyed to the olfactory bulb. Odorants are delivered to ORNs via the inhaled air at breathing frequencies that can vary from 2 to 10 Hz in the mouse. Thus olfactory transduction should occur at sufficient speed such that it can accommodate repetitive and frequent stimulation. Act...περισσότερα »

CALHM1 Deletion in Mice Affects Glossopharyngeal Taste Responses, Food Intake, Body Weight, and Life Span.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *CALHM1 Deletion in Mice Affects Glossopharyngeal Taste Responses, Food Intake, Body Weight, and Life Span.* Chem Senses. 2015 Jul;40(6):373-9 Authors: Hellekant G, Schmolling J, Marambaud P, Rose-Hellekant TA Abstract Stimulation of Type II taste receptor cells (TRCs) with T1R taste receptors causes sweet or umami taste, whereas T2Rs elicit bitter taste. Type II TRCs contain the calcium channel, calcium homeostasis modulator protein 1 (CALHM1), which releases adenosine triphosphate (ATP) transmitter to taste fiber... περισσότερα »

The Odorant Receptor-Dependent Role of Olfactory Marker Protein in Olfactory Receptor Neurons.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
*The Odorant Receptor-Dependent Role of Olfactory Marker Protein in Olfactory Receptor Neurons.* J Neurosci. 2016 Mar 9;36(10):2995-3006 Authors: Dibattista M, Reisert J Abstract UNLABELLED: Olfactory receptor neurons (ORNs) in the nasal cavity detect and transduce odorants into action potentials to be conveyed to the olfactory bulb. Odorants are delivered to ORNs via the inhaled air at breathing frequencies that can vary from 2 to 10 Hz in the mouse. Thus olfactory transduction should occur at sufficient speed such that it can accommodate repetitive and frequent stimulation. Act...περισσότερα »

Quinine Bitterness and Grapefruit Liking Associate with Allelic Variants in TAS2R31.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Quinine Bitterness and Grapefruit Liking Associate with Allelic Variants in TAS2R31.* Chem Senses. 2015 Jul;40(6):437-43 Authors: Hayes JE, Feeney EL, Nolden AA, McGeary JE Abstract Multiple psychophysical gene-association studies suggest a single nucleotide polymorphism (SNP) within the bitter receptor gene TAS2R19 on chromosome 12 may be functional. Previously, the Arg299Cys SNP (rs10772420) has been associated with differential bitterness of quinine and differential liking for grapefruit juice. However, quinine... περισσότερα »

Variability in Human Bitter Taste Sensitivity to Chemically Diverse Compounds Can Be Accounted for by Differential TAS2R Activation.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Variability in Human Bitter Taste Sensitivity to Chemically Diverse Compounds Can Be Accounted for by Differential TAS2R Activation.* Chem Senses. 2015 Jul;40(6):427-35 Authors: Roura E, Aldayyani A, Thavaraj P, Prakash S, Greenway D, Thomas WG, Meyerhof W, Roudnitzky N, Foster SR Abstract The human population displays high variation in taste perception. Differences in individual taste sensitivity may also impact on nutrient intake and overall appetite. A well-characterized example is the variable perception of bi... περισσότερα »

Temperature Affects Human Sweet Taste via At Least Two Mechanisms.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Temperature Affects Human Sweet Taste via At Least Two Mechanisms.* Chem Senses. 2015 Jul;40(6):391-9 Authors: Green BG, Nachtigal D Abstract The reported effects of temperature on sweet taste in humans have generally been small and inconsistent. Here, we describe 3 experiments that follow up a recent finding that cooling from 37 to 21 °C does not reduce the initial sweetness of sucrose but increases sweet taste adaptation. In experiment 1, subjects rated the sweetness of sucrose, glucose, and fructose solutions at... περισσότερα »

Regulatory Effects of Ca2+ and H+ on the Rat Chorda Tympani Response to NaCl and KCl.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Regulatory Effects of Ca2+ and H+ on the Rat Chorda Tympani Response to NaCl and KCl.* Chem Senses. 2015 Jul;40(6):401-12 Authors: DeSimone JA, Phan TH, Mummalaneni S, Rhyu MR, Heck GL, Lyall V Abstract Modulatory effects of pHi and [Ca(2+)]i on taste receptor cell (TRC) epithelial sodium channel (ENaC) were investigated by monitoring chorda tympani (CT) responses to NaCl and KCl at various lingual voltages, before and after lingual application of ionomycin and with 0-10mM CaCl2 in the stimulus and rinse solutions... περισσότερα »

A Binary Genetic Approach to Characterize TRPM5 Cells in Mice.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *A Binary Genetic Approach to Characterize TRPM5 Cells in Mice.* Chem Senses. 2015 Jul;40(6):413-25 Authors: Kusumakshi S, Voigt A, Hübner S, Hermans-Borgmeyer I, Ortalli A, Pyrski M, Dörr J, Zufall F, Flockerzi V, Meyerhof W, Montmayeur JP, Boehm U Abstract Transient receptor potential channel subfamily M member 5 (TRPM5) is an important downstream signaling component in a subset of taste receptor cells making it a potential target for taste modulation. Interestingly, TRPM5 has been detected in extra-oral tissues; ... περισσότερα »

Characterization of Sensory Properties of Flavanols - A Molecular Dynamic Approach.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Characterization of Sensory Properties of Flavanols - A Molecular Dynamic Approach.* Chem Senses. 2015 Jul;40(6):381-90 Authors: Ferrer-Gallego R, Quijada-Morín N, Brás NF, Gomes P, de Freitas V, Rivas-Gonzalo JC, Escribano-Bailón MT Abstract In this work, sensations elicited by catechin and procyanidins in comparison with those elicited by gallocatechin and prodelphinidins were evaluated by means of a sensory panel. To obtain further insights into the mechanisms of action, molecular dynamics (MD) simulations and ... περισσότερα »

CALHM1 Deletion in Mice Affects Glossopharyngeal Taste Responses, Food Intake, Body Weight, and Life Span.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *CALHM1 Deletion in Mice Affects Glossopharyngeal Taste Responses, Food Intake, Body Weight, and Life Span.* Chem Senses. 2015 Jul;40(6):373-9 Authors: Hellekant G, Schmolling J, Marambaud P, Rose-Hellekant TA Abstract Stimulation of Type II taste receptor cells (TRCs) with T1R taste receptors causes sweet or umami taste, whereas T2Rs elicit bitter taste. Type II TRCs contain the calcium channel, calcium homeostasis modulator protein 1 (CALHM1), which releases adenosine triphosphate (ATP) transmitter to taste fiber... περισσότερα »

The Odorant Receptor-Dependent Role of Olfactory Marker Protein in Olfactory Receptor Neurons.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
*The Odorant Receptor-Dependent Role of Olfactory Marker Protein in Olfactory Receptor Neurons.* J Neurosci. 2016 Mar 9;36(10):2995-3006 Authors: Dibattista M, Reisert J Abstract UNLABELLED: Olfactory receptor neurons (ORNs) in the nasal cavity detect and transduce odorants into action potentials to be conveyed to the olfactory bulb. Odorants are delivered to ORNs via the inhaled air at breathing frequencies that can vary from 2 to 10 Hz in the mouse. Thus olfactory transduction should occur at sufficient speed such that it can accommodate repetitive and frequent stimulation. Act...περισσότερα »

Quinine Bitterness and Grapefruit Liking Associate with Allelic Variants in TAS2R31.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Quinine Bitterness and Grapefruit Liking Associate with Allelic Variants in TAS2R31.* Chem Senses. 2015 Jul;40(6):437-43 Authors: Hayes JE, Feeney EL, Nolden AA, McGeary JE Abstract Multiple psychophysical gene-association studies suggest a single nucleotide polymorphism (SNP) within the bitter receptor gene TAS2R19 on chromosome 12 may be functional. Previously, the Arg299Cys SNP (rs10772420) has been associated with differential bitterness of quinine and differential liking for grapefruit juice. However, quinine... περισσότερα »

Variability in Human Bitter Taste Sensitivity to Chemically Diverse Compounds Can Be Accounted for by Differential TAS2R Activation.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Variability in Human Bitter Taste Sensitivity to Chemically Diverse Compounds Can Be Accounted for by Differential TAS2R Activation.* Chem Senses. 2015 Jul;40(6):427-35 Authors: Roura E, Aldayyani A, Thavaraj P, Prakash S, Greenway D, Thomas WG, Meyerhof W, Roudnitzky N, Foster SR Abstract The human population displays high variation in taste perception. Differences in individual taste sensitivity may also impact on nutrient intake and overall appetite. A well-characterized example is the variable perception of bi... περισσότερα »

Temperature Affects Human Sweet Taste via At Least Two Mechanisms.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Temperature Affects Human Sweet Taste via At Least Two Mechanisms.* Chem Senses. 2015 Jul;40(6):391-9 Authors: Green BG, Nachtigal D Abstract The reported effects of temperature on sweet taste in humans have generally been small and inconsistent. Here, we describe 3 experiments that follow up a recent finding that cooling from 37 to 21 °C does not reduce the initial sweetness of sucrose but increases sweet taste adaptation. In experiment 1, subjects rated the sweetness of sucrose, glucose, and fructose solutions at... περισσότερα »

Regulatory Effects of Ca2+ and H+ on the Rat Chorda Tympani Response to NaCl and KCl.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Regulatory Effects of Ca2+ and H+ on the Rat Chorda Tympani Response to NaCl and KCl.* Chem Senses. 2015 Jul;40(6):401-12 Authors: DeSimone JA, Phan TH, Mummalaneni S, Rhyu MR, Heck GL, Lyall V Abstract Modulatory effects of pHi and [Ca(2+)]i on taste receptor cell (TRC) epithelial sodium channel (ENaC) were investigated by monitoring chorda tympani (CT) responses to NaCl and KCl at various lingual voltages, before and after lingual application of ionomycin and with 0-10mM CaCl2 in the stimulus and rinse solutions... περισσότερα »

A Binary Genetic Approach to Characterize TRPM5 Cells in Mice.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *A Binary Genetic Approach to Characterize TRPM5 Cells in Mice.* Chem Senses. 2015 Jul;40(6):413-25 Authors: Kusumakshi S, Voigt A, Hübner S, Hermans-Borgmeyer I, Ortalli A, Pyrski M, Dörr J, Zufall F, Flockerzi V, Meyerhof W, Montmayeur JP, Boehm U Abstract Transient receptor potential channel subfamily M member 5 (TRPM5) is an important downstream signaling component in a subset of taste receptor cells making it a potential target for taste modulation. Interestingly, TRPM5 has been detected in extra-oral tissues; ... περισσότερα »

Characterization of Sensory Properties of Flavanols - A Molecular Dynamic Approach.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Characterization of Sensory Properties of Flavanols - A Molecular Dynamic Approach.* Chem Senses. 2015 Jul;40(6):381-90 Authors: Ferrer-Gallego R, Quijada-Morín N, Brás NF, Gomes P, de Freitas V, Rivas-Gonzalo JC, Escribano-Bailón MT Abstract In this work, sensations elicited by catechin and procyanidins in comparison with those elicited by gallocatechin and prodelphinidins were evaluated by means of a sensory panel. To obtain further insights into the mechanisms of action, molecular dynamics (MD) simulations and ... περισσότερα »

CALHM1 Deletion in Mice Affects Glossopharyngeal Taste Responses, Food Intake, Body Weight, and Life Span.

Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *CALHM1 Deletion in Mice Affects Glossopharyngeal Taste Responses, Food Intake, Body Weight, and Life Span.* Chem Senses. 2015 Jul;40(6):373-9 Authors: Hellekant G, Schmolling J, Marambaud P, Rose-Hellekant TA Abstract Stimulation of Type II taste receptor cells (TRCs) with T1R taste receptors causes sweet or umami taste, whereas T2Rs elicit bitter taste. Type II TRCs contain the calcium channel, calcium homeostasis modulator protein 1 (CALHM1), which releases adenosine triphosphate (ATP) transmitter to taste fiber... περισσότερα »

Endoscopic Versus Microscopic Approach in Pituitary Surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Endoscopic Versus Microscopic Approach in Pituitary Surgery: [image: image] Abstract: The objective of this study is to compare the efficacy and complications of endoscopic and microscopic transsphenoidal surgery in the treatment of pituitary adenomas. A total of 105 follow-up cases including 60 in endoscopic surgery and 45 in microscopic surgery were treated in our hospital between January 2012 and November 2014. The endoscopic approach had a higher rate of gross tumor removal (81.7% versus 62.2%, P 0.05). The length of the operation was longer (175 ± 25 minutes versus 110 ± 17 mi... περισσότερα »

Real Time Navigation-Assisted Orbital Wall Reconstruction in Blowout Fractures

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Real Time Navigation-Assisted Orbital Wall Reconstruction in Blowout Fractures: [image: image] Background: Limitation in performing restoration of orbital structures is the narrow, deep, and dark surgical field, which makes it difficult to view the operative site directly. To avoid perioperative complications from this limitation, the authors have evaluated the usefulness of computer-assisted navigation techniques in surgical treatment of blowout fracture. Methods: Total 37 patients (14 medial orbital wall fractures and 23 inferior orbital wall fractures) with facial deformities ha... περισσότερα »

Schwannoma With Cystic Changes in the Pterygomandibular Space

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Schwannoma With Cystic Changes in the Pterygomandibular Space: [image: image] Abstract: Schwannomas are tumors that arise from Schwann cells. Although schwannomas can occur almost anywhere in the body where nerve cells are present, they rarely occur in the head and neck region, including the oral and maxillofacial region. Cystic changes in schwannomas are extremely rare. This report is on a case of schwannoma with cystic changes that occurred in the pterygomandibular space. A 46-year-old woman presented with a complaint of limited mouth opening and pain on the left side of the mand... περισσότερα »

Brows Asymmetry Correction With the Direct Approach

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Brows Asymmetry Correction With the Direct Approach: Myth or Reality?: [image: image]Objectives: The current article is aimed to test the effectiveness of direct and indirect brow lifting to correct brows asymmetry. Methods: Fifty patients treated with direct brow lift between January of 2011 and January of 2013 were investigated. All patients were men and treated under local anesthesia. In all patients, the brow lifting was associated with an upper blepharoplasty. The amount of brow elevation produced was assessed by comparison of the preoperative and at 1-year postoperative ver... περισσότερα »

Pathologic Mandibular Fracture as First Sign of Multiple Myeloma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Pathologic Mandibular Fracture as First Sign of Multiple Myeloma: [image: image]Abstract: Multiple myeloma (MM) is a neoplasia characterized by the proliferation of plasmacytoid cells, which produce abnormal immunoglobulins. It frequently creates local and systemic complications such as pathologic fractures and renal disease. This article reports the case of a 70-year-old man presenting a pathologic fracture of the right mandibular angle secondary to a plasmocytoma. He had a history of a previous pathologic fracture of the left mandibular angle 13 years before that was treated elsew... περισσότερα »

Cephalometric Assessment of Upper Airway Effects on Craniofacial Morphology

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Cephalometric Assessment of Upper Airway Effects on Craniofacial Morphology: Abstract: To investigate craniofacial growth deformities in children with upper airway obstruction, this controlled study was performed. Cephalometry is used as a screening test for anatomic abnormalities in patients with obstructive sleep apnea syndrome. Therefore, the current work selected this method to investigate the effect of upper airway obstruction on craniofacial morphology. Patients with upper airway obstruction (104) were compared with 71 controls. Patients with upper airway compromise had mandib...περισσότερα »

Social and Support Services Offered by Cleft and Craniofacial Teams

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Social and Support Services Offered by Cleft and Craniofacial Teams: A National Survey and Institutional Experience: Background: A multidisciplinary approach to patients with craniofacial abnormalities is the standard of care by the American Cleft Palate-Craniofacial Association (ACPA). The standards of team care, however, do not require provision of social support services beyond access to a social worker. The purpose of this investigation is to study social support services provided by ACPA teams, funding sources for services, and family interest in services. Methods: A survey w... περισσότερα »

Mandibular Condyle Reimplantation and Free Bone Grafting: Considerations to Increase Its Efficacy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Mandibular Condyle Reimplantation and Free Bone Grafting: Considerations to Increase Its Efficacy: Background: Mandibulectomy and disarticulation, resection of the lesion, and subsequent reimplantation of the condyle is a method to manage benign mandibular intraosseous lesions, involving the ramus but not extending to the mandibular condyle. Objective: This article presents some considerations to increase the efficacy of this method. Method and Material: Archived files of the patients that this method had been used for mandibular reconstruction were reevaluated. Patients were recal...περισσότερα »